Relevant bibliographies by topics / One-pot reactions / Dissertations / Theses
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Dissertations / Theses on the topic 'One-pot reactions'

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Published: 4 June 2021
Last updated: 26 July 2025

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1

Anderson, Mattias. "Amine Transaminases in Multi-Step One-Pot Reactions." Doctoral thesis, KTH, Industriell bioteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-199646.

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Amine transaminases are enzymes that catalyze the mild and selective formation of primary amines, which are useful building blocks for biologically active compounds and natural products. In order to make the production of these kinds of compounds more efficient from both a practical and an environmental point of view, amine transaminases were incorporated into multi-step one-pot reactions. With this kind of methodology there is no need for isolation of intermediates, and thus unnecessary work-up steps can be omitted and formation of waste is prevented. Amine transaminases were successfully com
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2

TAMBURRINI, ALICE. "ONE-POT SYNTHESIS OF THIO-GLYCOMIMETICS THROUGH RING OPENING REACTIONS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/607912.

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Glycomimetics are compounds able to mimic structural and functional aspects of the corresponding natural carbohydrates. The main goal of using these mimetics, e.g. as therapeutic agents, is the manipulation of the chemical information encoded by sugars, controlling and altering the flow of these information. Sugars, and their mimetics, are selectively recognised by certain proteins, called lectins. An example of these lectins is DC-SIGN. DC-SIGN (Dendritic Cell-Specific ICAM-3 Grabbing Non-integrin) is a tetrameric calcium dependent (C-type) lectin expressed by dermal dendritic cells (DCs) an
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3

Ahmad, Sajjad. "One-pot tandem reactions for the stereoselective synthesis of functionalised carbocycles." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3524/.

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A one-pot, two step tandem process involving an Overman rearrangement and a ring closing metathesis reaction has been utilised for the efficient synthesis of various cyclic allylic trichloroacetamides from simple allylic alcohols. Various methods were then investigated for the allylic oxidation of a carbocyclic amide using TBHP along with different transition metals such as Pd, Se, Mn and Cr. This was required for the synthesis of the important building blocks for the construction of structurally diverse antiviral and anticancer carbocyclic nucleosides and natural products. The oxidation of (1
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4

Pelletier, Sophie Marie-Clémentine. "One-pot nitro-Mannich cascade reactions : new methodologies and synthetic applications." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:283641bf-bb4e-48a8-8a28-2e048b8c4ea6.

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Pyrrolidine and pyrrolidinone rings are common motifs found in many biologically active natural products and drugs. Accordingly, our work focuses on the development of new methodologies for their one-pot synthesis. An efficient diastereoselective nitro-Mannich / lactamisation reaction cascade of methyl 3-nitropropanoate with cyclic and acyclic imines for the direct preparation of trans-monocyclic and fused tricyclic pyrrolidinone derivatives was developed. The reaction is easy to perform, broad in scope and tolerates a wide variety of functional groups. For the monocyclic methodology, 28 examp
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5

Sapsford, Katherine. "One-pot-two-step reactions in the formation of nitrogen-containing heterocycles." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/8570/.

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6

Nassar, Hardy Luma. "Tandem reactions using multi-task catalysts." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14317/document.

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Le développement d’une chimie propre et donc durable est un des challenges majeurs du 21ème siècle dans les pays industrialisés. Étant au cœur de nombreuses découvertes dans divers domaines scientifiques allant de la physique à la médecine, les sciences chimiques doivent jouer un rôle central pour résoudre un certain nombre de problèmes environnementaux auxquels nous devons faire face. Mon travail de thèse s’inscrit dans cette problématique par le développement de méthodologies de synthèse faisant intervenir plusieurs transformations dans le même réacteur. Nous avons notamment développé des sé
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7

McGonagle, Fiona I. "The development of one-pot tandem reactions for the synthesis of polycyclic y-lactams." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3684/.

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A novel tandem process has been developed for the stereoselective synthesis of bicyclic γ-lactams. Treatment of an allylic alcohol with trichloroacetonitrile, in the presence of DBU, affords the corresponding allylic trichloroacetimidate. This is then subjected to a tandem Overman rearrangement/RCM/Kharasch cyclisation, forming the desired bicyclic lactam in high yield and high enantiomeric excess. Overall, the one-pot tandem process involves three mechanistically distinct processes catalysed by palladium(II) (step 1) and Grubbs 1st generation catalyst (steps 2 and 3). The use of a thermal Ove
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8

Loh, Chuanjie [Verfasser]. "Merging organocatalysis and transition metals in enantioselective one-pot sequential reactions and new concepts in organocatalytic domino reactions / Chuanjie Loh." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1048607143/34.

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9

Margraf, Natalie [Verfasser], Georg [Akademischer Betreuer] Manolikakes, and Joachim [Akademischer Betreuer] Engels. "Development of one-pot and multicomponent reactions towards Sulfones and Sulfonamides / Natalie Margraf. Gutachter: Georg Manolikakes ; Joachim Engels." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2015. http://d-nb.info/1077557671/34.

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10

Song, Xiaoxiao Verfasser], Dieter [Akademischer Betreuer] [Enders, and Markus [Akademischer Betreuer] Albrecht. "N-heterocyclic carbene organocatalytic transformations in one-pot sequential and domino reactions / Xiaoxiao Song ; Dieter Enders, Markus Albrecht." Aachen : Universitätsbibliothek der RWTH Aachen, 2015. http://d-nb.info/1126278416/34.

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11

Song, Xiaoxiao [Verfasser], Dieter [Akademischer Betreuer] Enders, and Markus [Akademischer Betreuer] Albrecht. "N-heterocyclic carbene organocatalytic transformations in one-pot sequential and domino reactions / Xiaoxiao Song ; Dieter Enders, Markus Albrecht." Aachen : Universitätsbibliothek der RWTH Aachen, 2015. http://d-nb.info/1126278416/34.

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12

Jasselin-Hinschberger, Adeline. "Polyfonctionnalisations sélectives par voie organométallique en série furopyridines : développement de procédés séquentiels et "one-pot" originaux." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0163/document.

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Le travail décrit dans ce mémoire concerne l'étude de la métallation régiosélective d’un bicycle fusionné: la furo[3,2-B]pyridine. L'influence de la nature du système basique sur le cours de la réaction et sur la régiosélectivité de la lithiation a été étudiée avec différentes bases : n-BuLi, LiTMP, LiDA et [n-BuLi/LiDMAE]. D'un point de vue fondamental, cette étude nous a permis d'établir quelques règles pour la fonctionnalisation des furopyidines, ce qui nous a conduit à l'obtention efficace et rapide d'une vaste chimiothèque de furo[3,2-B]pyridines polyfonctionnalisées et refonctionnalisabl
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13

Cusati, Giuseppe. "La catalyse hétérogène au palladium en chimie fine : une étude sur la synthèse " one-pot " de stilbènes et bibenzyles : application à la synthèse de styrènes et aryl-indoles." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00876267.

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Les synthèses " one pot " multi-étapes efficaces et éco-compatibles ont été envisagées pour la synthèse de molécules potentiellement bioactives tels que les systèmes bis(bibenzyliques) et leurs précurseurs stilbéniques ou bibenzyliques par catalyse hétérogène au palladium. Une synthèse " one-pot " impliquant une réaction de couplage de Heck suivie d'une hydrogénation des stilbènes ainsi formés a été mise au point en présence de Pd/C. Cette stratégie c'est révélée être limitée lors de l'application à des substrats désactivés et stériquement encombrées. Couplée au manque de disponibilité commerc
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14

Naas, Mohammed. "Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2009/document.

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L’accès à de nouveaux composés hétérocycliques originaux biologiquement actifs nécessite la mise au point de nouvelles méthodes de synthèse rapides et efficaces. Dans ce contexte, nous nous sommes intéressés à la réactivité des indazoles. Dans la première partie, nous avons étudié la sélectivité des couplages de type Suzuki, pour fonctionnaliser la position 3 d’indazoles possédant la fonction NH libre. Par la suite, un nouveau procédé d’(hétéro)arylation direct pallado-catalysé régiosélectif a été mis à profit pour synthétiser des indazoles fonctionnalisés tant sur la position 3 que sur le som
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15

Milli, Lorenzo. "Organocatalytic tandem reactions of polyfunctional compounds for the synthesis of enantioenriched heterocycles. Reazioni tandem organocatalitiche di composti polifunzionali per la sintesi di eterocicli enantioarricchiti." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3879/.

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In questo lavoro di tesi sono state sviluppate reazioni domino, tandem e procedure one-pot per ottenere eterocicli enatioarricchiti. Lo sviluppo di queste metodologie sintetiche è molto importante perché permettono di ottenere molecole complesse partendo da prodotti semplici, senza effettuare ripetuti passaggi di purificazione (stop-and-go or step-by-step synthesis). Lo scopo di questo lavoro è di ottenere derivati tetraidrofuranici modificati e derivati ossoazzolinici enantioarrichiti tramite reazioni SN2-Michael o tramite reazioni aldolica-ciclizzazione-Michael usando la catalisi asimmetrica
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16

Bassoude, Ibtissam. "Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique." Phd thesis, Université d'Orléans, 2012. http://tel.archives-ouvertes.fr/tel-00789954.

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Nos travaux de thèse portent sur la mise au point de nouvelles méthodes de synthèse permettant l'accès de façon rapide et efficace à différents dérivés pyrazolo[1,5-a]pyrimidiniques diversement fonctionnalisés.La première partie de ce travail concerne l'étude et l'application de la condensation de la pyran-2-one avec les 5(3)-amino-3(5)-arylpyrazoles que ce soit par chauffage classique ou sous irradiation micro-onde. Par la suite, un nouveau procédé d'(hétéro)arylation pallado-catalysé direct régiosélectif a été mis à profit pour élaborer des pyrazolo[1,5-a]pyrimidines fonctionnalisées tant en
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17

Vasconcelos, Stanley Nunes Siqueira. "Síntese de 5-organoteluro-1H-1,2,3-triazóis-1,4-dissubstituídos, funcionalização via reação de acoplamento cruzado de Sonogashira e síntese one-pot de derivados do indol-3-glioxila e indol-3-glioxil-1,2,3-triazóis." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-16012014-141941/.

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No capítulo 1 apresentamos uma síntese eficiente de compostos 5-organoteluro-1H- 1,2,3-triazóis realizada via reação de cicloadição [3+2] entre azidas orgânicas e alquinos substituídos com organotelúrio. Além disso, os 5-organoteluro-1H-1,2,3-triazóis foram funcionalizados na posição 5 do anel triazólico por reação de acoplamento cruzado de Sonogashira. A regioquímica dos produtos de cicloadição foram descritas com base em experimentos de RMN, cálculos teóricos e cristalografia de raio-x. Apresentamos uma proposta mecanística para a cicloadição mediada por cobre, baseada em experimentos de esp
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18

Ma, Junjun. "Synthesis and Optimization of ‘Sugar tongs’ Lock Neutraligands of the Chemokine CXCL12." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS241.

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L’Héparane Sulfate (HS) est un polysaccharide linéaire hautement sulfaté largement présent à la surface des cellules ou dans la matrice extracellulaire des tissus animaux. L’HS est l'un des polymères les plus hétérogènes et présente une alternance de domaines fortement sulfatés (S) et faiblement sulfatés (A). L'exposition à la surface cellulaire de ces domaines SAS permet d'établir des interactions spécifiques avec des protéines basiques présentant des topologies de charges complémentaires, permettant la régulation de leurs activités biologiques. CXCL12, une protéine de la famille des chimioki
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19

Pantaine, Loïc. "Aminocatalyse et Réactions en Cascade pour la Synthèse de Polycycles Tridimensionnels." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLV084/document.

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Les travaux exposés dans ce manuscrit ont pour objectif d’étudier des séquences réactionnelles organocatalysées permettant la formation stéréosélective de liaisons carbone-carbone ou carbone-hétéroatome. Plusieurs stratégies ont été développées pour la préparation d’architectures cycliques chirales dont la synthèse représente un enjeu important en raison de leur présence dans un grand nombre de molécules d’intérêt biologique. Le manuscrit débute par une introduction sur le principe de l’organocatalyse en se focalisant sur les différents modes d’activation en aminocatalyse.Le premier chapitre t
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20

Mills, M. R. "The development of a one-pot 1,4-addition/nitro-Mannich reaction." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/134188/.

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The introduction of this thesis reviews the three areas of importance to the research carried out. These are the nitro-Mannich reaction, the conjugate addition of nucleophiles to nitro-alkenes and the diastereoselectivity of electrophilic additions to substrates bearing an α-stereocentre. The Results and Discussion details the research carried out into the development of a one-pot 1,4-addition/nitro-Mannich reaction. Initially the research focused on triggering the reaction using a cyanide nucleophile. Three cyanide sources were investigated, trimethylsilylcyanide, potassium ferrous cyanide an
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21

Esgulian, Mathieu. "Oxyhomologation diastéréosélective de la sérine : développement de la méthodologie MAC." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS392/document.

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La méthodologie MAC consiste à employer des réactifs umpolung pour permettre l’insertion formelle d’une fonction carbonyle entre un électrophile et un nucléophile. Cette thèse est consacrée à l’oxyhomologation diastéréosélective de la L-sérine grâce à un développement significatif de la méthodologie MAC à trois composants en one-pot, conduisant à l’obtention de dérivés orthogonalement protégés de l’acide α, γ-dihydroxy-β-aminobutyrique. Ce dernier est une brique moléculaire acyclique à 4 atomes de carbone hautement fonctionnalisée qui est souvent intégrée dans les squelettes de molécules biolo
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22

Zhang, Xiang. "One-pot catalytic reaction of crude glycerin for biopolyols and polyurethane foam production." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306458447.

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23

Balgobin, Sinead. "Rollover in the synthesis of polycyclic indoles, and a one-pot Zipper-Click reaction." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/rollover-in-the-synthesis-of-polycyclic-indoles-and-a-onepot-zipperclick-reaction(3ae28491-c4e1-435c-aa13-66a56f82d1ab).html.

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This thesis contains two chapters, the first concerning the use of C-H activation in the synthesis of polyaromatic indoles, and the second concerning an investigation into the acetylene zipper reaction. C-H activation provides a convenient, atom efficient route for the construction of C-C bonds, without the prerequisite for stoichiometric organometallic precursors or pre-functionalisation of the substrates. In this research the use of C-H activation for the insertion of an alkyne into an N-(hetero)arylated indole system has been investigated; the transformation was achieved using Rh catalysis
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24

Schümperli, Michael. "The system of biotransformations : multi-enzyme reaction engineering for one-pot synthesis of vicinal diols /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17692.

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25

Grafton, Mark W. "New one-pot multi-reaction processes for the synthesis of highly functionalised carbocycles and heterocycles." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5864/.

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With the use of a one-pot process, a diastereoselective synthesis of bicyclononanes and decanes has been developed. Initial treatment of an allylic alcohol with trichloroacetonitrile, in the presence of DBU, afforded the corresponding allylic trichloroacetimidate. The trichloroacetimidate was then subjected to a one-pot process involving a thermal Overman rearrangement, ring-closing-enyne-metathesis and a hydrogen-bond directed Diels-Alder reaction to form polycyclic products in good isolated yields and as single diastereomers. Research was then carried out on how this process could be extende
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26

Sharif, Salaheddin Ahmad Ibrahim. "Novel one-pot multi-bond forming reaction processes for the preparation of biologically active heterocycles." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8006/.

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During the course of this PhD, a new one-pot thermal Overman rearrangement and ring-closing metathesis process was developed for the preparation of polycyclic compounds. In this method, commercially available phenols and anilines were converted to alkene derived allylic alcohols and then transformed via a one-pot process into 5-amino 2,5-dihydro-1-benzoxepines and 5-amino 2,5-dihydro-1H-benzazepines. The synthetic utility of these compounds was explored with the preparation of highly substituted hydroxylated analogues as well as a highly active hypotensive agent. A novel one-pot process was al
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27

Paris, Juraj [Verfasser]. "Combination of Suzuki cross-coupling reaction and biocatalysis in one-pot cascade processes / Juraj Paris." Bielefeld : Universitätsbibliothek Bielefeld, 2019. http://d-nb.info/1206592222/34.

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28

Giorgi, Pascal. "Nouvelles réactions à économie d'atomes et d'étapes basées sur la catalyse par des nanoparticules d'or et la multicatalyse. Applications dans la synthèse de chimie fine et des odorants." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4127.

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L'élaboration de méthodes de synthèse, basées sur l’utilisation d’espèces métalliques a été un sujet de tous les instances en chimie organique. Malgré l’efficacité des métaux utilisés en catalyse homogènes, leurs procédures de recyclage restent limitées. Ce pourquoi, une contrainte supplémentaire a été placée dans la conception de catalyseurs, pouvant offrir à la fois l'efficacité de la catalyse homogène et le recyclage de l’hétérogène. Dans ce contexte, les nanoparticules métalliques sont apparues comme objet phare, en raison de leurs propriétés physico-chimiques inégalées. On a découvert que
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Calder, Ewen D. D. "The development of one-pot multi-reaction processes for the synthesis of natural products and biologically active compounds." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6667/.

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This thesis is divided into four chapters in which one-pot processes have been developed and utilised for the synthesis of biologically active compounds. The work in the first chapter outlines the 13-step total synthesis of D -ribo- and L - arabino-phytosphingosine from D -ribose. This process employed a microwave promoted Overman rearrangement of an allylic trichloroacetimidate to install the amine functionality. In the second and third chapters, the development of a one-pot, two-step Overman/ring closing metathesis process is detailed. The synthesis of three different classes of starting mat
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30

Mayieka, Morgan Ongaga. "Attempted Azidation of Carbohydrate Secondary Alcohols Using Arylsulfonyl Azides." Youngstown State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1596709362791187.

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31

Mardjan, Muhammad Idham. "γ-hydroxybutyrolactams : preparation and synthetic applications to access polyheterocyclic and spirolactam compounds". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4378.

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Les 5-hydroxy-1H-pyrrol-2(5H)-ones ou y-hydroxybutyrolactames sont des composés synthétiques intéressants puisque ces hétérocycliques sont non seulement présents dans un grand nombre de produits naturels, mais sont aussi des briques moléculaires en synthèse organique. L'objectif principal de ce travail a été de développer un processus général et rapide pour préparer les y-hydroxybutyrolactams à partir de produits de départ facilement disponibles ou commerciaux.Ce travail a d'abord été axé sur la synthèse de y-hydroxybutyrolactames via une réaction multicomposée entre des acides (Z)-β-iodo-α,ß-
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32

Balas, Matthieu. "Sustainable catalytic process for the one-pot formation of cyclic carbonates through oxidation of alkenes and CO2 cycloaddition." Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS068.

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Ce projet a pour objectif la mise au point d’une réaction globale de synthèse de styrène carbonate à partir du styrène en présence de CO2 et d’un oxydant propre : O2. Les catalyseurs Salophen-R-M (R = Me2N, Et2N, tBu et M = Mn, Ni et Cr) ont été synthétisés et leur activité co-catalytique pour la réaction de cycloaddition de CO2 sur le styrène oxyde a été évaluée en présence de Bu4NBr ; Salophen-Me2N-Cr a présenté les meilleurs résultats : 99% de rendement obtenu après 3h à 80°C. Les complexes Salophen-R-M ont été greffés sur silice mésoporeuse {NH2}-SBA-15 par liaison covalente. En parallèle,
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33

Isleyen, Alper. "One-pot Synthesis Of Chloroalcohols And Their Lipase Mediated Kinetic Resolution - Ferrocenyl Aziridinylmethanols As Chiral Ligands In Enantioselective Conjugate Diethylzinc Addition To Enones." Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608857/index.pdf.

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An unexpected tricyclic ether formation instead of acetate addition to the double bond of a norbornene derivative aroused our interest to explore the mechanism of this reaction. Mechanistic studies showed that methylene diacetate (MDA) was formed in the stock solution (NBu4OAc + dichloromethane) and decomposed to formaldehyde under Lewis or Br&oslash<br>nsted acid conditions. Formaldehyde and olefin condensation (Prins reaction) clearly explains the formation of the unexpected product. Same methodology was then successfully applied to develop a one-step procedure for the synthesis of 3-chloro-
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34

Mardjan, Muhammad Idham. "γ-hydroxybutyrolactams : preparation and synthetic applications to access polyheterocyclic and spirolactam compounds". Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4378.

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Les 5-hydroxy-1H-pyrrol-2(5H)-ones ou y-hydroxybutyrolactames sont des composés synthétiques intéressants puisque ces hétérocycliques sont non seulement présents dans un grand nombre de produits naturels, mais sont aussi des briques moléculaires en synthèse organique. L'objectif principal de ce travail a été de développer un processus général et rapide pour préparer les y-hydroxybutyrolactams à partir de produits de départ facilement disponibles ou commerciaux.Ce travail a d'abord été axé sur la synthèse de y-hydroxybutyrolactames via une réaction multicomposée entre des acides (Z)-β-iodo-α,ß-
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35

Tay, Ming Kiong Michael. "Les carbanions alpha-phosphonylés, agents de transfert fonctionnel : applications synthétiques." Rouen, 1987. http://www.theses.fr/1987ROUES043.

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Cette étude développe les avantages de la voie carbanionique dans la préparation des phosphonates fonctionnels. La condensation des carbanions d'alkyphosphonates avec des précurseurs fonctionnels appropriés permet d'accéder aux énamines, amides et esters alpha-phosphorylés alpha-substitués. Elle permet d'introduire sur le carbone en alpha des substituants non accessibles par la synthèse traditionnelle de Michaelis-Arbusov. La stabilisation de l'intermédiaire réactionnel par complexation du cation avec le groupe phosphoryle assure sa formation facile et sa protection contre des attaques seconda
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36

Ambeu, N'ta Christelle. "Synthèse d'analogues de la pentamidine porteurs de plateformes hétérocycliques (rhodanine, benzimidazole, pyrazole et imidazole) et leurs évaluations biologiques." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1S137/document.

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Ce manuscrit de thèse concerne le développement d'une stratégie de synthèse multi-étapes de nouveaux composés comportant plusieurs plateformes hétérocycliques (rhodanine, benzimidazole, pyrazole et imidazole) à visée thérapeutique multiple contre la malaria, la leishmaniose, le cancer et les maladies neurodégénératives. Les pharmacomodulations de ces composés ont été élaborées sur la base du modèle de la pentamidine 35 comportant 2 motifs benzamidines (parties « Ouest » et « Est »). En effet, la substitution de sa partie « Ouest » par une plateforme rhodanine ou benzimidazole et de sa partie «
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Chen, Xu. "Investigation of the Phase transformation in FePtM nanoparticles (M= Ag, Cu) at atomic scale for optimized oxygen reduction catalysis." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC235.

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Les piles à combustible à membrane échangeuse de protons sont prometteuses en tant que nouveaux dispositifs de conversion d'énergie en raison de leur rendement élevé et de leur faible impact sur l'environnement. Cependant, les charges de Pt nécessaires pour compenser la mauvaise cinétique de la réaction de réduction de l'oxygène entravent leurs applications à grande échelle. Récemment, il est devenu possible d'améliorer l'activité des catalyseurs en exploitant des effets géométriques et/ou électroniques. Ainsi, les alliages binaires à base de Pt avec une structure ordonnée ont-ils montré une a
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Bielawski, Marcin. "Diaryliodonium Salts : Development of Synthetic Methodologies and α-Arylation of Enolates". Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-54738.

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This thesis describes novel reaction protocols for the synthesis of diaryliodonium salts and also provides an insight to the mechanism of α-arylation of carbonyl compounds with diaryliodonium salts.  The first chapter gives a general introduction to the field of hypervalent iodine chemistry, mainly focusing on recent developments and applications of diaryliodonium salts. Chapter two describes the synthesis of electron-rich to electron-poor diaryliodonium triflates, in moderate to excellent yields from a range of arenes and iodoarenes. In chapter three, it is described that molecular iodine can
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Genty, Axelle. "Synthèse stéréοsélective d’hétérοcycles azοtés par réactiοns mοnοtοpes dοminο". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMLH30.

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Les hétérocycles azotés sont particulièrement présents en chimie médicinale et pharmaceutique. Les δ-lactames, en particulier, connaissent un essor croissant en raison de leur fort intérêt biologique et de leur utilisation en tant qu'intermédiaires réactionnels pour la synthèse de molécules d'intérêt. L’étude croissante de ces composés conduit à une recherche de nouvelles voies de synthèse pour accéder à ces motifs polyfonctionnalisés. Les réactions monotopes se distinguent comme une stratégie privilégiée, permettant, en une seule étape, la formation de multiples liaisons et centres stéréogène
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Lorusso, Patrizia. "Metal catalysed alkylation of carbonyl compounds with formaldehyde." Thesis, University of St Andrews, 2015. http://hdl.handle.net/10023/7823.

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Formaldehyde is a chemical used widely in the manufacture of building materials. A remarkable example is represented by the Lucite two-step Alpha technology for the large scale production of methyl methacrylate (MMA), the essential building block of all acrylic-based products. Esters and ketones are important intermediates in the manufacture of acrylate esters therefore α-hydroxymethylenation of carbonyl compounds using formaldehyde as a one carbon alkylating agent and subsequent dehydration to the corresponding methylenated derivatives has been explored in the current work. We report a novel
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Mortinho, Ana Cristina da Costa. "Novel synthetic routes towards azaindoles, Exploring one-pot metal-catalysed reactions." Master's thesis, 2018. http://hdl.handle.net/10362/53594.

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Azaindoles are heterocyclic compounds scarce in nature, although interesting scaffolds in medicinal chemistry so there is a need of developing sustainable synthetic methods to obtain these cores. To date several methods involving more than one metal-catalysed reaction, like C-N cross-coupling,Heck coupling or the Sonogashira have been developed towards azaindoles. However, these methods require the use of amino-halopyridines as starting materials, which are difficult to prepare. This project aimed to surpass the need of functionalization of aminopyridines conceiving a fast and scalable one-p
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Panteleev, Jane. "Rhodium and Palladium Catalysis in the Synthesis of Carbo- and Heterocycles." Thesis, 2012. http://hdl.handle.net/1807/34831.

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This thesis describes the development of transition metal catalyzed transformations towards the synthesis of stereochemically rich motifs and heterocycles. The main themes present throughout this thesis are rhodium-catalysis in reactions of boronic acids with alkenes and alkynes, the use of alkynes as a key motif in the synthesis of heterocycles, and the use of domino and one-pot processes to effect high efficiency in multistep transformations. In Chapter 1, a rhodium-catalyzed desymmetrization of diazabicyclic alkenes with boronic acids is discussed. In this work a chemodivergent and enantio
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Lu, Kuan-Ming, and 盧冠銘. "Development of One-Pot Reactions for Dye-Sensitized and Perovskite Solar Cells via Sequential C-H Arylations." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/16278482692009439183.

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碩士<br>國立中央大學<br>化學工程與材料工程學系<br>105<br>We use 3,4-ethylenedioxythiophene (EDOT), thiophene as middle core and π-linker. In the end groups, we use different donors such as triphenylamine (TPA), carbazole with different alkyl chain to measure their electrochemical, thermal properties, hole mobility and photovoltaic performance. For applications in dye-sensitized solar cells (DSSCs) and perovskite solar cells (PSCs), we demonstrate that two D-A-π-A type new organic sensitizers (CYL-20 and CYL-21) and D-π-D-π-D type hole-transporting materials (KM01-KM07) can be step-economically synthesized by one
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Chaudhari, Prakash Dilip. "Development of One-Pot Organocatalytic Enantioselective Reactions for the Synthesis of Polysubstituted Spirocyclic Oxindole Derivatives and Spirocyclopentane Oxindoles." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/6z2y5u.

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博士<br>國立中正大學<br>化學暨生物化學研究所<br>107<br>This dissertation demonstrates our innovation in the area of asymmetric amino as well as hydrogen-bonding catalysis for the synthesis of enantioenriched polycyclic spirooxindole compounds. In the second chapter, we have discussed the novel organocatalytic quadruple organocascade Michael-Michael-Michael-aldol condensation reaction between (E)-1- methyl-3-(3-nitroallyl)indolin-2-one 34 and two molecules of α,β−unsaturated aldehydes 35 via consecutive iminium-enamine-iminium-enamine catalysis for the formation of highly functionalized polysubstituted spirooxin
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Yücel, Baris. "One-pot, Two-step Queuing Cascades Involving a Heck Coupling, π-Allylpalladium Trapping and Diels-Alder Reaction". Doctoral thesis, 2005. http://hdl.handle.net/11858/00-1735-0000-0006-B0C9-4.

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Jan, Rei-Hau, and 詹瑞豪. "Organocatalytic enantioselective cascade Michael-Michael-Wittig reactions of phosphorus ylides: one-pot synthesis of the all-cis trisubstituted cyclohexenecarboxylates via the [1+2+3] annulation." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/05857033837138680501.

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碩士<br>國立中正大學<br>化學所<br>98<br>The stereoselective synthesis of (4S,5R,6S)-ethyl 5-nitro-4,6-diphenylcyclohex-1-carboxylate has been achieved by an organocatalytic enantioselective cascade Michael-Michael-Wittig reaction of (carbethoxymethylene)triphenylphosphorane, trans-β-nitrostyrene and trans-cinnamaldehyde. The reaction conditions in the synthesis of all-cis trisubstituted cyclohexenecarboxylate derivatives have been modified to optimize the yields and stereoselectivities. Subsequently, a series of all-cis trisubstituted cyclohexenecarboxylate derivatives was synthesized.
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Lin, Zhe-Yi, and 林哲毅. "The study in cascade reactions of Csp2-Csp cross-coupling(Sonogashira-type reaction)、cyclization and Csp2-S cross-coupling(Ullmann-type reaction) for one-pot three-step synthesis of benzo[b]thiophene derivatives using a simple copper-chloride system." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/31214405631202089597.

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碩士<br>國立中興大學<br>化學系所<br>98<br>It has been known that 2,3-disubstituted benzo[b]thiophenes have been prepared in excellent yields via coupling of terminal alkynes with commercially available o-iodothioanisole in the presence of a palladium catalyst and subsequent electrophilic cyclization of the resulting o-(1-alkynyl)thioanisole derivatives. We have developed a new synthetic method that by using copper choride-mediated cascade reactions of Csp2-Csp coupling, intramolecular cyclization, and Csp2-S coupling without using palladium catalyst and any ligand for one-pot three-step syntheses of 2,3
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Lee, Jihoon. "Application of the silicon-directed annulation reactions to the total synthesis of natural products & studies directed toward the total synthesis of leiodolide A: preparation of the C13-C29 fragment." Thesis, 2013. https://hdl.handle.net/2144/14144.

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Brevisamide was isolated from the red tide dinoflagellate Karenia brevis in 2007. Key features of brevisamide include a substituted tetrahydropyran core and conjugated 3,4-dimethylhepta-2,4-dienal side chain. Total synthesis of brevisamide was highlighted by a stereoselective [4+2]-annulation of a (Z)-crotyl silane to furnish the substituted pyran core and Negishi cross-coupling to construct the conjugated dienal side chain. Successful application of the silane-based annulation methodology provided brevisamide in overall 17 steps and 6.4% overall yield from the known (Z)-crotyl silane. Isat
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Hsu, Che-Hao, and 許哲豪. "Synthesis of Benzol Pyran Fused Carbazole Derivatives through Pictet-Spengler Reaction and Synthesis of the 4-Benzylidene-3,6-di-phenylhex-2-en-5-ynal Deriva- tives via One-Pot Palladium Catalysed Sonogashira and Hydroalkynylation Cascade Reactions." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/99080233803268094885.

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碩士<br>國立臺灣師範大學<br>化學系<br>102<br>This thesis consists two parts. In which the first part of thesis describes the preparation of benzopyran fused carbazole derivatives from (2R,3R,4S)-4-(1H-indol-3-yl)-2-phenylchroman-3-amine through Pictet-Spengler reaction. A wide variety of benzopyran fused carbazole derivatives were synthesized in this process in good to moderate yields. The second part deals with the Pd catalyzed one pot Sonogashira and hydroalkynylation cascade reactions to the synthesis of the 4-benzylidene-3,6-diphenylhex-2-en-5-ynal derivatives. This is an unprecedented result whe
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Ahmad, Rasheed [Verfasser]. "Synthesis of functionalized triarylmethanes based on cyclocondensations of 1,3-Bis(silyloxy)-1,3-butadienes, one-pot synthesis of functionalized pyranones and synthesis of functionalized indoles and pyrroles based on Pd(0)-catalyzed reactions / vorgelegt von Rasheed Ahmad." 2009. http://d-nb.info/997079835/34.

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