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Dissertations / Theses on the topic 'Opioidní receptor'

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Published: 4 June 2021
Last updated: 18 February 2022

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1

Zhang, Shengwen. "The opioid receptor-like receptor ORL1 signaling and interaction with opioid receptors /." Cincinnati, Ohio : University of Cincinnati, 2002. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1029419843.

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2

ZHANG, SHENGWEN. "THE OPIOID RECEPTOR-LIKE RECEPTOR ORL1: SIGNALING AND INTERACTION WITH OPIOID RECEPTORS." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029419843.

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3

Rudén, Ludvig. "Neurobiology of opioid addiction." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15735.

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Since the use of opioids started to emerge for analgesic reasons in the 19th century with the synthetization of morphine, opioids have been studied rigorously to better understand its effects on the brain. This thesis shows that both the analgesic effects and the reinforcing effects of opioids are mediated by the same receptor, the mu opioid receptor (MOR). MOR activity has been correlated to both primary and secondary reinforcers and should be considered to cause positive reinforcement together with increases in dopamine transmission for all drugs of abuse, and not only in relation to opioids
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4

Martínez, Navarro Miriam 1990. "Affective disorders and neuropathic pain as mutually influential factors : contribution of the opioid system." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/665963.

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La alta variabilidad interindividual en las manifestaciones de dolor neuropático puede conducir a una respuesta diferencial de los pacientes a los tratamientos, y sugiere la idoneidad de terapias más personalizadas en lugar de pautas generales. En esta tesis hemos estudiado en primer lugar la influencia de los rasgos conductuales en las manifestaciones del dolor neuropático crónico utilizando aproximaciones conductuales, electrofisiológicas y genéticas. El sistema opioide endógeno es una diana terapéutica crucial para el tratamiento del dolor inflamatorio y nociceptivo moderado o intenso. Sin
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5

Nascimento, Ana Isabel Reis. "Participação dos receptores delta e kappa -opioides centrais no controle do apetite por sódio em ratos estimulados a ingerir solução salina hipertônica." reponame:Repositório Institucional da FIOCRUZ, 2015. https://www.arca.fiocruz.br/handle/icict/11934.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2015-10-13T12:34:40Z No. of bitstreams: 1 Ana Isabel Reis Nascimento. Participação...2015.pdf: 1631129 bytes, checksum: d14aa063c882bb96ee29f85751abf2e6 (MD5)<br>Approved for entry into archive by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2015-10-13T12:34:59Z (GMT) No. of bitstreams: 1 Ana Isabel Reis Nascimento. Participação...2015.pdf: 1631129 bytes, checksum: d14aa063c882bb96ee29f85751abf2e6 (MD5)<br>Made available in DSpace on 2015-10-13T12:34:59Z (GMT). No. of bitstreams: 1 Ana Isabel Reis Nascimento. Parti
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6

Szekeres, Philip Graham. "Studies on the activation of G proteins by opioid receptors and receptor-mimetic peptides." Thesis, Loughborough University, 1995. https://dspace.lboro.ac.uk/2134/12440.

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7

Yoo, Ji Hoon. "Receptor studies in opioid receptor and opioid peptide gene knockout mice." Thesis, University of Surrey, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493210.

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is postulated that dynorphin inhibits the cocaine-induced increase in striatal dopamine levels, that may contribute to dynorphin's ability to prevent cocaine induced conditioned place preference and to attenuate an increase in locomotor activity. In this thesis interactions between dynorphin and the dopaminergic system in cocaine addiction have been addressed using preprodynorphin gene knockout mice treated with a chronic "binge" cocaine protocol.
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8

Olson, Keith Mathew, and Keith Mathew Olson. "Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/626669.

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Most clinical opioids produce analgesia through the Mu Opioid Receptor (MOR) providing the only effective treatment for chronic pain patients. These studies explore three pre-clinical strategies to improve MOR analgesia and minimize side effects: 1) compounds that target G-protein Coupled Receptors (GPCRs) heterodimers, such as heterodimerization between the Delta Opioid Receptor (DOR) and MOR (MDOR); 2) multi-functional compounds that target multiple receptor systems for synergistic effects, such as a MOR agonist and a the serotonin reuptake transporter (SERT) inhibitor; or 3) biased agonists
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9

Macedo, Cristina Gomes de 1964. "Mecanismos opióides centrais envolvidos no efeito protetor da testosterona no desenvolvimento da dor da ATM em ratos." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290572.

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Orientador: Claudia Herrera Tambeli<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-20T01:36:46Z (GMT). No. of bitstreams: 1 Macedo_CristinaGomesde_M.pdf: 777542 bytes, checksum: 9fba5bed6fd851b4349bf4812dda8d33 (MD5) Previous issue date: 2012<br>Resumo: Disfunções temporomandibulares são condições dolorosas que envolvem a articulação temporomandibular e os músculos mastigatórios com maior prevalência, severidade e duração no sexo feminino. Recentemente foi demonstrado que a testosterona apresenta um
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10

Smith, Caroline Jackson. "Development of oxytocin, vasopressin V1a, and mu-opioid receptor expression in the rat brain: Implications for the regulation of juvenile social novelty-seeking behavior." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107311.

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Thesis advisor: Alexa H. Veemena<br>Across species, the juvenile period is characterized by increased social interaction with peers and heightened novelty-seeking behavior, as compared to any other life stage. These behaviors are likely to be highly adaptive during this developmental phase. Still, an excessive novelty-seeking phenotype may predispose individuals to risk-taking and substance abuse, while too little social engagement and low novelty-seeking are characteristics of neuropsychiatry disorders such as autism. The over-arching aim of this dissertation research has been to elucidate th
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11

Rosa, Expósito Mònica. "Disseny racional de lligands del receptor opioide i d’anàlegs d’opiorfina." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/128663.

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L'estructura cristal•logràfica del receptor opioide ha estat una gran incògnita fins al seu recent descobriment. En aquesta tesi s'han realitzat aportacions al disseny racional de fàrmacs opioides, mitjançant la posada a punt de tècniques d'anàlisi proteòmica del receptor opioide i amb estudis de la seva interacció amb lligands peptídics endògens (encefalines i endorfines) i els seus anàlegs, per interpretar millor les conformacions dels lligands i el seu mode d'unió al centre actiu. D'altra banda, s'han realitzat estudis de nous inhibidors dels enzims que degraden les encefalines (Endopept
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12

Robichon, Alain. "Photoaffinité des récepteurs opioides U et D et du récepteur au VIP (vasoactive intestinal peptide)." Paris 6, 1987. http://www.theses.fr/1987PA066605.

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13

Navratilova, Edita. "Regulation of the human delta opioid receptor." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194173.

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Regulation of the human delta opioid receptor (hDOR) is implicated in the development of tolerance to chronic morphine (Zhu et al., 1999). In addition, DORs are promising analgesic targets for the management of chronic pain states such as inflammatory or neuropathic pain (Cahill et al., 2007). Therefore, in this study, we investigated multiple aspects of hDOR regulation, including receptor phosphorylation, beta-arrestin binding, receptor internalization, down-regulation and desensitization, using recombinant Chinese hamster ovary (CHO) cells expressing the wild-type or various mutant hDOR cons
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14

Lu, Yu. "Ligands for the sigma receptor and the mu-opioid receptor." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4961.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on January 4, 2008) Includes bibliographical references.
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15

Mazahery, Claire. "CD8+ T Cell Mediated Immunity is Disrupted by Ex Vivo and In Vivo Opioid Use." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1587376234022407.

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16

Morinville, Anne. "Awakening the [delta]ormant receptor : interactions between [mu] and [delta] opioid receptors in vitro and in vivo." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84298.

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Opioid drugs acting at the mu opioid receptor (muOR), such as morphine, represent the most commonly prescribed analgesics for the clinical management of moderate to severe pain. However, the clinical use of muOR agonists is limited by the occurrence of undesirable effects such as respiratory depression and the tendency to produce tolerance and/or dependence with repeated administration. delta opioid receptor (deltaOR) activation produces antinociception with reportedly less deleterious effects when compared to muOR activation. However, animal studies have revealed that deltaOR-mediated
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17

Clarke, Sian. "Quantitative receptor autoradiography in opioid peptide and receptor knockout mice." Thesis, University of Surrey, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368377.

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18

Tumati, Suneeta. "Functional regulation of opioid receptor signaling." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194989.

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Studies have shown that long-term opioid agonist (such as morphine) treatment produces antinociceptive tolerance and increased pain sensitivity (hyperalgesia and/or allodynia), limiting the clinical efficacy of morphine. Prolonged opiate administration also upregulates spinal pain neurotransmitter (such as calcitonin gene-related peptide (CGRP)) levels and enhances evoked CGRP release in the dorsal horn of rats. It was suggested that augmented spinal pain neurotransmission may contribute to paradoxical pain sensitization and antinociceptive tolerance. The cellular signal transduction pathways
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19

Baptist, Myma Cynthia. "Studies of μ-opioid receptor internalisation". Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520291.

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ELISAs were used to investigate the effects of a range of opioid ligands on the internalisation of the T7-tagged μ-opioid receptor (MOR) expressed in HEK 293 cells. The different opioid ligands were seen to vary in their abilities to induce MOR internalisation. The effect of the MOR agonists, DAMGO and morphine on MOR phosphorylation mutants (MOR-T180A and MOR-S363A) expressed in HEK 293 cells was also examined by ELISA. The ability of DAMGO to induce internalisation was significantly inhibited in the MOR-T180A in comparison to the wild type MOR. An N-terminal superecliptic pHluorin-tagged μ-o
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20

Ho, M. T. B. "Pharmacology of the orphan opioid receptor." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604104.

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The neuropeptide nociceptin/orphanin FQ (OFQ) was recently identified as the endogenous agonist of the orphan opioid receptor ORL<SUB>1</SUB>. In this thesis pharmacological studies on the ORL<SUB>1</SUB> receptor were advanced by the comparison of the potencies and efficacies of several ligands at the rat ORL<SUB>1</SUB> receptor stably transfected into chinese hamster ovary (CHO) cells, with those at the native receptor in the central (frontal cortex) and peripheral (anococcygeus muscle) nervous systems. Most notably, the work involved a close examination of the pharmacology of the first sel
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21

Johnson, Elizabeth Alice. "μ-opioid receptor desensitization and internalization." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424064.

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22

Kovoor, Abraham. "Molecular regulation of opioid receptors /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6278.

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23

Altarifi, Ahmad. "EFFECTS OF MU OPIOID RECEPTOR AGONISTS ON INTRACRANIAL SELF-STIMULATION IN THE ABSENCE AND PRESENCE OF “PAIN” IN RATS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/518.

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Pain is a significant health problem. Mu opioid receptor agonists are used clinically as analgesics, but their use is constrained by high abuse liability. Intracranial self-stimulation (ICSS) is a preclinical behavioral procedure that has been used to assess abuse potential of opioids, and drug-induced facilitation of ICSS is interpreted as an abuse-related effect. ICSS can also be used as a behavioral baseline to detect affective dimensions of pain. Specifically, pain-related depression of ICSS can model pain-related depression of behavior and mood, and drug-induced blockade of pain-related
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24

Zhang, Weimin, and 張為民. "Cardiac k-opioid receptor: multiplicity, regulation, signal transduction and function." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B3123804X.

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25

Bochet, Pascal. "Marquage des recepteurs opioides delta dans le systeme nerveux central du rat." Paris 6, 1988. http://www.theses.fr/1988PA066089.

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26

Saxena, Kunal. "Arrestin interactions with the μ-opioid receptor". Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559233.

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Upon agonist binding the u-opioid receptor (MOPr) is phosphorylated and can recruit arrestin-2 (beta-arrestin-l) and arrestin-3 (p-arrestin-2). Apart from promoting the desensitization and intemalization of the MOPr, the binding of arrestins can also lead to the triggering of alternative sigvalling pathways. It has been shown that kinases including GRK2, PKC and CaMKII can regulate MOPr. Here we used GST -fusion constructs of the intracellular regions of MOPr to investigate whether arrestin-2 and -3 can bind to these sequences in vitro, and secondly to determine whether phosphorylation of thes
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27

Pillinger, Kathryn. "New antagonists for the Kappa Opioid receptor." Thesis, University of Bath, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501626.

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There has been much evidence in recent years to suggest that the kappa opioid receptor plays a significant role in mediating a number of behavioural disorders including drug abuse and depression. Previous in vitro evaluation within the group of secondary and tertiary amines derived from 2-amino-1,1-dimethyl-1,2,3,4-tetrahydronaphthalen-7-ol has suggested that all behave as pure opioid antagonists. These findings prompted further synthetic and pharmacological investigations of this scaffold, with the eventual aim of developing a short-acting selective kappa opioid antagonist to further probe th
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28

Raehal, Kirsten M. "Opioid-induced side effects in beta-arrestin2 and G protein-coupled receptor kinase knockout mice." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1236884585.

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29

Heyman, Julius Scott. "Antinociceptive actions of central opioid delta receptors." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184918.

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Opioids produce myriad effects, perhaps the most clinically relevant of which is the relief of pain. The understanding of the functions mediated by opioid systems is complicated greatly by the presence of several opioid receptor types. Understanding the functions associated with specific opioid receptors may lead to the development of receptor selective drugs which elicit only desirable effects. This dissertation addresses the possibility that supraspinal and spinal opioid δ receptors mediate and/or modulate thermal antinociceptive processes in the mouse. A number of approaches were utilized i
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30

Lui, Wan Thomas, and 雷雲. "Biochemical events induced by the specific kappa-opioid receptor agonist, U50488H." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011345.

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31

Chiu, Yi-Ting. "STUDIES ON NEURITE OUTGROWTH AND RECEPTOR PHOSPHORYLATION FOLLOWING KAPPA OPIOID RECEPTOR ACTIVATION." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/384383.

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Pharmacology<br>Ph.D.<br>Kappa opioid receptor (KOPR) is involved in many physiological functions and pharmacological responses such as analgesia, anti-pruritic effect, sedation, motor incoordination and aversion (Simonin et al., 1998; Liu-Chen, 2004). The cellular mechanisms following activation of KOPR involve in part Gi/o protein-dependent pathways (Law et al., 2000). Following KOPR activation, the receptor is phosphorylated and arrestins are recruited. Arrestins mediate agonist-dependent KOPR desensitization, internalization and down-regulation (Liu-Chen, 2004). In recent years, arrestins
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32

Oakley, Sarah M. "The influence of G-protein coupling of the #delta#-opioid receptor on the activity of #delta#-opioid receptor ligands." Thesis, University of Surrey, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326816.

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33

Arnatt, Christopher Kent. "DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/517.

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The chemokine receptor CCR5 (CCR5) plays an integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists. Within this work, CCR5’s role in prostate cancer and HIV/AIDS has been exploited in order to develop potential therapeutics and probes. First, a series of novel compounds was designed by using pharmacophore-based drug design based upon known CCR5 antagonists and molecular modeling studies of the CCR5 receptor’s three-dimensional conformation. Once synthesized, these compounds were t
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34

Lui, Wan Thomas. "Biochemical events induced by the specific kappa-opioid receptor agonist, U50488H /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38284157.

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35

Bennett, Ryan. "Association Tests of the Opioid Receptor System and Alcohol-Related Traits." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1993.

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The opioid receptors and their endogenous ligands have long been implicated in a variety of traits including addiction, impulsive behaviors and substance dependence. Using phenotypic measurements collected from the IASPSAD, data from a latent class analysis and data from a SNP array and additional genotyping assays, association and regression tests were performed to determine the effects of common SNPs encoded in the genes of the opioid receptors and ligands on various traits relating to alcohol dependence. Although only one SNP can be reported as significant for substance dependence within
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36

Bell, Katrina Margaret. "A biochemical and pharmacological characterisation of some endogenous and exogenous κ opioid ligands". Thesis, Loughborough University, 1994. https://dspace.lboro.ac.uk/2134/12053.

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An investigation of the interaction of stable opioid/ligands and unstable opioid peptides with opioid receptors in guinea pig brain, guinea pig myenteric plexus and mouse vas deferens has been carried out. The initial aim of the study was to further characterise K opioid receptors, using binding assays and isolated tissue bioassays. The second aim was to determine the true affinity and potency of small dynorphin peptides for the K opioid receptor and to determine if metabolism of the peptides to non K opioid receptor-preferring products contributes to their observed in vitro pharmacology.
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37

Galzi, Jean-Luc. "Synthese de sondes photoactivables et marquage irreversible du recepteur des opioides." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13114.

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38

Sanyathitiseree, Pornchai. "Opioid receptors in the chicken brain." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=978233581.

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39

Vieira, Ãngela MagalhÃes. "EFFECTIVENESS OF AQUEOUS EXTRACT OF Maytenus rigida Mart. (CELASTRACEAE) IN ETHANOL-INDUCED DAMAGE GASTRIC IN MICE: ANALYSIS OF INVOLVEMENT OF NITRIC OXIDE, PROSTAGLANDINS, OPIOIDS RECEPTORS AND α-2-ADRENERGICS." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9760.

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FundaÃÃo de Amparo à Pesquisa do Estado do CearÃ<br>Maytenus rigida Mart. (Celastraceae) pupularly known as âbom-homemâ, âbom-nomeâ, âCabelo de Negroâ, âCasca-grossaâ, ChapÃu de couroâ or âpau-de-colherâ is a native species in the northeast region of Brazil, used in folk medicine in the tratament of inflammatory diseases, gastrointestinal disorders such diarrhea, dysentery and ulcers, kidney problems, hypertension, impotence and rheumatism. The aim of this work was to demonstrate the possible mechanism (s) of action underlying the gastroprotective effect of aqueous extract (AE) of Maytenus rig
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40

Marinova, Zoya. "Opioid and non-opioid activities of the dynorphins /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-593-3/.

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41

Johansson, Anna. "Dependence-induced changes in opioid-receptor gene expression." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90034.

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Using drugs such as alcohol and morphine among others can be addictive in some individuals, and progress into a substance abuse disorder. The mesolimbic dopaminergic system (MD-system) is involved in the reward process during the development of drug addiction. The MD-system is critical for survival and affects different behaviors in both man and animal. Neurochemical pathways drive for instance physical activity, food intake, love and reproduction and are part of the natural reward process involved partly in the release of dopamine (DA) into frontal lobes. Within the MD-system opioid receptors
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42

Fischer, Bradford D. Dykstra Linda A. "Interactions between opioid agonists and glutamate receptor antagonists." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1694.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Psychology Behavioral Neuroscience." Discipline: Psychology; Department/School: Psychology.
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43

Wild, Kenneth Douglas. "Pharmacology of opioid delta and kappa receptor subtypes." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186489.

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The central hypothesis of this dissertation is that agonists acting at opioid δ or κ (but not μ) receptors may be useful for the production of effective pain relief with decreased incidence of side-effects, as well as for the possible treatment of drug-addiction. This dissertation focused on differentiating subtypes of the δ as well as the κ opioid receptor to provide selective targets for drug-development. Studies of the opioid δ receptor in vivo indicated that agonists at opioid δ receptor subtypes (δ₁ and δ₂) may produce antinociception via activation of different second messenger pathways.
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44

Soohoo, Amanda L. "Self-Controlled Regulation of Mu Opioid Receptor Trafficking." Research Showcase @ CMU, 2015. http://repository.cmu.edu/dissertations/565.

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Our cells rely extensively on external signals for key cellular and systematic functions. Many of these signals take the form of small molecules that are recognized by receptors on the cell surface. G-protein coupled receptors (GPCRs) are the largest group of surface signaling receptors. GPCRs respond to a diverse array of signals including: light, pain, adrenaline and serotonin. The capability of a certain type of GPCR to receive its signals is dependent on the number of receptors on the cell surface available to receive that extracellular signal. Intracellular trafficking determines the surf
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45

Bunn, Stephen J. "Opioid receptor distribution in rodent brain and pituitary." Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/37648.

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46

Tejeda, Hugo Alejandro. "Prefrontal kappa-opioid receptor regulation of local neurotransmission." Thesis, University of Maryland, Baltimore, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3608650.

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<p> Kappa-opioid receptors (KORs) are mediators of motivational processes, mood/emotion, and stress reactivity. KORs are enriched in brain regions that mediate such behaviors, including the medial prefrontal cortex (mPFC). The mPFC guides behavior through its connections with limbic brain regions such as the amygdala, hippocampus, and ventral tegmental area. A critical knowledge gap exists in our understanding of the role of KOR systems in modulating mPFC afferents. Thus, we designed a series of studies to understand the role of KORs in regulating dopamine (DA) and limbic glutamatergic afferen
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47

Williams, Ian Andrew. "Investigation of aminotetralins as novel opioid receptor antagonists." Thesis, University of Bath, 2006. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438651.

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48

Hartung, Alyssa Michelle. "Potential opioid receptor modulators derived from novel stilbenes." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/3093.

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The stilbene structure is part of many biologically active natural products, and these compounds can be attractive targets for chemical synthesis. A convergent synthetic design can be utilized in order to install the central olefinic moiety by way of organophosphorus compounds. This design has been employed to prepare a number of natural products, including the potent anti-cancer compounds known as the schweinfurthins and many analogues thereof. Not only do all these structures consist of a stilbenoid scaffold, but all are partially terpenoid in nature as well. Striking similarities to the sch
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49

DiMattio, Kelly Marie. "Studies on Ligands of the Kappa Opioid Receptor." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/334919.

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Pharmacology<br>Ph.D.<br>This thesis is comprised of three parts. In the first part, we investigated zyklophin, a novel selective short-acting kappa opioid receptor (KOPR) antagonist, and its effects on scratching behaviors in Swiss-Webster mice. We investigated whether zyklophin was able to induce scratching in a dose-dependent fashion, and whether this scratching behavior could be blocked by pretreatment with nor-binaltorphimine (norBNI). We also used KOPR -/- mice to further clarify the role of the KOPR in this behavior. In the second part, we examined the role of the divergent amino acid a
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50

Bilsky, Edward James 1967. "Studies on opioid delta receptor mediated antinociception, opioid antinociceptive tolerance and physical dependence." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282311.

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The central hypothesis of this dissertation is that agonists and antagonists acting at the delta opioid receptor will have therapeutic applications in treating acute and chronic pain states and in the treatment of drug addiction. It is further hypothesized that delta compounds will have better therapeutic profiles than currently available opioids that act predominantly at the mu receptor. In advancing the central hypothesis, selective nonpeptidic delta compounds, that readily cross the blood brain barrier after systemic administration, were tested. BW373U86, a nonpeptidic ligand with moderate
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