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Journal articles on the topic 'Optical toxicities'

Author: Grafiati

Published: 15 February 2025

Last updated: 31 July 2025

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1

Yohan, Darren, Anthony Kim, Elina Korpela, et al. "Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy." Biomedical Optics Express 5, no. 5 (2014): 1309. http://dx.doi.org/10.1364/boe.5.001309.

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Bradford, Chairman, Robert W., and Curriculum Oversight. "High Resolution Optical Microscopy Will Play a Major Role in Functional Assessments and the Prevention of Disease." Microscopy and Microanalysis 6, S2 (2000): 834–35. http://dx.doi.org/10.1017/s1431927600036667.

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The typical aging processes can be characterized by a gradual alteration and essential breakdown of the functional systems of the body. Numerous factors play important roles in the alterations of these pathways from biochemical individuality and genetic predisposition to environmental insults and deficiency states.1 Clinical research, as but one example, has clearly documented the role of free radicals (ROS) or oxidative injury in disease and aging affecting the body's basic cellular structures.The objective of functional or health assessments is to be able to detect in vivo stresses and imbal

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Futra, Dedi, Lee Heng, Asmat Ahmad, Salmijah Surif, and Tan Ling. "An Optical Biosensor from Green Fluorescent Escherichia coli for the Evaluation of Single and Combined Heavy Metal Toxicities." Sensors 15, no. 6 (2015): 12668–81. http://dx.doi.org/10.3390/s150612668.

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Colaço, Raul, Mariana Portela, Ilda Costa, Marta Guedes, and António Mota. "Radiotherapy as Salvage Treatment in Intraocular Lymphoma: A Case Report." Case Reports in Oncology 14, no. 1 (2021): 184–89. http://dx.doi.org/10.1159/000512216.

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A 67-year-old previously healthy woman presented with progressive visual impairment including bitemporal hemianopsia. A brain magnetic resonance imaging revealed a contrast-enhancing mass in the optic chiasm, spreading along the left optic tract. The patient underwent a transcranial biopsy of the left optical tract that yielded a diagnosis of diffuse large B-cell lymphoma. CT scans of the chest, abdomen, and pelvis, PET-CT, and bone marrow biopsy revealed no evidence of systemic lymphoma. Thus, the final diagnosis was of primary central nervous system lymphoma of the optic chiasm. Systemic tre

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Capitini, Claudia, Jayneil R. Patel, Antonino Natalello, et al. "Structural differences between toxic and nontoxic HypF-N oligomers." Chemical Communications 54, no. 62 (2018): 8637–40. http://dx.doi.org/10.1039/c8cc03446j.

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Xing, Lei, Jia-Liang Zhang, Tian-jiao Zhou, et al. "A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy." Chemical Communications 54, no. 63 (2018): 8737–40. http://dx.doi.org/10.1039/c8cc03720e.

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A polynuclear nanoparticle fabricated through a sequential hydrophobic and electrostatic interaction mechanism can circumvent the contradictory problem of siRNA binding capacity and toxicities of cationic vectors.

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Yang, Han Yu. "Lanthanide-Based Nanoprobes for Time-Resolved Luminescence Imaging on Various Ions and Molecules." Materials Science Forum 1075 (November 30, 2022): 9–17. http://dx.doi.org/10.4028/p-76fds1.

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Lanthanide-doped upconversion nanoparticles (Ln-UCNPs) have been extensively explored in the biological field. In particular, Ln-UCNPs with near-infrared (NIR) fluorescence have tremendous potential for biological imaging because of their outstanding photo-and chemo-stability, extended photoluminescence lifetimes, low long-term toxicities and narrow photoluminescence bandwidths as well as minimal background interferences. Using predesigned energy transfer routes makes it possible to get upconversion luminescence from lanthanides' 4f-4f optical transitions. This article clarifies the key workin

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Dang, Xiangnan, Li Gu, Jifa Qi, et al. "Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer." Proceedings of the National Academy of Sciences 113, no. 19 (2016): 5179–84. http://dx.doi.org/10.1073/pnas.1521175113.

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Fluorescence imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing tissue autofluorescence. Here, NIR-II fluorescent probes, including down-conversion nanoparticles, quantum dots, single-walled carbon nanotubes, and organic dyes, are constructed into biocompatible nanoparticles using the layer-by-layer (LbL) platform due to its modular and versatile nature. The LbL platform has previously been demonstrated to enable incorporation of diagnostic agents, drugs, and nucleic acids such as siRNA while providin

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Maryam, Bushra, Yi Wang, Xiaoran Li, et al. "Luminous Upconverted Nanoparticles as High-Sensitivity Optical Probes for Visualizing Nano- and Microplastics in Caenorhabditis elegans." Sensors 25, no. 11 (2025): 3306. https://doi.org/10.3390/s25113306.

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With the increasing prevalence of plastic pollution, understanding its impact on soil nematodes is crucial for environmental sustainability and food security. Traditional fluorescence-based probes have the limitations of high background noise and interference from autofluorescence. In this study, the luminous upconverted NaYF4:Yb3+/Er3+ nanoparticles acted as high-sensitivity probes for real-time visualization of ingestion and biodistribution of polystyrene microplastics (PS-MPs) and nanoplastics (PS-NPs) in Caenorhabditis elegans. The novel probes enabled efficient near-infrared-to-visible li

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Alfei, Silvana, and Gian Carlo Schito. "Antimicrobial Nanotubes: From Synthesis and Promising Antimicrobial Upshots to Unanticipated Toxicities, Strategies to Limit Them, and Regulatory Issues." Nanomaterials 15, no. 8 (2025): 633. https://doi.org/10.3390/nano15080633.

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Nanotubes (NTs) are nanosized tube-like structured materials made from various substances such as carbon, boron, or silicon. Carbon nanomaterials (CNMs), including carbon nanotubes (CNTs), graphene/graphene oxide (G/GO), and fullerenes, have good interatomic interactions and possess special characteristics, exploitable in several applications because of the presence of sp2 and sp3 bonds. Among NTs, CNTs are the most studied compounds due to their nonpareil electrical, mechanical, optical, and biomedical properties. Moreover, single-walled carbon nanotubes (SWNTs) have, in particular, demonstra

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Ray, Shariqsrijon Sinha, and Jayita Bandyopadhyay. "Nanotechnology-enabled biomedical engineering: Current trends, future scopes, and perspectives." Nanotechnology Reviews 10, no. 1 (2021): 728–43. http://dx.doi.org/10.1515/ntrev-2021-0052.

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Abstract Applications of nanotechnology in biomedical engineering are vast and span several interdisciplinary areas of nanomedicine, diagnostics, and nanotheranostics. Herein, we provide a brief perspective on nanotechnology as an enabling tool for the design of new functional materials and devices for medical applications. Semiconductor nanocrystals, also known as quantum dots, are commonly used in optical imaging to diagnose diseases such as cancer. Varieties of metal and metal oxide nanoparticles, and two-dimensional carbon-based nanostructures, are prospective therapeutics and may also be

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Jia, Qi, Nana Xu, Pengqian Mu, Bo Wang, Shuming Yang, and Jing Qiu. "Stereoselective Separation and Acute Toxicity of Tau-Fluvalinate to Zebrafish." Journal of Chemistry 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/931908.

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Tau-fluvalinate (TFLV) is one of the most potent chiral synthetic pyrethroids to control a wide range of pests in agricultural fields, especially in apiary. In this study, two stereoisomers of TFLV were fully separated by high-performance liquid chromatography (HPLC) with a semipreparative chiral column using cellulose-tris(3,5-dimethylphenylcarbamate) as chiral stationary phase andn-hexane and 2-propanol (96/4, v/v) as mobile phase at a flow rate of 2.5 mL min−1. The (+)-stereoisomer was first eluted by detecting with an optical rotation detector. After obtaining pure single stereoisomer of T

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Bucur (Popa), Raluca Maria, Cristiana Radulescu, Ioana Daniela Dulama, et al. "Potential Health Risk of Microplastic Exposures from Skin-Cleansing Products." Toxics 13, no. 5 (2025): 354. https://doi.org/10.3390/toxics13050354.

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This research aims to investigate and quantify the possible presence of microplastics (MPs) in usual skin-cleansing products (i.e., liquid soap, micellar water, and micellar cleansing oil), the most popular from the market in terms of brand and customer confidence. Therefore, optical microscopy and micro-Fourier transform infrared spectroscopy (micro-FTIR) were used to determine the MPs’ number, color, shape, size, and chemical composition. For the first time, the results were correlated with the possible exposure paths (i.e., inhalation, ingestion, or adsorption) to assess the human health ri

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Kim, Sang Ho, Chanchal Sharma, Imran Khan, and Sun Chul Kang. "Breeding of zebrafish in the laboratory environment for research development." Bangladesh Journal of Pharmacology 12, no. 4 (2017): 434. http://dx.doi.org/10.3329/bjp.v12i4.34143.

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<p>The zebrafish (<em>Danio rerio</em>) has turn out to be an excellent vertebrate organism for analyzing developmental stages, disease modeling, and screening of drug toxicities due to their minuscule, high fecundity, optical transparency and there close parallels with the genome of human beings. Although maintenance of zebrafish is relatively easy, yet it is a complex process, greatly influenced by various factors including mating behavior, day-light cycle, age, and size of fish. This visual experiment will provide an overview of zebrafish care and maintenance in the labora

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Fasolino, Giuseppe, Laura Moschetta, Jacques De Grève, Pieter Nelis, Pierre Lefesvre, and Marcel Ten Tusscher. "Choroidal and Choriocapillaris Morphology in Pan-FGFR Inhibitor-Associated Retinopathy: A Case Report." Diagnostics 12, no. 2 (2022): 249. http://dx.doi.org/10.3390/diagnostics12020249.

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Emerging anticancer agents such as the pan-FGFR Inhibitor have achieved remarkable improvements in the survival of patients with metastatic malignancies. Nevertheless they are still associated with specific ophthalmic toxicities. Understanding their pathophysiology can lead us to better clinical practice of life-threatening and vision-threatening circumstances. To investigate choroidal alterations as a potential pathophysiological mechanism of a serous detachment in bilateral pan-FGFR Inhibitor-Associated Retinopathy (FGFRAR), the morphology of the choroid and choriocapillaris were assessed. T

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Foulet, Amandine, Ouahid Ben Ghanem, Mohanad El-Harbawi, Jean-Marc Lévêque, M. I. Abdul Mutalib, and Chun-Yang Yin. "Understanding the physical properties, toxicities and anti-microbial activities of choline-amino acid-based salts: Low-toxic variants of ionic liquids." Journal of Molecular Liquids 221 (September 2016): 133–38. http://dx.doi.org/10.1016/j.molliq.2016.05.046.

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17

Di Nicola, Maura, Giulio Barteselli, Laura Dell’Arti, Roberto Ratiglia, and Francesco Viola. "Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature." BioMed Research International 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/249617.

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Deferoxamine mesylate (DFO) is the most commonly used iron-chelating agent to treat transfusion-related hemosiderosis. Despite the clear advantages for the use of DFO, numerous DFO-related systemic toxicities have been reported in the literature, as well as sight-threatening ocular toxicity involving the retinal pigment epithelium (RPE). The damage to the RPE can lead to visual field defects, color-vision defects, abnormal electrophysiological tests, and permanent visual deterioration. The purpose of this review is to provide an updated summary of the ocular findings, including both functional

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Gootenberg, Joseph E., and Philip A. Pizzo. "Optimal Management of Acute Toxicities of Therapy." Pediatric Clinics of North America 38, no. 2 (1991): 269–97. http://dx.doi.org/10.1016/s0031-3955(16)38078-6.

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Rahmani, Reyhaneh, Mohsen Gharanfoli, Mehran Gholamin, et al. "Plant-mediated synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) using aloe vera and flaxseed extracts and evaluation of their cellular toxicities." Ceramics International 46, no. 3 (2020): 3051–58. http://dx.doi.org/10.1016/j.ceramint.2019.10.005.

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20

Liu, Chusheng, Yanjing Wang, Gaofei Zhang, et al. "Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics." Toxics 10, no. 6 (2022): 276. http://dx.doi.org/10.3390/toxics10060276.

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Gold nanomaterials (Au NMs) have been widely used in cosmetic products for improving the brightening, and reducing the wrinkling of, skin, etc.; however, the dermal safety of Au NMs is rarely concerned. A previous study found that cosmetics could enhance the toxicity of Au nanosheets, but different physicochemical properties of Au NMs will induce different interaction modes with ingredients of cosmetics, potentially leading to different toxicity profiles. In the present study, spherical and rodlike Au NMs were first found in commercial cosmetics, and then Au nanospheres (NSs) with different si

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Mirandola, Alfredo, Stefania Russo, Maria Bonora, et al. "A Patient Selection Approach Based on NTCP Models and DVH Parameters for Definitive Proton Therapy in Locally Advanced Sinonasal Cancer Patients." Cancers 14, no. 11 (2022): 2678. http://dx.doi.org/10.3390/cancers14112678.

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(1) Background: In this work, we aim to provide selection criteria based on normal tissue complication probability (NTCP) models and additional explanatory dose-volume histogram parameters suitable for identifying locally advanced sinonasal cancer patients with orbital invasion benefitting from proton therapy. (2) Methods: Twenty-two patients were enrolled, and two advanced radiation techniques were compared: intensity modulated proton therapy (IMPT) and photon volumetric modulated arc therapy (VMAT). Plans were optimized with a simultaneous integrated boost modality: 70 and 56 Gy(RBE) in 35 f

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Shabir, Shabnam, Amit Sehgal, Joydeep Dutta, et al. "Therapeutic Potential of Green-Engineered ZnO Nanoparticles on Rotenone-Exposed D. melanogaster (Oregon R+): Unveiling Ameliorated Biochemical, Cellular, and Behavioral Parameters." Antioxidants 12, no. 9 (2023): 1679. http://dx.doi.org/10.3390/antiox12091679.

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Nanotechnology holds significant ameliorative potential against neurodegenerative diseases, as it can protect the therapeutic substance and allow for its sustained release. In this study, the reducing and capping agents of Urtica dioica (UD), Matricaria chamomilla (MC), and Murraya koenigii (MK) extracts were used to synthesize bio-mediated zinc oxide nanoparticles (ZnO-NPs) against bacteria (Staphylococcus aureus and Escherichia coli) and against rotenone-induced toxicities in D. melanogaster for the first time. Their optical and structural properties were analyzed via FT-IR, DLS, XRD, EDS, S

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Biswal, Manas R., Ryan J. Paulson, Riddhi Vichare, and Alfred S. Lewin. "Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium." Antioxidants 12, no. 12 (2023): 2129. http://dx.doi.org/10.3390/antiox12122129.

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Chronic oxidative stress impairs the normal functioning of the retinal pigment epithelium (RPE), leading to atrophy of this cell layer in cases of advance age-related macular degeneration (AMD). The purpose of our study was to determine if buspirone, a partial serotonin 1A (5-HT1A) receptor agonist, protected against oxidative stress-induced changes in the RPE. We exposed differentiated human ARPE-19 cells to paraquat to induce oxidative damage in culture, and utilized a mouse model with sodium iodate (NaIO3)-induced oxidative injury to evaluate the effect of buspirone. To investigate buspiron

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Williams, Wesley Allen, and Shyam Aravamudhan. "Micro-Nanoparticle Characterization: Establishing Underpinnings for Proper Identification and Nanotechnology-Enabled Remediation." Polymers 16, no. 19 (2024): 2837. http://dx.doi.org/10.3390/polym16192837.

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Microplastics (MPLs) and nanoplastics (NPLs) are smaller particles derived from larger plastic material, polymerization, or refuse. In context to environmental health, they are separated into the industrially-created “primary” category or the degradation derivative “secondary” category where the particles exhibit different physiochemical characteristics that attenuate their toxicities. However, some particle types are more well documented in terms of their fate in the environment and potential toxicological effects (secondary) versus their industrial fabrication and chemical characterization (

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Zheng, Liyun, and Jiansong Ji. "Magnesium microspheres to enhance lipiodol-mediated transarterial chemo-embolization (TACE) of hepatocellular carcinoma: From bench to a pilot clinical study." Journal of Clinical Oncology 42, no. 16_suppl (2024): e16204-e16204. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e16204.

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e16204 Background: Transarterial chemoembolization (TACE) has been extensively used in clinic to treat unresectable hepatocellular carcinoma (HCC). However, arterial embolization would worsen the hostile physicochemical features in the tumor microenvironment (TME) by further reducing its pH and increasing hypoxia, leading to immunosuppressive TME and drug resistance. Methods: Magnesium microspheres (Mg MSs), acting as H2 donors and pH modulators, were prepared via gas atomization pulverization. Characterization included inverted optical microscopy, SEM, and XRD analysis. Their H2 generation an

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Qiu, Xudong, Seth T. Gammon, Carol Rasmussen, et al. "In vivo scanning laser fundus and high-resolution OCT imaging of retinal ganglion cell injury in a non-human primate model with an activatable fluorescent-labeled TAT peptide probe." PLOS ONE 19, no. 12 (2024): e0313579. https://doi.org/10.1371/journal.pone.0313579.

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The optical imaging agent TcapQ488 has enabled imaging of retinal ganglion cell (RGC) injury in vivo in rodents and has potential as an effective diagnostic probe for early detection and intervention monitoring in glaucoma patients. In the present study, we investigated TcapQ488 in non-human primates (NHPs) to identify labeling efficacy and early signals of injured RGC, to determine species-dependent changes in RGC probe uptake and clearance, and to determine dose-limiting toxicities. Doses of 3, 6, and 12 nmol of TcapQ488 were delivered intravitreally to normal healthy NHP eyes and eyes that

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Weakland, Tina, and Henry Wagner. "Management of Toxicities of Combined Modality Therapy for Intrathoracic Malignancies." Cancer Control 3, no. 4 (1996): 329–35. http://dx.doi.org/10.1177/107327489600300404.

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Background Combined radiation and chemotherapy for intrathoracic tumors can produce appreciable morbidity. Apprehension about the severity of these toxicities may inhibit optimal patient care. Methods The literature on recognition, diagnosis, prophylaxis, and management of these toxicities is reviewed and combined with the experiences of the authors to produce management recommendations. Results Toxicities include acute and chronic esophagitis, early and late pneumonitis with fibrosis, myelosuppression, and neurologic deficits. Measures are available to minimize their severity and to reduce th

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Lee, Shing M., Daniel Backenroth, Ying Kuen Ken Cheung, et al. "Case Example of Dose Optimization Using Data From Bortezomib Dose-Finding Clinical Trials." Journal of Clinical Oncology 34, no. 12 (2016): 1395–401. http://dx.doi.org/10.1200/jco.2015.66.0662.

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Purpose The current dose-finding methodology for estimating the maximum tolerated dose of investigational anticancer agents is based on the cytotoxic chemotherapy paradigm. Molecularly targeted agents (MTAs) have different toxicity profiles, which may lead to more long-lasting mild or moderate toxicities as well as to late-onset and cumulative toxicities. Several approved MTAs have been poorly tolerated during long-term administration, leading to postmarketing dose optimization studies to re-evaluate the optimal treatment dose. Using data from completed bortezomib dose-finding trials, we explo

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Mucha, Simon R., and Prabalini Rajendram. "Management and Prevention of Cellular-Therapy-Related Toxicity: Early and Late Complications." Current Oncology 30, no. 5 (2023): 5003–23. http://dx.doi.org/10.3390/curroncol30050378.

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Chimeric Antigen Receptor T (CAR-T) cell therapy has dramatically changed prognosis and treatment of relapsed and refractory hematologic malignancies. Currently the 6 FDA approved products target various surface antigens. While CAR-T therapy achieves good response, life-threatening toxicities have been reported. Mechanistically, can be divided into two categories: (1) toxicities related to T-cell activation and release of high levels of cytokines: or (2) toxicities resulting from interaction between CAR and CAR targeted antigen expressed on non-malignant cells (i.e., on-target, off-tumor effec

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Howell, Matthew, Rebecca Lee, Samantha Bowyer, Alberto Fusi, and Paul Lorigan. "Optimal management of immune-related toxicities associated with checkpoint inhibitors in lung cancer." Lung Cancer 88, no. 2 (2015): 117–23. http://dx.doi.org/10.1016/j.lungcan.2015.02.007.

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Gresham, Gillian, Jasleen Sidhu, Navraj Malhi, and Winson Y. Cheung. "Predicting toxicities from adjuvant treatment in a population-based cohort of early colon cancer (CC) patients (pts): A strategy to improve use of curative chemotherapy." Journal of Clinical Oncology 32, no. 3_suppl (2014): 412. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.412.

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412 Background: CC pts treated with chemotherapy are at risk of experiencing a number of toxicities. The identification of pts who may be at a higher risk of developing toxicities allows clinicians to be more vigilant in preventing and managing side effects early, thus enabling more optimal delivery of chemotherapy. Our aim was to determine clinical factors associated with toxicities from adjuvant FOLFOX in early CC. Methods: Pts diagnosed with stage III CC from 2005 to 2008, seen at any 1 of 5 regional cancer centers of the British Columbia Cancer Agency, and treated with adjuvant FOLFOX chem

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Snider, Kelly L., and Michael L. Maitland. "Cardiovascular toxicities: clues to optimal administration of vascular endothelial growth factor signaling pathway inhibitors." Targeted Oncology 4, no. 2 (2009): 67–76. http://dx.doi.org/10.1007/s11523-009-0106-0.

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Martín, Antonio González. "Safety Profile of Trabectedin in Combination With Liposomal Pegylated Doxorrubicin in Relapsed Ovarian Carcinoma: Considerations for Optimal Management." International Journal of Gynecologic Cancer 21, Supp 1 (2011): S6—S8. http://dx.doi.org/10.1097/igc.0b013e318217b360.

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The toxicity profile of trabectedin in the OVA-301 trial, that combined trabectedin with pegylated liposomal doxorubicin for the treatment of patients with ovarian cancer, has shown to be predictable and manageable. No unexpected toxicities were found, with neutropenia and transient increase in transaminases as the most common adverse events reported. The elevation in transaminases appeared early and generally decreased in incidence and intensity over subsequent cycles, with no major clinical consequences. A similar safety profile was seen in the analysis of the older patients in the trial. Th

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Dulong, Sandrine, Lucas Eduardo Botelho de Souza, Jean Machowiak, et al. "Sex and Circadian Timing Modulate Oxaliplatin Hematological and Hematopoietic Toxicities." Pharmaceutics 14, no. 11 (2022): 2465. http://dx.doi.org/10.3390/pharmaceutics14112465.

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Oxaliplatin was nearly twice as hematotoxic, with optimal circadian timing differing by 6 h, in women as compared to men with colorectal cancers. Hence, we investigated sex- and timing-related determinants of oxaliplatin hematopoietic toxicities in mice. Body-weight loss (BWL), blood cell counts, bone marrow cellularity (BMC) and seven flow-cytometry-monitored hematopoietic progenitor populations were evaluated 72 h after oxaliplatin chronotherapy administration (5 mg/kg). In control animals, circadian rhythms of circulating white blood cells showed a peak at ZT5 in both sexes, whereas BMC was

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Vanderburg, Sky Breeden, A. Lindsay Frazier, and Jane Kim. "Determining optimal first-line chemotherapy for good and intermediate prognosis testicular germ cell tumors using decision analysis." Journal of Clinical Oncology 32, no. 30_suppl (2014): 209. http://dx.doi.org/10.1200/jco.2014.32.30_suppl.209.

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209 Background: Since 80-90% of testicular germ cell tumors (GCTs) are cured after first line therapy alone, minimizing toxicity should be an important consideration in the initial treatment decision between cisplatin and carboplatin. Cisplatin has been shown to be superior in 5-year disease-free survival, but cisplatin use confers a higher risk of key long-term toxicities. This study aims to quantify this trade-off between disease-free survival and toxicities using decision analysis. Methods: We developed a mathematical decision-analytic model that simulates competing strategies of initial tr

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Webb, Philip, Terry W. Rice, and Timothy Cooksley. "Problem-based review: Immune-mediated complications of ‘Checkpoint Inhibitors’ for the Acute Physician." Acute Medicine Journal 16, no. 1 (2017): 21–24. http://dx.doi.org/10.52964/amja.0647.

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Immunotherapy with ’checkpoint-inhibitors‘ has significantly improved outcomes for patients with a range of malignancies. However, significant immune-mediated toxicities of these therapies are well-described. These immune-mediated toxicities can affect virtually all organ systems and are potentially fatal. The timing of onset of the adverse effects is dependent on the organ system affected and can occur after completion of the treatment. The increasing utilisation of ‘checkpoint-inhibitors’ means that Acute Physicians are likely to see a number of immune-mediated complications presenting to th

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Ribeiro, Andreza Alice Feitosa. "Follow–up beyond 1 month after autologous CAR T cell therapy." JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY 3, no. 2 (2022): 181. http://dx.doi.org/10.46765/2675-374x.2022v3n2p181.

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The incidence of medium-term and long-term adverse events are critical factors determining the utility of CAR T-cell therapy and research of risk factors and timeline of late effects will be critical for optimal survivorship care. The most commonly reported toxicities during long-term follow-up after anti-CD19 CAR T-cell therapy are decreased blood B-cell counts, hypogammaglobulinemia, prolonged cytopenias and infections. Common determinants of late toxicities are age, underlying tumor type, previous therapy and CAR construct. Here we will provide some recommendations for patient monitoring du

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Chitsazan, Mandana, Ahmad Amin, Luisa Ladel, Alyza Baig, and Mitra Chitsazan. "Cardiovascular Toxicity Associated With Immune Checkpoint Inhibitor Therapy: A Comprehensive Review." Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine 22, no. 3 (2023): 69–82. http://dx.doi.org/10.1097/hpc.0000000000000327.

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Immune checkpoint inhibitors (ICIs), a significant breakthrough treatment of cancer, exert their function through enhancing the immune system’s ability to recognize and attack cancer cells. However, these revolutionary cancer treatments have been associated with a range of immune-related adverse effects, including cardiovascular toxicity. The most commonly reported cardiovascular toxicities associated with ICIs are myocarditis, pericarditis, arrhythmias, and vasculitis. These cardiovascular manifestations are often severe and can lead to life-threatening complications. Therefore, prompt identi

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Farhadfar, Nosha, Jack W. Hsu, Brent R. Logan, et al. "Weighty Choices: Selecting Optimal G-CSF Doses for Stem Cell Mobilization to Optimize Yield." Blood 132, Supplement 1 (2018): 193. http://dx.doi.org/10.1182/blood-2018-193.

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Abstract Introduction. There is little information on the effect of donor body mass index (BMI) on mobilization response to Filgrastim (G-CSF), especially in the unrelated donor setting. Obesity has been associated with chronic low-grade inflammation due to chronic activation of the innate immune system. Obesity-induced pro-inflammatory cytokines can interfere with bone marrow SDF1/CXCR4 axis and promote mobilization of progenitor cells leading to persistent leukocytosis and an increase in number of circulating progenitor cells. Given a higher number of circulatory progenitor cells in obese in

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Sayed, Ahmed, Malak Munir, Sanam Ghazi, et al. "Cardiovascular Toxicities Associated with Bispecific T-Cell Engagers." Blood 142, Supplement 1 (2023): 2882. http://dx.doi.org/10.1182/blood-2023-189603.

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Background: Bispecific T-cell engagers (BTEs) are a novel class of drugs used to treat hematological malignancies that link endogenous tumor antigens to CD3 on the T-cell receptor, priming circulating T-cells to effectively target tumor cells. Although chimeric antigen receptor T-cell therapies, a closely related class, have been associated with cardiovascular toxicity, little is known about the cardiovascular toxicity of BTEs. As early clinical trials may have been underpowered for the detection of cardiovascular adverse events (CVAEs), we conducted a large-scale post-marketing surveillance s

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Advani, Anjali S. "Biology and Treatment of Acute Lymphocytic Leukemia in Adolescents and Young Adults." American Society of Clinical Oncology Educational Book, no. 33 (May 2013): 285–89. http://dx.doi.org/10.14694/edbook_am.2013.33.285.

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The treatment of young adults (16 to 39 years of age) with acute lymphocytic leukemia (ALL) has been a focus of clinical research over the past decade. This review will focus on the biology, optimal treatment, treatment-related toxicities, and psychosocial issues in this patient population.

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Oza, Aabha, Patrick Grierson, Sean Glasgow, et al. "A phase I dose-escalation trial of intraperitoneal oxaliplatin with systemic capecitabine and bevacizumab following cytoreduction in patients with peritoneal carcinomatosis from appendiceal or colorectal cancer." Journal of Clinical Oncology 36, no. 4_suppl (2018): 746. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.746.

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746 Background: Peritoneal carcinomatosis (PC) is the intraperitoneal spread of cancer. Optimal treatment for PC is controversial. Systemic chemotherapy offers limited benefit (Franko, 2011). Intraperitoneal (IP) chemotherapy following cytoreductive surgery (CRS) improves outcomes (Verwaal, 2008). Oxaliplatin (Ox), capecitabine, and bevacizumab are standard agents for the treatment of metastatic colorectal cancer (CRC). Evidence suggests benefit of IP Ox at high doses. However, the optimal dose of IP Ox combined with standard systemic therapy is unclear. Methods: We conducted an IRB-approved p

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Kantor, Elizabeth, Kelli O'Connell, Jenna Bhimani, et al. "Obesity, chemotherapy dosing, and toxicity: Results from the Optimal Breast Cancer Chemotherapy Dosing study." Journal of Clinical Oncology 43, no. 16_suppl (2025): 547. https://doi.org/10.1200/jco.2025.43.16_suppl.547.

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547 Background: ASCO guidelines state that most cytotoxic drugs should be dosed according to full body surface area (BSA) without limiting the dose on the basis of obesity. This approach is supported by a lack of evidence to suggest that patients with obesity, when fully-dosed, experience higher risk of toxicity. Indeed, historical evidence suggests that obese, fully-dosed patients may experience lower risk of neutropenia than normal weight patients. However, questions remain regarding the representativeness of historical trial data on which this evidence is based. We examined this issue in th

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Mercier, C., C. Brunet, C. Yang, et al. "Pharmacoeconomic study in head and neck cancer patients: Impact of prospective DPD deficiency screening with 5-fluorouracil (5-FU) dose tailoring on toxicities-related costs." Journal of Clinical Oncology 27, no. 15_suppl (2009): 6515. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6515.

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6515 Background: Dihydropyrimidine dehydrogenase (DPD) plays a pivotal role in the detoxification of 5-FU. We studied the impact of screening DPD impairment in head and neck cancer (HNC) patients, both on reduction of drug-related toxicities and as a pharmacoeconomic endpoint. Methods: A total of 148 consecutive patients with HNC treated with 5-FU+platinum were monitored. Seventy-four patients (Arm A - before 2006) were treated with standard dosage, whereas 74 other patients (Arm B - after 2006) had their DPD status phenotypically evaluated prior to receiving 5-FU, with subsequent dose reducti

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Zhou, Heng, Cong Chen, Linda Sun, and Zhen Zeng. "A novel framework of Bayesian optimal interval design for phase I trials with late-onset toxicities." Contemporary Clinical Trials 105 (June 2021): 106404. http://dx.doi.org/10.1016/j.cct.2021.106404.

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Wang, W., Y. Zhang, Z. Gu, et al. "Daily Online Adaptive Radiotherapy for Rectal Cancer Utilizing CT-Linac: Assessing Feasibility, Toxicities and Optimal Margins." International Journal of Radiation Oncology*Biology*Physics 120, no. 2 (2024): e595-e596. http://dx.doi.org/10.1016/j.ijrobp.2024.07.1312.

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Xu, Zichun, and Xiaolei Lin. "Probability-of-decision interval 3+3 (POD-i3+3) design for phase I dose finding trials with late-onset toxicity." Statistical Methods in Medical Research 31, no. 3 (2021): 534–48. http://dx.doi.org/10.1177/09622802211052746.

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Late-onset toxicities often occur in phase I trials investigating novel immunotherapy and molecular targeted therapies. For trials with cohort based designs (such as modified toxicity probability interval, Bayesian optimal interval, and i3+3), patients are often turned away since the current cohort are still being followed without definite dose-limiting toxicities, which results in prolonged trial duration and waste of patient resources. In this paper, we incorporate a probability-of-decision framework into the i3+3 design and allow real-time dosing inference when the next patient becomes avai

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Mueller, Joerg P., Nils O'Brien, Franz Osl, et al. "Abstract 1876: ROCKETS Science: A novel processing toolbox for light sheet microscopy reveals unknown binding sites for EpCAM-targeted antibodies." Cancer Research 82, no. 12_Supplement (2022): 1876. http://dx.doi.org/10.1158/1538-7445.am2022-1876.

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Abstract Summary: We present a novel light sheet fluorescence microscopy (LSFM)-based imaging platform and corresponding set of procedures for greatly improved preclinical investigation of the biodistribution of novel drug candidates by the example of an EpCAM-targeting antibody. Methods: An anti-EpCAM antibody (G.8.8R) was applied intravenously to mice. Whole mice or individual organs were optically cleared following novel protocols, which we termed Rapid Optical Clearing Kit for Enhanced Tissue Scanning (ROCKETS). The procedures enabled processing of mouse organs and entire bodies for LSFM.

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Wu, Di, Wenlan Chen, Zhichao Chen, and Qiubai Li. "Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia." Case Reports in Hematology 2021 (January 12, 2021): 1–4. http://dx.doi.org/10.1155/2021/6661109.

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Mixed phenotype acute leukemia (MPAL) is a rare hematological malignancy that lacks consensus on optimal management. We report for the first time two cases of treatment-naïve B/myeloid MPAL patients treated with a novel chemo-free regimen using venetoclax combined with hypomethylating agents, which successfully induced complete remission with tolerable toxicities.

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Grunberg, Steven M. "Chemotherapy-Induced Nausea and Vomiting Incidence and Prevalence." American Society of Clinical Oncology Educational Book, no. 32 (June 2012): 541–43. http://dx.doi.org/10.14694/edbook_am.2012.32.45.

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Overview: Although chemotherapy-induced nausea and vomiting is recognized as having been an important problem during the initial introduction of chemotherapy into the antineoplastic armamentarium, the assumption that this problem has already been solved can restrict optimal management and further advances. Underestimation of nausea and vomiting may have many causes. If these toxicities are assumed to be necessary properties of chemotherapy, then their incidence may be taken for granted. If nausea and vomiting appear after discharge from the clinic several days after chemotherapy, these toxicit

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