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Gupta, Aarti. "Evaluation of Integrated OPAT Service in Tallaght University Hospital under the governance of a new Infectious Diseases Department." International Journal of Integrated Care 25 (April 9, 2025): 313. https://doi.org/10.5334/ijic.icic24437.
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Background: OPAT service has been in place in Tallaght University Hospital (TUH), Dublin; Republic of Ireland since 2013 and patients have been discharged under the governance of their primary teams since that time. The newly established Infectious Diseases (ID) department commenced the governance of OPAT Service at TUH on Sept 9th, 2022. A six-month evaluation of the new service was undertaken using Irish National guidelines1 as the standard and also to estimate the hospital bed days saved and financial savings via OPAT Service under the new governance. Methods: The project was commenced after ethical approval from the local QI department. Data was collected prospectively from the OPAT patient database maintained securely for all patients discharged between 09/09/2022 and 31/03/2023. Results: 48 patients were discharged on OPAT during the analyzed duration with 85.4% (n=41) discharged on H-OPAT and 95.8% (n=46) within 48 hours of referral after securing PICC line access in 95.8 % (n=46). Community Intervention team, south Dublin was among the highest OPAT service providers in 75% (n=36). Bone and Joint infections were the most common indication for OPAT in 54.16% (n=26) with Ceftriaxone most commonly used antibiotic. The frequency of polypharmacy was 56.2% (n=27) and excessive polypharmacy was 14.5% (n=7). Thirty (62.5%) patients received targeted culture-based therapy whereas 37.5% (n=18) were culture-negative and treated empirically. Overall 91% (n=44) of patients completed the planned course with Two (4.15%) readmissions for OPAT-related causes. Approximately, a total of 1252 bed days were saved equating to an approximate cost saving of 1,194,408 euros. Conclusion: Overall OPAT was demonstrated to be a safe and cost-saving service for the treatment of patients. The study also indicated that for patients on OPAT, hospital readmissions can be avoided with regular dedicated weekly follow-ups in the OPAT clinic and by having clinical space and resources for unscheduled reviews if any problems arise on days other than the OPAT clinic days. Overall H-OPAT was utilised more commonly than S-OPAT with the Community Intervention team being the most popular provider of OPAT service. The barriers to S-OPAT will continue to be explored and addressed in the future.
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Umanzor, Gerardo, Hope S. Rugo, Francisco J. Barrios, et al. "Abstract P1-16-05: Oraxol + Encequidar (OPac+E) vs IV paclitaxel (IVPac) in the treatment of patients with metastatic breast cancer (mBC) (Study KX-ORAX-001): Subgroup survival analysis of patients with hepatic dysfunction." Cancer Research 82, no. 4_Supplement (2022): P1–16–05—P1–16–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-16-05.
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Abstract Background: IVPac is widely used to treat patients with breast cancer. oPac+E is oral paclitaxel in combination with Encequidar, an oral, minimally absorbed, specific p-glycoprotein inhibitor that enables the absorption of oral paclitaxel. Results of the phase III trial, KX-ORAX-001, were presented at SABCS, 2019, Abstract # GS6-01. At the time of the database lock for the final analysis of the primary endpoint of confirmed tumor response rate, analyses of PFS and OS were performed. The confirmed tumor response rate was significantly higher in the oPac+E group vs IVPac (35.8% vs 23.4%, p=0.011 ITT, population). The median overall survival, as of Sept 2020 presented at SABCS 2020, Abstract# PD1-08 was 22.7 months vs 16.5 months, respectively favoring oPac. Analysis of safety data demonstrated that patients with elevated liver tests (at screening or baseline), were at increased risk of serious and early complications of neutropenia including sepsis, septic shock, febrile neutropenia which could be fatal. A post hoc, subgroup analysis of survival for patients with elevated liver tests was conducted. Methods: Study KX-ORAX-001 was a phase III, randomized, international study in women with mBC for whom treatment with IVPac was recommended. Eligible patients were randomized 2:1 to receive oPac+E or IVPac. Patients received treatment until discontinuation due to progressive disease or toxicity. oPac 205 mg/m2 was given once daily for 3 days weekly. E 12.9 mg was given 1 hour before each dose of oPac. IVPac 175 mg/m2 was infused over 3 hours every 3 weeks. The primary endpoint was efficacy, defined as tumor response confirmed by BICR at two consecutive evaluations. Key secondary endpoints included PFS, OS. Safety was monitored throughout the study. Results: A total of 402 mBC patients were randomized (oPac+E 265: IVPac 137) and represent the ITT population of which 399 subjects were dosed. 122 patients (oPac+E 74, IVPac 48) had elevated AST, or bilirubin (NCI ODWG mild category) at screening or predose/baseline. The subjects were generally balanced between treatment groups for mean age (55 vs 57 years), extent of tumor metastases, and tumor markers ER/PR+ HER2- (62% vs 63%), ER/PR- HER2- (11% vs 15%). For subjects receiving OPac+E, the median survival was 18.9 months vs 10.1 months for subjects receiving IVPac; with a hazard ratio of 0.593 (95.5% CI 0.382 - 0.921) favoring OPac+E.Greater than 65% of subjects had a survival event at the time of this analysis. Conclusion: Although patients with mBC and mild hepatic dysfunction at baseline are at increased risk of early serious neutropenic and infectious/septic complications after treatment with oPAC+E, this risk is counterbalanced by an increase in overall survival. (NCT 02594371) Citation Format: Gerardo Umanzor, Hope S Rugo, Francisco J Barrios, R H Vasallo, Marco A Chivalan, S Bejarano, Julio Roberto Ramirez, Luis Fein, R D Kowalyszyn, D L Cutler, D Kramer, H Wang, R MF Kwan. Oraxol + Encequidar (OPac+E) vs IV paclitaxel (IVPac) in the treatment of patients with metastatic breast cancer (mBC) (Study KX-ORAX-001): Subgroup survival analysis of patients with hepatic dysfunction [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-16-05.
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Brown, Brittany, Thomas J. Dilworth, Margaret Cook, and Charles F. Brummitt. "2082. Evaluation of Outpatient Parenteral Antimicrobial Therapy (OPAT) Processes and Outcomes Among Patients Within an Integrated Health System." Open Forum Infectious Diseases 6, Supplement_2 (2019): S702. http://dx.doi.org/10.1093/ofid/ofz360.1762.
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Abstract Background Successful management of outpatient parenteral antimicrobial therapy (OPAT) optimizes outcomes and reduces cost. We examined (i) local OPAT processes and outcomes, (ii) whether OPAT constraints favoring once daily antibiotics promoted suboptimal therapeutic choices, and (iii) whether these data could drive OPAT improvements. Methods Patients ≥ 18 years of age who received > 48 hours of OPAT at five infusion centers within a single health-system from January 1, 2018 to March 1, 2018 were eligible for review. The following patient- and treatment-level data were collected: age, gender, drug allergies, laboratory studies and frequency, OPAT indication, infection source, pathogen(s), antibiotic sensitivities, antibiotic therapy and duration, electronic order set used, prescriber specialty, evidence of failed prior oral or intravenous (IV) therapy and IV access type. The primary outcome was OPAT success: the clinical resolution of the infection without relapse within 30 days of antibiotic therapy completion. Secondary outcomes included change in antibiotic therapy due to lack of clinical improvement, adverse drug reactions and IV access complications. A sub-analysis of patients who received daptomycin and/or ertapenem was also performed. OPAT practice was compared with 2018 Infectious Diseases Society of America OPAT guidelines (Norris et al. Clin Infect Dis. 2019;68(1):e1-e35). Results A total of 108 patients were evaluated. Patient demographics, treatment and outcomes are shown in Table 1. The most common OPAT indications were bone/joint, bacteremia and skin infection. Third-generation cephalosporins, carbapenems and daptomycin were most commonly prescribed. In 34.3% and 24.2% of daptomycin and ertapenem cases, respectively, β-lactam therapy could have been utilized. Assessment of prior failed antibiotic therapy, patient allergies and pathogen-site pairing found 28.7% of patients were eligible for oral therapy upon OPAT initiation. Conclusion Several components of our local OPAT aligned with current guidelines. Initial OPAT patient selection may benefit from added scrutiny. Given the high volume of once daily antibiotics administered for convenience there is an internal opportunity to facilitate multi-daily infusions. Disclosures All authors: No reported disclosures.
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Yuliani, Yuliani, Safri Ismayana, Rani Maharani, Fitri Widiantini, and Danar Dono. "Evaluation and possible mechanism of beet armyworm (Spodoptera exigua Hubner) resistance to chlorpyrifos and their sensitivity to neem oil insecticides." Open Agriculture 5, no. 1 (2020): 785–91. http://dx.doi.org/10.1515/opag-2020-0078.
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AbstractThe uncontrolled and excessive use of insecticides on Spodoptera exigua can cause resistance. The aim of this study is to test resistance of S. exigua to chlorpyrifos and determine the possible mechanism of resistance to S. exigua. The resistance assay was carried out on chlorpyrifos by determining the level of resistance by the comparison of LC50 between the field samples and the standard samples. The resistivity of S. exigua was correlated with the activity of acetylcholinesterase (AChE), esterase, and glutathione S-transferase (GST) enzymes. The samples of S. exigua were also tested for their sensitivity to neem oil insecticides. The results showed that S. exigua samples from Brebes and Cipanas had a resistance ratio (RR) of 5.50 and 3.26, respectively. The results of the present study indicate that the insensitivity of the AChE and the high activity of the GST play a significant role in the mechanism of S. exigua resistance to chlorpyrifos. However, the esterase has fewer roles in the S. exigua resistance mechanism for both samples. In addition, the results of neem oil insecticides test showed that S. exigua from Brebes and Cipanas samples is sensitive to the insecticide with the RR value less than 1; therefore, this biopesticide has the opportunity to manage resistant pests. A novel mechanism for insecticide resistance by insect was proposed.
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Hahnekamp, Yanik. "A Quantitative Study of the Linear Pottery Culture Cemetery “Aiterhofen-Ödmühle”." Open Archaeology 7, no. 1 (2021): 972–85. http://dx.doi.org/10.1515/opar-2020-0161.
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Abstract This article emphasises on the results of the master´s thesis “Burials in Bytes. A Quantitative Study of Linear Pottery Cemeteries in Austria, Bohemia, Moravia and Southern Germany” and further elaborates on interpretations of identified patterns at Early Neolithic cemeteries. The focus will lie on the Lower Bavarian site “Aiterhofen-Ödmühle.” Although the cemetery was subject to different analyses and interdisciplinary research in the past, there are still unsolved issues regarding chronology, structure, meaning of the local mortuary rites and rules, and its significance in the superregional context. The study utilised data acquisition via the Montelius image database and quantitative methods performed through the softwares WinSerion and Google Mapper. These data consisted of various typologies and classifications, while several variations of correspondence analysis, seriation, Analysis N Next Neighbours, and the creation of distribution maps have been involved in the process of evaluation. The results of the evaluations of Aiterhofen-Ödmühle favour a chronological south–north progression. Inhumations and cremations differ in grave good equipment, potentially representing contrasts in gender distribution. Spatial groupings are distinguishable through their properties – open to various ways of interpretation and comparable to clusters of other cemeteries. Differences regarding age and sex were also highlighted. Overall, Aiterhofen-Ödmühle stands out among Early Neolithic cemeteries through region-specific grave goods and death gesture, local peculiarities, variation of burial types, and its site structure. Similarities to other sites include characteristic Linear Pottery traits, although less obvious connections can also be recognised through the quantitative evaluations. Instead of rigid funerary rules, dynamic and flexible rites are suggested.
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Guiné, Raquel P. F., Paula M. R. Correia, Cátia Reis, and Sofia G. Florença. "Evaluation of texture in jelly gums incorporating berries and aromatic plants." Open Agriculture 5, no. 1 (2020): 450–61. http://dx.doi.org/10.1515/opag-2020-0043.
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AbstractIn the confectionery market, jelly gums are one of the most relevant sectors, being frequently consumed by many people, from children to adults. The present work intended to evaluate the textural properties in newly developed jelly gums made with berry fruits and herbs, given the critical role of texture in products with a gel-like structure. Four types of gums were developed (Strawberry & Anise, Strawberry & Mint, Raspberry & Mint, Blueberry & Mint) and their texture was evaluated through two types of tests (compression with a 75 mm probe and puncture with a 2 mm probe) allowing to calculate several textural properties. The results showed some differences between the two faces of the jelly gums analysed, i.e. on the top and on the bottom. As for the compression test, the Strawberry & Anise gums were among the softer (25.6 N) and with lower resilience (36.3%) and chewiness (16.9 N), despite being more adhesive (−0.5 N s). As for the puncture test, the sample Strawberry & Mint had the highest adhesiveness (−2.0 N s) but the lowest stickiness (−0.38 N). Additionally, very strong correlations were encountered between some of the properties studied (r = 0.861 or r = 0.822), and the factor analysis allowed defining three factors, the first clearly associated with the puncture properties while the other two were related to the compression properties. This work allowed concluding that the jelly gums presented different textural properties, particularly when assessed through different types of measurements. Hence, the use of different types of tests for texture analysis is recommended, since the results are complementary. This is relevant when developing food products intended for industrial production and commercialization.
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Greco, Christian S., Mohammad Mahdee Sobhanie, Kelci E. Coe, Courtney Hebert, and Margaret Williams. "600. The Effect of Medication-Assisted Treatment on Completion Rates of Outpatient Parenteral Antibiotic Therapy." Open Forum Infectious Diseases 8, Supplement_1 (2021): S403. http://dx.doi.org/10.1093/ofid/ofab466.798.
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Abstract Background Injection drug use is a nationwide epidemic associated with an increased risk of invasive Staphylococcus aureus (S. aureus) infections. Medication-assisted treatment (MAT) is effective in reducing substance use and increasing adherence to inpatient medical therapy in persons with injection drug use (PWID). Studies assessing the impact MAT has on completion of outpatient parenteral antibiotic therapy (OPAT) are limited. Methods This was a single-center, retrospective, cohort study at The Ohio State University Wexner Medical Center in patients admitted from 12/1/2017 to 12/1/2019 with a diagnosis of S. aureus bacteremia who were identified as PWID either by ICD-9 or 10 code or chart review. A formal MAT program was established on 11/30/2018. Patients were assigned to the pre-MAT group if they were discharged prior to 11/30/2018 and to the MAT group with treatment after 11/30/2018. We evaluated a composite outcome of failure to complete OPAT, recurrence of S. aureus bacteremia during the OPAT period and readmission within 30 days. A multivariable logistic regression analysis was performed to examine the association between MAT therapy and the primary composite outcome, while adjusting for proven confounders. Results A total of 700 patients were identified with 644 patients omitted based on exclusion criteria. The study population included 27 in the Pre-MAT group and 17 in the MAT. Median age was 37 years (IQR 30.6 - 46.1). There was a higher number of females in the MAT therapy group compared to the pre-MAT group (82% vs. 33%, p=0.002). Patients in the pre-MAT group had a significantly longer length of stay (25 days vs. 17 days, p=0.01). The primary composite outcome was met if a patient did not complete their OPAT, if they had a recurrence of S. aureus bacteremia during their OPAT or if they were readmitted to the hospital within 30 days. In the pre-MAT group 14/27 (52%) met the composite outcome versus 6/17 (35%) of the MAT group (p=0.28). Conclusion Patients in the MAT group met the composite outcome 17% less than those in the pre-Mat group which is suggestive of the impact MAT has on completion of OPAT therapy; however, this study did not reach statistical significance as it was underpowered. Further longitudinal evaluation with greater sample size is needed to fully evaluate this intervention. Disclosures Mohammad Mahdee Sobhanie, M.D., Regeneron (Scientific Research Study Investigator)Regeneron (Scientific Research Study Investigator, Was a sub-investigator for Regeneron 2066 and 2069)
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Golpour, Iman, Mohammad Kaveh, Reza Amiri Chayjan, and Raquel P. F. Guiné. "Energetic and exergetic analysis of a convective drier: A case study of potato drying process." Open Agriculture 5, no. 1 (2020): 563–72. http://dx.doi.org/10.1515/opag-2020-0058.
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AbstractThis research work focused on the evaluation of energy and exergy in the convective drying of potato slices. Experiments were conducted at four air temperatures (40, 50, 60 and 70°C) and three air velocities (0.5, 1.0 and 1.5 m/s) in a convective dryer, with circulating heated air. Freshly harvested potatoes with initial moisture content (MC) of 79.9% wet basis were used in this research. The influence of temperature and air velocity was investigated in terms of energy and exergy (energy utilization [EU], energy utilization ratio [EUR], exergy losses and exergy efficiency). The calculations for energy and exergy were based on the first and second laws of thermodynamics. Results indicated that EU, EUR and exergy losses decreased along drying time, while exergy efficiency increased. The specific energy consumption (SEC) varied from 1.94 × 105 to 3.14 × 105 kJ/kg. The exergy loss varied in the range of 0.006 to 0.036 kJ/s and the maximum exergy efficiency obtained was 85.85% at 70°C and 0.5 m/s, while minimum exergy efficiency was 57.07% at 40°C and 1.5 m/s. Moreover, the values of exergetic improvement potential (IP) rate changed between 0.0016 and 0.0046 kJ/s and the highest value occurred for drying at 70°C and 1.5 m/s, whereas the lowest value was for 70°C and 0.5 m/s. As a result, this knowledge will allow the optimization of convective dryers, when operating for the drying of this food product or others, as well as choosing the most appropriate operating conditions that cause the reduction of energy consumption, irreversibilities and losses in the industrial convective drying processes.
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Islam, M. Z., F. Begum, M. A. A. Khan, M. Amiruzzaman, and Akbar Hossain. "Evaluation of yield stability of seven barley (Hordeum vulgare L.) genotypes in multiple environments using GGE biplot and AMMI model." Open Agriculture 4, no. 1 (2019): 284–93. http://dx.doi.org/10.1515/opag-2019-0027.
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AbstractEvaluation of genotypes under multiple environments is the prerequisite for the development of stable and superior genotypes for sustainable barley production and a changing climate. GGE (G, genotype and GE, genotype (G) by environment (E), interaction) biplot and the AMMI (The Additive Main effects and Multiplicative Interaction) model are the effective methods to find out the genotype(s) which are stable and suitable to cultivate in specific or multiple environments. The experiment was conducted to analyze the performance of seven barley genotypes for selecting stable and superior genotypes across three different environmental conditions of Bangladesh (i.e., at the Bangladesh Agricultural Research Institute (BARI), Gazipur; at the Regional Agricultural Research Station (RARS), BARI, Jamalpur and at the RARS, BARI Ishurdi). All genotypes in three locations were arranged in a randomized complete block design (RCBD) with three replications. After two years observation, it was found that all genotypes across the location were found highly significant (p≤0.01), due to the variation of environments, genotypic variability and their interaction. The first two principle component axes (PC1 and PC2) of site regression model were significant (P≤0.01) and cumulatively contributed to 89.65% of the total GE interaction. In the polygon view of biplot, there were five rays which divided the biplot into five sectors, and all three locations fell into two of these five sections. Location Jamalpur fell into sector 1, whereas Ishurdi and Gazipur fell into sector 2. Among the locations, Ishurdi was found the best for all genotypes, where Gazipur and Jamalpur were found unfavourable. Among the genotypes, ‘E7’ performed the best for the average grain yield (GY) followed by ‘E3’, ‘E2’ and ‘E4’, whereas ‘E1’ had lowest average GY for all locations. The highest yield in environment Jamalpur was obtained by the genotype ‘E2’, on the other hand genotype ‘E7’ produced the highest GY in locations of Ishurdi and Gazipur. Considering yield stability, genotypes ‘E3’, ‘E4’ and ‘E1’ were found to be more stable, whereas genotype ‘E2’ was the most unstable over all locations. Genotypes ‘E7’ and ‘E3’ were found to be close to the ideal genotype position, in the case of the maximum GY and yield stability across the locations as compared to other genotypes and recommended for commercial cultivation for Bangladesh including South-Asia.
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Komen, Simeon K., Julius O. Ochuodho, and Elmada O. Auma. "Effect of Site and Variety on Yield of Seed Potato in the North Rift Region of Kenya." Open Agriculture 3, no. 1 (2018): 296–300. http://dx.doi.org/10.1515/opag-2018-0032.
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Abstract Potato is Kenya’s second staple food crop, grown by small scale farmers who recycle seed due to unavailability of certified one, resulting in diseases build-up that reduces yields. The subdivision of once seed farms and change of use in the 1980’s effectively limit availability of suitable land for seed production against high demand of quality seed. Hence search for alternative sites in the North Rift for seed production are being explored. However, current varieties in commercial production were not evaluated for their performance in this region. The objectives of the study were to identify suitable potato varieties for seed production and for which elevation in the region.Well sprouted seed tubers of six local varieties were planted at Kitale (1901 m), Kapcherop (2386 m) and Kibigos (2887 m) above sea level following recommended management practices. Plant emergence was slowest at Kibigos while fastest at Kitale. Stem density varied with varieties and attained maximum numbers at 56 days after planting. Most of the varieties had 80% of tubers in seed grade 70 days after planting at Kitale. Introduction of potato varieties should be preceded by evaluation for their performance as some varieties seem more suitable while others do well across the sites for seed production. In cooler areas like Kapcherop and Kibigos potato tubers remain younger, emerge slowly compared to warmer areas, but attain maximum emergence 30 days after planting. Some varieties like Dutch Ronjin, have high number of tubers in seed size category while some have more ware size potatoes grown in same elevation for the same growth period.
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María, B. Gatti, C. Mondino María, M. García Stella, and C. Ciappini María. "Spotting the sensory preferences of artichokes to improve the consumption of this functional food." International Journal of Environmental & Agriculture Research 5, no. 6 (2019): 26–30. https://doi.org/10.5281/zenodo.3264043.
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<strong><em>Abstract -</em></strong> <em>Given the greater varietal supply of the globe artichoke and evaluating its use for human consumption, it is important to carry out market positioning work, including the recognition of the newly available cultivars. Sensory analysis comes up as an important instrument to assess the potential of insertion of artichoke into the market. Within this perspective, the aim of the present study was to determine the sensorial quality characteristics of three globe artichoke cultivars produced in the Rosario´s Horticultural Belt and associated with the preference of consumers. The cultivars were Opal, Madrigal and Romanesco. For sensory evaluation, the method called CATA (Check All That Apply) was used. The results of the CATA test were analyzed using multivariate statistics, applying the Correspondence Analysis. The most distinguishing elements between artichokes were the color and aroma. When associating these results with which was the artichoke that consumers liked the most, it was observed that the Romanesco obtained the best rating. Consumers preferred sweet and tender artichokes. This information could guide the production strategies of the horticulturists to offer cultivars that meet these characteristics.</em>
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Susri Nurhaci, Dian, Agung Setianto, and Wahyu Wilopo. "Analysis and Evaluation of Earthquake Hazard Zones Based on Spatial Models for Regency Regional Development Bantul." IOP Conference Series: Earth and Environmental Science 1373, no. 1 (2024): 012014. http://dx.doi.org/10.1088/1755-1315/1373/1/012014.
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Abstract Earthquakes are a natural disaster that occur frequently in Indonesia. A region susceptible to earthquakes is the Bantul district. Buildings and infrastructure could be damaged by this disaster, especially in highly populated metropolitan areas where the Bantul Regency earthquake (Mw 6.4) on May 27, 2006, resulted in significant damage.The purpose of this research is to identify the distribution of the region’s level of stability against the possibility of an earthquake occurring, as well as the degree of compatibility between the vulnerability zone and the Development Territory Unit (SWP) of Bantul district. This research uses data collection techniques by direct observation with microtremors to calculate surface peak ground acceleration (PGA) with a value of Vs.30. The regional stability weighting matrix approach is used in this study, which is governed by Minister of Public Works Regulation Number 21 of 2007 covering Guidelines for Spatial Planning in Volcanic Eruptions and Earthquake-Prone Areas. The research results for Bantul Regency have a distribution of Vs.30 values between 175 - 350 m/s which is included in the Soft Rock (SC) category with surface peak ground acceleration (PGA) values between 0.112 g - 0.418 g. The final score for Bantul Regency is 20 - 43 which falls into the stable and less stable categories. The Development Area Unit (SWP) of Bantul Regency SWP, which is in the unstable zone, is dominantly distributed around the Opak Fault. SWP II, III, IV, and V require mitigation measures when used for residential areas. Spatial planning that is in accordance with built-up and non-built zones will be able to reduce risk factors.
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Robinson, R., and Z. Kennerley. "Hywel Dda University Health Board antimicrobial pharmacist input into implementation, clinical and outcome monitoring of outpatient parenteral antimicrobial therapy (OPAT)." International Journal of Pharmacy Practice 30, Supplement_2 (2022): ii45. http://dx.doi.org/10.1093/ijpp/riac089.053.
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Abstract Introduction The finance team highlighted an increased spend on antibiotics used by the Acute Response Teams (ART) across Hywel Dda University Health Board (HDUHB). Antimicrobial pharmacists (AMPs) investigated the antibiotics issued to ART and their stock lists. A wide variety of antimicrobials including broad-spectrum, high-cost, and restricted antimicrobials were being prescribed as OPAT. A multi-disciplinary team (MDT) team was set up to implement and deliver good practice recommendations 1alongside providing care closer to home2. Aim To assess the number of patients accessing treatment through the service, evaluate uptake and adherence to OPAT guidelines, identify whether AMPs were having an impact on the service and evaluate patient outcomes. Methods The MDT included consultant microbiologists, AMPs, ART & infection control nurses, consultant anaesthetist and orthogeriatrician. A Standard Operating Procedure and guidelines were implemented. A data collection form was completed by nurses for each patient and monitored by AMPs. The data underwent descriptive statistical analysis. Ethical approval was not required for this service evaluation. Results The service saved 1685 bed days across two counties (Ceredigion and Carmarthenshire) over a 6-month period. Patients were treated with a variety of antimicrobial agents including ceftriaxone, ertapenem, teicoplanin and ceftazidime. Patients receiving OPAT received a clinical check by an AMP for clinical appropriateness, therapeutic drug monitoring and dosing according to blood results. AMPs undertook over 200 reviews, making 27 interventions, including advice on monitoring, when to take levels, bloods, or antibiotic choice. There were only 6 interventions on choice of antibiotic to include more stewardship wise options or options for reduced dosing frequency to increase the capacity of ART, highlighting good uptake and adherence to the guidelines. Outcome forms were collected for all 31 patients in Ceredigion 81% (26 patients) were cured of their infection. In 6% the treatment aim was not attained and required readmission, 6% had no information supplied, 3% were reviewed in clinic and switched to oral and 3% required readmission due to unrelated event. Discussion/Conclusion Collaboration within the MDT has led to an improvement in practice while delivering OPAT in HDUHB. Development of a working relationship between the ART nurses and AMPs has led to improved patient safety and monitoring whilst offering patients the opportunity to receive care closer to home. The availability of AMPs to provide answers and guidance in a timely manner to ART has made treatment in the community easier and safer. The guidelines launched at the beginning of the COVID-19 pandemic in an effort to reduce the number of patients occupying beds in secondary care however, this led to a reduced ability for education to be delivered on the guidelines compared to normal practice. Further work is needed to involve the Pembrokeshire team in the process and to increase awareness of the guidelines in both primary and secondary care. Discussions are also in place to investigate whether elastomeric devices offer better antimicrobial stewardship wise treatment options. The main limitation of this study is the inability to follow up long term outcomes. References 1. Chapman A., Patel S., Horner C., Gilchrist M. and Seaton A. Outpatient parenteral antimicrobial therapy: updated recommendations from the UK. Journal of Antimicrobial Chemotherapy, Volume 74, Issue 11, November 2019, Pages 3125–3127, https://doi.org/10.1093/jac/dkz343 2. Welsh Government. A Healthier Wales: our Plan for Health and Social Care. 2021 A Healthier Wales (gov.wales)
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Yagnik, Kruti J., Hala Saad, Cylaina Bird, et al. "124. Implementation of IV Push Antibiotics for Outpatients During a National Fluid Shortage Following Hurricane Maria." Open Forum Infectious Diseases 8, Supplement_1 (2021): S175. http://dx.doi.org/10.1093/ofid/ofab466.326.
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Abstract Background Prior to the introduction of intravenous (IV) drip infusion, most IV drugs were delivered in a single bolus. However, with the advent of new agents, IV drip infusions became the standard for all medication delivery. In September 2017, Hurricane Maria made landfall in Puerto Rico and took a devastating toll. As Puerto Rico is the largest supplier of IV fluid bags, this lead to a worldwide fluid bag shortage. The outpatient antimicrobial therapy program (OPAT) was significantly impacted by the fluid shortage and this required effective stewardship at the Parkland Health and Hospital System in order to serve a largely uninsured and under-insured patient population. Methods Parkland pharmacists evaluated all self-administered antimicrobials for viability of administration as an IV single bolus push (IV-push) instead of a mini-bag infusion (IV-drip infusion). These medications were transitioned to IV-push for patient care. Data was gathered on patient demographics, 30-day readmission rates, mortality, discharge teaching satisfaction, patient satisfaction, and cost evaluation. Results 113 treatment courses were self-administered using the IV-push method and were compared to 102 self-administered courses using the IV drip infusion method, over the same time course. Individuals using IV-push had a statistically significant decrease in hospital length of stay as compared to those using IV-drip infusion. The 30-day readmission rate, emergency department visits, and mortality were similar between groups. Patient satisfaction was greater with IV-push (96% preferring). The shift to IV-push via the S-OPAT program saved 504 liters of normal saline, which along with a reduction in supplies and drug costs, resulted in an additional savings of &43,652 over a 6-month period. Conclusion The abrupt IV fluid shortage following a natural disaster challenged clinicians to think differently about standard practices. This led to implementation of a high value care model that is sustainable without affecting safety, efficacy, or efficiency. Given the cost savings, increased patient satisfaction, and equal clinical outcomes, the IV push model is not only a viable alternative initiated during a crisis; it is preferable in many standard situations. Disclosures All Authors: No reported disclosures
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Denisova, Svetlana, and Antonina Reut. "Evaluation of the varieties of Chrysanthemum × hortorum from the collection SUBGI UFRC RAS taking into account the direction of use." Agrarian Bulletin of the 207, no. 04 (2021): 64–73. http://dx.doi.org/10.32417/1997-4868-2021-207-04-64-73.
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Abstract. Chrysanthemum × hortorum Bailey is a perennial plant of the Compositae family. Perhaps the most famous and demanded late-flowering culture, which is used both for landscaping the private sector and in the green construction of settlements. However, its use in the soil and climatic conditions of the Bashkir Ural is difficult due to the lack of varieties adapted to local conditions and a reasonable assortment. The aim of the study was a comprehensive assessment of varieties of chrysanthemum from the collection of the South-Ural Botanical Garden of Ufa, taking into account the directions of use. Methods. In accordance with the methodology of E. S. Pidgainaya and other authors plants went through two stages of analysis: at the first stage, the most decorative and stable varieties were identified; on the second, the perspective direction of use of each of them was determined. At the first stage, decorative (decorativeness of a bush, leaves, inflorescences; aroma; variety uniformity; abundance of flowering) and economically valuable (productivity and flowering duration; drought resistance; winter hardiness; resistance to adverse conditions, diseases and pests; intensity of vegetative reproduction) signs were assessed. Results. As a result of the analysis of the decorative qualities of 112 varieties of chrysanthemum, ten were identified (Aktanysh, Anyuta, Belosnezhka, Vecherniye Ogni, Opal, Pektoral, Rozovaya Mechta, Solnechnaya Feyeriya, Solnyshko, Ufimskaya Yubileynaya), which have a high decorative effect of the bush, a weak aroma and are characterized by abundant flowering; they are rated 49–50 points. 84 varieties are rated 40–48 points, they have less abundant flowering and a stronger aroma. According to economically valuable traits, the highest number of points (48–49) was awarded to 4 varieties (Aktanysh, Nezhnaya Muza, Akiwa Yellow, Kurochka Ryaba). The lowest total score (34) belongs to the variety Golden Dukat. As a result of the comprehensive assessment, 106 varieties were classified as highly promising, they scored more than 80 points; six varieties are promising, they are estimated at 60–80 points. Scientific novelty. At the second stage of the analysis, when determining a promising direction of use, it was revealed that most varieties (88) can be recommended for garden use and 25 for container crops.
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El, Sayed A.A., Tammam H.M.H MD, and Abdel kader E.F MD. "Accuracy of rush protocol in diagnosis of septic shock." Biolife 3, no. 4 (2022): 900–904. https://doi.org/10.5281/zenodo.7309335.
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<strong>ABSTRACT</strong> <strong>Background:</strong> Rapid ultrasound in shock (RUSH) is the most recent emergency ultrasound protocol, designed to help clinicians better recognize distinctive shock etiologies in a shorter time frame. Objectives: In this study, we evaluated the accuracy of the RUSH protocol in predicting septic shock among shocked patients. <strong>Patients and Methods:</strong> RUSH protocol was performed over all patients suspected having septic shock. All patients were closely followed to determine their final clinical diagnosis. Sensitivity, specificity, positive predictive value (PPV) , negative predictive value (NPV) and accuracy of RUSH for diagnosis of septic shock were calculated. <strong>Results:</strong> We performed RUSH protocol on 168 patients. Its accuracy for septic shock diagnosis is 77.27%,its sensitivity was 74.55%,its specificity was 84.09%,its positive predictive value was 92.13% and its negative predictive value was 56.92%. <strong>Conclusion:</strong> This study highlights the role of the RUSH exam performed by an emergency physician, to make a rapid and reliable diagnosis of shock etiology, especially in order to rule out obstructive, cardiogenic and hypovolemic shock types in initial exam of shock patients. <strong>Keywords:</strong> Emergency; Ultrasound; Shock,septic shock. <strong>REFERENCES</strong> Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Critical care medicine. 2007;35(5):1244-50. Epub 2007/04/07. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine. 2001;29(7):1303-10. Epub 2001/07/11. Rose JS, Bair AE, Mandavia D, Kinser DJ. The UHP ultrasound protocol: Anovel ultrasound approach to the empiric evaluation of the undifferentiated hypotensive patient. Am J Emerg Med 2001;19:299-302. Atkinson PR, McAuley DJ, Kendall RJ, Abeyakoon O, Reid CG, Connolly J, et al. Abdominal and cardiac evaluation with sonography in shock (ACES): An approach by emergency physicians for the use of ultrasound in patients with undifferentiated hypotension. Emerg Med J 2009;26:87-91. Perera P, Mailhot T, Riley D, Mandavia D. The RUSH exam: Rapid ultrasound in shock in the evaluation of critically ill patient. Emerg Med Clin North Am 2010;28:29-56. Perera P, Mailhot T, Riley D, Mandavia D. The RUSH Exam 2012: Rapid ultrasound in shock in the evaluation of critically ill patient. Ultrasound Clin 2012;7:255-78. Joseph M, Disney P. Transthoracic echocardiog-raphy to identify or exclude cardiac cause of shock. Chest 2004;126:1592–7. Bealieu Y. Specific skill set and goals of focused echocardiography for critical care physicians. CritCare Med 2007;35:S144–9. Grifoni S, Olivotto I, Cecchini P, et al. Utility of an integrated clinical, echocardio- graphic and venous ultrasound approach for triage of patients with suspected pulmonary embolism. Am J Cardiol 1998;82:1230–5. Jardin F, Veillard-Baron A. Ultrasonographic examination of the vena cavae. Intensive Care Med2006;32:203–6. Marik PA. Techniques for assessment of intravas-cular volume in critically ill patients. J Int CareMed 2009;24(5):329–37. Blehar DJ, Dickman E, Gaspari R. Identification of congestive hear t failure via respiratory variation of inferior vena cava. Am J Em Med 2009;27:71–5. Nagdev AD, Merchant RC, Tirado-Gonzalez A,et al. Emergency department bedside ultrasono-graphic measurement of the caval index for nonin-vasive determination of low central venous pressure. Ann Emerg Med 2010;55:290–5. Schefold JC, Stor m C, Bercker S, et al. Inferior vena cava diameter correlates with invasive hemo-dynamic measures in mechanically ventilated intensive care patients with sepsis. J Emerg Med2010;38(5):632–7. Jang T, Aubin C, Naunheim R, et al. Ultrasonog-raphy of the internal jugular vein in patients with dyspnea without jugular venous distention on phys-ical examination. Ann Emerg Med 2004;44:160–8. Simon MA, Kliner DE, Girod JP, et al. Detection of elevated right atrial pressure using a simple bedside ultrasound measure. Am Heart Journ2010;159:421–7. Connolly JP. Hemodynamic measurements during a tension pneumothorax. Crit Care Med 1993;21:294–6. Carvalho P, Hilderbrandt J, Charan NB. Changes in bronchial and pulmonar y ar terial blood flow with Perera et al274progressive tension pneumothorax. J Appl Physiol 1996;81:1664–9. Volpicelli G, Caramello V, Cardinale L, et al.Bedside ultrasound of the lung for the monitoring of acute decompensated heart failure. Am J EmMed 2008;26:585–91. Lichtenstein D. Ultrasound examination of the lungs in the ICU. Pediatr Crit Care 2009;10(6):693–8. Lensing AW, Prandoni P, Brandjes D, et al. Detec-tion of deep vein thrombosis by real time B-mode ultrasonography. N Engl J Med 1989;320:342–5. B irdwe l l B G, R as ko b GE, Whi t se tt TL, e t al . The c li nic al va l idi ty of n or ma l co mpres sio n ul tr as o-n ogr a phy in o utp at ie nts su sp ec ted of h av in gde ep ve no us th rombo si s. An n Int er n Me d 199 8 ;1 28: 1 –7 . Farahmand S, Farnia M, Shahriaran S, et al. The accuracy of limited B-mode compression tech-nique in diagnosing deep venous thrombosis in lower extremities. Am J Emerg Med 2011;29(6):687–90. Ghane MR, Gharib M, Ebrahimi A, Saeedi M, Akbari-Kamrani M, Rezaee M, Rasouli H. Accuracy of early rapid ultrasound in shock (RUSH) examination performed by emergency physician for diagnosis of shock etiology in critically ill patients. J Emerg Trauma Shock 2015;8:5-10. Shahram Bagheri -Hariri & Meysam Yekesadat & Shervin Farahmand &Mona Arbab & Mojtaba Sedaghat & Neda Shahlafar & Alireza Takzare &Seyedhossein Seyedhossieni-Davarani & Amir Nejati, The impact of using RUSH protocol for diagnosing the type of unknown shock in the emergency department. Emergency Radiology2015;22(3).DOI:10.1007/s10140-014-1279-0). Volpicelli G, Lamorte A, Tullio M, Cardinale L, Giraudo M, Stefanone V, et al. Point-of-care multiorgan ultrasonography for the evaluation of undifferentiated hypotension in the emergency department. Intensive Care Med 2013;39:1290-8. Opal SM, Cross AS. Clinical trials for severe sepsis: Past failures and future hopes. Infect Dis Clin North Am 1999;13:285-97. King EG, Bauza GJ, Mella JR, Remick DG. Pathophysiologic mechanisms in septic shock. Lab Invest 2014;94:4-12
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Leung, Y. Y., R. Holland, A. Mathew, et al. "AB0794 CLINICAL TRIAL DISCRIMINATION OF PHYSICAL FUNCTION INSTRUMENTS FOR PSORIATIC ARTHRITIS: A SYSTEMATIC REVIEW." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1696.2–1697. http://dx.doi.org/10.1136/annrheumdis-2020-eular.883.
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Background:Physical function is a core domain to be measured in randomized controlled trials (RCTs) of psoriatic arthritis (PsA). The discriminative performance of patient reported outcome measures (PROMs) for physical function (PF) in RCTs has not been evaluated systematically.Objectives:In this systematic review, the GRAPPA-OMERACT working group aimed to evaluate the clinical trial discrimination of PF-PROMs in PsA RCTs.Methods:We searched PubMed and Scopus databases in English to identify all original RCTs conducted in PsA. We limited the review to RCTs of biologic and targeted synthetic DMARDs. Groups of two researchers extracted data independently for PF-PROMs. We assessed quality in each article using the OMERACT good method checklist. Effect sizes (ES) for the PF-PROMs were calculated and appraised usinga priorihypotheses. Evidence supporting clinical trial discrimination for each PF-PROM was summarized to derive recommendations.Results:32 articles were included (Figure 1). Four PF-PROMs had data for evaluation: HAQ-Disability Index (DI), HAQ-Spondyloarthritis (S), Short Form 36-item Health Survey Physical Component Summary (SF-36 PCS), and the Physical Functioning domain (SF-36 PF) (Table 1). The ES for intervention versus (vs.) control arms for HAQ-DI ranged from -0.55 to -1.81 vs. 0.24 to -0.52; and for SF-36 PCS ranged from 0.30 to 1.86 vs. -0.02 to 0.63.Table 1.Summary of Measurement Properties Table for clinical trial discriminationArticlesHAQ-DIHAQ-SSF-36 PCSSF-36 PFAntoni 2005 (IMPACT); Gottlieb 2009 (UST)+Antoni 2005 (IMPACT2)++Kavanaugh 2006 (IMPACT2)+Mease 2005 (ADEPT); Genovese 2007 (ADA); Mease 2010 (ETN); Kavanaugh 2009 (GO-REVEAL); Kavanaugh 2017 (GO-VIBRANT); Gladman 2014 (RAPID-PsA); Mease 2015 (FUTURE1); McInnes 2015 (FUTURE2); Kavanaugh, 2016 (FUTURE2)-subgroup; Nash 2018 (FUTURE3); Mease 2017 (SPIRIT-P1); Nash 2017 (SPIRIT-P2); Deodhar 2018 (GUS); Mease 2016 (CLZ)++Mease 2000 (ETN); McInne, 2013 (PSUMMIT 1); Ritchlin 2014 (PSUMMIT 2); Araugo 2019 (ECLIPSA)++Gniadecki 2012 (PRESTA)+Mease 2019 (SEAM-PsA)+/-+McInnes 2014 (SEC)++Mease 2014 (BRO)++Mease 2011 (ABT)+/-+Mease 2017 (ASTRAEA)++Mease 2006 (ALC)+/-Mease 2017 (OPAL Broaden); Gladman 2017 (OPAL Beyond)++Mease 2018 (EQUATOR)++Mease 2018 (ABT-122)+Total available articles311244Total articles for evidence synthesis291232Overall rating+++Color code in each box indicate study quality by OMERACT good methods. GREEN: “likely low risk of bias”; AMBER: “some cautions but can be used as evidence”; RED: “don’t use as evidence”. WHITE (empty boxes): absence of information from that study. (+): findings had adequate performance of the instrument; (+/-): equivocal performance; (-): poor performance (less than adequate).Conclusion:Clinical trial discrimination was supported for HAQ-DI and SF-36 PCS in PsA with low risk of bias; and for SF-36 PF with some caution. More studies are required for HAQ-S.Disclosure of Interests:Ying Ying Leung Speakers bureau: Novartis, Janssen, Eli Lilly, Richard Holland: None declared, Ashish Mathew: None declared, Christine Lindsay Employee of: Previously employed (worked) for pharmaceutical company., Niti Goel Shareholder of: UCB and Galapagos, Consultant of: VielaBio, Mallinckrodt, and IMMVention, Alexis Ogdie Grant/research support from: Novartis, Pfizer – grant/research support, Consultant of: AbbVie, BMS, Eli Lilly, Novartis, Pfizer, Takeda – consultant, Ana-Maria Orbai Grant/research support from: Abbvie, Eli Lilly and Company, Celgene, Novartis, Janssen, Horizon, Consultant of: Eli Lilly; Janssen; Novartis; Pfizer; UCB. Ana-Maria Orbai was a private consultant or advisor for Sun Pharmaceutical Industries, Inc, not in her capacity as a Johns Hopkins faculty member and was not compensated for this service., Pil Hoejgaard: None declared, Jeffrey Chau: None declared, Laura C Coates: None declared, Vibeke Strand: None declared, Dafna D Gladman Grant/research support from: AbbVie, Amgen Inc., BMS, Celgene Corporation, Janssen, Novartis, Pfizer, UCB – grant/research support, Consultant of: AbbVie, Amgen Inc., BMS, Celgene Corporation, Janssen, Novartis, Pfizer, UCB – consultant, Robin Christensen: None declared, William Tillett: None declared, Philip J Mease Grant/research support from: Abbott, Amgen, Biogen Idec, BMS, Celgene Corporation, Eli Lilly, Novartis, Pfizer, Sun Pharmaceutical, UCB – grant/research support, Consultant of: Abbott, Amgen, Biogen Idec, BMS, Celgene Corporation, Eli Lilly, Novartis, Pfizer, Sun Pharmaceutical, UCB – consultant, Speakers bureau: Abbott, Amgen, Biogen Idec, BMS, Eli Lilly, Genentech, Janssen, Pfizer, UCB – speakers bureau
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Dra., Airelys Campos Herrera. "Evaluación del OPAC´s de la "Biblioteca Zoe y Pablo de la Torriente Brau" de la Facultad de Comunicación de la Universidad de La Habana: sus fortalezas y debilidades." Alcance 8, no. 19 (2018). https://doi.org/10.5281/zenodo.4539570.
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El presente artículo tiene como objetivo evaluar el catálogo en línea de la biblioteca “Zoe y Pablo de la Torriente Brau” de la Facultad de Comunicación de la Universidad de La Habana, detectando fortalezas y debilidades del mismo. Se analizan iniciativas, metodologías y herramientas de evaluación de OPAC´s y se determina la herramienta a aplicar en el estudio. Se reconocen sus principales características y se construye un instrumento de recopilación de información en correspondencia con la herramienta seleccionada. Se presentan las debilidades y fortalezas del OPAC´s de la biblioteca “Zoe y Pablo de la Torriente Brau” de la Facultad de Comunicación de la Universidad de La Habana.
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Saqar, Alotaibi. "Users evaluation of FRBR prototype system: a comparative study between Worldcat and Umm Al-Quras online catalogue in identifying works on Islam." January 1, 2010. https://doi.org/10.5281/zenodo.6390942.
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This study explored user experiences in using Worldcat FRBR-based OPAC and Umm Al-Qura University OPAC with regard to works on Islam. FRBR with its permissible in element relationship might enhance the relationship with bibliographic records. User studies have been considered as essential in conducting this study in order to find out their experiences and perceptions to both systems. The study was concerned with four user tasks which are find, select, identify and obtain or acquire. The study allowed student to be involved in performing four tasks in searching for original work, author, editions and translated copies. The population of the study comprised of all undergraduate students of the Library and Information Science Department in Umm Al-Qura University, Saudi Arabia. The survey research method was employed to conduct the research and students were also asked to express their opinions and perceptions. Descriptive Statistic method was employed for the analysis of the data collected. This research found that respondents experienced difficulties in meeting the four user tasks while using Umm Al-Qura’s online catalogue. However, they were impressed with the Worldcat and it was their first time using it. Hence, respondents preferred to have the same system in their library. It was also found that the Worldcat FRBR prototype system supports the user tasks; “find, identify, select and obtain” better than the regular online catalogue. The study also discovered perceived ease of use and perceived helpfulness of the Worldcat FRBR-based OPAC and the use of colour and design were among the factors contributing in users’ differences …
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Slain, Nicole, Ryan P. Mynatt, Kathryn Ruf, et al. "P-1893. Evaluation of Infectious Disease Consultation on Outpatient Antimicrobial Therapy (OPAT) Referral Volume and Outcomes." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.2054.
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Abstract Background Institutional experience with OPAT is increasingly reported. However, little is known about the referral process across the continuum of care and its impact on OPAT volume and patient outcomes. The purpose of this study is to characterize OPAT referral trends from a multi-service line infectious diseases (ID) group and its impact on end of therapy patient outcomes. Methods This retrospective analysis included adult patients referred to the OPAT program from either of the two system hospitals and seen by any of the five inpatient consult teams or the ambulatory ID clinic between June 2021 and July 2022. Patients were identified via a data extraction from the electronic health record by the institution’s Healthcare Analytics Team or Center for Clinical and Translational Sciences. OPAT patients were identified via the OPAT Electronic Data Capture (REDCap) database. Results A total of 3738 ID consult orders were placed on 2708 patients, dispersed between four consult teams at hospital 1 (Table 1). The OPAT program received 1504 referrals, 1475 (98.1%) inpatient referrals and 29 (1.9%) outpatient. A total of 914 patients were discharged to receive IV antimicrobials, 723 (78.2%) and 191 (32.9%) (p &lt; 0.00001), for standard OPAT (S-OPAT) and modified OPAT (M-OPAT), respectively (Figure 1). End of therapy outcomes were recorded on 798 (87.3%) patients. The Transplant service had the highest percentage of referrals eligible for S-OPAT (90%); however, it also saw the highest 60-day readmission rate (36.2%) (Table 1). There was no statistically significant difference (p = 0.281) in proportion of referrals with end of treatment failure within the ID services at hospital 1. However, therapy extension was more frequent in the Bone and Joint and General ID teams (p &lt; 0.001). Hospital 2 had more patients that were unable to complete their antimicrobial therapy (14.6%) (Table 3). Conclusion Our analysis of patients seen by ID consult services demonstrated a significant portion were ultimately referred for OPAT. Differences in referral rates were noted between service lines, along with differences in 30 and 60-day readmission rates. Overall, end of therapy and clinical outcomes were fairly similar throughout the groups. Disclosures Alisha Clemons, APRN, Gilead Sciences: Honoraria
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Lanotte, Francesco, Sung Yul Shin, Megan K. O'Brien, and Arun Jayaraman. "Validity and reliability of a commercial wearable sensor system for measuring spatiotemporal gait parameters in a post-stroke population: the effects of walking speed and asymmetry." Physiological Measurement, August 9, 2023. http://dx.doi.org/10.1088/1361-6579/aceecf.
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Abstract Objective. Commercial wearable sensor systems are a promising alternative to costly laboratory equipment for clinical gait evaluation, but their accuracy for individuals with gait impairments is not well established. Therefore, we investigated the validity and reliability of the APDM Opal wearable sensors system to measure spatiotemporal gait parameters for healthy controls and individuals with chronic stroke. Approach. Participants completed the 10-meter walk test over an instrumented mat three times in different speed conditions. We compared performance of Opal sensors to the mat across different walking speeds and levels of step length asymmetry in the two groups. Main results. Gait speed and stride length measures achieved excellent reliability, though they were systematically underestimated by 0.11 m/s and 0.12 m, respectively. The stride and step time measures also achieved excellent reliability, with no significant errors (median absolute percentage error<6.00% s, p>0.05). The measures of gait phase durations achieved moderate-to-excellent reliability, with relative errors ranging from 4.13–21.59%. Across gait parameters, the relative error decreased by 0.57–9.66% when walking faster than 1.30 m/s; similar reductions occurred for step length symmetry indices lower than 0.10. Significance. This study supports the use of Opal wearable sensors to obtain quantitative measures of post-stroke gait impairment, while recommending cautious interpretation of these measures for individuals with moderate-severe asymmetry or walking speeds slower than 0.80 m/s.
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Bhagat, Hita, Monica K. Sikka, Ellie S. Sukerman, Jina Makadia, James S. Lewis, and Amber C. Streifel. "Evaluation of Opportunities for Oral Antibiotic Therapy in Bone and Joint Infections." Annals of Pharmacotherapy, June 3, 2022, 106002802211011. http://dx.doi.org/10.1177/10600280221101105.
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Background: The OVIVA trial suggests oral antibiotics are an alternative to intravenous antibiotics to treat bone and joint infections (BJI). A shift in practice to treatment with oral antibiotics would eliminate the need for central vascular access, improve patient satisfaction, and reduce overall healthcare costs. Objective: The primary objective was to identify the proportion of patients treated for BJIs with outpatient parenteral antimicrobial therapy (OPAT) who would have qualified for oral antibiotics based on microbiological data. The secondary objective was to conduct a cost-analysis to estimate potential cost-savings had eligible patients been treated with oral antibiotics. Methods: This was a single-center, retrospective study of adult patients in the United States treated with intravenous antibiotics for BJIs from January 2018 to April 2020. Inclusion and exclusion criteria matched the OVIVA trial. Patients with Staphylococcus aureus bacteremia, endocarditis, or other high-risk features were excluded. Results: 281 patients met the inclusion criteria. Most had prosthetic joint infections (56%). Infections caused by coagulase-negative staphylococci (25%) were most common, followed by S. aureus (23%) and polymicrobial infections (22%). 69 (25%) patients required a switch during their OPAT course to an alternate antibiotic agent. Thirteen patients (5%) experienced vascular access complications, and 6 patients (2%) developed Clostridiodes difficile infections. Oral therapy could have resulted in an estimated average savings per patient of $3,270.69 USD. Conclusion and Relevance: Most patients treated with OPAT for BJIs were candidates for oral antibiotics. A change in practice would result in cost-savings to the U.S. healthcare system.
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Mendes, Tiago P., Josimar A. da Silva, Felipe V. R. Avelar, Edvaldo F. dos Reis, Paulo C. Cavatte, and Fábio L. de Oliveira. "Physiological activities and yield of yacon potato are affected by soil water availability." Open Agriculture 10, no. 1 (2025). https://doi.org/10.1515/opag-2025-0432.
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Abstract The commercial cultivation of yacon is relatively new, creating several knowledge demands regarding its agricultural management, including water relations. Thus, the aim of this study is to understand the effects of different soil water availability levels on the physiological activities of yacon. The first experiment aimed to establish the survival limit of the plants under water deficit, while the second aimed to determine the range for optimal development within a smaller range of water availability. A completely randomized design was adopted, with four replications and five treatments (soil water tension levels). The first experiment used tensions of 30, 60, 100, 200, and 300 kPa, while the second used tensions of 20, 30, 45, 60, and 75 kPa. Evaluations included net CO2 assimilation rate, stomatal conductance, transpiration rate, intercellular CO2 concentration, chlorophyll indices, nitrogen balance, anthocyanin, and flavonoid content. The yacon’s survival limit under water deficit occurred at 200 kPa, when the plant reached the lowest assimilation rate (11.607 µmol CO2 m−2 s−1), representing a 57.53% reduction in its photosynthetic capacity before dying under the 300 kPa tension. From 100 kPa tension, flavonoid production increased, indicating that yacon plants activated defense mechanisms to mitigate the effects of water stress. The highest photosynthetic rates in yacon were observed under higher water availability (lower tension, 20 kPa), close to the soil’s field capacity (10 kPa). In the first experiment, significant tuberous root production was observed only at 30 kPa, yielding approximately 1,100 g plant−1. In the other treatments, fresh tuberous root production was around 100 g plant−1, but without meeting commercial standards (small and very thin roots). In the second experiment, a linear decrease in production was observed as soil water availability declined. Overall, the production ranged from 1156.3 to 135.2 g plant−1, between the highest and lowest water availability levels applied (tensions of 20 and 75 kPa, respectively), with a 16.05% reduction in yield for every 10 kPa increase in soil water tension. This result has the practical implication of demonstrating that yacon potato exhibits better physiological performance, and therefore the potential for higher productivity, when soil water availability is close to field capacity. This is a fundamental and guiding piece of information for irrigation management in yacon cultivation.
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BRANCO, LUIS MANUEL, ENDAH RETNO PALUPI, SATRIYAS ILYAS, BAMBANG SAPTA PURWOKO, and AGUS PURWITO. "Evaluation of agro-morphological and molecular characters of 22 rice landraces of East Timor." Biodiversitas Journal of Biological Diversity 24, no. 5 (2023). http://dx.doi.org/10.13057/biodiv/d240505.
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Abstract. Branco LM, Palupi ER, Ilyas S, Purwoko BS, Purwito A. 2023. Evaluation of agro-morphological and molecular characters of 22 rice landraces of East Timor. Biodiversitas 24: 2536-2546. Landraces play an important role in the local food security and sustainable development of agriculture as a source of genes that control important traits adaptive to environmental conditions. The study aimed to characterize the agro-morphological and molecular characteristics of 22 rice landraces of East Timor (Timor Leste). The research was conducted in April-August 2018 in Caibada-Baucau-East Timor. Soil analysis was conducted at the Soil Laboratory of the Agronomy and Horticulture Department, IPB University. Materials used were 22 rice landraces seeds and one check variety. The seeds were germinated in seedbed seedlings with a basin (30 cm x 25 cm). The seedlings were planted in the field 16 days after sowing in a plot of 1.5 m x 7.0 m and a spacing of 25 cm x 25 cm, with an isolation distance between plots of ±3 m. Data collection was based on nine growth phases of rice. The cluster analysis based on agro-morphological characters resulted in 6 groups with a similarity coefficient of 0.17 or 17%, showing a high level of diversity. The lowest yield was Ale Kukefuhu (290 g/m2), and the highest was Hare Nona Portu (979 g/m2). Using 10 RAPD markers, the 22 rice landraces samples produced 77 DNA fragment bands with sizes between 300 bp-1475 bp, averaging 3.35 alleles per landrace; polymorphic rates of 8.1. OPA8, OPH1, and OPH7 markers were the highest (100.00%), and OPF5 was the lowest (66.67%) polymorphic percentage. Based on the molecular marker, the coefficient of similarity of the landraces ranged from 0.12 to 0.51, and they were grouped into five clusters.
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Sime, Fekade B., Steven C. Wallis, Conor Jamieson, et al. "P15 Evaluation of the stability of temocillin in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy in accordance with the requirements of the UK NHS Yellow Cover Document." JAC-Antimicrobial Resistance 4, Supplement_1 (2022). http://dx.doi.org/10.1093/jacamr/dlac004.014.
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Abstract Background To assess the feasibility of its use in OPAT via continuous infusion, the stability of temocillin solutions at clinically relevant concentrations in two elastomeric infusion devices (B. Braun Medical Ltd Easypump® II LT 270-27- S and Spirit Ltd Medical Dosi-Fuser® L25915-250D1) was evaluated during 14 days of (2°C–8°C) fridge storage followed by 24 h exposure in-use temperature at 32°C, when reconstituted with 0.3% citrate buffer at pH 7. Methods Stability testing was conducted in accordance with the standard protocols for deriving and assessment of stability of small molecule aseptic preparation as per the latest UK National Health Service Pharmaceutical Quality Assurance Committee Yellow Cover Document (YCD) requirements. A stability indicating assay method was developed with an ultra-HPLC (UHPLC) system using photodiode array detector. Temocillin concentrations corresponding to low (500 mg/240 mL), intermediate (4000 mg/240 mL) and high (6000 mg/240 mL) dose in triplicate devices were tested with duplicate samples at 11 timepoints during 14 days of fridge storage followed by 24 h in-use temperature exposure at 32°C. Results A total of 396 samples were collected and assayed. The percentage of temocillin remaining after 14 days of fridge storage was greater than 97% in both devices and at all concentrations tested. During in-use temperature, 95% stability limit was achieved for 12 h for all doses and devices tested except for the high concentration in the Dosi-Fuser® device, which met this criterion for only 10 h of in-use temperature exposure. Conclusions Temocillin reconstituted with 0.3% citrate buffer at pH 7 in elastomeric infusion devices can be stored in a fridge (2°C–8°C) for 2 weeks, meeting the YCD acceptance criteria of &lt;5% degradation. Within the UK, the current data supports twice daily dosing of temocillin with &lt;5% degradation at in-use temperature of 32°C for 12 h, except at high dose (6000 mg/240 mL) in the Dosi-Fuser® device, which must be limited to 10 h. The limits of accepted degradation do vary in other countries. Temocillin is an important addition to the anti-Gram-negative OPAT armamentarium and may reduce reliance on other broader spectrum, higher consequence agents.
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Szumińska, Danuta, Tomasz Giętkowski, and Sebastian Czapiewski. "Ocena zmiany warunków hydrologicznych na terenach zurbanizowanych z wykorzystaniem technik GIS = GIS-based assessment of changes related to hydrological conditions in urban areas." May 11, 2015. https://doi.org/10.5281/zenodo.17494.
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<strong>Szumińska Danuta, Giętkowski Tomasz, Czapiewski Sebastian. Ocena zmiany warunków hydrologicznych na terenach zurbanizowanych z wykorzystaniem technik GIS = GIS-based assessment of changes related to hydrological conditions in urban areas. </strong><strong>Journal</strong> <strong>of</strong> <strong>Education</strong><strong>, </strong><strong>Health</strong> <strong>and</strong> <strong>Sport</strong><strong>. </strong><strong>2015;5(5):</strong><strong>173-182</strong><strong>. </strong><strong>ISSN</strong><strong> 2391-8306</strong><strong>. </strong><strong>DOI</strong> <strong>10.5281/zenodo.17494</strong> <strong>http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%285%29%3A173-182</strong> <strong>https://pbn.nauka.gov.pl/works/559397</strong> <strong>http://dx.doi.org/10.5281/zenodo.17494</strong> <strong>Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 </strong><strong>http://journal.rsw.edu.pl/index.php/JHS/issue/archive</strong> <strong>Deklaracja.</strong> <strong>Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.</strong> <strong>Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.</strong> <strong>The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).</strong> <strong>© The Author (s) 2015;</strong> <strong>This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland</strong> <strong>Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,</strong> <strong>provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License</strong> <strong>(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial</strong> <strong>use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>The authors declare that there is no conflict of interests regarding the publication of this paper.</strong> <strong>Received: 15.02.2015. Revised 27.04.2015. Accepted: 08.05.2015.</strong> <strong>Ocena zmiany warunków hydrologicznych</strong> <strong>na terenach zurbanizowanych z wykorzystaniem technik GIS</strong> <strong>GIS-based assessment of changes related to hydrological conditions in urban areas</strong> <strong>Danuta Szumińska<sup>1</sup>, Tomasz Giętkowski, Sebastian Czapiewski</strong> <strong>Wydział Kultury Fizycznej, Zdrowia i Turystyki,</strong> <strong>Uniwersytet Kazimierza Wielkiego w Bydgoszczy</strong> <strong>email: dszum@ukw.edu.pl<sup>1</sup></strong> <strong>Streszczenie</strong> W artykule zaprezentowano możliwości wykorzystania technik GIS do przeprowadzenia analizy zmiany warunków hydrologicznych. Badania przeprowadzono na terenie zurbanizowanym, na którym dokonano zmian rzeźby oraz sposobu użytkowania terenu. Spowodowało to pojawieniem się problemów z odwodnieniem terenu, przede wszystkim w czasie wzmożonego zasilania z opadów deszczu i roztopów śniegu. W celu określenia przyczyn występujących problemów porównano rzeźbę terenu oraz wyznaczono kierunki odpływu wód powierzchniowych przed i po zagospodarowaniu działki d (Ryc. 1). Czasochłonne i kosztochłonne badania geologiczne wykonano w minimalnym zakresie (Tab. 1) i zostały one wykorzystane jako informacja uzupełniająca, pozwalająca na ocenę możliwości infiltracji wody w podłoże. Na podstawie przeprowadzonych badań stwierdzono, że główne przyczyny problemów z odwodnieniem terenu związane są ze stworzeniem barier w postaci podmurówek ogrodzeń zlokalizowanych prostopadle do kierunków odpływu wody (Fot. 1, Fot. 2). Zmiany rzeźby były w analizowanym przypadku czynnikiem mniej istotnym. <strong>Słowa kluczowe:</strong> warunki hydrologiczne, infiltracja, model rzeźby terenu, kierunki odpływu, użytkowanie terenu, tereny zurbanizowane. <strong>Abstract</strong> The paper discusses the possibilities of employing GIS for conducting analysis of changes in hydrological conditions. The study was carried out in an urban area featuring altered relief and use of land. This caused problems with draining the terrain, particularly at times of increased rainwater and meltwater supply. In order to identify the causes of the occurring problems, we compared land relief prior and after the plot was developed, as well as indicated the directions of surface water runoff (Fig. 1). Time-consuming and expensive geological research activities were restricted to minimum (Tab. 2) and the data thus obtained were used as supplementary information to assess the capacity for water infiltration into the ground. The study enabled us to draw a conclusion that the main cause of the drainage problems is related to the construction of barriers, i.e. fencing base running perpendicular to the direction of water runoff (Photo 1 and 2). The changes in land relief were in this case of lesser importance. <strong>Key words:</strong> hydrological conditions, infiltration, digital elevation model, runoff directions, land use, urban areas.