Relevant bibliographies by topics / Opioid dependence

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Opioid dependence'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Opioid dependence"

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Lazcano, A. I. López, L. Ortega, A. Fauli, C. Busquets, and A. Lligoña. "Prescription opioid abuse, addiction and psychopathology in a pain clinic." European Psychiatry 41, S1 (2017): s869. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1744.

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IntroductionThere has been an escalation of therapeutic use and abuse of opioids. Aberrant drug related behaviors (ADRB) have prevalence between 2.8% and 62.2% in chronic pain patients treated with opioids and dependence is estimated around 3.27%.ObjectivesTo estimate the prevalence of dependence, ADRB, risk of opioid abuse, and co-occurring disorders in patients with chronic pain in our environment.MethodsA total of 115 (n = 115) patients attending our pain clinic were screened to evaluate the risk of opioid abuse and presence of dependence including a clinical interview, hamilton depression
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Daoust, R., J. Paquet, J. Morris, et al. "P026: Opioid use and dependence three months after an emergency department visit for acute pain." CJEM 20, S1 (2018): S66. http://dx.doi.org/10.1017/cem.2018.224.

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Introduction: Most studies evaluating prescription opioid dependence or misuse are retrospective and are based on prescription filling rates from pharmaceutical databases. These studies cannot evaluate if opioids are really consumed nor differentiate if used for a new pain, chronic pain, or for misuse/dependence. The aim of this study was to assess the opioid consumption in emergency department (ED) patients three months after discharge with an opioid prescription. Methods: This prospective cohort study was conducted in the ED of a tertiary care centre with a convenience sample of patients age
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Levin, Marc, Michael G. Roskies, and Jamil Asaria. "Perspectives of Facial Plastic Surgeons on Opioid Dependence in Rhinoplasty Patients." Facial Plastic Surgery 35, no. 05 (2019): 540–45. http://dx.doi.org/10.1055/s-0039-1693133.

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AbstractUnderstanding the perspectives and opinions of facial plastic surgeons on opioid dependence is critical in a national epidemic of opioid overuse. Findings may encourage surgeon education so that facial plastic surgeons may be able to judiciously prescribe opioids, improving patient outcomes and reducing healthcare opioid-related spending. The objective of this study is to understand facial plastic surgeons' perspectives on opioid dependence in rhinoplasty patients. A key secondary objective was to quantify facial plastic surgeons' opioid prescribing patterns. This was a prospective sur
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Colson, James. "Office-Based Opioid Dependence Treatment." July 2012 3S;15, no. 3S;7 (2012): ES231—ES236. http://dx.doi.org/10.36076/ppj.2012/15/es231.

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Background: Opioid misuse and abuse occurring in association with the treatment of chronic non-cancer pain are not new phenomena, but their increasing prevalence in recent years is unprecedented. Advancements in pharmaceutical technologies have provided opioid-related drugs, which lack the pure mu agonist activity characteristic of the typical opioid congeners. This absent or altered mu receptor activity imparts an opioid receptor antagonistic or partial agonistic pharmacologic action, which serves to modulate the development of opioid-induced tolerance and physical dependence and facilitate d
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Serani, Krisli, Hira Aslam, Syed Hyder Raza Naqvi, Shaheryar Shafqat, Avrina Kartika Ririe, and Sudhair Abbas Bangash. "Mechanisms Of Opioid-Induced Hyperalgesia: Implications For Chronic Pain Management." Journal of Neonatal Surgery 14, no. 30S (2025): 729–45. https://doi.org/10.63682/jns.v14i30s.7038.

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Background: Our understanding of opioid pharmacology has expanded significantly in recent years. Both naturally occurring and synthetic opioids bind to specific receptor types, which play a key role in their effects and mechanisms of action. Objective: To provide an overview of the opioid receptor types, their classifications, associated pharmacological effects, mechanisms of dependence, and key aspects of opioid pharmacokinetics, interactions, and therapeutic uses. Methods: A comprehensive analysis of opioid receptor families, including nociceptin, mu, kappa, and delta, and their pharmacologi
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Owais Kareem, Muhammad Asif, Sohaib Hassan, Muqaddas Abaid, Muhammad Ashrib, and Muhammad Arqam Arshad. "Severity of opioid dependence and its relation with psychosocial factors of users." Professional Medical Journal 28, no. 11 (2021): 1604–10. http://dx.doi.org/10.29309/tpmj/2021.28.11.6638.

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Objectives: To determine the relationship between severe opioid dependence and psychosocial factors of users Study Design: Descriptive Cross Sectional study. Setting: Department of Psychiatry Nishtar Hospital Multan. Period: Nov 2018 to May 2020. Material & Methods: 196 participants were enrolled through non probability purposive sampling technique. Pearson chi square test was applied to identify significant relationship between severe opioid dependence and psychosocial factors. Result: Mean age of study cases was 30.86 ± 1.66. The frequency of severe opioid dependence was noted in 159 (81
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Williams, John T., MacDonald J. Christie, and Olivier Manzoni. "Cellular and Synaptic Adaptations Mediating Opioid Dependence." Physiological Reviews 81, no. 1 (2001): 299–343. http://dx.doi.org/10.1152/physrev.2001.81.1.299.

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Although opioids are highly effective for the treatment of pain, they are also known to be intensely addictive. There has been a massive research investment in the development of opioid analgesics, resulting in a plethora of compounds with varying affinity and efficacy at all the known opioid receptor subtypes. Although compounds of extremely high potency have been produced, the problem of tolerance to and dependence on these agonists persists. This review centers on the adaptive changes in cellular and synaptic function induced by chronic morphine treatment. The initial steps of opioid action
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Perimbeti, Stuthi Pavani, Kevin Ye Hou, Sabarina Ramanathan, et al. "Opioid Dependency Significantly Increases Complications and Mortality in Sickle Cell Disease." Blood 132, Supplement 1 (2018): 4701. http://dx.doi.org/10.1182/blood-2018-99-120012.

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Abstract Introduction: According to the National Center for Health Statistics, there was a twenty-one percent increase in deaths from drug overdose in the USA, with opioids contributing to about two-thirds of these deaths. Despite nationwide efforts to reduce opioid use, narcotic pain medications are still the most frequently used method of pain control in patients with sickle cell disease (SCD). We sought to examine the burden and complications of opioid dependence in patients with SCD. Methods: The National Inpatient Sample (NIS) for the years 1999 to 2014 was queried to yield adult admissio
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Bakhshaie, Jafar, James D. Doorley, Nathaniel R. Choukas, Nathan S. Fishbein, Victoria A. Grunberg, and Ana-Maria Vranceanu. "Cannabis Co-Use Among Black Individuals with Chronic Pain Who Use Opioids: Associations with Other Substance Use and Pain Related Outcomes." Journal of Health Care for the Poor and Underserved 35, no. 2 (2024): 564–82. http://dx.doi.org/10.1353/hpu.2024.a928633.

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Abstract: Background Black individuals with chronic musculoskeletal (MSK) pain tend to experience worse pain and opioid use-related outcomes, including other substance co-use, compared with non-Hispanic White individuals. Co-using cannabis with opioids could instigate a cascade of pain-related vulnerabilities and poor outcomes. Here, we test associations between cannabis/opioid co-use and pain-related outcomes among Black individuals with chronic MSK pain. Methods Black adults with chronic MSK pain who use opioids ( N =401; 51.62% female, Mage =35.90, SD =11.03) completed online measures of pa
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Villarreal, Elvia L., Steven E. Wolf, George Golovko, et al. "26 Opioid Prescription in Burns: A Large Database Analysis from 1990 to 2021." Journal of Burn Care & Research 43, Supplement_1 (2022): S19—S20. http://dx.doi.org/10.1093/jbcr/irac012.029.

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Abstract Introduction The use of opioids in the medical field has contributed to the growing opioid epidemic. Nonetheless, opioids remain imperative in the treatment for pain management in burns. While some studies have addressed the use of opioids in surgery, a comprehensive analysis of the pattern of opioids use in burns has not been investigated. This study aims to identify trends of opioid use and investigate the risk of opioid related disorders in burn patients. Methods Data was obtained from TriNetX, a national research database that provides medical records of de-identified patients. Th
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Dissertations / Theses on the topic "Opioid dependence"

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Nosyk, Bohdan. "Empirical studies in opioid dependence." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23718.

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Background: Opioid dependence is a chronic disease characterized by periods of relapse and remission. Methadone maintenance treatment (MMT) can be effective, though not all patients can be successfully maintained in treatment. Further, treatment entrants often use multiple illicit drugs, a fact whose motive and effect are under-studied. Rigorous evaluation at the aggregate- and patient-level is required to maximize the public health benefits of substance abuse treatment. Objectives: (1) identify the determinants of the time to discontinuation of MMT across multiple treatment episodes; (2
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Edmund, Christine Hilary. "Correctional Nurses: Adult Opioid Dependence Referral Process." NSUWorks, 2017. https://nsuworks.nova.edu/hpd_con_stuetd/26.

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Background: Correctional nurses make up a large part of the corrections workforce and have increasing responsibility for making decisions about patient care in the opioid dependent incarcerated patients. The National Commission on Correctional Health Care (NCCHC) has intoxication and withdrawal standards that advocate individuals entering a correctional facility under the influence or undergoing withdrawal from opioids have their therapy continued, or a plan for appropriate referral for treatment. The NCCHC standard that incarcerated opioid dependent inmates have their therapy continued or a p
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Bilsky, Edward James 1967. "Studies on opioid delta receptor mediated antinociception, opioid antinociceptive tolerance and physical dependence." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282311.

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The central hypothesis of this dissertation is that agonists and antagonists acting at the delta opioid receptor will have therapeutic applications in treating acute and chronic pain states and in the treatment of drug addiction. It is further hypothesized that delta compounds will have better therapeutic profiles than currently available opioids that act predominantly at the mu receptor. In advancing the central hypothesis, selective nonpeptidic delta compounds, that readily cross the blood brain barrier after systemic administration, were tested. BW373U86, a nonpeptidic ligand with moderate
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Weich, Lize, Charles Perkel, Zyl Nicolette Van, S. T. Rataemane, and Lochan Naidoo. "Medical management of opioid dependence in South Africa." Health and Medical Publishing Group (HMPG), 2008. http://hdl.handle.net/10019.1/7055.

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The original publication is available at http://www.samj.org.za<br>Medical practitioners in South Africa are increasingly confronted with requests to treat patients with opioid use disorders. Many do not possess the required knowledge and skills to deal with these patients effectively. This overview of the medical treatment of opioid dependence was compiled by an elected working group of doctors working in the field of substance dependence. Recommendations are based on current best practice derived from scientific evidence and consensus of the working group, but should never replace individual
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Fundytus, Marian Elaine. "Contribution of metabotropic glutamate receptors to opioid dependence." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ29938.pdf.

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Johansson, Anna. "Dependence-induced changes in opioid-receptor gene expression." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90034.

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Using drugs such as alcohol and morphine among others can be addictive in some individuals, and progress into a substance abuse disorder. The mesolimbic dopaminergic system (MD-system) is involved in the reward process during the development of drug addiction. The MD-system is critical for survival and affects different behaviors in both man and animal. Neurochemical pathways drive for instance physical activity, food intake, love and reproduction and are part of the natural reward process involved partly in the release of dopamine (DA) into frontal lobes. Within the MD-system opioid receptors
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Fundytus, Marian Elaine. "Contribution of metabotropic glutamate receptors to opioid dependence." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42034.

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We investigated the role of metabotropic glutamate receptors (mGluRs), and related intracellular second messengers, in the development of morphine tolerance and dependence. The mGluRs are divided into three groups: group I mGluRs are positively coupled to phosphatidylinositol (PI) hydrolysis, while group II and III mGluRs are negatively coupled to cyclic adensoine-3$ sp prime$,5$ sp prime$-monophosphate (cAMP) production. Opioid receptors are also coupled to these same systems, and have been shown to elicit changes in these messenger systems during chronic treatment.<br>We showed that chronic
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Grivas, Konstantinos. "Analogues of buprenorphine as treatment for opioid dependence." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294430.

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Higgins, Cassandra. "Comorbid opioid dependence and chronic pain : clinical implications." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/bbc038cc-562c-4e01-a617-147de73b1312.

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Context Chronic pain and opioid dependence confer substantial individual and societal burdens and are notoriously difficult to treat effectively. Their comorbid presentation further complicates effective treatment through complex physiological and environmental interactions. Objectives (1) What are the clinical characteristics and treatment outcomes associated with comorbid chronic pain in ORT patients? (2) Does the patient-attributed direction of the causal relationship in the development of opioid dependence and chronic pain identify two clinically-distinct treatment populations? (3) What is
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Cradick, Mary, Shannon DeGrote, Spencer Marsall, and Terri Warholak. "Suboxone for Medically Assisted Treatment for Opioid Dependence." The University of Arizona, 2014. http://hdl.handle.net/10150/614151.

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Class of 2014 Abstract<br>Specific Aims: To show that Suboxone is more effective than no MAT (Medically Assisted Treatment) in opioid dependence. Additionally, that Suboxone is as effective as methadone in MAT. Methods: This study was a retrospective chart review of probationer’s case files at The Pima County Adult Probation Office. Treatment groups included: Suboxone (n=16), methadone (n=15), and no MAT control group (n=15). The total sample size was 46 probationers. The primary dependent variables were the number of negative events and tim
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Books on the topic "Opioid dependence"

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McAnally, Heath B. Opioid Dependence. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-47497-7.

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C, Strain Eric, and Stitzer Maxine L, eds. The treatment of opioid dependence. Johns Hopkins University Press, 2005.

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C, Strain Eric, and Stitzer Maxine L, eds. Methadone treatment for opioid dependence. Johns Hopkins University Press, 1999.

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Greenwald, Mark. Human experimental therapeutic models in opioid dependence. Nova Science Publishers, 2008.

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D, Blaine Jack, ed. Buprenorphine: An alternative treatment for opioid dependence. U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, 1992.

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S, Rapaka Rao, Sorer Heinz, and National Institute on Drug Abuse., eds. Discovery of novel opioid medications. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Institute on Drug Abuse, 1995.

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Renner, John A., and Petros Levounis. Handbook of office-based buprenorphine treatment of opioid dependence. American Psychiatric Pub., 2010.

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E, Arif A., and Westermeyer Joseph 1937-, eds. Methadone maintenance in the management of opioid dependence: An international review. Praeger Publishers, 1990.

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M, Stine Susan, and Kosten Thomas R, eds. New treatments for opiate dependence. Guilford Press, 1997.

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1942-, Cowan Alan, and Lewis John W, eds. Buprenorphine: Combatting drug abuse with a unique opioid. Wiley-Liss, 1995.

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Book chapters on the topic "Opioid dependence"

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McAnally, Heath B. "An Epidemiologic Perspective." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_1.

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McAnally, Heath B. "Opioid Dependence Risk Factors and Risk Assessment." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_10.

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McAnally, Heath B. "Addressing Host Factors: Primary, Secondary, and Tertiary Prevention of Opioid Dependence." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_11.

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McAnally, Heath B. "Understanding the Agent, Part I: Opioid Biology and Basic Pharmacology." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_2.

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McAnally, Heath B. "Understanding the Agent, Part II: Adverse Effects." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_3.

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McAnally, Heath B. "Understanding the Agent, Part III: Specific Drugs." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_4.

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McAnally, Heath B. "Attenuating the Agent: Reducing Opioid “Virulence”." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_5.

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McAnally, Heath B. "Best Practices Education, Part I: Pain Physiology, Psychology, and Alternatives to Opioids." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_6.

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McAnally, Heath B. "Best Practices Education, Part II: Evidence for and Against Opioid Therapy." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_7.

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McAnally, Heath B. "Best Practices Education, Part III: Regulatory and Advisory Issues Related to Opioid Therapy for Pain." In Opioid Dependence. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47497-7_8.

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Conference papers on the topic "Opioid dependence"

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Astaf'eva, E. A., T. A. Tolochko, and A. A. Timofeeva. "THE EFFECT OF POLYMORPHISM OF THE MTHFR C677T GENE ON THE MORPHOFUNCTIONAL STATE OF LYMPHOCYTES DURING DRUG INTOXICATION." In I International Congress “The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies”. Kemerovo State University, 2023. http://dx.doi.org/10.21603/-i-ic-8.

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The prevalence of opioid dependence among the able-bodied population is an important&#x0D; medical and social problem. Methylenetetrahydrofolate reductase (MTHFR) plays a key role in the&#x0D; metabolism of narcotic drugs. A decrease in the enzyme activity in polymorphic variants of the&#x0D; gene encoding it is associated with a decrease in the immunity of opioid addiction patients.
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Nazarova, G. A., N. G. Bogdanova, E. V. Alekseeva, and S. K. Sudakov. "INTERMITTENT USE OF SOLUTIONS OF GLUCOSE, SODIUM CHLORIDE AND MONOSODIUM GLUTAMATE CAUSES ENDOGENOUS OPIOID DEPENDENCE." In MODERN PROBLEMS IN SYSTEMIC REGULATION OF PHYSIOLOGICAL FUNCTIONS. NPG Publishing, 2019. http://dx.doi.org/10.24108/5-2019-confnf-59.

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Mehtry, Vijay, Nizamuddin Parvez, Haque Nizamie, and Nityananda Pradhan. "Altered Brain Function as Evidenced by Electroencephalographic Power Spectral Analysis in Patients with Opioid Dependence." In Annual International Conference on Neuroscience and Neurobiology Research. Global Science & Technology Forum (GSTF), 2014. http://dx.doi.org/10.5176/2345-7813_cnn14.01.

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Gómez-Carreño, Carlos Rodríguez, Antonio Ramírez García, Luis Beato Fernández, Irene Díaz Quero, and Estefanía Segura Escobar. "Craving and Priming of alcohol in depressive disorders. Bibliographic review and new therapies." In 22° Congreso de la Sociedad Española de Patología Dual (SEPD) 2020. SEPD, 2020. http://dx.doi.org/10.17579/sepd2020p140.

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Acute alcohol consumption produces positive reinforcement effects, through activation of brain reward circuit, includes limbic system structures (accumbens system and hippocampus). The comorbidity of depressive episode and alcohol abuse makes it necessary to propose new strategies for the treatment of this frequent clinical situation. We conducted a literature review of the combined treatments for major depressive disorder (MDD) with alcohol abuse. We review current literature on the use of new treatments in alcohol consumption with pattern of abuse (binge drinking). Recent studies support the
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El-Shammaa, Nardin, Kyle Street, and Narshima Pinninti. "Release the Kratom: Post-Acute Withdrawal Syndrome in a 70 Year Old Male." In 27th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2023. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.110_2023.

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Centuries in Eastern medicine.. Kratom has been commonly used for chronic pain and opiate withdrawal symptoms with first reported cases in the United States in the early 2000s. It is a plant that consists of psychoactive alkaloids that target opioid receptors with different affinity. Effects from Kratom are dose-dependent, at lower doses, it acts as a stimulant, while at higher doses produces analgesia and euphoria. Although Kratom is legal and easily accessible over the counter, there have been increasing reports of potential for addiction and toxicity. Cessation of Kratom can result in withd
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Haddad, Imad Y., Teresa L. Reyburn-Orne, Rima Abdouni, and Tarek H. Youssef. "Impact Of Standardized Clinical Practice Guideline On Methadone Exposure And Hospital Length Of Stay In Children With Latrogenic Opioid Dependence." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2941.

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Elias, Jonathan, Lothar Vidal, and Richard Jermyn. "Utilizing Microwave Ablation in Combination with Vertebroplasty Is an Effective Method in Reducing Cancer Related Back Pain, Disability, and Opioid Use: A Systematic Review and Meta-Analysis." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.211_2024.

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Background: It is estimated that metastases from primary malignant neoplasms affect the spine around 30%-70% of the time. Many times, these osteolytic tumors will cause the degradation of the vertebrae, leaving patients in a tremendous amount of pain, disability, and dependence on opioids as analgesics. Microwave ablation (MWA) followed by vertebroplasties (VP) has been a developing treatment for such a condition; however, there are no systematic reviews or meta-analyses examining the method’s effectiveness thus far. Purpose: This systematic review and meta-analysis analyzes the 4-week and 12-
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SANTOS, AMANDA CORDEIRO, ANA KAROLINE DE ALMEIDA MENDES, DANIELLE BRENA DANTAS TARGINO, RENATO MARCELO SILVA ALEXANDRE FILHO, LUIZA VITORIA DE SOUSA BARROS FONSECA, and CAIO RODRIGUES LIMA NEUENSCHWANDER. "DEPENDÊNCIA DE OPIOIDE NO TRATAMENTO DE DOR CRÔNICA." In Brazilian Congress. brazco, 2020. http://dx.doi.org/10.51162/brc.health2020-00056.

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A Associacao Internacional para o Estudo da Dor (IASP) define: A dor e uma experiencia sensorial e emocional desagradavel, associada a dano real ou potencial de tecidos ou descrita em termos de tal dano , e de acordo com o Ministerio da Saude (MS), consiste como fator alarmante de saude publica pelo numero acentuado de individuos acometidos. A dor cronica notabiliza-se por uso prolongado de tratamento com efeito analgesico. Dentre os farmacos, destacam-se os opioides, classe medicamentosa na qual a acao analgesica e produzida a nivel de sistema nervoso central, em areas especificas relacionada
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Patil, Sushil G., Timothy J. Gale, and Clive R. Stack. "Design of Novel Assessment Techniques for Opioid Dependent Patients." In 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2007. http://dx.doi.org/10.1109/iembs.2007.4353144.

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Jessup, Donald, and Hamid I. Akbarali. "Butyrate Prevents Opioid Induced Peripheral Hypersensitivity via a Gut Dependent Mechanism." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.169830.

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Reports on the topic "Opioid dependence"

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King, Ebony. Plain Language Summary: Naltrexone Utilization Along its Dosing Spectrum - a Literature Review. WritePharma, 2025. https://doi.org/10.70390/cwc0auh7n.

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Naltrexone, a widely recognized opioid receptor antagonist, has been primarily used at standard doses of 50–100 mg daily to treat opioid and alcohol use disorders. Recent studies, however, reveal its versatility across a broader dosing spectrum. This review examines the therapeutic effects and safety profiles of naltrexone across three dosing strategies: standard doses for substance use disorders, low-dose naltrexone (LDN, 1–5 mg/day) for chronic pain and autoimmune diseases, and ultra-low-dose naltrexone (ULDN, microgram levels) as a complement to opioid therapy. However, naltrexone’s role in
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Romero Martínez, Shairine, and Ariel Enrique Pastrana Arias. Tecnologías emergentes:heroina. Universidad de Cartagena, 2021. https://doi.org/10.32997/11227/18444.

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Abstract:
A pesar del éxito de la vacunación en la mitigación o eliminación de la amenaza de enfermedades causadas por patógenos, siguen existiendo enfermedades para las cuales el desarrollo de vacunas exitosas contra ellas es difícil. Hoy día se ha avanzado significativamente en la comprensión de la inmunología de las vacunas por lo que se puede orientar el desarrollo de vacunas para enfermedades que tradicionalmente no se han abordado con la vacunación, entre estas enfermedades se encuentra el trastorno por abuso de sustancias. Lo que se busca con estas vacunas es provocar una respuesta humoral (antic
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3

McDonagh, Marian S., Jesse Wagner, Azrah Y. Ahmed, Benjamin Morasco, Devan Kansagara, and Roger Chou. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: May 2021 Update. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepccerplantpain3.

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Overview This is the third quarterly progress report for an ongoing living systematic review on cannabis and other plant-based treatments for chronic pain. The first progress report was published in January 2021 and the second in March 2021. The draft systematic review was available for public comment from May 19 through June 15, 2021, on the Agency for Healthcare Research and Quality (AHRQ) Effective Health Care website. The systematic review synthesizes evidence on the benefits and harms of plant-based compounds (PBCs), such as cannabinoids and kratom, used to treat chronic pain, addressing
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