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Journal articles on the topic 'Optimal benefits and burdens'

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1

Shaha, Steven H., Kelly F. Glassett, David Rosenlund, Aimee Copas, and T. Lisa Huddleston. "From Burdens To Benefits: The Societal Impact Of PDL-Enriched, Efficacy-Enhanced Educators." Journal of International Education Research (JIER) 12, no. 2 (2016): 77–86. http://dx.doi.org/10.19030/jier.v12i2.9630.

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Societies continue to absorb increased burdens in cost for helping citizens unable to achieve at optimal levels. Building on past research, we project educational benefits to offset current societal burdens through enhanced educator capabilities. Studies reviewed show participation in a high-impact professional development and learning solution resulted in improved student performance and reduced dropout rates, reduced disciplinary rates and increased rates for college-bound, along with lower teacher turnover. Computations show that generalization of such impacts should trade societal burdens
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Ouellet, Gregory M., Jennifer A. Ouellet, and Mary E. Tinetti. "Principle of rational prescribing and deprescribing in older adults with multiple chronic conditions." Therapeutic Advances in Drug Safety 9, no. 11 (2018): 639–52. http://dx.doi.org/10.1177/2042098618791371.

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Although the majority of older adults in the developed world live with multiple chronic conditions (MCCs), the task of selecting optimal treatment regimens is still fraught with difficulty. Older adults with MCCs may derive less benefit from prescribed medications than healthier patients as a result of the competing risk of several possible outcomes including, but not limited to, death before a benefit can be accrued. In addition, these patients may be at increased risk of medication-related harms in the form of adverse effects and significant burdens of treatment. At present, the balance of t
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McLaren, Rodney A., Fouad Atallah, and Howard Minkoff. "Antibiotic Prophylaxis Trials in Obstetrics: A Call for Pediatric Collaboration." American Journal of Perinatology Reports 10, no. 02 (2020): e155-e158. http://dx.doi.org/10.1055/s-0040-1709513.

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AbstractSurgical site infections are common complications of cesarean delivery. Many recent studies, including meta-analyses, have assessed the efficacy of antibiotic prophylaxis. Those articles have demonstrated that preincision antibiotic prophylaxis reduces the incidence of surgical site infections postcesarean, and that the use of adjunctive azithromycin further reduces infection after nonelective cesarean deliveries. However, long-term effects of fetal exposure to antibiotic prophylaxis—including asthma, obesity, and alterations in microbiota—have also been demonstrated. We suggest that w
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Bachurin, Dmitriy G. "Methodological solutions for the shaping of the theoretical and legal foundations of the state policy in the area of VAT taxation." Bulletin of the Far Eastern Federal University. Economics and Management, no. 2(82)2017 (August 4, 2017): 3–14. https://doi.org/10.5281/zenodo.819521.

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<em>The article presents the hypothesis paradigm shift of modern taxation by extending the domain of research and the use of economic and legal methodology in conjunction with the elements of the historical approach. As a methodological device for the development and decision-making in the field of value added tax proposed the principle of proportionality optimal benefits and burdens. In the final part conclusions about the possibilities of increasing the effectiveness of research in the area of improving the fiscal and regulatory capabilities of value added tax based on the integrated applica
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Cooper, James, and Bruce Kobayashi. "Unreasonable: A Strict Liability Solution to the FTC’s Data Security Problem." Michigan Technology Law Review, no. 28.2 (2022): 257. http://dx.doi.org/10.36645/mtlr.28.2.unreasonable.

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For over two decades, the FTC creatively employed its capacious statute to police against shoddy data practices. Although the FTC’s actions were arguably needed at the time to fill a gap in enforcement, there are reasons to believe that its current approach has outlived its usefulness and is in serious need of updating. In particular, our analysis shows that the FTC’s current approach to data security is unlikely to instill anything close to optimal incentives for data holders. These shortcomings cannot be fixed through changes to the FTC enforcement approach, as they are largely generated by
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Nugent, Diane, and W. Keith Hoots. "Evidence for the benefits of prophylaxis in the management of hemophilia A." Thrombosis and Haemostasis 96, no. 10 (2006): 433–40. http://dx.doi.org/10.1160/th06-02-0125.

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SummaryThe optimal treatment of hemophilia has been evolving since the advent of factor VIII concentrates, continues to vary geographically, and remains a source of debate. There now exists an extensive clinical literature that demonstrates clear benefits of prophylaxis for patients with hemophilia A compared to on-demand treatment, including a reduction in the number of bleeding episodes, improved joint function, and greater patient well-being. However, the value of these benefits must be weighed against the heavier economic burden of increased factor use. This paper reviews the literature th
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Voinea, Cristina Maria. "Optimal Employment Formula – Accounting and Tax Approach." Valahian Journal of Economic Studies 8, no. 2 (2017): 57–64. http://dx.doi.org/10.1515/vjes-2017-0019.

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Abstract Human resource is the most important investment level economic entity and it is the only able to increase its value over time. The burden of managing human factors is quite high. Both employers and employees are seeking optimal solutions on the type of employment that will bring the greatest benefits.
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Cenin, Dayna, Pei Li, Jie Wang, et al. "Optimising colorectal cancer screening in Shanghai, China: a modelling study." BMJ Open 12, no. 5 (2022): e048156. http://dx.doi.org/10.1136/bmjopen-2020-048156.

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IntroductionTo reduce the burden of colorectal cancer (CRC) in Shanghai, China, a CRC screening programme was commenced in 2013 inviting those aged 50–74 years to triennial screening with a faecal immunochemical test (FIT) and risk assessment. However, it is unknown whether this is the optimal screening strategy for this population. We aimed to determine the optimal CRC screening programme for Shanghai in terms of benefits, burden, harms and cost-effectiveness.MethodsUsing Microsimulation Screening Analysis-Colon (MISCAN-Colon), we estimated the costs and effects of the current screening progr
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Mi, Michael Y., Andrew S. Perry, Vaishnavi Krishnan, and Matthew Nayor. "Epidemiology and Cardiovascular Benefits of Physical Activity and Exercise." Circulation Research 137, no. 2 (2025): 120–38. https://doi.org/10.1161/circresaha.125.325526.

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While humans evolved to perform routine endurance activity, recent secular trends in the United States and globally have resulted in a dramatic rise in the amount of time spent inactive in both occupational and leisure-time settings. The high burden of physical inactivity is responsible for a high risk of preventable noncommunicable disease including cardiovascular disease, cancer, and premature death. In this review, we focus on the beneficial effects of routine physical activity (PA) on the cardiovascular system, the different ways we can achieve and measure PA, and the evidence supporting k
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He, Ping, Guang Fu Liu, and Dan Zhou. "A Decision-Making Model of Energy-Saving Design and a Case Study." Applied Mechanics and Materials 130-134 (October 2011): 1586–89. http://dx.doi.org/10.4028/www.scientific.net/amm.130-134.1586.

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Pursuing the green design (GD) of products is highly beneficial in the alleviation of environment burdens. In order to gain such benefits, GD is involved in entire product lifecycle. During the product lifecycle, energy-saving is one of the main roots of environmental pollution, with the optimal calculation of the total energy consumption for GD being an important path to reduce the environmental pollution. The objective factors of decision-making problems in the traditional product design are usually three: life、quality and cost; but from the viewpoint of GD, energy consumption should also be
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11

Samiun, Muh. Amir, and Dwi Putranto Riau. "STRATEGI BADAN PENDAPATAN DAERAH KABUPATEN BUTON TENGAH DALAM UPAYA PENINGKATAN PENDAPATAN DAERAH." Journal Publicuho 7, no. 4 (2024): 2199–208. https://doi.org/10.35817/publicuho.v7i4.581.

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This study aims to analyze the Regional Revenue Agency (BAPENDA) planning strategies of Buton Tengah Regency in increasing regional income. Using a qualitative approach, the study involved 20 respondents selected through a PSS (5:1) mechanism and 5 informants chosen purposively. Data collection was conducted through a series of in-depth interviews to evaluate organizational performance based on five key dimensions: productive efficiency, service standards, responsiveness, compliance level, and management transparency. Data analysis employed the interactive approach developed by Milles and Hube
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Yulianti, Evi, Indah Pratiwi Putri, and Dona Marcelina. "A Prognostic System for Pharmaceutical Inventory Forecasting Using the Trend Least Squares Method at Rakha Medika." Acceleration, Quantum, Information Technology and Algorithm Journal 2, no. 1 (2025): 28–37. https://doi.org/10.62123/aqila.v2i1.80.

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This study proposes the development of a sophisticated predictive system for pharmaceutical inventory management at Rakha Medika, Palembang, aimed at addressing the prevalent challenges associated with inaccurate drug stock forecasting. Employing the Trend Least Squares method, the system leverages historical consumption data to generate precise predictions of future pharmaceutical needs, thereby facilitating optimal procurement strategies and mitigating the risks of both stockouts and surplus inventory. Developed with PHP and MySQL, the system offers a user-friendly web-based interface, provi
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Dahiru, Ahmed Tijjani, Tan Chee Wei, Habibu Guda Rano, Mustapha Sani Sumaila, Adamu Abdullahi Maidallah, and Chukwunwike Emmanuel Attamah. "A Comparative Analysis of Optimization Techniques Used in the Sizing of a Residential Nanogrid." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 127, no. 2 (2025): 106–18. https://doi.org/10.37934/arfmts.127.2.106118.

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Economic use of resources and technologies is mainly achieved using optimization frameworks. Optimizations for renewable energy system planning and operations are mainly implemented using either or combination of classical, intelligent-based, or off-the-shelf software techniques (tools). Each of the homogenous technique implementations exhibits a form or more of its opportunities and limitations. Classical techniques are opaque and loaded with computational burdens, however, they tend to be fast in achieving global solutions without branching at local solutions. The intelligent-based technique
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Bos, Frits, Thomas van der Pol, and Gerbert Romijn. "Should Benefit-Cost Analysis Include a Correction for the Marginal Excess Burden of Taxation?" Journal of Benefit-Cost Analysis 10, no. 3 (2019): 379–403. http://dx.doi.org/10.1017/bca.2019.11.

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AbstractThis paper provides an overview of theoretical, empirical, and practical arguments in favor of or against a correction for the marginal excess burden of taxation (MEB). Benefit-cost analysis (BCA) should be used to compare the costs and benefits of a policy measure and its major alternatives, and whenever relevant, also to compare different ways of financing this. The best pragmatic approach is then to assume first that a policy measure is financed out of general tax revenues and then that the MEB of these taxes is broadly counterbalanced by the benefits of redistribution of these taxe
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Iravani Saadi, Mahdiyar, Mani Ramzi, Nastaran Fooladivanda, et al. "Probiotics: Potential Benefits and Safety in Hematological Malignancies." Galen Medical Journal 13 (January 21, 2024): e3149. http://dx.doi.org/10.31661/gmj.v13i.3149.

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Cancer remains one of the most significant global health challenges, with increasing incidence and mortality rates and a substantial socioeconomic burden. Traditional cancer treatments such as chemotherapeutic drugs and radiation therapies, while effective, have significant adverse effects on the body, prompting the search for less invasive treatment options. In recent years, probiotics have emerged as a promising alternative in the prevention and treatment of cancer and its associated complications, especially in gastrointestinal malignancies. Probiotics have been found to have several benefi
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Aleid, Abdulsalam Mohammed, Ghadah Almutairi, Rudhab Alrizqi, et al. "The Impact of Statins on Disease Severity and Quality of Life in Patients with Psoriasis: A Systematic Review and Meta-Analysis." Healthcare 12, no. 15 (2024): 1526. http://dx.doi.org/10.3390/healthcare12151526.

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Background: Psoriasis, a chronic autoimmune condition, imposes significant burdens on patients’ well-being. While corticosteroid medications are commonly used, their prolonged use presents risks. Statins, known for their immunoregulatory and anti-inflammatory properties, have emerged as potential alternatives. Previous reviews indicated that statins might improve psoriasis symptoms but showed inconsistent results and lacked meta-analyses that generated pooled effect estimates. Therefore, this study addresses this gap by providing a comprehensive overview of the impact of statins on psoriasis s
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17

Franzoni, Luigi Alberto. "Legal Change in the Face of Risk-Averse Subjects: A Generalization of the Theory." American Law and Economics Review 21, no. 2 (2019): 394–430. http://dx.doi.org/10.1093/aler/ahz009.

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Abstract This study investigates the optimal nature of lawmaking under uncertainty. I focus on a case in which a harmful activity will be subjected to some regulatory measures (a standard, exposure to liability, or a corrective tax). The benefits and costs of precaution are ex ante uncertain, and this places a risk burden on both injurers and victims. The optimal policy should, at the same time, strike a balance between benefits and costs of the measures, and attenuate the ex ante risk. Whether measures should be made stronger or softer depends on the size and the sign of the shocks affecting
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18

Shin, Jeehoon, and Hyuk Lee. "Optimal Usability Test Procedure Generation for Medical Devices." Healthcare 11, no. 3 (2023): 296. http://dx.doi.org/10.3390/healthcare11030296.

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Medical device usability testing offers many benefits, including finding medical device usage errors and providing safety to users. As usability testing becomes mandatory for medical devices, manufacturers are increasing the cost burden. In order to perform a high-quality usability test, it is important to implement a usability test procedure, but guidelines for this are lacking. In this paper, we propose a method to systematically design and implement a usability test procedure. We propose methods to reduce test time-costs and apply them to implement the final procedure. Next, by applying the
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19

Jiang, Yang, Wei Zhang, Shihao Huang, et al. "Preoperative Prediction of New Vertebral Fractures after Vertebral Augmentation with a Radiomics Nomogram." Diagnostics 13, no. 22 (2023): 3459. http://dx.doi.org/10.3390/diagnostics13223459.

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The occurrence of new vertebral fractures (NVFs) after vertebral augmentation (VA) procedures is common in patients with osteoporotic vertebral compression fractures (OVCFs), leading to painful experiences and financial burdens. We aim to develop a radiomics nomogram for the preoperative prediction of NVFs after VA. Data from center 1 (training set: n = 153; internal validation set: n = 66) and center 2 (external validation set: n = 44) were retrospectively collected. Radiomics features were extracted from MRI images and radiomics scores (radscores) were constructed for each level-specific ver
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20

Palianychko, N., and V. Hrom. "Agricultural manufacturers taxation in the context of food security: environmental and economic aspects." Agroecological journal, no. 2 (May 24, 2024): 24–32. http://dx.doi.org/10.33730/2077-4893.2.2024.305650.

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The article examines the state, problems and prospects of taxation of agricultural producers. An analysis of the structural elements of the tax policy was carried out. The tax burden is calculated in relation to net profit, the area of agricultural land and arable land. The shortcomings of special regimes of taxation of domestic agricultural enterprises are identified. Directions for improving the mechanism of taxation of agricultural producers have been developed. The functioning of agricultural producers should provide for various state supports in the fiscal sphere, including the provision
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Hauber, Brett, Brennan Mange, Mo Zhou, et al. "Parkinson’s Patients’ Tolerance for Risk and Willingness to Wait for Potential Benefits of Novel Neurostimulation Devices: A Patient-Centered Threshold Technique Study." MDM Policy & Practice 6, no. 1 (2021): 238146832097840. http://dx.doi.org/10.1177/2381468320978407.

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Background. Parkinson’s disease (PD) is neurodegenerative, causing motor, cognitive, psychological, somatic, and autonomic symptoms. Understanding PD patients’ preferences for novel neurostimulation devices may help ensure that devices are delivered in a timely manner with the appropriate level of evidence. Our objective was to elicit preferences and willingness-to-wait for novel neurostimulation devices among PD patients to inform a model of optimal trial design. Methods. We developed and administered a survey to PD patients to quantify the maximum levels of risks that patients would accept t
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Byshovets, Y. P. "Use of tax benefits to optimize taxation." Uzhhorod National University Herald. Series: Law 2, no. 85 (2024): 230–40. http://dx.doi.org/10.24144/2307-3322.2024.85.2.34.

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Based on the analysis of current legislation, available scientific, journalistic and methodological sources, the article reveals the specifics of using tax benefits with a view to optimizing taxation. It is established that among the legal methods of tax optimization, the key ones are as follows: selection of the most optimal taxation system for doing business, which should be carefully analyzed taking into account the specifics of the business entity’s activities, its scale and structure; building a business model with integration of individual entrepreneurs under the simplified taxation syst
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Fernando, Vimukthi, Weena Lokuge, Hannah Seligmann, Hao Wang, and Chamila Gunasekara. "Sustainable Mortar with Waste Glass and Fly Ash: Impact of Glass Aggregate Size and Life-Cycle Assessment." Recycling 10, no. 4 (2025): 133. https://doi.org/10.3390/recycling10040133.

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This study investigates the use of Glass Fine Aggregate (GFA) and Fly Ash (FA) in mortar for Alkali–Silica Reaction (ASR) mitigation through a multidimensional evaluation. GFA was used to replace river sand in 20% increments up to 100%, while FA replaced cement at 10%, 20%, and 30%. Three GFA size ranges were considered: &lt;1.18 mm, 1.18–4.75 mm, and a combined fraction of &lt;4.75 mm. At 100% replacement, &lt;1.18 mm GFA reduced ASR expansion to 0.07%, compared to 0.2% for &lt;4.75 mm and 0.46% for 1.18–4.75 mm GFA. It also improved long-term strength by 25% from 28 days to 6 months due to p
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Yadav, Rajiv, Venus Chauhan, and Aman Jangra. "Comparative Analysis of Herbal and Allopathic Treatments in Diabetes Management: A Literature-Based Study." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 1784–89. https://doi.org/10.35629/4494-100317841789.

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Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from defects in insulin secretion, insulin action, or both. With the global prevalence of diabetes rising at an alarming rate, there is an increasing need for effective, accessible, and sustainable treatment strategies. This literature-based comparative study evaluates the strengths and limitations of both allopathic (conventional) and herbal (traditional) approaches in diabetes management. Allopathic medications, including metformin, sulfonylureas, and insulin analogs, offer rapid glycemic co
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Kermani, Maziar, Ivan D. Kantor, and François Maréchal. "Optimal Design of Heat-Integrated Water Allocation Networks." Energies 12, no. 11 (2019): 2174. http://dx.doi.org/10.3390/en12112174.

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Industrial operations consume energy and water in large quantities without accounting for potential economic and environmental burdens on future generations. Consumption of energy (mainly in the form of high pressure steam) and water (in the form of process water and cooling water) are essential to all processes and are strongly correlated, which requires development of systematic methodologies to address their interconnectivity. To this end, the subject of heat-integrated water allocation network design has received considerable attention within the research community in recent decades while
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Аблезова, Е. А., А. А. Огибенина, М. А. Собенин та М. В. Калинская. "Налоговые льготы и их эффективное использование". Innovative economy: information, analytics, forecasts, № 4 (11 червня 2025): 80–85. https://doi.org/10.47576/2949-1894.2025.4.4.010.

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В исследование рассматриваются актуальные возможности снижения налоговой нагрузки за счет грамотного использования предусмотренных законодательством льгот. Систематизированы основные виды налоговых преференций для бизнеса, включая федеральные и региональные льготы, специальные налоговые режимы, а также отраслевые налоговые преимущества. Особое внимание уделено практическим аспектам применения налоговых льгот: критериям выбора оптимальных преференций, типичным ошибкам при их оформлении и способам минимизации налоговых рисков. The study examines the current possibilities of reducing the tax burd
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Аблезова, Е. А., А. А. Огибенина, М. А. Собенин та М. В. Калинская. "Налоговые льготы и их эффективное использование". Innovative economy: information, analytics, forecasts, № 4 (11 червня 2025): 86–92. https://doi.org/10.47576/2949-1894.2025.4.4.011.

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В исследование рассматриваются актуальные возможности снижения налоговой нагрузки за счет грамотного использования предусмотренных законодательством льгот. Систематизированы основные виды налоговых преференций для бизнеса, включая федеральные и региональные льготы, специальные налоговые режимы, а также отраслевые налоговые преимущества. Особое внимание уделено практическим аспектам применения налоговых льгот: критериям выбора оптимальных преференций, типичным ошибкам при их оформлении и способам минимизации налоговых рисков. The study examines the current possibilities of reducing the tax burd
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Griffin, Jan M., and Jason N. Katz. "The Burden of Ventricular Arrhythmias Following Left Ventricular Assist Device Implantation." Arrhythmia & Electrophysiology Review 3, no. 3 (2014): 145. http://dx.doi.org/10.15420/aer.2014.3.3.145.

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Few innovations in medicine have so convincingly and expeditiously improved patient outcomes more than the development of the left ventricular assist device (LVAD). Where optimal pharmacotherapy once routinely failed those with end-stage disease, the LVAD now offers considerable hope for the growing advanced heart failure population. Despite improvements in mortality, however, mechanical circulatory support is not without its limitations. Those supported with an LVAD are at increased risk of several complications, including infection, bleeding, stroke and arrhythmic events. While once consider
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Heffernan, Alastair, Yanling Ma, Shevanthi Nayagam, et al. "Economic and epidemiological evaluation of interventions to reduce the burden of hepatitis C in Yunnan province, China." PLOS ONE 16, no. 1 (2021): e0245288. http://dx.doi.org/10.1371/journal.pone.0245288.

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Background The paradigm shift in hepatitis C virus (HCV) treatment options in the last five years has raised the prospect of eliminating the disease as a global health threat. This will require a step-change in the number being treated with the new direct-acting antivirals (DAAs). Given constrained budgets and competing priorities, policy makers need information on how to scale-up access to HCV treatment. To inform such decisions, we examined the cost effectiveness of screening and treatment interventions in Yunnan, China. Methods and findings We simulated the HCV epidemic using a previously p
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Armitage, Andrew E., and Diego Moretti. "The Importance of Iron Status for Young Children in Low- and Middle-Income Countries: A Narrative Review." Pharmaceuticals 12, no. 2 (2019): 59. http://dx.doi.org/10.3390/ph12020059.

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Early childhood is characterised by high physiological iron demand to support processes including blood volume expansion, brain development and tissue growth. Iron is also required for other essential functions including the generation of effective immune responses. Adequate iron status is therefore a prerequisite for optimal child development, yet nutritional iron deficiency and inflammation-related iron restriction are widespread amongst young children in low- and middle-income countries (LMICs), meaning iron demands are frequently not met. Consequently, therapeutic iron interventions are co
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Alcántara-Aragón, Valeria. "Improving patient self-care using diabetes technologies." Therapeutic Advances in Endocrinology and Metabolism 10 (January 2019): 204201881882421. http://dx.doi.org/10.1177/2042018818824215.

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Diabetes technologies are an unstoppable phenomenon. They offer opportunities to improve patient self-care through empowerment. However, they can be a challenge for both patients and clinicians. Thus, the use of technology may empower or burden. To understand and benefit from the use of diabetes technologies, one must understand the currently unmet needs in diabetes management. These unmet needs call for perspectives beyond glycated hemoglobin and an evaluation of technology solutions. Optimal use of these technologies is necessary to obtain benefits and achieve cost-effectiveness; this proces
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Fast, Richard. "Examining A Lump Sum Tax and Optimal Tax Theory." SocioEconomic Challenges 5, no. 4 (2021): 166–71. http://dx.doi.org/10.21272/sec.5(4).166-171.2021.

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This paper will cover an overview of Optimal Tax Theory with a special emphasis on the benefits and drawbacks of a Lump Sum Tax. Covering the work of Ramsey (1927), Mirrlees and Diamond (1971a, b), Slemrod and Yitzhaki (1996), Samuelson (1954), Lindahl (1919, 1958) and others, the paper compares and contrasts the foundational works in Optimal Tax Theory on a Lump Sum Tax with more recent literature. The purpose of this analysis is to shine new light on how a Lump Sum Tax might be better implemented in the future. Also considered are to how to maximize efficiency in a tax scheme while minimizin
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Huang, Zhen, Qiang Wei, Xuechun Xiao, Yonghong Xia, Marco Rivera, and Patrick Wheeler. "Enhanced Dual–Vector Model Predictive Control for PMSM Drives Using the Optimal Vector Selection Principle." Energies 16, no. 22 (2023): 7482. http://dx.doi.org/10.3390/en16227482.

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The Dual–Vector model predictive control (DV–MPC) method can improve the steady–state control performance of motor drives compared to using the single–vector method in one switching cycle. However, this performance enhancement generally increases the computational burden due to the exponential increase in the number of vector selections, lowering the system’s dynamic response. Alternatively, limiting the vector combinations will sacrifice system steady–state performance. To address this issue, this paper proposes an enhanced DV–MPC method that can determine the optimal vector combinations alon
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Fuady, Ahmad, Nuning Nuraini, Kamal K. Sukandar, and Bony W. Lestari. "Targeted Vaccine Allocation Could Increase the COVID-19 Vaccine Benefits Amidst Its Lack of Availability: A Mathematical Modeling Study in Indonesia." Vaccines 9, no. 5 (2021): 462. http://dx.doi.org/10.3390/vaccines9050462.

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With a limited number of vaccines and healthcare capacity shortages, particularly in low- and middle-income countries, vaccination programs should seek the most efficient strategy to reduce the negative impact of the COVID-19 pandemics. This study aims at assessing several scenarios of delivering the vaccine to people in Indonesia. We develop a model for several scenarios of delivering vaccines: without vaccination, fair distribution, and targeted distribution to five and eight districts with the highest COVID-19 incidence in West Java, one of the most COVID-19-affected regions in Indonesia. W
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Young, Antony R. "The adverse consequences of not using sunscreens." International Journal of Cosmetic Science 45, S1 (2023): 11–19. http://dx.doi.org/10.1111/ics.12897.

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AbstractThe adverse effects of solar ultraviolet radiation (UVR) on normal skin are well established, especially in those with poorly melanized skin. Clinically, these effects may be classified as acute, such as erythema or chronic such as keratinocyte and melanocyte skin cancers. Apart from skin type genetics, clinical responses to solar UVR are dependent on geophysical (e.g., solar intensity) and behavioural factors. The latter are especially important because they may result in ‘solar overload’ with unwanted clinical consequences and ever greater burdens to healthcare systems. Correctly use
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Yeoman, AD, H. Ahmed, A. Akbari, et al. "The development of Liver Research Cymru, a new partnership to increase hepatology research activity in Wales." NIHR Open Research 4 (October 8, 2024): 57. http://dx.doi.org/10.3310/nihropenres.13663.1.

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Background The incidence and severity of liver disease in the United Kingdom have increased over the last 20 years. Many patients present with advanced disease with limited treatment options and subsequently high morbidity and mortality. There was also a significant correlation with deprivation. Strategies that support the earlier detection of liver disease are paramount to reverse this trend. Despite significant progress in terms of novel pathways, the optimal strategy for early detection of liver disease remains unknown. Novel ways to tackle the deprivation gradient and reduce health inequal
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Zaki Awang Chek, Mohd, Isma Liana Ismail, and Nur Faezah Jamal. "Optimising Contribution Rate for SOCSO’s Invalidity Pension Scheme: Actuarial Present Value (APV)." International Journal of Engineering & Technology 7, no. 4.33 (2018): 83. http://dx.doi.org/10.14419/ijet.v7i4.33.23491.

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This study proposes the optimization of the contribution rate for Social Security Organization (SOCSO)’s Invalidity Pension Scheme (IPS). This study aims to statistically analyses the current situation of the contribution fund collection and the claim benefits payment under SOCSO’s IPS. It seeks to develop an actuarial formulation based on the benefits coverage from SOCSO’s IPS. It attempts to determine an optimal contribution rate to support the benefits provided under SOCSO’s IPS using an actuarial approach. It proposes an appropriate contribution rate to be implemented by SOCSO. Currently,
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Zajkowska-Sierpniak, Aleksandra, Marlena Cąkała, Magdalena Kozioł, Kamila Podgórniak, Michał Szymchel, and Filip Grzegorzak. "benefits of triathlon disciplines in maintaining good health - a review of the literature." Quality in Sport 22 (September 17, 2024): 54322. http://dx.doi.org/10.12775/qs.2024.22.54322.

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Introduction: A triathlon is a multisport event comprising three individual disciplines: swimming, cycling and running. The event is structured around two transition periods, during which competitors change from one mode of transportation to another. The multidisciplinary nature of triathlon places an exceptional physiological burden on athletes, with modifications to haemodynamic, biochemical, cardiorespiratory and metabolic parameters. Participation in triathlon has been linked with a number of benefits, including improved endurance, body toning and enhanced laboratory results. However, this
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Yeh, Jennifer M., Claudia L. Seguin, Jillian Whitton, et al. "Benefits, harms, and burden of colorectal cancer screening among childhood cancer survivors previously treated with abdominal-pelvic radiation." Journal of Clinical Oncology 40, no. 16_suppl (2022): 10015. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.10015.

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10015 Background: Survivors of childhood cancer treated with abdominal-pelvic radiation are at increased risk for colorectal cancer (CRC). The Children’s Oncology Group recommends early initiation of CRC screening at age 30, yet the benefits and burden are unknown. Methods: We used incidence and mortality data from the Childhood Cancer Survivor Study to modify the SimCRC model from the Cancer Intervention and Surveillance Modeling Network (CISNET) to reflect high CRC and competing mortality risks among survivors, assuming the elevated cancer risk arises from higher adenoma onset. Strategies ev
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Pantha, Buddhi, Hem Joshi, and Naveen Vaidya. "Controlling Rabies Epidemics in Nepal with Limited Resources: Optimal Control Theory Approach." Mathematics in Applied Sciences and Engineering 99, no. 99 (2020): 1–18. http://dx.doi.org/10.5206/mase/10847.

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In many developing countries, including Nepal, rabies epidemics constitute a serious public health concern, partly because of limited resources for proper implementation of control measures. In this study, we develop an extended model by incorporating various controls into the transmission dynamics model with both dog and jackal vectors. We apply the optimal control theory on the developed model system to identify optimal control strategy for mitigating rabies burden in Nepal with limited resources. Among the potential control strategies, human vaccination, dog vaccination, dog culling, dog st
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Yang, Jun, Rui Zhang, Qiuye Sun, and Huaguang Zhang. "Optimal Wind Turbines Micrositing in Onshore Wind Farms Using Fuzzy Genetic Algorithm." Mathematical Problems in Engineering 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/324203.

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With the fast growth in the number and size of installed wind farms (WFs) around the world, optimal wind turbines (WTs) micrositing has become a challenge from both technological and mathematical points of view. An appropriate layout of wind turbines is crucial to obtain adequate performance with respect to the development and operation of the wind power plant during its life span. This work presents a fuzzy genetic algorithm (FGA) for maximizing the economic profitability of the project. The algorithm considers a new WF model including several important factors to the design of the layout. Th
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Conway, Susan E., and Todd R. Marcy. "Extended Therapy for Primary and Secondary Prevention of Venous Thromboembolism." Journal of Pharmacy Practice 23, no. 4 (2010): 313–23. http://dx.doi.org/10.1177/0897190010366930.

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Clinical practice guidelines currently suggest extended anticoagulation therapy for primary and secondary prevention of venous thromboembolism (VTE). The optimal duration of anticoagulation has been an active area of clinical investigation for patients undergoing orthopedic surgeries and those diagnosed with a first episode of unprovoked VTE. Practice guidelines, VTE incidence, clinical predictors/mediators, and clinical trial evidence is reviewed to help pharmacists and other health care providers make an informed, patient-specific decision on the optimal duration of anticoagulation therapy.
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Kakaulina, M. O. "Priority Socio-Economic Development Areas: Their Effectiveness and Role in the Formation of an Optimal Tax Burden." Economics, taxes & law 11, no. 4 (2018): 78–89. http://dx.doi.org/10.26794/1999-849x-2018-11-4-78-89.

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The relevance of the research is due to the fact that priority socio-economic development areas (PSEDA) can be viewed as «growth points» for regional economies and are positioned as areas enjoying preferential taxation treatment. In this regard, it is extremely important to assess the optimality of the current tax burden level in a PSEDA with respect to resident enterprises. The purpose of research was a comprehensive study of a PSEDA located in the Amur Region by evaluating the effectiveness of the PSEDA operation; construction of an econometric model for assessing the impact of the tax burde
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Nugraha, Lucas Nando. "PAIN IN DIABETES MELLITUS AND BRONCHOSCOPY PROCEDURES: BREAKTHROUGHS IN MANAGEMENT AND CARE." Berkala Ilmiah Kedokteran Duta Wacana 8, no. 1 (2023): 1. http://dx.doi.org/10.21460/bikdw.v8i1.663.

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Overall, these two studies provide valuable insights into efforts to reduce pain burden in patients with diabetes mellitus and patients undergoing bronchoscopic procedures. In the context of diabetes mellitus, understanding the characteristics of pain in patients can help in better management. Meanwhile, the use of music as a non-pharmacological therapy in bronchoscopy procedures shows potential to reduce pain and anxiety in patients. However, further research is needed to gain a deeper understanding, as well as to overcome existing limitations, and provide optimal benefits for patients.
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Prasad-Reddy, Lalita, Alvin Godina, Ashwin Chetty, and Diana Isaacs. "Use of Continuous Glucose Monitoring in Older Adults: A Review of Benefits, Challenges and Future Directions." European Endocrinology 18, no. 2 (2022): 116. http://dx.doi.org/10.17925/ee.2022.18.2.116.

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Many new technologies have been developed over the past decade, and these have substantially changed the way diabetes is managed. Continuous glucose monitoring is now the standard of care for many people living with diabetes, and among its numerous benefits, it has been shown to improve glycaemic outcomes and enhance quality of life. Older adults carry a high burden of diabetes and have a high risk of hypo-glycaemia and hypo-glycaemic unawareness, and continuous glucose monitoring can help to improve glycaemic management in this vulnerable population. Unfortunately, only a few trials have eval
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S. Purnamasari. "BDI Funds Allocation Through Kotaku Towards The Development of Pasar Lama Kelurahan Banjarmasin Tengah Viewed from The Impact and Islamic Economy." Journal of Sustainable Development Science 2, no. 1 (2020): 14–23. http://dx.doi.org/10.46650/jsds.2.1.899.14-23.

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Islam sees economic development as the growth of human maturity, where the material progress that is currently inevitable and that must be supported by the strength of spiritual maturity so that prosperity is achieved. Benefit can be achieved when what emerges from a process is benefit and blessing. However, not everything that is beneficial can provide a blessing. The impact of the allocation of BDI KOTAKU funds on the economic development of Pasar Lama Kelurahan, Banjarmasin Tengah in 2017 was well utilized by the allocation of its use and could improve the economy and welfare of the citizen
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Jonah, Arumona O., Orbunde B. Bemshima., and Musibau BELLO. "Capital Structure, Dividend Policy and Firm Value of Listed Non-Financial Companies in Nigeria." International Journal of Research and Innovation in Social Science VIII, no. IV (2024): 1279–96. http://dx.doi.org/10.47772/ijriss.2024.804096.

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A balance is required for optimal capital structure and dividend policy becomes crucial, as an imbalance could result in increased debt burdens, higher interest payments, and reduced overall profitability. Additionally, such misalignment might erode investor confidence, causing fluctuations in stock prices and, in extreme cases, leading to a decline in market capitalization. Given the foregoing, this study examined the effect of capital structure and dividend policy and firm value of listed non-financial firms in Nigeria. To achieve these objectives, ex post research design was employed and th
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Mutia, Eka Septi Seliani, Fatma Siti Fatimah, and Muhammad Zia Ulhaq. "Edukasi asuransi kesehatan pada remaja pranikah desa donorojo, Kabupaten Magelang." Jurnal Atma Inovasia 3, no. 2 (2023): 186–90. http://dx.doi.org/10.24002/jai.v3i2.6943.

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Health checks before marriage are carried out to find out how the health condition of the prospective bride and groom. in preventing health problems in oneself, spouse and offspring in order to build a good and prosperous family. Health Insurance is a protection that should be owned when married, insurance provides benefits to free participants from the difficulty of providing cash data, health costs that can be monitored and the availability of health data with health insurance, families will get optimal care when sick or postpartum so that prospective fathers and mothers are not burdened wit
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Betemariam, Tesfamariam Aklilu, Holly Morgan, and Divaka Perera. "REVIVED BCIS-2: update and key learnings." Current Opinion in Cardiology 39, no. 5 (2024): 431–36. http://dx.doi.org/10.1097/hco.0000000000001158.

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Purpose of review This review summarises the shifting paradigms in the treatment of ischemic left ventricular dysfunction, spotlighting the revascularization for ischemic ventricular dysfunction-British cardiovascular intervention society-2 (REVIVED-BCIS2) trial results and its impact on key therapeutic goals: survival, left ventricular function, arrhythmia prevention, quality of life and viability testing. Recent findings The REVIVED-BCIS2 trial, and its subsequent sub studies highlighted that (PCI) does not provide additional benefits to optimal medical therapy in terms of improving survival
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Fernandez Montes, Ana Fernandez, Francisca Vazquez Rivera, Nieves Martinez Lago, et al. "Identification of the optimal patients for trifluridine/tipiracil (FTD/TPI) treatment in mCRC: A Spanish real-world analysis." Journal of Clinical Oncology 38, no. 4_suppl (2020): 146. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.146.

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146 Background: FTD/TPI has demonstrated significantly overall survival (OS) and progression-free survival (PFS) in patients (pts) with metastatic colorectal cancer (mCRC) refractory to standard therapies. Nevertheless, data regarding the pt profile that benefits most from this FTD/TPI is scarce. Some reports have shown optimal benefit for pts with low tumor burden indolent disease, ECOG PS 0-1, and no liver metastasis. Methods: We conducted a retrospective, multicenter, observational study of pts treated with FTD/TPI at eight hospitals from the Galician Research Group on Digestive Tumours (GI
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