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Journal articles on the topic 'Opioid dependence'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lazcano, A. I. López, L. Ortega, A. Fauli, C. Busquets, and A. Lligoña. "Prescription opioid abuse, addiction and psychopathology in a pain clinic." European Psychiatry 41, S1 (2017): s869. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1744.

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IntroductionThere has been an escalation of therapeutic use and abuse of opioids. Aberrant drug related behaviors (ADRB) have prevalence between 2.8% and 62.2% in chronic pain patients treated with opioids and dependence is estimated around 3.27%.ObjectivesTo estimate the prevalence of dependence, ADRB, risk of opioid abuse, and co-occurring disorders in patients with chronic pain in our environment.MethodsA total of 115 (n = 115) patients attending our pain clinic were screened to evaluate the risk of opioid abuse and presence of dependence including a clinical interview, hamilton depression

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Daoust, R., J. Paquet, J. Morris, et al. "P026: Opioid use and dependence three months after an emergency department visit for acute pain." CJEM 20, S1 (2018): S66. http://dx.doi.org/10.1017/cem.2018.224.

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Introduction: Most studies evaluating prescription opioid dependence or misuse are retrospective and are based on prescription filling rates from pharmaceutical databases. These studies cannot evaluate if opioids are really consumed nor differentiate if used for a new pain, chronic pain, or for misuse/dependence. The aim of this study was to assess the opioid consumption in emergency department (ED) patients three months after discharge with an opioid prescription. Methods: This prospective cohort study was conducted in the ED of a tertiary care centre with a convenience sample of patients age

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Levin, Marc, Michael G. Roskies, and Jamil Asaria. "Perspectives of Facial Plastic Surgeons on Opioid Dependence in Rhinoplasty Patients." Facial Plastic Surgery 35, no. 05 (2019): 540–45. http://dx.doi.org/10.1055/s-0039-1693133.

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AbstractUnderstanding the perspectives and opinions of facial plastic surgeons on opioid dependence is critical in a national epidemic of opioid overuse. Findings may encourage surgeon education so that facial plastic surgeons may be able to judiciously prescribe opioids, improving patient outcomes and reducing healthcare opioid-related spending. The objective of this study is to understand facial plastic surgeons' perspectives on opioid dependence in rhinoplasty patients. A key secondary objective was to quantify facial plastic surgeons' opioid prescribing patterns. This was a prospective sur

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Colson, James. "Office-Based Opioid Dependence Treatment." July 2012 3S;15, no. 3S;7 (2012): ES231—ES236. http://dx.doi.org/10.36076/ppj.2012/15/es231.

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Background: Opioid misuse and abuse occurring in association with the treatment of chronic non-cancer pain are not new phenomena, but their increasing prevalence in recent years is unprecedented. Advancements in pharmaceutical technologies have provided opioid-related drugs, which lack the pure mu agonist activity characteristic of the typical opioid congeners. This absent or altered mu receptor activity imparts an opioid receptor antagonistic or partial agonistic pharmacologic action, which serves to modulate the development of opioid-induced tolerance and physical dependence and facilitate d

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Serani, Krisli, Hira Aslam, Syed Hyder Raza Naqvi, Shaheryar Shafqat, Avrina Kartika Ririe, and Sudhair Abbas Bangash. "Mechanisms Of Opioid-Induced Hyperalgesia: Implications For Chronic Pain Management." Journal of Neonatal Surgery 14, no. 30S (2025): 729–45. https://doi.org/10.63682/jns.v14i30s.7038.

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Background: Our understanding of opioid pharmacology has expanded significantly in recent years. Both naturally occurring and synthetic opioids bind to specific receptor types, which play a key role in their effects and mechanisms of action. Objective: To provide an overview of the opioid receptor types, their classifications, associated pharmacological effects, mechanisms of dependence, and key aspects of opioid pharmacokinetics, interactions, and therapeutic uses. Methods: A comprehensive analysis of opioid receptor families, including nociceptin, mu, kappa, and delta, and their pharmacologi

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Owais Kareem, Muhammad Asif, Sohaib Hassan, Muqaddas Abaid, Muhammad Ashrib, and Muhammad Arqam Arshad. "Severity of opioid dependence and its relation with psychosocial factors of users." Professional Medical Journal 28, no. 11 (2021): 1604–10. http://dx.doi.org/10.29309/tpmj/2021.28.11.6638.

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Objectives: To determine the relationship between severe opioid dependence and psychosocial factors of users Study Design: Descriptive Cross Sectional study. Setting: Department of Psychiatry Nishtar Hospital Multan. Period: Nov 2018 to May 2020. Material & Methods: 196 participants were enrolled through non probability purposive sampling technique. Pearson chi square test was applied to identify significant relationship between severe opioid dependence and psychosocial factors. Result: Mean age of study cases was 30.86 ± 1.66. The frequency of severe opioid dependence was noted in 159 (81

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Williams, John T., MacDonald J. Christie, and Olivier Manzoni. "Cellular and Synaptic Adaptations Mediating Opioid Dependence." Physiological Reviews 81, no. 1 (2001): 299–343. http://dx.doi.org/10.1152/physrev.2001.81.1.299.

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Although opioids are highly effective for the treatment of pain, they are also known to be intensely addictive. There has been a massive research investment in the development of opioid analgesics, resulting in a plethora of compounds with varying affinity and efficacy at all the known opioid receptor subtypes. Although compounds of extremely high potency have been produced, the problem of tolerance to and dependence on these agonists persists. This review centers on the adaptive changes in cellular and synaptic function induced by chronic morphine treatment. The initial steps of opioid action

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Perimbeti, Stuthi Pavani, Kevin Ye Hou, Sabarina Ramanathan, et al. "Opioid Dependency Significantly Increases Complications and Mortality in Sickle Cell Disease." Blood 132, Supplement 1 (2018): 4701. http://dx.doi.org/10.1182/blood-2018-99-120012.

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Abstract Introduction: According to the National Center for Health Statistics, there was a twenty-one percent increase in deaths from drug overdose in the USA, with opioids contributing to about two-thirds of these deaths. Despite nationwide efforts to reduce opioid use, narcotic pain medications are still the most frequently used method of pain control in patients with sickle cell disease (SCD). We sought to examine the burden and complications of opioid dependence in patients with SCD. Methods: The National Inpatient Sample (NIS) for the years 1999 to 2014 was queried to yield adult admissio

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Bakhshaie, Jafar, James D. Doorley, Nathaniel R. Choukas, Nathan S. Fishbein, Victoria A. Grunberg, and Ana-Maria Vranceanu. "Cannabis Co-Use Among Black Individuals with Chronic Pain Who Use Opioids: Associations with Other Substance Use and Pain Related Outcomes." Journal of Health Care for the Poor and Underserved 35, no. 2 (2024): 564–82. http://dx.doi.org/10.1353/hpu.2024.a928633.

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Abstract: Background Black individuals with chronic musculoskeletal (MSK) pain tend to experience worse pain and opioid use-related outcomes, including other substance co-use, compared with non-Hispanic White individuals. Co-using cannabis with opioids could instigate a cascade of pain-related vulnerabilities and poor outcomes. Here, we test associations between cannabis/opioid co-use and pain-related outcomes among Black individuals with chronic MSK pain. Methods Black adults with chronic MSK pain who use opioids ( N =401; 51.62% female, Mage =35.90, SD =11.03) completed online measures of pa

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Villarreal, Elvia L., Steven E. Wolf, George Golovko, et al. "26 Opioid Prescription in Burns: A Large Database Analysis from 1990 to 2021." Journal of Burn Care & Research 43, Supplement_1 (2022): S19—S20. http://dx.doi.org/10.1093/jbcr/irac012.029.

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Abstract Introduction The use of opioids in the medical field has contributed to the growing opioid epidemic. Nonetheless, opioids remain imperative in the treatment for pain management in burns. While some studies have addressed the use of opioids in surgery, a comprehensive analysis of the pattern of opioids use in burns has not been investigated. This study aims to identify trends of opioid use and investigate the risk of opioid related disorders in burn patients. Methods Data was obtained from TriNetX, a national research database that provides medical records of de-identified patients. Th

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Shakya, Pooja, Ravindra Rao, Alok Agrawal, Roshan Bhad, Atul Ambekar, and Deepak Yadav. "Are People with Opioid Dependence Who Inject Opioids Different from Those Who Do Not? – Findings from a Cross-sectional, Observational, Community-based Study from North India." Indian Journal of Social Psychiatry 40, no. 1 (2024): 21–29. http://dx.doi.org/10.4103/ijsp.ijsp_337_23.

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Background: About one-fourth of individuals who are dependent on opioids use opioids through injecting route. Most of such individuals start using opioids through noninjecting route much earlier before they transition to injecting opioids. It is important to identify important factors that delineate individuals who inject opioids from those who use opioids through other routes, which was the objective of the present study. Methods: This was a cross-sectional study design. Four hundred treatment-naïve opioid users with opioid dependence were selected using a snowballing sampling technique. The

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Mourad, Mirella, Ruth Landau, Jason D. Wright, et al. "Oral Opioid Use during Vaginal Delivery Hospitalizations." American Journal of Perinatology 37, no. 04 (2019): 390–97. http://dx.doi.org/10.1055/s-0039-1678566.

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Objective This study aimed to determine the receipt of short-acting opioid medications during vaginal delivery hospitalizations. Study Design The Perspective database was analyzed to evaluate patterns of short-acting oral opioid use during vaginal delivery hospitalizations from January 2006 to March 2015. Unadjusted and adjusted models evaluating the role of demographic and hospital factors were created evaluating use of opioids. Hospital-level rates of opioid use were evaluated. Opioid receipt among women with opioid abuse or dependence was evaluated based on overall hospital rates of opioid

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&NA;. "Opioid dependence." Inpharma Weekly &NA;, no. 1168 (1998): 4. http://dx.doi.org/10.2165/00128413-199811680-00004.

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Benich, Joseph J. "Opioid Dependence." Primary Care: Clinics in Office Practice 38, no. 1 (2011): 59–70. http://dx.doi.org/10.1016/j.pop.2010.11.005.

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Burks, T. F., C. C. Bihm, G. C. Rosenfeid, and C. L. Williams. "Opioid Dependence." Japanese Journal of Pharmacology 82 (2000): 38. http://dx.doi.org/10.1016/s0021-5198(19)47632-4.

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Shekhar, Avinash, Sharad Phillip, and Aniruddha Basu. "Opioids and sexual health: A narrative review." Indian Journal of health sexuality and Culture 7, no. 1 (2021): 15–26. https://doi.org/10.5281/zenodo.5151806.

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Abstract Opioid dependence is the commonest drug dependence after cannabis worldwide. Physiologically, opioids, by their acute effects, cause enhanced sexual performance while used chronically; they cause sexual dysfunction primarily by influencing the hypothalamo-pituitary-adreno-gonadal axis. Men with opioid use had a significantly increased risk of erectile dysfunction with a relative risk of 1.96. Decrease in sexual desire/libido, anorgasmia, premature ejaculation, loss of ability to attain an erection, decreased sexual satisfaction after intercourse, amenorrhoea, anovulation are the criti

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Eichmeyer, Sarah, and Jonathan Zhang. "Pathways into Opioid Dependence: Evidence from Practice Variation in Emergency Departments." American Economic Journal: Applied Economics 14, no. 4 (2022): 271–300. http://dx.doi.org/10.1257/app.20210048.

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We use practice variation across physicians to uncover the role of medical care in causing opioid dependence. Using health records of 2 million US veterans with emergency department visits, we find that quasi-random assignment to a top (versus bottom) decile prescribing provider significantly increases subsequent opioid use and misuse rates. Instrumental variable results show that opioid prescription receipt leads to a 20 percent increase in the probability of long-term prescription opioid use and sizable increases in the development of opioid use disorder and opioid overdose mortality. We fin

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Ouyang, Handong, Shue Liu, Weian Zeng, Roy C. Levitt, Keith A. Candiotti, and Shuanglin Hao. "An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray." Scientific World Journal 2012 (2012): 1–9. http://dx.doi.org/10.1100/2012/940613.

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The chronic use of opiates (i.e., narcotics such as the natural derivatives of opium including morphine or codeine) or opioids (i.e., semisynthetic derivatives of opium and other molecules that activate opioid receptors) induces dependence, which is associated with various specific behavioral and somatic signs after their withdrawal or after the administration of an opioid antagonist. Among the brain regions implicated in opiate dependence and withdrawal, the periaqueductal gray area (PAG) appears to be critical in regulating the complex signs and symptoms of opioid withdrawal. Numerous neuroc

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Leung, Janni, Gary C. K. Chan, Samuel X. Tan, Caitlin McClure-Thomas, Louisa Degenhardt, and Wayne Hall. "State-Level Prevalence and Associates of Opioid Dependence in the USA." International Journal of Environmental Research and Public Health 19, no. 7 (2022): 3825. http://dx.doi.org/10.3390/ijerph19073825.

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Traditionally, opioid-related disease burden was primarily due to heroin use. However, increases in extra-medical (or non-medicinal use of prescription opioids; NMPOs) use has precipitated the current overdose epidemic in North America. We aim to examine the state-level prevalence of heroin and NMPO dependence and their associations with opioid-related mortality and state-level socio-demographic profiles. Data were pooled from the 2005–2014 National Survey on Drug Use and Health (NSDUH). We examine opioid-related mortality from CDC WONDER (Cause of Death database) by the past year prevalence o

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Concato, Monica, Emiliana Giacomello, Ibrahim Al-Habash, et al. "Molecular Sex Differences and Clinical Gender Efficacy in Opioid Use Disorders: From Pain Management to Addiction." International Journal of Molecular Sciences 25, no. 17 (2024): 9314. http://dx.doi.org/10.3390/ijms25179314.

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Opioids have been utilized for both medical and recreational purposes since their discovery. Primarily recognized for their analgesic properties, they are also associated with the development of tolerance and dependence, contributing to a significant public health concern worldwide. Sex differences in opioid use disorder reveal that while men historically exhibit higher rates of abuse, women may develop dependence more quickly and are more susceptible to the addictive nature of opioids. This narrative review explores sex differences in opioid response in both clinical and experimental models,

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McDonough, MBBS, Mike, Jacinta L. Johnson, PhD, Jason M. White, PhD, and Femke T. A. Buisman-Pijlman, PhD. "Measuring opioid dependence in chronic pain patients: A comparison between addiction clinic and pain clinic patient populations." Journal of Opioid Management 15, no. 4 (2019): 285–93. http://dx.doi.org/10.5055/jom.2019.0514.

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Objective: To compare dependence characteristics between patients with chronic pain treated within an addiction medicine setting with those attending specialist pain clinics.Setting and patients: Forty patients with chronic non-cancer pain taking opioid analgesics for 1 year were recruited from university-affiliated, tertiary teaching hospital clinics; 20 from an addiction medicine clinic (addiction clinic group) and 20 from specialist pain clinics (pain clinic group).Design and main outcome measures: Data regarding demographics, past and current substance use, pain history and current daily o

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Sedney, Cara L., Patricia Dekeseredy, Marissa Davis, and Treah Haggerty. "A qualitative study of chronic pain and opioid use: The impact of restrictive prescribing." Journal of Opioid Management 19, no. 7 (2023): 95–102. http://dx.doi.org/10.5055/jom.2023.0803.

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Objectives: To explore the continuum of pain and addiction for patients with chronic pain (CP) who used opioids during a time of restrictive opioid prescribing in West Virginia. Design: This qualitative descriptive study used a content analysis of semi-structured interviews. Themes were identified through a reflective, iterative coding process. Consolidated criteria for reporting qualitative research guidelines were followed. Setting: West Virginia. Participants: Twenty people who used opioids to treat a CP condition, 10 pharmacists, 10 primary care providers, and 10 speciali

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Fink, Brandi C., Olivier Uyttebrouck, and Richard S. Larson. "An Effective Intervention: Limiting Opioid Prescribing as a Means of Reducing Opioid Analgesic Misuse, and Overdose Deaths." Journal of Law, Medicine & Ethics 48, no. 2 (2020): 249–58. http://dx.doi.org/10.1177/1073110520935336.

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Overdose deaths involving prescription opioids killed more than 17,000 Americans in 2017, marking a five-fold increase since 1999. High prescribing rates of opioid analgesics have been a substantial contributor to prescription opioid misuse, dependence, overdose and heroin use. There was recognition approximately ten years ago that opioid prescribing patterns were contributing to this startling increase in negative opioid-related outcomes, and federal actions, including Medicare reimbursement reform and regulatory actions, were initiated to restrict opioid prescribing. The current manuscript i

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Kjome, Kimberly L., and F. Gerard Moeller. "Long-Acting Injectable naltrexone for the Management of patients with Opioid Dependence." Substance Abuse: Research and Treatment 5 (January 2011): SART.S5452. http://dx.doi.org/10.4137/sart.s5452.

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Opioid dependence is a condition with serious clinical ramifications. Treatment has focused on detoxification, agonist therapy with methadone or buprenorphine, or remission maintenance with the opioid antagonist, naltrexone. Treatment with oral naltrexone has been limited by poor treatment adherence and relapse. Studies with long-acting formulations have shown increased treatment adherence. Extended-release injectable naltrexone has been used for the treatment of alcohol dependence, and has recently received an indication for treatment of opioid dependence from the US Food and Drug Administrat

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Gupta, Atul, Junaid Nizamuddin, Dalia Elmofty, et al. "Opioid Abuse or Dependence Increases 30-day Readmission Rates after Major Operating Room Procedures." Anesthesiology 128, no. 5 (2018): 880–90. http://dx.doi.org/10.1097/aln.0000000000002136.

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Abstract Background Although opioids remain the standard therapy for the treatment of postoperative pain, the prevalence of opioid misuse is rising. The extent to which opioid abuse or dependence affects readmission rates and healthcare utilization is not fully understood. It was hypothesized that surgical patients with a history of opioid abuse or dependence would have higher readmission rates and healthcare utilization. Methods A retrospective cohort analysis was performed of patients undergoing major operating room procedures in 2013 and 2014 using the National Readmission Database. Patient

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Bohl, Daniel D., Emily Hejna, Nasima Mehraban, et al. "Postoperative Opioid Dependence following Orthopaedic Foot and Ankle Surgery: A Cohort Study of 448 Patients." Foot & Ankle Orthopaedics 5, no. 4 (2020): 2473011420S0013. http://dx.doi.org/10.1177/2473011420s00138.

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Category: Other Introduction/Purpose: Surgeon prescription of narcotic medications has been identified as a contributor to the nation’s devastating opioid epidemic. The purpose of this study is to identify risk factors for postoperative opioid dependence following orthopaedic foot and ankle surgery. Methods: Four hundred and forty-eight patients undergoing orthopaedic foot and ankle surgery at a single institution over a 6- month period were identified. The Illinois Prescription Monitoring Program was used to track opioid prescriptions filled in the preoperative, perioperative, and postoperati

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Vitzthum, Lucas K., Paul Riviere, Paige Sheridan, et al. "Predicting Persistent Opioid Use, Abuse, and Toxicity Among Cancer Survivors." JNCI: Journal of the National Cancer Institute 112, no. 7 (2019): 720–27. http://dx.doi.org/10.1093/jnci/djz200.

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Abstract Background Although opioids play a critical role in the management of cancer pain, the ongoing opioid epidemic has raised concerns regarding their persistent use and abuse. We lack data-driven tools in oncology to understand the risk of adverse opioid-related outcomes. This project seeks to identify clinical risk factors and create a risk score to help identify patients at risk of persistent opioid use and abuse. Methods Within a cohort of 106 732 military veteran cancer survivors diagnosed between 2000 and 2015, we determined rates of persistent posttreatment opioid use, diagnoses of

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Weekes, Danielle G., Jenna A. Feldman, Richard E. Campbell, Michael DeFrance, Fotios P. Tjoumakaris, and Luke Austin. "The Incidence of Chronic Opioid Use Following Arthroscopic Rotator Cuff Repair and Patient Opioid Education." Orthopaedic Journal of Sports Medicine 7, no. 7_suppl5 (2019): 2325967119S0025. http://dx.doi.org/10.1177/2325967119s00258.

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Objectives: Opioids are commonly prescribed for pain management following Arthroscopic Rotator Cuff Repair (ARCR). While their efficacy outweighs their risks in the short term, chronic opioid use is associated with significant adverse effects, such as dependence, endocrine imbalance or respiratory depression. The rate of chronic opioid use and dependence following ARCR is unknown. The purpose of this study is to determine the rate of chronic opioid use following ARCR and establish the effect of preoperative opioid education on reducing chronic consumption. A secondary aim is to determine if an

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Fowler, Megan, Samina Ali, Serge Gouin, et al. "Knowledge, attitudes, and practices regarding opioid use in the pediatric emergency department." Paediatrics & Child Health 23, suppl_1 (2018): e10-e10. http://dx.doi.org/10.1093/pch/pxy054.026.

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Abstract BACKGROUND Inadequate pain management in children is ubiquitous in the emergency department (ED). Inadequate pain management in children can have both short and long term detrimental effects. As the current national opioid crisis has highlighted, physicians are caught between balancing pain management and the risk of long term opioid dependence. OBJECTIVES This study aimed to describe paediatric emergency physicians’ (PEPs) willingness to prescribe opioids to children in the ED and at discharge, perceived knowledge regarding common fears and myths about opioid use, management approach

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Fowler, M. A., S. Ali, N. Poonai, et al. "LO85: Knowledge, attitudes, and practices regarding opioid use in the pediatric emergency department." CJEM 20, S1 (2018): S37. http://dx.doi.org/10.1017/cem.2018.147.

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Introduction: Inadequate pain management in children is ubiquitous in the emergency department (ED). As the current national opioid crisis has highlighted, physicians are caught between balancing pain management and the risk of long term opioid dependence. This study aimed to describe pediatric emergency physicians (PEPs) willingness to prescribe opioids to children in the ED and at discharge. Methods: A unique survey tool was created using published methodology guidelines. Information regarding practices, knowledge, attitudes, perceived barriers, facilitators and demographics were collected.

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Ahmed, Sagir G., Umma A. Ibrahim, and Modu B. Kagu. "Opioid dependence among people with haemophilia in a low-resource tropical setting: prevalence and risk factors in northern Nigeria." Journal of Haemophilia Practice 6, no. 1 (2019): 19–28. http://dx.doi.org/10.17225/jhp00132.

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Abstract Background: In tropical countries such as Nigeria, where factor VIII (FVIII) is scarce, severe pain due to musculoskeletal bleeding complications, leading to frequent opioid prescription, is not uncommon in poorly managed people with haemophilia (PWH). The relationship between opioid use and dependence is intensively studied in other painful diseases, such as cancer and rheumatoid arthritis, but surprisingly little is known about opioid dependence in haemophilia. We hypothesise that the risk of opioid dependence among PWH in tropical countries like Nigeria is multi-factorial, encompas

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Keeven, David, Jonathan Vacek, Matthew Bozeman, et al. "70 Burn Injury is Not a Risk Factor for Long-term Opioid Use." Journal of Burn Care & Research 44, Supplement_2 (2023): S35. http://dx.doi.org/10.1093/jbcr/irad045.044.

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Abstract Introduction The United States continues to suffer from a serious epidemic of opioid use. Exposure to opioids is a known risk factor for long-term use and dependence. This is of particular importance to burn care, as opioids are frequently essential to manage the pain associated with burn injuries. The purpose of this study was to characterize opioid use among burn patients after hospitalization and to identify any risk factors for long-term dependence. Methods All patients admitted to a burn center during a single year period (2/1/2020-2/1/21) were examined. Patients who died were ex

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Lee, Rachel. "Opioid Use Disorder Industry: Role of Recent Trends in Transformation of the Sector." Clinical Case Reports and Studies 5, no. 1 (2024): 1–4. http://dx.doi.org/10.59657/2837-2565.brs.24.099.

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Opioid use disorder (OUD) is characterized as a chronic and manageable mental health condition that encompasses a problematic pattern of misusing opioids. Individuals experiencing this disorder encounter challenges in moderating or stopping their opioid usage, even when faced with problems resulting from the drug. This disorder may involve both physical and psychological dependencies. Psychological dependence occurs when a drug becomes so integral to an individual's thoughts, emotions, and behaviors that the urge to continue using it becomes a strong craving or compulsion, persisting despite a

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Sarkar, Siddharth, Mohit Varshney, Vaibhav Patil, and Rakesh Lal. "Maintainence Treatment of Opioid Dependence with Tramadol." Journal of Neurosciences in Rural Practice 08, S 01 (2017): S098—S101. http://dx.doi.org/10.4103/jnrp.jnrp_422_16.

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ABSTRACT Background: Although tramadol has been used in the management of acute withdrawal in patients with opioid dependence, its use for maintenance treatment as a harm reduction approach has not been assessed systematically. This case series describes patients with opioid dependence who were treated with tramadol for long-term maintenance. Methods: Patients with opioid dependence who received treatment at the National Drug Dependence Treatment Centre of All India Institute of Medical Sciences, New Delhi, were included in the study. Patients who received at least 6 months of tramadol and had

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Dietz, Nicholas, Mayur Sharma, Ahmad Alhourani, et al. "Preoperative and Postoperative Opioid Dependence in Patients Undergoing Anterior Cervical Diskectomy and Fusion for Degenerative Spinal Disorders." Journal of Neurological Surgery Part A: Central European Neurosurgery 82, no. 03 (2021): 232–40. http://dx.doi.org/10.1055/s-0040-1718759.

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Abstract Background Anterior cervical diskectomy and fusion (ACDF) is a procedure for effectively relieving radiculopathy. Opioids are commonly overprescribed in postsurgical settings and prescriptions vary widely among providers. We identify trends in opioid dependence before and after ACDF. Methods We used the Truven Health MarketScan data to identify adult patients undergoing ACDF for degenerative cervical spine conditions between 2009 and 2015. Patients were segregated in four cohorts of preoperative and postoperative opioid nondependence (ND) or dependence (D) with 15 months of postoperat

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Angst, Martin S., and J. David Clark. "Opioid-induced Hyperalgesia." Anesthesiology 104, no. 3 (2006): 570–87. http://dx.doi.org/10.1097/00000542-200603000-00025.

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Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although common concerns regarding the use of opioids include the potential for detrimental side effects, physical dependence, and addiction, accumulating evidence suggests that opioids may yet cause another problem, often referred to as opioid-induced hyperalgesia. Somewhat paradoxically, opioid therapy aiming at alleviating pain may render patients more sensitive to pain and potentially may aggravate their preexisting pain. This review provides a comprehensive summary of basic and clinical research concerning o

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Vineet, Kumar, Pathak Sanjay, and Gupta Vikesh. "Socio-Epidemiological Profile of Opioid Abuse Patients Presenting to Himachal Hospital of Mental Health and Rehabilitation: A Cross Sectional Study." International Journal of Research and Review 7, no. 6 (2020): 275–78. https://doi.org/10.5281/zenodo.3952329.

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According to world report‑2013 published by United Nations Office on Drug and Crime (UNODC), about 16.5 million or 0.4% of world adult population (15-64 years of age), used illicit opioids in year 2011. Dependence to opioids can lead to increased rates of morbidity and mortality secondary to different infections and it can also increase the criminal consequences for the individual using the substance as well. Although opioid‑dependence has become one of the most prevalent psychiatric illnesses during recent years a very few studies have looked into the profiles of opioid‑dependent patients in

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Evans, Christopher J., and Catherine M. Cahill. "Neurobiology of opioid dependence in creating addiction vulnerability." F1000Research 5 (July 19, 2016): 1748. http://dx.doi.org/10.12688/f1000research.8369.1.

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Opioid drugs are potent modulators of many physiological and psychological processes. When given acutely, they can elicit the signature responses of euphoria and analgesia that societies have coveted for centuries. Repeated, or chronic, use of opioids induces adaptive or allostatic changes that modify neuronal circuitry and create an altered normality — the “drug-dependent” state. This state, at least that exhibited by those maintained continuously on long-acting opioid drugs such as methadone or buprenorphine, is generally indistinguishable from the drug-naïve state for most overt behaviors.

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Suzuki, MD, Joji, Michele L. Matthews, PharmD, David Brick, BA, et al. "Implementation of a collaborative care management program with buprenorphine in primary care: A comparison between opioid-dependent patients and patients with chronic pain using opioids nonmedically." Journal of Opioid Management 10, no. 3 (2014): 159. http://dx.doi.org/10.5055/jom.2014.0204.

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Objective: To implement a collaborative care management program with buprenorphine in a primary care clinic.Design: Prospective observational study.Setting: A busy urban academic primary care clinic affiliated with a tertiary care hospital.Participants: Opioid-dependent patients or patients with chronic pain using opioids nonmedically were recruited for the study. A total of 45 participants enrolled.Interventions: Patients were treated with buprenorphine and managed by a supervising psychiatrist, pharmacist care manager, and health coaches. The care manager conducted buprenorphine inductions a

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Quintanilla, María Elena, Paola Morales, Daniela Santapau, et al. "Morphine self-administration is inhibited by the antioxidant N‐acetylcysteine and the anti-inflammatory ibudilast; an effect enhanced by their co-administration." PLOS ONE 19, no. 10 (2024): e0312828. http://dx.doi.org/10.1371/journal.pone.0312828.

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Background The treatment of opioid addiction mainly involves the medical administration of methadone or other opioids, aimed at gradually reducing dependence and, consequently, the need for illicit opioid procurement. Thus, initiating opioid maintenance therapy with a lower level of dependence would be advantageous. There is compelling evidence indicating that opioids induce brain oxidative stress and associated glial activation, resulting in the dysregulation of glutamatergic homeostasis, which perpetuates drug intake. The present study aimed to determine whether inhibiting oxidative stress a

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Hakimian, Joshua K., Tien S. Dong, Jorge A. Barahona, et al. "Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut Microbiome." Nutrients 11, no. 8 (2019): 1900. http://dx.doi.org/10.3390/nu11081900.

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Opioids are highly addictive substances with a relapse rate of over 90%. While preclinical models of chronic opioid exposure exist for studying opioid dependence, none recapitulate the relapses observed in human opioid addiction. The mechanisms associated with opioid dependence, the accompanying withdrawal symptoms, and the relapses that are often observed months or years after opioid dependence are poorly understood. Therefore, we developed a novel model of chronic opioid exposure whereby the level of administration is self-directed with periods of behavior acquisition, maintenance, and then

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Kissin, M. Ya, N. B. Khalezova, E. A. Gibitova, A. V. Tarnorutskaya, and A. N. Ivanov. "Pregabalin use in HIV-infected patients with opioid dependence syndrome." V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, no. 2 (November 11, 2018): 70–79. http://dx.doi.org/10.31363/2313-7053-2018-2-70-79.

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Te purpose of the current study was to identify an abuse potential of pregabalin in HIVinfected patients with opioid use disorder long time using pregabaline. A cross-sectional study was performed at the St. Petersburg Center for the prevention and control of HIV and infectious diseases. A cohort of 572 HIV-infected patients with opioid use disorder was examined. 96 patients (16,8% of the entire cohort) used pregabalin. 34 of them agreed to participate in the study. Te pregabalin addiction was diagnosed in 23 of 34 observed HIV-infected patients with opioid dependence. People with opioid depen

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Roberts, D. M., and M. Meyer-Witting. "High-dose Buprenorphine: Perioperative Precautions and Management Strategies." Anaesthesia and Intensive Care 33, no. 1 (2005): 17–25. http://dx.doi.org/10.1177/0310057x0503300104.

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Buprenorphine has been in clinical use in anaesthesia for several decades. Recently, the high-dose sublingual formulation (Subutex®, Reckitt Benckiser, Slough, U.K.) has been increasingly used as maintenance therapy in opioid dependence, as an alternative to methadone and other pharmacological therapies. Buprenorphine has unique pharmacological properties making it well suited for use as a maintenance therapy in opioid dependence. However, these same properties may cause difficulty in the perioperative management of pain. Buprenorphine is a partial opioid agonist, attenuating the effects of su

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Vijay, Savita, Maholi Megha, Niranjan Vijay, Mudgal Varchasvi, and Jain Priyash. "Study on Sociodemographic and Clinical Profile of Opioid Dependence Patients in a Tertiary Health Care Center in Central India." International Journal of Toxicological and Pharmacological Research 13, no. 9 (2023): 128–31. https://doi.org/10.5281/zenodo.11080488.

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<strong>Background:</strong> Abuse of opiates is a widespread issue that affects people of many nationalities worldwide. Opi-oid use and dependence have recently increased both internationally and in India. It severely affects social, psy-chological, physical, and environmental aspects of existence and complicates the law. Therefore, among other substance addiction, the rise in opioid dependence is one of the major problems. <strong>Methods:</strong> It was an observational study, which enrolled 100 patients from DTC OPD through purposive sam-pling for one year duration after fu

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Eken Sander, MD, Stephanie C., and Lon R. Hays, MD, MBA. "Prescription opioid dependence and treatment with methadone in pregnancy." Journal of Opioid Management 1, no. 2 (2005): 91. http://dx.doi.org/10.5055/jom.2005.0022.

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Prescription opioids are used medically to treat pain, but their diversion and abuse continues to escalate in the United States.1 Abuse of OxyContin (Purdue Pharma LP, Stamford, CT), a timed-release form of oxycodone, is a major focus of public health and law enforcement agencies. 2 The rise in opioid abuse may lead to an increase in opioid dependence in pregnancy, which was a focus of this study. Our retrospective chart review examined the demographics and patterns of opioid addiction of pregnant women admitted to an inpatient psychiatric unit in an academic medical center in central Kentucky

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Subramanian, Prabavathy, and Jayasri Jayamoorthy. "Opioid-dependence Syndrome." Pondicherry Journal of Nursing 12, no. 1 (2019): 13–14. http://dx.doi.org/10.5005/jp-journals-10084-12110.

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JAMES, DOMINIKA LIPOWSKA, and MARYAM JOWZA. "Treating Opioid Dependence." Clinical Obstetrics and Gynecology 62, no. 1 (2019): 87–97. http://dx.doi.org/10.1097/grf.0000000000000422.

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Galderisi, S. "In opioid dependence." European Psychiatry 17 (May 2002): 220. http://dx.doi.org/10.1016/s0924-9338(02)80941-5.

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Newman, Robert G. "Prescription Opioid Dependence." JAMA Psychiatry 71, no. 3 (2014): 338. http://dx.doi.org/10.1001/jamapsychiatry.2013.4530.

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Krantz, Mori J., and Philip S. Mehler. "Treating Opioid Dependence." Archives of Internal Medicine 164, no. 3 (2004): 277. http://dx.doi.org/10.1001/archinte.164.3.277.

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