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Relevant bibliographies by topics / Oncogenetic

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Journal articles

Academic literature on the topic 'Oncogenetic'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Oncogenetic"

1

Li, Xiao-Chen, Chenglin Liu, Tao Huang, and Yang Zhong. "The Occurrence of Genetic Alterations during the Progression of Breast Carcinoma." BioMed Research International 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/5237827.

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The interrelationship among genetic variations between the developing process of carcinoma and the order of occurrence has not been completely understood. Interpreting the mechanisms of copy number variation (CNV) is absolutely necessary for understanding the etiology of genetic disorders. Oncogenetic tree is a special phylogenetic tree inferential pictorial representation of oncogenesis. In our present study, we constructed oncogenetic tree to imitate the occurrence of genetic and cytogenetic alterations in human breast cancer. The oncogenetic tree model was built on CNV of ErbB2, AKT2, KRAS, PIK3CA, PTEN, and CCND1 genes in 963 cases of tumors with sequencing and CNA data of human breast cancer from TCGA. Results from the oncogenetic tree model indicate that ErbB2 copy number variation is the frequent early event of human breast cancer. The oncogenetic tree model based on the phylogenetic tree is a type of mathematical model that may eventually provide a better way to understand the process of oncogenesis.

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2

Lapointe, Julie, Michel Dorval, Jocelyne Chiquette, et al. "A Collaborative Model to Implement Flexible, Accessible and Efficient Oncogenetic Services for Hereditary Breast and Ovarian Cancer: The C-MOnGene Study." Cancers 13, no. 11 (2021): 2729. http://dx.doi.org/10.3390/cancers13112729.

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Medical genetic services are facing an unprecedented demand for counseling and testing for hereditary breast and ovarian cancer (HBOC) in a context of limited resources. To help resolve this issue, a collaborative oncogenetic model was recently developed and implemented at the CHU de Québec-Université Laval; Quebec; Canada. Here, we present the protocol of the C-MOnGene (Collaborative Model in OncoGenetics) study, funded to examine the context in which the model was implemented and document the lessons that can be learned to optimize the delivery of oncogenetic services. Within three years of implementation, the model allowed researchers to double the annual number of patients seen in genetic counseling. The average number of days between genetic counseling and disclosure of test results significantly decreased. Group counseling sessions improved participants’ understanding of breast cancer risk and increased knowledge of breast cancer and genetics and a large majority of them reported to be overwhelmingly satisfied with the process. These quality and performance indicators suggest this oncogenetic model offers a flexible, patient-centered and efficient genetic counseling and testing for HBOC. By identifying the critical facilitating factors and barriers, our study will provide an evidence base for organizations interested in transitioning to an oncogenetic model integrated into oncology care; including teams that are not specialized but are trained in genetics.

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3

Chakraborty, Sayan, and Wanjin Hong. "Oncogenetic engagement with mechanosensing." Nature Materials 19, no. 7 (2020): 707–9. http://dx.doi.org/10.1038/s41563-020-0700-1.

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4

Henriksson, Karin, Håkan Olsson, and Ulf Kristoffersson. "The need for oncogenetic counselling Ten years’ experience of a regional oncogenetic clinic." Acta Oncologica 43, no. 7 (2004): 637–49. http://dx.doi.org/10.1080/02841860410018520.

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5

Verma, Ram S., and Nicholas G. Triantafillou. "Oncogenetic map of human genome." Cancer Genetics and Cytogenetics 100, no. 1 (1998): 88–90. http://dx.doi.org/10.1016/s0165-4608(97)82239-x.

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6

Longerich, Thomas, Michael Martin Mueller, Kai Breuhahn, Peter Schirmacher, Axel Benner, and Christiane Heiss. "Oncogenetic tree modeling of human hepatocarcinogenesis." International Journal of Cancer 130, no. 3 (2011): 575–83. http://dx.doi.org/10.1002/ijc.26063.

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7

Negura, Lucian, and Anca Negura. "Sanger sequencing of MMR genes in a one-plate system." Revista Romana de Medicina de Laborator 26, no. 2 (2018): 153–63. http://dx.doi.org/10.2478/rrlm-2018-0008.

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Abstract Both incidence and mortality of colorectal cancer (CRC) in Romania have shown a continuous increase during the last decades. Hereditary Non-Polyposic Colorectal Cancer (HNPCC), also known as Lynch syndrome, is mainly attributable to mismatch repair (MMR) genes MSH2, MSH6, and MLH1. Individuals carrying germ-line mutations of these genes present high lifetime risk of colorectal and other cancers, compared to non-carriers. Oncogenetics is developed worldwide nowadays, for identifying hereditary predisposition to cancer and offering appropriate clinical follow-up to patients and mutation carriers in Lynch families. Molecular oncogenetic diagnosis in Lynch syndrome is based on complete Sanger sequencing of entire MMR genes, which is time and resources consuming, therefore needing an appropriate and adapted optimization. Conventional sequencing requires a sufficient number of available samples to be processed simultaneously, which increases the waiting time for diagnostic results. Complete analysis for only one patient meets difficult technical problems due to the complex co-amplification of all gene regions of interest within the same conditions, therefore increasing the costs and reducing the cost-effectiveness of the test. Here we present an original and robust technical protocol for sequencing the entire MSH2, MSH6, and MLH1 coding sequence for one patient in a single PCR plate. Our optimized and verified system overcomes all technical problems and offers a quick, robust, and cost-effective possibility to personalize molecular oncogenetic diagnosis in Lynch syndrome.

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8

Wang, Yu, Chenzhou Zhang, Nini Wang, et al. "Genetic basis of ruminant headgear and rapid antler regeneration." Science 364, no. 6446 (2019): eaav6335. http://dx.doi.org/10.1126/science.aav6335.

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Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.

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9

Heydebreck, A. v., B. Gunawan, and L. Fuzesi. "Maximum likelihood estimation of oncogenetic tree models." Biostatistics 5, no. 4 (2004): 545–56. http://dx.doi.org/10.1093/biostatistics/kxh007.

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10

von Wachenfeldt, A., Y. Brandberg, H. Johansson, and T. Fornander. "Socioeconomic status of women attending an oncogenetic counseling clinic." Journal of Clinical Oncology 25, no. 18_suppl (2007): 1526. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.1526.

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1526 Background: In women with a family history (FH) of breast cancer the risk can be substantially increased and starts at an earlier age compared with the general population. Women with FH of breast cancer are not suggested oncogenetic counselling unless the subject is brought up in the contact with medical professionals. Consequently, a woman with FH for breast cancer has to have knowledge about the possibility of counselling to come into question for information, advice and special surveillance program. The aim of this study was to characterize women at an oncogenetic counselling clinic in terms of socioeconomic status (SES) and to compare these data with population based figures from the same catchment area. Methods: All healthy women who had, once or repeatedly, been visiting the oncogenetic clinic at the Department of Oncology, Karolinska University Hospital / Sodersjukhuset, between April, 1998 - June, 2004 were eligible for study. A total of 307 out of 378 consecutive women consented to participate (81%) in the survey by returning mailed questionnaires. SES data were compared with official data for all women aged 24 -75 year from the same catchment area (n= 277 783 women). Results: See table . Conclusions: Women visiting the oncogenetic counselling clinic were higher educated, more often married and had a better economic situation than comparable women from the same catchment area. These findings indicate that efforts should be elaborated to increase the knowledge about the possibility of genetic counselling among women with FH for breast cancers. [Table: see text] No significant financial relationships to disclose.

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