To see the other types of publications on this topic, follow the link: Op.37.
Journal articles on the topic 'Op.37'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Op.37.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Blair, Deborah N., and Phyllis J. Kornguth. "37 MAMMOGRAPHIC FINDINGS OP SCLEROSING ADENOSIS." Investigative Radiology 21, no. 9 (September 1986): S10. http://dx.doi.org/10.1097/00004424-198609000-00055.
Full text
2
Sciera, Lucca, Saima Basit, Jan Wohlfahrt, Anne-Marie Nybo Andersen, and Heather Boyd. "OP 37 Familial co-aggregation of preeclampsia and cardiovascular disease." Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 9 (July 2017): 26. http://dx.doi.org/10.1016/j.preghy.2017.07.060.
Full text
3
Costamagna, G., A. Tringali, V. Pern, M. Mutignani, A. Gabbrielli, and L. Petruzziello. "37 OP Treatment of Zenker's diverticulum using a flexible endoscope." Digestive and Liver Disease 34 (June 2002): A10. http://dx.doi.org/10.1016/s1590-8658(02)90038-1.
Full text
4
Yoshikawa, Keisuke, Motoi Kuwahara, Miyuki Morikawa, Yuta Fukumoto, Masaki Yamana, Yuko Yamagishi, and Susumu Kusunoki. "Varied antibody reactivities and clinical relevance in anti-GQ1b antibody–related diseases." Neurology - Neuroimmunology Neuroinflammation 5, no. 6 (September 11, 2018): e501. http://dx.doi.org/10.1212/nxi.0000000000000501.
Full textAbstract:
ObjectiveTo investigate the relationship between antibody reactivities against glycolipid complexes and clinical features in Miller Fisher syndrome (MFS), Bickerstaff brainstem encephalitis (BBE), and Guillain-Barré syndrome with ophthalmoplegia (GBS-OP).MethodsUsing glycoarray, antibodies against 10 glycolipid antigens (GM1, GM2, GM4, GD1a, GD1b, GQ1b, galactocerebroside, lactosylceramide, GA1, and sulfatide) and 45 glycolipid complexes consisting 2 of the glycolipids were examined in the sera of 63 patients with GBS-OP, 37 patients with MFS, and 27 patients with BBE.ResultsAntibodies to antigens containing GQ1b were identified in 73% of patients with GBS-OP (46/63), 86.5% of patients with MFS (32/37), and 74.1% of patients with BBE (20/27), and GD1b-related antibodies were identified in 49.2% of patients with GBS-OP (31/63), 29.7% of patients with MFS (11/37), and 11.1% of patients with BBE (3/27). Comparing clinical features between patients with GBS-OP with and without both antibodies, the proportion of patients requiring artificial ventilation and presenting moderate or severe muscle weakness was higher in the positive group than in the negative group (p = 0.017 and p = 0.046, respectively).ConclusionsAntibodies binding to antigens containing GD1b and to those containing GQ1b may be involved in the development of limb weakness and respiratory failure in anti-GQ1b antibody–related diseases.
5
Mason, H. J., E. Waine, A. Stevenson, and H. K. Wilson. "Aging and Spontaneous Reactivation of Human Plasma Cholinesterase Activity After Inhibition by Organophosphorus Pesticides." Human & Experimental Toxicology 12, no. 6 (November 1993): 497–503. http://dx.doi.org/10.1177/096032719301200606.
Full textAbstract:
The in vitro rates of aging and spontaneous reactivation of human plasma cholinesterase (ChE) after inhibition by several organophosphorus pesticides (OPs) have been studied. After inhibition by OP the enzyme can undergo two simultaneous reactions; spontaneous reactivation to the active enzyme and 'aging' to an irreversibly inhibited form of the enzyme. The rates of these two reactions depend on the nature of the phosphoryl group of the OP bound to the active site of ChE. Most OPs registered for use in the UK have dimethoxy or diethoxy groups attached to the phosphorus atom. Reaction rate constants for aging and spontaneous reactivation are reported. Dimethoxy OPs cause half-lives of aging in human plasma ChE of approximately 6 hours and 23 hours at 37°C and 22°C respectively; for diethoxy OPs the values are 12 hours and 39 hours. Reappearance of enzyme activity, after removal of OP, reduced any inhibition by a maximum of 25% for dimethoxy OPs; this reappearance of enzyme activity occurs with a 'half-life' of 5 hours and 15 hours at 37°C and 22°C. These effects, both in vivo and ex vivo, may have relevance in developing a monitoring strategy for dimethoxy OPs using plasma ChE measurements. Inhibition by diethoxy OPs spontaneously reactivates very slowly, even at 37°C, and would not practically influence the measured inhibition. No spontaneous reactivation was detected in human plasma ChE inhibited by the methoxy-ethylamino substituted OP (propetamphos) or the methoxy-methylamino substituted OP (crufomate) during 45 hours incubation at 37°C.
6
Штром, А. А. "On Tone-Painting Elements of Music Language in Vocal Chamber Music by Nikolai Medtner." Музыкальная академия, no. 1(769) (March 29, 2020): 14–23. http://dx.doi.org/10.34690/32.
Full textAbstract:
Целью данной статьи является рассмотрение камерно-вокального творчества Н. К. Метнера с точки зрения живописности и звукоизобразительности. Автор вступает в полемику с критиками начала XX века, которые воспринимали метнеровскую музыку как бескрасочную и лишенную колорита. Опираясь на высказывания самого композитора в его книге «Муза и мода», проводя исполнительский анализ как фортепианной, так и вокальной партий романсов, автор статьи высвечивает звуковой образ метнеровского творчества с позиции звукописи: раскрывает звукоизобразительные элементы в фактуре таких романсов, как «Арион» op. 36 № 6, «Песнь ночи» op. 45 № 3; демонстрирует неистощимость композиторской фантазии в ритмической организации нотного текста в романсах «Телега жизни» op. 45 № 2 и «Священное место» op. 46 № 2, в повторяющихся ритмоформулах («Тишь на море» op. 15 № 7), в создании такта высшего порядка - сложного образования из тактов разного размера, расположенных друг за другом в определенной последовательности («Сумерки» op. 24 № 4), в реализации поэтического образа через лейтфактуру («Бессонница» ор. 37 № 1). В заключение статьи автор дает примеры тонкого использования как правой, так и левой педали, помогающих воплощать в музыке образы, связанные с колористической задачей. The aim of the paper is to consider vocal chamber music by N. Medtner in relation to picturesqueness and tone-painting. The author enters the debate with music critics of the beginning of the 20th century, who perceive Medtner’s music as lacking colours, i. e. non-coloristic. To confute this opinion the author refers to the composer’s statements given in his book “Muse and Fashion” and also undertakes the analyses of Medtner’s pieces from the standpoint of tone-painting. Such analyses allows to highlight pictorial elements in the texture of “Arion” (Op. 36 No. 6) and “Night Song” (Op. 45 No. 3) and to demonstrate the inexhaustibleness of the composer’s fantasy in rhythmic organization of “The Cart of Life” (Op. 45 No. 2) and “Sacred Place” (Op. 46 No. 2), in inventing iterative rhythmic formulas in “Calm Sea” (Op. 15 No. 7), in forming of “higher-order bar” — a complex unity of bars with different time-signatures placed one after another in definite succession (“Twilight” Op. 24 No. 4), in realization of poetical image by means of leit-texture (“Vigilance” Op. 37 No. 1). In conclusion the author gives examples of exquisite coloristic use of both pedals by Medtner.
7
Wheatley-Price, Paul, Boming Yang, Demetris Patsios, Devalben Patel, Clement Ma, Wei Xu, Natasha Leighl, et al. "Soluble Mesothelin-Related Peptide and Osteopontin As Markers of Response in Malignant Mesothelioma." Journal of Clinical Oncology 28, no. 20 (July 10, 2010): 3316–22. http://dx.doi.org/10.1200/jco.2009.26.9944.
Full textAbstract:
Purpose In malignant mesothelioma (MM), radiologic assessment of disease status is difficult. Both soluble mesothelin-related peptide (SMRP) and osteopontin (OP) have utility in distinguishing MM from benign pleural disease. We evaluated whether SMRP and OP also correlated with the disease course of MM. Patients and Methods Serial plasma samples from patients with MM were prospectively collected, and SMRP and OP levels were measured. Radiologic tests across time periods showing disease progression, stability, or shrinkage were compared with corresponding changes in SMRP/OP levels. Results From 41 patients, 165 samples were collected (range, 2 to 10; median 4). At study entry, 37 of 41 patients had measurable disease, of whom 92% (34 of 37) had elevated baseline SMRP levels; four of 41 patients had no evidence of recurrence and each had normal baseline SMRP levels. In 21 patients receiving systemic therapy, percentage change in SMRP more than 10% correlated with the radiologic assessment by a trained thoracic radiologist (P < .001), by formal Response Evaluation Criteria in Solid Tumors (RECIST; P = .008), or by modified RECIST (P < .001). All seven patients who underwent surgical resection with negative margins had elevated preoperative SMRP levels that fell to normal postoperatively. Rising SMRP was observed in all patients with radiologic disease progression. No associations were found with OP. Conclusion Percentage changes in SMRP levels, but not changes in OP levels, are a potentially useful marker of disease course. These findings should be validated prospectively for a role as an objective adjunctive measure of disease course in both clinical trials and clinical practice.
8
Veri, J. P., S. P. Pirani, and R. Claridge. "Crescentic Proximal Metatarsal Osteotomy for Moderate to Severe Hallux Valgus: A Mean 12.2 Year Follow-Up Study." Foot & Ankle International 22, no. 10 (October 2001): 817–22. http://dx.doi.org/10.1177/107110070102201007.
Full textAbstract:
The senior author's (R.C.) first 25 patients (37 feet) treated with a combination proximal crescentic osteotomy and distal soft-tissue reconstruction made up the patient cohort. All 25 patients were reviewed at a minimum of one year post-op (short-term follow-up) and 20/25 (31/37 feet) were reviewed again at a mean 12.2 years (range 11.4 to 13.0 yrs) post-op (long-term follow-up). This allowed for a comparison of short- and long-term results and led to a long-term follow-up rate of 84% (31/37 feet, mean 12.2 yrs). Clinical, radiographic and patient outcome measures were obtained and compared pre-op and at short- and long-term follow-up. The mean preoperative hallux valgus (HVA) and intermetatarsal angles (IMA) were 37° and 16° respectively. The mean HVA correction was 24° and IMA correction 10° at long-term follow-up with no tendency toward recurrence. Sesamoid position and first MTP subluxation was markedly improved postoperatively and the correction was maintained at long-term follow-up. Patients were asked about their satisfaction in terms of pain, appearance and motion. At long-term follow-up, more than 90% of patients were completely satisfied with pain and motion and greater than 80% with their appearance. Ninety-four percent of patients said they would have the operation again. The AOFAS clinical rating scale for the hallux was calculated retrospectively for pre-op and short-term follow-up and prospectively for long-term follow-up. The mean pre-op score was 37/100 (16 to 60) which significantly improved to 92/100 (67 to 100) at both follow-up periods, suggesting no evidence of decrease in outcome over time. Complications included two patients (5%) that were over-corrected into varus (one symptomatic, one asymptomatic), and four patients (11%) that were undercorrected, developing asymptomatic recurrences (>10° increase HVA) at long-term follow-up. In addition, two patients (5%) developed new transfer lesions postoperatively, likely related to technical error (one varus overcorrection, one dorsiflexion malunion). In conclusion, the long-term results, with a mean follow-up of 12.2 years, of the resection realignment procedure for moderate to severe hallux valgus are generally excellent and the complication rate is low and acceptable. Attention to detail, avoiding both undercorrection, which can lead to recurrence, and overcorrection, which can cause symptomatic varus, is essential.
9
Turan, Semra, and Deniz Günal Köroğlu. "Oxidative stability of soybean oil enriched with ethyl acetate extract of olive by-products." Turkish Journal of Agriculture - Food Science and Technology 8, no. 6 (June 26, 2020): 1373–79. http://dx.doi.org/10.24925/turjaf.v8i6.1373-1379.3382.
Full textAbstract:
In this study, oxidative stability of soybean oil (SBO) enriched with ethyl ecetate extracts of olive by-products was investigated. Total phenolic contents, phenolic profiles and antioxidant activities of olive wastewater (OMWW) and olive pomace (OP) extracts were also determined. Total phenolic contents of extracts obtained from OMWW and OP were 134.45 and 281.43 mg gallic acid equivalent (GAE)/g extract, respectively. While antioxidant activities of OMWW extracts in the linoleic acid emulsion were in the range of 85.79 % and 88.54 %, OP extracts had 83.30 % and 90.09 % at different concentrations (0.5, 1, 2 ve 3 mg/mL) after incubation at 37 °C. β-carotene bleaching activities of the extracts at 50 °C were found as 26.80-66.63% in OMWW extracts and 18.76-53.32% in OP extracts, respectively. 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities of OP extracts were higher than those of OMWW extracts and ranged from 30.6% to 87.7% in OP extracts and 16.6% to 54.1% in OMWW extracts at these concentrations. Both the antioxidant and antiradical activities of extracts significantly increased with increased concentration (p
10
Strehle, Elias, and Fred Steinmetz. "Dominating OP Returns: The Impact of Omni and Veriblock on Bitcoin." Journal of Grid Computing 18, no. 4 (December 2020): 575–92. http://dx.doi.org/10.1007/s10723-020-09537-9.
Full textAbstract:
AbstractBitcoin has always been used to store arbitrary data, particularly since Bitcoin Core developers added a dedicated method for data storage in 2014: the OP Return operator. This paper provides an in-depth analysis of all OP Return transactions published on Bitcoin between September 14, 2018, and December 31, 2019. The 32.4 million OP Return transactions (22% of all Bitcoin transactions) published during this period added 10 GB to the blockchain’s size. Almost all OP Return transactions can be attributed to one of 37 blockchain services. The two dominant services are Veriblock (58% of OP Return transactions) and Omni/Tether (40%). Veriblock transactions pay only 14% of the average transaction fee, partly because most of them are submitted during times when overall activity on Bitcoin is low. Omni transactions, on the other hand, pay more than twice the average transaction fee and therefore compete with regular Bitcoin transactions for inclusion in new blocks.
11
Son, Shannon L., Ashley E. Benson, Emily Hart Hayes, Akila Subramaniam, Erin A. S. Clark, and Brett D. Einerson. "Outpatient Cervical Ripening: A Cost-Minimization and Threshold Analysis." American Journal of Perinatology 37, no. 03 (August 20, 2019): 245–51. http://dx.doi.org/10.1055/s-0039-1694791.
Full textAbstract:
Objective To evaluate cost of outpatient (OP) versus inpatient (IP) ripening with transcervical balloons, and determine circumstances in which each strategy would be cost saving. Study Design We created a decision model comparing OP and IP balloon ripening in term (≥37 weeks) singleton pregnancies with unfavorable cervix. We performed a cost-minimization analysis and threshold analyses comparing two OP ripening strategies (broad and limited use) to IP ripening from a health system perspective. Base case estimates of probability, utilization, and cost were derived from the literature. The primary outcome was incremental cost of OP versus IP ripening from a hospital perspective. One- and two-way sensitivity analyses explored uncertainty in the model. Results Both OP ripening strategies were cost saving compared with IP ripening: incremental cost −$228.40/patient with broad use and −$73.48/patient with limited use. OP ripening was no longer cost saving if hours saved on labor and delivery (L&D) were <3.5, insertion visit cost >$714, or facility cost/hour on L&D <$61. Two-way sensitivity analyses showed that OP ripening was cost saving under the most plausible clinical circumstances. Conclusion In patients with unfavorable cervix, OP transcervical balloon ripening was cost saving under a wide range of circumstances, particularly if OP ripening can shorten time spent on L&D by 3.5 hours.
12
Plested, J. S., and D. M. Granoff. "Vaccine-Induced Opsonophagocytic Immunity to Neisseria meningitidis Group B." Clinical and Vaccine Immunology 15, no. 5 (March 19, 2008): 799–804. http://dx.doi.org/10.1128/cvi.00036-08.
Full textAbstract:
ABSTRACT The role of opsonophagocytosis (OP) in protection against meningococcal disease is controversial because patients with deficiencies in terminal complement proteins whose sera support OP but not bactericidal activity (BA) are at greatly increased risk of disease. We assayed complement-mediated BA and OP bactericidal activity in sera from 32 adults immunized with an outer membrane vesicle vaccine given alone or combined with an investigational recombinant protein, genome-derived neisserial antigen (GNA2132). The sera were heat inactivated to remove internal complement activity, and BA was measured with exogenous nonimmune human serum as a complement source. OP was measured with human polymorphonuclear cells (PMNs) and C6-depleted complement, which without PMNs did not support BA. Before immunization, 9 to 19% of sera from subjects in both vaccine groups combined had BA titers of ≥1:4, which increased to 41 to 72% after immunization (P < 0.01 against each of three test strains). The percentages of sera with OP titers of ≥1:5 were 3 to 16%, which increased to 55 to 72% (P < 0.001 for each strain). Most postimmunization BA-positive sera were OP positive, but 10 to 37% of BA-negative sera also were OP positive. Comparing the two vaccine groups, there were no significant differences in the percentages of sera with BA or OP activity except for a higher percentage of OP against one strain in postimmunization sera from subjects in the combination vaccine group (P ≤ 0.02). The data support independent roles for serum BA and OP bactericidal activity in protection against group B disease.
13
König, Romy. "Halb Arzt, halb Schwester." kma - Klinik Management aktuell 15, no. 12 (December 2010): 62–65. http://dx.doi.org/10.1055/s-0036-1575843.
Full textAbstract:
Sie assistieren während der OP, übernehmen körperliche Untersuchungen und kleine Eingriffe: die Physician Assistants (PA). Bisher sind 37 Absolventen in die Praxis entlassen worden. Hunderte werden noch folgen. Neben der Steinbeis-Hochschule ibt es in Kürze zwei weitere Anbieter.
14
Van Der Wel, Frans. "Verplichting tot voorziening." Maandblad Voor Accountancy en Bedrijfseconomie 76, no. 10 (October 1, 2002): 447–54. http://dx.doi.org/10.5117/mab.76.11770.
Full textAbstract:
Voor de jaarverslaggeving 2001 is de nieuwe Richtlijn 252 van kracht geworden; deze is gebaseerd op IAS 37. Door de nieuwe Richtlijn worden stringentere eisen gesteld aan de vorming van voorzieningen. Uit een beperkt praktijkonderzoek blijken nog geen grote effecten van de nieuwe Richtlijn. Stilgestaan wordt bij de verhouding tussen bijzondere waardeverminderingen van vaste activa en voorzieningen. Van een aantal specifieke voorzieningen worden toepassingskwesties behandeld. Mede gebaseerd op deze kwesties wordt ten slotte een beschouwing gewijd aan het verminderde belang van het matching- beginsel en het voorzichtigheidsbeginsel als gevolg van de nieuwe Richtlijn inzake voorzieningen.
15
Thissen, Paul. "Wort-Ton-Kunstwerk im Sinne Richard Wagners?" Die Musikforschung 69, no. 1 (September 22, 2021): 14–24. http://dx.doi.org/10.52412/mf.2016.h1.407.
Full textAbstract:
Das Lied bildet den Ausgangspunkt in Pfitzners Schaffen und ist zugleich die Gattung, die in seinem Œvre einen üeraus prominenten Platz einnimmt. Wahrend die Lieder wiederholt Gegenstand von Untersuchungen waren,standen die Orchestergesäge im AlIgemeinen - im Gegensatz zu den entsprechenden Werken Mahlers, Strauss', Schöbergs sowie Schoecks - und "Lethe" im Besonderen bisher kaum im Blickpunkt des wissenschaftlichen Interesses. Pfitzner bedachte das Orchesterlied, von Bearbeitungen abgesehen,mit fünf Werken: "Herr Oluf" op. 12 (1891), das mit zum Beginn der Gattungsgeschichte gehört (1897 entstanden Strauss' "Vier Gesänge" und 1899 "Zwei größere Gesänge"), Heinzelmännchen op. 14 (1902/03), "Zwei deutsche Gesänge" op. 25 (1916) sowie schließlich "Lethe" op. 37 (1926), womit er nach zehnjähriger Unterbrechung nochmals zum Orchesterlied zurückkehrte und, obwohl die Blütezeit der Gattung eher als vergangen angesehen werden muss, ein, wie der Autor zu zeigen versuchen möchte, im Vergleich zu seinen früheren Beiträgen gattungsgeschichtlich herausragendes Werk vorlegte, das den "Vier Letzten Liedern" (1948) von Richard Strauss zumindest im Hinblick auf den ästhetischen Anspruch durchaus nicht nachsteht.
bms online
16
Synofzik, Thomas. "Rückert-Kanon als Keimzelle zu Schumanns Klavierkonzert Op. 54." Die Musikforschung 58, no. 1 (September 22, 2021): 28–32. http://dx.doi.org/10.52412/mf.2005.h1.605.
Full textAbstract:
Im Januar 1841 komponierte Robert Schumann ein bisher unbeachtetes kanonisches Duett für seinen Rückert-Zyklus op. 37 <Ich bin dein Baum, o Gärtner>, das keine Parallelen zur späteren Vertonung op. 101/3 aufweist. Es wurde schließlich nicht in den gedruckten Zyklus übernommen, da daraus im Mai 1841 der erste Satz von Schumanns Klavierkonzert op. 54 entstand. Das Duett wurde wenig verändert als As-Dur-Mittelteil übernommen, darum herum bildet Schumann nach einer schon 1836 geäußerten Idee einen a-Moll-Konzertsatz, der eine Synthese aus dreisätzigem Konzertmodell und Sonatenhauptsatz bildet. Dessen monothematische Anlage hat ihren Ursprung somit nicht im Hauptthema, sondern im As-Dur-Mittelteil. Durch die vokale Prägung dieses Teils erscheint dessen gängige Aufführungspraxis in einem Tempo weit unterhalb der Metronomvorschrift mit oft falschen Betonungen als verfehlt.
17
Scholten, Han, and Dick van Offeren. "Juridische geschillen in de jaarrekening van beursgenoteerde ondernemingen in Nederland." Maandblad Voor Accountancy en Bedrijfseconomie 92, no. 9/10 (November 2, 2018): 231–42. http://dx.doi.org/10.5117/mab.92.28827.
Full textAbstract:
Ondernemingen worden regelmatig geconfronteerd met onzekerheden in verband met juridische geschillen. De ondernemer moet daarbij keuzes maken over het al dan niet opnemen van een voorziening in de jaarrekening, over de waardering van de voorziening en over de toelichting van de onzekerheden. Om winststuring tegen te gaan en gebruikers van relevante en betrouwbare informatie te voorzien zijn in IAS 37Provisions, Contingent Liabilities and Contingent Assetsgedetailleerde regels opgenomen voor de verslaglegging bij onzekere juridische geschillen. Hierbij maakt IAS 37 gebruik van een waarschijnlijkheidsdrempel. De schatting van de kans op uitstroom van middelen bepaalt daarmee de verwerking en waardering in de jaarrekening en de vereiste informatieverstrekking. Onderzocht is hoe de verslagleggingspraktijk omgaat met IAS 37 door de jaarrekeningen 2016 te onderzoeken van ondernemingen waarvan de aandelen zijn genoteerd aan de AEX, AMX en AScX van de Euronext Amsterdam. Op basis van de uitkomsten van het onderzoek worden aanbevelingen gedaan om tot meer relevante informatie in verband met juridische geschillen te komen.
18
Guevara-Escobar, A., A. D. Mackay, J. Hodgson, and P. D. Kemp. "Soil properties of a widely spaced, planted poplar (Populus deltoides)pasture system in a hill environment." Soil Research 40, no. 5 (2002): 873. http://dx.doi.org/10.1071/sr01080.
Full textAbstract:
Planting poplars is an effective technology for controlling hill soil erosion in New Zealand pastureland. However, the effects of widely spaced poplars on soil properties are not documented. Soil was sampled from 3 soil depths (0-75, 75-150, and 150-300 mm) in poplar-pasture (PP) and adjacent open pasture (OP) systems. Four sites were examined, 3 unreplicated sites with mature poplars (>29 years, 37-40 stems/ha) and a replicated experiment with immature poplars (5 years, 50-100 stems/ha). Pastures at all sites were dominated by low fertility species and were grazed by sheep and cattle. Pasture species were used in a glasshouse experiment to assess the production potential of the topsoil media (0-20 mm) from the PP and OP soils, and the OP topsoil amended with 5% poplar leaf litter.
19
Patsalides, Athos, Cristiano Oliveira, Jessica Wilcox, Kenroy Brown, Kartikey Grover, Yves Pierre Gobin, and Marc J. Dinkin. "Venous sinus stenting lowers the intracranial pressure in patients with idiopathic intracranial hypertension." Journal of NeuroInterventional Surgery 11, no. 2 (June 5, 2018): 175–78. http://dx.doi.org/10.1136/neurintsurg-2018-014032.
Full textAbstract:
AimsWe report the cerebrospinal fluid opening pressure (CSF-OP) measurements obtained before and after venous sinus stenting (VSS) in 50 patients with idiopathic intracranial hypertension.MethodsThe CSF-OP was measured with a spinal tap 3 months before and 3 months after treatment. All data were prospectively collected and included patient demographics, weight (kg), body mass index (BMI), acetazolamide daily dosage (mg), procedural details, complications, venous sinus pressures (mm Hg), trans-stenotic pressure gradient (mm Hg), transverse sinus symmetry, and type of venous sinus stenosis.ResultsThe average pretreatment CSF-OP was 37 cm H2O (range 25–77) and the average post-treatment CSF-OP was 20.2 cm H2O (range 10–36), with an average reduction of 16.8 cm H2O (P<0.01). The post-treatment CSF-OP was less than 25 cm H2O in 40/50 patients. The average acetazolamide daily dose decreased from 950 mg to 300 mg at the time of 3-month follow-up (P<0.01). No patient required an increase in acetazolamide dose 3 months after VSS. The average weight before treatment was 95.4 kg with an average BMI of 35.41. There was an average increase in body weight of 1.1 kg at the 3-month follow-up with an average increase in BMI of 0.35 (P=0.03).ConclusionsWe provide evidence that there is a significant decrease in CSF-OP in patients with idiopathic intracranial hypertension 3 months after VSS, independent of acetazolamide usage or weight loss.
20
Hoogendoorn, Martin, Haris Kadric, and Frans van der Wel. "Voorzieningen in de jaarrekening." Maandblad Voor Accountancy en Bedrijfseconomie 90, no. 12 (December 15, 2016): 524–23. http://dx.doi.org/10.5117/mab.90.31223.
Full textAbstract:
In de jaarrekeningen van de grootste Europese ondernemingen zijn voorzieningen een belangrijke post. Naast de in het verleden ook veelvuldig voorkomende reorganisatievoorzieningen zien we ‘nieuwe’ voorzieningen verschijnen, die vooral te maken hebben met aansprakelijkheid, ontmanteling en herstel, en milieu. De mutaties in de voorzieningen hebben soms een belangrijke invloed op het resultaat. Niet altijd voldoet de informatieverschaffing aan de eisen die IAS 37 stelt, in het bijzonder niet op het punt van de vermelding van de looptijd. Ook verbeteringen zijn mogelijk rondom de vermelding van onzekerheden betreffende de omvang of timing van voorzieningen. Voorts lijken ons de disconteringsvoeten soms te hoog, hetgeen tot een te lage waardering van de voorziening kan leiden.
21
Marguet, Christophe, Véronique Houdouin, Isabelle Pin, Philippe Reix, Frédéric Huet, Marie Mittaine, Sophie Ramel, et al. "Chest physiotherapy enhances detection of Pseudomonas aeruginosa in nonexpectorating children with cystic fibrosis." ERJ Open Research 7, no. 1 (January 2021): 00513–2020. http://dx.doi.org/10.1183/23120541.00513-2020.
Full textAbstract:
Lung damage in cystic fibrosis (CF) is strongly associated with lower airway infections. Early treatment of Pseudomonas aeruginosa is recommended. Pathogen detection requires sampling of lower airway secretions, which remains a challenge in nonexpectorating patients. Our hypothesis was that chest physiotherapy would improve the quality of airway secretion samples and increase the rates of pathogens detected in nonexpectorating patients.This prospective multicentre study compared three successive methods for sampling airway secretions applied through the same session: 1) an oropharyngeal swab (OP), 2) a chest physiotherapy session followed by a provoked cough to obtain sputum (CP-SP) and 3) a second oropharyngeal swab collected after chest physiotherapy (CP-OP). Haemophilus influenzae, Staphylococcus aureus and P. aeruginosa growth cultures were assessed. Accuracy tests and an equivalence test were performed to compare the three successive methods of collection.300 nonexpectorating children with CF were included. P. aeruginosa was detected cumulatively in 56 (18.9%) children, and according to the different collection methods in 28 (9.8%), 37 (12.4%) and 44 (14.7%) children by using OP, CP-OP and CP-SP, respectively. Compared with OP, the increased detection rate was +22% for CP-OP (p=0.029) and +57% for CP-SP (p=0.003). CP-SP had the best positive predictive value (86.3%) and negative predictive value (96.0%) for P. aeruginosa compared with the overall detection.The results of this adequately powered study show differences in the rates of pathogens detected according to the sampling method used. Chest physiotherapy enhanced detection of P. aeruginosa in nonexpectorating children with CF.
22
Ardhaoui, M., M. Brahem, S. Arfa, H. Hachfi, B. Ben Rejeb, M. Hassayoun, R. Sarraj, et al. "AB0339 PREVALENCE AND ASSOCIATED FACTORS OF LOW BONE MINERAL DENSITY IN ADULTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1194.2–1195. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3717.
Full textAbstract:
Background:Patients with Systemic Lupus Erythematosus (SLE) are at risk of osteoporosis (OP) and fragility fractures (FFx) because of the disease or its treatments. We assessed the prevalence and risk factors for OP in patients with SLE.Objectives:Our objective is to determine the prevalence of bone mineral density (BMD) loss and fracture risk factors in SLE patients undergoing dual-energy X-ray absorptiometry (DXA).Methods:This is a cross sectional study conducted during the year 2020 in the Rheumatology and internal medicine departements in Taher Sfar hospital of Mahdia, Tunisia. We included patients aged ≥18 years with a diagnosis of SLE according to the 1997 ACR or 2012 SLICC criteria. Patients with renal or hepatic osteodystrophy, or receiving bisphosphonates were excluded from the study. The BMD values were measured by DXA. The T-score, Z-scores and BMD of the lumbar spine (LS) and femoral neck (FN) were determined. OP was defined as a value of the T-score less or equal to -2.5 SD for postmenopausal women and men aged more than 50 years old, and Z-scores less or equal to -2 for premenopausal women and men aged less than 50 years old.Results:Forty-six SLE patients were included. The mean age was 47.19±16.45 years [18-85], with a mean disease duration of 2.52±3.46 years [15days-15years]. The mean SLEDAI score was 5.34±4.82. As regards menstrual history of female patients: 56.5% were premenopausal, 43.5% were post-menopausal and 6% had premature menopause. 13% of our patients gave history of smoking. The mean BMI was 27.6 ± 6 kg/m2 [15-39.8]. FFx were diagnosed in 4 patients (9%) and the mean age of the first fracture was 45years. GCs were used in 65.2% of cases (30 patients). The mean daily dose of GCs was 10 mg/day and the mean cumulative dose was 20g. Calcium and Vitamin D intake was mentioned in 65.2% of cases (30 patients). The association of SLE with other rheumatic diseases was found in 14 of patients. The mean T-score at FN and LS were respectively 0.02±1.17 and -1.32±1.36. The mean Z-score at FN and LS were respectively 0.53±1.14 and -0.6±1.26. It was found that 17 patients (37% of cases) had OP, 12 had osteopenia (26%) and 17 patients (37%) had normal BMD. 37% of patients had OP at LS, 23.9% osteopenia at LS, 6.5% OP at FN and 21.7% osteopenia at FN. Low BMD was significantly correlated with increased age (p=0.01) and disease duration(p=0.05),post-menopausal status(p=0.04), higher BMI (p=0.004), musculoskeletal involvement (p=0.01), association to other rheumatic diseases (p=0.01), higher disease activity by SLEDAI score (p=0.05), higher Erythrocyte sedimentation Rate (p=0.01) and C-Reactive Protein (p=0.007), low serum complement C3 (p=0.009) and C4 (p=0.04) and cumulative doses of GCs (p=0.01).We found also that BMD at LS was mostly affected by GCs intake, BMI and CRP while BMD at FN was mostly affected by SLEDAI score, C3 and C4 (p<0.001 in all cases). Gender, history of smoking and cardiovascular comorbidities had no significant impact on BMD.Conclusion:OP is a common but unrecognised complication of SLE with increased frequency of both peripheral and vertebral FFx. Our study suggests a high risk profile for OP and FFx in SLE which seems to be associated with age, disease duration, post-menopausal status, BMI and GCs.References:[1]Dey, M., & Bukhari, M. (2018). Predictors of fracture risk in patients with systemic lupus erythematosus. Lupus, 27(9), 1547–1551.Disclosure of Interests:None declared
23
Rudat, V., S. Streller, and D. Rades. "Treatment of cancer of the anal canal. The Hamburg experience." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 14062. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14062.
Full textAbstract:
14062 Background: To compare surgical and non-surgical treatment approaches for anal cancer and to identify prognostic factors. Methods: Survival data of 214 patients with cancer of the anal canal were reviewed who were referred for radiotherapy to the Department of Radiation Oncology of the University of Hamburg, Germany between 1/88 and 3/05. 75 patients received a definitive radiochemotherapy (RCT) with 5-FU and MMC according to international standards, 43 an operation followed by RCT (OP+RCT), 37 an operation followed by irradiation (OP+RT), 25 an irradiation alone (RT) and 34 an operation alone because they refused a planned adjuvant RCT or RT. The operations had been performed by different referring hospitals in and around Hamburg. Results: The median follow-up time of the living patients was 67 months (1–200 months). The 10 year overall survival rate for RCT was 0.62 (95%CI 0.46–0.77), for OP+RCT 0.65 (95%CI 0.47–0.83), for OP+RT 0.55 (95%CI 0.37–0.74), for OP alone 0.51 (95%CI 0.26–0.75) and for RT alone 0.27 (95%CI 0.05–0.48). There was no statistical difference between the overall survival of patients who received RCT, OP+RCT and OP+RT according to Kaplan Meier analysis (log rank test, p = 0.71). Cox regression analysis was used to examine the simultaneous influence of the prognostic factors T, N, age, haemoglobin concentration before radiotherapy, gender, and grading on the survival of patients who were treated with RCT. The model (p = 0.015) revealed T and N to be the only statistically significant prognostic factors. Conclusions: The different surgical and non-surgical approaches to treat cancer of the anal canal in Hamburg obviously reflect the individual preferences of the different physicians. Statistical analysis did not show a benefit of an OP added to RCT. Prognostic factors for survival after RCT were the T- and N-stage. No significant financial relationships to disclose.
24
Lee, Sang-Woong, Tsuyoshi Etoh, Tetsuji Ohyama, Noriyuki Inaki, Shinichi Sakuramoto, Kazuhiro Yoshida, Keisuke Koeda, et al. "Short-term outcomes from a multi-institutional, phase III study of laparoscopic versus open distal gastrectomy with D2 lymph node dissection for locally advanced gastric cancer (JLSSG0901)." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 4029. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.4029.
Full textAbstract:
4029 Background: The safety of laparoscopic gastrectomy for advanced gastric cancer is controversial. We conducted a multi-institutional, randomized controlled trial to compare short- and long-term outcomes of laparoscopic distal gastrectomy (LAP) with D2 lymph node dissection for advanced gastric cancer in comparison to open distal gastrectomy (OP) in Japan (UMIN000003420). We herein demonstrate short-term outcomes of this trial. Methods: Patients with potentially curable gastric cancer (T2-T4, N0-2 and M0) by distal gastrectomy were eligible for inclusion. Between November 2009 and July 2016, 507 patients were randomly assigned to either the LAP group (n = 252) or the OP group (n = 255). Only credentialed surgeons in both the procedures from 37 Japanese institutions participated in the study. The primary endpoint was 5-year relapse free survival. Secondary endpoints were 5-year overall survival, adverse events and short-term clinical outcomes. Results: According to study protocol, 47 patients among the total eligible patients were excluded because of distant metastasis or tumor extension intraoperatively. The remaining 460 patients underwent distal gastrectomy with D2 lymph node dissection and were analyzed as per protocol. Estimated blood loss was lower in LAP than in OP (30 vs. 150 ml, P < 0.001) and operative time was longer in LAP than in OP (291 vs. 205 min, P < 0.001). Post-operative analgesics use was less in LAP than in OP (38.3 vs. 53.6 %, P = 0.001), and first day of flatus was shorter in LAP than in OP (2 vs. 3 days, P < 0.001). There were no significant differences in all grade intra-operative complications (LAP 0.9% vs. OP 2.6%, P = 0.285). In addition, there were no significant differences in grade 3 and higher post-operative complications between the two groups (LAP 3.1% vs. OP 4.7%, P = 0.473). Hospital mortality was 0.4 % in each group. Conclusions: Credentialed surgeons could safely perform laparoscopic distal gastrectomy with D2 lymph node dissection for locally advanced gastric cancer. The laparoscopic approach could be accepted without increasing major surgical complications in this setting. Clinical trial information: 000003420.
25
Greally, Megan, Vivian E. Strong, Sam S. Yoon, Daniel G. Coit, Joanne F. Chou, Marinela Capanu, David Paul Kelsen, Yelena Yuriy Janjigian, David H. Ilson, and Geoffrey Yuyat Ku. "Total neoadjuvant chemo (ctx; TNT) for locally advanced gastric cancer (GC): The Memorial Sloan Kettering Cancer Center experience." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 4046. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.4046.
Full textAbstract:
4046 Background: Peri-op chemo (ctx) and surgery is a standard in the treatment of GC, based on the MAGIC (NEJM 2006; 355:11) and FLOT4 (J Clin Oncol 35:4004 [abstr]) studies. However, less than half of patients (pts) completed ctx in the MAGIC and FLOT4 studies, mainly from issues delivering post-op therapy. We assessed safety and feasibility of TNT, where all ctx is given pre-op. Methods: We reviewed GC pts who received TNT or peri-op ctx and had surgery; decision for TNT was by physician preference, based on clinical or radiographic benefit to justify completing ctx pre-op. Pt characteristics were compared using Fisher’s exact and Wilcoxon Rank Sum tests. Post-op length of stay (LOS) was calculated from date of surgery (DOS) to date of discharge and surgical morbidity was determined using the Clavien-Dindo classification. Progression free survival (PFS) and overall survival (OS) were calculated from DOS using Kaplan-Meier methods and compared between groups using the log-rank test. Results: 120 pts were identified, median age 63, 62.5% male, 98% ECOG 0/1. 93 pts (77.5%) received peri-op ctx and 27 (22.5%) received TNT. In peri-op pts, 19%, 43% and 38% received FLOT, platinum/fluropyrimidine (FP) and ECF/EOX respectively. In TNT pts, 56%, 37% and 7% received FLOT, platinum/FP and ECF/EOX respectively. 57% had subtotal gastrectomy. Surgical outcomes were similar between groups; median LOS was 6 and 7 days (p = 0.31) in peri-op and TNT pts respectively. There was no significant difference in Clavien Dindo grade I-II or III-IV morbidity between groups (p = 0.103). There were no deaths. TNT pts received higher proportions of planned treatment than peri-op ctx pts: 90% vs. 60% FP (0.001); 85% vs. 41% platinum ( < 0.001); 100% vs. 9% epirubicin (0.015) and 53% vs. 28% docetaxel (p = 0.169). At median follow-up of 19 months, median PFS and OS were not reached. There was no significant difference in PFS (p = 0.089) or OS (p = 0.59) between groups. Conclusions: TNT appears safe with no increase in post-op LOS or surgical morbidity observed. TNT pts had higher percentage drug delivery, suggesting potential benefit for administering all ctx before surgery. While longer survival follow-up is required, TNT may be considered in pts with locally advanced GC who are candidates for ctx.
26
Claxton, David F., Thomas J. Myers, Harry P. Erba, Stefan Faderl, M. Arellano, Roger M. Lyons, Tibor J. Kovacsovics, Janice Gabrilove, Clay R. Warnock, and Hagop M. Kantarjian. "Outpatient Treatment with Clofarabine in a Phase II Study of Older Adult Patients with Previously Untreated Acute Myelogenous Leukemia (AML)." Blood 114, no. 22 (November 20, 2009): 4162. http://dx.doi.org/10.1182/blood.v114.22.4162.4162.
Full textAbstract:
Abstract Abstract 4162 Introduction The CLASSIC II trial previously reported an overall remission rate of 46% (38% complete remission [CR] and 8% CR with incomplete platelet recovery [CRp]), median duration of remission 56 weeks, median disease-free survival 37 weeks, median overall survival 41 weeks, and 30- and 60-day mortality rates 10% and 16%, respectively (JCO 2009; 27:371s, A.7062). Among the patients achieving remission, 75% achieved a CR or CRp after the first induction cycle and 25% after the re-induction cycle. This trial allowed physicians the discretion to treat patients with inpatient (IP) or outpatient (OP) clofarabine (CLO). This report describes the experience with OP CLO treatment. Methods CLASSIC II was a single arm, Phase II study of patients ≥ 60 years of age with untreated AML with at least one unfavorable baseline prognostic factor (PF): age ≥70 years, ECOG performance status 2, antecedent hematological disorder (AHD), and/or intermediate/unfavorable risk karyotype. CLO was administered days 1-5 at 30 mg/m2 IV over 1hour during induction and at 20 mg/m2 during re-induction/consolidation for a maximum of 6 cycles. Patients with confirmed AML who received one dose of CLO were eligible for analysis. Results 112 patients (median age 71 years) received a median of 2 cycles of CLO. Thirty-five (31%) patients received OP CLO for a total of 72 outpatient cycles (Table). This report will focus only on OP CLO in cycles 2-6, since only 2 patients received OP CLO in cycle 1. 66 patients initiated a second cycle of clofarabine (38 as re-induction; 28 as consolidation). 33/66 (50%) patients received at least 1 OP cycle of CLO for a total of 70 OP cycles (57% of all cycles 2-6). 12/33 received at least 2 OP cycles of CLO. Patients received a median of 1 OP cycle (range 1-5). All 70 OP cycles were administered for 5 OP days except for 2 cycles given for 2 OP days followed by 3 IP days (associated with OP toxicities: Grade 3 rash in 1 patient and increasing transaminase levels in 1 patient). For the 70 OP cycles, 42 (60%) cycles did not require any subsequent hospitalization, while 28 (40%) cycles required hospitalization. Baseline patient and disease characteristics and treatment toxicities for patients receiving OP versus IP CLO and the reasons for hospitalization after OP CLO will be presented at the meeting. Conclusions Outpatient clofarabine can be safely administered to older patients with previously untreated AML and at least one unfavorable prognostic factor. OP CLO was primarily used for cycles 2-6, including both cycle 2 re-induction and consolidation. 60% of OP CLO cycles never required hospitalization. Proper patient selection, education, and monitoring for adverse events after OP CLO are necessary. OP CLO offers patients a more convenient option for treatment of their AML. Disclosures: Claxton: Genzyme: Research Funding. Myers:Genzyme: Employment. Erba:Lilly: Research Funding; Antisoma: Research Funding; Wyeth: Research Funding; Cephalon: Honoraria, Research Funding; MGI Pharma: Honoraria; Pharmion: Honoraria; Celgene: Honoraria; BMS: Honoraria; Novartis: Honoraria, Research Funding; Genzyme: Consultancy, Honoraria, Research Funding; Gemin-X: Research Funding; Kanisa: Research Funding. Faderl:Genzyme: Research Funding. Arellano:Genzyme: Research Funding. Lyons:Celgene: Consultancy; Johnson&Johnson: Consultancy, Honoraria, Speakers Bureau; GlaxoSmithKline: Consultancy, Speakers Bureau; Amgen Inc.: Consultancy, Honoraria, Research Funding, Speakers Bureau; Genzyme: Research Funding. Kovacsovics:Genzyme: Research Funding. Gabrilove:Genzyme: Research Funding. Warnock:Genzyme: Employment. Kantarjian:Genzyme: Research Funding.
27
Qian, Carolyn L., Helen P. Knight, Cristina R. Ferrone, Hiroko Kunitake, Carlos Fernandez-del Castillo, Michael Lanuti, Motaz Qadan, et al. "Randomized trial of a perioperative geriatric intervention for older adults with cancer." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 12012. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.12012.
Full textAbstract:
12012 Background: Older adults with gastrointestinal (GI) cancers undergoing surgery often experience poor outcomes, such as prolonged postoperative (post-op) length of stay (LOS), intensive care unit (ICU) use, and readmissions. Involvement of geriatricians in the care of older adults with cancer can improve outcomes. We conducted a randomized trial of a perioperative geriatric intervention in older adults with GI cancers undergoing surgery. Methods: We randomly assigned patients age ≥65 with GI cancers planning to undergo surgical resection to receive a perioperative geriatric intervention or usual care. Intervention patients met with a geriatrician preoperatively in the outpatient setting and post-op as an inpatient consultant. The geriatrician conducted a geriatric assessment and made recommendations to the surgical/oncology teams. The primary end point was post-op LOS. Secondary end points included post-op ICU use, readmission risk, and patient-reported symptom burden (Edmonton Symptom Assessment System [ESAS]) and depression symptoms (Geriatric Depression Scale). We conducted both intention-to-treat (ITT) and per protocol (PP) analyses. Results: From 9/13/16-4/30/19, we randomized 160 patients (72.4% enrollment rate; median age = 72 [65-92]). The ITT analyses included 137/160 patients who underwent surgery (usual care = 68/78, intervention = 69/82). The PP analyses included the 68 usual care patients and the 30/69 intervention patients who received both pre- and post-op intervention components. In ITT analyses, we found no significant differences between intervention and usual care in post-op LOS (7.2 v 8.2 days, P = .37), ICU use (23.3% v 32.4%, p = .23), and readmission rates within 90 days of surgery (21.7% v 25.0%, p = .65). Intervention patients reported lower depression symptoms (B = -1.39, P < .01) at post-op day 5 and fewer moderate/severe ESAS symptoms at post-op day 60 (B = -1.09, P = .02). In PP analyses, intervention patients had significantly shorter post-op LOS (5.9 v 8.2 days, P = .02) and lower rates of post-op ICU use (13.3% v 32.4%, p < .05), but readmission rates were not significantly different (16.7% v 25.0%, p = .36). Conclusions: Although this perioperative geriatric intervention did not have a significant impact on the primary end point in ITT analysis, we found encouraging results in several secondary outcomes and for the subgroup of patients who received the planned intervention. Future studies of this perioperative geriatric intervention should include efforts, such as telehealth visits, to ensure the intervention is delivered as planned. Clinical trial information: NCT02810652 .
28
Tealab, Safy Hosny, Nevine F. H. Sedhom, Ashraf Hassouna, Iman Gouda, and Hoda Ismail. "Prevalence of human papilloma virus in oropharyngeal, tongue and lip squamous cell carcinoma: an experience from the Egyptian National Cancer Institute." Journal of Investigative Medicine 67, no. 7 (March 13, 2019): 1061–66. http://dx.doi.org/10.1136/jim-2018-000968.
Full textAbstract:
Human papilloma virus (HPV) is now a well-known risk factor for head and neck cancer besides smoking and alcohol. Most studies mentioned that patients affected with high-risk HPV cancers have a better outcome, and many clinical trials are trying to prove that such group of patients can receive a different and less aggressive treatment than the HPV-negative group. Although such field has received great interest within different countries and continents, African and Egyptian populations are not yet well studied within the literature. Our aim was to detect the prevalence of HPV in oropharyngeal (OP), lip and tongue squamous cell carcinoma (SSC) and correlate the viral prevalence with different clinicopathologic parameters as well as patients’ outcome. HPV detection was done on 99 cases from the lip (29), tongue (38) and oropharynx (32) diagnosed at the Pathology Department of the National Cancer Institute, Cairo University. p16 immunohistochemistry was performed on all cases, followed by HPV DNA in situ hybridization (ISH) for p16-positive cases. The prevalence of HPV in OPSSC was 28% and in lip and tongue cancers lumped together was 37%. There was more than 90% concordance between p16 and HPV DNA ISH results. HPV positivity showed a statistically significant correlation with better disease-free survival (DFS), which was also maintained for OP cases. HPV is highly prevalent in OP and common oral cavity cancers in the Egyptian population. HPV positivity correlated significantly with better DFS, especially in OP cancers.
29
Sebastian, Gisi, Seetesh Ghose, and P. Soundararajan. "Comparison of maternal and neonatal outcome in elective lower segment cesarean section done at 38 and 39 weeks." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 4 (March 30, 2017): 1604. http://dx.doi.org/10.18203/2320-1770.ijrcog20171436.
Full textAbstract:
Background: Time to perform elective LSCS is a relevant issue related to mother and foetus. LSCS can be done from 37 weeks onwards because foetal lungs mature by then. But foetuses born at 37 weeks of gestation have more risk of developing respiratory problems, transient tachypnoea of new born, hypothermia, hypoglycaemia and NICU admission.The purpose of this study is to find out appropriate gestational age at which elective LSCS can be performed without adverse maternal and neonatal outcome.Methods: This is an observational comparative study done on 209 antenatal women who underwent elective caesarean section from December 2014 to January 2016.Patients were divided into two groups after taking consent. Maternal parameters like formation of lower uterine segment need for blood transfusion. Neonatal parameters like Apgar score, respiratory distress syndrome and NICU admission with indication and duration were analyzed by chi-square test. Gestational Age and Pre-Op Hb and Post-Op Hb were analyzed by independent ‘t’test.Results: In this study 55% of the pregnant women belong to 38 weeks,45% belongs to 39 weeks. The formation of lower uterine segment was statistically significant and the need for blood transfusion was slightly increased at 39 weeks. But there was no significant difference in Apgar score, Respiratory distress, NICU admission comparing both study groups.Conclusions: Elective caesarean section can be done safely at 38 weeks without affecting maternal and perinatal outcome.
30
Moy, Beverly, Angela R. Bradbury, Paul R. Helft, Moktar Sheikh-Salah, Brian Egleston, Colleen B. Sands, Courtney D. Storm, and Jeffrey M. Peppercorn. "Association between financial relationships with commercial interests and research merit at the ASCO Annual Meeting (AM)." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 6095. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6095.
Full textAbstract:
6095 Background: Financial relationships with commercial interests (COI) are common in cancer research. There are few data examining the correlation between COI and research merit. Meeting placement prominence (MP) and peer review score (PRS) are indicators of research merit. We examined the association between ASCO AM abstracts whose authors disclose COI and both MP and PRS. Methods: We reviewed abstracts presented at the ASCO AM in 2006 and 2008-2011. We evaluated associations between COI disclosed by any author and PRS and MP (order of prominence: plenary session (PS), clinical science symposium (CSS), oral presentation (OP), poster discussion session (PDS), vs. general poster session (GPS)). Chi-square tests, T-tests, and logistic regressions of COI were used to assess associations with MP, PRS, and year. Results: Of 12,446 total abstracts accepted for presentation, 78% of PS, 59% of CSS, 54% of OP, 52% of PDS, and 39% of GPS report at least one COI. Abstracts selected for PS, CSS, OP, and PDS had more COI compared to those selected for GPS (p < 0.05). Stock ownership COI were more frequently disclosed in PS (30%), CSS (30%), OP (22%), and PDS (22%) compared to GPS (16%) (p < 0.05). Employment COI were more frequently reported among abstracts presented at PS (39%), CSS (37%), OP (27%), and PDS (27%) compared to GPS (21%) (p < 0.05). Consultant COI were more likely to have higher MP than GPS placement (OR for PS=5.5; CSS=2.4; OP=2.2; PDS=1.9). Similarly, honoraria COI were more likely to have higher MP than GPS placement (OR for PS=3.9; CSS=1.8; OP=2.1; PDS=1.7). Better PRS was associated with COI (OR 0.17; p < 0.05). The relationship of better PRS with any COI strengthened over time from 2006, 2008-2011 (PRS times year interaction OR=0.65, p<0.001). Conclusions: ASCO abstracts whose authors report COI have higher merit as measured by MP and PRS. This suggests a dependence on industry relationships for access to important data that will lead to prominent cancer research. These relationships will require further investigation and ongoing management. To our knowledge, this is the first study examining the scientific merit of research with relation to COI.
31
Seesen, Mathuramat, Roberto G. Lucchini, Somkiat Siriruttanapruk, Ratana Sapbamrer, Surat Hongsibsong, Susan Woskie, and Pornpimol Kongtip. "Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers." International Journal of Environmental Research and Public Health 17, no. 21 (November 4, 2020): 8140. http://dx.doi.org/10.3390/ijerph17218140.
Full textAbstract:
Insulin resistance is a risk factor for various diseases. Chronic organophosphate exposure has been reported to be a cause of insulin resistance in animal models. This cross-sectional study aimed to evaluate the association between organophosphate exposure and insulin resistance in pesticide sprayers and nonfarmworkers. Participants aged 40–60 years, consisting of 150 pesticide sprayers and 150 nonfarmworkers, were interviewed and assessed for their homeostatic model assessment of insulin resistance (HOMA-IR) level. Organophosphate (OP) exposure was measured in 37 sprayers and 46 nonfarmworkers by first morning urinary dialkyl phosphate (DAP) metabolites. The DAP metabolite levels were not different in either group except for diethylthiophosphate (DETP; p = 0.03), which was higher in sprayers. No significant association was observed between DAP metabolite levels and HOMA-IR. Wearing a mask while handling pesticides was associated with lower dimethyl metabolites (95% CI = −11.10, −0.17). Work practices of reading pesticide labels (95% CI = −81.47, −14.99) and washing hands after mixing pesticide (95% CI = −39.97, −3.35) correlated with lower diethyl alkylphosphate level. Overall, we did not observe any association between OP exposure and insulin resistance in pesticide sprayers and the general population. However, personal protective equipment (PPE) utilization and work practice were associated with OP exposure level in sprayers.
32
Keiffer, Gina, Kelly Hughes, Tingting Zhan, Lindsay Wilde, Neil Palmisiano, and Margaret Kasner. "Outpatient Vyxeos Induction without Planned Admission for Select Patients with Secondary Acute Myeloid Leukemia (sAML) Is Safe and Yields Healthcare Resource Savings." Blood 136, Supplement 1 (November 5, 2020): 2. http://dx.doi.org/10.1182/blood-2020-140055.
Full textAbstract:
INTRODUCTION: With the FDA approval of CPX-351 (Vyxeos; Jazz Pharmaceuticals, Inc.; Palo Alto, CA), the prospect of inducing select patients with acute myeloid leukemia (AML) with a regimen that does not require continuous intravenous in the outpatient (OP) setting became a reality. With the recognition that an OP-induction strategy has the potential benefits of reduced healthcare resource utilization (HRU),1,2 improved quality of life3 and decreased risk of nosocomial infections, some centers have opted to administer Vyxeos in the OP setting and to admit patients only if complications which necessitate inpatient (IP) management occur. The safety and decreased HRU of this approach during consolidation has been demonstrated4 in the study population treated on the pivotal phase III trial (NCT01696084).5 We present the first real-world experience of OP AML induction with Vyxeos without planned hospital admission. METHODS: We performed a retrospective analysis of all patients at our institution treated with OP-Vyxeos without planned admission (OP-Vyxeos) between August, 2017 and June, 2020. Patients were deemed safe for OP induction if they met the criteria outlined in Table 1 at diagnosis or could be stabilized in the hospital and discharged when these criteria were met. Primary and secondary objectives were to evaluate the safety and HRU, respectively, of this approach. The primary endpoint was 30-day mortality. Secondary endpoints included 60-day mortality, rate of adverse effects (AEs), number of hospitalizations, number of hospital days, number of intensive care (ICU) days, and number of days receiving intravenous (IV) antibiotics. When possible, primary and secondary endpoints were compared to patients who received Vyxeos induction in the inpatient setting (IP-Vyxeos) on the phase III trial.5,6 RESULTS: Twenty-five patients received OP-Vyxeos at our institution between August, 2017 and June, 2020 and all were evaluable for the primary endpoint. Baseline characteristics of the OP- and IP-Vyxeos populations are presented in Table 2. The mean age of OP-Vyxeos patients was less than IP-Vyxeos patients (65.4 years vs. 67.7 years) and a higher proportion of OP-Vyxeos patients were <60 years old (20% vs 0%). ECOG Performance Status (PS) was similar between the two groups. Baseline white blood cell count was similar between the two groups but a lower proportion of OP-Vyxeos patients had a platelet count </= 50 x109/L (32% vs. 62%). Clinical efficacy and safety outcomes are presented in Table 3. Complete response (CR) rate for Vyxeos was similar between the OP- and IP-Vyxeos groups (48% vs. 37%), as was time to neutrophil recovery (34 vs. 35 days). There were no early deaths (before 30 days) in the OP-Vyxeos group compared to 9 (5.9%) in the IP-Vyxeos group. Sixty-day mortality was similar between the two groups (4.5% vs. 13.7%). The cause of death in the one OP-Vyxeos patient who died was fungal pneumonia in the setting of presumed refractory leukemia. Febrile neutropenia (FN) with or without documented infection and bleeding (any grade) were the most common AEs in both groups, however, the rates varied significantly between OP- and IP-groups (FN: 88% vs. 68%; bleeding: 28% vs. 74.5%). FN was by far the most common AE in the OP-Vyxeos group and was the admission diagnosis for 91% (32/35) of admissions. HRU-metrics are presented in Table 4. The majority of OP-Vyxeos patients required hospitalization (88%); however, despite an increased mean number of hospitalizations (1.4 vs. 1.0), the median total number of hospital days in the OP group was decreased (22 vs. 28). Three patients (12%) never required hospitalization during OP-Vyxeos induction. The median days spent OP prior to first admission was 8 and 18% (4/22) of patients remained OP for >14 days. CONCLUSIONS: Outpatient Vyxeos induction without planned admission for select patients was safe and resulted in decreased healthcare resource utilization in our cohort of patients. There were no early deaths in the OP-Vyxeos group. Despite an increased mean number of hospitalizations, patients who received OP-Vyxeos had a decreased number of total hospital days. Limitations of this analysis include that this is a small, single-center, retrospective analysis. In the future, we hope to validate our criteria for OP-induction in a larger, multi-institution patient cohort. Disclosures Palmisiano: AbbVie: Research Funding; Genentech: Research Funding. Kasner:Jazz Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees, Research Funding; Otsuka Pharmaceutical: Research Funding.
33
Klein, Erin E., Lowell Weil, Jeffrey R. Baker, Lowell Scott Weil, Wenjay Sung, and Jessica Knight. "Retrospective Analysis of Mini-Open Repair Versus Open Repair for Acute Achilles Tendon Ruptures." Foot & Ankle Specialist 6, no. 1 (October 11, 2012): 15–20. http://dx.doi.org/10.1177/1938640012463052.
Full textAbstract:
Purpose: Debate exists over optimal treatment for acute Achilles tendon ruptures. Recent literature suggests the mini-open technique may provide the reliability of the open repair with the decreased complication rate of non-operative treatment. This retrospective review compares acute tendon ruptures treated with one of two techniques: open repair (TO) or mini-open repair (MOA). Methods & Results: Records were reviewed and 34 patients were found to meet the inclusion criteria for open or mini-open repair of an acute Achilles tendon rupture with follow up of at least 12 months. TO (n=16) and MOA (n=18) had no statistically significant differences in age at time of injury [TO: 41 + 2.5 years (range 20 – 68); MOA: 46 + 2.5 years (range 33 – 73)] or time between injury and surgical repair [TO: 15 + 2 days (range 2 – 30); MOA: 15 + 2 days (range 2 – 30)]. Post-operative VISA-A scores were 82 + 10 (range 42 – 98) and 92 + 5 (range 66 – 100) for TO and MOA, respectively. Significant differences were found in the time between surgical intervention and beginning of rehabilitation [TO: Post op day 37 + 5 (range 21 – 46); MOA: Post op day 19 + 2 (range 7 – 32)] and the time between surgical intervention and full return to activity [TO: Post op month 7 + 1 (range 4 – 11); MOA: Post op month 5 + 0.6 (range 4 – 11)]. Conclusion: These results suggest that the mini-open repair provides acceptable surgical outcomes while optimizing patient function after Achilles tendon repair. Level of Evidence: Therapeutic, Level III: Retrospective Comparative
34
Oosting, Reinoud. "De rol van Ruben in Genesis 37: Analyse van een complexe bijbelse geschiedenis." NTT Journal for Theology and the Study of Religion 66, no. 4 (November 18, 2012): 299–312. http://dx.doi.org/10.5117/ntt2012.66.299.oost.
Full textAbstract:
De afgelopen decennia is er meer aandacht gekomen voor de literaire vormgeving van bijbelse verhalen. De literaire benadering legt de nadruk op de eenheid van de verhalen in hun huidige vorm, en houdt zich niet bezig met de complexe ontstaansgeschiedenis van deze teksten. De analyse van de rol van Ruben in Genesis 37 laat echter zien dat de inhoud en de ontwikkeling van dit hoofdstuk nauw samenhangen. Wie alleen oog heeft voor Ruben als literair personage, mist de portee van zijn optreden in dit verhaal. Bijbelse verhalen dienen daarom niet benaderd te worden als een literair kunstwerk, maar als het product van een levende traditie.
35
Sun, NataliiaYuriyivna. "Solo piano compositions by Hsiao Tyzen in the aspect of performing problems." Problems of Interaction Between Arts, Pedagogy and the Theory and Practice of Education 57, no. 57 (March 10, 2020): 165–77. http://dx.doi.org/10.34064/khnum1-57.10.
Full textAbstract:
Background. The article is dedicated to the piano work of Hsiao Tyzen (1938–2015) – one of Taiwan’s most famous composers. The solo piano compositions of the musician are considered, which make up a significant part of his compositional heritage: three cycles, united under the general name “Poetic Response” – op. 37 (1974), op. 38 (1975) and op. 40 (1977); “The Amazing Grace” (1984), cycle “Memories of Home” op. 49 (1987), consisting of six plays – “Prelude”, “Memory”, “Playground”, “Ancient Taiwanese Melody”, “Elegy”, “Frolicking”; “Farewell Etude”, Op. 55 (1993), “Toccata”, op. 57 (1995), “Dragon Boat Festival”, op. 58 (1996), “Spirit of Taiwan” (1998), “Nana Oh’s Meditation” (1999), “The Angel from Formosa” (1999). This huge layer of music is not sufficiently studied in the performing aspect. The characteristic of the pianistic level of complexity of the compositions under consideration is given, technical and artistic difficulties are revealed. Objectives. The purpose of the study is to identify the main performing tasks in the solo piano compositions of Hsiao Tyzen. Methods of research are based on a set of scientific approaches necessary for the disclosure of its theme. The complex approach, combining the principle of musical-theoretical, musical-historical and performing analysis, is taken as the basis of the methodology. Results. Piano works of Hsiao Tyzen of an early period of art op. 37, 38 and 40, united in the general cycle “Poetic Response”, are devoted to religious themes and include melodies of religious hymns. Combining three diverse piano cycles, the composer builds a kind of complex form of cycles in the cycle. The influence of romanticism in the music of Hsiao Tyzen is felt in his interpretation of melody, harmony, rhythm, tempo and texture. Composers of the twentieth century, especially C. Debussy, influenced the piano compositions of the late period. Since the works created by Hsiao Tyzen have varying degrees of pianistic complexity, it seems important to determine the pedagogical significance of the uncomplicated piano repertoire and the performing tasks that the interpreter of concert compositions faces. The cycle “Memories of Home” op. 49, consisting of six miniatures, is dedicated to the composer’s childhood memories. The main tasks of the pianist in the “Ancient Taiwanese melody” from the cycle “Memories of Home”, op. 49 will be the auditory implementation and development of a touch of legato, the performance of melismatics, the observance of sound balance between hands, the ability to draw a long melodic line, cleverly using a finger swap and moving from one position to another. In the Prelude, the tasks of the performer’s main technical and artistic problems are to accurately reflect dynamic contrasts, the agility of transitions in various textured combinations, the sound realization of polyphony, precise articulation and coordination of small notes in passages. “Memory” requires the performer of the highly professional possession of legato, manifested in the combination of the upper voice of the chord musical fabric, flexible movement skills and an accurate sense of polyrhythmia. In the “Playground” you need to show imaginative imagination, while reflecting the variety of strokes and dynamics specified by the author. “Elegy” requires a deep soulful feeling from a performer, high-quality sounding of a melody, and the formation of long phrases. “Farewell Etude” op. 55 and “Toccata” op. 57 – detailed compositions saturated with romantic technique and imagery. The intonational filling of the plays reflects the national Taiwanese flavor. “Farewell sketch” was the last work of Hsiao Tyzen, written in the tradition of romanticism. The piece is based on the famous Taiwanese folk song “Four Seasons”. The composer places the melody in the middle register, framing on both sides with a luxurious romantic texture. “Toccata” is full of numerous techniques that are difficult enough not only to execute, but even to remember. Frequent change of textured formulas is especially difficult for a pianist, because in addition to the clever execution of a virtuoso texture, you need to keep an accurate rhythmic pulsation. This repertoire is intended for concert performance and requires a pianist of a high professional pianistic level and bright artistry. It requires scale of performance, absolute technical and sound knowledge of the texture, knowledge and auditory presentation of the characteristics of Taiwanese musical culture, and mastery of pedalization. Conclusions. Hsiao Tyzen’s solo piano compositions provide a better understanding of the work of contemporary Taiwanese composers. They are rightfully one of the most striking pages of Taiwanese musical culture and deserve further introduction into a wide international music audience. These works, in our opinion, have high artistic merits and are intended for a different contingent of performers. Their value as a pedagogical and concert repertoire is a vivid imagery, a reflection of the national principle, interesting compositional and sound solutions.
36
Ortiz, Juan, Francis Dube, Pablo Neira, Marcelo Panichini, Neal B. Stolpe, Erick Zagal, and Pedro A. Martínez-Hernández. "Soil Quality Changes within a (Nothofagus obliqua) Forest Under Silvopastoral Management in the Andes Mountain Range, South Central Chile." Sustainability 12, no. 17 (August 22, 2020): 6815. http://dx.doi.org/10.3390/su12176815.
Full textAbstract:
In Chile, 49.1% of the national territory is affected by soil degradation (including erosion and loss of soil organic matter), whereby of the 51.7 Mha that have been historically associated with agricultural-livestock and forestry activities, only 35.5 Mha are being used at the present. Consequently, soil degradation has resulted in the release of about 11.8 Gg yr−1 of carbon (C) equivalent (CO2eq) to the atmosphere. Silvopastoral systems (SPS), however, can increase soil organic C (SOC) through sequestration (C→SOC), improve ecosystem services, and have been internationally recommended for sustainable land use. Therefore, it was proposed to determine the effects of SPS on soils, over five years, in degraded sites that were located in the Ranchillo Alto (SPS-RA) (37°04′52″ S, 71°39′14″ W), Ñuble region. The sites were rated according to previous canopy disturbance levels (+) as follows: open (Op)+++, semi open (SOp)++, and semi closed (SC)+. The analysis was performed on different physical and chemical soil properties (0–5 and 5–20 cm depths), that were expressed as soil indicators (SIND) for chemical and physical properties, which were used to calculate a soil quality (SQ) index (SQI). The results indicated overall SQI values of 37.6 (SC) > 29.8 (Op) > 28.8 (SOp), but there were no significant variations (p < 0.05) in physical SQ, whereas chemical SQ varied in all conditions, mostly at 0–5 cm in Op and SOp. Increases of SOC were also observed (2015–2018 period) of 22.5, 14.5, and 4.8 Mg ha−1 for SOp, Op, and SC, respectively, showing that SPS promote the reclamation of Ranchillo Alto soils.
37
Pavlova, Olga Gennadievna, and Vadim Petrovich Nikolaenko. "Ahmed valve implantation results in neovascular glaucoma patients: Evaluation of short-term and remote." Ophthalmology journal 8, no. 3 (December 15, 2015): 20–23. http://dx.doi.org/10.17816/ov2015320-23.
Full textAbstract:
Objective: to evaluate Ahmed valve implantation results in neovascular glaucoma patients. Methods: standard implantation method was used in 87 patients aged 57-86 years. Check-up examinations were performed in 1 week, 1, 3, 6, 9, 12 and 36 months after surgery. Results: during short-term post-op period (one month after surgery), intraocular pressure normalized in 48 patients. During remote post-op period (6-36 months after surgery), intraocular pressure normalization was achieved in 69 patients (79.2 %), among them in 62 patients (71.2 %) - against the background of IOP-lowering treatment. The main complication was a hemorrhage from anterior chamber angle and iris new vessels that was found in 37 patients (42.5 %), in a quarter of cases it required hyphema washout. In three patients, sustained hypotony developed, in one case it brought to globe sub-atrophy. In two of observed patients, enucleation was performed because of pain syndrome rebound. Conclusions: In 79.2 % neovascular glaucoma patients, the valve implantation led to IOP normalization, while in 71.2 % of cases it required a return to IOP-lowering therapy.
38
Duman, Ibrahim, Eftal Düzyaman, Dursun Esiyok, Hüseyin Vural, and Semih Erkan. "Improving Productivity of Open-pollinated Processing Tomato Cultivars." HortScience 40, no. 6 (October 2005): 1682–85. http://dx.doi.org/10.21273/hortsci.40.6.1682.
Full textAbstract:
In contrast to developed countries open-pollinated (OP) processing tomato cultivars still have a certain market value in Turkey. A total of 26 subpopulations of 6 different OP cultivars (9 of Rio Grande, 5 of Rio Fuego, and 3 of each of C-37, Interpeel, T2 Improved, and VF 6203) were evaluated in two experimental sites in Marmara Region and Aegean Region. A high degree of phenotypic variance for yield (kg/plant) was found for most subpopulations which revealed the variation for yield amongst individuals, and hence the possibility to select for superior plants. Eighteen populations were developed by two cycles of mass selection conducted within the initial populations in both regions. Most progeny populations significantly exceeded their source cultivars in yield. Heritability estimates occurred generally parallel to that of yield increases of the progenies, which were slightly higher in the Karacabey trial (Marmara Region) as compared to the Muradiye trial (Aegean Region). Results were discussed from the point of view of the resource-poor farmers conducting low-input agriculture.
39
Patil, Neelkant S., Shodhan Raghuram Aithal, and Hemamalini Gururaj. "Clinical and Socio-Demographic Profile of Poisoning Cases - A Retrospective Study from Dharwad, Karnataka." Journal of Evidence Based Medicine and Healthcare 8, no. 19 (May 10, 2021): 1386–90. http://dx.doi.org/10.18410/jebmh/2021/264.
Full textAbstract:
BACKGROUND Poisoning is a major healthcare issue in our country. There is a recent increase in trend of non-OP compound usage. We wanted to study the socio-demographic, and clinical profile in terms of outcome with different poisons. METHODS A total of 100 patients were included in this retrospective study conducted in tertiary care hospital in Northern Karnataka. Data was collected and analysed using pre-structured questionnaire regarding demographic details, mode of poisoning, precipitating factors, duration of hospitalization, and final outcome. Descriptive statistics and chi-square test were done to find the association between the two attributes. Odds ratio was also calculated. P < 0.05 was considered to be statistically significant. RESULTS Mean age of the study population was 31.48 years. Majority of the study population was females (63 %, N = 63), homemakers or students (32 % each), illiterates (68 %) and married (62 %). Mode of poisoning was suicidal in 78 % of the patients. Among the compounds used for poisoning, non-OP compoundespecially pharmaceutical drugs accounted for 40 % of the cases. Mean duration of hospital stay was 5 days and 16 % had prolonged hospitalisation. Family fight, depression, and consumption of ethanol at the time of poisoning were the common precipitating factors. Mortality was 3 %. Homemakers and students (χ2 = 4.33, df = 1, OR = 3.33, 95 % CI = 1.02-10.7, P < 0.05), unmarried individuals (χ2 = 5.31, df = 1, OR = 3.75, 95 % CI = 1.16 - 12.1, P < 0.05) and teetotallers (χ2 = 18.94, df =1, OR=11, 95 % CI = 3.26 - 37, P < 0.05) had higher proportion of non-OP compound consumption and this was statistically significant. CONCLUSIONS Educational awareness and regulation of drug availability over the counter, to prevent such emergencies, is essential. Awareness of good mental health and support systems has to be publicised to prevent the precipitating factors. KEYWORDS Poisoning, Drug Overdose, OP Compound, India
40
Weekes, Danielle G., Eric D. Wicks, Richard E. Campbell, Christopher Hadley, Aaron Carter, Zaira Chaudhry, Matthew D. Pepe, Bradford S. Tucker, Kevin B. Freedman, and Fotios P. Tjoumakaris. "Do Relaxation Exercises Decrease Postoperative Pain after Rotator Cuff Repair? A Randomized Controlled Trial." Orthopaedic Journal of Sports Medicine 7, no. 7_suppl5 (July 2019): 2325967119S0038. http://dx.doi.org/10.1177/2325967119s00380.
Full textAbstract:
Objectives: During the last decade, concern about opioid dependence and abuse has spurred an increasing interest within orthopedic surgery to decrease reliance on narcotics for pain management. Non-pharmacologic interventions, such as patient opioid education, can decrease narcotic consumption after arthroscopic rotator cuff repair (ARCR). Another non-pharmacologic intervention, the use of relaxation exercises, has been promoted for pain management following surgical procedures; however, its’ effect has not been investigated following ARCR. The purpose of this investigation was to evaluate the effects of relaxation exercises on post-operative pain and narcotics use after ARCR. Methods: This was a prospective, randomized, controlled trial evaluating 151 consecutive patients undergoing ARCR. The treatment group (n: 75) received and reviewed relaxation education materials including a 5 minute video explaining relaxation breathing techniques, while the control group (n: 75) received no relaxation education materials. Both groups received a standardized pre-operative interscalene nerve block as well as the same standardized post-op care, including oxycodone 5mg/acetaminophen 325 mg, and cryotherapy. Patients recorded a 5-day journal of their pain level and opioid consumption. Patients were then queried with the American Shoulder and Elbow Surgeons (ASES) Shoulder Score, Single Assessment Numerical Evaluation (SANE) score, and Visual Analog Score (VAS) for pain pre-operatively, and at 2, 6, 12, 18, and 24 weeks post-operatively. Additionally, patients were given a follow-up survey at 2 weeks post-operative to assess subjective pain relief efficacy of the relaxation techniques. T-test analyses were utilized to compare differences between the treatment group and the control group. Results: Ninety-five percent of patients completed the follow-up survey. Sixty-three percent (43/68) of study group patients reported that the relaxation techniques decreased their pain levels, while 37% said that it had no effect on their pain. There were no significant differences between the study and control groups in mean post-op VAS pain scores on post-op day 1 (treatment: 55.40, control: 59.5; p= 0.94), post-op day 2 (treatment: 56.15, control: 56.93; p= 0.88), post-op day 3 (treatment: 48.38, control: 47.07; p= 0.52), post-op day 4 (treatment: 40.03, control: 45.54; p= 0.79) and post-op day 5 (treatment: 38.57, control: 40.57; p= 0.71). At two weeks post-op the study group consumed significantly less narcotics than the control group (mean: 21.7 doses vs. 29.7; p= 0.016, Cohen’s d: 0.42), and 51% were still performing the relaxation techniques. There were no significant differences in ASES and SANE scores at each time point throughout the study period. Conclusion: Although nearly two-thirds of patients in the treatment group believed that the use of relaxation breathing techniques decreased their pain, there was no difference in pain measures between the treatment group and the control group. However, the treatment group did utilize less opioid medication than the control group. While the effect on post-op pain is uncertain, the use of relaxation techniques can provide an easy to implement, non-pharmacologic strategy to significantly decrease narcotics consumption after ARCR.
41
Erho, Nicholas, Ismael A. Vergara, Christine Buerki, Mercedeh Ghadessi, Anamaria Crisan, Thomas Sierocinski, Zaid Haddad, et al. "Discovery of a biomarker signature that predicts upgrading or upstaging in patients with low-risk prostate cancer." Journal of Clinical Oncology 30, no. 30_suppl (October 20, 2012): 37. http://dx.doi.org/10.1200/jco.2012.30.30_suppl.37.
Full textAbstract:
37 Background: More than 90% of patients diagnosed with organ-confined prostate cancer (PCa) choose upfront definitive treatment (e.g., radical surgery) even though many are excellent candidates for delayed therapy (i.e., active surveillance [AS]). Therefore, patients may suffer from the adverse effects of treatment without gaining any benefit. Biomarker signatures that predict tumour aggressiveness are promising tools for identification of patients suited for AS. In this study, we use a transcriptome-wide assay to develop a biomarker signature for patients assessed as low risk at diagnosis who are upgraded or upstaged following radical prostatectomy (RP). Methods: Gene expression data of 56 RP samples from the Memorial Sloan Kettering Oncogenome Project (GSE21034) which met the low risk criteria (i.e., biopsy Gleason score (GS) ≤ 6, clinical stage T1 or T2A, and pre-operative PSA (pre-op PSA) ≤ 10 ng/ml) were used to develop the signature. Of these tumors, 31 underwent upgrading or upstaging (defined by pathological GS ≥ 7 or a pathological tumor stage > T3A). In the training set (n = 29) a median fold difference filter (MFD > 1.4) was applied to select features. The top 16 t-test ranked features were modelled with a K-nearest-neighbor (KNN) classifier (k = 3) which predicts upgrading/upstaging events. Results: The KNN was applied to the test set (n = 27) and achieved an area under the receiver operating characteristic curve (AUC) of 0.93, significantly better discrimination than pre-op PSA (AUC = 0.52) or tumor stage (AUC = 0.63). Compared to the null model’s accuracy of 56%, the KNN correctly predicts 81% (p-value < 0.005) of the upgrading/upstaging events. In multivariable analysis with pre-op PSA, tumor stage, and age at diagnosis, the KNN remained the only significant (p < 0.05) factor with an odds ratio of 2.7. Conclusions: A 16 marker signature was identified from RP specimens and shown to accurately segregate true low risk patients from those which transitioned to higher risk. Validation studies of this signature in prospectively designed cohorts of active surveillance candidates are underway to determine if the molecular signature can improve treatment and management decisions for low risk PCa patients.
42
Lee, J. H., Y. M. Yoo, E. M. Jung, C. Ahn, D. N. Tran, S. Y. Park, B. Lee, B. H. Jeon, T. H. T. Nguyen, and E. B. Jeung. "190 Effects of endocrine-disrupting chemical on calcium signalling in cardiomyocyte differentiation from mouse embryonic stem cells." Reproduction, Fertility and Development 31, no. 1 (2019): 219. http://dx.doi.org/10.1071/rdv31n1ab190.
Full textAbstract:
Endocrine-disrupting chemicals (EDC) are substances similar to steroid hormones that can disturb normal physiological functions of male and female reproductive organs. Endocrine-disrupting chemicals tend to bind to steroid hormone receptors. Sex steroid hormones modulate calcium signalling in the cardiac muscle in early embryo development. Among the steroid hormones, progesterone (P4) has been reported to affect blood pressure and other aspects of the cardiovascular system. The EDC that have similar structure to P4, such as octyl-phenol (OP) and bisphenol A (BPA), are potentially harmful to development of the heart. To confirm the effect of OP and BPA on early differentiation of mouse embryonic stem cells (mES) into cardiomyocytes, the hanging-drop method with mESC cell line (ES-E14TG2a) was used for forming embryoid bodies. Pluripotent mESC were cultured in basal medium with leukemia inhibitory factor and grown on mitomycin C-treated mouse embryonic fibroblasts in a 60-mm plate at 37°C in a 5% CO2 humidified tissue culture incubator with basal medium consisting of DMEM/F-12 supplemented with nonessential amino acids, 10% heat-inactivated and certified fetal bovine serum (FBS), 2-mercaptoethanol, penicillin, and streptomycin. The mouse embryoid bodies (mEB) were suspended onto 6-well plates and cultured with differentiation medium containing steroid-free FBS without leukemia inhibitory factor. Progesterone, OP, and BPA were added on Day 2 from mEB attachment. In addition, mifepristone (RU486), an antagonist for progesterone receptor (PR), was used to confirm the effect of P4 through PR. To determine whether RU486 is capable of attenuating the inhibition effect of P4, RU486 was added for 1 day starting on Day 11. Assessment of cardiomyocyte differentiation was determined by checking the number of beating cell populations divided by the total number of attached mEB. Total RNA was extracted using Trizol reagent and synthesised to cDNA using Moloney murine leukemia virus (MMLV) reverse transcriptase. Messenger RNA level was assessed using quantitative real-time PCR. To investigate calcium signalling, the mRNA levels of calcium channel gene Trpv2 and contraction-related genes Ryr2, Cam2, and Mylk3 were analysed. Beating ratio was decreased in P4, OP, and BPA treatments. Data were analysed by one-way ANOVA followed by Tukey’s multiple comparison tests, and P<0.05 was considered statistically significant in least 3 different replicates. The mRNA level of Pgr was significantly increased in P4, OP, and BPA-treated group. However, the mRNA level of calcium channel gene Trpv2 was significantly decreased in the P4, OP, and BPA-treated group. Expression of contraction-related genes such as Ryr2, Cam2, and Mlck3 were significantly decreased in the P4, OP, and BPA-treated group. In addition, treatment with RU486 rescues altered calcium channel gene and contraction-related genes. Taken together, these results suggest that OP and BPA may affect the differentiation of mESC into cardiomyocyte and disrupts differentiation of cardiomyocytes.
43
Wetzstein, Gene A., Jeffrey E. Lancet, Jennifer E. Kallner, Jeffrey M. Sivik, Viet Q. Ho, Timothy J. George, Sheetal Desai, Shanel Fisher, Michael D. Newton, and Alan F. List. "Safety, Feasibility, and Cost-Effectiveness with Outpatient Administration of High-Dose Cytarabine Consolidation in Acute Myeloid Leukemia." Blood 112, no. 11 (November 16, 2008): 2405. http://dx.doi.org/10.1182/blood.v112.11.2405.2405.
Full textAbstract:
Abstract Introduction: High-dose cytarabine (HiDAC) consolidation chemotherapy is frequently used in acute myeloid leukemia (AML) patients less than 60 years of age. Traditionally, the potential risk for neurotoxicity, which has been reported to occur in 8–26% of patients, has limited its administration to the inpatient setting with a median length of stay of 5 days. Institutional retrospective data revealed the incidence to be much lower than previously reported with grade III/IV neurotoxicity in only 0.7% of cycles (N=267). As a result, we developed a comprehensive outpatient (OP) approach for the administration of HiDAC utilizing a pre-printed order and monitoring forms, pre-defined eligibility criteria/risk factors, administration/screening checklist, standard ancillary medications, designated scheduling, patient counseling, and written instructions for follow up. The benefits of OP administration may include improved patient satisfaction and decreased institutional costs and constraints on inpatient resources. However, there does not appear to be any published literature to date describing the OP administration of HiDAC. We report herein on the safety, feasibility, and outcomes of 43 patients receiving HiDAC consolidation therapy (n=88 cycles) between September 2006 and July 2008. Methods: Patients < 60 yo received 3 g/m2 over 1 hour every 12 hours on days 1, 3, and 5 and the dose was reduced to 1.5 g/m2 for pts ≥ 60 yo. All cycles of HiDAC were dosed based on age, renal, and hepatic function. There were no empiric dosage adjustments based on renal function alone. Post-treatment, patients received antibiotic prophylaxis and growth-factor support. Patients returned twice weekly for blood work until neutrophil and count recovery. Results: Forty-three patients received 88 cycles of HiDAC as an OP. The median patient age was 49 yrs (23–74) with 16% being over 60. Patient baseline characteristics of the OP group were similar to the inpatient group from our institutional review with respect to age, body surface area, gender, and race. Diagnosis, history of CNS radiation/disease, intrathecal chemotherapy, alcohol abuse, cumulative cytarabine dosage, and concurrent medications were also similar between the two groups. Only 1 patient was ineligible to receive OP therapy which was the result of both renal (estCL < 60mL/min) and hepatic (alk phos > 3X ULN) risk factors. Two patients with moderate renal insufficiency (est CL 30–60 mL/min) received full dose HiDAC without adverse event. All 43 patients successfully completed their full course of therapy. During the 88 cycles, there were no cases of clinically significant neurotoxicity (≥ grade III). There were 3 instances of grade I nystagmus. In all cases, therapy was completed without interruption. Rates of admission to the hospital post HiDAC OP consolidation for neutropenic fever (NF) was comparable to the inpatient group from our institutional review, occurring in 26% and 37% (p=0.07), respectively. All admissions post HiDAC OP was secondary to NF with the exception of one patient who was admitted for mucosal bleeding. Conclusions: In the present analysis, we confirm the safety and feasibility of OP-based HiDAC chemotherapy for the management of AML patients in remission. If patients are dosed and monitored properly, HiDAC can be successfully transitioned to the OP setting. With the implementation of this approach, we have improved patient convenience and satisfaction, decreased pressure on inpatient resources (nearly 450 days of hospital bed use), while maintaining similar rates of hospital re-admission. With proper patient selection, dosing, and education of both providers and patients, HiDAC can be safely administered in the OP setting and has become our standard of care.
44
Cavanagh, Lynn. "Marcel Dupré's “Dark Years”: Unveiling His Occupation-Period Concertizing." Articles 34, no. 1-2 (May 26, 2015): 33–57. http://dx.doi.org/10.7202/1030869ar.
Full textAbstract:
Examination of organist Marcel Dupré’s collected concert programs reveals that, of 137 he performed during the German occupation, 14 bear signs of funding by the German Embassy or the military government’s Propaganda Department. Dupré, though, would have participated in good conscience out of personal pride in France’s musical past. Post-Liberation punishments of French musicians who “collaborated with the enemy” were applied so inconsistently as to explain why he thereafter suppressed the extent and nature of his Occupation-period concertizing. This fuller picture of his activities potentially sheds light on his Second World War–period compositions, particularly Évocation, op. 37.
45
Becouarn, Y., S. Mathoulin-Pélissier, M. Rivoire, A. Ayav, J. Arnaud, A. Sa Cunha, R. Brunet, M. Fonck, C. Bellera, and S. Evrard. "Efficacy of intraoperative radiofrequency ablation (IRFA) combined or not with resection to treat unresectable colorectal metastases, with or without preoperative chemotherapy: The ARF2003 Study (NTC 00210106): Preliminary results." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 4095. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4095.
Full textAbstract:
4095 Background: Only few patients suffering from colorectal metastases (CRM) can have surgery and thus hope for a 40% 5-year survival rate. Adding IRFA to resection may improve the efficacy of surgery. Methods: The primary objective was to evaluate the efficacy of IRFA combined or not with resection in terms of 3-month complete hepatic response (CHR) in patients with unresectable CRM. Secondary endpoints were overall survival (OS), disease-free survival (DFS), morbidity and quality of life. A phase II study based on a Simon's two-stage design was conducted in 6 university French hospitals. Number of subjects estimated was 53, with 19 for the 1st stage. At the end of the 1st stage, 12 CHR were required to continue recruiting. At the end of 2nd stage, 37 CHR would be required to claim efficacy. Results: Fifteen of the first 19 patients exhibited CHR allowing the study to pursue accrual which ended in Nov 08; some patients are still followed up. As of Nov 08, data had been collected on 47 patients (mean age 61 years): 6 had RFA alone (13%), 37 had RFA and resections (82%), 2 could not be treated (4%). Median number of CRM was 5 (1–12). All had chemotherapy pre-op and 12 post-op (29%). Three-month data were available for 36 patients: 1 patient died on the 3rd week following intervention. Scans were available for 35 patients (independently reviewed). Of these, 29 had CHR (83%); 13 had 3-month morbidity (37%). The median follow-up was 15 months. One-year OS and DFS rates were 92.3% and 26% respectively. Analysis on all 53 patients will be communicated in June 09. Conclusions: These preliminary results suggest that IRFA combined or not to resection may be efficient in treating unresectable diseases despite their more aggressive pattern. This corroborates the EORTCC CLOCC Trial findings which demonstrated IRFA superiority upon chemotherapy alone. IRFA could thus be valuably associated to resection in treating patients with colorectal metastases that resection alone could not handle. No significant financial relationships to disclose.
46
Malanovic, Nermina, Jan Wouter Drijfhout, Manfred Kriechbaum, Maria Schmuck, Anna de Breij, Peter Nibbering, and Karl Lohner. "Point Mutation in the Hydrophobic Region Drives Selectivity and Activity of OP-145, a Derivative of Human Cathelicidin LL-37." Biophysical Journal 106, no. 2 (January 2014): 442a. http://dx.doi.org/10.1016/j.bpj.2013.11.2487.
Full text
47
Jepsen, Randi, Eivind Aadland, Lesley Robertson, Ronette L. Kolotkin, John Roger Andersen, and Gerd Karin Natvig. "Physical Activity and Quality of Life in Severely Obese Adults during a Two-Year Lifestyle Intervention Programme." Journal of Obesity 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/314194.
Full textAbstract:
It is unknown how changes in physical activity may affect changes in quality of life (QoL) outcomes during lifestyle interventions for severely obese adults. The purpose of this study was to examine associations in the patterns of change between objectively assessed physical activity as the independent variable and physical, mental, and obesity-specific QoL and life satisfaction as the dependent variables during a two-year lifestyle intervention. Forty-nine severely obese adults (37 women;43.6±9.4years; body mass index42.1±6.0 kg/m2) participated in the study. Assessments were conducted four times using Medical Outcomes Study Short-Form 36 Health Survey (SF-36), Obesity-Related Problems (OP) scale, a single item on life satisfaction, and accelerometers. The physical component summary (PCS) score and the mental component summary (MCS) score were used as SF-36 outcomes. Associations were determined using linear regression analyses and reported as standardized coefficients (stand. coeff.). Change in physical activity was independently associated with change in PCS (stand. coeff. = 0.35,P=.033), MCS (stand. coeff. = 0.51,P=.001), OP (stand. coeff. = −0.31, P=.018), and life satisfaction (stand. coeff. = 0.39,P=.004) after adjustment for gender, age, and change in body mass index.
48
Ojha, A., and YK Gupta. "Study of commonly used organophosphate pesticides that induced oxidative stress and apoptosis in peripheral blood lymphocytes of rats." Human & Experimental Toxicology 36, no. 11 (December 9, 2016): 1158–68. http://dx.doi.org/10.1177/0960327116680273.
Full textAbstract:
In a previous study, we have found that organophosphate (OP) pesticides such as chlorpyrifos (CPF), methyl parathion (MPT), and malathion (MLT) significantly induced genotoxicity in peripheral blood lymphocytes of rats. To explore the mechanism of OP-induced genotoxicity, we measured the formation of DNA interstrand cross-links (DICs) and apoptosis in peripheral blood lymphocytes of rats. Peripheral blood lymphocytes of rats were treated with CPF, MPT, and MLT individually and in combination at concentrations of 0.1 and 0.25 LC50 for 2, 4, 8, and 12 h at 37°C. Lipid peroxidation (LPO) was measured as a biomarker of oxidative stress. Apoptosis induced by CPF, MPT, and MLT individually and in combination was determined by measuring the intracellular level of active caspase-3 and caspase-9 by spectrofluorimetry. We found significant dose- and time-dependent increases in LPO, DICs formation and increase of intracellular active caspase-3 and caspase-9 in exposed peripheral blood lymphocytes of rats. These findings suggest that the studied pesticides have potential to induce oxidative stress, cause DNA adduct formation, and cause failure of adduct repair, which leads to apoptosis that is partially mediated by activation of intracellular caspase-3 and caspase-9.
49
Rankin, Danielle A., Zaid Haddadin, loren lipworth, Jon Fryzek, Mina Suh, Donald S. Shepard, Rendie McHenry, et al. "1406. Comparison of Clinical Presentations and Burden of Respiratory Syncytial Virus in Infants Across Three Distinct Healthcare Settings." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S711. http://dx.doi.org/10.1093/ofid/ofaa439.1588.
Full textAbstract:
Abstract Background Respiratory syncytial virus (RSV) accounts for the majority of lower respiratory tract illnesses in hospitalized infants. In the U.S., RSV hospitalizations are well characterized; yet, emergency department (ED) and outpatient (OP) visits are underrecognized. We evaluated the burden of RSV across three distinct healthcare settings during one respiratory season. Methods From 12/16/19-4/30/20, we conducted a prospective RSV surveillance study among Davidson County, TN infants under one year who presented to an inpatient (IP), ED, or one of four OP clinics with either fever or any upper respiratory (i.e., cough, earache, nasal congestion, rhinorrhea, sore throat) and/or lower respiratory [i.e., wheezing, crackles, rales, diminished breath sounds, shortness of breath (SOB)] symptoms. Demographic and illness history were collected during parental/guardian interviews, followed by medical chart abstraction. Nasal swabs were collected and tested for RSV using Luminex® NxTAG RPP. Due to the COVID-19 pandemic, on 3/16/20 enrollment at three of the four OP clinics ceased. Results A total of 627 infants were screened, of whom 473 (75%) were confirmed eligible, 364 (77%) enrolled, 361 (99%) were tested for RSV of which 101 (28%) were RSV+ (IP=37, ED=18, OP=46) (Figure 1). Compared to RSV-negative subjects, RSV+ subjects were younger (6.6 vs. 4.9 months, p< 0.001), 56% were male and 48% white. By setting, infants in the OP setting were older than those seen in the IP and ED [(p=0.002), Figure 2]. Compared to infants in the OP setting, hospitalized infants were more likely to present with SOB and rhonchi/rales, but less likely to have only upper respiratory symptoms (Figure 3) and be African American (p=0.046). Infants in the IP setting had a higher proportion of clinical RSV diagnostic testing (73%) compared to the ED (39%) and OP (28%) settings (p< 0.001). Figure 1. Davidson County Infants with RSV by MMWR Week and Healthcare Setting (n=101) Figure 2. Cumulative Enrollment of Davidson County Infants with RSV by Age in Months and Healthcare Setting (n=101) Figure 3. Proportion of Davidson County Infants with RSV Showing each Clinical Symptom, by Healthcare Setting Conclusion Two-thirds of RSV+ infants sought care from either an OP or ED setting, with nearly all hospitalized infants presenting with both upper and lower respiratory symptoms. The underutilization of diagnostic testing in the OP settings may underestimate the true burden of RSV. Future studies are essential to document the true prevalence of RSV in order to assess the need and impact of new interventions (e.g., immunizations, antivirals). Disclosures Danielle A. Rankin, MPH, CIC, Sanofi Pasteur (Grant/Research Support, Research Grant or Support) Zaid Haddadin, MD, CDC (Grant/Research Support, Research Grant or Support)Quidel Corporation (Grant/Research Support, Research Grant or Support)sanofi pasteur (Grant/Research Support, Research Grant or Support) Jon Fryzek, PhD, MPH, EpidStrategies (Employee) Mina Suh, MPH, International Health, EpidStrategies (Employee) Donald S. Shepard, PhD, Sanofi Pasteur (Grant/Research Support) Natasha B. Halasa, MD, MPH, Genentech (Other Financial or Material Support, I receive an honorarium for lectures - it’s a education grant, supported by genetech)Karius (Consultant)Moderna (Consultant)Quidel (Grant/Research Support, Research Grant or Support)Sanofi (Grant/Research Support, Research Grant or Support)
50
Seaton, Douglass. "Felix Mendelssohn Bartholdy - Felix Mendelssohn Bartholdy, Organ Works: Preludes and Fugues Op. 35 & 37 Adam Lenart org. Organ arrangement of Op. 35 by Adam Lenart MDG 906, 2013 (1 CD: 79 minutes)." Nineteenth-Century Music Review 12, no. 1 (June 2015): 173–76. http://dx.doi.org/10.1017/s1479409815000099.
Full text