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Gonzalez, Agustin L., Eric Donnenfeld, Christophe Baudouin, Edward Holland, Kelly Nichols, Paul Karpecki, Mohamed Hamdani, and Amir Shojaei. "LIFITEGRAST 5% FOR DRY EYE DISEASE: COMBINED EFFICACY AND SAFETY FROM FIVE RANDOMIZED CONTROLLED TRIALS." Innovation in Aging 3, Supplement_1 (November 2019): S264. http://dx.doi.org/10.1093/geroni/igz038.983.
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Abstract Five randomized, double-masked, placebo-controlled trials were conducted in the US in adults with DED, an eye dryness score (EDS, visual analogue scale [VAS], 0–100) ≥40, and inferior corneal staining score ([ICSS], 0-4) ≥2.0 at study entry: four 84-day efficacy trials (phase 2, lifitegrast n=58, placebo, n=58; phase 3: OPUS-1, n=293, n=295; OPUS-2, n=358, n=360; OPUS-3, n=355, n=356) and a 1-year safety study (SONATA, lifitegrast n=220, placebo n=111). The pooled population had a mean age of 59.4 years, and 76% were females. Lifitegrast treatment, versus placebo, significantly improved EDS from baseline to day 84 in three of the four trials: OPUS-1 (treatment effect [TE] 4.7; P=0.0311), OPUS-2 (TE 12.3; P<0.0001), and OPUS-3 (TE 7.5; P=0.0003). Lifitegrast significantly improved ICSS in the phase 2 (TE 0.25; P=0.0498) and OPUS-1 (TE 0.23; P=0.0007) trials, and nominally in OPUS-3 (TE 0.17; nominal P=0.0135). The responder analyses from OPUS-2 and OPUS-3 assessed the proportion of subjects with an EDS reduction from baseline (≥10, ≥15, ≥20 points), and percentage change from baseline (≥30, ≥50, ≥70%), to days 14, 42 and 84. More subjects achieved ≥30% EDS reduction with lifitegrast versus placebo in Opus-2, and Opus 3 at days 14, 42, and 84 (all nominal P<0.0001). A similar trend was seen at other response thresholds. Pooled safety data (lifitegrast n=1287; placebo, n=1177) indicated Lifitegrast was well tolerated with no serious ocular adverse events. Lifitegrast significantly improved signs and symptoms of DED in adult subjects, with EDS improvements observed starting at day 14 after treatment.
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Hastrup, Lene Halling, Christian Kronborg, Mette Bertelsen, Pia Jeppesen, Per Jorgensen, Lone Petersen, Anne Thorup, Erik Simonsen, and Merete Nordentoft. "Cost-effectiveness of early intervention in first-episode psychosis: economic evaluation of a randomised controlled trial (the OPUS study)." British Journal of Psychiatry 202, no. 1 (January 2013): 35–41. http://dx.doi.org/10.1192/bjp.bp.112.112300.
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BackgroundInformation about the cost-effectiveness of early intervention programmes for first-episode psychosis is limited.AimsTo evaluate the cost-effectiveness of an intensive early-intervention programme (called OPUS) (trial registration NCT00157313) consisting of enriched assertive community treatment, psychoeducational family treatment and social skills training for individuals with first-episode psychosis compared with standard treatment.MethodAn incremental cost-effectiveness analysis of a randomised controlled trial, adopting a public sector perspective was undertaken.ResultsThe mean total costs of OPUS over 5 years (€123683, s.e. = 8970) were not significantly different from that of standard treatment (€148751, s.e. = 13073). At 2-year follow-up the mean Global Assessment of Functioning (GAF) score in the OPUS group (55.16, s.d. = 15.15) was significantly higher than in standard treatment group (51.13, s.d. = 15.92). However, the mean GAF did not differ significantly between the groups at 5-year follow-up (55.35 (s.d. = 18.28) and 54.16 (s.d. = 18.41), respectively). Cost-effectiveness planes based on non-parametric bootstrapping showed that OPUS was less costly and more effective in 70% of the replications. For a willingness-to-pay up to €50000 the probability that OPUS was cost-effective was more than 80%.ConclusionsThe incremental cost-effectiveness analysis showed that there was a high probability of OPUS being cost-effective compared with standard treatment.
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Starzer, Marie, Carsten Hjorthøj, Nikolai Albert, Merete Nordentoft, and Helene Lund Sørensen. "S121. OPUS 20, 20 YEAR FOLLOW-UP ON THE OPUS TRIAL." Schizophrenia Bulletin 46, Supplement_1 (April 2020): S81—S82. http://dx.doi.org/10.1093/schbul/sbaa031.187.
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Abstract Background Since the first OPUS trial 20 years ago, structured clinical assessments have been collected from a cohort of first episode psychosis patients at 2, 5 and 10 years follow-up. They found that the symptomatology of patients clustered in distinct groups, and they were able to determine stable long-term trajectories of positive and negative symptoms. The Suffolk County Medical health project has followed patients after a first episode psychosis for 20 years. They also found a stable course of trajectories but with an overall significant worsening of symptom severity over time. The 20 year OPUS follow-up will give us the first opportunity to assess the long term outcome in a large representative cohort treated within modern mental health services with treatment available for all. Methods From 1998 to 2000 578 participants were randomized to OPUS or TAU. Baseline characteristics of the cohort were as follows: mean age 26.6 years, 59% were males, 66% had a diagnosis of schizophrenia and 27% had a secondary diagnosis of alcohol or substance abuse At the 20 year follow-up the investigators will be blinded to the original treatment allocation. The patients who wish to participate will be assessed using SAPS, SANS, SCAN, PSP and GAF. Socio-demographic factors and suicidal ideation will be register via self report. Cognitive function will be tested using BACS and all participants will be asked to fill out a number of self-rating questioners including WHO quality of life-BREF, self-perceived health, strengths and difficulties, the parenting scale and self-perceived negative symptoms. Using national Danish registers we can collect information on all former participants regarding the use of psychiatric and general healthcare services, medication, supported housing or homelessness, employment status, substance abuse and mortality. Results The OPUS 20 study started collecting data in Jan 2018. We are attempting to contact as many patients as possible from the 578 participants in the original OPUS cohort. At the time of writing we had included data and attempted contact to 322 participants. Overall 104 people (31,7%) have agreed to participate in the interviews. In the follow-up 10 years ago, the participation-rate was 60% so this is a big drop in participation rate. 41 (14%) have died, 31 (9,5%) were lost due to emigration, homelessness or hidden identity and/or disempowerment. 70 (21,3%) didn’t wish to participate and 76 (23,2%) never responded. Discussion Psychotic disorders and schizophrenia in particular are associated with progressive worsening of symptoms and profound social impairment, and as such are still very stigmatized. Results from the 10 year OPUS follow-up found stable trajectories of positive and negative symptoms over time, with a tendency of reduction and stabilization of positive symptoms but less variation of negative symptoms. They found poor but stable social functioning with a mean GAF score of 55 after 10 years. The Suffolk County mental health project also found stable trajectories of psychopathology measured with SAPS and SANS. They however found progressive worsening of GAF scores declining form 49 points at the beginning to 36 after 20 years. So far we have seen stable GAF scores and SAPS and SANS scores compared to OPUS 10. This gives rise to some optimism about the prognosis for schizophrenia compared to the findings of the Suffolk study. In our study the extensive interviews combined with the data collected form Danish registers give us a unique opportunity to look at the long term course of illness after FEP. The ability to test if previous findings are robust over time will be essential to the development of targeted interventions, differentiated to the needs of different patient groups.
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Zaninotto, Martina, Franca Pagani, Sara Altinier, Paolo Amboni, Roberto Bonora, Alberto Dolci, Patrizia Pergolini, Arialdo Vernocchi, Mario Plebani, and Mauro Panteghini. "Multicenter Evaluation of Five Assays for Myoglobin Determination." Clinical Chemistry 46, no. 10 (October 1, 2000): 1631–37. http://dx.doi.org/10.1093/clinchem/46.10.1631.
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Abstract Background: Lacking assay standardization, different myoglobin methods may produce results that differ significantly. Methods: A multicenter study was carried out to compare the analytical performance of five commercially available assays for myoglobin measurement. Linearity, imprecision, interferences, and method comparison were studied according to NCCLS guidelines, whereas reference values were determined following IFCC recommendations. Results: The BNA and Opus showed relatively high imprecision (all but one total CV >7.4%). Other assays showed lower CVs, but they varied among laboratories, particularly at a normal myoglobin concentration (Access, 6.0–11%; Hitachi, 3.8–5.8%; Stratus, 3.4–6.5%). Results were lower in anticoagulated samples on the Access, in heparin and citrate samples on the Stratus, and in citrate samples on the BNA and Opus, and increased in heparin and EDTA samples on the Hitachi. Use of separator gel produced results significantly lower (P <0.001) on the Hitachi and higher (P = 0.016) on the Opus. Bilirubin, turbidity, and hemoglobin had no effect on evaluated methods, but rheumatoid factor affected the Access. In method comparisons, high correlation coefficients (≥0.98) were obtained. The Stratus gave higher results; however, the Access and BNA gave the lowest. The following upper reference limits (μg/L) for men and women, respectively, were obtained: Access, 70 and 52; BNA, 51 and 49; Hitachi, 67 and 58; Opus, 80 and 50; and Stratus, 86 and 63. Conclusion: The possibility of high imprecision and marked disagreement among commercial myoglobin assays should be carefully considered in clinical practice.
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Amodeo, Britta, Aline Schindler, Ulrike Schacht, and Hans Günther Wahl. "Calculation of indirect reference intervals of plasma lipase activity of adults from existing laboratory data based on the Reference Limit Estimator integrated in the OPUS::L information system." Journal of Laboratory Medicine 45, no. 2 (April 1, 2021): 131–34. http://dx.doi.org/10.1515/labmed-2021-0008.
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Abstract Objectives Most laboratories have difficulties to determine their own reference intervals for the diagnostic evaluation of patient results by direct methods. Therefore, data is often just taken from the literature or package inserts of the analytical tests. Methods The section on Reference Limits of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) first uploaded the Reference Limit Estimator (RLE) as an R-program with MS Excel-interface on the DGKL home page and now this tool is implemented in the commercial Laboratory Information System OPUS::L (OSM AG Essen, Germany). We used this OPUS::L “Population specific Reference Limits” tool online with our laboratory database. First calculations were done using the example of lipase. Results The manufacturer’s original reference interval for lipase 12–53 U/L (adults) was changed to age dependent upper reference limits of <41 U/L (<20 years), <60 U/L (20–80 years) and <70 U/L (>80 years). Conclusions By means of the OPUS::L “Population specific Reference Limits” tool we were able to establish our laborarotry specific reference interval for plasma lipase activity. The new reference limits helped to solve an old problem of implausible low elevated lipase values.
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Montero Díaz, Mercedes. "De la narrativa del estereotipo a la narrativa del silencio: cómo se ha contado la historia de Ediciones Rialp, S. A. (1948-2018)." Hispania Sacra 73, no. 147 (June 29, 2021): 273–87. http://dx.doi.org/10.3989/hs.2021.023.
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El artículo se centra en el análisis histórico de Ediciones Rialp, S.A. y en las dos narrativas más importantes desarrolladas por la historiografía española en torno a su proyecto cultural. Al mismo tiempo, se estudian sus relaciones con el Opus Dei y la influencia que este hecho haya podido tener en la elaboración de las narrativas descritas. Simultáneamente, se propone una nueva manera de afrontar la historia de esta empresa cultural que cumple ya más de 70 años, y es la única de su tiempo que conserva tanto la independencia como la línea editorial.
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Todd, R. Larry, Felix Mendelssohn, Michael Pilkington, and Christian Rudolf Riedel. "Elijah: An Oratorio for Soprano, Alto, Tenor and Bass Soli, SATB, Orchestra and Organ, Opus 70. Vocal Score." Notes 50, no. 2 (December 1993): 745. http://dx.doi.org/10.2307/898515.
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Levy, Jason, Elizabeth David, Thomas Hopkins, Jonathan Morris, Nam D. Tran, Hamed Farid, Francesco Massari, et al. "Radiofrequency ablation for palliative treatment of osseous metastases results in rapid, significant, and durable improvements in pain relief and quality of life: Results from the OPuS One trial." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 12086. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.12086.
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12086 Background: Patients with bone metastases may experience pain and decreased quality of life. Standard of care therapies such as radiation therapy could take weeks for pain relief and carry a risk of radiation induced fracture. Minimally invasive percutaneous radiofrequency ablation (RFA) have been shown in small observational studies to be an alternative treatment for bone metastases. We report the results of the OPuS One trial evaluating RFA for the palliative treatment of patients with painful bone metastases. Methods: OPuS One (NCT03249584) was a multicenter prospective trial. 218 subjects with painful bone metastases (≥ 4/10 worst pain scores, Brief Pain Inventory [BPI], at target treated site) were enrolled from 15 sites. RFA was performed under image guidance at one or two locations. Vertebral augmentation was followed based on physician’s discretion. Subjects’ pain (BPI) and quality of life (EQ-5D) scores were calculated in subjects at three days, one week, and one, three, six, and 12 months post RFA. Rate of complete (0 pain score at treated site with no concomitant analgesic increase) and partial responders (≥ 2 pain score reduction without analgesic increase or analgesic reduction of ≥ 25% from baseline) were calculated. Device-, procedure-, and/or therapy-related adverse events (AEs) were collected. Results: 206 subjects, 113 (55%) female and 93 (45%) males (mean age was 63.7 years) were treated with RFA. Most common primary cancers were breast (23%), lung (23%), and kidney (10%). 184 (89%) subjects were treated for metastatic lesions involving the thoracolumbar spine and 22 (11%) subjects were treated for iliac crest, periacetabulum, sacrum or mixed vertebral and pelvic location. 99% (262/264) of RFA procedures were technically successful and 97% were followed by vertebral augmentation. Subjects reported significant improvement in worst pain from baseline at 7.8 to 5.5, 4.7, 3.6, 3.2, 2.4, and 2.6 at three days, one week and one, three, six, and 12 months post RFA, respectively (p < 0.0001 for all visits). Significant improvements were also seen in average pain (p < 0.0001 for all visits), pain interference (p < 0.0001 for all visits), and quality of life scores (p < 0.0001 for all visits). Overall response rates were 53%, 58%, 61%, 63%, 70%, and 75% at three days, one week, one month, three months, six months, and twelve months post RFA, respectively. Six AEs were reported with three as serious: intra-abdominal fluid collection, pneumonia and respiratory failure. 82 deaths were reported during the study, none were related to the device, therapy, and/or procedure. No skeletal related events were reported. Conclusions: In a large prospective multicenter trial, OPuS One, RFA provided rapid, significant, and durable improvements in pain relief and quality of life up to 12 months. Clinical trial information: NCT03249584.
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Efimenko, S. G., and S. K. Efimenko. "Rapid assessment of oil and moisture content in seeds of oil flax using IR spectrometry." Oil Crops 3, no. 183 (November 30, 2020): 63–70. http://dx.doi.org/10.25230/2412-608x-2020-3-183-63-70.
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We used near-infrared reflectance spectroscopy (NIRS) to assess biochemical parameters in whole oil flax seeds, regardless of differences in seed coat color of the samples. At the first stage of work, the set the task to develop calibration models for the MATRIX-I IR analyzer to determine the oil and moisture content in flax seeds. The carried out the research in the laboratory of biochemistry on brown and yellow seed samples of oil flax, grown in 2015-2020 in various agro-ecological conditions of the Russian Federation. We determined the oil content on an AMV 1006M NMR analyzer in accordance with the GOST 8.597- 2010 measurement procedure; we assessed the moisture content by the standard method of GOST 10856- 96. We used the results of determination of the oil and moisture content of the seeds of test lot in accordance with the accuracy indicator of the calibration of GOST 32749-2014 to verify the reliability of the developed models. We received the best indicators of the quality of calibration models (root-mean-square prediction error, coefficient of determination and the value of the residual deviation of prediction for the rank displayed on the graph) by determining the oil content (RMSEP = 0.27 %, R2 = 99.2 and RPD = 11.2) and moisture content (RMSEP = 0.06 %, R2 = 99.9 and RPD = 39). In the OPUS LAB program we developed the “Flax 51” method for mass analysis based on the developed calibration models for the determination of oil and moisture content in whole oil flax seeds (9-20 g) in a sample cell with a diameter of 51 mm. It enables the quick carrying out a preliminary assessment of the breeding material at a high speed – more than 120 samples in 7 hours without seed destruction.
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Panteghini, Mauro, Franca Pagani, Kiang-Teck J. Yeo, Fred S. Apple, Robert H. Christenson, Francesco Dati, Johannes Mair, Jan Ravkilde, and Alan H. B. Wu. "Evaluation of Imprecision for Cardiac Troponin Assays at Low-Range Concentrations." Clinical Chemistry 50, no. 2 (February 1, 2004): 327–32. http://dx.doi.org/10.1373/clinchem.2003.026815.
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Abstract Background: The European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction (MI) has recommended that an increased cardiac troponin should be defined as a measurement above the 99th percentile value of the reference group. A total imprecision (CV) at the decision limit of ≤10% is recommended. However, peer-reviewed data on assay imprecision are lacking. The purpose of this study was to construct the clinically relevant imprecision profiles for each of the commercially available cardiac troponin assays. Pools of human sera containing cardiac troponin concentrations around the MI decision limit were assessed to identify the lowest concentration associated with a 10% CV. Methods: Eight serum pools targeting different concentrations of cardiac troponin (I and T) were prepared and stored at −70 °C until usage. The cardiac troponin measurement protocol consisted of two replicates per specimen per run, and one run per day for 20 days, using two reagent lots and three calibrations. Manufacturers of each cardiac troponin assay directly performed the measurements. Data analysis for each assay was centralized and performed according to the NCCLS EP5-A guideline. Results: The lowest concentrations (μg/L) providing a 10% CV were as follows: AxSYM, 1.22; ACS:180, 0.37; Centaur, 0.33; Immuno 1, 0.34; Access, 0.06; Vidas, 0.36; Liaison, 0.065; Dimension, 0.26; Opus, 0.90; Stratus CS, 0.10; Immulite, 0.32; Vitros ECi, 0.44; Elecsys, 0.04; AIA 21, 0.09. Conclusion: No cardiac troponin assay was able to achieve the 10% CV recommendation at the 99th percentile reference limit defined by the manufacturer.
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Bokemeyer, C., I. Bondarenko, A. Makhson, J. T. Hartmann, J. Aparicio, M. Zampino, S. Donea, H. Ludwig, A. Zubel, and P. Koralewski. "Cetuximab plus 5-FU/FA/oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized phase II study." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 4035. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4035.
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4035 Background: FOLFOX-4 is a standard first-line treatment for patients (pts) with mCRC. The IgG1 monoclonal antibody cetuximab has proven activity in combination with cytotoxic chemotherapy. Excellent response rates (RRs) have been reported with first-line cetuximab and FOLFOX-4. This randomized, controlled study was conducted to compare RRs of FOLFOX-4 + cetuximab vs FOLFOX-4. Methods: Pts with previously untreated epidermal growth factor receptor (EGFR)-expressing mCRC not resectable with curative intent were eligible. They were randomized 1:1, stratified by ECOG performance status (PS) (0–1 vs 2), to either Group A (cetuximab 400 mg/m2 initial dose then 250 mg/m2/week plus FOLFOX-4 every 2 weeks [oxaliplatin 85 mg/m2 day (d) 1; FA 200 mg/m2 d1, 2; 5-FU 400 mg/m2 bolus + 600 mg/m2 infusion over 22 h, d1, 2]) or Group B (FOLFOX-4 only). The primary objective was the best confirmed RR assessed by independent review; secondary objectives were progression- free survival (PFS), overall survival (OS), the R0 resection rate after metastatic surgery of curative intent and safety. Results: Between July 2005 and March 2006, 337 pts were randomized and treated in more than 70 centers in Europe. 181 (53.7%) pts were male; the median age of all pts was 61.0 years [24–82]; 305 (90.5%) pts had an ECOG PS of 0 or 1, and 32 (9.5%) of 2. The best overall confirmed RR was 45.6% in A and 35.7% in B. For pts with ECOG PS 0–1, RR was 49.0% in A and 36.8% in B (Odds Ratio 1.648, 95%CI [1.043- 2.604]). PFS and OS results are not yet available. The most common grade 3/4 adverse events were neutropenia (27.6% in A; 31.5% in B), diarrhea (7.1 and 6.0%), leucopenia (7.1 and 5.4%) and rash (9.4%, in A only). Conclusions: The addition of cetuximab increased the RR of FOLFOX-4 in first-line treatment of mCRC. Grade 3/4 adverse events, with the exception of skin rash, were not significantly more frequent in the cetuximab arm. No significant financial relationships to disclose.
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Mineur, Laurent, Gilles Seni, Laurent Miglianico, louis-Marie Dourthe, Nathalie Bonichon, Lionel Moreau, Rosine Guimbaud, et al. "Safety and efficacy during first line with cetuximab in KRAS wild-type metastatic colorectal cancer (mCRC): Results of a large prospective multicenter cohort carried out by the premium French observational study." Journal of Clinical Oncology 31, no. 4_suppl (February 1, 2013): 555. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.555.
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555 Background: Cetuximab improves benefit in patients with kras wild type when added to CT for mCRC (Crystal, opus, celim trials). In order to assess the safety and efficacy of cetuximab in daily-practices a national prospective observational multicenter study was performed. Methods: Physicians (n=94), in health institutions (44 public and 46 private hospitals, 4 cancer centers) enrolled prospectively 502 patients. The eligibility criteria were kras wild type mCRC treated with cetuximab in combination with CT as first-line regimen and at least one measurable lesion. Data are available at 3 months, for 496 patients enrolled between september 2009 to march 2012. Results: Mean age 65,7 years old, 62.9% male, ECOG score 0-1 88.1%, 2-3 11.9%, metastases site were liver 70%, lung 26% and others unlimited 39%. Resectable mCCR 10.6%, potentially resectable metastases 33.9% and unresectable 55.5%. Primary tumor location colon: right 20.9%, transverse 6%, left 35.3%, rectum 30.5%, others 7.3%. Primary cancer was resected in 66 % (n=332), 25% (n=125) received adjuvant CT. Cetuximab was administrated respectively every week(20.2%) or two weeks (79.8% of patients). CT regimens were folfiri 51.8%, folfox 4 36.5%, others 11.7%. At 3 months response rate was complete in 4.6%, partial 44.9%, stable 34%, progression disease 16.5%. Reasons for specific cetuximab treatment discontinuation (n=207) were progressive disease 35.3%, therapeutic break 23.2%, all grade cutaneous toxicity and allergic reaction 15.9%, patient request 2.9%, surgery recruitment 20% radiotherapy, radiofrequency and others 2.7%. Adverse events in grade 2 and 3-4 were respectively neutropenia (9.4%;7.9%), anemia (8.5%;1.4%), thrombocytopenia (2.6%;1%), diarrhea (10.8%;5.3%) vomiting (5.3%;2.2%), folliculitis (17.9%;3%), xerosis (13.3%;2%), paronychia (5%;0.9%), allergy 3.4%. Conclusions: Values reported are consistent with those previously identified trials and can better understand the reasons of drug stopping. The study continues to evaluate prognostic factors influencing response, toxicity and drug discontinuation.
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Poethke, Günter. "Emas non quod opus est, sed quod necesse est. Beiträge zur Wirtschafts-, Sozial-, Rezeptions- und Wissenschaftsgeschichte der Antike. Festschrift für Hans-Joachim Drexhage zum 70. Geburtstag. Hrsg. von Kai Ruffing und Kerstin Droß-Krüpe (Philippika 125). Wiesbaden: Harrassowitz 2018." Archiv für Papyrusforschung und verwandte Gebiete 66, no. 1 (July 1, 2020): 192–97. http://dx.doi.org/10.1515/apf-2020-0011.
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Ljuca, Dženita, Zlatan Fatušić, Ermina Iljazović, and Begzudin Ahmetović. "Monitoring of chemotherapy successfulness of Platina/Taxol chemotherapy protocol by using determination of serum urokinase plasminogen activator (uPA) and soluble urokinase plasminogen activator receptor (suPAR) in patients with ovarian carcinoma FIGO II." Bosnian Journal of Basic Medical Sciences 7, no. 2 (May 20, 2007): 113–18. http://dx.doi.org/10.17305/bjbms.2007.3063.
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In about 70% of cases, ovarian carcinoma has been diagnosed at an advanced stage. Invasion and metastasis of solid tumors request protease activity resulting in basal membrane destruction and surrounding matrix. In that process, urokinase plasminogen activator (uPA) and its receptor, urokinase plasminogen activator receptor (suPAR) play a key role, that via plasmin activation lead to basal membrane and matrix degradation in surrounding of the tumor, enable to its invasion and metastasis. Determination of serum concentration of those tumor markers can be useful in preoperative as well as in postoperative period. Their serum concentrations in ovarian cancer patients may help in good monitoring of remission or progression during chemotherapy treatment. In late 1950s and eariy 1960s, when it was found out that malignant ovarian tumors were chemosensitive, their chemotherapy treatment has begun. In the beginning it was used only mono-therapy, and by discovering new cytostatics it was replaced by poly-chemotherapy. Now days, in the therapy of advanced stages of ovarian carcinoma combination of cisplatine or carboplatine with paclitaxel is considering as standard treatment. Aim of this study was to determine serum uPA, suPAR and CEA in FIGO II and III patients with different histo-logical type (serous, mucinous, clear cell tumor) before and after PT chemotherapy protocol during following three cycles. In this prospective study we have analyzed 17 patients with ovarian carcinoma, those have been after surgery treated by chemotherapy. Serum levels of uPA and suPAR have been determined by ELISA-test (Imubind uPA, Imubind uPAR, American Diagnostica), and CEA by OPUS Imunoassay method. Results of this study have shown that uPA, suPAR and CEA met criteria for prognostic markers for monitoring of successful-ness of platina/taxol chemotherapy protocol for serous, mucinous and clear cell tumor FIGO II and III stage of ovarian carcinoma. In case of PT chemotherapy protocol suPAR was better prognostic marker for monitoring of chemotherapy successfulness (Pearson coefficient 0,9 do 1,0; p<0,00l) than uPA (Pearson coefficient between 0,86 and 0,92; p<0,02) and CEA (Pearson coefficient 0,5 do 0,89; p<0,04).
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Liang, Xianwei, Xiufang Zhang, Bingzhuang Yang, Mingtang Cheng, Fenxiang Huang, Chunying Pang, Guangsheng Qing, et al. "Pregnancy and calving rates following transfer of in-vitro-produced river and F1 (river × swamp) buffalo (Bubalus bubalis) embryos in recipients on natural oestrus or synchronised for ovulation." Reproduction, Fertility and Development 19, no. 5 (2007): 670. http://dx.doi.org/10.1071/rd07048.
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The main objective of this study was to compare pregnancy and calving rates following transfer of in-vitro-produced fresh river and F1 (river × swamp) buffalo embryos in recipients synchronised by Ovsynch protocol or following natural oestrus. River embryos were produced from cumulus–oocyte complexes (COCs) derived by ovum pick up (OPU) on 40 Murrah and Nili-Ravi donor buffaloes over a twice-weekly collection schedule for 120 single OPUs. F1 embryos were produced by fertilisation of swamp COCs recovered from abattoir ovaries coincubated with river sperm cells. Both groups of embryos were produced following the same protocol for in vitro production. With regard to the OPU source of COCs, 923 antral follicles were punctured and 647 COCs were recovered (70%). From 462 selected COCs for IVM, 257 (55.6%) cleaved zygotes were recorded leading to 93 blastocysts (20.1%). In total, 590 swamp COCs were aspirated from abattoir ovaries and 476 were selected for IVM leading to 270 (56.7%) cleaved zygotes and resulting in 137 blastocysts (28.8%). River and F1 embryos were transferred between Day 6 to 7 of in vitro development, corresponding to blastocyst–expanding blastocyst, into F1 recipients synchronised by Ovsynch and swamp buffaloes following natural oestrus, respectively, each of them receiving two embryos. According to palpation per rectum of the ovaries at the time of embryo transfer, 26 of the 47 (55.3%) F1 recipients synchronised by Ovsynch were considered suitable for transfer, resulting in seven pregnancies (26.9%) and four calvings (15.3%) owing to three abortions occurring between 2 and 3 months of pregnancy. In total, 29 swamp recipients following natural oestrus were judged suitable as recipients, resulting in 12 pregnancies (41.4%) and 10 calvings (34.5%) owing to two abortions at 2 and 3 months of gestation respectively. Pregnancy and calving rates following transfer of river and F1 embryos were similar. Likewise, weight at birth of calves derived from transfer of river and F1 embryos was not different: 30.5 ± 1.4 and 32.9 ± 2.4 respectively. Pregnancy and calving rates following AI in a group of river and swamp buffaloes considered for reference in this study were similar to recipients carrying in-vitro-produced embryos. Collectively, no apparent postnatal complications were recorded in resulting live calves.
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Lobón-Iglesias, María Jesús, Ingrid Laurendeau, Léa Guerrini-Rousseau, Arnault Tauziède-Espariat, Audrey Briand-Suleau, Pascale Varlet, Dominique Vidaud, et al. "NF1-like optic pathway gliomas in children: clinical and molecular characterization of this specific presentation." Neuro-Oncology Advances 2, Supplement_1 (December 20, 2019): i98—i106. http://dx.doi.org/10.1093/noajnl/vdz054.
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Abstract Background Pediatric neurofibromatosis type 1 (NF1)–associated optic pathway gliomas (OPGs) exhibit different clinico-radiological features, treatment, and outcome compared with sporadic OPGs. While NF1-associated OPGs are caused by complete loss-of-function of the NF1 gene, other genetic alterations of the RAS-MAPK pathway are frequently described in the sporadic cases. We identified a group of patients who presented OPGs with typical radiological features of NF1-associated OPGs but without the NF1 diagnostic criteria. We aim to investigate into the possible molecular mechanisms underlying this “NF1-like” pediatric OPGs presentation. Methods We analyzed clinico-radiological features of 16 children with NF1-like OPGs and without NF1 diagnostic criteria. We performed targeted sequencing of the NF1 gene in constitutional samples (n = 16). The RAS-MAPK pathway major genes were sequenced in OPG tumor samples (n = 11); BRAF FISH and IHC analyses were also performed. Results In one patient’s blood and tumor samples, we identified a NF1 nonsense mutation (exon 50: c.7285C>T, p.Arg2429*) with ~8% and ~70% VAFs, respectively, suggesting a mosaic NF1 mutation limited to the brain (segmental NF1). This patient presented signs of neurodevelopmental disorder. We identified a somatic alteration of the RAS-MAPK pathway in eight tumors: four BRAF activating p.Val600Glu mutations, three BRAF:KIAA oncogenic fusions, and one putative gain-of-function complex KRAS indel inframe mutation. Conclusions NF1-like OPGs can rarely be associated with mosaic NF1 that needs specific constitutional DNA analyses for diagnosis. Further studies are warranted to explore unknown predisposition condition leading to the NF1-like OPG presentation, particularly in patients with the association of a neurodevelopmental disorder.
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Isański, Jakub. "Wincenty Kuć „Pamiętnik”." Rocznik Ziem Zachodnich 1 (December 29, 2017): 597–624. http://dx.doi.org/10.26774/rzz.187.
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Pamiętnik przedwojennego szewca, którego powojenne losy rzuciły z Warszawy do Wrocławia. Autor wspomnień jest człowiekiem bardzo zaangażowanym w życie społeczne, a jego opis zawiera wiele szczegółów ilustrujących życie społeczne od pierwszych lat po wojnie aż do lat 70. Mimo swoich przedwojennych lewicowych poglądów, autor krytycznie ocenia powojenną polską rzeczywistość – od pierwszych dni swojego osiedlenia się we Wrocławiu, aż do ogólnych warunków życia społecznego lat 70. Pamiętnik zawiera sporo ciekawych informacji o życiu społecznym tamtych czasów.
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Fukushima, M., S. Kawai, and Y. Yamaguchi. "Behavior of Organophosphoric Acid Triesters in Japanese Riverine and Coastal Environment." Water Science and Technology 25, no. 11 (June 1, 1992): 278. http://dx.doi.org/10.2166/wst.1992.0302.
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The long-term monitoring of organophosphoric acid triesters started in 1976 in the Yodo River basin; Lake Biwa, Yodo River and the rivers in Osaka City. An extensive survey was also conducted in the Yamato River and Osaka Bay, Japan. This report presents the current levels and distributions of OPEs as well as the historical trend of TDCPP. Some or all of OPEs studied here have been detected in the entire water samples over the monitoring period. It was clear that OPEs were ubiquitous pollutants in the river and coastal waters. Total OPE levels ranged from 0.4 to 2.4 µgl−1 in the Yodo River basin, 2.4 to 12 µgl−1 in the rivers in Osaka City, 18 to 28 µgl−1 in the Yamato River basin and 0.1 to 1.3 µgl−1 in Osaka Bay. An apparent difference was found in the individual OPE level among the different water areas surveyed. In the Lake Biwa and the Yodo River, the predominant compound was TBXP followed by TCEP and TDCPP. The higher levels were observed for TBXP, TEP, TCPP and TCEP in the rivers in Osaka City. The highest TCPP level, which occupied more than 70% of OPEs' composition, was observed and the mean level reached to 13.1µgl−1 in the Yamato River. In Osaka Bay, 6 kinds of OPEs, except for TPP, TEHP and TCP, were found and the most prevalent compounds were TCEP and TBP. TDCPP had gradually increased in concentration in the Yodo River basin until 1987 from 1976 year by year. However, the reverse trend of TDCPP has been noticed during the last several years.
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Pękala, Mateusz, and Radosław Zyzik. "SPOŁECZNY OBRAZ PRAWA. OPIS OBSZARU BADAŃ I WYNIKI PILOTAŻU." Zeszyty Prawnicze 18, no. 4 (February 1, 2019): 35–65. http://dx.doi.org/10.21697/zp.2018.18.4.02.
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Celem niniejszego artykułu jest prezentacja wyników badania pilotażowego, przeprowadzonego wśród studentów nauk społecznych, którego celem było zidentyfikowanie ich podstawowych intuicji i ocen dotyczących prawa i polskiego systemu prawnego. W Polsce od lat 70. XX w. do dzisiaj prowadzone są badania mające zidentyfikować podstawowe cechy popularnej kultury prawnej, a jedną z tez obecnych w literaturze przedmiotu jest twierdzenie o jej antylegalistycznym charakterze. Pierwsza część pracy poświęcona jest rekonstrukcji dotychczasowych badań nad świadomością prawną społeczeństwa polskiego z uwzględnieniem najważniejszych czynników wpływających na jej kształt. Postawy wobec prawa to niewątpliwie jeden z najważniejszych obszarów badań empirycznych prowadzonych przez przedstawicieli współczesnej socjologii prawa. Druga część artykułu to prezentacja zrealizowanych przez autorów pilotażowych badań nad popularną kulturą prawną studentów. Jednym z głównych celów badawczych jest identyfikacja najczęściej pojawiających się skojarzeń z terminem „norma prawna” oraz generalnych ocen polskiego systemu prawnego. Badania, choć przeprowadzone jedynie w celach eksploracyjnych, pozwoliły na wstępne odniesienie się do obecnej w literaturze przedmiotu hipotezy o antylegalistycznym charakterze polskiej kultury prawnej.
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Kishimoto, Takuya E., Kazuyuki Uchida, Atigan Thongtharb, Tokuhiro Shibato, James K. Chambers, Kazumi Nibe, Yumiko Kagawa, and Hiroyuki Nakayama. "Expression of Oligodendrocyte Precursor Cell Markers in Canine Oligodendrogliomas." Veterinary Pathology 55, no. 5 (May 31, 2018): 634–44. http://dx.doi.org/10.1177/0300985818777794.
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Oligodendroglioma is a common brain tumor in dogs, particularly brachycephalic breeds. Oligodendrocyte precursor cells (OPCs) are suspected to be a possible origin of oligodendroglioma, although it has not been well elucidated. In the present study, 27 cases of canine brain oligodendrogliomas were histologically and immunohistochemically examined. The most commonly affected breed was the French Bulldog ( n = 19 of 27, 70%). Seizure was the most predominant clinical sign ( n = 17 of 25, 68%). The tumors were located mainly in the cerebrum, particularly in the frontal lobe ( n = 10 of 27, 37%). All cases were diagnosed as anaplastic oligodendroglioma (AO) and had common histologic features characterized by the proliferation of round to polygonal cells with pronounced atypia and conspicuous mitotic activity (average, 10.7 mitoses per 10 high-power fields). Honeycomb pattern ( n = 5 of 27, 19%), myxoid matrix ( n = 10, 37%), cyst formation ( n = 6, 22%), necrosis ( n = 19, 70%), pseudopalisading ( n = 5, 18.5%), glomeruloid vessels ( n = 16, 59%), and microcalcification ( n = 5, 19%) were other histopathologic features of the present tumors. Immunohistochemically, the tumor cells were positive for Olig2 in all cases and for other markers of OPCs in most cases, including SOX10 ( n = 24 of 27, 89%), platelet-derived growth factor receptor α ( n = 24, 89%), and NG2 ( n = 23, 85%). The present AO also consisted of heterogeneous cell populations that were positive for nestin ( n = 13 of 27, 48%), glial fibrillary acidic protein ( n = 5, 19%), doublecortin ( n = 22, 82%), and βIII-tubulin ( n = 15, 56%). Moreover, cultured AO cells obtained from 1 case retained expression of OPC markers and exhibited multipotent characteristics in a serum culture condition. Overall, the findings suggest that transformed multipotent OPCs may be a potential origin of canine AO.
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Che Zain, Mohamad Shazeli, Nurul Azani Jakariah, Jen Xen Yeoh, Soo Yee Lee, and Khozirah Shaari. "Ultrasound-Assisted Extraction of Polyphenolic Contents and Acid Hydrolysis of Flavonoid Glycosides from Oil Palm (Elaeis guineensis Jacq.) Leaf: Optimization and Correlation with Free Radical Scavenging Activity." Processes 8, no. 12 (November 26, 2020): 1540. http://dx.doi.org/10.3390/pr8121540.
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Malaysia is ranked as the second largest oil palm producer in the world after Indonesia. This leads to the generation of large quantities of oil palm (Elaeis guineensis Jacq.) leaves (OPLs) annually, considered an underutilized oil palm biomass with low economical value. The present study aimed to study the effects of several parameters of ultrasound-assisted extraction (UAE) and the acid hydrolysis of phenolic compounds from OPLs using the single factor experimental approach. The effects of different solvents (hexane, ethyl acetate, 1:1 methanol–ethyl acetate, absolute methanol, and 4:1 methanol–water), solid–liquid ratios (1:20, 1:40, 1:50, 1:60, and 1:70), times (0.5, 1, 2, 3, and 5 h), and temperatures (25, 30, 40, 60, and 70 °C) were investigated for UAE. Moreover, the effects of acid concentration (0.2, 1, 2, 4, 6, and 12 M), incubation time (10, 30, 45, 60, and 90 min), and incubation temperature (65, 75, 85, 90, and 95 °C) on the acid hydrolysis of flavonoid glycosides were also determined. The results revealed that some of the tested parameters had prominent effects on the total phenolic (TPC) and total flavonoid (TFC) contents, as well as the DPPH free radical scavenging activity recovered from the OPLs. The optimal UAE conditions were determined to be 0.5 h at 25 °C using 4:1 methanol–water and 1:50 solid–liquid ratio, producing OPL extracts with TPC and TFC at 335.30 and 60.67 milligrams quercetin equivalents per gram of extract (mg QCE/g extract), respectively, and DPPH free radical scavenging activity at 94.06%. The phenolics present in OPLs were optimally hydrolysed using 6 M hydrochloric acid with an incubation period of 45 min at 95 °C with TPC, TFC, and DPPH free radical scavenging activity at 126.33 milligrams gallic acid equivalents per gram of extract (mg GAE/g extract), 36.08 mg QCE/g, and 54.88%, respectively. Moreover, acid hydrolysis managed to optimally recover the total apigenin content (TAC), total luteolin content (TLC), and total flavonoid C-glycoside content (TFCGC) with values of 79.12 micrograms vitexin equivalents per milligram of extract (µg VE/mg extract), 20.97 micrograms orientin equivalents per milligram of extract (µg OE/mg extract), and 100.09 µg/mg, respectively. Additionally, there were significant correlations between the polyphenolic compounds, flavonoid C-glycosides, and antioxidant activity for all parameters based on the Pearson correlation analysis. This indicates that OPLs have potential as a natural source of phenolic compounds, especially flavonoid C-glycosides, with beneficial free radical scavenging activity that can be incorporated in food and pharmaceutical products.
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Širvinskas, Audrius, Edgaras Smolskas, Kipras Mikelis, and Gintautas Brimas. "Transkateterinė arterinė embolizacija gydant skrandžio ir dvylikapirštės žarnos opas." Lietuvos chirurgija 15, no. 4 (December 22, 2016): 145–51. http://dx.doi.org/10.15388/lietchirur.2016.4.10277.
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ĮvadasTranskateterinė arterinė embolizacija yra chirurginio gydymo alternatyva. Ji taikoma esant pakartotiniam kraujavimui iš skrandžio ar dvylikapirštės žarnos opos po nepavykusio kraujo stabdymo endoskopijos metu. Mes nagrinėjometranskateterinės embolizacijos efektyvumą, gydymo baigtis ir rodiklius, galinčius turėti įtakos sergamumui bei mirtingumui.MetodaiAtlikome retrospektyviąją analizę, į kurią įtraukėme 20 pacientų, kuriems nuo 2012 m. iki 2015 m. Respublikinėje Vilniaus universitetinėje ligoninėje buvo atlikta transkateterinė arterinė embolizacija dėl ūminio kraujavimo iš viršutinės virškinamojo trakto dalies. Ieškojome ryšio tarp pakartotinio kraujavimo bei mirštamumo ir pacientų lyties, amžiaus, perpiltų kraujokomponentų vienetų, hospitalizacijos trukmės, laiko iki embolizacijos, atliktos embolizacijos rūšies (profilaktinė ar terapinė).RezultataiEmbolizacijos techninis efektyvumas buvo 100 %. Keturiolikai pacientų (70 %) buvo atlikta profilaktinė ir 6 (30 %) – terapinė embolizacija. Trims (15 %) pacientams po embolizacijos pasikartojo kraujavimas. Penki (25 %) pacientai mirė. Pacientams, kurie vėliau mirė, buvo perpilta statistiškai reikšmingai daugiau kraujo komponentų vienetų (šviežiai šaldytos plazmos p=0,04;eritrocitų masės p=0,01), jų hospitalizacija buvo ilgesnė (p=0,05). Statistiškai reikšmingų veiksnių, galinčių turėti įtakos pakartotinio kraujavimo dažniui, neradome.IšvadosTranskateterinė arterinė embolizacija yra tinkamas metodas po endoskopinio gydymo pasikartojusiam kraujavimui iš skrandžio ar dvylikapirštės žarnos opų gydyti. Nors šis būdas pasižymi dideliu techniniu ir klinikiniu efektyvumu ir mažu komplikacijų dažniu, tačiau reikalingi tolesni atsitiktinių imčių tyrimai šio gydymo būdo tinkamumui pagrįsti.
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Grimley, Daniel M. "Jean Sibelius, Solo Songs with Orchestra, opp. 3, 33, 70 and without opus number, edited by Kari Kilpeläinen and Timo Virtanen (Wiesbaden: Breitkopf & Härtel, 2003). 336pp. ∊178; Solo Songs with Piano, opp. 1,13, 17, 35–8, 50, 57, 61, 72, 86, 88, 90 edited by Jukka Tiilikainen (Wiesbaden: Breitkopf & Härtel, 1998, 2000). 240pp each. £127. [Jean Sibelius Complete Works, Series VIII, vols.1–3]." Nineteenth-Century Music Review 2, no. 2 (November 2005): 242–45. http://dx.doi.org/10.1017/s1479409800002494.
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Xie, Donghua, Yingchun Luo, Xiyue Xiong, Mingxing Lou, Zhiyu Liu, Aihua Wang, Lili Xiong, Fanjuan Kong, Yichao Wang, and Hua Wang. "Study on the Potential Biomarkers of Maternal Urine Metabolomics for Fetus with Congenital Heart Diseases Based on Modified Gas Chromatograph-Mass Spectrometer." BioMed Research International 2019 (May 6, 2019): 1–10. http://dx.doi.org/10.1155/2019/1905416.
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Background.There has been significant research on the genetic and environmental factors of congenital heart defects (CHDs), but few causes of teratogenicity, especially teratogenic mechanisms, can be clearly identified. Metabolomics has a potential advantage in researching the relationship between external factors and CHD.Objective.To find and identify the urinary potential biomarkers of pregnancy (including in the second and third trimesters) for fetuses with CHD based on modified gas chromatograph-mass spectrometer (GC-MS), which could reveal the possibility of high-risk factors for CHD and lay the foundation for early intervention, treatment, and prevention.Methods.Using a case-control design, we measured the urinary potential biomarkers of maternal urine metabolomics based on GC-MS in a population-based sample of women whose infants were diagnosed with CHD (70 case subjects) or were healthy (70 control subjects). SIMCA-P 13.0 software, principal component analysis (PCA), orthogonal partial least squares-discriminant analysis (OPLS-DA), Wilcoxon-Mann-Whitney test, and logistics regression were used to find significant potential biomarkers.Result.The 3D score graph of the OPLS-DA showed that the CHD and control groups were fully separated. The fitting parameters were R2x=0.78 and R2y=0.69, and the forecast rate was Q2=0.61, indicating a high forecast ability. According to the ranking of VIPs from the OPLS-DA models, we found 34 potential metabolic markers with a VIP > 1, and after two pairwise rank sum tests, we found 20 significant potential biomarkers, which were further used in multifactor logistic regressions. Significant substances, including 4-hydroxybenzeneacetic acid (OR=4.74, 95% CI: 1.06-21.06), 5-trimethylsilyloxy-n-valeric acid (OR=15.78, 95% CI: 2.33-106.67), propanedioic acid (OR=5.37, 95% CI: 1.87-15.45), hydracrylic acid (OR=6.23, 95% CI: 1.07-36.21), and uric acid (OR=5.23, 95% CI: 1.23-22.32), were associated with CHD.Conclusion.The major potential biomarkers in maternal urine associated with CHD were 4-hydroxybenzeneacetic acid, 5-trimethylsilyloxy-n-valeric acid, propanedioic acid, hydracrylic acid, and uric acid, respectively. These results indicated that the short chain fatty acids (SCFAs) and aromatic amino acid metabolism may be relevant with CHD.
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Abidin, Nur Husna Zainal, Wan Nazihah Wan Ibrahim, Nor Suhaila Mohamad Hanapi, and Nor’ashikin Saim. "Magnetic Mesoporous Silica Composite for Enhanced Preconcentration of Selected Organophosphorus Pesticides in Fruits." Indonesian Journal of Chemistry 20, no. 4 (June 10, 2020): 729. http://dx.doi.org/10.22146/ijc.42935.
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In the present work, MCM-41 coated magnetic particles (Fe3O4-MCM-41) composite was synthesized and employed as an effective adsorbent in magnetic solid phase extraction (MSPE) of three selected organophosphorus pesticides (OPPs) namely chlorpyrifos, diazinon and parathion methyl from grape and strawberry samples prior to high performance liquid chromatography with UV detection (HPLC-UV). The synthesized sorbent was physicochemically and morphologically characterized via Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and N2 adsorption analysis. The main parameters on the extraction efficiency of selected OPPs, including extraction time, desorption solvent, desorption time, and sorbent dosage, were thoroughly optimized. Compared to MCM-41 sorbent, the newly synthesized Fe3O4-MCM-41 adsorbent shows a linear response (0.1-5.00 mg L–1) with good determination coefficients ranging from 0.9900 to 0.9980, low limits detection (LODs), 0.02-0.15 mg L–1 and low limit quantifications (LOQs), 0.06-0.40 mg L–1. The precision as relative standard deviation (%RSD) of the proposed MSPE method was studied at low and high concentration (0.1-5.0 mg L–1) based on intra-day (1.0 to 6.0%, n = 3) and inter-day (1.0 to 7.0%, n = 3), respectively. Fruit matrices were used to assess the field applicability of the sorbents. Comparatively, Fe3O4-MCM-41 achieved excellent percent recovery (85–120%) compared to the MCM-41 (70–110%). The result revealed that the Fe3O4-MCM-41 composite was efficient sorbent with good capability for the preconcentration of selected OPPs from fruit samples.
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Проценко, Антон Сергеевич, and Роберт Мидхатович Сатаев. "НОВЫЕ МАТЕРИАЛЫ С СЕЛИЩА ЗИНИНО-1." Археология Евразийских степей, no. 2 (April 30, 2021): 250–60. http://dx.doi.org/10.24852/2587-6112.2021.2.250.260.
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Селище Зинино-1 – сезонная стоянка убаларского культурного типа кара-абызской археологической культуры. В статье обсуждаются результаты исследования керамического и археозоологического материала из раскопок памятника. Целью исследования являлось оценка степени влияния убаларского населения на хозяйственный уклад носителей кара-абызской культуры в целом. Коллекция керамического материала ярко иллюстрирует «симбиоз» населения Южного Приуралья на рубеже эр. Анализ примесей к формовочной массе сосудов позволило установить преобладание керамики убаларского типа, что подтверждает культурную атрибуцию селища. Убаларская керамика выделяется по плотной фактуре теста и высокому содержанию в нем песка. Среди индивидуальных находок присутствуют четыре фрагмента терочных плит, но их назначение остается неясным. Предположительно они не использовались при приготовлении пищи. Археозоологический материал немногочисленный. Концентрация костей в культурном слое невысокая, только в первом горизонте остатки животных встречены во всех квадратах. Несмотря на это, здесь были выявлены остатки животных, происходящие от пяти домашних и двух диких видов. По количеству костей лидирует крупный рогатый скот. Пересчет количества костей на объем мясной продукции дает основание говорить, что основой мясного рациона жителей селища являлась говядина и конина. В целом, рассмотренный материал не дает оснований говорить, что приход убаларского населения как-то существенно повлиял на хозяйственный уклад кара-абызских племен.
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Овсянников В.В. Естественнонаучные исследования культурного слоя поселений Прибелья эпохи раннего железа // XXI Уральское археологическое совещание, посвященное 85-летию со дня рождения Г.И. Матвеевой и 70-летию со дня рождения И.Б. Васильева. Материалы Всероссийской научной конференции с международным участием / Ред. А.А. Выборнов. Самара: СГСПУ, 2018. С. 232–234.
Овсянников В.В., Каюмов И.Х., Бабин И.М. Новые материалы с поселений кара-абызской культуры // УАВ. 2015. Вып. 15. С. 85–110.
Овсянников В.В., Савельев Н.С. Воинское святилище на Акбердинском II городище // Археология Евразийских степей. 2019. №2. С. 201–226.
Проценко А.С., Курманов Р.Г. Археолого-палинологические исследования культурного слоя городища Кара-Абыз // Вестник Ан РБ. 2019. Т. 33. № 4 (96). С. 62–71.
Проценко А.С., Сатаев Р.М. К вопросу об основах жизнеобеспечения носителей кара-абызской культуры // Вестник Томского государственного университета. История. 2016. №6 (44). С. 125–133.
Савельев Н.С. Керамические импорты кара-абызской культуры: их происхождение, контекст и датирующие возможности // Археология и палеоантропология евразийских степей и сопредельных территорий / МИАР. Вып. 13 / Отв. ред. М.М. Герасимова, В.Ю. Малашев, М.Г. Мошкова. М.: Таус, 2010. С. 295–318.
Савельев Н.С. Гафурийский керамический комплекс эпохи раннегожелеза с Биктимировского городища // РА. 2011. №2. С.56–66.
Савельев Н.С. О происхождении убаларского культурного типа в лесостепи Южного Приуралья // УАВ. 2017. №17. С. 18–38.
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Komoń, Michał. "Uszczelnienie zespolenia jelitowego po resekcji raka esicy z wykorzystaniem matrycy kolagenowej." Polish Journal of Surgery 92, no. 6 (December 31, 2020): 1–6. http://dx.doi.org/10.5604/01.3001.0014.5920.
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Wprowadzenie: Rak jelita grubego jest jednym z najczęstszych nowotworów złośliwych w populacji kraju. Leczeniem z wyboru jest leczenie operacyjne, które obarczone jest szeregiem powikłań, w tym nieszczelnością zespolenia jelitowego. Opis przypadku: 70-letni chory z rakiem esicy, po VATS lobektomii górnej prawej, ze zmianą o charakterze metastatycznym w zakresie płuca lewego, z licznymi obciążeniami kardiologicznymi i internistycznymi, został zakwalifikowany do sigmoidektomii. Wykonano zabieg resekcji esicy z pierwotnym odtworzeniem ciągłości przewodu pokarmowego, a miejsce zespolenia pokryto dodatkowo lekiem TachoSil. Przebieg pooperacyjny był niepowikłany, pomimo wysokiego ryzyka wystąpienia powikłań pooperacyjnych u opisywanego pacjenta. Matryca kolagenowo fibrynogenowa TachoSil może być stosowana z dobrym skutkiem jako wzmocnienie i podłoże do prawidłowego gojenia zespoleń jelitowych.
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Sabaleuskaya, Volga. "Удзел габрэяў у вытворчасці тытуню ў Гродзенскай губерні (другая палова XIX – пачатак ХХ стагоддзя)." Studia Białorutenistyczne 13 (December 30, 2019): 55. http://dx.doi.org/10.17951/sb.2019.13.55-70.
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<p class="Normalny1"><span>W II poł. XIX i na pocz. XX w. na terenie Białorusi miał miejsce szybki rozwój przemysłu i handlu, do którego w znacznej mierze przyczynili się Żydzi, stanowiący nie mniej niż 50% ludności miast i miasteczek. Mimo zainteresowania naukowców historią ekonomiczną dotąd nie podjęto próby opisu kwestii rozwoju na Białorusi przemysłu tytoniowego jako odrębnej gałęzi przemysłu oraz ustalenia roli, jaką odegrali w tym procesie żydowscy rzemieślnicy. Brak badań odnoszących się do wskazanych kwestii zadecydował o podjęciu niniejszej analizy, której celem było dokonanie charakterystyki bazy aktów prawnych dotyczących działalności tytoniowej, a także analiza dynamiki rozwoju należących do Żydów zakładów tytoniowych w guberni grodzieńskiej. Zastosowano zróżnicowane metody badania: metodę historyczną, metodę opisu i klasyfikacji, odwołujące się do chronologicznego opisu faktów oraz zasad historyzmu, które pozwoliły na analizę zjawisk historycznych w kontekście epoki. Rezultatem badania jest opis licznych źródeł archiwalnych z zakresu historii przemysłu na Białorusi w II poł. XIX i na pocz. XX w. Ustalono, że podstawę prawną dla rozwoju przemysłu tytoniowego stanowiły zarządzenia w sprawie stawek podatku akcyzowego z lat 1838–1901, które sprzyjały procesom monopolizacji oraz powstawaniu licznych, nielegalnych zakładów chałupniczych. W guberni grodzieńskiej Żydzi przeważali zarówno w legalnej, jak i nielegalnej strefie produkcji tytoniu. W II poł. XIX oraz na pocz. XX w. przemysł tytoniowy znacznie się rozwinął: wprowadzano w życie osiągnięcia naukowe, wykorzystywano nowe technologie, dokonano modernizacja produkcji. Dzięki przewadze technologicznej i organizacyjnej najsilniejszą pozycję posiadały duże przedsiębiorstwa. Ze względu na wysoką jakość i przystępną cenę wyroby tytoniowe pochodzące z guberni grodzieńskiej mogły konkurować z innymi. Wyroby te miały mocną pozycję na rynku rosyjskim.</span></p>
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Ali, Nadeem, Nabil A. Alhakamy, Iqbal M. I. Ismail, Ehtisham Nazar, Ahmed Saleh Summan, Syed Ali Musstjab Akbar Shah Eqani, and Govindan Malarvannan. "Exposure to Phthalate and Organophosphate Esters via Indoor Dust and PM10 Is a Cause of Concern for the Exposed Saudi Population." International Journal of Environmental Research and Public Health 18, no. 4 (February 22, 2021): 2125. http://dx.doi.org/10.3390/ijerph18042125.
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In this study, we measured the occurrence of organophosphate esters (OPEs) and phthalates in the settled dust (floor and air conditioner filter dust) and in suspended particulate matter (PM10) from different microenvironments (households (n = 20), offices (n = 10) and hotels (n = 10)) of Jeddah, Saudi Arabia. Bis (2-Ethylhexyl) phthalate (DEHP) was the major pollutant (contributing >85% of total chemicals burden) in all types of indoor dust with a concentration up to 3,901,500 ng g−1. While dibutyl phthalate (DBP) and DEHP together contributed >70% in PM10 (1900 ng m−3), which indicate PM10 as a significant source of exposure for DBP and DEHP in different Saudi indoor settings. Tris (1-chloro-2-propyl) phosphate (TCPP) was the major OPE in PM10 with a concentration of up to 185 ng m−3 and the occurrence of OPEs in indoor dust varied in studied indoor settings. The estimated daily intake (EDI) of studied chemicals via dust ingestion and inhalation of PM10 was below the reference dose (RfD) of individual chemicals. However, estimated incremental lifetime cancer risk (ILCR) with moderate risk (1.5 × 10−5) for Saudi adults and calculated hazardous index (HI) of >1 for Saudi children from DEHP showed a cause of concern to the local public health.
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Adamczak, Marcin. "O modernizmie wyczerpanym." Kwartalnik Filmowy, no. 113 (May 7, 2021): 248–55. http://dx.doi.org/10.36744/kf.475.
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Artykuł jest recenzją książki Miłosza Stelmacha Przeczucie końca. Modernizm, późność i polskie kino (2020). Recenzja zawiera opis struktury publikacji – jej część pierwsza stanowi refleksję nad modernizmem w kinie, a druga przynosi bogaty materiał historyczny związany z późnym modernizmem w kinie polskim lat 70. i 80. Recenzent wskazuje na dużą wagę przywiązywaną przez autora do zagadnień instytucjonalnych oraz na szczególnie oryginalne pomysły związane z uwzględnieniem podziału na centrum i peryferie w globalnej dystrybucji prestiżu i kapitału symbolicznego za pośrednictwem festiwali filmowych. Autor książki przekonująco wykorzystuje też Deleuzjańskie i Derridiańskie (hauntologia) koncepcje, aplikując je twórczo do rzeczywistości kina polskiego. Stelmach w wielu aspektach proponuje nowy język dyskusji o kinie polskim ostatnich dekad ubiegłego stulecia.
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Alam, Syed Benazir, and D'Ann Rochon. "Cucumber Necrosis Virus Recruits Cellular Heat Shock Protein 70 Homologs at Several Stages of Infection." Journal of Virology 90, no. 7 (December 30, 2015): 3302–17. http://dx.doi.org/10.1128/jvi.02833-15.
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ABSTRACTRNA viruses often depend on host factors for multiplication inside cells due to the constraints of their small genome size and limited coding capacity. One such factor that has been exploited by several plant and animal viruses is heat shock protein 70 (HSP70) family homologs which have been shown to play roles for different viruses in viral RNA replication, viral assembly, disassembly, and cell-to-cell movement. Using next generation sequence analysis, we reveal that several isoforms of Hsp70 and Hsc70 transcripts are induced to very high levels during cucumber necrosis virus (CNV) infection ofNicotiana benthamianaand that HSP70 proteins are also induced by at least 10-fold. We show that HSP70 family protein homologs are co-opted by CNV at several stages of infection. We have found that overexpression of Hsp70 or Hsc70 leads to enhanced CNV genomic RNA, coat protein (CP), and virion accumulation, whereas downregulation leads to a corresponding decrease. Hsc70-2 was found to increase solubility of CNV CPin vitroand to increase accumulation of CNV CP independently of viral RNA replication during coagroinfiltration inN. benthamiana. In addition, virus particle assembly into virus-like particles in CP agroinfiltrated plants was increased in the presence of Hsc70-2. HSP70 was found to increase the targeting of CNV CP to chloroplasts during infection, reinforcing the role of HSP70 in chloroplast targeting of host proteins. Hence, our findings have led to the discovery of a highly induced host factor that has been co-opted to play multiple roles during several stages of the CNV infection cycle.IMPORTANCEBecause of the small size of its RNA genome, CNV is dependent on interaction with host cellular components to successfully complete its multiplication cycle. We have found that CNV induces HSP70 family homologs to a high level during infection, possibly as a result of the host response to the high levels of CNV proteins that accumulate during infection. Moreover, we have found that CNV co-opts HSP70 family homologs to facilitate several aspects of the infection process such as viral RNA, coat protein and virus accumulation. Chloroplast targeting of the CNV CP is also facilitated, which may aid in CNV suppression of host defense responses. Several viruses have been shown to induce HSP70 during infection and others to utilize HSP70 for specific aspects of infection such as replication, assembly, and disassembly. We speculate that HSP70 may play multiple roles in the infection processes of many viruses.
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De Rosa, A., R. Di Palo, L. Attanasio, E. Monaco, G. Campanile, and B. Gasparrini. "89 OPEN PULLED STRAW VITRIFICATION FOR IN VITRO-PRODUCED BUFFALO (BUBALUS BUBALIS) EMBRYOS." Reproduction, Fertility and Development 18, no. 2 (2006): 153. http://dx.doi.org/10.1071/rdv18n2ab89.
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The aim of this study was to compare the efficiency of different combinations of cryoprotectants for vitrification of IVP buffalo (Bubalus bubalis) embryos at different developmental stages by the open pulled straw (OPS) method. In method A, we evaluated the vitrification and warming solutions previously used to vitrify buffalo embryos in French straws (Gasparrini et al. 2001 Theriogenology 55, 307). Embryos were equilibrated in 1.4 M glycerol for 5 min before being placed into 1.4 M glycerol + 3.6 M ethylene glycol (EG) for 5 min. Then, embryos were transferred into 3.4 M glycerol + 4.6 M EG for 25 s and loaded into the OPSs. For warming, OPSs were briefly immersed in a 0.5 M sucrose solution; the embryos were exposed to 0.25 M sucrose for 5 min before transfer to SOF medium for culture. In Method B, we examined the vitrification and warming solutions previously used for OPS vitrification of cattle embryos (Vajta et al. 1998 Mol. Reprod. Dev. 51, 53-58). Buffalo embryos were equilibrated in 7.5% EG + 7.5% dimethyl sulfoxide (DMSO) for 3 min before transfer into 16.5% EG + 16.5% DMSO and 0.5 M sucrose. After 25 s, they were loaded into the OPSs. For warming, embryos were recovered in a 0.25 M sucrose solution and transferred into a 0.15 M sucrose solution for 5 min before being placed in SOF medium. A total of 293 IVP buffalo embryos (eight replicates) were vitrified at Day 7 of culture (Day 0 = in vitro fertilization). Embryos were vitrified at the following developmental stages: early blastocyst (eBL, n = 26 and 34 with methods A and B, respectively), blastocyst (Bl, n = 31 and 35 for Methods A and B, respectively), expanded blastocyst (XBl, n = 29 and 38 for Methods A and B, respectively), and hatched blastocyst (HBl, n = 46 and 54 for Methods A and B, respectively). Embryo survival rate was determined as the percentage of vitrified-warmed embryos undergoing further development during a 24-h in vitro culture period. Differences between methods were analyzed by ANOVA following arcsine transformation of data. The overall embryo survival rate recorded at 24 h was not significantly different between Methods A and B (70% vs. 62%, respectively). Specifically, no differences were observed in embryos vitrified at the eBL (70% vs. 73%, A and B, respectively), Bl (69% vs. 70%, A and B, respectively), and HBl (46% vs. 36%, A and B, respectively) stages. In contrast, a significantly higher survival rate was recorded for XBl-stage embryos vitrified-warmed by Method A as compared to Method B (90% vs. 53%, respectively; P < 0.01). In Method A, survival rate of XBl was significantly higher than that of HBl (P < 0.05), but it was not different from that of eBl and Bl. Within Method B, the survival efficiency was similar for eBL, BL, and XBl, whereas survival rate of HBl was significantly lower (P < 0.05). In conclusion, although overall embryo survival in vitro was similar between methods, the combination of cryoprotectants used in Method A seemed more suitable for vitrification of IVP buffalo embryos at the XBl stage.
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Foe, Kurniawan, Gon Namkoong, Matthew Samson, Enas M. Younes, Ilho Nam, and Tarek M. Abdel-Fattah. "Stability of High Band Gap P3HT : PCBM Organic Solar Cells Using TiOxInterfacial Layer." International Journal of Photoenergy 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/784724.
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We fabricated a poly[3-hexylthiophene] (P3HT) and [6,6]-phenyl-C61-butyric acid methyl ester (PC61BM) organic photovoltaic cells (OPCs) using TiOxinterfacial layer. We performed optimization processes for P3HT : PC61BM with the TiOxlayer. We found that a solution based TiOxlayer coated at a spin speed of 3000 rpm improved the photon absorption of the active layer. An optimized TiOxlayer was also used as the interfacial layer to investigate the stability of P3HT : PC61BM OPC. After 70 days of storage, we observed that the short-circuit current density (JSC) dropped by 16.2%, fill factor (FF) dropped by 10.6%, and power conversion efficiency (PCE) dropped approximately by 25%, while the open-circuit voltage (VOC) remained relatively stable. We found that a solution based TiOxlayer synthesized using a sol-gel chemistry method was very effective in protecting the active layer from degradation.
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Harris, A. G., I. Sinitsina, and K. Messmer. "Validation of OPS imaging for microvascular measurements during isovolumic hemodilution and low hematocrits." American Journal of Physiology-Heart and Circulatory Physiology 282, no. 4 (April 1, 2002): H1502—H1509. http://dx.doi.org/10.1152/ajpheart.00475.2001.
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Orthogonal polarization spectral (OPS) imaging is a new technique that can be used to visualize the microcirculation with reflected light. It uses hemoglobin absorption to visualize the red blood cells (RBCs). Thus the method could fail at low hematocrit (Hct). The aim of this study was to validate OPS imaging for quantitative measurements of diameter and functional capillary density (FCD) under conditions of hemodilution of varying degrees to achieve a wide range of Hcts. The validation was performed in the dorsal skinfold chamber of nine awake Syrian golden hamsters. Measurements of vessel diameter and FCD were performed off-line using Cap-Image on video sequences captured using OPS imaging and standard intravital fluorescence microscopy at baseline, 85, 70, 55, and 40% of the initial Hct. For hemodilution, isovolumic exchange of blood for 6% Dextran 60 was performed. Bland-Altman plots for the vessel diameter and FCD show good agreement between the two methods for both parameters at all studied Hcts. As expected, there was a systematic bias of ∼4 μm in the diameter measurements since the RBC column was measured and not the intravascular diameter. In conclusion, OPS imaging can be used to measure diameter and FCD at a wide range of Hcts.
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Golubiewski, Mikołaj. "Disco imperiów. Czesław Miłosz i przyszłość kultury." Stan Rzeczy, no. 1(14) (April 1, 2018): 89–106. http://dx.doi.org/10.51196/srz.14.5.
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Artykuł skupia się na krytyce, której Czesław Miłosz poddaje rozrywkę imperialnych społeczeństw lat 70. XX wieku. Celem refleksji jest opis tego, jak doświadczenie imperiów jawi się w antropologicznym science fiction noblisty pt. Góry Parnasu, które ukazało się pośmiertnie w roku 2012 (pisane 1968–1972). Tekst nigdy niepublikowanej powieści zdawać by się mógł krytyką kapitalizmu amerykańskiego i rozruchów studenckich z okresu kontrkultury, lecz wiele fragmentów wskazuje także na sowiecką Rosję. Jego doświadczenie styku imperium i rozrywki zarówno w Polsce, jak i za granicą uwrażliwiło go na przecięcie się społecznej standaryzacji, nieludzkości nauki i religijnego zbawienia. Artykuł eksploruje to złożone równanie zawarte nie tylko w powieści, lecz także w innych pismach polskiego poety z lat 70. XX wieku, w których podobnie ujawniają się problemy kondycji ludzkiej. Choć Miłosz nie zdołał wypełnić popularnoliterackich zobowiązań gatunku, to jednak jego krytyka przyziemnej zabawy jest o wiele silniejsza w Górach Parnasu, niż w którymkolwiek z innych jego dzieł. W tej powieści Miłosz uznaje kulturę popularną za przegrany projekt, a antidotum proponowane ze strony państwa – za społeczną standaryzację. Rzucając swoją refleksję nad społeczeństwem w przyszłość, Miłosz wykorzystuje gatunek fantastyki naukowej, żeby przekazać wyobrażenie o rozwoju kultury. Tak użyte science fiction nie urzeczywistnia swojego potencjału znanego z kultury popularnej, jednak wciąż stanowi niezwykły prognostyk o przyszłości kultury, który wywodzi się z romantycznych źródeł wieszczenia o stanie społeczeństwa i wyobrażania sobie jego właściwej przyszłej tożsamości.
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NAZ, ZEHRA, SAADIA ANJUM,, and MEHDI RAZA. "SERUM PROSTATE SPECIFIC ANTIGEN (PSA);." Professional Medical Journal 20, no. 01 (December 10, 2012): 017–22. http://dx.doi.org/10.29309/tpmj/2013.20.01.581.
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ABSTRACT… Objective: To study correlation between age-linked serum prostate specific antigen (PSA) levels in normal subjects andpatients of benign prostatic hyperplasia (BPH) and carcinoma prostate (CaP). Data source: OPDs. Study design: Case-control study.Setting: SIUT; Karachi Study duration: Six months. Methodology: 250 subjects were enrolled for the study and 93 were finally selected(31 each, representing the normal, BPH and CaP groups). Subjects 40 years of age and above were included and those with any urinarytract disorder or those under treatment with 5-á-reductase inhibitors were excluded. Each group was divided into four sub-groups of ages40 – 49, 50 – 59, 60 – 69 and 70 and above years. AxSYM total PSA (tPSA) assay® was used for serum PSA estimation. Values wereexpressed as mean and standard error of mean and Fischer’s test, students’ t test and correlation coefficient were used to determinesignificance and for comparison of data. Results: There was a no significant difference in PSA levels in all age groups when normals werecompared with BPH cases. PSA levels were significant in normal as compared to CaP cases and BPH as compared to CaP. Conclusions:No significant correlation between age-linked serum PSA levels in normal subjects and patients of BPH and CaP could be established. Thestudy, however, found a trend of declining PSA levels at the age of 70 years and above.
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Patterson, Jeffrey, Xiaojian Shi, William Bresette, Ryan Eghlimi, Sarah Atlas, Kristin Farr, Sonia Vega-López, and Haiwei Gu. "A Metabolomic Analysis of the Sex-Dependent Hispanic Paradox." Metabolites 11, no. 8 (August 20, 2021): 552. http://dx.doi.org/10.3390/metabo11080552.
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In Mexican Americans, metabolic conditions, such as obesity and type 2 diabetes (T2DM), are not necessarily associated with an increase in mortality; this is the so-called Hispanic paradox. In this cross-sectional analysis, we used a metabolomic analysis to look at the mechanisms behind the Hispanic paradox. To do this, we examined dietary intake and body mass index (BMI; kg/m2) in men and women and their effects on serum metabolomic fingerprints in 70 Mexican Americans (26 men, 44 women). Although having different BMI values, the participants had many similar anthropometric and biochemical parameters, such as systolic and diastolic blood pressure, total cholesterol, and LDL cholesterol, which supported the paradox in these subjects. Plasma metabolomic phenotypes were measured using liquid chromatography tandem mass spectrometry (LC-MS/MS). A two-way ANOVA assessing sex, BMI, and the metabolome revealed 23 significant metabolites, such as 2-pyrrolidinone (p = 0.007), TMAO (p = 0.014), 2-aminoadipic acid (p = 0.019), and kynurenine (p = 0.032). Pathway and enrichment analyses discovered several significant metabolic pathways between men and women, including lysine degradation, tyrosine metabolism, and branch-chained amino acid (BCAA) degradation and biosynthesis. A log-transformed OPLS-DA model was employed and demonstrated a difference due to BMI in the metabolomes of both sexes. When stratified for caloric intake (<2200 kcal/d vs. >2200 kcal/d), a separate OPLS-DA model showed clear separation in men, while females remained relatively unchanged. After accounting for caloric intake and BMI status, the female metabolome showed substantial resistance to alteration. Therefore, we provide a better understanding of the Mexican-American metabolome, which may help demonstrate how this population—particularly women—possesses a longer life expectancy despite several comorbidities, and reveal the underlying mechanisms of the Hispanic paradox.
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Michalak, Bartosz. "Międzyrzecki Rejon Umocniony – w oczekiwaniu na adaptacje i modernizacje." Budownictwo i Architektura 17, no. 1 (April 20, 2018): 021–28. http://dx.doi.org/10.24358/bud-arch_18_171_03.
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Pomiędzy Wrocławiem a Krosnem Odrzańskim, w latach 1928 – 1944, zbudowano około 650 żelbetowych schronów bojowych i biernych. Na odcinku ok. 250 km wzniesiono zarówno niewielkie obiekty przeznaczone dla dwóch, trzech osób jak i obiekty mieszczące całe podziemne koszary. Ponadto stawiano betonowe zapory przeciwczołgowe, budowano tamy, zapory, przeprawy mostowe i inne betonowe konstrukcje. Ważnym odcinkiem tych umocnień wschodnich granic Niemiec był Międzyrzecki Rejon Umocniony (MRU), obecnie w województwie lubuskim. Od lat 70. XX w.obiekty te nie pełnią pierwotnych funkcji. Jest to jednak nadal jeden z największych systemów obronnych na świecie. Długość podziemnych korytarzy wynosi ponad 30 km. Przyroda z czasem wykorzystała te pomieszczenia jako naturalne siedlisko dla dziesiątków tysięcy nietoperzy. Niestety, wciąż nie ma konkretnego planu zmiany ich funkcji. Wykorzystanie tych budowli dla współczesnych celów będzie wymagało ogromnych środków finansowych ale przede wszystkim interesujących idei i odważnych projektów.W artykule przedstawiono historię oraz opis kompleksu a także propozycje adaptacji schronów na nowe cele. Istnieje kilka koncepcji a realizacja tych planów byłaby cenną inicjatywą związaną z ochroną tego wyjątkowego obszaru i znajdujących się na nim obiektów inżynierskich.
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Du, Yang, Wei-Wei Shi, Yong-Xing He, Yi-Hu Yang, Cong-Zhao Zhou, and Yuxing Chen. "Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC." Biochemical Journal 436, no. 2 (May 13, 2011): 283–89. http://dx.doi.org/10.1042/bj20102097.
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The compatible solute ABC (ATP-binding cassette) transporters are indispensable for acquiring a variety of compatible solutes under osmotic stress in Bacillus subtilis. The substrate-binding protein OpuCC (Opu is osmoprotectant uptake) of the ABC transporter OpuC can recognize a broad spectrum of compatible solutes, compared with its 70% sequence-identical paralogue OpuBC that can solely bind choline. To explore the structural basis of this difference of substrate specificity, we determined crystal structures of OpuCC in the apo-form and in complex with carnitine, glycine betaine, choline and ectoine respectively. OpuCC is composed of two α/β/α globular sandwich domains linked by two hinge regions, with a substrate-binding pocket located at the interdomain cleft. Upon substrate binding, the two domains shift towards each other to trap the substrate. Comparative structural analysis revealed a plastic pocket that fits various compatible solutes, which attributes the multiple-substrate binding property to OpuCC. This plasticity is a gain-of-function via a single-residue mutation of Thr94 in OpuCC compared with Asp96 in OpuBC.
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Thompson, Sharon, Ziyang Pan, Caitlyn Edwards, Ginger Reeser, Naiman Khan, and Hannah Holscher. "The Impact of Fresh Hass Avocado on the Fecal Metabolome Among Adults with Overweight and Obesity: A Randomized, Controlled Trial." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 1593. http://dx.doi.org/10.1093/cdn/nzaa062_050.
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Abstract Objectives Avocados are nutrient-rich fruits that have been recently linked to beneficial alterations to the gastrointestinal microbiota. However, previous research on shifts in the fecal metabolome with avocado intake has largely been conducted in in vitro or preclinical models and little is known about their metabolomic impact in human subjects. Methods Adult participants (n = 109) 25–45 years of age with BMI ≥ 25.0 kg/m2 were enrolled in an investigator-blinded, parallel arm, randomized, controlled trial. Participants consumed isocaloric meals with or without fresh Hass avocado once daily for 12-weeks and reported ≥ 80% meal consumption over the intervention period. Untargeted fecal metabolites were quantified in a subsample of participants (n = 48) using gas chromatography mass spectroscopy and were normalized by sample weight. Kruskal-Wallis tests and false discovery rate type I error correction were conducted and orthogonal partial least squares discriminant analysis (OPLS-DA) was used to predict treatment group by fecal metabolite concentrations (RStudio, version 3.6.2). Results A total of 292 metabolites were identified at intervention follow-up. Of these, three metabolites differed significantly between treatment groups. Fecal concentrations of lanosterol (P = 0.0004, q = 0.04) and the fatty alcohols hexadecanol (P = 0.001, q = 0.04) and octadecanol (P = 0.001, q = 0.04), were greater in the group consuming avocado as compared to control. Seventeen additional metabolites, including nine fecal lipids, two fat soluble vitamin derivatives, and three monosaccharides/disaccharides differed at P < 0.05 but did not meet the q < 0.05 threshold. Treatment group assignment was predicted correctly in 70% of cases (R2 = 72%, Q2 = 33%) using the trained OPLS-DA model. Conclusions Fresh Hass avocado intake increased fecal lipid and sterol concentrations among healthy adults with overweight and obesity, demonstrating diet-related modifications to the fecal metabolome. Funding Sources Support for this research was provided by the Hass Avocado Board, the USDA National Institute of Food and Agriculture, Hatch project 1009249, and the USDA National Institute of Food and Agriculture AFRI Predoctoral Fellowship, project 2018–07785.
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Rao, Vithala R., and Luis Eduardo Pilli. "Conjoint Analysis para Pesquisa de Marketing no Brasil." Revista Brasileira de Marketing 13, no. 4 (September 11, 2014): 25–38. http://dx.doi.org/10.5585/remark.v13i4.2707.
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Este artigo oferece uma reviso, de 1971 at a atualidade, dos mtodos de conjoint analysis que so abordagens de coleta de dados baseadas em preferncias ou escolhas declaradas pelos consumidores. Milhares de estudos foram realizados com o uso de conjoint analysis, desde a introduo do mtodo no incio da dcada de 70. Este conjunto de mtodos permite que os pesquisadores de mercado estudem trade-off entre os atributos de novos produtos, sendo til para vrias decises de marketing com design de produto, apreamento e segmentao de mercado. O conjunto atual de opes de conjoint analysis composto pela abordagem tradicional de preferncia declarada, pelas tcnicas de escolhas discretas (CBCA ou choice based conjoint analysis) que se baseiam em escolhas declaradas, pela abordagem autoexplicativa que usa elicitao direta de importncia de atributos e avaliao dos nveis dos atributos e pela abordagem adaptativa (ACA ou adaptive conjoint analysis) que implica em coleta de dados por etapas e adaptativa. Este artigo resume estes mtodos e seus desenvolvimentos recentes e apresenta uma aplicao no Mercado brasileiro. Dada a versatilidade do mtodo, existe um enorme potencial para a pesquisa de marketing no Brasil. Essencialmente, esta metodologia est viva e crescendo.
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Randhawa, Gurpreet Kaur, Navyug Raj Singh, Jaswant Rai, Gobindnoor Kaur, and Resham Kashyap. "A Critical Analysis of Claims and Their Authenticity in Indian Drug Promotional Advertisements." Advances in Medicine 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/469147.
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Introduction. Drug promotional advertisements (DPAs) form a major marketing technique of pharmaceutical companies for promoting their products and disseminating ambiguous drug information which can affect prescribing pattern of physicians. Drug information includes product characteristics, various marketing claims with references in support to increase its credibility and authenticity.Material and Methods. An observational study was carried out on fifty printed drug advertisement brochures which were collected from different OPDs of Guru Nanak Dev Hospital attached to Government Medical College, Amritsar, India. These advertisements were analyzed and claims were categorized into true, false, exaggerated, vague, and controversial on criteria as reported by Rohraa et al. (2006). References of DPAs in support of the claims were critically analyzed for their retrievability from web and validity pertaining to claims.Results. Out of 209 claims from 50 advertisements, only 46% were found to be true, 21% false, 16% vague, 7% exaggerated, and 10% controversial in nature. Out of 160 references given in support of claims, 49 (30%) of references were irretrievable. Out of 111 (70%) retrievable references, 92 (83%) references were found valid.Conclusion. Drug information provided in the DPAs was biased, incomplete, unauthentic, and unreliable with references exhibiting questionable credibility.
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De Oliveira, M., P. V. Alabarse, M. Farinon, R. Cavalheiro Do Espírito Santo, and R. Xavier. "AB0185 PROSPECTIVE PROFILE OF URINE METABOLOME IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1392.2–1392. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4481.
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Background:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality and associated with metabolic disorders. Since the metabolomic profile is known to vary in response to different inflammatory conditions, metabolome analysis could substantially improve diagnosis and prognosis of RA.Objectives:To analyze the urine metabolome profile in RA patients and correlate it with disease activity changes over 12 monthsMethods:Seventy-nine RA patients, according to ACR/EULAR 2010 classification criteria, between 40 and 70 years old, were recruited and followed for 12 months. Metabolome analysis was performed by Nuclear Magnetic Resonance spectroscopy (NMR), resulting in the identification of 93 metabolites in urine collected at the baseline and after 12 months. Frequency analysis, Pearson Correlation and Multivariate data analysis with orthogonal projections to latent structures (OPLS) method were performed and a statistical significance was considered as p<0.05.Results:The study population was characterized by the majority of women (86.7%), mean age of 56 years old, around 80% with positive anti-CCP or Rheumatoid Factor. During the one year of follow-up, there was no substantial variation in the DAS28 measurement (baseline: 3.8, after 12 months: 4.0). There was no significant correlation between the metabolome pattern and DAS28 score (p>0.05) over time. However, multivariate analysis (OPLS-DA) demonstrated an adequate differentiation of the population with 0.92 of accuracy (Q2: 0.72 and R2: 0.89).There was a significant increase of L-cysteine, choline, L-Phenylalanin, creatine, L-histidine, oxalacetic acid and xanthine, and a decrease of L-threonine, taurine, butyric and gluconic acid (p<0.05) during the follow-up, metabolites that are involved in the skeletal muscle metabolism.Conclusion:The observed biomarkers indicate,as expected, that the RA metabolic profile is associated with inflammation injury and skeletal muscle amino acid metabolism. Correlations with disease activity changes was compromised by the stable disease status during the 12 months. More studies evaluating correlations with skeletal muscle function and mass are underway.Acknowledgments:Disclosure of interest: Marianne Oliveira: None declared, Rafaela Santo: None declared, Mirian Farinon: None declared, Ricardo Xavier Consultant of: Abbvie, Pfizer, Novartis, Janssen, Lilly, RocheDisclosure of Interests:Marianne de Oliveira: None declared, Paulo Vinicius Alabarse: None declared, Mirian Farinon: None declared, Rafaela Cavalheiro do Espírito Santo: None declared, Ricardo Xavier Consultant of: AbbVie, Pfizer, Novartis, Janssen, Eli Lilly, Roche
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Kshatri, J. S., Nivedita Karmee, Sithun Kumar Patro, and R. M. Tripathy. "Patient satisfaction and out-patient services assessment in a tertiary hospital of South Odisha, India." International Journal of Advances in Medicine 4, no. 2 (March 23, 2017): 497. http://dx.doi.org/10.18203/2349-3933.ijam20171049.
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Background: The out-patient department of a hospital is for patients who do not require hospitalization but have come for their health needs, either for treatment or for diagnosis. The main objective of the study was to measure the satisfaction levels of the patients attending the OPDs of MKCG medical college.Methods: Data were collected from OPD patients through pre-structured questionnaires in the local languages at the OPD of MKCG Medical College. The data were analysed using SPSS.Results: Out of total 100 patients interviewed, 58 were males and 42 were females. 13% respondents were "highly unsatisfied" with the OPD services where as 65% were "unsatisfied", 15% were "satisfied" and only 7% "highly satisfied". 27% of the participants were from lower socio-economic status (SES), 70% were from middle class and the rest from upper class. 100% of those belonging to upper SES, 80% of middle SES and 70% of lower SES were highly unsatisfied or unsatisfied with OPD services. Most of the patients had come to attend the departments of Medicine (25%), Paediatrics (18%), Surgery (16%) and Obstetrics and Gynaecology (15%). 45% patients were visiting this facility for the first time. 11% of these new patients were Highly satisfied with the services while 31% of repeat patients were either satisfied or highly satisfied. The median waiting time between arrival and consultation was 1 hour. 84% participants had to incur out of pocket expenses. The mean amount spent was Rs. 350. 80% of those who had spent were of the opinion that they had to spend more than what was reasonable.Conclusions: Patient satisfaction was significantly associated with SES, repeat visits, and waiting time between arrival and consultation. Measures to reduce out of pocket expenditure and waiting time may increase satisfaction levels in patients.
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Gunawan, Gunawan, Junus Widjaja, Phetisya Pamela Frederika Sumolang, and Hayani Anastasia. "Cross-Sectoral Engagement in the Eradication of Schistosomiasis in Indonesia." Global Journal of Health Science 13, no. 10 (September 13, 2021): 82. http://dx.doi.org/10.5539/gjhs.v13n10p82.
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BACKGROUND: Indonesia has planned a roadmap to eradicate schistosomiasis and achieved the elimination of schistosomiasis by 2025. Through cooperation between the Ministry of Health and the Ministry of National Development Planning or the National Development Planning Agency (Bappenas). The roadmap is a reference to plan the shared action multiple sectors, central-regional and communal coordinated by the National Development Planning Agency (Bappenas) and Development Planning Agency at Sub-national Level (Bappeda).
OBJECTIVE: analyzing cross-sectoral involvement in 2019 in efforts to eradicate schistosomiasis. The research method is to analyze data and information regarding the schistosomiasis control program in 2019.
MATERIAL AND METHODS: The data and information in the study came from six Regional Apparatus Organizations (OPD) in Poso and seven OPDs in Sigi Central Sulawesi.
RESULT: This study reveals that, based on the roadmap to eradicate schistosomiasis, mass treatment regarding schistosomiasis for humans is 70-94%; mass medication for livestock is 50%; surveillance on intermediate snails, humans, and animals is 70-94%; 6,000 animals and 49%; the campaigns for behavioral changes and an increase in community participation in 18 villages and multi-sector coordination and intensive integrated supervision is 50%. Meanwhile, public toilets in the focus areas and livestock management have not proceeded. The prevalence of schistosomiasis in humans showed yields of 0.13%, 0%, and 0.0% in the Napu, Bada, and Lindu Plateaus. In addition, the prevalence of schistosomiasis in animals was 3.4% and 2.3% in buffalo and horses.
CONCLUSION: Schistosomiasis control in terms of health can reduce the prevalence of schistosomiasis in humans. And schistosomiasis control is not a priority program in terms of agriculture. Who did not build schistosomiasis control programs in 2019 upon good coordination between the central and local governments?
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Al Wutayd, Osama, Abdullah Al Nafeesah, Ishag Adam, and Ibrahim Babikir. "The antibiotic susceptibility patterns of uropathogens isolated in Qassim, Saudi Arabia." Journal of Infection in Developing Countries 12, no. 11 (November 30, 2018): 946–52. http://dx.doi.org/10.3855/jidc.10553.
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Introduction: Antimicrobial resistance is a global health problem. The present study was carried out to determine the prevalence and antibiotic resistance of uropathogens in the outpatient departments (OPDs) at the clinics of Qassim University, Saudi Arabia.
Methods: A cross-sectional study was conducted from January to December 2016. Nonrepetitive midstream urine samples (1273) were cultured on standard culture media. Identification and susceptibility testing of causative microorganisms was performed using the fully automated VITEK 2 Compact system.
Results: Out of the 1273 nonrepetitive urine samples, 418 (32.8%) exhibited significant growth of UTI-causing microbes, 377 (90.2%) of which were Gram-negative bacilli. The commonly isolated microorganisms were Escherichia coli (157, 37.6%), Klebsiella pneumoniae (70, 16.7%), Proteus mirabilis (17, 4.1%), Pseudomonas aeruginosa (24, 5.8%), Enterobacter cloacae (11, 2.6%), Enterococcus faecalis (12, 2.9%), and Staphylococcus aureus (14, 3.3%). Overall, drug resistance was observed in 91.3% (n=381/418) of the samples, with a majority (80%) exhibiting resistance to at least 2 drugs. Drug resistance was commonly observed against ampicillin (89.9%), oxacillin (75.6%), piperacillin (85.4%), clindamycin (56.1%), amoxicillin/clavulanic acid (74.5%) and trimethoprim/sulfamethoxazole (50.4%).
Conclusion: The uropathogens E. coli, K. pneumoniae and P. aeruginosa and multidrug resistance pose serious therapeutic threats in the setting of this study. A concerted and systematic effort is required to rapidly identify high-risk patients and to reduce the burden of antimicrobial resistance in this region.
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Fatima, Anum, Nadia Saif, Mansoor Ghani, and Sardar Ali. "KNOWLEDGE OF WOMEN." Professional Medical Journal 23, no. 07 (July 10, 2016): 828–34. http://dx.doi.org/10.29309/tpmj/2016.23.07.1648.
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Objectives: Around 50 to 70% of the neural tube defects can be prevented if awoman consumes sufficient folic acid daily before conception and throughout first trimester ofher pregnancy. Therefore, the women should be well aware about the apt supplementation offolic acid to mitigate those miseries that can be resulted from its deficiency. Study Design: Adescriptive survey design. Setting: Obstetrical OPDs of Lahore General Hospital, Lady AitchisonHospital, Jinnah Hospital Lahore, DHQ Hospital Multan, DHQ Hospital Faisalabad, and DHQHospital Rawalpindi. Methodology: A total of 300 pregnant women were studied to assess thelevel of knowledge and practices among women regarding use of folic acid before and duringpregnancy. Non probability convenient sampling technique was used for the purpose. Data wascollected by a self administered questionnaire and was analysed by SPSS version 20. A p-valueof ≤ 0.05 was considered statistically significant. Results: The results signified that a majorfraction of pregnant women 227 (76%) were having poor level of knowledge as they scoredless than 50% on knowledge based questions in the questionnaire. Only 4% were distinguishedwith excellent knowledge according to arbitrary scale, which were made-up to be a very lowpercentage. Conclusion: Findings of the study suggested that the knowledge of the womenregarding folic acid supplementation is insufficient that may in response lead to increase risk forthe incidences of neural tube defect.
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Krasniqi, Eriseld, Maddalena Barba, Aldo Venuti, Laura Pizzuti, Federico Cappuzzo, Lorenza Landi, Silvia Carpano, et al. "Circulating HPV DNA in the Management of Oropharyngeal and Cervical Cancers: Current Knowledge and Future Perspectives." Journal of Clinical Medicine 10, no. 7 (April 6, 2021): 1525. http://dx.doi.org/10.3390/jcm10071525.
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Human papillomaviruses (HPVs) are associated with invasive malignancies, including almost 100% of cervical cancers (CECs), and 35–70% of oropharyngeal cancers (OPCs). HPV infection leads to clinical implications in related tumors by determining better prognosis and predicting treatment response, especially in OPC. Currently, specific and minimally invasive tests allow for detecting HPV-related cancer at an early phase, informing more appropriately therapeutical decisions, and allowing for timely disease monitoring. A blood-based biomarker detectable in liquid biopsy represents an ideal candidate, and the use of circulating HPV DNA (ct-DNA) itself could offer the highest specificity for such a scope. Circulating HPV DNA is detectable in the greatest part of patients affected by HPV-related cancers, and studies have demonstrated its potential usefulness for CEC and OPC clinical management. Unfortunately, when using conventional polymerase chain reaction (PCR), the detection rate of serum HPV DNA is low. Innovative techniques such as droplet-based digital PCR and next generation sequencing are becoming increasingly available for the purpose of boosting HPV ct-DNA detection rate. We herein review and critically discuss the most recent and representative literature, concerning the role of HPV ctDNA in OPC and CEC in the light of new technologies that could improve the potential of this biomarker in fulfilling many of the unmet needs in the clinical management of OPC and CEC patients.
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Renjhen, Prachi, Vikas Kumar, Akanksha Rathi, and Attuluri Loukya. "Contraceptive practices and awareness about emergency contraception among women attending a tertiary care hospital of Delhi, India." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 3 (February 26, 2019): 1047. http://dx.doi.org/10.18203/2320-1770.ijrcog20190878.
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Background: Emergency contraceptive pills (ECs) are a safe female-controlled method of post-coital contraception; however, the knowledge about them is low among general population.Methods: This cross-sectional study was done among the adult females, aged 18 years and above, who visited the various out-patient departments (OPD) of a tertiary care hospital in July 2017. A total of 640 adult females, who visited the OPDs of medicine, surgery, orthopedics and gynecology were included in this study. Data were entered and analyzed using SPSS ver 16. Chi-square test was used to test association. A p-value of less than 0.05 was considered as significant association.Results: Of the 640 participants, mostly were Hindu, aged between 20-29 years, married and had more than one child. Only, 52% females were aware of the term ‘contraception’ and 17.7% about ‘emergency contraception’. The only method of ECs they were aware of was i-pill. Commonest source of their knowledge was friends, relatives and spouse. Only 70 women knew that it can be used after unprotected intercourse and 25 knew that it can be used after failure of barrier method. Just 41.2% women used any kind of contraceptive and 5.3% women have ever used an EC. Around 28% women reported not using contraception due to lack of knowledge.Conclusions: Despite of their availability since many years, awareness about emergency contraception is low. More efforts are required to generate awareness about regular use of effective contraception and emergency contraception if required.
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SANTOS, JAKELINE MARIA DOS, SÔNIA MARIA FORTI BROGLIO, JÚLIO MARCOS MELGES WALDER, DJISON SILVESTRE DOS SANTOS, and THIAGO RAMOS SILVA. "INTERSPECIFIC COMPETITION BETWEEN NATIVE AND EXOTIC FRUIT FLY PARASITOIDSIN MIXED ORCHARDS IN MACEIO, ALAGOAS, BRAZIL." Revista Caatinga 29, no. 4 (December 2016): 901–9. http://dx.doi.org/10.1590/1983-21252016v29n415rc.
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ABSTRACT The objective of this work was to assess the effects of the release and establishment of the exotic parasitoid Diachasmimorpha longicaudata (Ashmead, 1905) (Hymenoptera: Braconidae) and its interspecific competitive relationship with native fruit fly parasitoids in organic and conventional orchards in Maceio, State of Alagoas, Brazil. The exotic parasitoids were reared in the Radio-Entomology Laboratory of the Center for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, São Paulo, and released (112,350 individuals between five and eight days old) in orchards from June 8 to July12, 2013.Fruit samples were collected randomly every week during one year to assess the D. longicaudata recaptured from plants and fallen fruits on the ground, which were taken to the Entomology Laboratory of the CECA-UFAL, classified and individually placed in plastic containers, containing a layer of 1 cm of sand for pupation of the host larvae. The pupae, obtained after 10 days, were placed in Petri dishes with a layer of sand until the emergence of adults, which were then kept in plastic microtubes, containing ethanol 70%. The release of exotic parasitoids did not displace native species. The same species were found before and after the release in both cultures: Doryctobracon areolatus, Asobara anastrephae, Utetes anastrephae and Opius bellus (Braconidae), Aganaspis pelleranoi (Figitidae) and individuals of the Pteromalidae family. One year after the last release, 44 individuals of the exotic parasitoid were found, showing its establishment in the studied areas.