Relevant bibliographies by topics / Optical coherence tomography and confocal microscopy

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Optical coherence tomography and confocal microscopy'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Optical coherence tomography and confocal microscopy"

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Izatt, Joseph A., Manish Kulkarni, Hsing-Wen Wang, and Michael V. Sivak. "Optical Coherence Microscopy: A New Technique for High-Resolution, Non-Invasive Imaging in Bulk Biological Tissues." Microscopy and Microanalysis 3, S2 (1997): 795–96. http://dx.doi.org/10.1017/s1431927600010862.

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Optical coherence microscopy (OCM) is a novel technique complementary to optical coherence tomography (OCT) which combines low-coherence interferometry with confocal microscopy to achieve micron-scale resolution imaging in highly scattering media. OCM may be implemented using a single-mode fiber-optic low-coherence interferometer (See Fig. 1). A high numerical aperture objective is used to focus sample-arm light into the specimen, and the reference arm length of the interferometer is adjusted to match the sample arm focal plane optical depth. The sample arm of the interferometer comprises a scanning confocal microscope, in which either the sample or the probe beam is laterally scanned in a raster pattern, and the optical fiber acts as a single-mode confocal aperture for combined light illumination and collection. The reference arm length of the interferometer establishes the depth position of an interferometric “coherence gate” in the sample, from which backscattered light is preferentially collected. Initial studies of OCM in scattering phantoms have demonstrated that this technique provides increased optical sectioning depth compared to confocal microscopy alone.
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Bohn, Sebastian, Karsten Sperlich, Heinrich Stolz, Rudolf F. Guthoff, and Oliver Stachs. "In vivo corneal confocal microscopy aided by optical coherence tomography." Biomedical Optics Express 10, no. 5 (2019): 2580. http://dx.doi.org/10.1364/boe.10.002580.

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WYLEGALA, E. "Confocal microscopy and optical coherence tomography imaging of corneal dystrophies." Acta Ophthalmologica 92 (August 20, 2014): 0. http://dx.doi.org/10.1111/j.1755-3768.2014.3635.x.

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Dadkhah, Arash, and Shuliang Jiao. "Integrating photoacoustic microscopy, optical coherence tomography, OCT angiography, and fluorescence microscopy for multimodal imaging." Experimental Biology and Medicine 245, no. 4 (2020): 342–47. http://dx.doi.org/10.1177/1535370219897584.

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We have developed a multimodal imaging system, which integrated optical resolution photoacoustic microscopy, optical coherence tomography, optical coherence tomography angiography, and confocal fluorescence microscopy in one platform. The system is able to image complementary features of a biological sample by combining different contrast mechanisms. We achieved fast imaging and large field of view by combining optical scanning with mechanical scanning, similar to our previous publication. We have demonstrated the capability of the multimodal imaging system by imaging a mouse ear in vivo. Impact statement Photoacoustic microscopy-based multimodal imaging technology can provide high-resolution complementary information for biological tissues in vivo. It will potentially bring significant impact on the research and diagnosis of diseases by providing combined structural and functional information.
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Dalton, Kristine, Simone Schneider, Luigina Sorbara, and Lyndon Jones. "Confocal microscopy and optical coherence tomography imaging of hereditary granular dystrophy." Contact Lens and Anterior Eye 33, no. 1 (2010): 33–40. http://dx.doi.org/10.1016/j.clae.2009.09.005.

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Csuka, Ella A., Suzanne C. Ward, Chloe Ekelem, David A. Csuka, Marco Ardigò, and Natasha A. Mesinkovska. "Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis." Lasers in Surgery and Medicine 53, no. 6 (2021): 776–97. http://dx.doi.org/10.1002/lsm.23386.

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Tardif, Pier-Luc, Marie-Jeanne Bertrand, Maxime Abran, et al. "Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy." International Journal of Molecular Sciences 17, no. 12 (2016): 2110. http://dx.doi.org/10.3390/ijms17122110.

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Iftimia, Nicusor, R. Daniel Ferguson, Mircea Mujat, et al. "Combined reflectance confocal microscopy/optical coherence tomography imaging for skin burn assessment." Biomedical Optics Express 4, no. 5 (2013): 680. http://dx.doi.org/10.1364/boe.4.000680.

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Kang, Dongkyun, Melissa J. Suter, Caroline Boudoux, et al. "Combined Reflection Confocal Microscopy and Optical Coherence Tomography Imaging of Esophageal Biopsy." Gastrointestinal Endoscopy 69, no. 5 (2009): AB368. http://dx.doi.org/10.1016/j.gie.2009.03.1101.

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Gibson, Emily A., Omid Masihzadeh, Tim C. Lei, David A. Ammar, and Malik Y. Kahook. "Multiphoton Microscopy for Ophthalmic Imaging." Journal of Ophthalmology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/870879.

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We review multiphoton microscopy (MPM) including two-photon autofluorescence (2PAF), second harmonic generation (SHG), third harmonic generation (THG), fluorescence lifetime (FLIM), and coherent anti-Stokes Raman Scattering (CARS) with relevance to clinical applications in ophthalmology. The different imaging modalities are discussed highlighting the particular strength that each has for functional tissue imaging. MPM is compared with current clinical ophthalmological imaging techniques such as reflectance confocal microscopy, optical coherence tomography, and fluorescence imaging. In addition, we discuss the future prospects for MPM in disease detection and clinical monitoring of disease progression, understanding fundamental disease mechanisms, and real-time monitoring of drug delivery.
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Dissertations / Theses on the topic "Optical coherence tomography and confocal microscopy"

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Risi, Matthew D. "Advances In Combined Endoscopic Fluorescence Confocal Microscopy And Optical Coherence Tomography." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/332772.

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Confocal microendoscopy provides real-time high resolution cellular level images via a minimally invasive procedure. Results from an ongoing clinical study to detect ovarian cancer with a novel confocal fluorescent microendoscope are presented. As an imaging modality, confocal fluorescence microendoscopy typically requires exogenous fluorophores, has a relatively limited penetration depth (100μm), and often employs specialized aperture configurations to achieve real-time imaging in vivo. Two primary research directions designed to overcome these limitations and improve diagnostic capability are presented. Ideal confocal imaging performance is obtained with a scanning point illumination and confocal aperture, but this approach is often unsuitable for real-time, in vivo biomedical imaging. By scanning a slit aperture in one direction, image acquisition speeds are greatly increased, but at the cost of a reduction in image quality. The design, implementation, and experimental verification of a custom multi-point-scanning modification to a slit-scanning multi-spectral confocal microendoscope is presented. This new design improves the axial resolution while maintaining real-time imaging rates. In addition, the multi-point aperture geometry greatly reduces the effects of tissue scatter on imaging performance. Optical coherence tomography (OCT) has seen wide acceptance and FDA approval as a technique for ophthalmic retinal imaging, and has been adapted for endoscopic use. As a minimally invasive imaging technique, it provides morphological characteristics of tissues at a cellular level without requiring the use of exogenous fluorophores. OCT is capable of imaging deeper into biological tissue (~1-2 mm) than confocal fluorescence microscopy. A theoretical analysis of the use of a fiber-bundle in spectral-domain OCT systems is presented. The fiber-bundle enables a flexible endoscopic design and provides fast, parallelized acquisition of the optical coherence tomography data. However, the multi-mode characteristic of the fibers in the fiber-bundle affects the depth sensitivity of the imaging system. A description of light interference in a multi-mode fiber is presented along with numerical simulations and experimental studies to illustrate the theoretical analysis.
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Makhlouf, Houssine. "Integrated Multi-Spectral Fluorescence Confocal Microendoscope and Spectral-Domain Optical Coherence Tomography Imaging System for Tissue Screening." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/202761.

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A multi-modality imaging system intended for clinical utilization has been developed. It is constructed around an existing fiber-bundle-based fluorescence confocal microendoscope. Additional imaging modalities have been implemented to expand the capabilities of the system and improve the accuracy of disease diagnosis. A multi-spectral mode of operation is one such modality. It acquires fluorescence images of a biological sample across a spectral range of sensitivity and explores the collected image data at any specified wavelength within that spectral range. Cellular structures can be differentiated according to their spectral properties. The relative distribution and concentration of the different cellular structures can potentially provide useful pathologic information about the imaged tissue. A spectral-domain optical coherence tomography (SDOCT) modality is another imaging technique integrated into the system. It provides a cross-sectional imaging perspective that is comparable to microscopic images obtained from histology slides and complementary to the en face view obtained from the confocal imaging modality. The imaging system uses a parallelized architecture (fiber-optic bundle, line of illumination) to increase the data acquisition speed. A one-dimensional scan is needed to capture 2D images in the confocal modality or a 3D data cube (two spatial dimensions and one spectral dimension) in the multi-spectral mode of operation. No scanning is required to capture a 2D OCT image. The fiber-bundle design is particularly critical for the SDOCT modality as it paves the way to novel fast endoscopic OCT imaging that has a high potential for translation into the clinic. The integrated multi-modality imaging system can readily switch between different imaging modalities, which will make it a powerful diagnostic tool in a clinical environment. It can provide valuable information about the morphology, the spectral and biochemical features, and the macroscopic architecture of tissue. It is believed that fast and accurate disease diagnosis can potentially be made based on all these characteristics.
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Robles, Victor Adrian. "Automated image analysis of corneal structures in anterior-segment optical coherence tomography and in-vivo confocal microscopy images." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5988.

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Optical Coherence Tomography (OCT) is a noninvasive imaging modality that has significantly contributed to the quantitative assessment of ocular diseases. Another tool available to ophthalmic clinicians is in-vivo confocal microscopy, which allows anatomical structures to be observed live at the cellular level. Incorporating both of these modalities for imaging the cornea allows us to take structural measurements to characterize disease-related changes in corneal anatomy. Notable diseases that directly impact or correlate with corneal structures include glaucoma and diabetic neuropathy. Given glaucoma's impact as the second leading cause of blindness in the world, great efforts have been made in researching and understanding the disease. Correlations have been found between the central corneal thickness (CCT) and the risk of developing visual field loss in patients diagnosed with glaucoma. It should come as no surprise that measuring CCT among glaucoma suspects has also now become a clinical standard of practice. Diabetes is a group of metabolic diseases where the body experiences high blood sugar levels over prolonged periods of time. It is a prominent disease that affects millions of Americans each day. While not necessarily an ocular disease in its own right, it has been shown that diabetes can still affect the corneal structures. Diabetics have decreased corneal sensitivity and a significant link has been established between neuropathic severity in diabetic patients and corneal nerve fiber density. Given the availability of these imaging tools and the significant impact these prominent diseases have on society a growing focus has developed on relating corneal structure measurements and ophthalmic diseases. However, manually acquiring structural measures of the cornea can be a labor intensive and daunting task. Hence, experts have sought to develop automatic alternatives. The goals of our work includes the ability to automatically segment the corneal structures from anterior segment-optical coherence tomography (AS-OCT) and in-vivo confocal microscopy (IVCM) to provide useful structural information from the cornea. The major contributions of this work include 1) utilizing the information of AS-OCT imagery to segment the cornea layers simultaneously in 3D, 2) increasing the region-of-interest of IVCM imagery using a feature-based registration approach to develop a panorama from the images, 3) incorporating machine-learning techniques to segment the corneal nerves in the IVCM imagery, and 4) extracting structural measurements from the segmentation results to determine correlations between the structural measurements known to differ from the corneal structures in various subject groups.
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Perrot, Jean-Luc. "Explorations optiques multimodales et multiéchelles non invasives appliquées au revêtement cutanéomuqueux , étendues à l'appareil oculaire antérieur." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSES010/document.

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Après une introduction brève de l’historique de l’imagerie dermatologique non invasive, ce travail est divisé 3 parties. 1) Présentation d’un projet de développement d’un tomographe à cohérence optique miniaturisé, peu onéreu devant permettre une diffusion de cette technique aux dermatologues exerçant en dehors des hôpitaux. Il s’agi d’un projet ANR DOCT-VCSEL Portable Optical Coherence Tomography with MEMS-VCSEL swept- sources for skin analysis ANR 2015 / Défi sociétal « Vie, Santé et Bien-Etre » Axe 13 « Technologies pour la santé » 2) Présentation d’un projet dont le but est l’identification de lésions cutanées cancéreuses au moyen d’un nouvel OCT haute définition développé par la société DAMAE, issue de l’Institut supérieur d’Optique de Palaiseau. Il s’agit d’un dispositif qui sera dans un premier temps réservé aux centre d’excellence en imagerie dermatologique. 3) la reprise des 52 publications ayant trait à l’imagerie cutanée auxquelles j’ai participé et référencées dans les bases de données internationales au 31 décembre 2016. Ce travail couvre l’ensemble de l’imagerie non invasive dermatologique moderne et aborde des sujets qui n’avaient jamais été étudié de la sorte. Notamment les muqueuses et l’appareil oculaire antérieur mais aussi l’identification par microscopie confocale des marge chirurgicales ou l’association microscopie confocale spectrométrie Raman<br>After a brief introduction to the history of non-invasive dermatological imaging, this work is divided into 3 parts. 1) Presentation of a project for the development of a low-cost miniaturized optical coherence tomograph to allow dissemination of this technique to dermatologists practicing outside hospitals. This is an ANR project: DOCT-VCSEL Portable Optical Coherence Tomography with MEMS-VCSEL swept-sources for skin analysis ANR 2015 / Societal Challenge "Life, Health and Welfare" Axis 13 “Technologies for Health" 2) Presentation of a project whose goal is the identification of cancer skin lesions by means of a new high definition OCT developed by the company DAMAE, resulting from the Higher Institute of Optics of Palaiseau. It is a device that will initially be reserved for centers of excellence in dermatological imaging. 3) Presentation of 52 publications related to skin imaging, in which I participated, and referenced in the international databases as of December 31, 2016. This work covers all modern dermatological non-invasive imaging and addresses Subjects that had never been studied in this way. Notably the mucous membranes and the anterior ocular apparatus but also the identification by confocal microscopy of the surgical margins or the association confocal microscopy Raman spectrometry
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Costa, Christopher. "A study of the application of adaptive optics (AO) in optical coherence tomography (OCT) and confocal microscopy for the purpose of high resolution imaging." Thesis, University of Kent, 2016. https://kar.kent.ac.uk/56633/.

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A problem is presented when imaging the eye in that optical aberrations are introduced by tissues of the anterior eye such as the cornea and lens. Adaptive optics (AO) and scanning laser ophthalmoscopy (SLO) have been combined to detect and compensate for these aberrations through the use of one or more correcting devices. Di erent corrector options exist, such as a liquid crystal lens or a deformable mirror (DM), such as that used in this thesis. This study seeks to use the ability of the DM to add focus/defocus aberrations to the closed loop AO system. This procedure could allow for dynamic focus control during generation of B-scan images using spectral domain optical coherence tomography (SD-OCT), where typically this is only possible using slower time domain techniques. The confocal gate scanning is controlled using the focus altering aberrations created by changing the shape of the deformable mirror. Using the novel master-slave interferometry method, multiple live en-face images can be acquired simultaneously. In this thesis, application of this method to an AO system is presented whereby en-face images may be acquired at multiple depths simultaneously. As an extension to this research, an OCT despeckle method is demonstrated. Further to this work is the investigation of the role in AO for optimisation of optical systems without the requirement for direct aberration measurement. Towards this end, genetic algorithms (GA) may be employed to control the DM in an iterative process to improve the coupling of light into fibre.
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Boone, Marc. "High-definition optical coherence tomography: Contribution to the non-invasive near infrared optical imaging techniques of the skin." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/232235.

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Background. The development of non-invasive imaging techniques has been stimulated by the shortcomings of histopathology. Currently the only valid diagnostic technique in dermatology is skin biopsy which remains a painful, invasive intervention for the patient. Moreover, this approach is not always convenient for monitoring and follow-up of a skin disease. Optical imaging technologies could solve these shortcomings as they are fast, precise, repeatable and painless. There are four established non-invasive skin imaging techniques used in daily practice: dermoscopy, high-frequency ultrasound, reflectance confocal microscopy (RCM) and conventional optical coherence tomography (C-OCT). In imaging there is a trade-off between resolution and penetration depth. The former permits the visualization of cells, if the resolution is at least 3 µm. The latter enables the recognition of patterns and structures in deeper layers of the skin if the penetration depth is deeper than 150 µm. New non-invasive techniques using infrared light sources have been developed recently. The technique used in this work is a high-definition optical coherence tomography (HD-OCT).Objectives. The overall aims of this thesis were the feasibility of HD-OCT to visualize in/ex vivo, in real time and in 3-D the cellular and structural morphology of the skin, secondly the assessment of the capability of this technology to measure in vivo and real time the cutaneous optical properties, and finally the determination of the contribution of this technique to the non-invasive near-infrared imaging technologies. Five specific objectives have been established: i) could cells be observed in their 3-D microenvironment in normal and diseased skin, ii) could we describe morphologic features of cells and structures in normal and diseased skin (m_HD-OCT), iii) could these morphologic features be quantified by optical property analysis (o_HD-OCT), iv) was it possible to perform accurate thickness measurements in normal and diseased skin, and finally v) what was the diagnostic potential of this technique?Methodology. HD-OCT uses a combination of parallel time-domain interferometry, high power tungsten lamp (with Gaussian filter, very low lateral coherence and ultra-high bandwidth (1300 nm +/- 100 nm)), and last but not least, full field illumination with real time focus tracking. A constant homogeneous resolution of 3 µm resolution in all three dimensions is obtained up to a depth of 570 µm. Hence, the system is capable of capturing real time full 3-D images. Moreover, the in vivo assessment of optical properties of the skin is only applicable to OCT when operating in focus-tracking mode, which is the case for HD-OCT. The means to obtain answers to the five specific questions were the comparison of en face HD-OCT images with RCM and HD-OCT cross-sectional images with histopathology and C-OCT. Results. At least 160 line pares were observed by imaging a high resolution phantom with HD-OCT. This suggested a 3 µm lateral resolution. The presence of cells such as keratinocytes, melanocytes, inflammatory cells, fibroblasts and melanophages in their 3-D cutaneous microenvironment in vivo as well as ex vivo has been demonstrated .A qualitative description of structures and patterns in normal and diseased skin could be performed by HD-OCT. Clear structural changes of the epidermis, dermo-epidermal junction, papillary dermis and reticular dermis related to intrinsic skin ageing could be observed. Lobulated structures, surrounded by stretched stromal fibers and arborizing vessels, could be demonstrated in nodular basal cell carcinoma (BCC). The o_HD-OCT of normal and diseased skin could be assessed in vivo. This approach permitted the quantitative assessment of the OCT signal attenuation profiles of normal healthy skin, actinic keratosis (AK) and squamous cell carcinoma (SCC). Differences in signal attenuation profiles could be demonstrated between these three groups. These differences were also observed between BCC subtypes. The slope of the exponential attenuation of the signal in the upper part of the epidermis was very high in benign nevi. The more malignant the lesion the lower the slope. Thickness measurements of epidermis and papillary dermis could be performed by m_HD-OCT, based on a cross-sectional images and their corresponding en face image. More accurate measurements of epidermal and papillary dermal thickness could be performed based on the optical analysis of a skin volume by o_HD-OCT. The diagnostic potential of HD-OCT in comparison with dermoscopy, RCM and C-OCT could be assessed regarding i) melanoma, ii) BCC differentiation from BCC imitators and BCC sub-differentiation and iii) SCC differentiation from AK. A much higher diagnostic potential could be demonstrated for o_HD-OCT in comparison with m_HD-OCT concerning melanoma detection. The diagnostic potential of HD-OCT to discriminate BCC from clinical BCC imitators was moderate. However, HD-OCT seemed to have high potential in sub-differentiation of BCC subtypes: i) it seemed to be the best technique to include and exclude a superficial BCC, ii) the technique appeared to be the best approach to exclude nodular BCC, and iii) HD-OCT looked to be the best technique to include an infiltrative BCC. Finally, HD-OCT has proven to be a powerful method to discriminate AK from SCC.Conclusions. HD-OCT is able to capture real time 3-D imaging with a sufficiently high optical resolution and penetration depth to allow the visualization of cells in and ex vivo in their micro-architectural context. At the same time, HD-OCT permits the recognition of patterns and structures in a sufficiently large volume of skin (1.5 mm³). HD-OCT closes therefore the gap between RCM with a high resolution but low penetration depth and C-OCT with a low resolution but high penetration depth. Moreover, HD-OCT permits, in contrast to RCM and C-OCT, the real time in vivo analysis of optical properties of the skin. HD-OCT seems to be a promising tool for early diagnosis of melanoma, BCC sub-differentiation and differentiation between SCC and AK.Future perspectives. Multicenter validation studies are needed to determine the diagnostic performance of this promising new technology, especially in other clinical settings combining both morphological and optical property analysis. This combined analysis could be a valuable method not only for diagnosis, monitoring and therapeutic guidance of dermatologic diseases but it could also be helpful in the management of non-dermatologic conditions such as diabetic micro-angiopathy, infantile cystinosis or even osteoporosis.<br>Doctorat en Sciences médicales (Santé Publique)<br>info:eu-repo/semantics/nonPublished
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Bibikova, O. (Olga). "Plasmon-resonant gold nanoparticles for bioimaging and sensing applications." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526219974.

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Abstract This thesis reports on studies of plasmonic nanoparticles and particularly gold nanostars as signal enhancers and contrast agents for biophotonic applications including visualisation, treatment of living cells and chemical sensing. In this thesis, the optical properties of nanoparticles of different size and morphology and their silica composites were compared. Because they are the most suitable plasmonic nanostructures, gold nanostars were utilised for optical imaging modalities such as confocal microscopy and Doppler optical coherence tomography. The ability of gold nanoparticles to enhance the signal in surface-enhanced vibrational spectroscopy, including Raman and Fourier transform infrared spectroscopy was additionally studied. Finally, various gold nanoparticles were applied for cell optoporation to increase the penetration ability of exogeneous substances. In summary, significant advantages of nanostars such as their low-toxicity, high scattering and contrast abilities, in addition to a broad, tunable, plasmon resonance wavelength range, as well as the capability to enhance the signal of analyte molecules in vibrational spectroscopy were demonstrated in this thesis. The results of this study on the effectiveness of nanostars have a broad scope of utility and open a wide perspective for their utilisation in nanobiophotonics and biomedicine<br>Tiivistelmä Tämä opinnäytetyö kertoo tutkimuksista, joissa plasmoninanopartikkeleita ja erityisesti kultananotähtiä on käytetty signaalinvahvistimina biofotoniikan sovelluksissa, kuten visualisointi, elävien solujen käsittely ja kemiallinen tunnistus. Tässä työssä verrattiin eri kokoisten ja muotoisten nanopartikkeleiden ja niiden piioksidikomposiittien optisia ominaisuuksia. Sopivimpina plasmoninanorakenteina kultananotähtiä käytettiin optisiin kuvantamismenetelmiin, kuten konfokaalimikroskopiaan ja Doppler-optiseen koherenssitomografiaan. Lisäksi kuvattiin myös kultananopartikkelien kykyä parantaa pinta-aktivoidun värähtelevän spektroskopian signaalia, mukaan lukien Raman- ja Fourier-muunnos-infrapuna-spektroskopia. Lopuksi, eri kultananopartikkeleita käytettiin soluoptoporaatioon eksogeenisten aineiden läpäisevyyden lisäämiseksi. Yhteenvetona, työssä osoitettiin nanotähtien merkittävät edut, kuten matala-myrkyllisyys, suuret sironta- ja kontrastiominaisuudet, laaja plasmoniresonanssin aallonpituusalue ja sen viritettävyys, sekä kyky parantaa analyyttimolekyylien signaalia värähtelyspektroskopiassa. Niinpä tutkimustulokset nanotähtien tehokkuudesta ovat laajasti käyttökelpoisia ja ne avaavat laajan näkökulman niiden hyödyntämiseen nanobiofotoniikassa ja biolääketieteessä
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Velthoven, Mirjam Emma Johanna van. "Combined en-face optical coherence tomography and confocal ophthalmoscopy for retinal imaging." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/34981.

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Lee, Kye-Sung. "EXTENDED FOCUS RANGE HIGH RESOLUTION ENDOSCOPIC OPTICAL COHERENCE TOMOGRAPHY." Doctoral diss., University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3085.

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Today, medical imaging is playing an important role in medicine as it provides the techniques and processes used to create images of the human body or parts thereof for clinical purposes (medical procedures seeking to reveal, diagnose or examine disease) or medical science (including the study of normal anatomy and function). Modalities are developing over time to achieve the highest possible resolution, speed of image acquisition, sensitivity, and specificity. In the past decade, advances in optics, fiber, as well as laser technology have enabled the development of noninvasive optical biomedical imaging technology that can also be applied to endoscopy to reach deeper locations in the human body. The purpose of this dissertation is to investigate a full system design and optimization of an optical coherence tomography (OCT) system to achieve high axial and lateral resolution together with an extended depth of focus for endoscopic in vivo imaging. In this research aimed at advancing endoscopic OCT imaging, two high axial resolution optical coherence tomography systems were developed: (1) a spectrometer-based frequency-domain (FD) OCT achieving an axial resolution of ~2.5 µm using a Ti:Sa femtosecond laser with a 120nm bandwidth centered at 800nm and (2) a swept-source based FD OCT employing a high speed Fourier domain mode locked (FDML) laser that achieves real time in vivo imaging with ~8 µm axial resolution at an acquisition speed of 90,000 A-scans/sec. A critical prior limitation of FD OCT systems is the presence of mirror images in the image reconstruction algorithm that could only be eliminated at the expense of depth and speed of imaging. A key contribution of this research is the development of a novel FD OCT imager that enables full range depth imaging without a loss in acquisition speed. Furthermore, towards the need for better axial resolution, we developed a mathematical model of the OCT signal that includes the effect on phase modulation of phase delay, group delay, and dispersion. From the mathematical model we saw that a Fourier domain optical delay line (FD ODL) incorporated into the reference arm of the OCT system represented a path to higher performance. Here we then present a method to compensate for overall system dispersion with a FDODL that maintains the axial resolution at the limit determined solely by the coherence length of a broadband source. In the development of OCT for endoscopic applications, the need for long depth of focus imaging is critical to accommodate the placement of the catheter anywhere within a vessel. A potential solution to this challenge is Bessel-beam imaging. In a first step, a Bessel-beam based confocal scanning optical microscopy (BCSOM) using an axicon and single mode fiber was investigated with a mathematical model and simulation. The BCSOM approach was then implemented in a FD OCT system that delivered high lateral resolution over a long depth of focus. We reported on the imaging in biological samples for the first time with a double-pass microoptics axicon that demonstrated clearly invariant SNR and 8 um lateral resolution images across a 4 mm depth of focus. Finally, we describe the design and fabrication of a catheter incorporated in the FD OCT. The design, conceived for a 5 mm outer diameter catheter, allows 360 degree scanning with a lateral resolution of about 5 um across a depth of focus of about 1.6 mm. The dissertation concludes with comments for related future work.<br>Ph.D.<br>Optics and Photonics<br>Optics and Photonics<br>Optics PhD
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Xue, Wei Kai. "Multimodal Line-Field Confocal Optical Coherence Tomography (LC-OCT) for skin cancer diagnostics." Thesis, KTH, Tillämpad fysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-239616.

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Books on the topic "Optical coherence tomography and confocal microscopy"

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International Conference on Optical Instruments and Technology (2009 Shanghai, China). 2009 International Conference on Optical Instruments and Technology: Optical trapping and microscopic imaging : 19-22 October 2009, Shanghai, China. Edited by Yuan Xiaocong, Zhongguo yi qi yi biao xue hui, Zhongguo guang xue xue hui, SPIE (Society), and Zhongguo yi qi yi biao xue hui. Optoelectronic-Mechanic Technology and System Integration Chapter. SPIE, 2009.

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Xiaocong, Yuan, Zhongguo yi qi yi biao xue hui, Zhongguo guang xue xue hui, SPIE (Society), and Zhongguo yi qi yi biao xue hui. Optoelectronic-Mechanic Technology and System Integration Chapter, eds. 2009 International Conference on Optical Instruments and Technology: Optical trapping and microscopic imaging : 19-22 October 2009, Shanghai, China. SPIE, 2009.

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Tuchin, V. V. Handbook of Coherent-Domain Optical Methods: Biomedical Diagnostics, Environmental Monitoring, and Materials Science. 2nd ed. Springer New York, 2013.

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Stefan, Andersson-Engels, Kaschke Michael F, Optical Society of America, Society of Photo-optical Instrumentation Engineers., and Deutsche Gesellschaft für Lasermedizin, eds. Photon migration, optical coherence tomography, and microscopy: 18-21 June 2001, Munich, Germany. SPIE, 2001.

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Optical Interferometry For Biology And Medicine. Springer, 2011.

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Book chapters on the topic "Optical coherence tomography and confocal microscopy"

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Neerken, Sieglinde, Gerald W. Lucassen, Tom A. M. Nuijs, Egbert Lenderink, and Rob F. M. Hendriks. "Comparison of Confocal Laser Scanning Microscopy and Optical Coherence Tomography." In Handbook of Coherent Domain Optical Methods. Springer US, 2004. http://dx.doi.org/10.1007/0-387-29989-0_22.

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van Haasterecht, L., Paul P. M. van Zuijlen, and ML Groot. "Structural Assessment of Scars Using Optical Techniques." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_19.

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Abstract:
AbstractThe evaluation of scar treatment benefits from exact structural measurements. Accurate assessment of thickness, surface area, and relief is crucial in routine clinical follow-up. From an experimental perspective, precise visualization of the microstructural organization is necessary for a better understanding of the mechanisms underlying pathological scarring. Structural proteins in scars differ from healthy skin in terms of amount, type, and importantly, organization. The precise quantification of this extracellular matrix (ECM) organization was, until recently, limited to two-dimensional images from fixated and stained tissue. Advances in optical techniques now allow high-resolution imaging of these structures, in some cases in vivo. The enormous potential of these techniques as objective assessment tools is illustrated by a substantial increase in available devices. This chapter describes currently used devices and techniques used in the clinical follow-up of scar progression from a volumetric standpoint. Furthermore, some of the most powerful techniques for microstructural research are described including optical coherence tomography, nonlinear optical techniques such as second harmonic generation microscopy, and confocal microscopy.
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Aguirre, Aaron D., Chao Zhou, Hsiang-Chieh Lee, Osman O. Ahsen, and James G. Fujimoto. "Optical Coherence Microscopy." In Optical Coherence Tomography. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-06419-2_29.

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Aguirre, A. D., and J. G. Fujimoto. "Optical Coherence Microscopy." In Optical Coherence Tomography. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-77550-8_17.

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Adie, Steven G., Nathan D. Shemonski, Tyler S. Ralston, P. Scott Carney, and Stephen A. Boppart. "Interferometric Synthetic Aperture Microscopy (ISAM)." In Optical Coherence Tomography. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-06419-2_32.

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Harms, Fabrice, Anne Latrive, and A. Claude Boccara. "Time Domain Full Field Optical Coherence Tomography Microscopy." In Optical Coherence Tomography. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-06419-2_26.

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de Smet, Marc D., and Mirjam E. J. van Velthoven. "Combined Optical Coherence Tomography and Confocal Ophthalmoscopy (OCT/SLO)." In Optical Coherence Tomography in Age-Related Macular Degeneration. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01467-3_5.

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Sheppard, C. J. R., and M. Roy. "Image Formation in Optical Coherence Tomography and Microscopy." In Optics and Lasers in Biomedicine and Culture. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-56965-4_54.

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Aumann, Silke, Sabine Donner, Jörg Fischer, and Frank Müller. "Optical Coherence Tomography (OCT): Principle and Technical Realization." In High Resolution Imaging in Microscopy and Ophthalmology. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-16638-0_3.

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Moreau, Julien. "Chapter 14 Spectroscopic Full-Field Optical Coherence Tomography." In Handbook of Full-Field Optical Coherence Microscopy. Pan Stanford Publishing Pte. Ltd., 2016. http://dx.doi.org/10.1201/9781315364889-15.

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Conference papers on the topic "Optical coherence tomography and confocal microscopy"

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Negrutiu, Meda L., Cosmin Sinescu, Michael Hughes, et al. "Optical coherence tomography and confocal microscopy investigations of dental prostheses." In 1st Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics. SPIE, 2008. http://dx.doi.org/10.1117/12.816672.

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Ogien, Jonas, Olivier Levecq, Hicham Azimani, David Siret, Jean-Luc Perrot, and Arnaud Dubois. "Line-field confocal optical coherence tomography: technology and application in dermatology." In Biomedical Spectroscopy, Microscopy, and Imaging, edited by Jürgen Popp and Csilla Gergely. SPIE, 2020. http://dx.doi.org/10.1117/12.2554400.

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Tuohy, Simon, Adrian Bradu, Fabrice Harms, Nicolas Chateau, and Adrian G. Podoleanu. "Adaptive optics loop for en-face optical coherence tomography and laser scanning confocal microscopy." In 1st Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics. SPIE, 2008. http://dx.doi.org/10.1117/12.817814.

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Bradu, A., Lisha Ma, J. Bloor, and A. Podoleanu. "Combining confocal microscopy and optical coherence tomography for imaging in developmental biology." In Photonics Europe, edited by Jürgen Popp, Wolfgang Drexler, Valery V. Tuchin, and Dennis L. Matthews. SPIE, 2008. http://dx.doi.org/10.1117/12.781041.

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Romînu, Roxana Otilia, Cosmin Sinescu, Mihai Romînu, et al. "An innovative approach for investigating the ceramic bracket-enamel interface - optical coherence tomography and confocal microscopy." In 1st Canterbury Workshop and School in Optical Coherence Tomography and Adaptive Optics. SPIE, 2008. http://dx.doi.org/10.1117/12.814894.

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Negrutiu, Meda L., Cosmin Sinescu, Mihai Rominu, Michael Hughes, George Dobre, and Adrian G. Podoleanu. "Optical coherence tomography and confocal microscopy investigations of dental structures and restoration materials." In SPIE Medical Imaging, edited by Ehsan Samei and Jiang Hsieh. SPIE, 2009. http://dx.doi.org/10.1117/12.813867.

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Jacques, S., R. Samatham, N. Choudhury, and D. S. Gareau. "Specifying tissue optical properties using axial dependence of confocal reflectance images: confocal scanning laser microscopy and optical coherence tomography." In Biomedical Optics (BiOS) 2007, edited by Adam Wax and Vadim Backman. SPIE, 2007. http://dx.doi.org/10.1117/12.716535.

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Rominu, Mihai, Cosmin Sinescu, Emanuela Petrescu, et al. "Optical Coherence Tomography Combined with Confocal Microscopy for Investigation of Interfaces in Class V Cavities." In European Conference on Biomedical Optics. OSA, 2009. http://dx.doi.org/10.1364/ecbo.2009.7372_28.

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Rominu, Mihai, Cosmin Sinescu, Emanuela Petrescu, et al. "Optical coherence tomography combined with confocal microscopy for investigation of interfaces in class V cavities." In European Conferences on Biomedical Optics, edited by Peter E. Andersen and Brett E. Bouma. SPIE, 2009. http://dx.doi.org/10.1117/12.831803.

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Rinehart, Matthew T., Jeffrey LaCroix, Marcus Henderson, David Katz, and Adam Wax. "Simultaneous confocal fluorescence microscopy and optical coherence tomography for drug distribution and tissue integrity assessment." In SPIE BiOS, edited by Anita Mahadevan-Jansen, Tuan Vo-Dinh, and Warren S. Grundfest. SPIE, 2011. http://dx.doi.org/10.1117/12.874986.

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