Relevant bibliographies by topics / OR GHX

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'OR GHX'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "OR GHX"

1

Bae, Sang Mu, Yujin Nam, and Byoung Ohan Shim. "Feasibility Study of Ground Source Heat Pump System Considering Underground Thermal Properties." Energies 11, no. 7 (July 10, 2018): 1786. http://dx.doi.org/10.3390/en11071786.

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: A typical ground source heat pump (GSHP) system in South Korea has a ground heat exchanger (GHX) with a length of 100–150 m, which utilizes annually stable underground temperature to meet the loads of cooling, heating and hot water in buildings. However, most GSHP systems have been introduced in heating dominated areas because the system performance advantage is larger compared with air source heat pump system than that in cooling dominated areas. To effectively provide geothermal energy to the building in the limited urban area, it is necessary to install deep GHXs. Despite its large capacity, there are few studies on GSHP system with deep GHX over 300 m. In this study, to estimate the performance of the GSHP system with deep GHX and evaluate its feasibility, numerical simulation was conducted. To quantitatively analyze heat transfer between soil and GHX, the coupled model with GHX model and ground heat and groundwater transfer model was used. Furthermore, the heat exchange rate and the source temperature were calculated according to the operation modes, the length of GHX, and soil conditions such as geothermal gradient and thermal conductivity. As a result, the total heat exchange rate of GHX with a length of 300 m heat exchanger was 12.62 kW, 173% that of a length of 150 m. Finally, it was found that the GSHP system with deep GHX has realistic possibility in good condition of geothermal gradient.
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Kim, Kwonye, Jaemin Kim, Yujin Nam, Euyjoon Lee, Eunchul Kang, and Evgueniy Entchev. "Analysis of Heat Exchange Rate for Low-Depth Modular Ground Heat Exchanger through Real-Scale Experiment." Energies 14, no. 7 (March 29, 2021): 1893. http://dx.doi.org/10.3390/en14071893.

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A ground source heat pump system is a high-performance technology used for maintaining a stable underground temperature all year-round. However, the high costs for installation, such as for boring and drilling, is a drawback that prevents the system to be rapidly introduced into the market. This study proposes a modular ground heat exchanger (GHX) that can compensate for the disadvantages (such as high-boring/drilling costs) of the conventional vertical GHX. Through a real-scale experiment, a modular GHX was manufactured and buried at a depth of 4 m below ground level; the heat exchange rate and the change in underground temperatures during the GHX operation were tracked and calculated. The average heat exchanges rate was 78.98 W/m and 88.83 W/m during heating and cooling periods, respectively; the underground temperature decreased by 1.2 °C during heat extraction and increased by 4.4 °C during heat emission, with the heat pump (HP) working. The study showed that the modular GHX is a cost-effective alternative to the vertical GHX; further research is needed for application to actual small buildings.
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Oh, Hyunjun, and James M. Tinjum. "Modeling of shallow, horizontal, unsaturated, ground-based heat exchangers with consideration of dry zone formation." E3S Web of Conferences 205 (2020): 07005. http://dx.doi.org/10.1051/e3sconf/202020507005.

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High fluid temperatures in ground-based heat exchangers (GHXs) during the cooling season may result in a decrease in thermal conductivity of adjacent backfill (λbackfill), potentially causing degradation in the performance efficiency of the GHX system. In this study, numerical modeling was performed using the SVOffice™ finite-element software to evaluate coupled heat and moisture transfer around two GHXs. Constant-temperature boundary conditions of 35 ºC were applied to the GHX surfaces, and thermal properties of the backfill were controlled for comparisons. For estimate typical hydraulic and thermal properties for the modeling, laboratory tests and literature review were performed. Modeling results indicate that coupled heat and moisture transfer occurs rapidly near the GHX involving a dry zone formation when λbackfill decreases. A boundary between dry and wet zones where soil thermal properties rapidly change was observed around 50% GHX temperature dissipated (T50), and accordingly T50 was used to optimize the pipe configuration. Coupled heat and moisture transfer increased when the GHX configurations were optimized with consideration of dry zone formation. These results imply that thermally enhanced, engineered backfill and optimized configurations can enhance GHX system efficiency.
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Oh, Hyunjun, and James M. Tinjum. "Simplified two-step, cross-sectional approach for coupled heat and moisture transfer modeling of shallow, horizontal, ground-based heat Exchangers." E3S Web of Conferences 205 (2020): 07004. http://dx.doi.org/10.1051/e3sconf/202020507004.

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This study evaluates a two-step, cross-sectional approach for designing shallow, unsaturated, horizontal, ground-based heat exchangers (GHXs). Numerical modeling was conducted for coupled heat and moisture transfer around GHXs under transient climatological conditions through a cooling season. Soil samples were collected in Texas and Wisconsin to measure thermal conductivity dry-out curves and soil-water characteristic curves for use in the modeling. Average daily meteorological data from central Texas was applied for the top boundary condition. Heat generation from the GHX was calculated by total condenser heat rejection from an environmental control unit based on ambient temperatures and unit specifications. In the first step of the modeling, results showed that the fluid temperature through the GHX loop was approximately 43 ºC, and rapid heat and moisture fluxes were observed around the GHX loops. High moisture flux along the upper surface was also observed due to high ambient temperatures that occur during the summer season. Using these results, exiting temperature of the GHX was estimated for the second cross-sectional modeling step. This two-step, cross-sectional modeling approach provides a systematic analysis of coupled heat and moisture transfer around shallow, horizontal, unsaturated GHX loops, thus simplifying high computational effort needed for full three-dimensional modeling of shallow GHX systems.
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Bae, Sang, Yujin Nam, Jong Choi, Kwang Lee, and Jae Choi. "Analysis on Thermal Performance of Ground Heat Exchanger According to Design Type Based on Thermal Response Test." Energies 12, no. 4 (February 18, 2019): 651. http://dx.doi.org/10.3390/en12040651.

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A ground source heat pump (GSHP) system has higher performance than air source heat pump system due to the use of more efficient ground heat source. However, the GSHP system performance depends on ground thermal properties and groundwater conditions. There are many studies on the improvement of GSHP system by developing ground heat exchanger (GHX) and heat exchange method. Several studies have suggested methods to improve heat exchange rate for the development of GHX. However, few real-scale experimental studies have quantitatively analyzed their performance using the same ground conditions. Therefore, the objective of this study was to evaluate the thermal performance of various pipe types of GHX by the thermal response test (TRT) under the same field and test conditions. Four kinds of GHX (HDPE type, HDPE-nano type, spiral fin type, and coaxial type) were constructed in the same site. Inlet and outlet temperatures of GHXs and effective thermal conductivity were measured through the TRT. In addition, the borehole thermal resistance was calculated to comparatively analyze the correlation of the heat exchange performance with each GHX. Result of the TRT revealed that averages effective thermal conductivities of HDPE type, HDPE-nano, spiral fin type, and coaxial type GHX were 2.25 W/m·K, 2.34 W/m·K, 2.55 W/m·K, and 2.16 W/m·K, respectively. In the result, it was found that the average borehole thermal resistance can be an important factor in TRT, but the effect of increased thermal conductivity of pipe material itself was not significant.
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Ratnasari, Agnes, Efri Efri, Muhammad Syamsoel Hadi, and Hasriadi Mat Akin. "KETAHANAN BEBERAPA GENOTIPE SORGUM (Sorghum bicolor [L]Moench) TERHADAP PENYAKIT ANTRAKNOSA (Colletotrichum graminicola) PADA DUA SISTEM POLA TANAM BERBEDA." Jurnal Agrotek Tropika 7, no. 2 (May 3, 2019): 351. http://dx.doi.org/10.23960/jat.v7i2.3258.

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Tujuan penelitian ini yaitu mengetahui ketahanan 15 genotipe sorgum yang ditanam pada dua sistem tanam berbeda yaitu monokultur dan tumpangsari. Penelitian ini dilaksanakan pada bulan April 2017- Februari 2018 di Desa Sukanegara, Kecamatan Tanjung Bintang, Kabupaten Lampung Selatan, Lampung dan di Laboratorium Hama dan Penyakit Tanaman Fakultas Pertanian Universitas Lampung. Perlakuan disusunmenggunakan rancangan acak kekompok dalam Split Plot Design dengan faktor utama adalah sistem pola tanam (tumpangsari, monokultur), dan anak petak adalah 15 genotipe sorgum (Numbu, Samurai 1, GH3, UPCA, GH4, P/I WHP, GH6, Super 2, GH13, P/F 51-93-C, Super 1, GH5, Mandau, GH7 dan TalagaBodas). Monokultur sorgum ditanam pada jarak 80 cm x 20 cm. Tumpangsari sorgum ubikayu dilakukan dengan cara menanam sorgum di antara tanaman ubikayusehingga jarak tanam sorgum tetap 80 cm x 20 cm, sedangkan jarak tanam ubikayu 80 cm x 60 cm, baik sorgum maupun ubikayu ditanam secara bersamaan. Hasil penelitian menunjukkan bahwa sistem tanam tumpangsari lebih efektif untuk menekan intensitas penyakit antraknosa. Pada penelitian ini intensitas penyakit antraknosa terhadap 15 genotipe sorgum yang diamati dikelompokan menjadi 3 kategori yaitu tinggi, sedang dan rendah. Genotipe Numbu, GH3, Talaga Bodas, Super 1, dan Mandau adalah genotipe dengan intensitas penyaki terendah dibandingkan genotipe Samurai 1, UPCA, GH4, P/I WHP, GH13, P/F 5-193-C, GH5, GH6 dan GH7 . Genotipe Samurai 1, UPCA, GH4, P/I WHP, GH13, P/F 5-193-C, GH5, GH6 dan GH7 adalah genotipe yang intensitas penyakitnya lebih rendah dibandingkan genotipe Super 2. Dan genotipe Super 2 adalah genotipe dengan intnsitas penyakit antraknosa tertinggi.
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Kim, Jaemin, and Yujin Nam. "Development of the Performance Prediction Equation for a Modular Ground Heat Exchanger." Energies 13, no. 22 (November 17, 2020): 6005. http://dx.doi.org/10.3390/en13226005.

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Although ground source heat pump (GSHP) systems are more efficient than conventional air source heat pump (ASHP) systems, their high initial investment cost makes it difficult to introduce them into small buildings. Therefore, the development of a method for reducing the installation costs of GSHPs for small buildings is essential. This study proposes a modular ground heat exchanger (GHX) for cost reduction and an improved workability of GSHPs. In addition, a numerical model was constructed for the analysis of the performance of the modular GHX. However, to easily introduce the new GHX at the building design stage, the development of a performance prediction method for the introduction of modular GHXs to small buildings is necessary. Therefore, the entering water temperature (EWT) equation was derived from the calculation methods in the heat transfer process, and the ground temperature model was developed in consideration of the operation condition. The numerical results showed that the average values of EWT and ground temperature were 8.11 °C and 8.00 °C, respectively under an average ambient temperature of 0.42 °C. In addition, the performance prediction model was compared with the numerical results. The results showed that the coefficient of variation of the root mean square error (RMSE) of the ground temperature and EWT model were 5.20% and 1.33%, respectively.
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Chang, Keun Sun, Min Jun Kim, and Young Jae Kim. "An Experimental Study on the Thermal Performance Evaluation of SCW Ground Heat Exchanger." International Journal of Air-Conditioning and Refrigeration 25, no. 01 (March 2017): 1750006. http://dx.doi.org/10.1142/s2010132517500067.

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In recent years, application of the standing column well (SCW) ground heat exchanger (GHX) has been noticeably increased as a heat transfer mechanism of ground source heat pump (GSHP) systems with its high heat capacity and efficiency. Determination of the ground thermal properties is an important task for sizing and estimating cost of the GHX. In this study, an in situ thermal response test (TRT) is applied to the thermal performance evaluation of SCW. Two SCWs with different design configurations are installed in sequence to evaluate their effects on the thermal performance of SCW using a single borehole. A line source method is used to derive the effective thermal conductivity and borehole thermal resistance. Effects of operating parameters are also investigated including bleed, heat injection rate, flow rate and filler height. Results show that the effective thermal conductivity of top drawn SCW (Type A) is 11.7% higher than that of bottom drawn SCW (Type B) and of operating parameters tested bleed is the most significant one for the improvement of the thermal performance (40.4% enhanced in thermal conductivity with 10.9% bleed).
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Muli, Farastika Unjunan, Efri Efri, Muhammad Syamsoel Hadi, and Radix Suharjo. "PENGARUH PENAMBAHAN PUPUK MIKRO DAN BEBERAPA GENOTIPE SORGUM (Sorghum bicolor (L.) Moench) TERHADAP INTENSITAS PENYAKIT ANTRAKNOSA (Colletotrichum sp.) DI LAHAN PETANI TANJUNG BINTANG LAMPUNG SELATAN." Jurnal Agrotek Tropika 8, no. 2 (May 20, 2020): 347. http://dx.doi.org/10.23960/jat.v8i2.3902.

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One of the diseases that often found in sorghum plants is anthracnose disease caused by Colletotrichum sp. The purposed of this study was to determine the effect of adding micro fertilizer and the use of several sorghum genotypes on the intensity of anthracnose disease. The study was conducted in Sukanegara, Tanjung Bintang, South Lampung in April 2017 - February 2018 and at the Laboratory of Plant Diseases and Pests, Faculty of Agriculture, University of Lampung. The treatments were arranged using a randomized block design in a split plot design (3 times replications), the main plot was micro nutrients (with micro addition and without micro addition) and 15 subgroups of sorghum genotypes (Numbu, Samurai 1, GH3, UPCA, GH4, P / I WHP, GH6, Super 2, GH13, P / F 51-93-C, Super 1, GH5, Mandau, GH7, and Talaga Bodas). The results showed that the addition of "ZincMicro" micro fertilizers to sorghum plants did not affect the intensity of anthracnose disease, however there were differences in the intensity of anthracnose diseases between sorghum genotypes. Numbu Genotype, GH 3, and GH 13 were relatively more resistant to anthracnose disease than the other genotypes.
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Mattiuzzi, Camilla, and Giuseppe Lippi. "Cancer statistics: a comparison between World Health Organization (WHO) and Global Burden of Disease (GBD)." European Journal of Public Health 30, no. 5 (November 25, 2019): 1026–27. http://dx.doi.org/10.1093/eurpub/ckz216.

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Abstract This study aims to define comparability of 2016 statistics between Global Health Estimates (GHE) and Global Health Data Exchange (GHDx) registries for disability-adjusted life years (DALYs) and mortality of the 25 most frequent worldwide malignancies. An excellent correlation can be found between the two registries for both cancer DALYs (r = 0.988) and mortality (r = 0.993). Cancer-related DALYs are substantially equivalent (mean bias, −1.9%; P = 0.603), while cancer mortality is modestly but significantly overestimated in GDHx (mean bias, 9.1%; P = 0.004). These results suggest that cancer DALYs estimate appear almost overlapping between GHE and GHDx registries, while cancer mortality is slightly overestimated in GDHx.
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Dissertations / Theses on the topic "OR GHX"

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Aldubyan, Mohammad Hasan. "Thermo-Economic Study of Hybrid Photovoltaic-Thermal (PVT) Solar Collectors Combined with Borehole Thermal Energy Storage Systems." University of Dayton / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1493243575479443.

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Lubbers, Ellen MR. "Investigation of adiponectin and its receptors in mouse-models of altered growth hormone action: Attempts to understand the link between adipose tissue and longevity." Ohio University Honors Tutorial College / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1340185494.

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Junnila, Riia Karoliina. "In vitro characterization of human growth hormone mutants." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16311.

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Wachstumshormon (GH) besteht aus 191 Aminosäuren, hat eine Molekülmasse von 22kD und ist essentiell für postnatales Wachstum. Es wird aus der Adenohypophyse freigesetzt. GH bindet an einen GH-Rezeptor (GHR) und aktiviert somit über intrazelluläre Signalvorgänge Zielgene, insbesondere das, welches für die Kodierung von insulin-like growth factor (IGF-1) zuständig ist. IGF-1 vermittelt den Großteil aller GH-Signale. Zusammen mit den bereits bekannten GH Mutanten R77C und D112G ist in dieser Studie der neue GH Mutant d188-190 charakterisiert worden. Alle drei Mutanten wurden in heterozygoter Form in kleinwüchsigen Patienten identifiziert. Diesen Patientendaten zu Folge schien es möglich, dass d188-190 eine GH-antagonistische Wirkung besitzt. Zusätzlich wurde die extrem konservierte C-terminale Disulfidbrücke des GH im Mutanten d188-190 unterbrochen vorgefunden. Die Auswirkung der Unterbrechung wurde durch Substitution einer oder beider involvierter Cysteine durch Alanine untersucht. Alle Mutanten und Wildtypen des GH wurden in menschlichen embryonalen Nierenzellen (HEK-293) angezüchtet und eine Reihe von in vitro Experimenten sind für deren Charakterisierung etabliert worden. Es zeigte sich, dass d188-190 keine GH-antagonistische Wirkung besitzt. Im Vergleich zum Wildtyp weist der Mutant eine verminderte Bindungsaffinität zu GH, schwächere biologische Aktivität und höhere Stabilität auf. R77C und D112G sind dem Wildtyp GH sehr ähnlich. Die Disulfidbrücke ist wichtig für die Rezeptorbindung und für die biologische Aktivität von GH. Wenn ein Cystein entfernt wird vermindert sich die Stabilität des Moleküls. Dieser Effekt kann durch Entfernen des zweiten Cysteins wieder rückgängig gemacht werden. Die in dieser Studie etablierten Experimente können Verwendung finden in der Charakterisierung bislang nicht bekannter GH Mutanten und können darüber hinaus zur Behandlung von Patienten eingesetzt werden.
Growth hormone (GH) is a 22 kD, 191-aa, pituitary-derived peptide hormone that is essential for postnatal growth. GH signals via binding to GH receptor (GHR), which initiates intracellular signal transduction pathways. This leads to activation of target genes, most importantly the one encoding insulin-like growth factor (IGF)-1, which mediates most GH action. In this study a novel GH mutant, d188-190, was characterized along with previously reported GH mutants R77C and D112G. All of these mutants had been identified in heterozygous form in patients with retarded growth. Based on patient data, d188-190 was thought to be a GHR antagonist. Moreover, the extremely conserved C-terminal disulfide bridge of GH was disrupted in mutant d188-190 and its role was studied by substituting one or both of the involved cysteines with alanines. All mutants and wild type (wt) GH were produced in human embryonic kidney (HEK)-293 cells and an array of in vitro experiments was established for their characterization. It turned out that the novel d188-190 mutant is not a GHR antagonist after all. It has a diminished binding affinity to GHR, low biological activity and high stability compared to wt GH. R77C and D112G are rather similar to wt GH. The disulfide bridge is important for receptor binding and biological activity of GH. If one of the cysteines is removed the stability of the molecule drops but this can be reversed by removing both cysteines. If further GH mutants are to be identified, the established array of experiments will be useful for their fast characterization and could even contribute to correct treatment of patients.
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Tolle, Virginie. "La ghreline, une nouvelle hormone gastrointestinale se liant au récepteur des GH sécrétagogues : du contrôle de la sécrétion de l'hormone de croissance (GH) à la régulation de la prise alimentaire et des rythmes veille/sommeil." Paris 6, 2002. http://www.theses.fr/2002PA066353.

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Liberato, Marcelo Vizoná. "Caracterização estrutural de endoglucanases da família GH5 e beta-glicosidases da família GH1: interação enzima-substrato." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-28012014-142924/.

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A celulose é o biopolímero de maior abundância no mundo e tem potencial para se tornar fonte de energia renovável através de sua transformação em açúcares fermentáveis, que por sua vez serão transformados em etanol. A recalcitrância da celulose, principal dificuldade encontrada no processo, pode ser superada com o auxílio de enzimas (celulases). Ao menos três enzimas celulolíticas são necessárias para a degradação total da celulose, incluindo as celobioidrolases, que hidrolisam as ligações glicosídicas das extremidades redutoras e não redutoras da cadeia, as endoglucanases, que clivam a cadeia de celulose amorfa randomicamente, e as beta-glicosidases, que produzem glicose através dos celo-oligômeros. Mas para que esse processo se torne financeiramente viável é necessário conhecer o funcionamento, otimizar a atividade e aumentar a produção dessas celulases. Com o intuito de avançar na compreensão da função e estrutura dessas enzimas, o presente trabalho teve como objetivo o estudo estrutural de beta-glicosidases da família GH1 e endoglucanases da família GH5. Na primeira parte do trabalho, a expressão da endoglucanase II de Trichoderma reesei não foi alcançada, mesmo utilizando diferentes organismos e condições de expressão. Porém, na segunda etapa, foi obtida a expressão, purificação e os primeiros ensaios de cristalização de 11 beta-glicosidases bacterianas da família GH1 e 8 endoglucanases bacterianas da família GH5. Dentre elas, três beta-glicosidases e uma endoglucanase de Bacillus licheniformis foram cristalizadas e tiveram sua estrutura resolvida. As beta-glicosidases, apesar de possuírem o enovelamente similar, apresentaram variações no tamanho e posição das alças formadoras da fenda catalítica e divergem em relação a um dos aminoácidos importantes para a estabilização do substrato. Essas diferenças podem ajudar a explicar o mecanismo dessas enzimas para reconhecer substratos distintos. A endoglucanase da família GH5, possuindo dois módulos acessórios, foi cristalizada tanto na forma apo quanto complexada ao substrato celotetraose. O segundo módulo acessório possivelmente é um domínio de ligação à celulose (CBM) e seus resíduos aromáticos, que são responsáveis pela interação com o substrato, parecem complementar o sítio catalítico, sendo assim um novo mecanismo de auxílio enzimático de um CBM. O primeiro módulo acessório não possui um aparente sítio de interação com carboidratos e provavelmente funciona como um conector entre domínio catalítico e o CBM. O posicionamento do substrato no sítio de ligação é parecido com outras estruturas já determinadas, porém, suscita algumas dúvidas sobre a função dos resíduos catalíticos que é conservada na família. O carbono anomérico do substrato possui uma densidade eletrônica contínua com o glutamato da fita β4 (que deveria ser o ácido/base) e está mais próximo dele que do glutamato da fita β7 (que deveria ser o nucleófilo).
Cellulose is the most abundant biopolymer in the world and can become a renewable energy source through its transformation in fermentable sugars, which will be converted in bioethanol. The cellulose recalcitrance, main difficulty in the process, can be overcome with the aid of enzymes (cellulases). At least three cellulolytic enzymes are required for complete hydrolysis of cellulose, including cellobiohydrolases for hydrolyzing the glycosidic linkages from the reducing and non-reducing chain ends, endoglucanases for randomly cleaving cellulose chains in the amorphous regions, and beta-glucosidases for producing glucose from the solubilized cello-oligomers. But, to become a financially viable process it is necessary to know the mechanism, optimize the activity and improve the production of these cellulases. In order to advance the understanding of the structure and function of these enzymes, the present work intended to study the structure of beta-glucosidases from family GH1 and endoglucanases from family GH5. In the first part of the work, the expression of endoglucanase II from Trichoderma reesei was not achieved, even using different organisms and expression conditions. However, in the second part, the expression, purification and the crystallization first trials of eleven bacterial beta-glucosidases and eight bacterial endoglucanases were achieved. Among them, three beta-glucosidases and one endoglucanase from Bacillus licheniformis were crystallized and had their structures solved. Beta-glucosidases, although having a similar folding, showed variations in the length and position of the loops that form the catalytic cleft and diverge in relation to one of the amino acids that are important in substrate stabilization. These differences may help explain the mechanism of these enzymes to recognize distinct substrates. The endoglucanase, which has two accessory modules, was crystallized in the apo form and complexed with the substrate celotetraose. The second accessory module probably is a cellulose binding domain (CBM) and its aromatic residues, which are responsible for the substrate interaction, seem to complement the catalytic site. Therefore it can be a new mechanism of CBM assistance in the enzymatic activity. The first accessory module has no apparent interaction site with carbohydrates and probably works as a connector between the catalytic domain and CBM. The positioning of the substrate in the binding site is similar to other structures already solved but raises some questions about the role of the catalytic residues, that are conserved in the family. The anomeric carbon of the substrate has a continuous electron density with glutamate from sheet-β4 (which should be the acid/base) and is closer to it than to glutamate from sheet-β7 (which should be the nucleophile).
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Mear, Yves. "Implication de l'activité constitutive du récepteur de la ghréline dans la tumorigenèse des adénomes somatotropes." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5102.

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Les adénomes hypophysaires sont les tumeurs intracérébrales les plus fréquentes. Les adénomes somatotropes hypersécrètent l’hormone de croissance (GH) et sont traités classiquement par des analogues somatostatinergiques. Une petite moitié des patients acromégales est néanmoins résistante à ces traitements. L’on sait depuis, quelques années, que le récepteur de la ghréline possède une forte activité constitutive et joue un rôle majeur dans la sécrétion de GH. Cette activité constitutive est-elle impliquée dans la tumorigenèse des adénomes somatotropes ? Nos travaux ont montré un niveau de transcrits, codant pour le GHS-R, particulièrement élevé dans ces tumeurs, et l’immunocytochimie révèle un marquage punctiforme localisé à la membrane plasmique. La MSP (agoniste inverse du GHS-R) induit une diminution dose-dépendante de la sécrétion de GH des cultures primaires d’adénomes somatotropes. Cette efficacité de la MSP sur la sécrétion de l’hormone de croissance est particulièrement remarquable sur les patients résistants aux agonistes somatostatinergiques chez qui elle démontre une efficacité relative accrue. Des clones, surexprimant le GHS-R humain (lignées MYST-R), ont été générés à partir de lignées somato-lactotropes tumorales de rat (GH4C1). Sur ces cellules, le ligand endogène du GHS-R induit une augmentation d’IP3 intracellulaire. De façon originale, la MSP induit une diminution du niveau d’IP3 intracellulaire. L’inhibition de l’activité constitutive du GHS-R par un agoniste inverse, tel que la MSP, pourrait permettre de réprimer l’hypersécrétion de GH, faisant de cette molécule une alternative pharmacologique aux traitements actuels des adénomes somatotropes
Pituitary tumors are most usual intracranial tumors. The somatotroph adenomas are characterised by a GH hypersecretion. The current treatments are based on somatostatinergic agonists. Unfortunately, there is steel 50% of patients, which remain insensitive to these treatments. The aim of our work was to find a pharmacological alternative to treat the patients resistant to the current therapies. Ghrelin stimulate pituitary GH release in vivo through GHS-R1a activation. Interestingly, this receptor transduces signal through an unusual high constitutive activity. Noteworthy, human somatotroph adenomas expressed a high level of GHS-R1a at both mRNA and protein level. We actually assess the implication of this constitutive activity in the tumorigenesis of the somatotroph adenomas. Firstly we demonstrated GHS-R1a functionality through its capacity to fixe endogenous ligand. Then we showed that treatment of human somatotroph adenomas primary cultures, with the GHS-R1a inverse agonist (MSP: Modified Substance P), induced a dose dependent decrease of GH secretion. To foremost investigate the transduction mechanisms underlying these results, we developed, from GH4C1 (rat somato-lactotroph tumoral cell line), stable monoclonal cell lines overexpressing human GHS-R1a (named MYST-Rg). Interestingly MYST-Rg cells exhibit relatively high basal activation of the IP3 pathway. GHS-R1a endogenous ligand (ghrelin) strengthens basal IP3 pathway activation of MYST-Rg cells. Noteworthy, the basal IP3 pathway activation can be lessened by MSP treatment. Thus, MSP could be a useful alternative to the current therapies of somatotroph adenomas
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Araújo, Juscemácia Nascimento. "Sintese e caracterizacao de nanoparticulas de prata assistidas por B-glicosidases (GH1 e GH3) de Thermotoga petrophila." reponame:Repositório Institucional da UFABC, 2017.

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Orientador: Prof. Dr. Wanius José Garcia da Silva
Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biotecnociência, 2017.
A hidrolise enzimatica da celulose e realizada pela acao sinergica de pelo menos tres tipos de celulases distintas: endoglucanases, exoglucanases e B.glicosidases. As endoglucanases e celobiohidrolases sao frequentemente inibidas pelo aumento da concentracao de celobiose (dimero de glicose) no meio reacional. As ¿À-glicosidases sao enzimas que clivam celobiose em monomeros de glicose. Portanto, as B-glicosidases sao essenciais ao processo de hidrolise da celulose por impedirem o acumulo de celobiose e, assim, evitar a diminuicao da taxa de hidrolise. Processos de pre-tratamento da biomassa lignocelulosica sao empregados, antes da reacao de hidrolise enzimatica da celulose, a fim de retirar a fracao de lignina e aumentar a taxa de conversao da celulose em glicose. Porem, estes processos de pre-tratamento da biomassa lignocelulosica nao sao 100% eficientes na remocao da lignina. Estudos previos mostraram que a adicao de lignina a celulose pura pode causar a reducao da liberacao de acucar em valores superiores a 60%. Assim, neste estudo, nos caracterizamos a adsorcao nao produtiva da enzima ¿À-glicosidase da familia GH1 da bacteria Thermotoga petrophila (TpBGL1) em ligninas extraidas de diferentes biomassas (cana-de-acucar e eucalipto). Em pH 7 e 6, nossos resultados indicaram que a repulsao eletrostatica enfraquece a adsorcao nao produtiva de TpBGL1 em ligninas. Contudo, em pH 4 a atracao eletrostatica fortalece a adsorcao nao produtiva. Alem disso, o aumento da temperatura de 25 oC para 70 oC nao resultou em um aumento significativo da adsorcao de TpBGL1 em ligninas, provavelmente porque nao ocorre um aumento significativo de regioes hidrofobicas na estrutura da enzima expostas ao solvente. Todas as informacoes obtidas neste estudo poderao ser uteis para aplicacoes biotecnologicas no campo de conversao de polissacarideos estruturais em bioenergia.
The B-glucosidases are a group of important enzymes employed in a large number of industrial applications. In this study, we reported for the first time the photobiosynthesis of stable and functional silver nanoparticles (AgNPs) using two hyperthermostable bacterial â-glucosidases with industrial potential. The syntheses were simple and rapid processes carried out by mixing â-glucosidases and silver solution under irradiation with light (450-600 nm), therefore, compatible with the green chemistry methodology. The synthesized AgNPs were characterized using a series of physical techniques. Absorption spectroscopy showed a strong absorption band at 460 nm due to surface plasmon resonance of the AgNPs. X-ray diffraction analysis showed that the AgNPs were purely crystalline in nature. Electron microscopy showed AgNPs of variable diameter ranging from 20 to 100 nm. In addition, electron microscopy, zeta potential and Fourier transform infrared spectroscopy results confirmed the presence of â-glucosidases coating and stabilizing the AgNPs. The results also showed that the enzymatic activities were maintained in the â-glucosidases assisted AgNPs. The data described in this study should provide a useful basis for future studies of â-glucosidases assisted AgNPs, including biotechnological applications.
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Kearney, Tara Maria. "The effect of growth hormone replacement (GHR) apolipoprotein B100 (apoB) kinetics in growth hormone deficient (GHD) hypopituitary subjects." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272425.

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Gollapudi, Anantha Srinivasa Babu. "Molecular variants of bovine GH and GHR and their association with milk production traits in Canadian Holstein bulls." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32996.

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In dairy cattle, treatment with exogenous growth hormone (GH) affects growth and function of mammary gland. The actions of GH are mediated via interaction with GH receptors (GHR). The first step in signal transduction is homodimerization of two GHR molecules by GH. This step is critical since mutation in either GH or GHR can block dimerization and thus target cell activation. However, association between milk related traits and combination of GH and GHR variations are not known. Accordingly, DNA genotypes in the GH and GHR genes were investigated for association with milk, fat and protein lactation yields in Holsteins. The marker data were obtained on 873 progeny tested bulls by using PCR-RFLP and PCR-SSCP analysis. There were five markers in GH and three in GHR. Estimated breeding values (EBVs) were obtained from Canadian Dairy Network for milk, fat, and protein lactation yields for the 873 genotyped bulls.
There was significant difference among GH6.1 alleles (C-to-G transversion at position 2141) for the milk yield (P < 0.05) and protein yield (p < 0.05). There were significant differences in GHR AluI (A-to-T transversion at -1182) for milk (p < 0.05) and fat (p < 0.05), and GHR StuI (C-to-T transversion at -232) for fat (p < 0.0001) and protein (p < 0.05). Allele frequencies for GH6.1 (C), GHR AluI (A) and GHR StuI (C) alleles in bulls genotyped were 0.95, 0.63 and 0.95, respectively. Bulls with GH6.1 (C/G) genotype had higher milk EBV (p < 0.05) compared to C/C bulls. Bulls with GHR AluI (A/A) genotype had higher milk EBV (p < 0.01) and fat EBVs (p < 0.05). Bulls with StuI (C/C) genotype had higher fat EBV (p < 0.0001) and protein EBV (p < 0.05) compared to StuI (C/T). This study indicates that the combination of GH and GHR markers could serve as a tool to aid in selection for improving milk, fat, and protein production.
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Jara, Adam. "Growth Hormone (GH) and the Cardiovascular System: Studies in Bovine GH Transgenic and Inducible, Cardiac-Specific GH Receptor Gene Disrupted Mice." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1395792687.

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Books on the topic "OR GHX"

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Sihnā, Prabhāta. Gho' gho' rāṇī. Kaṭaka: Oḍiśā Buk Shṭora, 1994.

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Ght. Edina, Minn: Abdo Pub., 2001.

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Teitelbaum, Michael. GEX. [Mahwah, NJ]: Troll, 1999.

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Pierre, Richard. GHB. [Boisbriand, Québec]: Pratiko, 2007.

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Hò̂, Biẻ̂u Chánh. Mẹ ghẻ con ghẻ: Tiẻ̂u thuyé̂t. [Tiè̂n Giang]: Nhà xuá̂t bản tỏ̂ng hợp Tiè̂n Giang, 1988.

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Coombs, Matthew. Suzuki GSX-R600, GSX-R750 & GSX-R1000: Service and repair manual. Sparkford, Yeovil, Somerset, England: Haynes, 2006.

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Coombs, Matthew. Suzuki GSX-R600, GSX-R750 & GSX-R1000: Service and repair manual. 2nd ed. Sparkford: Haynes, 2010.

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Mather, Phil. Suzuki GSX-R600, GSX-R750, and GSX-R1000: Service & repair manual. Sparkford, Nr Yeovil, Somerset, England: Haynes Pub., 2006.

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Stermilli, Haki. Sikur te isha djale: Roman. Tirane: Shtepia Botuese "Letrat", 2002.

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Hiền, Quý. Muon ghe. Hà Nội: Nhà xuất bản Sân khấu, 2003.

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Book chapters on the topic "OR GHX"

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Manji, Husseini K., Jorge Quiroz, R. Andrew Chambers, Anthony Absalom, David Menon, Patrizia Porcu, A. Leslie Morrow, et al. "GHB." In Encyclopedia of Psychopharmacology, 559. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4275.

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Weik, Martin H. "GHz." In Computer Science and Communications Dictionary, 681. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_7953.

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Nita, Stefania Loredana, and Marius Mihailescu. "GHC." In Haskell Quick Syntax Reference, 13–18. Berkeley, CA: Apress, 2019. http://dx.doi.org/10.1007/978-1-4842-4507-1_3.

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Luther, Rolf. "GHS." In Encyclopedia of Lubricants and Lubrication, 758. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-22647-2_200186.

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Henssler, Jonathan, and Felix Bermpohl. "GHB." In Handbuch Psychoaktive Substanzen, 631–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-642-55125-3_89.

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Henssler, Jonathan, and Felix Bermpohl. "GHB." In Handbuch Psychoaktive Substanzen, 1–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-642-55214-4_89-1.

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Laflamme, R., E. Knill, W. H. Zurek, P. Catasti, and S. V. S. Mariappan. "NMR GHZ." In Quantum Computing and Quantum Communications, 357–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/3-540-49208-9_32.

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Blizzard, R. M. "Growth hormone deficiency (GHD) and GHD-like syndromes." In Advances in Growth Hormone and Growth Factor Research, 285–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-662-11054-6_19.

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Greenberger, Daniel M. "GHZ (Greenberger—Horne—Zeilinger) Theorem and GHZ States." In Compendium of Quantum Physics, 258–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-70626-7_78.

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Albarrán-Zeckler, Rosie G., and Roy G. Smith. "The Ghrelin Receptors (GHS-R1a and GHS-R1b)." In The Ghrelin System, 5–15. Basel: S. KARGER AG, 2013. http://dx.doi.org/10.1159/000346042.

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Conference papers on the topic "OR GHX"

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Gao, Yuefen, Songling Wang, and Guoqiang Zhang. "Analysis of Regional Suitability of the Ground-Coupled Heat Pump Based on the Shallow Ground Thermal Balance." In ASME 2009 3rd International Conference on Energy Sustainability collocated with the Heat Transfer and InterPACK09 Conferences. ASMEDC, 2009. http://dx.doi.org/10.1115/es2009-90018.

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Ground-coupled heat pump systems use the ground as a heat source and sink either with vertical or horizontal ground heat exchangers (GHXs) to supply heating in winter and cooling in summer. The ground heat source and sink has a near constant temperature, which is well suited to ground-coupled heat pumps, giving them consistent performance, regardless of the outdoor temperature. However, when the heat extracted from and rejected to the ground has great imbalance, the ground temperature will deviate from the original temperature with a long term operation. The deviation can reduce GHX performance greatly. As China has vast territory with variety climate, the annual cooling loads and heating loads are different at different places. And the imbalance between the extracted heat and the rejected heat also varies at different places. Therefore, it is necessary to analysis the regional suitability of the ground-coupled heat pump systems. The imbalance between the extracted heat and the rejected heat is analyzed by taking several typical cities in different climates. The new concepts of the Imbalance Ratio and the Extracted Heat to Rejected Heat Ratio are introduced as the weight factors to measure the imbalance in the ground. The values of the Imbalance Ratio and those of the Extracted Heat to the Rejected Heat Ratio are calculated. The optimum range of the Imbalance Ratio is recommended based on the vast investigation of the ground-coupled heat pumps. Some supplemental systems are put forward to supply heat in winter or to reject heat in summer at the places existing serious heat imbalance. The study is very meaningful to the scientific application of the ground-coupled heat pump systems in China.
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Porras, Frank, Angel D. Ramirez, Arnaldo Walter, and Guillermo Soriano. "Life Cycle Assessment of Greenhouse Gas Emissions: Comparison Between a Cooling Tower and a Geothermal Heat Exchanger for Air Conditioning Applications in Ecuador." In ASME 2019 13th International Conference on Energy Sustainability collocated with the ASME 2019 Heat Transfer Summer Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/es2019-3907.

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Abstract Cooling towers are widely used to remove heat in buildings with chilled water air conditioning systems. Moreira et al. [1] performed an experimental comparison between a cooling tower (CT) and a geothermal heat exchanger (GHE) in Guayaquil-Ecuador (hot/humid climate) and the results show an advantage of 39% of GHE systems regarding energy efficiency. This study compares the emissions of greenhouse gases (GHG), considering the results of the research mentioned above and comparing both systems. A life cycle assessment (LCA) approach was used to estimate the GHG emissions, assuming three scenarios for the electricity supply: the electricity generation mix in 2016, the planned electricity generation mix in 2025, and the profile for marginal electricity generation (peak demand). The estimated reduction of GHG emissions due to the use of GHE systems could be up to 50%. GHEs for building air conditioning applications is a technological option with potential to reduce energy consumption and GHG emissions. However, additional work is necessary to evaluate the complete environmental profile and its cost-effectiveness.
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Hasegawa, Keichi, Kazuo Kusaka, Akinaga Kumakawa, Masahiro Sato, Makoto Tadano, and Hideaki Takahashi. "Laser Ignition Characteristics of Gox/GH2 and Gox/GCH4 Propellants." In 39th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2003. http://dx.doi.org/10.2514/6.2003-4906.

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Liu, Xueli, Shun Yao, John Gibson, and Stavros V. Georgakopoulos. "Frequency Reconfigurable QHA Based on Kapton Origami Helical Tube for GPS, Radio and WiMax Applications." In ASME 2017 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/detc2017-68048.

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Origami tubes are deployed to realize a compactable and frequency reconfigurable quadrifilar helical antenna (QHA). The specific origami pattern is parametrically analyzed to help with antenna modelling and simulation at reconfigurable states. Two quadrifilars respectively on helical tube and bellow tube are proposed, and the quadrifilar on helical tube is fabricated with 4-mil Kapton substrate. Measured results show that this Kapton QHA can operate with right-handed circularly polarized (RHCP) radiation patterns at 4 reconfigurable states with: ±1dB RHCP gain bandwidth from 1.05 GHz-1.4 GHz at state 1 with total antenna height H = 203 mm; ±1dB RHCP gain bandwidth from 1.4 GHz-1.73 GHz at state 2 with total antenna height H = 168 mm; ±1dB RHCP gain bandwidth from 2.07 GHz-2.7 GHz at state 3 with total antenna height H = 69 mm; ±1dB RHCP gain bandwidth from 2.7 GHz-2.94 GHz and 3.26 GHz-3.66 GHz at state 4 with total antenna height H = 54 mm. Therefore, this antenna can be reconfigured and applied in space and remote communication applications, such as GPS (1.17 GHz-1.58 GHz), radio (2.305 GHz-2.315 GHz) and WiMax (3.5 GHz).
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Kumari, Tejaswita, Prabir Ghosh, and Atanu Chowdhury. "L-Slots Square Antenna for Octa-band Applications." In International Conference on Women Researchers in Electronics and Computing. AIJR Publisher, 2021. http://dx.doi.org/10.21467/proceedings.114.39.

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The objective of this paper is to design an Octa- Band L-slot Square Patch antenna which will operate in 3.18 GHz, 4.71 GHz, 7.04 GHz, 8.38 GHz, 8.86 GHz, 10.66 GHz, 11.76 GHz, 14.12 GHz frequencies. The same antenna would also work in UWB frequencies. An L-slots Square copper patch with a thickness 0.035mm is placed on FR4 epoxy substrate having dielectric constant 4.4 with a height of 1.6 mm with single port. This has been designed using HFSS commercial software simulator so that Return Loss, VSWR, Radiation pattern and Surface current distribution can be measured.
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T. Antonio, Carl Abelardo. "Policy Critique: The Philippine’s Magna Carta of Public Health Workers." In 2nd Annual Global Healthcare Conference (GHC 2013). Global Science and Technology Forum Pte Ltd, 2013. http://dx.doi.org/10.5176/2251-3833_ghc13.08.

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Buultjens, Melissa, Priscilla Robinson, Gregory Murphy, and Jeannette Milgrom. "The Outcomes of an Exploration of Maternity Models of Care and Allied Health Service Delivery in the Public Sector across Victoria, Australia." In 2nd Annual Global Healthcare Conference (GHC 2013). Global Science and Technology Forum Pte Ltd, 2013. http://dx.doi.org/10.5176/2251-3833_ghc13.13.

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Ngum Chi, Mimmie, and Pranee Liamputtong. "Sensitive research and vulnerable participants: Accessing and conducting research with African Australian teenage mothers in greater Melbourne, Australia." In 2nd Annual Global Healthcare Conference (GHC 2013). Global Science and Technology Forum Pte Ltd, 2013. http://dx.doi.org/10.5176/2251-3833_ghc13.15.

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Lukas, Daniel. "Health and Knowledge: Patient Autonomy and Specific Medical Education." In 2nd Annual Global Healthcare Conference (GHC 2013). Global Science and Technology Forum Pte Ltd, 2013. http://dx.doi.org/10.5176/2251-3833_ghc13.20.

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Oanh, Tran Thi Mai, Khuong Anh Tuan, Hoang Thu Thuy, Hoang Thi Phuong, Nguyen Thi Thang, Nguyen Minh Hieu, Nguyen Thi Thuy, et al. "ATTRACTION TO AND RETENTION OF HEALTH WORKFORCE IN DISAVANTAGED AREAS IN VIETNAM – A CASE STUDY OF POLICY IMPLEMENTATION." In 2nd Annual Global Healthcare Conference (GHC 2013). Global Science and Technology Forum Pte Ltd, 2013. http://dx.doi.org/10.5176/2251-3833_ghc13.22.

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Reports on the topic "OR GHX"

1

Bergeron, G., M. Czarnaski, and M. Rhinewine. Scaling of an 85 GHz Gyrotron to Operate at 94 GHz. Fort Belvoir, VA: Defense Technical Information Center, September 1989. http://dx.doi.org/10.21236/ada212756.

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Skone, Timothy J. Indirect Land Use GHG. Office of Scientific and Technical Information (OSTI), December 2012. http://dx.doi.org/10.2172/1509279.

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Barnum, Thomas J. A 94 GHz Transmissometer. Fort Belvoir, VA: Defense Technical Information Center, May 1990. http://dx.doi.org/10.21236/ada223309.

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Kreischer, Kenneth, Jack Tucek, Mark Basten, and David Gallagher. Integrated 220 GHz Source Development. Fort Belvoir, VA: Defense Technical Information Center, May 2014. http://dx.doi.org/10.21236/ada610341.

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Skone, Timothy J. Direct Land Use GHG, Reversion. Office of Scientific and Technical Information (OSTI), August 2013. http://dx.doi.org/10.2172/1509272.

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Crane, Robert K. 5/15 GHZ Scattering Study. Fort Belvoir, VA: Defense Technical Information Center, May 1991. http://dx.doi.org/10.21236/ada236350.

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Hejdenberg, Jennie. Improving GHB withdrawal with baclofen. National Institute for Health Research, July 2021. http://dx.doi.org/10.3310/nihropenres.1115156.1.

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Hirshfield, Jay L. SEVENTH HARMONIC 20 GHz CO-GENERATOR. Office of Scientific and Technical Information (OSTI), April 2014. http://dx.doi.org/10.2172/1127219.

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Temkin, Richard J., and Michael A. Shapiro. 17 GHz High Gradient Accelerator Research. Office of Scientific and Technical Information (OSTI), July 2013. http://dx.doi.org/10.2172/1087178.

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Fliflet, A. W., R. P. Fischer, D. Lewis, Rayne III, Bender R. J., and B. D. Microwave Sintering Studies at 2.45 GHz. Fort Belvoir, VA: Defense Technical Information Center, July 1997. http://dx.doi.org/10.21236/ada328545.

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