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1

Freye, Enno, and Joseph Victor Levy. Opioids in Medicine. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-5947-6.

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2

Nagase, Hiroshi. Chemistry of Opioids. Springer-Verlag Berlin Heidelberg, 2011.

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3

Stannard, Catherine F. Opioids in non-cancer pain. Oxford University Press, 2007.

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4

Victor, Levy Joseph, ed. Opioids in medicine: A systematic and comprehensive review on the mode of action and the use of analgesics in different clinical pain states. Springer, 2008.

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5

Thomas, Laura. Global state of pain treatment: Access to medicines and palliative care. Human Rights Watch, 2011.

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6

1963-, Davies Andrew, and Fishman Scott 1959-, eds. The diagnosis and treatment of breakthrough pain. Oxford University Press, 2008.

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7

Wechsberg, Wendee M. Methadone maintenance treatment in the U.S.: A practical question and answer guide. Springer, 2007.

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8

Stannard, Cathy. Opioids for pain in Europe: Differing problems and differing solutions. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198785750.003.0042.

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Opioids remain a major advance in pain medicine, but their power comes with responsibility. The prescription of opioid medicines has become a major policy issue in all nations across Europe. In this chapter of European Pain Management we offer a brief history of the use of opioids for pain, with a focus on how the modern challenges have developed, followed by a review of opioid prescribing across Europe, compared with that in North America. The harms of opioid use are reviewed, as are the barriers to their effective use in the European context. A working example from the United Kingdom is give
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9

De Lima, Liliana, Lukas Radbruch, and Eduardo Bruera. Essential medicines for palliative care. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0003.

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The essential medicines concept developed by the World Health Organization (WHO), states that there is a list of minimum medicines for a basic health-care system, including the most efficacious, safe, and cost-effective ones for priority conditions. According to the WHO, essential medicines are those that satisfy the primary health-care needs of the population. Thus, they should always be available, affordable, and cost-effective. However, the vast majority of the global population does not have access to essential medicines. Many organizations have called on governments to adopt policies to i
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10

Natural therapies for overcoming opioid dependency: Control pain and recover from addiction with Chinese medicine, acupuncture, herbs, nutritional supplements & meditation and lifestyle practices. 2018.

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11

S, Rapaka Rao, Barnett Gene, Hawks Richard L, and National Institute on Drug Abuse., eds. Opioid peptides: Medicinal chemistry. DHHS, PHS, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, 1987.

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12

S, Rapaka Rao, Barnett Gene, Hawks Richard L, and National Institute on Drug Abuse., eds. Opioid peptides: Medicinal chemistry. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, 1986.

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13

Wiffen, Philip, Marc Mitchell, Melanie Snelling, and Nicola Stoner. Patient-specific issues. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198735823.003.0011.

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This chapter covers patient-specific issues related to children, older people, injecting drug users, and surgical patients. For children, drug pharmacokinetics and pharmacodynamics and dose calculations are reviewed. The specific concerns around adherence and also medicines licensing in children are covered. For older people, the topics include pharmacokinetics, pharmacokinetics, and medication review. Guidance is given on managing injecting drug users, especially in an in-patient setting, including a suggested regimen for titration of methadone to avoid opioid withdrawal. For surgical patient
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14

Freye, Enno. Opioids in Medicine. Springer, 2008.

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15

Buprenorphine Therapy of Opiate Addiction (Forensic Science and Medicine). Humana Press, 2002.

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16

Atkinson, Timothy, John J. Coleman, and Jeffrey Fudin. Opioid Medications. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199981830.003.0001.

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This chapter describes the dilemma of today’s chronic pain patient in the face of well-intentioned regulatory efforts to reduce opioid-related mortality. From the beginning of recorded history, there has been interest in substances derived from opium poppy. As modern governments evolved, efforts were made to ensure the availability of opiates for medicinal use while restricting their nonmedical use. This chapter discusses US efforts to control opiates and the severe problem of opiate abuse in the United States that gave rise to these efforts. The United States was the first nation to establish
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17

Sjøgren, Per, Frank Elsner, and Stein Kaasa. Non-opioid analgesics. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0096.

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Non-opioid analgesics encompass the non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol (acetaminophen). The NSAIDs include acetylsalicylic acid (ASA, aspirin), dipyrone (metamizole), and numerous other drugs in diverse classes. The NSAIDs have potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. In palliative medicine, they represent the first step of the World Health Organization’s analgesic ladder used for mild pain and they are an important supplement to opioids and adjuvant drugs at higher steps of the ladder. The dis
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18

L, Batki Steven, and Center for Substance Abuse Treatment (U.S.), eds. Medication-assisted treatement for opioid addiction in opioid treatment programs. U.S. Dept. of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, 2005.

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19

Badiola, Ignacio, Tulsi Singh, Jiabin Liu, and Nabil Elkassabany. Acute Pain in the Opioid-Tolerant Patient. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190271787.003.0045.

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The number of people addicted to prescription and illicit opioids continues to increase, and many of these patients present to the hospital or pain center with acute pain issues. The matter is further complicated by the increasing number of patients with legitimately painful conditions treated with chronic opioid therapy. Typically, these patients are difficult to manage during any acute pain episode due to their opioid tolerance and opioid-induced hyperalgesia. This difficulty often leads to inadequate pain management, increased suffering, and delayed hospital discharge. Increased awareness i
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20

Ling, Walter, and Matthew Torrington. Integrative Approach to Opiates, Opioids, and Opiate Use Disorder. Edited by Shahla J. Modir and George E. Muñoz. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190275334.003.0008.

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This chapter defines terms such as “opiate” and “opioid” and explains their physiological functions as agonist, antagonist, and partial agonist. It notes the long history of medicinal opioid use for acute pain, as well as the curse of addiction with chronic use, highlighting the three opioid use epidemics in the United States: the morphine addiction of the Civil War era, the heroin addiction of the Vietnam War era, and the current epidemic of prescription opioid addiction. The chapter describes the commonly encountered natural, synthetic, and semi-synthetic opioids, noting their therapeutic us
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21

Zhang, Weiya, and Michael Doherty. Guidelines. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0037.

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A number of treatment guidelines have been developed to optimize the treatment of osteoarthritis, some of which were recently updated. Fifty-one non-pharmacological, pharmacological, and surgical treatments are addressed in these guidelines but only two (oral opioid and intra-articular steroid injection) reach the minimal clinically important difference above placebo. Recommendations for these treatments vary depending on joint sites, risk:benefit ratio, and population. Exercise, self-management, and weight reduction if obese are universally recommended. While topical non-steroidal anti-inflam
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22

Pan, Zhizhong Z. Opioid Research: Methods and Protocols (Methods in Molecular Medicine). Humana Press, 2003.

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23

Nagase, Hiroshi. Chemistry of Opioids. Springer, 2013.

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24

Stevens, Craig W. Spinal opioid analgesia in the rat. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0020.

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It is hard to imagine a time when the world of science and medicine did not know that morphine or other opioids administered to the spinal cord produced analgesia. However, this was the current state of knowledge in the early 1970s before the studies of Yaksh and Rudy created one of the most important paradigm shifts in the treatment of pain. The landmark paper is a pharmacology paper describing the results of the first comprehensive study of spinal opioid analgesia in the rat. The study produced the first full dose-response curves for morphine, fentanyl, methadone, and meperidine and proved a
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25

Ansari, Arash, and David Osser. Psychopharmacology. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780197537046.001.0001.

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Psychopharmacology: A Concise Overview, 3rd Edition discusses and reviews currently available psychiatric medications and their evidence-supported use in current clinical practice. It discusses the therapeutic uses of antidepressants, anti-anxiety medications, antipsychotics, mood stabilizers, stimulants, and other medications for attention-deficit/hyperactivity disorder (ADHD), as well as medicines for substance use disorders. It reviews the medications’ mechanisms of action, therapeutic effects, potential drug–drug interactions and short- and long-term adverse effects and risks. It includes
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26

Eric, Braun. Big Pharma and the Opioid Epidemic: From Vicodin to Heroin. Capstone, 2020.

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27

Eric, Braun. Big Pharma and the Opioid Epidemic: From Vicodin to Heroin. Capstone, 2020.

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28

Eric, Braun. Big Pharma and the Opioid Epidemic: From Vicodin to Heroin. Capstone, 2020.

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29

Big Pharma and the Opioid Epidemic: From Vicodin to Heroin. Capstone, 2020.

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30

Collier, Devina Hughes. Armor Of God: Alternative Medicine Keys To Recovery From Opioid Addiction. Divine Natural Solutions - Private Healthcare Membership Association, 2018.

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31

The American Society of Addiction Medicine Handbook on Pain and Addiction. Oxford University Press, 2018.

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32

Peppin, John F., Kelly K. Dineen, Adam J. Ruggles, and John J. Coleman, eds. Prescription Drug Diversion and Pain. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199981830.001.0001.

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Prescription Drug Diversion and Pain provides an interdisciplinary overview of medications used to treat chronic pain, and the benefits and risks that are posed by long-term use of opioids. Use of these life-saving medications must be carefully managed to prevent serious side effects, which may include physical dependence, addiction, and even death. In recent years, the risk of these side effects has led to increased attention on the development of alternative treatments for chronic pain. This book not only offers a single, comprehensive source for understanding the specialized nature of the o
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33

Opioids in Non-Cancer Pain. Oxford University Press, 2013.

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34

Pickering, Anthony, Cathy Stannard, and Micheal H. Coupe. Opioids in Non-Cancer Pain (Oxford Pain Management Library Series). Oxford University Press, USA, 2008.

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35

Fentanyl, Inc: How Rogue Chemists Are Creating the Deadliest Wave of the Opioid Epidemic. Cengage Gale, 2020.

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36

Breaking The Cycle Of Opioid Addiction: Supplement Your Pain Management with Cannabis. North Atlantic Books, 2018.

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37

(Editor), Halina Machelska, and Christoph Stein (Editor), eds. Immune Mechanisms of Pain and Analgesia (Advances in Experimental Medicine and Biology). Springer, 2003.

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38

Schatman, Michael E., and Oscar J. Benitez. Adherence in Pain Medicine. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190600075.003.0007.

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This chapter reviews adherence to treatment options in pain medicine from the clinician’s point of view. Adherence is discussed in the context of principle-based ethics through the four tenets of autonomy, nonmaleficence, beneficence, and justice. Treatment adherence for pain medicine on the part of the clinician transcends mere compliance with opioid prescriptions and policies. Adherence is addressed as a broad-based approach that can be clinically appropriate when principle-based ethics are followed. The shortage of clinical therapists and the corresponding role of clinical psychologists are
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39

Buckenmaier, Chester C., Michael Kent, Jason C. Brookman, Patrick J. Tighe, Edward R. Mariano, and David Edwards, eds. Acute Pain Medicine. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190856649.001.0001.

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Acute Pain Medicine tackles a large array of diagnostic and treatment consideration across a variety of surgical and nonsurgical acute pain conditions. It reviews a variety of acute pain–modulating factors followed by interventional and pharmacologic treatment options. For each applicable condition, perineural and neuraxial considerations are given when appropriate along with nociceptive anatomic complements. Pharmacologic modalities are described, stressing the use of multimodal analgesia and a variety of opioid-based options if necessary. The book reviews cases that commonly are associated w
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40

Gourlay, Douglas L., and Howard A. Heit. The Use of Drug Testing in Promoting Treatment Adherence in Pain Medicine. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190600075.003.0004.

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Drug testing has become an important component of a comprehensive risk assessment and mitigation program when prescribing controlled substances to patients with chronic pain. State and federal opioid prescribing guidelines strongly recommend the use of drug testing, although there is lack of evidence in the literature supporting the efficacy of drug testing in reducing prescription opioid abuse. Drug testing can be useful in facilitating adherence to prescribed medications. This chapter provides an overview of the strengths and weaknesses of drug testing in pain medicine, insights into laborat
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41

Schatman, Michael E. The Demise of Interdisciplinary Chronic Pain Management and Its Relationship to the Scourge of Prescription Opioid Diversion and Abuse. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199981830.003.0010.

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Even though the efficacy of interdisciplinary pain management programs is supported, their numbers have decreased and the vast majority of Americans with chronic pain do not have access to them. Insurance companies do not want to pay for these services, hospitals believe they are financial losers, and the opioid crisis has placed a pall over the practice of pain medicine. The demise of these programs has left pain medicine in a fragmented state. Few healthcare providers who treat chronic pain patients have the time to coordinate care by multiple professionals The opioid crisis seen in certain
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42

Harrison, Mark. Central nervous system. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0041.

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This chapter describes the pharmacology of the central nervous system as it applies to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details of hypnotics and anxiolytics, antipsychotics, antimania drugs, tricyclic antidepressants, nausea and vomiting, analgesics, non-opioid analgesics, opioid analgesics, antiepileptics, and status epilepticus. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.
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43

Andraka-Christou, Barbara. Opioid Fix: America's Addiction Crisis and the Solution They Don't Want You to Have. Johns Hopkins University Press, 2020.

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44

Andraka-Christou, Barbara. Opioid Fix: America's Addiction Crisis and the Solution They Don't Want You to Have. Johns Hopkins University Press, 2020.

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45

Dean, Reginald, Edward J. Bilsky, and S. Stevens Negus. Opiate Receptors and Antagonists: From Bench to Clinic. Humana, 2010.

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46

Opiate Receptors and Antagonists: From Bench to Clinic (Contemporary Neuroscience). Humana Press, 2008.

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47

Rastegar, Darius, and Michael I. Fingerhood, eds. ASAM Handbook of Addiction Medicine. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780197506172.001.0001.

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This book is a concise, evidence-based guide to the treatment of individuals with substance use disorders. It is an update to the 2015 edition and is targeted to nonspecialist clinicians who want to better care for their patients with substance use disorders. It begins with chapters on screening and brief intervention and an overview of treatment. This is followed by substance-specific chapters covering the following topics: alcohol, sedatives, opioids, nicotine, stimulants, hallucinogens, cannabinoids, inhalants, anabolic steroids, and prescription drugs. Substance-specific chapters cover pha
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48

Dalrymple, Theodore. Romancing Opiates: Pharmacological Lies and the Addiction Bureaucracy. Encounter Books, 2006.

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49

Gibbs, Margaret. The contribution of the clinical pharmacist in palliative care. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0414.

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The inclusion of a pharmacist in the palliative care team is becoming appreciated and widespread. Effective medicines management can improve patient outcomes and have financial benefits for organizations. Most patients prefer to spend as much time as possible at home so pharmacist input in the community is especially crucial in ensuring they receive their medicines and have information to support them in taking them. Palliative care normally involves using strong opioids and the legal requirements surrounding their use can be complex. Pharmacists have detailed knowledge in this area so can adv
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50

The Making of Addiction: The 'use and Abuse' of Opium in Nineteenth-century Britain (The History of Medicine in Context) (The History of Medicine in Context). Ashgate Publishing, 2007.

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