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Journal articles on the topic 'Optical transduction techniques'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Bilaniuk, Nykolai. "Optical microphone transduction techniques." Applied Acoustics 50, no. 1 (1997): 35–63. http://dx.doi.org/10.1016/s0003-682x(96)00034-5.

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Yesilkoy, Filiz. "Optical Interrogation Techniques for Nanophotonic Biochemical Sensors." Sensors 19, no. 19 (2019): 4287. http://dx.doi.org/10.3390/s19194287.

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The manipulation of light via nanoengineered surfaces has excited the optical community in the past few decades. Among the many applications enabled by nanophotonic devices, sensing has stood out due to their capability of identifying miniscule refractive index changes. In particular, when free-space propagating light effectively couples into subwavelength volumes created by nanostructures, the strongly-localized near-fields can enhance light’s interaction with matter at the nanoscale. As a result, nanophotonic sensors can non-destructively detect chemical species in real-time without the need

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Bracamonte, Angel Guillermo. "Current Advances in Nanotechnology for the Next Generation of Sequencing (NGS)." Biosensors 13, no. 2 (2023): 260. http://dx.doi.org/10.3390/bios13020260.

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This communication aims at discussing strategies based on developments from nanotechnology focused on the next generation of sequencing (NGS). In this regard, it should be noted that even in the advanced current situation of many techniques and methods accompanied with developments of technology, there are still existing challenges and needs focused on real samples and low concentrations of genomic materials. The approaches discussed/described adopt spectroscopical techniques and new optical setups. PCR bases are introduced to understand the role of non-covalent interactions by discussing abou

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Du, Xiangying, and Xiaoming Yang. "In vivo imaging of vascular gene delivery/expression: Current status." Journal of X-Ray Science and Technology: Clinical Applications of Diagnosis and Therapeutics 11, no. 3 (2003): 125–32. http://dx.doi.org/10.3233/xst-2003-00084.

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Vascular gene therapy is a potential promising treatment for atherosclerotic disease. Imaging of vascular gene therapy is essential for the assessment of the success of the therapeutic strategy. Several imaging techniques, including MRI, ultrasound, and optical imaging, have been evaluated to monitor, enhance, and track vascular gene delivery, transfection/transduction, and expression. This review summarizes the current status of applying these techniques in the imaging of vascular gene therapy.

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Song, Xuehao, Min Han, Junchi Lai, and Hui Gao. "Optimization of coded modulation theory and algorithm for optical fiber communication incorporating biomechanical signal transduction mechanism." Molecular & Cellular Biomechanics 22, no. 4 (2025): 1564. https://doi.org/10.62617/mcb1564.

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Optical fiber communication coding and modulation techniques play a key role in high-speed and high-capacity transmission but are still limited by problems such as signal attenuation, nonlinear effects and increasing bit error rate. In order to optimize the performance of optical communication systems, this study draws on the biomechanical signal conduction mechanism to construct an optical fiber modulation scheme that integrates pulse time coding, adaptive modulation and redundancy coding. The experimental results show that this method significantly reduces the Bit Error Rate (BER), improves

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Hira, Steven M., Khaled Aledealat, Kan-Sheng Chen, et al. "Detection of Target ssDNA Using a Microfabricated Hall Magnetometer with Correlated Optical Readout." Journal of Biomedicine and Biotechnology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/492730.

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Sensing biological agents at the genomic level, while enhancing the response time for biodetection over commonly used, optics-based techniques such as nucleic acid microarrays or enzyme-linked immunosorbent assays (ELISAs), is an important criterion for new biosensors. Here, we describe the successful detection of a 35-base, single-strand nucleic acid target by Hall-based magnetic transduction as a mimic for pathogenic DNA target detection. The detection platform has low background, large signal amplification following target binding and can discriminate a single, 350 nm superparamagnetic bead

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López, Juana G., Mariana Muñoz, Valentina Arias, et al. "Electrochemical and Optical Carbon Dots and Glassy Carbon Biosensors: A Review on Their Development and Applications in Early Cancer Detection." Micromachines 16, no. 2 (2025): 139. https://doi.org/10.3390/mi16020139.

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Cancer remains one of the leading causes of mortality worldwide, making early detection a critical factor in improving patient outcomes and survival rates. Developing advanced biosensors is essential for achieving early detection and accurate cancer diagnosis. This review offers a comprehensive overview of the development and application of carbon dots (CDs) and glassy carbon (GC) biosensors for early cancer detection. It covers the synthesis of CDs and GC, electrode fabrication methods, and electrochemical and optical transduction principles. This review explores various biosensors, including

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8

MacDougall, Matthew, Samuel U. Nummela, Shanna Coop, Anita Disney, Jude F. Mitchell, and Cory T. Miller. "Optogenetic manipulation of neural circuits in awake marmosets." Journal of Neurophysiology 116, no. 3 (2016): 1286–94. http://dx.doi.org/10.1152/jn.00197.2016.

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Optogenetics has revolutionized the study of functional neuronal circuitry (Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Nat Neurosci 8: 1263–1268, 2005; Deisseroth K. Nat Methods 8: 26–29, 2011). Although these techniques have been most successfully implemented in rodent models, they have the potential to be similarly impactful in studies of nonhuman primate brains. Common marmosets ( Callithrix jacchus) have recently emerged as a candidate primate model for gene editing, providing a potentially powerful model for studies of neural circuitry and disease in primates. The application o

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Alves, Alanne, Kleilton Oliveira, Arthur Thamay, and Marcus Lia Fook. "ENZYMATIC UREA BIOSENSOR WITH OPTICAL TRANSDUCTION FOR RENAL DISEASE MONITORING USING CONVOLUTIONAL NEURAL NETWORK." Journal of Media Critiques 11, no. 27 (2025): e269. https://doi.org/10.17349/jmcv11n27-071.

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This study describes the development of an enzymatic biosensor for urea detection with optical transduction, designed to monitor Chronic Kidney Disease (CKD). CKD is a serious condition characterized by the progressive and irreversible loss of kidney function, compromising the body's ability to maintain homeostasis. The primary goal of the developed biosensor is to assist in the early diagnosis of CKD, which is essential for improving patient prognosis. The biosensor's production involved the immobilization of the urease enzyme on a polyvinylpyrrolidone film, using Nessler's reagent for optica

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Rittersma, Z. M. "Recent achievements in miniaturised humidity sensors—a review of transduction techniques." Sensors and Actuators A: Physical 96, no. 2-3 (2002): 196–210. http://dx.doi.org/10.1016/s0924-4247(01)00788-9.

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Tong, Ge, and Zhenchen Du. "Advances in bioimaging techniques for studying cellular mechanics." Molecular & Cellular Biomechanics 21, no. 3 (2024): 308. https://doi.org/10.62617/mcb308.

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Recent bioimaging advances have greatly aided cellular mechanics research. These advances have given researchers a new understanding of cell structure and function. Thus, these approaches have great optical coherence tomography (OCT) and temporal resolution, helping researchers understand previously inaccessible mechanical cell functions. The biggest drawback of all current techniques is their low resolutions, poor specificity, and inability to investigate cellular mechanics in complicated biological contexts in real-time. Introducing Cellular Mechanics using Bioimaging Techniques (CM-BT) will

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Tsien, R. Y. "Intracellular signal transduction in four dimensions: from molecular design to physiology." American Journal of Physiology-Cell Physiology 263, no. 4 (1992): C723—C728. http://dx.doi.org/10.1152/ajpcell.1992.263.4.c723.

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Designed fluorescent indicators are the basis for a major new technique in cell physiology, the quantitative measurement and dynamic imaging of intracellular concentrations of important ions and messengers such as Ca2+, Na+, H+, and adenosine 3',5'-cyclic monophosphate. Molecular engineering has now produced indicators with quite good selectivity and sensitivity for these analytes. In many cases, these probes can be introduced into large populations of cells by means of membrane-permeant chemical derivatives, so that the plasma membrane need never be disrupted or physically breached at any poi

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Tang, Jiukai, Guangyu Qiu, and Jing Wang. "Recent Development of Optofluidics for Imaging and Sensing Applications." Chemosensors 10, no. 1 (2022): 15. http://dx.doi.org/10.3390/chemosensors10010015.

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Optofluidics represents the interaction of light and fluids on a chip that integrates microfluidics and optics, which provides a promising optical platform for manipulating and analyzing fluid samples. Recent years have witnessed a substantial growth in optofluidic devices, including the integration of optical and fluidic control units, the incorporation of diverse photonic nanostructures, and new applications. All these advancements have enabled the implementation of optofluidics with improved performance. In this review, the recent advances of fabrication techniques and cutting-edge applicat

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Li, Xinrui, and Dandan Li. "Study of Wireless Sensor Network Based on Optical Communication: Research Challenges and Current Results." Modern Electronic Technology 6, no. 1 (2022): 33. http://dx.doi.org/10.26549/met.v6i1.11372.

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With the rapid developments of commercial demands, a majority of advanced researches have been investigated for the applications of underwater wireless sensor (WSN) networks. Recently optical communication has been considered for underwater wireless sensor network. An experimental set-up for testing optical communication underwater has been provided and designed in present papers to maximize the energy coupled from these displacements to the transduction mechanism that converts the mechanical energy into electrical. The true case has been considered by measuring diffuse attenuation coefficient

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Eghbali, Amir, Nikolay V. Pak, Aleksey V. Arsenin, Valentyn Volkov, and Andrey A. Vyshnevyy. "Photothermal Performance of 2D Material-Based Nanoparticles for Biomedical Applications." Nanomaterials 15, no. 12 (2025): 942. https://doi.org/10.3390/nano15120942.

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Photothermal therapy (PTT) is one of the rapidly developing methods for cancer treatment based on the strong light-to-heat conversion by nanoparticles. Over the past decade, the palette of photonic materials has expanded drastically, and nanoparticle fabrication techniques can now preserve the optical response of a bulk material in produced nanoparticles. This progress potentially holds opportunities for the efficiency enhancement of PTT, which have not fully explored yet. Here we study the photothermal performance of spherical nanoparticles (SNs) composed of novel two-dimensional (2D) and con

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Moore, Steven Ian, Michael G. Ruppert, and Yuen Kuan Yong. "Multimodal cantilevers with novel piezoelectric layer topology for sensitivity enhancement." Beilstein Journal of Nanotechnology 8 (February 6, 2017): 358–71. http://dx.doi.org/10.3762/bjnano.8.38.

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Self-sensing techniques for atomic force microscope (AFM) cantilevers have several advantageous characteristics compared to the optical beam deflection method. The possibility of down scaling, parallelization of cantilever arrays and the absence of optical interference associated imaging artifacts have led to an increased research interest in these methods. However, for multifrequency AFM, the optimization of the transducer layout on the cantilever for higher order modes has not been addressed. To fully utilize an integrated piezoelectric transducer, this work alters the layout of the piezoele

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El Kazzy, Marielle, Jonathan S. Weerakkody, Charlotte Hurot, et al. "An Overview of Artificial Olfaction Systems with a Focus on Surface Plasmon Resonance for the Analysis of Volatile Organic Compounds." Biosensors 11, no. 8 (2021): 244. http://dx.doi.org/10.3390/bios11080244.

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The last three decades have witnessed an increasing demand for novel analytical tools for the analysis of gases including odorants and volatile organic compounds (VOCs) in various domains. Traditional techniques such as gas chromatography coupled with mass spectrometry, although very efficient, present several drawbacks. Such a context has incited the research and industrial communities to work on the development of alternative technologies such as artificial olfaction systems, including gas sensors, olfactory biosensors and electronic noses (eNs). A wide variety of these systems have been des

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Bonini, Andrea, Angela Gilda Carota, Noemi Poma, et al. "Emerging Biosensing Technologies towards Early Sepsis Diagnosis and Management." Biosensors 12, no. 10 (2022): 894. http://dx.doi.org/10.3390/bios12100894.

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Sepsis is defined as a systemic inflammatory dysfunction strictly associated with infectious diseases, which represents an important health issue whose incidence is continuously increasing worldwide. Nowadays, sepsis is considered as one of the main causes of death that mainly affects critically ill patients in clinical settings, with a higher prevalence in low-income countries. Currently, sepsis management still represents an important challenge, since the use of traditional techniques for the diagnosis does not provide a rapid response, which is crucial for an effective infection management.

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Aziz, Ilaria Abdel, and Maria Rosa Antognazza. "Wireless nanotechnologies light up the next frontier in cell Calcium signalling." MRS Advances 5, no. 64 (2020): 3473–89. http://dx.doi.org/10.1557/adv.2020.348.

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AbstractCalcium ions impact nearly every aspect of cellular life, playing crucial roles as secondary messengers in regulation of neurotransmission, cell proliferation, migration and differentiation processes, intracellular homeostasis, long-distance signal propagation and stimuli physiological response. Despite its key-role, available techniques to study and selectively regulate Ca2+ signalling largely rely on chemical and electrical approaches, which often cannot ensure the necessary spatial and temporal resolution, specificity, modulation and reversal capability. In this context, Ca2+ modula

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Magazzù, Alessandro, and Carlos Marcuello. "Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review." Nanomaterials 13, no. 6 (2023): 963. http://dx.doi.org/10.3390/nano13060963.

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Soft matter exhibits a multitude of intrinsic physico-chemical attributes. Their mechanical properties are crucial characteristics to define their performance. In this context, the rigidity of these systems under exerted load forces is covered by the field of biomechanics. Moreover, cellular transduction processes which are involved in health and disease conditions are significantly affected by exogenous biomechanical actions. In this framework, atomic force microscopy (AFM) and optical tweezers (OT) can play an important role to determine the biomechanical parameters of the investigated syste

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Awang, Mohd Syafiq, Yazmin Bustami, Hairul Hisham Hamzah, et al. "Advancement in Salmonella Detection Methods: From Conventional to Electrochemical-Based Sensing Detection." Biosensors 11, no. 9 (2021): 346. http://dx.doi.org/10.3390/bios11090346.

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Large-scale food-borne outbreaks caused by Salmonella are rarely seen nowadays, thanks to the advanced nature of the medical system. However, small, localised outbreaks in certain regions still exist and could possess a huge threat to the public health if eradication measure is not initiated. This review discusses the progress of Salmonella detection approaches covering their basic principles, characteristics, applications, and performances. Conventional Salmonella detection is usually performed using a culture-based method, which is time-consuming, labour intensive, and unsuitable for on-site

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Cinelli, Angel R., Dalton Wang, Ping Chen, Weimin Liu, and Mimi Halpern. "Calcium Transients in the Garter Snake Vomeronasal Organ." Journal of Neurophysiology 87, no. 3 (2002): 1449–72. http://dx.doi.org/10.1152/jn.00651.2001.

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The signaling cascade involved in chemosensory transduction in the VN organ is incompletely understood. In snakes, the response to nonvolatile prey chemicals is mediated by the vomeronasal (VN) system. Using optical techniques and fluorescent Ca2+ indicators, we found that prey-derived chemoattractants produce initially a transient cytosolic accumulation of [Ca2+]i in the dendritic regions of VN neurons via two pathways: Ca2+release from IP3-sensitive intracellular stores and, to a lesser extent, Ca2+ influx through the plasma membrane. Both components seem to be dependent on IP3 production. C

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TAO Yuan-Xiao, FU Hang, HU Shu-Xin, LI Ming, and LU Ying. "Localized Illumination-Enhanced Coupling of Single-Molecule Fluorescence and Single-Channel Patch-Clamp in Live Cells." Acta Physica Sinica 74, no. 13 (2025): 0. https://doi.org/10.7498/aps.74.20250471.

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Channel proteins act as precise molecular regulators of transmembrane transport, a fundamental process essential for maintaining cellular homeostasis. These proteins dynamically modulate their functional states through conformational changes, forming the structural basis for complex physiological processes such as signal transduction and energy metabolism. Single-molecule fluorescence spectroscopy and single-channel patch-clamp electrophysiology represent two cornerstone techniques in modern biophysics: the former enables molecular-resolution analysis of structural dynamics, while the latter p

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Banakar, Morteza, Masoud Hamidi, Zohaib Khurshid, et al. "Electrochemical Biosensors for Pathogen Detection: An Updated Review." Biosensors 12, no. 11 (2022): 927. http://dx.doi.org/10.3390/bios12110927.

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Electrochemical biosensors are a family of biosensors that use an electrochemical transducer to perform their functions. In recent decades, many electrochemical biosensors have been created for pathogen detection. These biosensors for detecting infections have been comprehensively studied in terms of transduction elements, biorecognition components, and electrochemical methods. This review discusses the biorecognition components that may be used to identify pathogens. These include antibodies and aptamers. The integration of transducers and electrode changes in biosensor design is a major disc

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Ciobotaru, Iulia Corina, Daniela Oprea, Constantin Claudiu Ciobotaru, and Teodor Adrian Enache. "Low-Cost Plant-Based Metal and Metal Oxide Nanoparticle Synthesis and Their Use in Optical and Electrochemical (Bio)Sensors." Biosensors 13, no. 12 (2023): 1031. http://dx.doi.org/10.3390/bios13121031.

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Technological progress has led to the development of analytical tools that promise a huge socio-economic impact on our daily lives and an improved quality of life for all. The use of plant extract synthesized nanoparticles in the development and fabrication of optical or electrochemical (bio)sensors presents major advantages. Besides their low-cost fabrication and scalability, these nanoparticles may have a dual role, serving as a transducer component and as a recognition element, the latter requiring their functionalization with specific components. Different approaches, such as surface modif

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Wong, Elicia L. S., Khuong Q. Vuong, and Edith Chow. "Nanozymes for Environmental Pollutant Monitoring and Remediation." Sensors 21, no. 2 (2021): 408. http://dx.doi.org/10.3390/s21020408.

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Nanozymes are advanced nanomaterials which mimic natural enzymes by exhibiting enzyme-like properties. As nanozymes offer better structural stability over their respective natural enzymes, they are ideal candidates for real-time and/or remote environmental pollutant monitoring and remediation. In this review, we classify nanozymes into four types depending on their enzyme-mimicking behaviour (active metal centre mimic, functional mimic, nanocomposite or 3D structural mimic) and offer mechanistic insights into the nature of their catalytic activity. Following this, we discuss the current enviro

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Wong, Elicia L. S., Khuong Q. Vuong, and Edith Chow. "Nanozymes for Environmental Pollutant Monitoring and Remediation." Sensors 21, no. 2 (2021): 408. http://dx.doi.org/10.3390/s21020408.

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Nanozymes are advanced nanomaterials which mimic natural enzymes by exhibiting enzyme-like properties. As nanozymes offer better structural stability over their respective natural enzymes, they are ideal candidates for real-time and/or remote environmental pollutant monitoring and remediation. In this review, we classify nanozymes into four types depending on their enzyme-mimicking behaviour (active metal centre mimic, functional mimic, nanocomposite or 3D structural mimic) and offer mechanistic insights into the nature of their catalytic activity. Following this, we discuss the current enviro

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Gharib, Ghazaleh, İsmail Bütün, Zülâl Muganlı, et al. "Biomedical Applications of Microfluidic Devices: A Review." Biosensors 12, no. 11 (2022): 1023. http://dx.doi.org/10.3390/bios12111023.

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Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ mode

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Singh, Kshitij RB, Harshita Rai, Safalmani Pradhan, and Shyam S. Pandey. "Development of Sustainable Electronic Device for Non-Enzymatic Glucose Sensing through Extended-Gate-Based Organic Field Effect Transistors." ECS Meeting Abstracts MA2024-02, no. 64 (2024): 4316. https://doi.org/10.1149/ma2024-02644316mtgabs.

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Diabetes is one the most common problem and can lead to kidney failure and other deadly medical conditions if not monitored properly. The pre-existing techniques for monitoring diabetes utilize enzymes, which makes the technique costly, sophisticated, and temperature-dependent storage restricts its broad utilities and to circumvent this drawback of pre-existing techniques, label-free detection of glucose is highly desired. Thus, in this study, CuO/MXenes were synthesized by adopting an ex-situ synthesis approach. Initially, CuO nanoparticles were synthesized using Annona squamosa seed extract

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Aydin, Elif Burcu, Muhammet Aydin, and Mustafa Kemal Sezginturk. "Biosensors in Drug Discovery and Drug Analysis." Current Analytical Chemistry 15, no. 4 (2019): 467–84. http://dx.doi.org/10.2174/1573411014666180912131811.

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Background: The determination of drugs in pharmaceutical formulations and human biologic fluids is important for pharmaceutical and medical sciences. Successful analysis requires low sensitivity, high selectivity and minimum interference effects. Current analytical methods can detect drugs at very low levels but these methods require long sample preparation steps, extraction prior to analysis, highly trained technical staff and high-cost instruments. Biosensors offer several advantages such as short analysis time, high sensitivity, real-time analysis, low-cost instruments, and short pretreatme

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Inês, António, and Fernanda Cosme. "Biosensors for Detecting Food Contaminants—An Overview." Processes 13, no. 2 (2025): 380. https://doi.org/10.3390/pr13020380.

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Food safety is a pressing global concern due to the risks posed by contaminants such as pesticide residues, heavy metals, allergens, mycotoxins, and pathogenic microorganisms. While accurate, traditional detection methods like ELISA, HPLC, and mass spectrometry are often time-consuming and resource-intensive, highlighting the need for innovative alternatives. Biosensors based on biological recognition elements such as enzymes, antibodies, and aptamers, offer fast, sensitive, and cost-effective solutions. Using transduction mechanisms like electrochemical, optical, piezoelectric, and thermal sy

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Manciu, Felicia S., John D. Ciubuc, Karla Parra, et al. "Label-Free Raman Imaging to Monitor Breast Tumor Signatures." Technology in Cancer Research & Treatment 16, no. 4 (2016): 461–69. http://dx.doi.org/10.1177/1533034616655953.

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Although not yet ready for clinical application, methods based on Raman spectroscopy have shown significant potential in identifying, characterizing, and discriminating between noncancerous and cancerous specimens. Real-time and accurate medical diagnosis achievable through this vibrational optical method largely benefits from improvements in current technological and software capabilities. Not only is the acquisition of spectral information now possible in milliseconds and analysis of hundreds of thousands of data points achieved in minutes, but Raman spectroscopy also allows simultaneous det

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Gargiulo, Valentina, Michela Alfè, Laura Giordano, and Stefano Lettieri. "Materials for Chemical Sensing: A Comprehensive Review on the Recent Advances and Outlook Using Ionic Liquids, Metal–Organic Frameworks (MOFs), and MOF-Based Composites." Chemosensors 10, no. 8 (2022): 290. http://dx.doi.org/10.3390/chemosensors10080290.

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The ability to measure and monitor the concentration of specific chemical and/or gaseous species (i.e., “analytes”) is the main requirement in many fields, including industrial processes, medical applications, and workplace safety management. As a consequence, several kinds of sensors have been developed in the modern era according to some practical guidelines that regard the characteristics of the active (sensing) materials on which the sensor devices are based. These characteristics include the cost-effectiveness of the materials’ manufacturing, the sensitivity to analytes, the material stab

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Skorobogatiy, Maksim. "Microstructured and Photonic Bandgap Fibers for Applications in the Resonant Bio- and Chemical Sensors." Journal of Sensors 2009 (2009): 1–20. http://dx.doi.org/10.1155/2009/524237.

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We review application of microstructured and photonic bandgap fibers for designing resonant optical sensors of changes in the value of analyte refractive index. This research subject has recently invoked much attention due to development of novel fiber types, as well as due to development of techniques for the activation of fiber microstructure with functional materials. Particularly, we consider two sensors types. The first sensor type employs hollow core photonic bandgap fibers where core guided mode is confined in the analyte filled core through resonant effect in the surrounding periodic r

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Helbig, Klaus. "Fifty years of amplitude control." GEOPHYSICS 63, no. 2 (1998): 750–62. http://dx.doi.org/10.1190/1.1444375.

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The amplitudes of seismic waves have always been a foremost concern of the seismologist to which considerable ingenuity was devoted. In the 1920s the problem was to magnify the ground motion sufficiently for detection. This was done at first by simple levers that moved mechanical pens. But at the start of exploration seismology, this had already been superseded by optical levers, photographic recording, and (soon after) electromechanical transduction followed by amplification. From the 1930s to about the early ’60s, devices of increasing complexity were introduced to compress the large amplitu

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Song, Sang Ok, Anirikh Chakrabarti, and Jeffrey D. Varner. "Ensembles of signal transduction models using Pareto Optimal Ensemble Techniques (POETs)." Biotechnology Journal 5, no. 7 (2010): 768–80. http://dx.doi.org/10.1002/biot.201000059.

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Chappanda, Karumbaiah N., Mohamed R. Tchalala, Osama Shekhah, Sandeep G. Surya, Mohamed Eddaoudi, and Khaled N. Salama. "A Comparative Study of Interdigitated Electrode and Quartz Crystal Microbalance Transduction Techniques for Metal–Organic Framework-Based Acetone Sensors." Sensors 18, no. 11 (2018): 3898. http://dx.doi.org/10.3390/s18113898.

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We present a comparative study of two types of sensor with different transduction techniques but coated with the same sensing material to determine the effect of the transduction mechanism on the sensing performance of sensing a target analyte. For this purpose, interdigitated electrode (IDE)-based capacitors and quartz crystal microbalance (QCM)-based resonators were coated with a zeolitic–imidazolate framework (ZIF-8) metal–organic framework thin films as the sensing material and applied to the sensing of the volatile organic compound acetone. Cyclic immersion in methanolic precursor solutio

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Djohan, Risal S., Heron E. Rodriguez, Mark M. Connolly, Sara Jean Childers, Berton Braverman, and Francis J. Podbielski. "Intraoperative Monitoring of Recurrent Laryngeal Nerve Function." American Surgeon 66, no. 6 (2000): 595–97. http://dx.doi.org/10.1177/000313480006600614.

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Intraoperative recurrent laryngeal nerve identification is sometimes difficult in reoperative cervical dissection or operation for inflammatory thyroid disorders. Three modalities have been described to intraoperatively assess nerve function: vocal cord visualization with fiberoptic bronchoscopy or direct laryngoscopy, electromyelographic surveillance of arytenoid muscle function, and cord function assessment with an electromyelogram-electrode endotracheal tube. Our study focused on patients requiring cervical dissection for thyroid or parathyroid disease in which intraoperative recurrent lary

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Martinez, Emily M., Samuel D. Klebanoff, Stephanie Secrest, et al. "High-Throughput Flow Cytometric Method for the Simultaneous Measurement of CAR-T Cell Characterization and Cytotoxicity against Solid Tumor Cell Lines." SLAS DISCOVERY: Advancing the Science of Drug Discovery 23, no. 7 (2018): 603–12. http://dx.doi.org/10.1177/2472555218768745.

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High-throughput flow cytometry is an attractive platform for the analysis of adoptive cellular therapies such as chimeric antigen receptor T cell therapy (CAR-T) because it allows for the concurrent measurement of T cell–dependent cellular cytotoxicity (TDCC) and the functional characterization of engineered T cells with respect to percentage of CAR transduction, T cell phenotype, and measurement of T cell function such as activation in a single assay. The use of adherent tumor cell lines can be challenging in these flow-based assays. Here, we present the development of a high-throughput flow-

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Olsen, Zakai J., and Kwang J. Kim. "Characterizing the transduction behavior of ionic polymer-metal composite actuators and sensors via dimensional analysis." Smart Materials and Structures 31, no. 2 (2021): 025014. http://dx.doi.org/10.1088/1361-665x/ac411e.

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Abstract Ionic polymer-metal composites (IPMCs) are functional smart materials that exhibit both electromechanical and mechanoelectrical transduction properties, and the physical phenomenon underlying the transduction mechanisms have been studied across the literature extensively. Here we use a new modeling framework to conduct the most comprehensive dimensional analysis of IPMC transduction phenomena, characterizing the IPMC actuator displacement, actuator blocking force, short-circuit sensing current, and open-circuit sensing voltage under static and dynamic loading. The information obtained

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Morigaki, Kenichi. "(Invited) Integrated Model System of the Biological Membrane on Solid Surface." ECS Meeting Abstracts MA2024-02, no. 68 (2024): 4811. https://doi.org/10.1149/ma2024-02684811mtgabs.

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The biological membrane comprising lipid bilayer membrane and membrane-associated proteins performs a wide range of cellular functions, including signal transduction and energy conversion. Diseases such as cancer and COVID-19 are mechanistically linked with the biological membrane. An important structural feature of the biological membrane is the combination of two-dimensional (2D) and three-dimensional (3D) architectures that form organized 2D fluid and create compartments in the cell and cell-cell junctions. The dynamic self-assembly of the 2D/ 3D membrane structures and their cooperative fu

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Kitte, Reni, Robert Serfling, Ulrich Blache, et al. "Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell Generation." International Journal of Molecular Sciences 26, no. 3 (2025): 965. https://doi.org/10.3390/ijms26030965.

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Genetically modified T lymphocytes expressing chimeric antigen receptors (CARs) are becoming increasingly important in the treatment of hematologic malignancies and are also intensively being investigated for other diseases such as autoimmune disorders and HIV. Current CAR T cell therapies predominantly use viral transduction methods which, despite their efficacy, raise safety concerns related to genomic integration and potentially associated malignancies as well as labor- and cost-intensive manufacturing. Therefore, non-viral gene transfer methods, especially mRNA-based approaches, have attra

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Niu, Ting, Amer M. Najjar, Simon N. Robinson, et al. "Retroviral Gene Transfer with Triple Genetic Reporter Genes into Human Cord Blood CD133+ Cells." Blood 104, no. 11 (2004): 5260. http://dx.doi.org/10.1182/blood.v104.11.5260.5260.

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Abstract Umbilical cord blood (CB) is used increasingly as a source of hematopoietic support in bone marrow transplant patients lacking family or unrelated donors. Little is known about human CB with respect to in vivo migration, homing, long-term viability, the organ-specific checkpoints and its differentiation. In order to study CB migration and homing, the gibbon ape leukemia virus (GALV)-pseudotyped retroviral gene transfer technique was developed to genetically modify CB CD133+ cells with triple reporter genes which encode enhanced green fluorescent protein (eGFP), luciferase, and herpes

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El-Sharoud, Walid M. "Two-Component Signal Transduction Systems as Key Players in Stress responses of Lactic Acid Bacteria." Science Progress 88, no. 4 (2005): 203–28. http://dx.doi.org/10.3184/003685005783238381.

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Lactic acid bacteria (LAB) continue as an important group of gram-positive bacteria that have been extensively exploited in food industries and various biotechnological applications. Some LAB species are, however, opportunistic pathogens and were reported to be associated with overwhelming number of human infections. During the use of LAB in industry or over the course of human infection, these bacteria are exposed to environmental stress. While LAB display adaptive mechanisms to cope with adverse conditions, the regulation of these mechanisms remains to be elucidated. Recent completion of gen

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dos Santos, Andreia, Elvira Fortunato, Rodrigo Martins, Hugo Águas, and Rui Igreja. "Transduction Mechanisms, Micro-Structuring Techniques, and Applications of Electronic Skin Pressure Sensors: A Review of Recent Advances." Sensors 20, no. 16 (2020): 4407. http://dx.doi.org/10.3390/s20164407.

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Electronic skin (e-skin), which is an electronic surrogate of human skin, aims to recreate the multifunctionality of skin by using sensing units to detect multiple stimuli, while keeping key features of skin such as low thickness, stretchability, flexibility, and conformability. One of the most important stimuli to be detected is pressure due to its relevance in a plethora of applications, from health monitoring to functional prosthesis, robotics, and human-machine-interfaces (HMI). The performance of these e-skin pressure sensors is tailored, typically through micro-structuring techniques (su

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Cerimovic, Samir, Albert Treytl, Thomas Glatzl, Roman Beigelbeck, Franz Keplinger, and Thilo Sauter. "Development and Characterization of Thermal Flow Sensors for Non-Invasive Measurements in HVAC Systems." Sensors 19, no. 6 (2019): 1397. http://dx.doi.org/10.3390/s19061397.

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We investigated non-invasive flow rate measurements in heating, ventilation, and air conditioning (HVAC) systems utilizing thermal transduction instead of commonly used ultrasonic techniques. The proposed thermal flow transduction comprises two temperature sensors and a heater, all mounted non-invasively on the outer surface of metal-pipes and, therefore, not disturbing the fluid flow inside. One temperature sensor measures the heater temperature, whereas the other one, mounted upstream of the heater, follows the fluid temperature for reference. The temperature difference (i.e., the heater exc

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Santiago Júnior, Valdivino Alexandre de. "Empirical Evidence Regarding Few-Shot Learning for Scene Classification in Remote Sensing Images." Applied Sciences 14, no. 23 (2024): 10776. http://dx.doi.org/10.3390/app142310776.

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Few-shot learning (FSL) is a learning paradigm which aims to address the issue of machine/deep learning techniques which traditionally need huge amounts of labelled data to work out. The remote sensing (RS) community has explored this paradigm with numerous published studies to date. Nevertheless, there is still a need for clear pieces of evidence on FSL-related issues in the RS context, such as which of the inference approaches is more suitable: inductive or transductive? Moreover, how does the number of epochs used during training, based on the meta-training (base) dataset, relate to the num

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Niu, Ting, Amer M. Najjar, Simon N. Robinson, et al. "High Efficiency Transduction of Human Mesenchymal Stem Cells Using Retroviral Gene Transfer with Triple Reporter Genes." Blood 104, no. 11 (2004): 4258. http://dx.doi.org/10.1182/blood.v104.11.4258.4258.

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Abstract Cotransplantation of ex vivo-expanded mesenchymal stem cells (MSC) together with hematopoietic stem cells hastens hematopoietic recovery in animal models and potentially humans. The in vivo mechanisms of migration, homing and long-term viability of MSC following implantation are not well understood. Reporter gene labeling would permit the tracking of transplanted MSC in vivo through noninvasive imaging techniques, namely fluorescence, bioluminescence, and nuclear imaging. Accordingly, a gibbon ape leukemia virus (GALV)-pseudotyped retrovirus was utilized to transfer a triple fusion ge

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Rocca, Andrea, and Boris N. Kholodenko. "Can Systems Biology Advance Clinical Precision Oncology?" Cancers 13, no. 24 (2021): 6312. http://dx.doi.org/10.3390/cancers13246312.

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Precision oncology is perceived as a way forward to treat individual cancer patients. However, knowing particular cancer mutations is not enough for optimal therapeutic treatment, because cancer genotype-phenotype relationships are nonlinear and dynamic. Systems biology studies the biological processes at the systems’ level, using an array of techniques, ranging from statistical methods to network reconstruction and analysis, to mathematical modeling. Its goal is to reconstruct the complex and often counterintuitive dynamic behavior of biological systems and quantitatively predict their respon

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Pesavento, Maria, Simone Marchetti, Letizia De Maria, Luigi Zeni, and Nunzio Cennamo. "Sensing by Molecularly Imprinted Polymer: Evaluation of the Binding Properties with Different Techniques." Sensors 19, no. 6 (2019): 1344. http://dx.doi.org/10.3390/s19061344.

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The possibility of investigating the binding properties of the same molecularly imprinted polymer (MIP), most probably heterogeneous, at various concentration levels by different methods such as batch equilibration and sensing, is examined, considering two kinds of sensors, based respectively on electrochemical and surface plasmon resonance (SPR) transduction. As a proof of principle, the considered MIP was obtained by non-covalent molecular imprinting of 2-furaldehyde (2-FAL). It has been found that different concentration ranges of 2-FAL in aqueous matrices can be measured by the two sensing

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