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Journal articles on the topic "One-on-one aide"
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Quinn, M. M., P. K. Markkanen, C. J. Galligan, S. R. Sama, J. E. Lindberg, and M. F. Edwards. "Healthy Aging Requires a Healthy Home Care Workforce: the Occupational Safety and Health of Home Care Aides." Current Environmental Health Reports 8, no. 3 (May 12, 2021): 235–44. http://dx.doi.org/10.1007/s40572-021-00315-7.
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Abstract Purpose of Review To identify important home care (HC) aide occupational safety and health (OSH) hazards and examine how addressing these can improve aide health and the delivery of HC services overall. Specifically, this review seeks to answer: Why is HC aide OSH important? What are the most significant OSH challenges? How can improving HC aide OSH also improve the safety and health of their clients? What implications do the findings have for future research? Recent Findings HC is one of the fastest growing US industries. Aides comprise its largest workforce and are increasingly needed to care for the rapidly aging population. There is an aide shortage due in part to instabilities in HC work organization and to serious job-specific hazards, resulting in aides losing work time. Recent social, economic, and technological factors are rapidly changing the nature of HC work, creating OSH hazards similar to those found in nursing homes. At the same time, aides are experiencing social and economic inequities that increase their vulnerability to OSH hazards. These hazards are also a burden on employers who are challenged to recruit, retain, and train aides. OSH injuries and illness interrupt the continuity of care delivery to clients. Many OSH hazards also put HC clients and families at risk. Summary A new framework and methodologies are needed to assess aide and client safety together in order to guide future HC research, policies, and practices. Government, industry, and labor commitment is needed to fund and coordinate a comprehensive, multidisciplinary research program.
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Marshall, Kerry. "Multiskilling — Re-Engineering Work Process." Healthcare Management Forum 8, no. 2 (July 1995): 32–36. http://dx.doi.org/10.1016/s0840-4704(10)60907-6.
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Many North American companies have recognized the need to re-engineer their core processes to achieve breakthrough improvements in cost, service and efficiency. In fact, it is estimated that U.S. companies alone will spend millions on business re-engineering projects this year. But change experts say that most re-engineering is in name only, cautiously tackling only one process or department at a time. Even fewer hospitals have attempted this magnitude of change. Toronto's Sunnybrook Health Science Centre is the first institution of its size in Canada to embark on a multifaceted re-engineering strategy toward a model of patient focused care. The following is an overview of Sunnybrook's experience with the first of these strategies: multiskilling service workers. The concept of multiskilling provides for a focus on redesigning job classifications to broaden the scope of responsibility. For Sunnybrook, this entailed the amalgamation of six service positions — unit aide, health care aide, dietary aide, orderly, porter, housekeeper and attendant into one service assistant position.
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BROWN, LAUREN. "Hurricane—No Power—No Water—A Tree on the Roof! A Day in the Life of One Creative Hospice Aide." Home Healthcare Nurse 30, no. 7 (2012): E1—E2. http://dx.doi.org/10.1097/nhh.0b013e31825b11d5.
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Karlsson, Nicole D., Pia K. Markkanen, David Kriebel, Rebecca J. Gore, Catherine J. Galligan, Susan R. Sama, and Margaret M. Quinn. "Home care aides’ experiences of verbal abuse: a survey of characteristics and risk factors." Occupational and Environmental Medicine 76, no. 7 (June 11, 2019): 448–54. http://dx.doi.org/10.1136/oemed-2018-105604.
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ObjectiveViolence from care recipients and family members, including both verbal and physical abuse, is a serious occupational hazard for healthcare and social assistance workers. Most workplace violence studies in this sector focus on hospitals and other institutional settings. This study examined verbal abuse in a large home care (HC) aide population and evaluated risk factors.MethodsWe used questionnaire survey data collected as part of a larger mixed methods study of a range of working conditions among HC aides. This paper focuses on survey responses of HC aides (n=954) who reported on verbal abuse from non-family clients and their family members. Risk factors were identified in univariate and multivariable analyses.ResultsTwenty-two per cent (n=206) of aides reported at least one incident of verbal abuse in the 12 months before the survey. Three factors were found to be important in multivariable models: clients with dementia (relative risk (RR) 1.38, 95% CI 1.07 to 1.78), homes with too little space for the aide to work (RR 1.52, 95% CI 1.17 to 1.97) and predictable work hours (RR 0.74, 95% CI 0.58 to 0.94); two additional factors were associated with verbal abuse, although not as strongly: having clients with limited mobility (RR 1.35, 95% CI 0.94 to 1.93) and an unclear plan for care delivery (RR 1.27, 95% CI 0.95 to 1.69). Aides reporting verbal abuse were 11 times as likely to also report physical abuse (RR 11.53; 95% CI 6.84 to 19.45).ConclusionsVerbal abuse is common among HC aides. These findings suggest specific changes in work organisation and training that may help reduce verbal abuse.
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Campbell, Brian, James Yaggie, and Daniel Cipriani. "Temporal Influences of Functional Knee Bracing on Torque Production of the Lower Extremity." Journal of Sport Rehabilitation 15, no. 3 (August 2006): 215–27. http://dx.doi.org/10.1123/jsr.15.3.215.
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Context:Functional knee braces (FKB) are used prophylactically and in rehabilitation to aide in the functional stability of the knee.Objective:To determine if alterations in select lower extremity moments persist throughout a one hour period in healthy individuals.Design:2X5 repeated measures design.Setting:Biomechanics Laboratory.Subjects:Twenty subjects (14 male and 6 female, mean age 26.5±7 yrs; height 172.4±13 cm; weight 78.6±9 kg), separated into braced (B) and no brace (NB) groups.Intervention:A one-hour exercise program divided into three 20 minute increments.Main Outcome Measures:Synchronized three-dimensional kinematic and kinetic data were collected at 20-minute increments to assess the effect of the FKB on select lower extremity moments and vertical ground reaction forces.Results:Increase in hip moment and a decrease in knee moment were noted immediately after brace application and appeared to persist throughout a one hour bout of exercise.Conclusions:The FKB and the exercise intervention caused decreases in knee joint moments and increases in hip joint moments.
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Compton, Rebekah M., Kimberly S. Bednar, Peggie E. Donowitz, and M. Norman Oliver. "Management of patients with type 2 diabetes mellitus in the Grand-Aides Program." Journal of Nursing Education and Practice 10, no. 3 (November 18, 2019): 1. http://dx.doi.org/10.5430/jnep.v10n3p1.
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Objective: To evaluate the Grand-Aides Program for patients with type 2 diabetes mellitus (T2DM) according to the variables of body weight, blood pressure, medication adherence, and hospital consultation and readmissions.Methods: Patients ages 18 years or older with a past medical history of T2DM, hypertension (HTN), and/or obesity and who were recently seen in the emergency department (ED) or recently admitted to the hospital were eligible to enroll in the Grand-Aides Program. Eligible patients were identified after hospital or ED discharge and were asked to enroll in the in-home based program from March 2016 through June 2018. In-home visit protocol was defined prior to patient enrollment with intense in-home visits during the first weeks of enrollment followed by monthly visits for the duration of enrollment in the program. In-home visit frequency was adjusted on as needed basis so that patients at higher risk for ED visits or hospitalization were seen more frequently. In-home visits were performed by trained Grand-Aide who for the purpose of this study was a certified nursing assistant (CNA). The Grand-Aide underwent eighty hours of didactic training which included visit protocols, visit schedules, and data collection. The one-on-one in-home patient with every visit were supervised by a registered nurse (RN) or nurse practitioner (NP) via video or telephone contact near the conclusion of the visit. Active patients at the University of Virginia Family Medicine clinic were eligible for enrollment. Fifty-seven patients with T2DM worked with Grand-Aides for three months and an additional forty-eight T2DM patients worked with Grand-Aides for twelve months. Emergency department visits, all 30-day hospital readmissions, as well as blood pressure readings, medication adherence, weights, and glycated hemoglobin (HbA1c) were compared with the prior twelve months.Results: Systolic (p < .001) and diastolic (p < .01) blood pressures decreased (p < .01) at 1 year. At baseline 56 percent of the patients had a systolic blood pressure of >130 mmHg despite treatment; after 12 months, 48 percent of these were < 130. In those whose baseline diastolic blood pressure was > 90 mmHg, 100 percent had diastolic blood pressure < 90 mmHg at 1 year. Medication adherence by ARMS test at 1 year was 94 percent. Despite trending downward, weight and HbA1c did not change significantly. In the preceding, 58 percent had at least one ED visit, which was reduced by 50 percent (p < .01) with Grand-Aides; 30-day all-cause readmissions reduced by 50 percent to 6.3 percent. Conclusions: The Grand-Aides program was associated with a significant change in blood pressure control, high medication adherence and reductions in ED visits and readmissions that compare favorably with published comparative data. For systems “at risk” for preventable increased health care expense burden, the Grand-Aides program can result in significant savings.
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Scheurer, Simon, Janina Koch, Martin Kucera, Hȧkon Bryn, Marcel Bärtschi, Tobias Meerstetter, Tobias Nef, and Prabitha Urwyler. "Optimization and Technical Validation of the AIDE-MOI Fall Detection Algorithm in a Real-Life Setting with Older Adults." Sensors 19, no. 6 (March 18, 2019): 1357. http://dx.doi.org/10.3390/s19061357.
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Falls are the primary contributors of accidents in elderly people. An important factor of fall severity is the amount of time that people lie on the ground. To minimize consequences through a short reaction time, the motion sensor “AIDE-MOI” was developed. “AIDE-MOI” senses acceleration data and analyzes if an event is a fall. The threshold-based fall detection algorithm was developed using motion data of young subjects collected in a lab setup. The aim of this study was to improve and validate the existing fall detection algorithm. In the two-phase study, twenty subjects (age 86.25 ± 6.66 years) with a high risk of fall (Morse > 65 points) were recruited to record motion data in real-time using the AIDE-MOI sensor. The data collected in the first phase (59 days) was used to optimize the existing algorithm. The optimized second-generation algorithm was evaluated in a second phase (66 days). The data collected in the two phases, which recorded 31 real falls, was split-up into one-minute chunks for labelling as “fall” or “non-fall”. The sensitivity and specificity of the threshold-based algorithm improved significantly from 27.3% to 80.0% and 99.9957% (0.43) to 99.9978% (0.17 false alarms per week and subject), respectively.
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Cuttance, Glen, Kathryn Dansie, and Tim Rayner. "Paramedic Application of a Triage Sieve: A Paper-Based Exercise." Prehospital and Disaster Medicine 32, no. 1 (December 14, 2016): 3–13. http://dx.doi.org/10.1017/s1049023x16001163.
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AbstractIntroductionTriage is the systematic prioritization of casualties when there is an imbalance between the needs of these casualties and resource availability. The triage sieve is a recognized process for prioritizing casualties for treatment during mass-casualty incidents (MCIs). While the application of a triage sieve generally is well-accepted, the measurement of its accuracy has been somewhat limited. Obtaining reliable measures for triage sieve accuracy rates is viewed as a necessity for future development in this area.ObjectiveThe goal of this study was to investigate how theoretical knowledge acquisition and the practical application of an aide-memoir impacted triage sieve accuracy rates.MethodTwo hundred and ninety-two paramedics were allocated randomly to one of four separate sub-groups, a non-intervention control group, and three intervention groups, which involved them receiving either an educational review session and/or an aide-memoir. Participants were asked to triage sieve 20 casualties using a previously trialed questionnaire.ResultsThe study showed the non-intervention control group had a correct accuracy rate of 47%, a similar proportion of casualties found to be under-triaged (37%), but a significantly lower number of casualties were over-triaged (16%). The provision of either an educational review or aide-memoir significantly increased the correct triage sieve accuracy rate to 77% and 90%, respectively. Participants who received both the educational review and aide-memoir had an overall accuracy rate of 89%. Over-triaged rates were found not to differ significantly across any of the study groups.ConclusionThis study supports the use of an aide-memoir for maximizing MCI triage accuracy rates. A “just-in-time” educational refresher provided comparable benefits, however its practical application to the MCI setting has significant operational limitations. In addition, this study provides some guidance on triage sieve accuracy rate measures that can be applied to define acceptable performance of a triage sieve during a MCI.CuttanceG, DansieK, RaynerT. Paramedic application of a triage sieve: a paper-based exercise. Prehosp Disaster Med. 2017;32(1):3–13.
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O’Carroll, T., K. Glynn, D. Lyons, and K. Looney. "Aide memoire: What should a memory clinic or a memory assessment service look like?" Irish Journal of Psychological Medicine 34, no. 2 (November 24, 2016): 141–46. http://dx.doi.org/10.1017/ipm.2016.36.
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With the global ageing of our societies and the predicted increase of cognitive impairment and dementia, there is increasing interest in the role and scope of memory clinics or memory assessment services in the early assessment, diagnosis and management of all subtypes of dementia. Memory clinics generally attempt to provide a multidisciplinary approach to the diagnosis and treatment of memory impairment and dementia. However, little consensus exists about the profile or complement of staff that would constitute an ideal memory clinic, and services vary widely in terms of their organisation, remit and functioning. The purpose of this article is to highlight the variation amongst the existing complement of memory clinics in Ireland. The 17 models are compared in terms of their core multidisciplinary service and services available on referral. The Irish National Dementia Strategy recommends a well-coordinated service that provides early diagnosis and treatment, and one with good links to local support agencies. However, many of the services in Ireland lack input from relevant allied health professionals. This article also focusses on one privately funded memory clinic in Ireland which aims to bridge the gap between accurate diagnosis, holistic assessment and follow-up through comprehensive multidisciplinary input. The challenges facing this service are discussed, with particular reference to the difficulties encountered when providing community follow-up by a private sector clinic.
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Ramsay, Neil, Gianluca Maresca, Vicki Tully, and Kevin Campbell. "Does a multidisciplinary approach have a beneficial effect on the development of a structured patient handover process between acute surgical wards in one of Scotland’s largest teaching hospitals?" BMJ Open Quality 7, no. 3 (July 2018): e000154. http://dx.doi.org/10.1136/bmjoq-2017-000154.
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BackgroundEffective handover is key in preventing harm. 1 In the Acute Surgical Receiving Unit of Ninewells Hospital, Dundee, large numbers of patients are transferred daily. However, lack of medical handover during transfer means important tasks are missed. Our aim was to understand and reflect on the current system and test changes to improve medical handover.AimOur aim was to ensure that 95% of patients being transferred from the Acute Surgical Receiving Unit receive a basic medical handover within 2 months.MethodsInitially, we collated issues that were missed when patients were transferred. These data coupled with questionnaire data from members of the team fed into the creation of a handover tool. We proposed to link our tool with the nursing handover, hence creating one unified handover tool. We completed six full Plan-Do-Study-Act (PDSA) cycles (two on communication to aide handover and four on the tool itself) to assess and develop our tool.ResultsBy our final PDSA cycle, 84% (33/39) of the patients had a handover, meaning no tasks were missed during transfer. After 4 months, 9 out of 10 staff felt that the introduction of the handover sheet made the handover process smoother and 8 out of 10 felt that the handover sheet improved patient safety and quality of care.ConclusionsImproving handover can be challenging. However, we have shown that a relatively simple intervention can help promote better practice. Challenges are still present as uptake was only 84%, so work still has to be done to improve this. A wider cultural change involving communication and education would be required to implement this tool more widely.
Dissertations / Theses on the topic "One-on-one aide"
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Perkins, Joel K. "Exploring Patterns in Due Process Hearing Decisions Regarding the Usage of One-on-One Inclusion Aides for Students with Disabilities." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6825.
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This study reviews due process hearing decisions from the years 2014 and 2015. This is primarily a legal analysis, specifically looking at legal and regulatory patterns regarding the provision of one-on-one special education aides for students with disabilities in general education settings. Our findings from the due process hearing decisions reveal that one-on-one aides for students with a wide variety of disabilities are being provided with greater frequency than we anticipated and that, specifically, behavioral aides are being provided for students with autism. Decisions of disabilities such as hearing impairment have higher provision rates, while other disabilities like autism and emotional disturbance do not see the same rate of provision. There are clear patterns of differences between the states in the number of cases that reach due process hearings and in the number of one-on-one aides provided.
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Wilkinson, Mary Ann. "The impact of neurolinguistic programming rapport skills training for registered nurses on one-on-one teaching of Acquired Immune Deficiency Syndrome prevention." Diss., Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/54461.
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Nurses teach to maintain health and prevent disease. Rapport and good communication skills are especially required when teaching such sensitive subjects as prevention of sexually transmitted diseases, including acquired immune deficiency syndrome (AIDS). Neurolinguistic programming (NLP) is a communication technique that proposes to enhance rapport. Rapport is enhanced by the use of a combination of verbal and nonverbal techniques where the individual is matched and mirrored by the interviewer and verbal communication follows the sensory system most preferred by the speaker.
The study investigated the effect of NLP as a rapport builder and teaching technique in one-on-one nurse-client teaching transactions including client satisfaction with the relationship and retention of knowledge of AIDS prevention information.
A quasi-experimental design was used. Volunteer nurses were trained to teach AIDS prevention. Their adult volunteer clients were the treatment group. The control group of clients were taught by the nurses using the basic AIDS prevention curriculum. The two groups were compared according to the results of pre-test/post-test knowledge scores and satisfaction ratings for the nurse teacher.
Data was analyzed using analysis of covariance and analysis of variance. There were no statistically significant differences between the two groups. Qualitative A data was collected after the completion of the teaching that supported usefulness of the techniques for teaching. Further studies were recommended.Ed. D.
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Ntshanga, Nandipa. "The effects of HIV/AIDS epidemic on teachers and learners of one secondary school in Mthatha District." Thesis, Walter Sisulu University, 2013. http://hdl.handle.net/11260/d1008205.
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The aim of this research study was to investigate the effects of HIV/AIDS on teachers and learners of one Secondary School in Mthatha District of Eastern Cape, South Africa. The research design used was a case study; both quantitative and qualitative techniques were employed. The research was conducted in one secondary school, where data was collected using the interview schedules and the questionnaires. The teachers and learners were the respondents. Close-ended responses were analysed using Statistical Programme for Social Sciences (SPSS) computer software. Open-ended responses and interviews were analysed manually using sentence analysis, themes, categories and pattern. Interview responses were also analysed and interpreted using descriptions. From the analysis and interpretation of results, the following main findings emerged: HIV/AIDS has a devastating and deadly effect on both learners and teachers such as:-early sick pensions, redeployments, high teacher death rate, high learner death rate and learner absenteeism. Learner and teacher absenteeism trough HIV/AIDS epidemic, learner drop-out from school because of HIV/AIDS, non-fulfillment of future goals by the learners were discovered by the researcher as some of the findings from the study. From the findings it emerged that HIV/AIDS has devastating and deadly effect on both learners and educators. Support on those who are affected by HIV/AIDS epidemic is recommended by the researcher and the strategies that can be used to control HIV/AIDS epidemic.
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Pendukeni, Monika. "The impact of HIV/AIDS on health care provision: Perceptions on nurses currently working in one regional hospital in Namibia." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&.
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Studies on the impact of HIV/AIDS on health workers conducted in the health sector in different countries in Southern Africa have shown that health workers are affected and infected by HIV/AIDS. This has affected the provision of care rendered by nurses negatively. The high workload emanating from increased numbers of patients contributed to the situation. As a result, a number of nurses suffer from stress related illnesses caused by many factors such as fear of contracting the HIV virus. Low staff morale has also been observed among nurses. The aim of this study was to study nurses perceptions, views and suggestions on the impacts of HIV/AIDS on the provision of health care in terms of increased workload, stress, low morale and fear of contracting HIV/AIDS in two medical wards and a TB ward in one regional hospital in Namibia.
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Gurupira, Wilfred T. "Barriers to condom use in serodiscordant couples where one partner was on ART at the UZ Clinical Research Centre, Harare, Zimbabwe." University of the Western Cape, 2016. http://hdl.handle.net/11394/4994.
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Magister Public Health - MPHThe HIV prevalence rate in Zimbabwe has been estimated at 15% (15 years old and above), which is one of the highest in the world, and HIV/AIDS remains a significant public health problem. The focus of HIV prevention strategies has been on heterosexual transmission since this is the primary driver of the HIV epidemic in Zimbabwe. Heterosexual serodiscordant couples represent an important subpopulation for HIV prevention but are not well studied in Zimbabwe. In Harare almost all serodiscordant couples participating in the HPTN 052 study reported correct and consistent condom use. However, rates of STIs and pregnancies showed that couples in the study continued to have unprotected sex, in-spite of intensive couples’ counselling, quarterly follow up visits and provision of condoms. The aim of this qualitative study was to explore barriers to condom use by these serodiscordant couples in which one partner was on ART in Harare, Zimbabwe. It used a two stage qualitative approach with semi-structured interviews being the primary method of data collection. These interviews were conducted on a sample of five study staff, 15 serodiscordant couples and individuals enrolled in the HPTN 052 study in Harare, Zimbabwe after consent was obtained. Thematic analysis was used to analyse data collected.The study findings showed that partners were in a fairly large age range (30 to 50+ years) with males being slightly older than females. Seven males and five females were HIV positive. Couples had a wide variation in the length of their relationships, from one month to over 15 years as a couple. The study findings also showed that individuals in serodiscordant relationships understood serodiscordance. Problems unique to these couples were identified and broadly categorized as dealing with an HIV positive result, accepting serodiscordance, and difficulty of disclosing serodiscordance to family. Couples also showed understanding of the importance of condom use in a discordant relationship. The most common reason for using condoms was to prevent transmission of HIV to the uninfected partner. The main barriers to condom use were the strong desire to have children, male partner reluctance to use condoms and the influence of the negative partner in determining condom use. Based on these findings, a nuanced approach to prevention strategies, such as condom use and couples counselling and testing, is required. The aim should be to increase understanding of serodiscordance, risk and condom use at all sessions or contacts with couples.
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Kawooya, Tina. "One Sound Bite at a Time: Examining the Discourse of the Representation of People Living with HIV/AIDS on an Entertainment-Education Drama RockPoint 256." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24002.
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The objective of this thesis is to examine the meaning of the language used in an Entertainment-Education (E-E) radio serial drama RockPoint 256 (RP256) and its representation of People Living with HIV/AIDS (PLHA) and HIV/AIDS. The theoretical framework that is used to guide this study is the Cultural Studies perspective. Using Cultural Studies is instrumental to a study such as this that looks to find the source of meaning in RP256’s discourse (Hall, 1993, 105).
The methodological research design used is discourse analysis that examines the oral and written data of RP256. Discourse analysis “focuses on the way language is used, what it is used for, and the social context in which it is used” (Punch, 1998, 226). There were two types of discourse analyses used. Gee’s (1999) discourse analysis is used to analyse the linguistic nature of the texts at a micro level while, Fairclough’s (1989) discourse analysis is used to observe the overarching meaning of the discourse found in RP256 at the macro level.
The analysis of the data indicates that the representation of PLHA is a product of the societal and cultural markers that are a result of ideological labels given to HIV/AIDS and PLHA. The study concludes that PLHA are ostracised, stigmatized, live in poverty and are mostly women. The societal and cultural markers indicate that HIV/AIDS is still viewed as a plague and as a result PLHA are often silenced, marginalized, and discriminated against in Uganda.
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Tavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.
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O Vírus da Imunodeficiência Humana (HIV) é o agente etiológico da Síndrome da Imunodeficiência Adquirida (AIDS). A AIDS é uma doença de distribuição mundial, e estima-se que existam atualmente pelo menos 36,9 milhões de pessoas infectadas com o vírus. Durante o seu ciclo replicativo, o HIV promove diversas alterações na fisiologia da célula hospedeira a fim de promover sua sobrevivência e potencializar a replicação. A rápida progressão da infecção pelo HIV-1 em humanos e em modelos animais está intimamente ligada à função da proteína acessória Nef. Dentre as diversas ações de Nef está a regulação negativa de proteínas importantes na resposta imunológica, como o receptor CD4. Sabe-se que esta ação resulta da indução da degradação de CD4 em lisossomos, mas os mecanismos moleculares envolvidos ainda são totalmente elucidados. Nef forma um complexo tripartite com a cauda citosólica de CD4 e a proteína adaptadora 2 (AP-2), em vesículas revestidas por clatrina nascentes, induzindo a internalização e degradação lisossomal de CD4. Pesquisas anteriores demonstraram que o direcionamento de CD4 aos lisossomos por Nef envolve a entrada do receptor na via dos corpos multivesiculares (MVBs), por um mecanismo atípico, pois, embora não necessite da ubiquitinação de carga, depende da ação de proteínas que compõem os ESCRTs (Endosomal Sorting Complexes Required for Transport) e da ação de Alix, uma proteína acessória da maquinaria ESCRT. Já foi reportado que Nef interage com subunidades dos complexos AP-1, AP-2, AP-3 e Nef não parece interagir com subunidades de AP-4 e AP-5. Entretanto, o papel da interação de Nef com AP-1 e AP-3 na regulação negativa de CD4 ainda não está totalmente elucidado. Ademais, AP-1, AP-2 e AP-3 são potencialmente heterogêneos devido à existência de isoformas múltiplas das subunidades codificadas por diferentes genes. Todavia, existem poucos estudos para demonstrar se as diferentes combinações de isoformas dos APs são formadas e se possuem propriedades funcionais distintas. O presente trabalho procurou identificar e caracterizar fatores celulares envolvidos na regulação do tráfego intracelular de proteínas no processo de regulação negativa de CD4 induzido por Nef. Mais especificamente, este estudo buscou caracterizar a participação do complexo AP-1 na modulação negativa de CD4 por Nef de HIV-1, através do estudo funcional das duas isoformas de ?-adaptina, subunidades de AP-1. Utilizando a técnica de Pull-down demonstramos que Nef é capaz de interagir com ?2. Além disso, nossos dados de Imunoblot indicaram que a proteína ?2-adaptina, e não ?1-adaptina, é necessária no processo de degradação lisossomal de CD4 por Nef e que esta participação é conservada para degradação de CD4 por Nef de diferentes cepas virais. Ademais, por citometria de fluxo, o silenciamento de ?2, e não de ?1, compromete a diminuição dos níveis de CD4 por Nef da membrana plasmática. A análise por imunofluorêsncia indireta também revelou que a diminuição dos níveis de ?2 impede a redistribuição de CD4 por Nef para regiões perinucleares, acarretando no acúmulo de CD4, retirados por Nef da membrana plasmática, em endossomos primários. A depleção de ?1A, outra subunidade de AP-1, acarretou na diminuição dos níveis celulares de ?2 e ?1, bem como, no comprometimento da eficiente degradação de CD4 por Nef. Além disso, foi possível observar que, ao perturbar a maquinaria ESCRT via super-expressão de HRS (uma subunidade do complexo ESCRT-0), ocorreu um acumulo de ?2 em endossomos dilatados contendo HRS-GFP, nos quais também detectou-se CD4 que foi internalizado por Nef. Em conjunto, os resultados indicam que ?2-adaptina é uma importante molécula para o direcionamento de CD4 por Nef para a via ESCRT/MVB, mostrando ser uma proteína relevante no sistema endo-lisossomal. Ademais, os resultados indicaram que as isoformas ?-adaptinas não só possuem funções distintas, mas também parecem compor complexos AP-1 com diferentes funções celulares, já que apenas a variante AP-1 contendo ?2, mas não ?1, participa da regulação negativa de CD4 por Nef. Estes estudos contribuem para o melhor entendimento dos mecanismos moleculares envolvidos na atividade de Nef, que poderão também ajudar na melhor compreensão da patogênese do HIV e da síndrome relacionada. Em adição, este trabalho contribui para o entendimento de processos fundamentais da regulação do tráfego de proteínas transmembrana no sistema endo-lisossomal.The Human Immunodeficiency Virus (HIV) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a disease which has a global distribution, and it is estimated that there are currently at least 36.9 million people infected with the virus. During the replication cycle, HIV promotes several changes in the physiology of the host cell to promote their survival and enhance replication. The fast progression of HIV-1 in humans and animal models is closely linked to the function of an accessory protein Nef. Among several actions of Nef, one is the most important is the down-regulation of proteins from the immune response, such as the CD4 receptor. It is known that this action causes CD4 degradation in lysosome, but the molecular mechanisms are still incompletely understood. Nef forms a tripartite complex with the cytosolic tail of the CD4 and adapter protein 2 (AP-2) in clathrin-coated vesicles, inducing CD4 internalization and lysosome degradation. Previous research has demonstrated that CD4 target to lysosomes by Nef involves targeting of this receptor to multivesicular bodies (MVBs) pathway by an atypical mechanism because, although not need charging ubiquitination, depends on the proteins from ESCRTs (Endosomal Sorting Complexes Required for Transport) machinery and the action of Alix, an accessory protein ESCRT machinery. It has been reported that Nef interacts with subunits of AP- 1, AP-2, AP-3 complexes and Nef does not appear to interact with AP-4 and AP-5 subunits. However, the role of Nef interaction with AP-1 or AP-3 in CD4 down-regulation is poorly understood. Furthermore, AP-1, AP-2 and AP-3 are potentially heterogeneous due to the existence of multiple subunits isoforms encoded by different genes. However, there are few studies to demonstrate if the different combinations of APs isoforms are form and if they have distinct functional properties. This study aim to identify and characterize cellular factors involved on CD4 down-modulation induced by Nef from HIV-1. More specifically, this study aimed to characterize the involvement of AP-1 complex in the down-regulation of CD4 by Nef HIV-1 through the functional study of the two isoforms of ?-adaptins, AP-1 subunits. By pull-down technique, we showed that Nef is able to interact with ?2. In addition, our data from immunoblots indicated that ?2- adaptin, not ?1-adaptin, is required in Nef-mediated targeting of CD4 to lysosomes and the ?2 participation in this process is conserved by Nef from different viral strains. Furthermore, by flow cytometry assay, ?2 depletion, but not ?1 depletion, compromises the reduction of surface CD4 levels induced by Nef. Immunofluorescence microscopy analysis also revealed that ?2 depletion impairs the redistribution of CD4 by Nef to juxtanuclear region, resulting in CD4 accumulation in primary endosomes. Knockdown of ?1A, another subunit of AP-1, resulted in decreased cellular levels of ?1 and ?2 and, compromising the efficient CD4 degradation by Nef. Moreover, upon artificially stabilizing ESCRT-I in early endosomes, via overexpression of HRS, internalized CD4 accumulates in enlarged HRS-GFP positive endosomes, where co-localize with ?2. Together, the results indicate that ?2-adaptin is a molecule that is essential for CD4 targeting by Nef to ESCRT/MVB pathway, being an important protein in the endo-lysosomal system. Furthermore, the results indicate that ?-adaptins isoforms not only have different functions, but also seem to compose AP-1 complex with distinct cell functions, and only the AP-1 variant comprising ?2, but not ?1, acts in the CD4 down-regulation induced by Nef. These studies contribute to a better understanding on the molecular mechanisms involved in Nef activities, which may also help to improve the understanding of the HIV pathogenesis and the related syndrome. In addition, this work contributes with the understanding of primordial process regulation on intracellular trafficking of transmembrane proteins.
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YANG, HSIN-CHING, and 楊欣靜. "A Research on One-Bit Precoder Design for Precoding-Aided Spatial Modulation." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/pu428x.
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碩士國立中正大學
通訊工程研究所
107
Precoders in existing precoding-aided spatial modulation (PSM) multiple-input multiple-output (MIMO) systems, such as minimum mean square error (MMSE) precoder and zero forcing (ZF) precoder, are often equipped with high-resolution DACs. As the power consumption of DACs grow exponentially with the resolution, high hardware complexity and excessive circuit power consumption is required in conventional design. In order to address this issue, we propose to design the precoder of a PSM-MIMO system facilitating the use of 1-bit DACs at the transmitter. In this thesis, we propose two precoder designs for PSM-MIMO system under 1-bit DAC hardware constraints. Finally, numerical simulations ar performed to verify the bit error rate performance of our proposed one-bit precoders.
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Fourie, Pieter Paul. "One burden too many: public policy making on HIV/AIDS in South Africa, 1982-2004." Thesis, 2008. http://hdl.handle.net/10210/1369.
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D.Litt et Phil.According to the Joint United Nations Programme on HIV/AIDS, more than 5.3 million South Africans were HIV-positive at the end of 2003; AIDS is killing the population at a rate of around 1,000 people each day; and about 2,000 South Africans are becoming HIV-positive daily. This study is an enquiry into the public policy response to the South African epidemic. Since AIDS first appeared in the country in 1982 there have been numerous good policy documents written by successive South African governments—yet the epidemic shows little sign of abating. The study provides an overview of the main theories on public policy making, and applies these by combining a meso-level of analysis with a phase/stage approach to the policy process. It demonstrates that successive South African governments have defined the policy problem in different ways: moving from a moralistic to a biomedical approach, the most recent public policy response has been to (discursively at least) view the epidemic as a developmental and human rights-based problem. However, despite the drafting of broadly inclusive and well-conceptualised policies, previous as well as the current South African government suffers from a ‘crisis of implementation’. The study finds that this crisis of implementation is the result of a failure on the part of South African governments to consistently and correctly define the public policy problem itself. This has resulted in a contested policy environment, particularly in terms of the appropriate policy responses required. As a consequence, the initial close relationship between the new South African government and AIDS civil society has been badly eroded. The latter policy actor has turned to a strategy of bypassing the national government altogether, by appealing to the courts in an effort to ensure the implementation of AIDS policies. The study concludes that, unless public policy makers address the structural causes of the AIDS epidemic (race relations, sexual violence and cultural factors), the country will continue to suffer the ravages of the epidemic, nullifying some recent successes of lower levels of government (provinces and local governments) in demonstrating some implementation capacity. The study suggests that the public sector take greater cognisance of the tenets of different theories on public policy making in an effort to ameliorate the mistakes of the past.
Prof. Yolanda Sadie
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Chen, Wei-Lun, and 陳威倫. "A study on students’ knowledge, attitudes, and behavioral intentions on AIDS prevention at one junior high school in New Taipei City." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/18004848600721850734.
Full textAbstract:
碩士國立臺灣師範大學
健康促進與衛生教育學系
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The main purpose of this study is to investigate the knowledge of AIDS prevention, attitudes and behavioral intentions among junior high school students in New Taipei City. Participants were 7th and 8th grade students enrolled in a single junior high school in New Taipei City. A self-designed questionnaire was used to collect data. Contents included background information, knowledge, attitudes and behavioral intentions on AIDS prevention. A total of 458 effective questionnaires were collected. The results are summarized as follows: 1.Subjects had a median high level on AIDS prevention knowledge with an average score of 70.7%. Subjects' attitude toward AIDS prevention and acceptance of HIV- infected persons were positive. Subjects showed positive behavioral intensions of AIDS prevention but had less concern on HIV-infected persons. 2.Subjects' main information sources of AIDS came from teachers and expert speeches in school. Books and AIDS prevention guide were major information sources of print media. Internet and training videos were the main information sources of electronic media. 3.AIDS prevention knowledge had significant differences between grades; AIDS preventive behavioral intentions had significant differences between gender; AIDS prevention knowledge, attitudes and behavioral intentions had significant differences with subjects' grade point average in school. 4.AIDS prevention knowledge is positively correlated with attitudes and prevention behavioral intensions and the concern of persons with AIDS. 5.Gender, grade point average in school, AIDS prevention attitude and attitude to accept HIV-infected persons can effectively predict behavioral intentions. Among these factors, AIDS prevention attitude is the most influential; gender, AIDS prevention attitude and attitude to accept to HIV- infected persons can effectively predict the concern of persons with AIDS. Among these factors, attitude to accept HIV- infected persons is the most influential.
Books on the topic "One-on-one aide"
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United States. Congress. Senate. Select Committee on Indian Affairs. Field hearing--Anchorage, AK: Hearing before the Select Committee on Indian Affairs, United States Senate, One Hundredth Congress, second session, on oversight hearing on amendments to the Indian Child Welfare Act; eligibility for IHS health care services; funding for paraprofessional education personnel ... community health aide personnel; and community-based mental health initiative, September 2, 1988, Anchorage, AK. Washington: U.S. G.P.O., 1989.
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United States. Congress. Senate. Select Committee on Indian Affairs. Field hearing--Anchorage, AK: Hearing before the Select Committee on Indian Affairs, United States Senate, One Hundredth Congress, second session, on oversight hearing on amendments to the Indian Child Welfare Act; eligibility for IHS health care services; funding for paraprofessional education personnel ... community health aide personnel; and community-based mental health initiative, September 2, 1988, Anchorage, AK. Washington: U.S. G.P.O., 1989.
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United States. Congress. Senate. Select Committee on Indian Affairs. Field hearing--Anchorage, AK: Hearing before the Select Committee on Indian Affairs, United States Senate, One Hundredth Congress, second session, on oversight hearing on amendments to the Indian Child Welfare Act; eligibility for IHS health care services; funding for paraprofessional education personnel ... community health aide personnel; and community-based mental health initiative, September 2, 1988, Anchorage, AK. Washington: U.S. G.P.O., 1989.
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United States. Congress. Senate. Select Committee on Indian Affairs. Field hearing--Anchorage, AK: Hearing before the Select Committee on Indian Affairs, United States Senate, One Hundredth Congress, second session, on oversight hearing on amendments to the Indian Child Welfare Act; eligibility for IHS health care services; funding for paraprofessional education personnel ... community health aide personnel; and community-based mental health initiative, September 2, 1988, Anchorage, AK. Washington: U.S. G.P.O., 1989.
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United States. Congress. Senate. Select Committee on Indian Affairs. Field hearing--Anchorage, AK: Hearing before the Select Committee on Indian Affairs, United States Senate, One Hundredth Congress, second session, on oversight hearing on amendments to the Indian Child Welfare Act; eligibility for IHS health care services; funding for paraprofessional education personnel ... community health aide personnel; and community-based mental health initiative, September 2, 1988, Anchorage, AK. Washington: U.S. G.P.O., 1989.
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United States. Congress. Senate. Select Committee on Indian Affairs. Field hearing--Anchorage, AK: Hearing before the Select Committee on Indian Affairs, United States Senate, One Hundredth Congress, second session, on oversight hearing on amendments to the Indian Child Welfare Act; eligibility for IHS health care services; funding for paraprofessional education personnel ... community health aide personnel; and community-based mental health initiative, September 2, 1988, Anchorage, AK. Washington: U.S. G.P.O., 1989.
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United States. Congress. Senate. Select Committee on Indian Affairs. Field hearing--Anchorage, AK: Hearing before the Select Committee on Indian Affairs, United States Senate, One Hundredth Congress, second session, on oversight hearing on amendments to the Indian Child Welfare Act; eligibility for IHS health care services; funding for paraprofessional education personnel ... community health aide personnel; and community-based mental health initiative, September 2, 1988, Anchorage, AK. Washington: U.S. G.P.O., 1989.
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Affairs, United States Congress Senate Select Committee on Indian. Field hearing--Anchorage, AK: Hearing before the Select Committee on Indian Affairs, United States Senate, One Hundredth Congress, second session, on oversight hearing on amendments to the Indian Child Welfare Act; eligibility for IHS health care services; funding for paraprofessional education personnel ... community health aide personnel; and community-based mental health initiative, September 2, 1988, Anchorage, AK. Washington: U.S. G.P.O., 1989.
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United States. Congress. Senate. Select Committee on Indian Affairs. Field hearing--Anchorage, AK: Hearing before the Select Committee on Indian Affairs, United States Senate, One Hundredth Congress, second session, on oversight hearing on amendments to the Indian Child Welfare Act; eligibility for IHS health care services; funding for paraprofessional education personnel ... community health aide personnel; and community-based mental health initiative, September 2, 1988, Anchorage, AK. Washington: U.S. G.P.O., 1989.
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One, Day Seminar on Finding Aids to South Asian Research Materials (1995 Islamabad Pakistan). One Day Seminar on Finding Aids to South Asian Research Materials. [Karachi: National Documentation Centre], 1995.
Find full textBook chapters on the topic "One-on-one aide"
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Peled, Doron. "All from one, one for all: on model checking using representatives." In Computer Aided Verification, 409–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/3-540-56922-7_34.
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Gardner, Philippa, Gareth Smith, Conrad Watt, and Thomas Wood. "A Trusted Mechanised Specification of JavaScript: One Year On." In Computer Aided Verification, 3–10. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21690-4_1.
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Abundo, Mario, and Maria Beatrice Scioscia Santoro. "On the Successive Passage Times of Certain One-Dimensional Diffusions." In Computer Aided Systems Theory – EUROCAST 2019, 195–203. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45093-9_24.
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Stewart, Alistair, Kousha Etessami, and Mihalis Yannakakis. "Upper Bounds for Newton’s Method on Monotone Polynomial Systems, and P-Time Model Checking of Probabilistic One-Counter Automata." In Computer Aided Verification, 495–510. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-39799-8_33.
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Gordon, Gill. "7. ‘One finger cannot kill a louse’ – working with schools on gender, sexuality, and HIV in rural Zambia." In Gender Equality HIV, and AIDS, 129–49. UK and Ireland: Oxfam Publishing, 2008. http://dx.doi.org/10.3362/9780855987480.007.
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Greblicki, Jerzy, and Jerzy Kotowski. "Analysis of the Properties of the Harmony Search Algorithm Carried Out on the One Dimensional Binary Knapsack Problem." In Computer Aided Systems Theory - EUROCAST 2009, 697–704. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-04772-5_90.
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Pereira, Mário, and António Ravara. "Cameleer: A Deductive Verification Tool for OCaml." In Computer Aided Verification, 677–89. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-81688-9_31.
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AbstractWe present , an automated deductive verification tool for OCaml. We leverage on the recently proposed GOSPEL (Generic OCaml SPEcification Language) to attach rigorous, yet readable, behavioral specification to OCaml code. The formally-specified program is fed to our toolchain, which translates it into an equivalent one in WhyML, the programming and specification language of the Why3 verification framework. We report on successful case studies conducted in .
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Wang, Qiuye, Mingshuai Chen, Bai Xue, Naijun Zhan, and Joost-Pieter Katoen. "Synthesizing Invariant Barrier Certificates via Difference-of-Convex Programming." In Computer Aided Verification, 443–66. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-81685-8_21.
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AbstractA barrier certificate often serves as an inductive invariant that isolates an unsafe region from the reachable set of states, and hence is widely used in proving safety of hybrid systems possibly over the infinite time horizon. We present a novel condition on barrier certificates, termed the invariant barrier-certificate condition, that witnesses unbounded-time safety of differential dynamical systems. The proposed condition is by far the least conservative one on barrier certificates, and can be shown as the weakest possible one to attain inductive invariance. We show that discharging the invariant barrier-certificate condition—thereby synthesizing invariant barrier certificates—can be encoded as solving an optimization problem subject to bilinear matrix inequalities (BMIs). We further propose a synthesis algorithm based on difference-of-convex programming, which approaches a local optimum of the BMI problem via solving a series of convex optimization problems. This algorithm is incorporated in a branch-and-bound framework that searches for the global optimum in a divide-and-conquer fashion. We present a weak completeness result of our method, in the sense that a barrier certificate is guaranteed to be found (under some mild assumptions) whenever there exists an inductive invariant (in the form of a given template) that suffices to certify safety of the system. Experimental results on benchmark examples demonstrate the effectiveness and efficiency of our approach.
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Yu, Emily, Armin Biere, and Keijo Heljanko. "Progress in Certifying Hardware Model Checking Results." In Computer Aided Verification, 363–86. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-81688-9_17.
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AbstractWe present a formal framework to certify k-induction-based model checking results. The key idea is the notion of a k-witness circuit which simulates the given circuit and has a simple inductive invariant serving as proof certificate. Our approach allows to check proofs with an independent proof checker by reducing the certification problem to pure SAT checks and checking a simple QBF with one quantifier alternation. We also present Certifaiger, the resulting certification toolkit, and evaluate it on instances from the hardware model checking competition. Our experiments show the practical use of our certification method.
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D’Antoni, Loris, Qinheping Hu, Jinwoo Kim, and Thomas Reps. "Programmable Program Synthesis." In Computer Aided Verification, 84–109. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-81685-8_4.
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AbstractProgram synthesis is now a reality, and we are approaching the point where domain-specific synthesizers can now handle problems of practical sizes. Moreover, some of these tools are finding adoption in industry. However, for synthesis to become a mainstream technique adopted at large by programmers as well as by end-users, we need to design programmable synthesis frameworks that (i) are not tailored to specific domains or languages, (ii) enable one to specify synthesis problems with a variety of qualitative and quantitative objectives in mind, and (iii) come equipped with theoretical as well as practical guarantees. We report on our work on designing such frameworks and on building synthesis engines that can handle program-synthesis problems describable in such frameworks, and describe open challenges and opportunities.
Conference papers on the topic "One-on-one aide"
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Fannon, David, and Michelle Laboy. "Resilient Homes Online Design Aide: Connecting Research and Practice for Socially Resilient Communities." In 2018 Intersections. ACSA Press, 2018. http://dx.doi.org/10.35483/acsa.aia.inter.18.2.
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Resilience in architectural research, discourse, and practice tends to focus on physical aspects of the built environment. Much of the discussion within this technological domain of resilience resolves around singular, unique, and high value facilities: ignoring the vast fabric of buildings where most people live. However, studies in socioecological resilience suggests that resilience in the built environment must address people and systems, not merely property. Transitioning to this focus will both require and result in broadening architecture’s interest and influence beyond the normal physical boundaries of the built environment. To effectively engage this broader scope, new tools must enable new modes of public outreach, information sharing, data analysis, decision support, and ultimately create new knowledge. This paper describes the motivation, development, and preliminary findings of one such tool, the Resilient Home Online Design Aide (RHOnDA). This results suggest a cycle of participatory architectural research to advance socioecological resilience.
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Mulej, Matjaž, Zdenka Zenko, and Vojko Potocan. "The Visionary Companies, an Excellent Case of the Informal Systems Thinking." In 2002 Informing Science + IT Education Conference. Informing Science Institute, 2002. http://dx.doi.org/10.28945/2543.
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Systems theory has become a worldview aimed at holism, and a methodology supportive of holism. But it has also become a sophisticated mathematical and philosophical approach, which limits it to rather few intellectuals and systems theorists. This is not enough for humankind to do well. An insight into the most successful companies, called the visionary companies in the analysis briefed here, let us see that an informal, implicit, indirect, systems thinking might be as important as the systems theory (which still remains important as its aide). The point is double, at least: (1) systems thinking practices holistic thinking that implicitly attains the requisite holism on a high level, (2) systems theory is not a theory aimed at itself, but at supporting the holistic rather than one-sided thinking, by building bridges between mutually different specialists. Informal, implicit systems thinking can do equally much good as the one backed by systems theory.
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Wei, Qi, Bibo Shi, Joseph Y. Lo, Lawrence Carin, Yinhao Ren, and Rui Hou. "Anomaly detection for medical images based on a one-class classification." In Computer-Aided Diagnosis, edited by Kensaku Mori and Nicholas Petrick. SPIE, 2018. http://dx.doi.org/10.1117/12.2293408.
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Mahmoud, Abdelrahman, Mohammed Naser, Mahmoud Abdelrasool, Khalid Jama, Mohamed Hussein, Asma Abdulkareem, Peter Kasak, and Anton Popelka. "Development of PLA Fibers as an Antimicrobial Agent with Enhanced Infection Resistance using Electrospinning/Plasma Technology." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0079.
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Humans are vulnerable and easily prone to all kind of injuries, diseases, and traumas that can be damaging to their tissues (including its building unit, cells), bones, or even organs. Therefore, they would need assistance in healing or re-growing once again. Medical scaffolds have emerged over the past decades as one of the most important concepts in the tissue-engineering field as they enable and aide the re-growth of tissues and their successors. An optimal medical scaffold should be addressing the following factors: biocompatibility, biodegradability, mechanical properties, scaffold architecture/porosity, precise three-dimensional shape and manufacturing technology. There are several materials utilized in the fabrication of medical scaffolds, but one of the most extensively studied polymers is polylactic acid (PLA). PLA is biodegradable thermoplastic aliphatic polyester that is derived from naturally produced lactic acid. PLA is characterized with its excellent mechanical properties, biodegradability, promising eco-friendly, and excellent biocompatibility. PLA can be fabricated into nanofibers for medical scaffolds used through many techniques; electrospinning is one of the widely used methods for such fabrication. Electrospinning is a favorable technique because in the preparation of scaffolds, some parameters such as fiber dimensions, morphology, and porosity are easily controlled. A problem that is associated with medical scaffolds, such as inflammation and infection, was reported in many cases resulting in a degradation of tissues. Therefore, a surface modification was thought of as a needed solution which mostly focuses on an incorporation of extra functionalities responsible for the surface free energy increase (wettability). Therefore, plasma technique was a favorable solution for the surface treatment and modification. Plasma treatment enables the formation of free radicals. These radicals can be easily utilized for grafting process. Subsequently, ascorbic acid (ASA) could be incorporated as anti-inflammatory and anti-infection agent on the plasma pretreated surface of scaffolds.
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Xu, Xiao, Qingjun Zhao, Weiwei Luo, Fei Tang, and Xiaolei Sun. "Research on the Matching Relationship Between HPT and LPT of One and One-Half Vaneless Contra-Rotating Turbines." In ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/gt2016-56141.
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The vaneless contra-rotating turbine (VCRT) has the potential to improve the thrust-to-weight ratio for future high performance propulsion systems. Without the inter-stage vane, the variation of the high pressure turbine (HPT) exit swirl, under off-design conditions, can introduce more significant effects on the operation of the low pressure turbine (LPT). This study performed both analytical and numerical work investigating the matching relationship between the two stages of one and one-half stage (1+1/2) VCRTs. The significant difference of 1+1/2 VCRTs from conventional turbines, under choking geometry-fixed conditions, was found the flow capacity at the station between HPT and LPT is not invariant. The matching relationship between HPT and LPT is indeed how the flow capacity at the station between the two stages varies for different matching conditions. Influenced by the variation of the flow capacity, both the total pressure ratio of HPT and the corrected mass flow rate at the inlet of LPT are confined by the matching relationship. The corrected rotational speeds of the two stages define different matching conditions. A correlation, defining the matching conditions that LPT can work with constant incidence, was also derived. With aid of the correlation, the matching conditions can be controlled assuring LPT work with stable high efficiency. In the end, an application of incorporating the matching relationship into the investigation of engine performances is demonstrated, in which, a turbojet performance cycle analysis was performed. This paper has established a framework guiding how to obtain the matching relationship between the two stages of 1+1/2 VCRTs and incorporate it into the investigation of engine performances.
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Wandt, R., A. Friedewald, and H. Lodding. "Simulation aided disturbance management in one-of-a-kind production on the assembly site." In 2012 IEEE International Conference on Industrial Engineering and Engineering Management (IEEM). IEEE, 2012. http://dx.doi.org/10.1109/ieem.2012.6837790.
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Payton, Lewis N. "Friction Stir Welding of Aluminum 6061-T6 and Multi-Purpose Copper 11000 Alloy." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-71411.
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Friction Stir Welding (FSW) is a solid-state joining process invented by The Welding Institute (TWI, United Kingdom) in 1991 in partnership with the National Aeronautics Space Agency. The process is emerging as one of the preferred alternative methods to permanently join materials that are difficult to join with traditional fusion methods (e.g., MIG, TIG, etc.). The welding of various copper alloys to various aluminum alloys is of great interest to the nuclear industry and the electrical distribution industry. The very different melting points of these two alloys preclude traditional fusion welding. Since the pin tool is simultaneously rotating and traversing through the work piece, flow around the tool is asymmetrical. This has led to designating one side of the tool as advancing and the opposite side as retreating. On the advancing side of the weld, the tool has a tangential velocity in the same direction as the weld is being created. The retreating side of the weld tool is the opposite. It can be can expected that asymmetric heating and deformation will occur in the weld due to this advancing/retreating nature of the FSW pin tool. Although previous studies have been performed that have observed this asymmetric behavior in both similar and dissimilar materials, the resulting welds have been of a poor quality. Large statistical experiments were conducted locally to study the effects of tool geometry, process parameters, and material composition have upon the friction stir butt welding of aluminum alloy 6061-T6 to copper alloy 11000 using a modern conventional 3-axis CNC vertical mill. The research seeks to determine (1) which direction a dissimilar metal friction stir weld between aluminum and copper should be executed, (2) the optimal shoulder diameter to be used when friction stir welding aluminum and copper on a CNC mill, and (3) the addition of a third material to act as an aide. The extensive statistical interactions between these parameters is also documented. A weld schedule was developed that resulted in an ultimate tensile strength (UTS) surpassing (greater than 90% of the weaker, more ductile copper alloy UTS strength) what has been documented in the current literature despite the machine limitations of the CNC vertical mill. Proper optimization of the welding schedule developed may approach 100 percent of the basic copper 11000 properties across the welded zone into the aluminum 6061-T6 alloy.
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Hu, J. B., C. B. Liu, Z. Y. Wang, S. H. Wu, and W. Huang. "Improvement on the three-step haze removal technique with the aid of one clear image partly overlapped." In 2010 18th International Conference on Geoinformatics. IEEE, 2010. http://dx.doi.org/10.1109/geoinformatics.2010.5567716.
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Das, Pratyusha, Subhrajit Mukherjee, Samit K. Ray, and Shivakiran Bhaktha B N. "Optical Tamm States Aided Random Laser Emission in Dye-Doped Polymer Films Deposited on One-dimensional Photonic Crystals." In International Conference on Fibre Optics and Photonics. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/photonics.2016.w3a.66.
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Syahlani, Ahmad, Tanwiriah Tanwiriah, and Abdul Latif. "Effectiveness Of Health Promotion Through The Audio Visual Media Risk Of Transmission Of Hiv / Aids On The Motivation Of Youth In Sman 10 Banjarmasin." In 2nd Sari Mulia International Conference on Health and Sciences 2017 (SMICHS 2017) � One Health to Address the Problem of Tropical Infectious Diseases in Indonesia. Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/smichs-17.2017.60.
Full textReports on the topic "One-on-one aide"
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for Development Programme, Knowledge. Using Indices to Capture Vulnerability for Development Finance in SIDS. Institute of Development Studies (IDS), April 2019. http://dx.doi.org/10.19088/k4d.2021.066.
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This rapid review examines evidence on indices to capture vulnerability for development finance in Small Island Developing States (SIDS). A key issue when it comes to aid allocation to Small Island Developing States (SIDS) is whether current measures of development – such as income per capita - are truly able to reflect the unique set of challenges that these countries face. Inability to accurately measure development in SIDS can lead to substantial risk. On the one hand, aid allocation that solely relies on income levels may result in an unsustainable reduction in external support to SIDS, leaving them to face high levels of economic, environmental, and social vulnerability. On the other hand, an inadequate measure of vulnerability can lead to no clear pathway to the reduction in aid, making it very improbable for SIDS to become self-reliant, no matter how far they develop or climb the income ladder. This aim of this paper is twofold. The first is to look at whether vulnerability indices can help determine the levels of external support SIDS need. The second is to consider how this can help in determining when support can be reduced or terminated. This is achieved by considering the different indices that international organisations and multilateral development banks use to capture the vulnerability of SIDS, how they use these indices to determine thresholds for aid allocation, and the advantages and disadvantages of applying each.
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Ismail, Zenobia, and Topua Lesinko. Interventions to Address Discrimination against LGBTQi Persons. Institute of Development Studies (IDS), June 2021. http://dx.doi.org/10.19088/k4d.2021.104.
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This annotated bibliography synthesises evidence on interventions to limit discrimination and abuse against people who are LGBTQi. In general, development agencies have strong commitments to LGBTQi rights in their strategy and policy documents. However, they avoid addressing LGBTQi rights directly through programming. Historically, international donor support for LGBTQi rights has been channelled through health programmes (especially those related to sexual health or HIV/AIDS) and democracy and governance support programmes. Recently, there is a trend towards integrating LGBTQi rights across a broader set of development programmes under the auspices of “leave no one behind”. The literature notes some barriers that undermine the extent to which international development interventions or programmes can address discrimination against LGBTQi persons. One of the barriers includes LGBTQi rights are still not viewed as a development priority but as a controversy in some settings, leading embassies to be hesitant to engage with them. Limited data and understanding of the various issues that are categorised as LGBTQi curtail the extent to which these issues can be integrated with other development programmes. The literature also observes that prejudice among staff at all levels in development agencies undermines their willingness to engage with LGBTQi rights and issues.
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Groeneveld, Andrew B., Stephanie G. Wood, and Edgardo Ruiz. Estimating Bridge Reliability by Using Bayesian Networks. Engineer Research and Development Center (U.S.), February 2021. http://dx.doi.org/10.21079/11681/39601.
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As part of an inspection, bridge inspectors assign condition ratings to the main components of a bridge’s structural system and identify any defects that they observe. Condition ratings are necessarily somewhat subjective, as they are influenced by the experience of the inspectors. In the current work, procedures were developed for making inferences on the reliability of reinforced concrete girders with defects at both the cross section and the girder level. The Bayesian network (BN) tools constructed in this work use simple structural m echanics to model the capacity of girders. By using expert elicitation, defects observed during inspection are correlated with underlying deterioration mechanisms. By linking these deterioration mechanisms with reductions in mechanical properties, inferences on the reliability of a bridge can be made based on visual observation of defects. With more development, this BN tool can be used to compare conditions of bridges relative to one another and aid in the prioritization of repairs. However, an extensive survey of bridges affected by deterioration mechanisms is needed to confidently establish valid relationships between deterioration severity and mechanical properties.
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Montefusco, Maria, and Kai Koivumäki. Nordic indicators for cooperation on disability – Monitoring the implementation of UNCRPD and Agenda 2030. Edited by Christina Lindström. Nordens välfärdscenter, June 2021. http://dx.doi.org/10.52746/ovbi5427.
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No person with a disability shall be left behind. This report presents suggested indicators for monitoring the implementation of the UN Convention on the Rights of Persons with Disability and Agenda 2030 in the Nordic region. The vision of the Nordic cooperation is to become the most integrated and sustainable in the world by 2030. The vision mirrors the sustainable development goals of Agenda 2030, according to which no-one shall be left behind. Persons with disabilities have the right to inclusion, and the Nordic countries monitor the developments of living conditions for persons with disabilities. All countries have also ratified the Convention on the rights of persons with disabilities and have high ambitions with regard to Agenda 2030. Throughout the region we face similar challenges concerning inclusion. Participation is not equal, not in employment, nor in education, economy, or health. But to improve this we need to see it. Even if a set of indicators is not the only way forward, they can help us measure if we are on the right track. In this report, we suggest a set of indicators that could be developed further and used to follow the developments towards inclusion and measure living conditions. By developing such a set of comparable indicators in the Nordic countries, we can see whether the countries separately and collectively follow the intentions of the UNCRPD to improve the living conditions of people with disabilities. The indicators are also an aid in the work to identify whether we are working correctly to achieve the Agenda 2030 targets.
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Scoular, Claire, and Ian Teo. Developing strategic plans for an aligned approach to 21st century skills integration. Australian Council for Educational Research, March 2021. http://dx.doi.org/10.37517/978-1-74286-626-0.
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This report describes an online course developed to support education systems to build an aligned and sustainable approach to integration of 21st Century Skills (21CS). 21CS are those skills that are considered particularly important to succeed in today’s knowledge-based society in which innovation and technology are predominant. Prominent examples include critical thinking, creative thinking, and collaboration, and such skills need to be better understood in order for them to be integrated. While different countries may have their own frameworks or priorities surrounding 21CS, a consistent approach to integration can still be achieved with a shared understanding from all stakeholders within the system. The course objectives focused on supporting countries to develop a strategic plan for 21CS integration, providing resources to aid that plan, and building capacity to implement the plan. The specific learning objectives were to: Understand components and steps leading to 21CS alignment; Conduct a needs analysis, identifying which steps are currently being met, and which steps need more attention; Develop a strategic plan, identifying which steps are to be prioritized and in which order; Gain insights from other education systems from reflections on successful developments and lessons learned; and Engage in discussion within education systems and with other countries about the emerging area of skills integration, as well as identify future directions. Course participants joined from across 16 Asia Pacific countries and from the Education Quality and Assessment Programme for the Pacific Community (EQAP). The course comprised of eight modules that were spread over three weeks, with content hosted online through the Moodle platform.Each module consisted of pre-recorded video content (30-60 minutes) and team and/or individual activities. The modules were supported by three live sessions that allowed participants to ask questions and share reflections in real time. The course concluded with a webinar that consisted of presentations that were delivered by one member from each Core Strategy Team who shared their team’s strategic plan and reflections from this course.
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Treadwell, Jonathan R., James T. Reston, Benjamin Rouse, Joann Fontanarosa, Neha Patel, and Nikhil K. Mull. Automated-Entry Patient-Generated Health Data for Chronic Conditions: The Evidence on Health Outcomes. Agency for Healthcare Research and Quality (AHRQ), March 2021. http://dx.doi.org/10.23970/ahrqepctb38.
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Background. Automated-entry consumer devices that collect and transmit patient-generated health data (PGHD) are being evaluated as potential tools to aid in the management of chronic diseases. The need exists to evaluate the evidence regarding consumer PGHD technologies, particularly for devices that have not gone through Food and Drug Administration evaluation. Purpose. To summarize the research related to automated-entry consumer health technologies that provide PGHD for the prevention or management of 11 chronic diseases. Methods. The project scope was determined through discussions with Key Informants. We searched MEDLINE and EMBASE (via EMBASE.com), In-Process MEDLINE and PubMed unique content (via PubMed.gov), and the Cochrane Database of Systematic Reviews for systematic reviews or controlled trials. We also searched ClinicalTrials.gov for ongoing studies. We assessed risk of bias and extracted data on health outcomes, surrogate outcomes, usability, sustainability, cost-effectiveness outcomes (quantifying the tradeoffs between health effects and cost), process outcomes, and other characteristics related to PGHD technologies. For isolated effects on health outcomes, we classified the results in one of four categories: (1) likely no effect, (2) unclear, (3) possible positive effect, or (4) likely positive effect. When we categorized the data as “unclear” based solely on health outcomes, we then examined and classified surrogate outcomes for that particular clinical condition. Findings. We identified 114 unique studies that met inclusion criteria. The largest number of studies addressed patients with hypertension (51 studies) and obesity (43 studies). Eighty-four trials used a single PGHD device, 23 used 2 PGHD devices, and the other 7 used 3 or more PGHD devices. Pedometers, blood pressure (BP) monitors, and scales were commonly used in the same studies. Overall, we found a “possible positive effect” of PGHD interventions on health outcomes for coronary artery disease, heart failure, and asthma. For obesity, we rated the health outcomes as unclear, and the surrogate outcomes (body mass index/weight) as likely no effect. For hypertension, we rated the health outcomes as unclear, and the surrogate outcomes (systolic BP/diastolic BP) as possible positive effect. For cardiac arrhythmias or conduction abnormalities we rated the health outcomes as unclear and the surrogate outcome (time to arrhythmia detection) as likely positive effect. The findings were “unclear” regarding PGHD interventions for diabetes prevention, sleep apnea, stroke, Parkinson’s disease, and chronic obstructive pulmonary disease. Most studies did not report harms related to PGHD interventions; the relatively few harms reported were minor and transient, with event rates usually comparable to harms in the control groups. Few studies reported cost-effectiveness analyses, and only for PGHD interventions for hypertension, coronary artery disease, and chronic obstructive pulmonary disease; the findings were variable across different chronic conditions and devices. Patient adherence to PGHD interventions was highly variable across studies, but patient acceptance/satisfaction and usability was generally fair to good. However, device engineers independently evaluated consumer wearable and handheld BP monitors and considered the user experience to be poor, while their assessment of smartphone-based electrocardiogram monitors found the user experience to be good. Student volunteers involved in device usability testing of the Weight Watchers Online app found it well-designed and relatively easy to use. Implications. Multiple randomized controlled trials (RCTs) have evaluated some PGHD technologies (e.g., pedometers, scales, BP monitors), particularly for obesity and hypertension, but health outcomes were generally underreported. We found evidence suggesting a possible positive effect of PGHD interventions on health outcomes for four chronic conditions. Lack of reporting of health outcomes and insufficient statistical power to assess these outcomes were the main reasons for “unclear” ratings. The majority of studies on PGHD technologies still focus on non-health-related outcomes. Future RCTs should focus on measurement of health outcomes. Furthermore, future RCTs should be designed to isolate the effect of the PGHD intervention from other components in a multicomponent intervention.
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McKenna, Patrick, and Mark Evans. Emergency Relief and complex service delivery: Towards better outcomes. Queensland University of Technology, June 2021. http://dx.doi.org/10.5204/rep.eprints.211133.
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Emergency Relief (ER) is a Department of Social Services (DSS) funded program, delivered by 197 community organisations (ER Providers) across Australia, to assist people facing a financial crisis with financial/material aid and referrals to other support programs. ER has been playing this important role in Australian communities since 1979. Without ER, more people living in Australia who experience a financial crisis might face further harm such as crippling debt or homelessness. The Emergency Relief National Coordination Group (NCG) was established in April 2020 at the start of the COVID-19 pandemic to advise the Minister for Families and Social Services on the implementation of ER. To inform its advice to the Minister, the NCG partnered with the Institute for Governance at the University of Canberra to conduct research to understand the issues and challenges faced by ER Providers and Service Users in local contexts across Australia. The research involved a desktop review of the existing literature on ER service provision, a large survey which all Commonwealth ER Providers were invited to participate in (and 122 responses were received), interviews with a purposive sample of 18 ER Providers, and the development of a program logic and theory of change for the Commonwealth ER program to assess progress. The surveys and interviews focussed on ER Provider perceptions of the strengths, weaknesses, future challenges, and areas of improvement for current ER provision. The trend of increasing case complexity, the effectiveness of ER service delivery models in achieving outcomes for Service Users, and the significance of volunteering in the sector were investigated. Separately, an evaluation of the performance of the NCG was conducted and a summary of the evaluation is provided as an appendix to this report. Several themes emerged from the review of the existing literature such as service delivery shortcomings in dealing with case complexity, the effectiveness of case management, and repeat requests for service. Interviews with ER workers and Service Users found that an uplift in workforce capability was required to deal with increasing case complexity, leading to recommendations for more training and service standards. Several service evaluations found that ER delivered with case management led to high Service User satisfaction, played an integral role in transforming the lives of people with complex needs, and lowered repeat requests for service. A large longitudinal quantitative study revealed that more time spent with participants substantially decreased the number of repeat requests for service; and, given that repeat requests for service can be an indicator of entrenched poverty, not accessing further services is likely to suggest improvement. The interviews identified the main strengths of ER to be the rapid response and flexible use of funds to stabilise crisis situations and connect people to other supports through strong local networks. Service Users trusted the system because of these strengths, and ER was often an access point to holistic support. There were three main weaknesses identified. First, funding contracts were too short and did not cover the full costs of the program—in particular, case management for complex cases. Second, many Service Users were dependent on ER which was inconsistent with the definition and intent of the program. Third, there was inconsistency in the level of service received by Service Users in different geographic locations. These weaknesses can be improved upon with a joined-up approach featuring co-design and collaborative governance, leading to the successful commissioning of social services. The survey confirmed that volunteers were significant for ER, making up 92% of all workers and 51% of all hours worked in respondent ER programs. Of the 122 respondents, volunteers amounted to 554 full-time equivalents, a contribution valued at $39.4 million. In total there were 8,316 volunteers working in the 122 respondent ER programs. The sector can support and upskill these volunteers (and employees in addition) by developing scalable training solutions such as online training modules, updating ER service standards, and engaging in collaborative learning arrangements where large and small ER Providers share resources. More engagement with peak bodies such as Volunteering Australia might also assist the sector to improve the focus on volunteer engagement. Integrated services achieve better outcomes for complex ER cases—97% of survey respondents either agreed or strongly agreed this was the case. The research identified the dimensions of service integration most relevant to ER Providers to be case management, referrals, the breadth of services offered internally, co-location with interrelated service providers, an established network of support, workforce capability, and Service User engagement. Providers can individually focus on increasing the level of service integration for their ER program to improve their ability to deal with complex cases, which are clearly on the rise. At the system level, a more joined-up approach can also improve service integration across Australia. The key dimensions of this finding are discussed next in more detail. Case management is key for achieving Service User outcomes for complex cases—89% of survey respondents either agreed or strongly agreed this was the case. Interviewees most frequently said they would provide more case management if they could change their service model. Case management allows for more time spent with the Service User, follow up with referral partners, and a higher level of expertise in service delivery to support complex cases. Of course, it is a costly model and not currently funded for all Service Users through ER. Where case management is not available as part of ER, it might be available through a related service that is part of a network of support. Where possible, ER Providers should facilitate access to case management for Service Users who would benefit. At a system level, ER models with a greater component of case management could be implemented as test cases. Referral systems are also key for achieving Service User outcomes, which is reflected in the ER Program Logic presented on page 31. The survey and interview data show that referrals within an integrated service (internal) or in a service hub (co-located) are most effective. Where this is not possible, warm referrals within a trusted network of support are more effective than cold referrals leading to higher take-up and beneficial Service User outcomes. However, cold referrals are most common, pointing to a weakness in ER referral systems. This is because ER Providers do not operate or co-locate with interrelated services in many cases, nor do they have the case management capacity to provide warm referrals in many other cases. For mental illness support, which interviewees identified as one of the most difficult issues to deal with, ER Providers offer an integrated service only 23% of the time, warm referrals 34% of the time, and cold referrals 43% of the time. A focus on referral systems at the individual ER Provider level, and system level through a joined-up approach, might lead to better outcomes for Service Users. The program logic and theory of change for ER have been documented with input from the research findings and included in Section 4.3 on page 31. These show that ER helps people facing a financial crisis to meet their immediate needs, avoid further harm, and access a path to recovery. The research demonstrates that ER is fundamental to supporting vulnerable people in Australia and should therefore continue to be funded by government.
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Child marriage briefing: Mozambique. Population Council, 2005. http://dx.doi.org/10.31899/pgy19.1003.
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This brief provides an overview of child marriage as well as the particulars of child marriage in Mozambique. Mozambique, in southeastern Africa, is home to 17.5 million people, with 45 percent of its population under age 15. More than three-quarters of Mozambicans live on less than US$2 a day. The HIV/AIDS epidemic has had a devastating effect on the country; approximately 1.3 million adults and children are living with HIV, and 470,000 children have been orphaned because of AIDS. Life expectancy has fallen to 34 years, among the lowest levels in the world. Mozambique has one of the most severe crises of child marriage in the world today. Several local women’s rights groups have begun speaking out about this issue and were instrumental in ensuring the passage of the recent Family Law, which raises the minimum age of marriage for girls from 14 to 18, allows women to inherit property in the case of divorce, and legally recognizes traditional marriages. However, little capacity exists to implement the law. Included in this brief are recommendations to promote later, chosen, and legal marriage.
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Child marriage briefing: Zambia. Population Council, 2005. http://dx.doi.org/10.31899/pgy19.1005.
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This brief provides an overview of child marriage as well as the particulars of child marriage in Zambia. This landlocked southern African nation is home to 10.9 million people, with 47 percent of its population under age 15. Zambia is one of the poorest countries in the world; nearly two out of three Zambians live on less than US$1 a day. The country’s economic growth was hindered by declining copper prices and a prolonged drought in the 1980s and 1990s. More recently, the AIDS epidemic has taken a devastating toll: 920,000 adults and children are living with HIV/AIDS, and 630,000 children have been orphaned because of the disease. Child marriage is widespread in Zambia, even though the legal age of marriage is 21 for both males and females. Customary law and practice discriminate against girls and women with respect to inheritance, property, and divorce rights. Domestic violence is a serious problem, with over half of married girls reporting ever experiencing physical violence and more than a third reporting abuse in the past year. Included in this brief are recommendations to promote later, chosen, and legal marriage.
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Child marriage briefing: Nigeria. Population Council, 2005. http://dx.doi.org/10.31899/pgy19.1004.
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This brief provides an overview of child marriage as well as the particulars of child marriage in Nigeria, one of the poorest countries in the world. More than two out of three Nigerians live on less than US$1 a day, and life expectancy is 52 years. The HIV/AIDS epidemic has had a devastating effect on the country, and Nigeria has some of the highest rates of early marriage worldwide. The Child Rights Act, passed in 2003, raised the minimum age of marriage to 18 for girls. However, federal law may be implemented differently at the state level, and to date only a few of the country’s 36 states have begun developing provisions to execute the law. Domestic violence is widespread and a high prevalence of child marriage exists. Nationwide, 20 percent of girls are married by age 15, and 40 percent are married by age 18. Although the practice of polygyny is decreasing, 27 percent of married girls aged 15–19 are in polygynous marriages. Included in this brief are recommendations to promote later, chosen, and legal marriage.