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Dissertations / Theses on the topic 'Optical coherence tomography and confocal microscopy'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Risi, Matthew D. "Advances In Combined Endoscopic Fluorescence Confocal Microscopy And Optical Coherence Tomography." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/332772.

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Confocal microendoscopy provides real-time high resolution cellular level images via a minimally invasive procedure. Results from an ongoing clinical study to detect ovarian cancer with a novel confocal fluorescent microendoscope are presented. As an imaging modality, confocal fluorescence microendoscopy typically requires exogenous fluorophores, has a relatively limited penetration depth (100μm), and often employs specialized aperture configurations to achieve real-time imaging in vivo. Two primary research directions designed to overcome these limitations and improve diagnostic capability a

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2

Makhlouf, Houssine. "Integrated Multi-Spectral Fluorescence Confocal Microendoscope and Spectral-Domain Optical Coherence Tomography Imaging System for Tissue Screening." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/202761.

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A multi-modality imaging system intended for clinical utilization has been developed. It is constructed around an existing fiber-bundle-based fluorescence confocal microendoscope. Additional imaging modalities have been implemented to expand the capabilities of the system and improve the accuracy of disease diagnosis. A multi-spectral mode of operation is one such modality. It acquires fluorescence images of a biological sample across a spectral range of sensitivity and explores the collected image data at any specified wavelength within that spectral range. Cellular structures can be differen

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Robles, Victor Adrian. "Automated image analysis of corneal structures in anterior-segment optical coherence tomography and in-vivo confocal microscopy images." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5988.

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Optical Coherence Tomography (OCT) is a noninvasive imaging modality that has significantly contributed to the quantitative assessment of ocular diseases. Another tool available to ophthalmic clinicians is in-vivo confocal microscopy, which allows anatomical structures to be observed live at the cellular level. Incorporating both of these modalities for imaging the cornea allows us to take structural measurements to characterize disease-related changes in corneal anatomy. Notable diseases that directly impact or correlate with corneal structures include glaucoma and diabetic neuropathy. Given

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4

Perrot, Jean-Luc. "Explorations optiques multimodales et multiéchelles non invasives appliquées au revêtement cutanéomuqueux , étendues à l'appareil oculaire antérieur." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSES010/document.

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Après une introduction brève de l’historique de l’imagerie dermatologique non invasive, ce travail est divisé 3 parties. 1) Présentation d’un projet de développement d’un tomographe à cohérence optique miniaturisé, peu onéreu devant permettre une diffusion de cette technique aux dermatologues exerçant en dehors des hôpitaux. Il s’agi d’un projet ANR DOCT-VCSEL Portable Optical Coherence Tomography with MEMS-VCSEL swept- sources for skin analysis ANR 2015 / Défi sociétal « Vie, Santé et Bien-Etre » Axe 13 « Technologies pour la santé » 2) Présentation d’un projet dont le but est l’identificatio

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Costa, Christopher. "A study of the application of adaptive optics (AO) in optical coherence tomography (OCT) and confocal microscopy for the purpose of high resolution imaging." Thesis, University of Kent, 2016. https://kar.kent.ac.uk/56633/.

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A problem is presented when imaging the eye in that optical aberrations are introduced by tissues of the anterior eye such as the cornea and lens. Adaptive optics (AO) and scanning laser ophthalmoscopy (SLO) have been combined to detect and compensate for these aberrations through the use of one or more correcting devices. Di erent corrector options exist, such as a liquid crystal lens or a deformable mirror (DM), such as that used in this thesis. This study seeks to use the ability of the DM to add focus/defocus aberrations to the closed loop AO system. This procedure could allow for dynamic

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6

Boone, Marc. "High-definition optical coherence tomography: Contribution to the non-invasive near infrared optical imaging techniques of the skin." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/232235.

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Background. The development of non-invasive imaging techniques has been stimulated by the shortcomings of histopathology. Currently the only valid diagnostic technique in dermatology is skin biopsy which remains a painful, invasive intervention for the patient. Moreover, this approach is not always convenient for monitoring and follow-up of a skin disease. Optical imaging technologies could solve these shortcomings as they are fast, precise, repeatable and painless. There are four established non-invasive skin imaging techniques used in daily practice: dermoscopy, high-frequency ultrasound, re

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Bibikova, O. (Olga). "Plasmon-resonant gold nanoparticles for bioimaging and sensing applications." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526219974.

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Abstract This thesis reports on studies of plasmonic nanoparticles and particularly gold nanostars as signal enhancers and contrast agents for biophotonic applications including visualisation, treatment of living cells and chemical sensing. In this thesis, the optical properties of nanoparticles of different size and morphology and their silica composites were compared. Because they are the most suitable plasmonic nanostructures, gold nanostars were utilised for optical imaging modalities such as confocal microscopy and Doppler optical coherence tomography. The ability of gold nanoparticles to

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Velthoven, Mirjam Emma Johanna van. "Combined en-face optical coherence tomography and confocal ophthalmoscopy for retinal imaging." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/34981.

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Lee, Kye-Sung. "EXTENDED FOCUS RANGE HIGH RESOLUTION ENDOSCOPIC OPTICAL COHERENCE TOMOGRAPHY." Doctoral diss., University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3085.

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Today, medical imaging is playing an important role in medicine as it provides the techniques and processes used to create images of the human body or parts thereof for clinical purposes (medical procedures seeking to reveal, diagnose or examine disease) or medical science (including the study of normal anatomy and function). Modalities are developing over time to achieve the highest possible resolution, speed of image acquisition, sensitivity, and specificity. In the past decade, advances in optics, fiber, as well as laser technology have enabled the development of noninvasive optical biomedi

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Xue, Wei Kai. "Multimodal Line-Field Confocal Optical Coherence Tomography (LC-OCT) for skin cancer diagnostics." Thesis, KTH, Tillämpad fysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-239616.

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11

Zhou, Yifeng. "Design and application of combined multiphoton microscopy and optical coherence tomography system." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43195.

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Optical coherence tomography (OCT) is a non-invasive optical tomographic technique based on the principle of interferometry. It can capture micrometer-resolution, three-dimensional images of tissues over millimeter field-of-view at a fast speed. Multiphoton microscopy (MPM) is an emerging imaging modality based on the excitation of nonlinear signals from fluorescent molecules and the induction of second harmonic generation (SHG). It is capable of en-face high-resolution imaging with sub-micron resolution. Although OCT and MPM are essential imaging tools for disease diagnosis, each one of them

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Liu, Xiaojing. "Optical Coherence Photoacoustic Microscopy (OC-PAM) for Multimodal Imaging." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/3189.

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Optical coherence tomography (OCT) and Photoacoustic microscopy (PAM) are two noninvasive, high-resolution, three-dimensional, biomedical imaging modalities based on different contrast mechanisms. OCT detects the light backscattered from a biological sample either in the time or spectral domain using an interferometer to form an image. PAM is sensitive to optical absorption by detecting the light-induced acoustic waves to form an image. Due to their complementary contrast mechanisms, OCT and PAM are suitable for being combined to achieve multimodal imaging. In this dissertation, an optical coh

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Nam, Ahhyun. "Development and translation of label-free functional microscopy based on optical coherence tomography." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/108851.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2017.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Optical coherence tomography (OCT), an imaging modality based on low coherence interferometry, can be extended to obtain various endogenous functional contrasts. This thesis focuses on the development and translation of angiographic and polarization

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Aguirre, Aaron Dominic 1977. "Advances in Optical Coherence Tomography and Microscopy for endoscopic applications and functional neuroimaging." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43740.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2008.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references.<br>Optical Coherence Tomography (OCT) is a developing medical imaging technology that generates micron resolution cross-sectional images of subsurface internal tissue structure in situ and in real time, without the need to remove and process specimens. Previous studies have suggested that OCT holds great potential for use in lapa

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15

Xu, Wei. "Analog Signal Processing for Optical Coherence Imaging Systems." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195225.

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Optical coherence tomography (OCT) and optical coherence microscopy (OCM) are non-invasive optical coherence imaging techniques, which enable micron-scale resolution, depth resolved imaging capability. Both OCT and OCM are based on Michelson interferometer theory. They are widely used in ophthalmology, gastroenterology and dermatology, because of their high resolution, safety and low cost. OCT creates cross sectional images whereas OCM obtains en face images. In this dissertation, the design and development of three increasingly complicated analog signal processing (ASP) solutions for optical

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Korde, Vrushali Raj. "OPTICAL IMAGING MODALITIES: FROM DESIGN TO DIAGNOSIS OF SKIN CANCER." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/193716.

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This study investigates three high resolution optical imaging modalities to better detect and diagnose skin cancer. The ideal high resolution optical imaging system can visualize pre-malignant tissue growth non-invasively with resolution comparable to histology. I examined 3 modalities which approached this goal. The first method examined was high magnification microscopy of thin stained tissue sections, together with a statistical analysis of nuclear chromatin patterns termed Karyometry. This method has subcellular resolution, but it necessitates taking a biopsy at the desired tissue site

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Cimalla, Peter, Theresa Werner, Kai Winkler, et al. "Imaging of nanoparticle-labeled stem cells using magnetomotive optical coherence tomography, laser speckle reflectometry, and light microscopy." SPIE, 2015. https://tud.qucosa.de/id/qucosa%3A35268.

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Cell transplantation and stem cell therapy are promising approaches for regenerative medicine and are of interest to researchers and clinicians worldwide. However, currently, no imaging technique that allows three-dimensional in vivo inspection of therapeutically administered cells in host tissues is available. Therefore, we investigate magnetomotive optical coherence tomography (MM-OCT) of cells labeled with magnetic particles as a potential noninvasive cell tracking method. We develop magnetomotive imaging of mesenchymal stem cells for future cell therapy monitoring. Cells were labeled with

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Watson, Jennifer Marie. "Examination of Diagnostic Features in Multiphoton Microscopy and Optical Coherence Tomography Images of Ovarian Tumorigenesis in a Mouse Model." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293473.

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Ovarian cancer is a deadly disease owing to the non-specific symptoms and suspected rapid progression, leading to frequent late stage detection and poor prognosis. Medical imaging methods such as CT, MRI and ultrasound as well as serum testing for cancer markers have had extremely poor performance for early disease detection. Due to the poor performance of available screening methods, and the impracticality and ineffectiveness of taking tissue biopsies from the ovary, women at high risk for developing ovarian cancer are often advised to undergo prophylactic salpingo-oophorectomy. This surgery

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Kong, Jun. "A Study of Computer Vision and Pattern Recognition in Medical Image Analysis: Digital Microscopy and Optical Coherent Tomography." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1228075056.

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SANTOS, MOISES O. dos. "Ablação de pele queimada com laser de pulsos ultra-curtos para promoção da cicatrização. Avaliação por tomografia por coerência óptica, histologia, µATR-FTIR e microscopia não-linear." reponame:Repositório Institucional do IPEN, 2012. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10171.

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Made available in DSpace on 2014-10-09T12:35:35Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:04:00Z (GMT). No. of bitstreams: 0<br>Tese (Doutoramento)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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Hillman, Timothy R. "Microstructural information beyond the resolution limit : studies in two coherent, wide-field biomedical imaging systems." University of Western Australia. School of Electrical, Electronic and Computer Engineering, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0085.

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Ma, Pei. "OPTICAL IMAGING OF EMBRYONIC CARDIAC CONDUCTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1464714110.

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23

Federici, Antoine. "Développement de systèmes de microscopie par cohérence optique plein champ étendus spatialement et spectralement." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS024/document.

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La tomographie par cohérence optique plein champ (OCT plein champ) est une technique de microscopie interférométrique basée sur l’utilisation d’une source de lumière faiblement cohérente, telle qu’une lampe halogène. Elle permet de réaliser, de façon non invasive, des images tomographiques à plusieurs centaines de micromètres de profondeur dans les tissus biologiques et avec une résolution spatiale isotrope de l’ordre de 1 µm. Ces travaux de thèse concernent le développement de plusieurs systèmes d'OCT plein champ, dans le but de proposer de nouvelles performances et de nouveaux contrastes des

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Quitero, Mayra Fidelis Zamboni. "Obtenção in vitro de mancha branca por desafio cariogênico misto." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/23/23134/tde-03112016-195812/.

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A proposta deste estudo in vitro foi otimizar o método microbiológico para a produção de lesão de mancha branca em esmalte que possa ser validada por ensaio não destrutivo (tomografia por coerência óptica - OCT) para possibilitar a utilização posterior dos espécimes em outros experimentos. Foram obtidos 168 fragmentos retangulares de esmalte bovino com janelas centrais de desmineralização de 3,0 x 3,0 mm. Os grupos experimentais foram compostos a partir de 3 fatores de variação: microrganismo (S. mutans UA 159, S. sobrinus 3347 e S. mutans + S. sobrinus), fonte de carboidrato (sacarose 1% e sa

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Ogien, Jonas. "Développement de systèmes de microscopie par cohérence optique pour l'imagerie de la peau." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLO011/document.

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La microscopie par cohérence optique (OCM) est une technique d'imagerie tomographique basée sur l'interférométrie en lumière blanche permettant d'imager les milieux biologiques à l'échelle microscopique. L'OCM est une méthode particulièrement adaptée à l'imagerie dermatologique, en particulier pour le diagnostic du cancer de la peau, car elle permet d'obtenir des images similaires aux images histologiques sans nécessiter d'effectuer de biopsie.Ces travaux de thèse portent sur le développement de la microscopie par cohérence optique pour l'imagerie de la peau, dans le but de fournir au dermatol

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Gaertner, Maria, Kerstin Schirrmann, Christian Schnabel, et al. "Toward a comprehensive interpretation of intravital microscopy images in studies of lung tissue dynamics." SPIE, 2015. https://tud.qucosa.de/id/qucosa%3A35305.

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Intravital microscopy (IVM) is a well-established imaging technique for real-time monitoring of microscale lung tissue dynamics. Although accepted as a gold standard in respiratory research, its characteristic image features are scarcely understood, especially when trying to determine the actual position of alveolar walls. To allow correct interpretation of these images with respect to the true geometry of the lung parenchyma, we analyzed IVM data of alveoli in a mouse model in comparison with simultaneously acquired optical coherence tomography images. Several IVM characteristics, such as dou

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Scholler, Jules. "Imagerie optique 3D multimodale : traitements spatio-temporels, correction du front d'onde et classification automatique." Thesis, Université Paris sciences et lettres, 2020. http://www.theses.fr/2020UPSLS007.

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Cette thèse vise à appliquer et combiner des méthodes numériques et optiques pour repousser les limites de la tomographie optique cohérente plein champ (FFOCT) statique et dynamique pour la microscopie et l'imagerie médicale. Des méthodes de post-traitement utilisant la décomposition en valeurs singulières ont permis pour la première fois l'acquisition d'images dynamiques in vivo tandis que l'utilisation des signaux non stationnaires a permis d'obtenir des images avec un meilleur rapport signal sur bruit, soit la possibilité d'imager plus profondément les échantillons. L'application de l'image

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Thouvenin, Olivier. "Optical 3D imaging of subcellular dynamics in biological cultures and tissues : applications to ophthalmology and neuroscience." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC169/document.

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Cette thèse a pour objectif l’étude d’un lien effectif potentiel entre la motilité cellulaire, la mécanique cellulaire, et l’activité biochimique de ces mêmes cellules. Ce couplage a été étudié dans divers systèmes biologiques, et aussi bien dans des cultures de cellules qu’à l’intérieur de tissus plus complexes. Notamment, nous avons particulièrement cherché à détecter un couplage électromécanique dans des neurones qui pourrait être impliqué dans la propagation du message nerveux.Pour ce faire, nous avons dû développer deux microscopes optiques à la sensibilité extrême. Ces microscopes se com

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Meiniel, William. "Développement et mise en oeuvre de stratégies d'échantillonnage comprimé pour le débruitage et l'acquisition d'images en microscopie à fluorescence et en tomographie en cohérence optique." Electronic Thesis or Diss., Paris, ENST, 2018. http://www.theses.fr/2018ENST0052.

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Dans le cadre de la théorie mathématique de l’échantillonnage comprimé (Compressed Sensing, CS), développée récemment, il est possible de reconstruire un signal ou une image à partir de très peu d’acquisitions. Dans cette thèse, nous étudions comment cette théorie peut être adaptée à deux techniques de microscopie optique : la microscopie à fluorescence, et la tomographie en cohérence optique. Ces deux technologies présentent chacune des limitations, qui peuvent être corrigées par prise en compte de stratégies d’échantillonnage comprimé, que l’on peut diviser en deux catégories : des solutions

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Leong-Hoï, Audrey. "Etude des techniques de super-résolution latérale en nanoscopie et développement d'un système interférométrique nano-3D." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAD048/document.

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Ce manuscrit de thèse présente l’étude des techniques de super-résolution latérale en nanoscopie optique, qui est une des nouvelles techniques d'imagerie haute résolution, aujourd'hui largement utilisée en biophysique et en imagerie médicale, pour imager et caractériser des nanostructures, tout en conservant les avantages de l'imagerie optique en champ lointain comme un vaste champ, la visualisation et l’analyse en temps réel…Un des défis futurs de la microscopie 3D super-résolue est d’éviter l’utilisation des marqueurs fluorescents. La microscopie interférométrique fait partie des techniques

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Cheng, Nai-Chia, and 鄭乃嘉. "Study of Integrating Optical Coherence Tomography and Confocal Fluorescence Microscopy." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/02063773693470282307.

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碩士<br>臺灣大學<br>光電工程學研究所<br>98<br>Optical coherence tomography (OCT) and confocal fluorescence miroscopy (CFM) are the two most important noninvasive optical diagnosis techniques nowadays. OCT provides structural information in tissue by detecting variation of scattering property of living sample, where CFM measures the intensity of fluorescence signals point-to-point in three-dimensional (3D) space, and achieves high resolution functional imaging. The two techniques provide not only spatial resolution with micrometer scale but also complementary image information. Therefore, it is an very impor

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Ghasemi, Nasrin. "Central and Peripheral Cornea and Corneal Epithelium Characterized Using Optical Coherence Tomography and Confocal Microscopy." Thesis, 2008. http://hdl.handle.net/10012/3727.

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Abstract Both in the closed and open eye state the superior limbus is covered by the upper lid. This region is of physiological interest and clinical importance because in chronic hypoxia, neovascularization of the cornea commonly occurs here. The limbal region in general is additionally of importance as the stem cells which are the source of the new corneal cells are located in the epithelium of the limbus and these are vital for normal functioning and are affected under certain adverse conditions. Purpose: In this experiment I examined corneal morphology in the limbal area and in particular

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"Assessment of glaucoma progression using digital imaging technologies." 2015. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1291534.

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Glaucoma is characterized by progressive optic nerve head (ONH) deformation and retinal nerve fiber layer (RNFL) thinning but the relative sequence of ONH and RNFL changes in glaucoma remains largely uncertain. It has been proposed that structural damage of the optic nerve can often be detected before detectable functional loss. Therefore, investigating structural changes of the ONH and RNFL is of importance and relevance in the monitoring and management of glaucoma progression. Spectral domain optical coherence tomography (OCT), scanning laser polarimetry (SLP) and confocal scanning laser oph

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Baltazar, Luís Filipe Almeida. "Comparing different methods to measure biofilm thickness: the techniques are: optical coherence tomography, confocal laser scanning microscopy and low load compression test." Master's thesis, 2015. http://hdl.handle.net/1822/39586.

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Dissertação de mestrado integrado em Engenharia Biomédica (área de especialização em Engenharia Clínica)<br>Biofilm formation remains a serious concern in industry and in the medical field. They are responsible for huge economical losses in many industrial sectors and for serious infections associated with biomaterial implants and medical devices. These infections are hard to treat because bacteria within the biofilm are more resistant to antibiotics and to the host immune system. Therefore, studying biofilm properties and mechanisms is of utmost relevance to develop efficient approaches

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Clark, Anne Lauren. "Detection and diagnosis of oral neoplasia with confocal microscopy and optical coherence microscopy." Thesis, 2003. http://wwwlib.umi.com/cr/utexas/fullcit?p3116288.

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Lu, Meng Hua, and 呂孟樺. "Integrated Optical Coherence Tomography with Laser Scanning Photoacoustic Microscopy." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/2yk8fv.

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碩士<br>國立清華大學<br>光電工程研究所<br>105<br>Optical coherence tomography is a promising biomedical imaging technique, which is widely used in ophthalmology and gastroenterology, etc. In recent years, there are several groups developing Fourier domain optical coherence tomography integrated with laser scanning photoacoustic microscopy since the Fourier domain optical coherence tomography and photoacoustic microscopy have the same scanning mechanism. However, in order to increase the field of view (FOV) of photoacoustic microscopy that it commonly uses an unfocused ultrasonic transducer. The signal-to-noi

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Yin, Biwei. "Optical coherence tomography for retinal diagnostics." Thesis, 2013. http://hdl.handle.net/2152/26614.

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Optical Coherence Tomography (OCT) is a non-invasive three-dimensional imaging technique. OCT synthesizes a cross-sectional image from a series of lateral adjacent depth scans, and with a two-dimensional scanning scheme, three-dimensional intensity image of sample can be constructed. Due to its non-invasive capability, OCT has been widely applied in ophthalmology, cardiology and dermatology; and in addition to three-dimensional intensity image construction, various functional OCT imaging techniques have been developed for clinical application. My research is focused on developing functional OC

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Lee, Cheng-Kang, and 李正綱. "System Integration of Spectral Domain Optical Coherence Tomography with Virtual Detector Laser-scanning Optical Resolution Photoacoustic Microscopy." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/dr8wf7.

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Tao, Yuankai Kenny. "Development of Coherence-Gated and Resolution-Multiplexed Optical Imaging Systems." Diss., 2010. http://hdl.handle.net/10161/3026.

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<p>Optical interrogation techniques are particularly well-suited for imaging tissue morphology, biological dynamics, and disease pathogenesis by providing noninvasive access to subcellular-resolution diagnostic information. State-of-the-art spectral domain optical coherence tomography (SDOCT) systems provide real-time optical biopsies of in vivo tissue, and have demonstrated clinical potential, particularly for applications in ophthalmology. </p><p>Recent advances in microscopy and endoscopy have led to improved resolution and compact optical designs, beyond those of conventional imaging syste

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Leung, Michael Ka Kit. "A Platform to Monitor Tumor Cellular and Vascular Response to Radiation Therapy by Optical Coherence Tomography and Fluorescence Microscopy in vivo." Thesis, 2010. http://hdl.handle.net/1807/25758.

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Radiotherapy plays a significant role in cancer treatment, and is thought to be curative by mainly killing tumor cells through damage to their genetic material. However, recent findings indicate that the tumor’s vascular blood supply is also a major determinant of radiation response. The goals of this thesis are to: (1) develop an experimental platform for small animals to deliver ionizing radiation and perform high-resolution optical imaging to treatment targets, and (2) use this toolkit to longitudinally monitor the response of tumors and the associated vasculature. The thesis has achieve

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Wang, Tianyi 1982. "Development and application of optical imaging techniques in diagnosing cardiovascular disease." Thesis, 2012. http://hdl.handle.net/2152/ETD-UT-2012-05-5215.

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Atherosclerosis and specifically rupture of vulnerable plaques account for 23% of all deaths worldwide, far surpassing both infectious diseases and cancer. Plaque-based macrophages, often associated with lipid deposits, contribute to atherogenesis from initiation through progression, plaque rupture and ultimately, thrombosis. Therefore, the macrophage is an important early cellular marker related to vulnerability of atherosclerotic plaques. The objective of my research is to assess the ability of multiple optical imaging modalities to detect, and further characterize the distribution of macrop

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Prem, Adrienne Marie. "Study of applications of second harmonic generation." Thesis, 2011. http://hdl.handle.net/2152/ETD-UT-2011-05-3572.

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Two applications of second harmonic generation (SHG), a nonlinear optical technique, are studied. First, Fresnel factors are used with a bond model to describe SHG from vicinal silicon at five incidence angles: 7.5°, 22°, 30°, 45°, and 52°. Second, a prototype apparatus for applying SHG to enhance imaging capabilities of optical coherence tomography, a microscopy technique used in many biological fields, is briefly described.<br>text

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