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Journal articles on the topic 'ONCOTHERAPEUTICS'

Author: Grafiati

Published: 11 September 2023

Last updated: 31 July 2025

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1

Raja, Junaid, and David C. Madoff. "Oncopharmacology in Interventional Radiology." Seminars in Interventional Radiology 39, no. 04 (2022): 411–15. http://dx.doi.org/10.1055/s-0042-1758076.

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AbstractThe broad scope of malignancies treated in interventional oncology is mirrored by the breadth of oncotherapeutics, drugs used to treat cancer. Many of these treatments are administered endovascularly, though a group of therapies can be delivered percutaneously. Perhaps the best taxonomy of oncotherapeutics is based on their biological inactivity or activity and the mechanism by which they interact with treated and targeted tissues. As the fields of interventional oncology and oncotherapeutics continue to grow and expand, this framework may provide a more organized approach in helping d

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2

Ladd, Joseph. "Advancements in oncotherapeutics drive positive outcomes in cancer." Pharmacy Today 23, no. 7 (2017): 24–25. http://dx.doi.org/10.1016/j.ptdy.2017.06.019.

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Dailey, Kaitlin M., JuliAnne E. Allgood, Paige R. Johnson, et al. "The next frontier of oncotherapy: accomplishing clinical translation of oncolytic bacteria through genetic engineering." Future Microbiology 16, no. 5 (2021): 341–68. http://dx.doi.org/10.2217/fmb-2020-0245.

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The development of a ‘smart’ drug capable of distinguishing tumor from host cells has been sought for centuries, but the microenvironment of solid tumors continues to confound therapeutics. Solid tumors present several challenges for current oncotherapeutics, including aberrant vascularization, hypoxia, necrosis, abnormally high pH and local immune suppression. While traditional chemotherapeutics are limited by such an environment, oncolytic microbes are drawn to it – having an innate ability to selectively infect, colonize and eradicate solid tumors. Development of an oncolytic species would

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Kansara, Samarth, Vijay Pandey, Peter E. Lobie, Gautam Sethi, Manoj Garg, and Amit Kumar Pandey. "Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer." Cells 9, no. 6 (2020): 1511. http://dx.doi.org/10.3390/cells9061511.

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Triple-negative breast cancer (TNBC) is one of the most lethal forms of breast cancer (BC), with a significant disease burden worldwide. Chemoresistance and lack of targeted therapeutics are major hindrances to effective treatments in the clinic and are crucial causes of a worse prognosis and high rate of relapse/recurrence in patients diagnosed with TNBC. In the last decade, long non-coding RNAs (lncRNAs) have been found to perform a pivotal role in most cellular functions. The aberrant functional expression of lncRNAs plays an ever-increasing role in the progression of diverse malignancies,

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Ramesh, Bandla, Krishna Madhava, Gowri Gogada Jaisatya, et al. "A propsective oncotherapeutics: Isolation, partial purification and assessment of anti-coagulant properties of Tridax procumbens from leaf extracts." Onkologia i Radioterapia 19, no. 1 (2025): 01–11. https://doi.org/10.5281/zenodo.15581591.

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Medicinal plants, mostly herbs have been widely used since ancient times for the treatment of various human diseases including cancers, with the advent of technology and extensive research relating use of herbal drugs in the health care sector has increased. The WHO reports, almost 80% of people serve through medicinal plants and their products. About 25% of active pharmaceutical drugs were derived from herbal plants. This study investigates the potential anticoagulant properties of Tridax procumbens, a medicinal plant. The study demonstrates the isolation procedure of partially purified leaf

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Raftopoulou, Christina, Fani-Marlen Roumelioti, Eleni Dragona, et al. "Karyotypic Flexibility of the Complex Cancer Genome and the Role of Polyploidization in Maintenance of Structural Integrity of Cancer Chromosomes." Cancers 12, no. 3 (2020): 591. http://dx.doi.org/10.3390/cancers12030591.

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Ongoing chromosomal instability in neoplasia (CIN) generates intratumor genomic heterogeneity and limits the efficiency of oncotherapeutics. Neoplastic human cells utilizing the alternative lengthening of telomeres (ALT)-pathway, display extensive structural and numerical CIN. To unravel patterns of genome evolution driven by oncogene-replication stress, telomere dysfunction, or genotoxic therapeutic interventions, we examined by comparative genomic hybridization five karyotypically-diverse outcomes of the ALT osteosarcoma cell line U2-OS. These results demonstrate a high tendency of the compl

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Adeniji, Emmanuel A., Fisayo A. Olotu, and Mahmoud E. S. Soliman. "Exploring the Lapse in Druggability: Sequence Analysis, Structural Dynamics and Binding Site Characterization of K-RasG12C Variant, a Feasible Oncotherapeutics Target." Anti-Cancer Agents in Medicinal Chemistry 18, no. 11 (2019): 1540–50. http://dx.doi.org/10.2174/1871520618666180718110231.

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Background: The difficulty in druggability of K-Ras variant has presented a challenge in the treatment of cancer diseases associated with its dysfunctionality. Despite the identification of different binding sites, limited information exists in the literature about their characteristics. Therefore, identification, crossvalidation and characterization of its druggable sites would aid the design of chemical compounds that will arrest its dysfunctionality related oncogenesis. Objective: This study entails the identification, cross-validation and characterization of K-Ras G12C variant’s binding si

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8

Lantier, Louis, Agathe Poupee-Beauge, Louis Lantier, et al. "846 Neospora caninum – an immunotherapeutic protozoan against solid cancers." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A899. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0846.

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BackgroundImmunotherapy induces, provides, and/or reactivates anti-tumor immune responses. Some microorganisms also can initiate response that lyzes infected tumor and/or stimulates systemic immunity. Attenuated viruses or bacteria are well studied as oncotherapeutics, but not protozoa except Toxoplasma gondii.1 We assessed the effect on tumors of other protozoa that were naturally non-pathogenic to humans. Thus, we discovered the ability to use Neospora caninum (Nc) in a manner and form that demonstrated a synergistic array of pertinent immunotherapeutic characteristics against solid cancers.

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AbdRabou, Mervat Ahmed, Ahmed B. M. Mehany, Islam M. Farrag, et al. "Therapeutic Effect of Murine Bone Marrow-Derived Mesenchymal Stromal/Stem Cells and Human Placental Extract on Testicular Toxicity Resulting from Doxorubicin in Rats." BioMed Research International 2021 (August 6, 2021): 1–13. http://dx.doi.org/10.1155/2021/9979670.

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Oncotherapeutics like doxorubicin can affect male gonads; as a result, it leads to infertility. This work was conducted to demonstrate the toxic effects of doxorubicin on testes of male albino rats. Fifty male albino rats aged 5-7 weeks were used in this study. The animals were randomly separated into 5 sets (each set containing ten rats). Group I received saline (i.p.) for 4 weeks. Group II was given doxorubicin (DOX), 5 mg/kg BW (i.p.) once/week for 4 weeks. Groups III and IV were treated in the same way as the DOX group, left for one week without medication, and then injected with mesenchym

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10

Chhajed, Santosh Subhash, Pramodkumar P. Gupta, Sanjay Kshirsagar, Sakshi Tomar, Debarshi Kar Mahapatra, and Raji Sundararajan. "N-(2-(1H-benzo[d]imidazol-2-yl)Phenyl)-2- (Substituted-styryl)Aniline as Anti-proliferative Agents: Rejuvenating the Importance of Low Molecular Weight Ligands in Oncotherapeutics." Indian Journal of Pharmaceutical Education and Research 54, no. 2 (2020): 432–39. http://dx.doi.org/10.5530/ijper.54.2.49.

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11

Dailey, Kaitlin M., Krysten Vance, Kyle McAndrews, et al. "Abstract PO-037: Development of an RGD CRISPR-modified Clostridium novyi NT spores as an intravenous oncotherapy." Cancer Research 81, no. 22_Supplement (2021): PO—037—PO—037. http://dx.doi.org/10.1158/1538-7445.panca21-po-037.

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Abstract The efficacy of current oncotherapeutics is largely limited by an inability to access avascular tissues, which is in part responsible for forty years of stagnant pancreatic cancer statistics where the median survival remains a mere six months. Oncolytic bacteria such as Clostridium novyi-NT overcome this challenge with its ultrasensitive, innate affinity for hypoxic/necrotic areas found at the center of solid tumors and their metastases. While preclinical and clinical data from intratumoral injections of C. novyi-NT are promising, many tumors are inaccessible to such injections. Precl

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Park, Robin, Fariha Eshrat, Mohammed Al-Jumayli, Azhar Saeed, and Anwaar Saeed. "Immuno-Oncotherapeutic Approaches in Advanced Hepatocellular Carcinoma." Vaccines 8, no. 3 (2020): 447. http://dx.doi.org/10.3390/vaccines8030447.

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Advanced hepatocellular carcinoma has limited treatment options, but there has been extensive growth recently with cabozantinib, regorafenib, lenvatinib, nivolumab, atezolizumab, and bevacizumab, which are some of the treatments that have received FDA approval just over the last three years. Because HCC tumor microenvironment is potentially immunogenic and typically characterized by inflammation, immunotherapy has been proposed as a potential novel therapeutic approach, which has prompted studies in advanced HCC patients investigating various immune-therapeutic strategies such as CAR-T cell th

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O’Reilly, Mary, Anna Linehan, Aleksandar Krstic, et al. "Oncotherapeutic Strategies in Early Onset Colorectal Cancer." Cancers 15, no. 2 (2023): 552. http://dx.doi.org/10.3390/cancers15020552.

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Early onset colorectal cancer (EOCRC), defined as colorectal cancers in patients aged less than 50 years, is becoming an increasingly common issue, globally. Since 1994, the incidence of this condition has been rising by 2% annually. Approximately one in five patients under 50 years of age diagnosed with colorectal cancer have an underlying genetic predisposition syndrome. The detection of cancer among the other 80% of patients poses a considerable task, as there is no family history to advocate for commencing early screening in this group. Patients with EOCRC have distinct social, spiritual,

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14

Singh, Prafull Kumar, Ashok K. Tiwari, R. S. Rajmani, et al. "Apoptin as a Potential Viral Gene Oncotherapeutic Agent." Applied Biochemistry and Biotechnology 176, no. 1 (2015): 196–212. http://dx.doi.org/10.1007/s12010-015-1567-5.

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15

Ye, Johan Z., Finn B. Hansen, Robert W. Mills, and Alicia Lundby. "Oncotherapeutic Protein Kinase Inhibitors Associated With Pro-Arrhythmic Liability." JACC: CardioOncology 3, no. 1 (2021): 88–97. http://dx.doi.org/10.1016/j.jaccao.2021.01.009.

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Tsymbal, Sergey, Ge Li, Nikol Agadzhanian, et al. "Recent Advances in Copper-Based Organic Complexes and Nanoparticles for Tumor Theranostics." Molecules 27, no. 20 (2022): 7066. http://dx.doi.org/10.3390/molecules27207066.

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Treatment of drug-resistant forms of cancer requires consideration of their hallmark features, such as abnormal cell death mechanisms or mutations in drug-responding molecular pathways. Malignant cells differ from their normal counterparts in numerous aspects, including copper metabolism. Intracellular copper levels are elevated in various cancer types, and this phenomenon could be employed for the development of novel oncotherapeutic approaches. Copper maintains the cell oxidation levels, regulates the protein activity and metabolism, and is involved in inflammation. Various copper-based comp

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17

Jain, Rifika, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, and Gnanasekar Munirathinam. "Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights." Pharmacological Research 178 (April 2022): 106138. http://dx.doi.org/10.1016/j.phrs.2022.106138.

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Kovács, Dávid, Nóra Igaz, Mohana K. Gopisetty, and Mónika Kiricsi. "Cancer Therapy by Silver Nanoparticles: Fiction or Reality?" International Journal of Molecular Sciences 23, no. 2 (2022): 839. http://dx.doi.org/10.3390/ijms23020839.

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As an emerging new class, metal nanoparticles and especially silver nanoparticles hold great potential in the field of cancer biology. Due to cancer-specific targeting, the consequently attenuated side-effects and the massive anti-cancer features render nanoparticle therapeutics desirable platforms for clinically relevant drug development. In this review, we highlight those characteristics of silver nanoparticle-based therapeutic concepts that are unique, exploitable, and achievable, as well as those that represent the critical hurdle in their advancement to clinical utilization. The collectio

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Alekseenko, I. V., M. B. Kostina, E. O. Serebrovskaia, V. K. Potapov, and E. D. Sverdlov. "Comparative analysis of gene therapy systems expressing two oncotherapeutic genes under control of single promotor." Molecular Genetics Microbiology and Virology (Russian version) 36, no. 1 (2018): 14. http://dx.doi.org/10.18821/0208-0613-2018-36-1-14-18.

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Alekseenko, I. V., M. B. Kostina, E. O. Serebrovskaya, V. K. Potapov, and E. D. Sverdlov. "Comparative Analysis of Gene Therapy Systems Expressing Two Oncotherapeutic Genes under Control of a Single Promotor." Molecular Genetics, Microbiology and Virology 33, no. 1 (2018): 15–20. http://dx.doi.org/10.3103/s0891416818010020.

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21

Tuli, Hardeep Singh, Vivek Kumar Garg, Jinit K. Mehta, et al. "Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects." OncoTargets and Therapy Volume 15 (November 2022): 1419–48. http://dx.doi.org/10.2147/ott.s366630.

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22

Amoah, Abdul-Saleem, Nikolay B. Pestov, Tatyana V. Korneenko, Igor A. Prokhorenko, Georgy F. Kurakin, and Nickolai A. Barlev. "Lipoxygenases at the Intersection of Infection and Carcinogenesis." International Journal of Molecular Sciences 25, no. 7 (2024): 3961. http://dx.doi.org/10.3390/ijms25073961.

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The persisting presence of opportunistic pathogens like Pseudomonas aeruginosa poses a significant threat to many immunocompromised cancer patients with pulmonary infections. This review highlights the complexity of interactions in the host’s defensive eicosanoid signaling network and its hijacking by pathogenic bacteria to their own advantage. Human lipoxygenases (ALOXs) and their mouse counterparts are integral elements of the innate immune system, mostly operating in the pro-inflammatory mode. Taking into account the indispensable role of inflammation in carcinogenesis, lipoxygenases have c

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Tuli, Hardeep Singh, Vivek Kumar Garg, Jinit K. Mehta, et al. "Licorice (Glycyrrhiza Glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects [Corrigendum]." OncoTargets and Therapy Volume 17 (January 2024): 1–2. http://dx.doi.org/10.2147/ott.s459103.

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24

Pierce, Kyle M., William R. Miklavcic, Kyle P. Cook, et al. "The Evolution and Future of Targeted Cancer Therapy: From Nanoparticles, Oncolytic Viruses, and Oncolytic Bacteria to the Treatment of Solid Tumors." Nanomaterials 11, no. 11 (2021): 3018. http://dx.doi.org/10.3390/nano11113018.

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While many classes of chemotherapeutic agents exist to treat solid tumors, few can generate a lasting response without substantial off-target toxicity despite significant scientific advancements and investments. In this review, the paths of development for nanoparticles, oncolytic viruses, and oncolytic bacteria over the last 20 years of research towards clinical translation and acceptance as novel cancer therapeutics are compared. Novel nanoparticle, oncolytic virus, and oncolytic bacteria therapies all start with a common goal of accomplishing therapeutic drug activity or delivery to a speci

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Ortiz-Hernandez, Greisha L., Evelyn S. Sanchez-Hernandez, Pedro T. Ochoa, and Carlos A. Casiano. "The Emerging Roles of the Stress Epigenetic Reader LEDGF/p75 in Cancer Biology and Therapy Resistance: Mechanisms and Targeting Opportunities." Cancers 16, no. 23 (2024): 3957. http://dx.doi.org/10.3390/cancers16233957.

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The lens epithelium derived growth factor of 75 kD (LEDGF/p75) is a transcription co-activator and epigenetic reader that has emerged as a stress oncoprotein in multiple human cancers. Growing evidence indicates that it promotes tumor cell survival against certain therapeutic drugs. The amino (N)-terminal region of LEDGF/p75 contains a PWWP domain that reads methylated histone marks, critical for recognizing transcriptionally active chromatin sites. Its carboxyl (C)-terminus has an integrase binding domain (IBD) that serves as the binding site for the HIV-1 integrase and multiple oncogenic tra

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Pan, Lina, Xiyu Liu, Dianfa Fan, et al. "Study of Oncolytic Virus Preservation and Formulation." Pharmaceuticals 16, no. 6 (2023): 843. http://dx.doi.org/10.3390/ph16060843.

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In recent years, oncolytic viruses (OVs) have emerged as an effective means of treating cancer. OVs have multiple oncotherapeutic functions including specifically infecting and lysing tumor cells, initiating immune cell death, attacking and destroying tumor angiogenesis and triggering a broad bystander effect. Oncolytic viruses have been used in clinical trials and clinical treatment as drugs for cancer therapy, and as a result, oncolytic viruses are required to have long-term storage stability for clinical use. In the clinical application of oncolytic viruses, formulation design plays a decis

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Almeida, Teresa, Maria Elisa Soares, José Cavalheiro, and Maria de Lourdes Bastos. "Silicon and iron levels in tissues of animals treated with a “ferrimagnetic ceramic” with oncotherapeutic potential (anti-tumor) value." Journal of Trace Elements in Medicine and Biology 16, no. 4 (2002): 255–59. http://dx.doi.org/10.1016/s0946-672x(02)80054-2.

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Szivos, László, József Virga, Zoltán Mészár, et al. "Prognostic Role of Invasion-Related Extracellular Matrix Molecules in Diffusely Infiltrating Grade 2 and 3 Astrocytomas." Brain Sciences 14, no. 11 (2024): 1157. http://dx.doi.org/10.3390/brainsci14111157.

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Background: Astrocytoma, an IDH-mutant is a common primary brain tumor. Total surgical resection is not feasible due to peritumoral infiltration mediated by extracellular matrix (ECM) molecules. Methods: This study aimed at determining the expression pattern of ECM molecules in different prognostic groups of WHO grade 2 and grade 3 patients and identifying the effect of onco-radiotherapy on tumor cell invasion of grade 3 patients. Gene and protein expression of ECM molecules was determined by qRT-PCR and immunohistochemistry, respectively. Results: In the different prognostic groups of grade 2

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Tiwari, Shreya, Rakesh Mehta, Ayush Kushwaha, and Rajnandani Katariya. "A PRELIMINARY SCREENING OF BACTERIAL ISOLATES PRODUCING AN ONCOTHERAPEUTIC ENZYME ASPARAGINASE FROM SOME SEWAGE WATER SAMPLES OF BHOPAL, M.P. INDIA." Asian Journal of Pharmaceutical Education and Research 10, no. 2 (2021): 19–26. http://dx.doi.org/10.38164/ajper/10.2.2021.19-26.

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Nazarenko, Alina S., Yulia K. Biryukova, Kirill N. Trachuk, et al. "Immunotherapeutic Potential of the Yellow Fever Virus Vaccine Strain 17D for Intratumoral Therapy in a Murine Model of Pancreatic Cancer." Vaccines 13, no. 1 (2025): 40. https://doi.org/10.3390/vaccines13010040.

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Objective: We evaluate the immunotherapeutic potential of the yellow fever virus vaccine strain 17D (YFV 17D) for intratumoral therapy of pancreatic cancer in mice. Methods: The cytopathic effect of YFV 17D on mouse syngeneic pancreatic cancers cells were studied both in vitro and in vivo and on human pancreatic cancers cells in vitro. Results: YFV 17D demonstrated a strong cytopathic effect against human cancer cells in vitro. Although YFV 17D did not exhibit a lytic effect against Pan02 mouse cells in vitro, a single intratumoral administration of 17D caused a delay in tumor growth and an in

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Shen, Yaoyao, Fan Sun, Liu Zhang, et al. "Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase." Journal of Biological Chemistry 295, no. 16 (2020): 5509–18. http://dx.doi.org/10.1074/jbc.ra119.010922.

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Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemoth

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Trujillo-Nolasco, Maydelid, Pedro Cruz-Nova, Guillermina Ferro-Flores, et al. "Development of 177Lu-DN(C19)-CXCR4 Ligand Nanosystem for Combinatorial Therapy in Pancreatic Cancer." Journal of Biomedical Nanotechnology 17, no. 2 (2021): 263–78. http://dx.doi.org/10.1166/jbn.2021.3016.

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Pancreatic cancer is highly lethal and has a poor prognosis. The most common alteration during the formation of pancreatic tumors is the activation of KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) oncogene. As a new therapeutic strategy, the C19 molecule ((2S)-N-(2,5-dichlorophenyl)-2-[(3,4-dimethoxyphenyl)-methylamine]propanamide) blocks the KRAS-membrane association in cancer cells. In addition, the chemokine receptor CXCR4 is overexpressed in pancreatic cancer. In this research, a new dendrimer-based nanoradiopharmaceutical (177Lu-DN(C19)-CXCR4L) encapsulating C19 and functionalized t

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Vay, Christian, Shahrooz Babaei, Sami-Alexander Safi, et al. "Clinicopathological and Prognostic Value of Survivin Expression in Surgically Resected Pancreatic Ductal Adenocarcinoma." Cancers 14, no. 14 (2022): 3494. http://dx.doi.org/10.3390/cancers14143494.

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Background: Survival after surgery for pancreatic ductal adenocarcinoma (PDAC) remains poor. Thus, novel therapeutic concepts focus on the development of targeted therapies. In this context, inhibitor of apoptosis protein (IAP) survivin is regarded as a promising oncotherapeutic target. However, its expression and prognostic value in different tumour compartments of PDAC have not been studied. Methods: Immunohistochemical analysis of survivin in different PDAC tumour compartments from 236 consecutive patients was correlated with clinicopathological variables and survival. Results: In compariso

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Al-Serwi, Rasha H., Mohamed A. Eladl, Mohamed El-Sherbiny, et al. "Targeted Drug Administration onto Cancer Cells Using Hyaluronic Acid–Quercetin-Conjugated Silver Nanoparticles." Molecules 28, no. 10 (2023): 4146. http://dx.doi.org/10.3390/molecules28104146.

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Quercetin (QtN) displays low systemic bioavailability caused by poor water solubility and instability. Consequently, it exerts limited anticancer action in vivo. One solution to increase the anticancer efficacy of QtN is the use of appropriate functionalized nanocarriers that preferentially target and deliver the drug to the tumor location. Herein, a direct advanced method was designed to develop water-soluble hyaluronic acid (HA)-QtN-conjugated silver nanoparticles (AgNPs). HA-QtN reduced silver nitrate (AgNO3) while acting as a stabilizing agent to produce AgNPs. Further, HA-QtN#AgNPs served

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Bano, Samar, Lubna Rasool, Abdur Rauf, and Shabbir Hussain. "In silico Characterization of Heat Shock Protein HSP27 in Mammals." World Journal of Biology and Biotechnology 8, no. 3 (2023): 1. http://dx.doi.org/10.33865/wjb.008.03.0933.

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Dairy animals have a significant role in every country’s agricultural economy. Livestock is the major sub-sector of the agricultural industry and the value of dairy products is increasing globally. Under pathological circumstances heat shock proteins (HSPs) promote protein repair, folding, refolding of misfolded peptides, and possible breakdown of irreparable proteins. Heat shock protein 27 (HSP27) is a member of the small heat shock protein family (sHSPs) also called HSPB1. HSP27 is crucial in the regulation and progression of different types of tumors and also acts as an oncotherapeutic targ

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Cai, Ruimin, Guangyuan Meng, Yi Li, et al. "The oncolytic efficacy and safety of avian reovirus and its dynamic distribution in infected mice." Experimental Biology and Medicine 244, no. 12 (2019): 983–91. http://dx.doi.org/10.1177/1535370219861928.

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Primary liver cancer is a major public health challenge that ranks as the third most common cause of cancer worldwide despite therapeutic improvement. Reovirus has been emerging as a potential anti-cancer agent and is undergoing multiple clinical trials, and it is reported that reovirus can preferentially cause the cell death of a variety of cancers in a manner of apoptosis. As few studies have reported the efficacy of oncolytic activity and safety profile of avian reovirus, in our study, LDH assay, MTT assay, DAPI staining, and flow cytometry assay were performed to demonstrate the oncolytic

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Rostovsky, Irina, and Claytus Davis. "Induction of an Embryonic Mouse Innate Immune Response following Inoculation In Utero with Minute Virus of Mice." Journal of Virology 89, no. 4 (2014): 2182–91. http://dx.doi.org/10.1128/jvi.02908-14.

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ABSTRACTWe used an embryonic-infection model system to show that MVMp, the prototypic minute virus of mice (MVM) serotype and a member of the genusProtoparvovirus, triggers a comprehensive innate immune response in the developing mouse embryo. Direct inoculation of the midtrimester embryoin uterowith MVMp results in a widespread, productive infection. During a 96-h infection course, embryonic beta interferon (IFN-β) and IFN-γ transcription were induced 90- and 60-fold, respectively. IFN-β levels correlated with the embryo viral burden, while IFN-γ levels first increased and then decreased. Pro

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Krishnamurthyreddy, B., M. S. Vidyasagar, R. Koteshwar, et al. "A phase IIb 4-arm open-label randomized study to assess the safety and efficacy of h-R3 monoclonal antibody against EGFR in combination with chemoradiation therapy or radiation therapy in patients with advanced (stage III or IVA) inoperable head and neck cancer." Journal of Clinical Oncology 27, no. 15_suppl (2009): 6041. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6041.

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6041 Background: Patients (pt) with advanced inoperable squamous cell carcinoma of the head and neck (SCCHN) have poor radiotherapy alone (RT) outcome. EGFR is over-expressed in >90% SCCHN. h-R3mAb (BIOMAb/nimotuzumab/TheraCIM) is a humanized monoclonal antibody, a validated oncotherapeutic-targeting EGFR. Objective: To investigate the safety and efficacy of concurrent h-R3mAb in combination with chemoradiotherapy of SCCHN. Methods: September 2004–2005, pt 18–70 yrs, SCCHN stageIII-IVA, 113 screened, 92 enrolled and randomly asssigned to, Group A: radical radiotherapy (pt) and Group B: chem

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Raghavan, Kristopher S., Jonathan T. Sullivan, Carmen Navia, Rachel H. Fong, and Benjamin J. Doranz. "Abstract 5798: Preclinical safety assessment for specificity of biotherapeutics using the membrane proteome array." Cancer Research 84, no. 6_Supplement (2024): 5798. http://dx.doi.org/10.1158/1538-7445.am2024-5798.

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Abstract Rigorous specificity analysis is critical for the development of antibody-based therapies, as even minimal off-target binding can lead to toxicity and clinical failures. Long believed to be exquisitely specific, recent preclinical data and our own work indicate that monoclonal antibodies (MAbs) frequently (~25%) display cross-reactivity. In many cases, off-target interactions occur with unrelated proteins that cannot be predicted by protein sequence homology. Cross-reactivity can lead to serious or even life-threatening consequences especially when MAbs are configured as bispecifics,

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Wrangle, John M., Mark P. Rubinstein, Caroline Mart, et al. "Phase I trial characterizing the pharmacokinetic profile and NK and CD8+ t cell expansion with n-803, a chimeric IL-15 superagonist, in healthy volunteers." Journal of Clinical Oncology 38, no. 15_suppl (2020): e15008-e15008. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15008.

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e15008 Background: The oncotherapeutic promise of IL-15, a potent immune stimulant, is limited by short serum half-life. The fusion protein N-803 is an IL-15 superagonist complex that has > 20-fold longer half-life in vivo vs IL-15. This study characterized the pharmacokinetic (PK) profile, biological activity, and safety of N-803 after subcutaneous administration to healthy human volunteers. Methods: Volunteers were randomized 1:1 to receive 1 mg/mL or 2 mg/mL N-803. Each subject received 2 doses of N-803: 10 µg/kg followed 24 days later by 20 µg/kg. After each dose, PK and safety measures

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Sainathan, Satheesh K., Justin H. Lipner, Jennifer I. Drake, Brogan A. Epkins, Brianna M. Roux, and Alastair J. King. "Abstract 1877: Measurement of cytosolic DNA sensing cGAS-STING pathway functional activity using in vitro phenotypic assay models." Cancer Research 82, no. 12_Supplement (2022): 1877. http://dx.doi.org/10.1158/1538-7445.am2022-1877.

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Abstract Innate immunity plays a vital role in detecting cytoplasmic nucleic acids resulting from viral infection or the presence of tumor cells. Cytosolic DNA is sensed by the cyclic-GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, and in the case of tumors, activation of this pathway has potential to both positively and negatively modulate cancer development. Activation of the STING pathway is a key prerequisite for type I IFN production that is needed for either endogenous or treatment-induced cancer immune responses, and reduced cGAS-STING expression is associated with

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Kívés, Zsuzsanna, Dóra Endrei, Diána Elmer, et al. "A vastag- és végbéldaganat okozta országos epidemiológiai és egészségbiztosítási betegségteher Magyarországon." Orvosi Hetilap 162, Supplement-1 (2021): 14–21. http://dx.doi.org/10.1556/650.2021.32152.

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Összefoglaló. Bevezetés: Magyarországon a vastag- és a végbéldaganat mindkét nem esetében a harmadik leggyakoribb daganatos megbetegedés és a második leggyakoribb halálok. Célkitűzés: Elemzésünk célja volt a vastag- és végbéldaganat okozta éves epidemiológiai és egészségbiztosítási betegségteher meghatározása Magyarországon. Adatok és módszerek: Az adatok a Nemzeti Egészségbiztosítási Alapkezelő (NEAK) finanszírozási adatbázisából származnak, és a 2018. évet fedik le. A daganat típusait a Betegségek Nemzetközi Osztályozása (BNO, 10. revízió) szerinti C18-as, C19-es, C20-as, C21-es, D010–D014-e

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Ghosh, Dr Sayantan, and Ms Manaswi N. "Oncotherapeutics: A General Overview." Journal of Current Medical Research and Opinion 4, no. 04 (2021). http://dx.doi.org/10.15520/jcmro.v4i04.418.

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Experimental oncotherapeutics programs have been in place at major academic centres for over four decades. The emergence of molecular targeting agents and the recent introduction of immuno-oncology drugs have expanded the scope and eligibility for first-in-human trials. Improved understanding of tumor biology coupled with the ability to screen for tumor associated targets, as well as, genetic alterations have heralded the era of personalized (personalized or precision) cancer treatment. Molecular targeting agents with their improved tolerability and sustained responses compared to conventional

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Mandal, Saurabh, Naisarg Gamit, Subhankar Biswas, C. Mallikarjun Rao, Gautam Sethi, and Sudha Warrier. "An efficient human stem cells derived cardiotoxicity testing platform for testing oncotherapeutic analogues of quercetin and cinnamic acid." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-21721-3.

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AbstractOncotherapeutics research is progressing at a rapid pace, however, not many drugs complete the successful clinical trial because of severe off-target toxicity to cardiomyocytes which ultimately leads to cardiac dysfunction. It is thus important to emphasize the need for early testing for possible cardiotoxicity of emerging oncotherapeutics. In this study, we assessed a novel stem cell-derived cardiac model for testing for cardiotoxicity of novel oncotherapeutics. We evaluated the cardiotoxic effect of synthesized derivatives of oncotherapeutics, quercetin (QMJ-2, -5, and -6) and cinnam

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Kumar, Lalit. "Exploring therapeutic potential of plga nanoparticles in oncotherapeutics." Micro and Nanosystems 14 (May 4, 2022). http://dx.doi.org/10.2174/1876402914666220504143153.

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Oleas, Diana, Anna Saurina Solé, Mónica Pou Potau, et al. "#2910 Renal toxicities in oncology at a secondary level hospital within the first 6 months of outpatient consultation establishment." Nephrology Dialysis Transplantation 39, Supplement_1 (2024). http://dx.doi.org/10.1093/ndt/gfae069.400.

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Abstract Background and Aims In recent years the discovery of targeted therapies in oncology have been a revolution with spectacular results for patients with advanced neoplasia and metastasis. Representing a more precise approach to interfering with tumorigenesis, these therapies exhibit superior tolerability profile in terms of toxicity and have significantly improved overall survival (1). Numerous studies have demonstrated the increased risk of cancer patients developing acute renal failure and progressing to chronic kidney disease, both contributing to higher mortality. The use of these no

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Cheke, Rameshwar S., and Prashant S. Kharkar. "Covalent inhibitors: An ambitious approach for the discovery of newer oncotherapeutics." Drug Development Research, December 6, 2023. http://dx.doi.org/10.1002/ddr.22132.

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AbstractCovalent inhibitors have been used to treat several diseases for over a century. However, strategic approaches for the rational design of covalent drugs have taken a definitive shape in recent times. Since the first appearance of covalent inhibitors in the late 18th century, the field has grown tremendously and around 30% of marketed drugs are covalent inhibitors especially, for oncology indications. However, the off‐target toxicity and safety concerns can be significant issues related to the covalent drugs. Covalent kinase inhibitor (CKI) targeted oncotherapeutics has advanced dramati

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Dailey, Kaitlin M., Reed I. Jacobson, Paige R. Johnson, et al. "Methods and Techniques to Facilitate the Development of Clostridium novyi NT as an Effective, Therapeutic Oncolytic Bacteria." Frontiers in Microbiology 12 (March 29, 2021). http://dx.doi.org/10.3389/fmicb.2021.624618.

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The tumor microenvironment is characterized by anomalous vascularization, hypoxia, and acidity at the core of solid tumors that culminates in concentrated necrosis and immune system dysregulation among other effects. While this environment presents several challenges for the development of oncotherapeutics that deliver their activity via the enhanced permeability and retention (EPR) effect of the leaky blood vessels around a tumor, oncolytic bacteria, or a class of bacteria with a noted capacity to lyse solid tumors, are attracted to the very environment found at the center of solid tumors tha

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Traba, Javier, Michael N. Sack, Thomas A. Waldmann, and Olga M. Anton. "Immunometabolism at the Nexus of Cancer Therapeutic Efficacy and Resistance." Frontiers in Immunology 12 (May 17, 2021). http://dx.doi.org/10.3389/fimmu.2021.657293.

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Constitutive activity of the immune surveillance system detects and kills cancerous cells, although many cancers have developed strategies to avoid detection and to resist their destruction. Cancer immunotherapy entails the manipulation of components of the endogenous immune system as targeted approaches to control and destroy cancer cells. Since one of the major limitations for the antitumor activity of immune cells is the immunosuppressive tumor microenvironment (TME), boosting the immune system to overcome the inhibition provided by the TME is a critical component of oncotherapeutics. In th

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Sackstein, Robert, and Patricio Duarte. "Latin America and Evolving Oncotherapeutics using CAR-T Cells, Conjugated Antibodies, and Bi-specific Antibodies." Blood Global Hematology, April 2025, 100007. https://doi.org/10.1016/j.bglo.2025.100007.

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