Academic literature on the topic 'OneNote 2013'

In Lebanon, bladder cancer is the second most incident cancer among men. This study investigates a possible association between N-acetyltransferase 1 (NAT1) genotype, a drug-metabolizing enzyme coding gene, and bladder cancer in Lebanese men. A case-control study (54 cases and 105 hospital-based controls) was conducted in two major hospitals in Beirut. Cases were randomly selected from patients diagnosed in the period of 2002–2008. Controls were conveniently identified and selected from the same settings. Data was collected using interview questionnaire and blood analysis.NAT1genotypes were determined by PCR-RFLP. Statistical analysis revolved around univariate, bivariate, and multivariate logistic regression models, along with checks for effect modification. Results showedNAT1∗14Aallele, smoking, occupational exposure to combustion fumes, and prostate-related symptoms, to be risk factors for bladder cancer. The odds of carrying at least oneNAT1∗14Aallele are 7 times higher in cases compared to controls (OR=7.86, 95% CI: 1.53–40.39). A gene-environment interaction was identified forNAT1∗14Aallele with occupational exposure to combustion fumes. Among carriers ofNAT1∗14Aallele, the odds of bladder cancer dropped to 2.03 from 3.72. Our study suggestsNAT1∗14Aallele as a possible biomarker for bladder cancer. Further research is recommended to confirm this association.

The need to increase global accessibility to specimens while preserving the physical specimens by reducing their handling motivates digitisation. Digitisation of natural history collections has evolved from recording of specimens’ catalogue data to including digital images and 3D models of specimens. The sheer size of the collections requires developing high throughput digitisation workflows, as well as novel acquisition systems, image standardisation, curation, preservation, and publishing. For instance, herbarium sheet digitisation workflows (and fast digitisation stations) can digitise up to 6,000 specimens per day; operating digitisation stations in parallel can increase that capacity. However, other activities of digitisation workflows still rely on manual processes which throttle the speed with which images can be published. Image quality control and information extraction from images can benefit from greater automation. This presentation explores the advantages of applying semantic segmentation (Fig. 1) to improve and automate image quality management (IQM) and information extraction from images (IEFI) of physical specimens. Two experiments were designed to determine if IQM and IEFI activities can be improved by using segments instead of full images. The time for segmenting full images needs to be considered for both IQM and IEFI. A semantic segmentation method developed by the Natural History Museum (Durrant and Livermore 2018) adapted for segmenting herbarium sheet images (Dillen et al. 2019) can process 50 images in 12 minutes. The IQM experiments evaluated the application of three quality attributes to full images and to image segments: colourfulness (Fig. 2), contrast (Fig. 3) and sharpness (Fig. 4). Evaluating colourfulness is an alternative to colour quantization algorithms such as RMSE and Delta E (Hasler and Suesstrunk 2003, Palus 2006), the method produces a value indicating if the image degrades after processing. Contrast measures the difference in luminance or colour that makes an object distinguishable. Contrast is determined by the difference in colour and brightness of the object and other objects within the same field of view (Matkovic et al. 2005, Präkel 2010). Sharpness encompasses the concepts of resolution and acutance (Bahrami and Kot 2014, Präkel 2010). Sharpness influences specimen appearance and readability of information from labels and barcodes. Evaluating the criteria on 56 barcodes and 50 colour charts segments extracted from fifty images took 34 minutes (8 minutes for the barcodes and 26 minutes for colour charts). The evaluation on the corresponding full images took 100 minutes. The processing of individual segments and full images provided results equivalent to subjective manual quality management. The IEFI experiments compared the performance of four optical character recognition (OCR) programs applied to full images (Drinkwater et al. 2014) against individual segments. The four OCR programs evaluated were Tesseract 4.X, Tesseract 3.X, Abby FineReader Engine 12, and Microsoft OneNote 2013. The test was based on a set of 250 herbarium sheet images and 1,837 segments extracted from them. The results from the experiments show that there is an average OCR speed-up of 49% when using segmented images when compared to processing times for full images (Table 1). Similarly, there was an average increase of 13% in line correctness (information from lines is ordered and not fragmented (Fig. 5, Table 2 ). Additionally, the results are useful for comparing the four OCR programs, with Tesseract 3.x offering shortest processing time, while Tesseract 4.X achieving the highest scores for line accuracy (including hand written text recognition). The results suggest that IEFI could be improved by performing OCR using segments rather than whole images, leading to faster processing and more accurate outputs. The findings support the feasibility of further automation of digitisation workflows for natural history collections. In addition to increasing the accuracy and speed of IQM and IEFI activities, the explored approaches can be packaged and published, enabling automated quality management and information extraction to be offered as a service, taking advantage of cloud platforms and workflow engines.