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Journal articles on the topic 'Optical coherence tomography and confocal microscopy'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Izatt, Joseph A., Manish Kulkarni, Hsing-Wen Wang, and Michael V. Sivak. "Optical Coherence Microscopy: A New Technique for High-Resolution, Non-Invasive Imaging in Bulk Biological Tissues." Microscopy and Microanalysis 3, S2 (1997): 795–96. http://dx.doi.org/10.1017/s1431927600010862.

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Optical coherence microscopy (OCM) is a novel technique complementary to optical coherence tomography (OCT) which combines low-coherence interferometry with confocal microscopy to achieve micron-scale resolution imaging in highly scattering media. OCM may be implemented using a single-mode fiber-optic low-coherence interferometer (See Fig. 1). A high numerical aperture objective is used to focus sample-arm light into the specimen, and the reference arm length of the interferometer is adjusted to match the sample arm focal plane optical depth. The sample arm of the interferometer comprises a sc
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2

Bohn, Sebastian, Karsten Sperlich, Heinrich Stolz, Rudolf F. Guthoff, and Oliver Stachs. "In vivo corneal confocal microscopy aided by optical coherence tomography." Biomedical Optics Express 10, no. 5 (2019): 2580. http://dx.doi.org/10.1364/boe.10.002580.

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3

WYLEGALA, E. "Confocal microscopy and optical coherence tomography imaging of corneal dystrophies." Acta Ophthalmologica 92 (August 20, 2014): 0. http://dx.doi.org/10.1111/j.1755-3768.2014.3635.x.

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4

Dadkhah, Arash, and Shuliang Jiao. "Integrating photoacoustic microscopy, optical coherence tomography, OCT angiography, and fluorescence microscopy for multimodal imaging." Experimental Biology and Medicine 245, no. 4 (2020): 342–47. http://dx.doi.org/10.1177/1535370219897584.

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We have developed a multimodal imaging system, which integrated optical resolution photoacoustic microscopy, optical coherence tomography, optical coherence tomography angiography, and confocal fluorescence microscopy in one platform. The system is able to image complementary features of a biological sample by combining different contrast mechanisms. We achieved fast imaging and large field of view by combining optical scanning with mechanical scanning, similar to our previous publication. We have demonstrated the capability of the multimodal imaging system by imaging a mouse ear in vivo. Impa
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5

Dalton, Kristine, Simone Schneider, Luigina Sorbara, and Lyndon Jones. "Confocal microscopy and optical coherence tomography imaging of hereditary granular dystrophy." Contact Lens and Anterior Eye 33, no. 1 (2010): 33–40. http://dx.doi.org/10.1016/j.clae.2009.09.005.

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6

Csuka, Ella A., Suzanne C. Ward, Chloe Ekelem, David A. Csuka, Marco Ardigò, and Natasha A. Mesinkovska. "Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis." Lasers in Surgery and Medicine 53, no. 6 (2021): 776–97. http://dx.doi.org/10.1002/lsm.23386.

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7

Tardif, Pier-Luc, Marie-Jeanne Bertrand, Maxime Abran, et al. "Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy." International Journal of Molecular Sciences 17, no. 12 (2016): 2110. http://dx.doi.org/10.3390/ijms17122110.

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8

Iftimia, Nicusor, R. Daniel Ferguson, Mircea Mujat, et al. "Combined reflectance confocal microscopy/optical coherence tomography imaging for skin burn assessment." Biomedical Optics Express 4, no. 5 (2013): 680. http://dx.doi.org/10.1364/boe.4.000680.

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9

Kang, Dongkyun, Melissa J. Suter, Caroline Boudoux, et al. "Combined Reflection Confocal Microscopy and Optical Coherence Tomography Imaging of Esophageal Biopsy." Gastrointestinal Endoscopy 69, no. 5 (2009): AB368. http://dx.doi.org/10.1016/j.gie.2009.03.1101.

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10

Gibson, Emily A., Omid Masihzadeh, Tim C. Lei, David A. Ammar, and Malik Y. Kahook. "Multiphoton Microscopy for Ophthalmic Imaging." Journal of Ophthalmology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/870879.

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We review multiphoton microscopy (MPM) including two-photon autofluorescence (2PAF), second harmonic generation (SHG), third harmonic generation (THG), fluorescence lifetime (FLIM), and coherent anti-Stokes Raman Scattering (CARS) with relevance to clinical applications in ophthalmology. The different imaging modalities are discussed highlighting the particular strength that each has for functional tissue imaging. MPM is compared with current clinical ophthalmological imaging techniques such as reflectance confocal microscopy, optical coherence tomography, and fluorescence imaging. In addition
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11

Touhami, S., L. Jouve, R. Atia, et al. "Optical coherence tomography and confocal microscopy aspects of a Schnyder's corneal dystrophy case." Journal Français d'Ophtalmologie 41, no. 5 (2018): e207-e209. http://dx.doi.org/10.1016/j.jfo.2018.02.002.

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12

Garbarino, F., S. Migliorati, F. Farnetani, et al. "Nodular skin lesions: correlation of reflectance confocal microscopy and optical coherence tomography features." Journal of the European Academy of Dermatology and Venereology 34, no. 1 (2019): 101–11. http://dx.doi.org/10.1111/jdv.15953.

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13

Cinotti, E., M. Espinasse, B. Labeille, F. Cambazard, and J. L. Perrot. "Dermoscopy, confocal microscopy and optical coherence tomography for the diagnosis of bedbug infestation." Journal of the European Academy of Dermatology and Venereology 31, no. 4 (2016): e203-e204. http://dx.doi.org/10.1111/jdv.13956.

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14

Siu, Gillian Denise Ji-Yee, Ka Wai Kam, and Alvin Lerrmann Young. "Amniotic Membrane Transplant for Bullous Keratopathy: Confocal Microscopy & Anterior Segment Optical Coherence Tomography." Seminars in Ophthalmology 34, no. 3 (2019): 163–67. http://dx.doi.org/10.1080/08820538.2019.1620790.

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15

Fuchs, Christine S. K., Amanda J. B. Andersen, Marco Ardigo, Peter A. Philipsen, Merete Haedersdal, and Mette Mogensen. "Acne vulgaris severity graded by in vivo reflectance confocal microscopy and optical coherence tomography." Lasers in Surgery and Medicine 51, no. 1 (2018): 104–13. http://dx.doi.org/10.1002/lsm.23008.

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16

Matoba, Ayumi, Yoshinori Oie, Honami Tanibuchi, Andrew Winegarner, and Kohji Nishida. "Anterior segment optical coherence tomography and in vivo confocal microscopy in cases of mucopolysaccharidosis." American Journal of Ophthalmology Case Reports 19 (September 2020): 100728. http://dx.doi.org/10.1016/j.ajoc.2020.100728.

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17

Tsoulnaras, Konstantinos I., Dimitrios A. Liakopoulos, Michael A. Grentzelos, Aristophanis I. Pallikaris, Dimitrios G. Mikropoulos, and George D. Kymionis. "Confocal Microscopy and Anterior Segment Optical Coherence Tomography Findings After Chemical Alkali Corneal Burn." Cornea 35, no. 10 (2016): e32-e35. http://dx.doi.org/10.1097/ico.0000000000000930.

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18

Badon, Amaury, Dayan Li, Geoffroy Lerosey, A. Claude Boccara, Mathias Fink, and Alexandre Aubry. "Smart optical coherence tomography for ultra-deep imaging through highly scattering media." Science Advances 2, no. 11 (2016): e1600370. http://dx.doi.org/10.1126/sciadv.1600370.

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Multiple scattering of waves in disordered media is a nightmare whether it is for detection or imaging purposes. So far, the best approach to get rid of multiple scattering is optical coherence tomography. This basically combines confocal microscopy and coherence time gating to discriminate ballistic photons from a predominant multiple scattering background. Nevertheless, the imaging-depth range remains limited to 1 mm at best in human soft tissues because of aberrations and multiple scattering. We propose a matrix approach of optical imaging to push back this fundamental limit. By combining a
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19

Romito, Norman, Liem Trinh, Isabelle Goemaere, Vincent Borderie, Laurent Laroche, and Nacim Bouheraoua. "Corneal Remodeling After Myopic SMILE: An Optical Coherence Tomography and In Vivo Confocal Microscopy Study." Journal of Refractive Surgery 36, no. 9 (2020): 597–605. http://dx.doi.org/10.3928/1081597x-20200713-01.

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20

Gaertner, Maria, Peter Cimalla, Sven Meissner, Wolfgang M. Kuebler, and Edmund Koch. "Three-dimensional simultaneous optical coherence tomography and confocal fluorescence microscopy for investigation of lung tissue." Journal of Biomedical Optics 17, no. 7 (2012): 071310. http://dx.doi.org/10.1117/1.jbo.17.7.071310.

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21

Szaflik, Jacek P., Monika Ołdak, Sława Kwiecień, Monika Udziela, and Jerzy Szaflik. "Optical Coherence Tomography and In Vivo Confocal Microscopy Features of Obstetric Injury of the Cornea." Cornea 27, no. 9 (2008): 1070–73. http://dx.doi.org/10.1097/ico.0b013e318172fbff.

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22

Giannakaki-Zimmermann, Helena, Despina Kokona, Sebastian Wolf, Andreas Ebneter, and Martin S. Zinkernagel. "Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography." Translational Vision Science & Technology 5, no. 4 (2016): 11. http://dx.doi.org/10.1167/tvst.5.4.11.

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23

Dembski, Michał, Anna Nowińska, Klaudia Ulfik, Sławomir Teper, and Edward Wylęgała. "In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography Analysis of the Microcystic Keratitis." Journal of Ophthalmology 2020 (December 17, 2020): 1–6. http://dx.doi.org/10.1155/2020/8871904.

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Purpose. To describe the findings of in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT) in a case of bilateral acute microcystic epitheliopathy after daily soft contact lens wear. Methods. IVCM and AS-OCT were used in the course of the bilateral epitheliopathy of a 23-year-old patient at the acute stage of the disease and at recovery after four days of treatment. The images were analyzed and compared. Results. On AS-OCT of the right eye, general hyperreflectivity and the increased thickness of the central corneal epithelium to 150 μm with numerous hyp
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24

Bazant-Hegemark, Florian, Katharine Edey, Gordon R. Swingler, Mike D. Read, and Nicholas Stone. "Review: Optical Micrometer Resolution Scanning for Non-invasive Grading of Precancer in the Human Uterine Cervix." Technology in Cancer Research & Treatment 7, no. 6 (2008): 483–96. http://dx.doi.org/10.1177/153303460800700610.

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Management of cervical precancer is archetypal for other cancer prevention programmes but has to consider diagnostic and logistic challenges. Numerous optical tools are emerging for non-destructive near real-time early diagnosis of precancerous lesions of the cervix. Non-destructive, real-time imaging modalities have reached pre-commercial status, but high resolution mapping tools are not yet introduced in clinical settings. The NCBI PubMed web page was searched using the keywords ‘CIN diagnosis’ and the combinations of ‘cervix {confocal, optical coherence tomography, ftir, infrared, Raman, vi
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25

Weissleder, Ralph, and Matthias Nahrendorf. "Advancing biomedical imaging." Proceedings of the National Academy of Sciences 112, no. 47 (2015): 14424–28. http://dx.doi.org/10.1073/pnas.1508524112.

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Imaging reveals complex structures and dynamic interactive processes, located deep inside the body, that are otherwise difficult to decipher. Numerous imaging modalities harness every last inch of the energy spectrum. Clinical modalities include magnetic resonance imaging (MRI), X-ray computed tomography (CT), ultrasound, and light-based methods [endoscopy and optical coherence tomography (OCT)]. Research modalities include various light microscopy techniques (confocal, multiphoton, total internal reflection, superresolution fluorescence microscopy), electron microscopy, mass spectrometry imag
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26

Jia, Pingping, Hong Zhao, and Yuwei Qin. "Laser Lens Size Measurement Using Swept-Source Optical Coherence Tomography." Applied Sciences 10, no. 14 (2020): 4936. http://dx.doi.org/10.3390/app10144936.

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A high-speed, high-resolution swept-source optical coherence tomography (SS-OCT) is presented for focusing lens imaging and a k-domain uniform algorithm is adopted to find the wave number phase equalization. The radius of curvature of the laser focusing lens was obtained using a curve-fitting algorithm. The experimental results demonstrate that the measuring accuracy of the proposed SS-OCT system is higher than the laser confocal microscope. The SS-OCT system has great potential for surface topography measurement and defect inspection of the focusing lens.
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27

Alafaleq, Munirah, Cristina Georgeon, Kate Grieve, and Vincent M. Borderie. "Multimodal imaging of pre-Descemet corneal dystrophy." European Journal of Ophthalmology 30, no. 5 (2019): 908–16. http://dx.doi.org/10.1177/1120672119862505.

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Purpose: The aim of this study was to assess structural and histological changes associated with pre-Descemet corneal dystrophy with multimodal in vivo imaging. Methods: Retrospective case series including eight corneas from four unrelated male patients with pre-Descemet corneal dystrophy characterized by the presence of punctiform gray opacities located just anterior to the Descemet membrane at slit-lamp examination of both eyes. In vivo confocal microscopy images were obtained in the central, paracentral, and peripheral corneal zones from the superficial epithelial cell layer down to the cor
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28

Ciancaglini, Marco, Paolo Carpineto, Luca Agnifili, et al. "Filtering Bleb Functionality: A Clinical, Anterior Segment Optical Coherence Tomography and In Vivo Confocal Microscopy Study." Journal of Glaucoma 17, no. 4 (2008): 308–17. http://dx.doi.org/10.1097/ijg.0b013e31815c3a19.

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29

Banzhaf, Christina A., Bas S. Wind, Mette Mogensen, et al. "Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy." Lasers in Surgery and Medicine 48, no. 2 (2015): 157–65. http://dx.doi.org/10.1002/lsm.22386.

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30

Iftimia, Nicusor, Gary Peterson, Ernest W. Chang, Gopi Maguluri, William Fox, and Milind Rajadhyaksha. "Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: anex vivostudy." Journal of Biomedical Optics 21, no. 1 (2016): 016006. http://dx.doi.org/10.1117/1.jbo.21.1.016006.

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31

Petrovic, Aleksandra, Kattayoon Hashemi, Frank Blaser, Wolfgang Wild, and George Kymionis. "Characteristics of Linear Interstitial Keratitis by In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography." Cornea 37, no. 6 (2018): 785–88. http://dx.doi.org/10.1097/ico.0000000000001552.

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32

Martone, Gianluca, Patrizia Pichierri, Rossella Franceschini, et al. "In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography in a Case of Alternaria Keratitis." Cornea 30, no. 4 (2011): 449–53. http://dx.doi.org/10.1097/ico.0b013e3181dae1f3.

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33

Bakhsh, Turki A., Alireza Sadr, Yasushi Shimada, Junji Tagami, and Yasunori Sumi. "Non-invasive quantification of resin–dentin interfacial gaps using optical coherence tomography: Validation against confocal microscopy." Dental Materials 27, no. 9 (2011): 915–25. http://dx.doi.org/10.1016/j.dental.2011.05.003.

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34

Cinotti, Elisa, Bruno Labeille, Catherine Douchet, Frédéric Cambazard, and Jean-Luc Perrot. "Dermoscopy, reflectance confocal microscopy, and high-definition optical coherence tomography in the diagnosis of generalized argyria." Journal of the American Academy of Dermatology 76, no. 2 (2017): S66—S68. http://dx.doi.org/10.1016/j.jaad.2016.07.057.

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35

Alarcon, Ivette, Johanna Brito, Llucia Alos, Josep Malvehy, and Susana Puig. "In vivo characterization of solitary angiokeratoma by reflectance confocal microscopy and high definition optical coherence tomography." Journal of the American Academy of Dermatology 72, no. 1 (2015): S43—S44. http://dx.doi.org/10.1016/j.jaad.2014.06.001.

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36

Bouheraoua, Nacim, Lea Jouve, Mohamed El Sanharawi, et al. "Optical Coherence Tomography and Confocal Microscopy Following Three Different Protocols of Corneal Collagen-Crosslinking in Keratoconus." Investigative Opthalmology & Visual Science 55, no. 11 (2014): 7601. http://dx.doi.org/10.1167/iovs.14-15662.

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37

Demirkilinc Biler, Elif, Suzan Guven Yilmaz, Melis Palamar, Pedram Hamrah, and Afsun Sahin. "In VivoConfocal Microscopy and Anterior Segment Optic Coherence Tomography Findings in Ocular Ochronosis." Case Reports in Ophthalmological Medicine 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/592847.

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Purpose. To report clinical andin vivoconfocal microscopy (IVCM) findings of two patients with ocular ochronosis secondary due to alkaptonuria.Materials and Methods. Complete ophthalmologic examinations, including IVCM (HRT II/Rostock Cornea Module, Heidelberg, Germany), anterior segment optical coherence tomography (AS-OCT) (Topcon 3D spectral-domain OCT 2000, Topcon Medical Systems, Paramus, NJ, USA), corneal topography (Pentacam, OCULUS Optikgeräte GmbH, Wetzlar, Germany), and anterior segment photography, were performed.Results. Biomicroscopic examination showed bilateral darkly pigmented
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38

Cole, Richard W., Carmen A. Mannella, Christian Renken, and James N. Turner. "Intermediate Magnification Imaging System for Whole Organs/Organisms." Microscopy Today 14, no. 6 (2006): 48–51. http://dx.doi.org/10.1017/s1551929500058892.

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There are many techniques for 3D imaging of biological specimens such as confocal, two-photon and, wide-field fluorescence microscopy, CAT scan, MRI, and optical coherence tomography. There are also many derivatives of these techniques, each having its strengths and weaknesses. Due to the differences in resolution, depth-of-field, and field-of-view, it is often difficult to compare images from the relatively high-resolution microscopy methods to the latter lower-resolution high-volume imaging methods. Effectively making this comparison could be very powerful in relating organ or organism level
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39

Gunzinger, Jeanne Martine, Nafsika Voulgari, Aleksandra Petrovic, Kattayoon Hashemi, and Georgios Kymionis. "Peripheral hypertrophic subepithelial corneal degeneration: clinical aspects related to in vivo confocal microscopy and optical coherence tomography." International Medical Case Reports Journal Volume 12 (July 2019): 237–41. http://dx.doi.org/10.2147/imcrj.s208297.

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40

Labbé, Antoine, Patrick Niaudet, Chantal Loirat, Marina Charbit, Geneviève Guest, and Christophe Baudouin. "In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography Analysis of the Cornea in Nephropathic Cystinosis." Ophthalmology 116, no. 5 (2009): 870–76. http://dx.doi.org/10.1016/j.ophtha.2008.11.021.

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41

Reinholz, Markus, Benjamin M. Clanner-Engelshofen, Markus V. Heppt, et al. "Successful Treatment of Genital Warts with Ingenol Mebutate Monitored with Optical Coherence Tomography and Reflectance Confocal Microscopy." Annals of Dermatology 31, no. 4 (2019): 434. http://dx.doi.org/10.5021/ad.2019.31.4.434.

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Bielicky, Lea, Markus Braun-Falco, Thomas Ruzicka, and Tanja Maier. "Aquagenic Wrinkling of the Palms: Morphological Changes in Reflectance Confocal Microscopy and High-Definition Optical Coherence Tomography." Dermatology 230, no. 3 (2015): 208–12. http://dx.doi.org/10.1159/000369165.

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43

Sattler, E., R. Kaestle, G. Rothmund, and J. Welzel. "Confocal laser scanning microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails." British Journal of Dermatology 166, no. 4 (2012): 740–46. http://dx.doi.org/10.1111/j.1365-2133.2011.10730.x.

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44

Li, Meiyan, Yu Zhao, Qirui Xiao, et al. "Demarcation Line in the Human Cornea After Surface Ablation Observed by Optical Coherence Tomography and Confocal Microscopy." Eye & Contact Lens: Science & Clinical Practice 44 (November 2018): S19—S23. http://dx.doi.org/10.1097/icl.0000000000000459.

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45

Hansen, Frederikke S., Emily Wenande, Merete Haedersdal, and Christine S. K. Fuchs. "Microneedle fractional radiofrequency‐induced micropores evaluated by in vivo reflectance confocal microscopy, optical coherence tomography, and histology." Skin Research and Technology 25, no. 4 (2019): 482–88. http://dx.doi.org/10.1111/srt.12676.

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46

Aleissa, Saud, Cristian Navarrete-Dechent, Miguel Cordova, et al. "Presurgical evaluation of basal cell carcinoma using combined reflectance confocal microscopy–optical coherence tomography: A prospective study." Journal of the American Academy of Dermatology 82, no. 4 (2020): 962–68. http://dx.doi.org/10.1016/j.jaad.2019.10.028.

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47

Sokolov, Konstantin, Kung-Bin Sung, Tom Collier, et al. "Endoscopic Microscopy." Disease Markers 18, no. 5-6 (2002): 269–91. http://dx.doi.org/10.1155/2002/251264.

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In vivo endoscopic optical microscopy provides a tool to assess tissue architecture and morphology with contrast and resolution similar to that provided by standard histopathology – without need for physical tissue removal. In this article, we focus on optical imaging technologies that have the potential to dramatically improve the detection, prevention, and therapy of epithelial cancers. Epithelial pre-cancers and cancers are associated with a variety of morphologic, architectural, and molecular changes, which currently can be assessed only through invasive, painful biopsy. Optical imaging is
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48

Marinova, Teodora L., Vesela Ivancheva, Svilena S. Peeva, and Christina N. Grupcheva. "Comparison of Four Methods for Corneal Thickness Measurement." Journal of Biomedical and Clinical Research 6, no. 1 (2013): 37–42. http://dx.doi.org/10.1515/jbcr-2015-0101.

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Summary The aim of the study was to evaluate the thickness of the normal cornea in order to establish correlation between four methods of measuring including: ultrasound pachymetry (USP), anterior segment optical coherence tomography (ASOCT), non-contact tono/pachymetry (TONOPACHY) and laser-scanning confocal microscopy (LSCM). The study was based on evaluating repeatability and comparability of four different methods formeasuring the corneal thickness. Non contact specular microscopy was first performed on all 27 patients (aged between 20 and 24 years) to evaluate corneal characteristics and
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Ozgurhan, Engin Bilge, Betul Ilkay Sezgin Akcay, Yusuf Yildirim, Gonul Karatas, Tugba Kurt, and Ahmet Demirok. "Evaluation of Corneal Stromal Demarcation Line after Two Different Protocols of Accelerated Corneal Collagen Cross-Linking Procedures Using Anterior Segment Optical Coherence Tomography and Confocal Microscopy." Journal of Ophthalmology 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/981893.

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Purpose. To evaluate the depth of corneal stromal demarcation line using AS-OCT and confocal microscopy after two different protocols of accelerated corneal collagen cross-linking procedures (CXL).Methods. Patients with keratoconus were divided into two groups. Peschke CXL device (Peschke CCL-VARIO Meditrade GmbH) applied UVA light with an intended irradiance of 18.0 mW/cm2for 5 minutes after applying riboflavin for 20 minutes (group 1) and 30 minutes (group 2). One month postoperatively, corneal stromal demarcation line was measured using AS-OCT and confocal microscopy.Results. This study enr
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50

Chan, Tommy C. Y., Kelvin H. Wan, Kendrick C. Shih, and Vishal Jhanji. "Advances in dry eye imaging: the present and beyond." British Journal of Ophthalmology 102, no. 3 (2017): 295–301. http://dx.doi.org/10.1136/bjophthalmol-2017-310759.

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New advances in imaging allow objective measurements for dry eye as well as define new parameters that cannot be measured by clinical assessment alone. A combination of these modalities provides unprecedented information on the static and dynamic properties of the structural and functional parameters in this multifactorial disease. A literature search was conducted to include studies investigating the use of imaging techniques in dry eye disease. This review describes the application of non-invasive tear breakup time, optical coherence tomography, meibomian gland imaging, interferometry, in vi
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