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Relevant bibliographies by topics / Oral delivery systems

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Academic literature on the topic 'Oral delivery systems'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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Journal articles on the topic "Oral delivery systems"

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Zaman, Muhammad, Junaid Qureshi, Hira Ejaz, Rai Muhammad Sarfraz, Hafeez Ullah Khan, Fazal Rehman Sajid, and Muhammad Shafiq ur Rehman. "Oral controlled release drug delivery system and Characterization of oral tablets; A review." Pakistan Journal of Pharmaceutical Research 2, no. 1 (January 27, 2016): 67. http://dx.doi.org/10.22200/pjpr.2016167-76.

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Oral route of drug administration is considered as the safest and easiest route of drug administration. Control release drug delivery system is the emerging trend in the pharmaceuticals and the oral route is most suitable for such kind of drug delivery system. Oral route is more convenient for It all age group including both pediatric and geriatrics. There are various systems which are adopted to deliver drug in a controlled manner to different target sites through oral route. It includes diffusion controlled drug delivery systems; dissolution controlled drug delivery systems, osmotically controlled drug delivery systems, ion-exchange controlled drug delivery systems, hydrodynamically balanced systems, multi-Particulate drug delivery systems and microencapsulated drug delivery system. The systems are formulated using different natural, semi-synthetic and synthetic polymers. The purpose of the review is to provide information about the orally controlled drug delivery system, polymers which are used to formulate these systems and characterizations of one of the most convenient dosage form which is the tablets.

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Ranade, Vasant V. "Drug Delivery Systems 5A. Oral Drug Delivery." Journal of Clinical Pharmacology 31, no. 1 (January 1991): 2–16. http://dx.doi.org/10.1002/j.1552-4604.1991.tb01881.x.

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Ranade, Vasant V. "Drug Delivery Systems 5B. Oral Drug Delivery." Journal of Clinical Pharmacology 31, no. 2 (February 1991): 98–115. http://dx.doi.org/10.1002/j.1552-4604.1991.tb03693.x.

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Maroni, Alessandra, Lucia Zema, Matteo Cerea, and Maria Edvige Sangalli. "Oral pulsatile drug delivery systems." Expert Opinion on Drug Delivery 2, no. 5 (September 2005): 855–71. http://dx.doi.org/10.1517/17425247.2.5.855.

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Bruschi, Marcos Luciano, and Osvaldo de Freitas. "Oral Bioadhesive Drug Delivery Systems." Drug Development and Industrial Pharmacy 31, no. 3 (March 1, 2005): 293–310. http://dx.doi.org/10.1081/ddc-200052073.

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Bruschi, Marcos Luciano, and Osvaldo de Freitas. "Oral Bioadhesive Drug Delivery Systems." Drug Development and Industrial Pharmacy 31, no. 3 (January 2005): 293–310. http://dx.doi.org/10.1081/ddc-52073.

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Kumar, P. S., P. Clark, M. C. Brinkman, and D. Saxena. "Novel Nicotine Delivery Systems." Advances in Dental Research 30, no. 1 (September 20, 2019): 11–15. http://dx.doi.org/10.1177/0022034519872475.

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Electronic nicotine delivery systems (ENDS) are devices that contain a power source, a heating element, and a tank or cartridge containing an “e-liquid,” which is a mixture of nicotine and flavoring in a glycerol–propylene glycol vehicle. Their increasing popularity among adolescents might be attributed to aggressive marketing in physical venues, social media outlets, as well as irreversible changes caused by nicotine in the developing brains of youth and young adults, predisposing them to addictive behaviors. Adolescent ENDS users were 4 times more likely to initiate cigarette smoking, and the odds of quitting smoking were lower and, in many instances, delayed for those using ENDS. ENDS also renormalize cigarette-like behaviors, such as inhaling/exhaling smoke. The oral cavity is the initial point of contact of ENDS and the first affected system in humans. Oral health depends on an intricate balance in the interactions between oral bacteria and the human immune system, and dysbiosis of oral microbial communities underlies the etiology of periodontitis, caries, and oral cancer. Emerging evidence from subjects with periodontitis as well as periodontally healthy subjects demonstrates that e-cigarette use is associated with a compositional and functional shift in the oral microbiome, with an increase in opportunistic pathogens and virulence traits.

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Wong, Tin Wui. "Design of oral insulin delivery systems." Journal of Drug Targeting 18, no. 2 (October 5, 2009): 79–92. http://dx.doi.org/10.3109/10611860903302815.

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O'driscoll, Caitriona. "Micellar systems for oral drug delivery." Journal of Pharmacy and Pharmacology 50, S9 (September 1998): 13. http://dx.doi.org/10.1111/j.2042-7158.1998.tb02213.x.

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Bernkop-Schnürch, Andreas. "Mucoadhesive systems in oral drug delivery." Drug Discovery Today: Technologies 2, no. 1 (March 2005): 83–87. http://dx.doi.org/10.1016/j.ddtec.2005.05.001.

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Dissertations / Theses on the topic "Oral delivery systems"

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Wilding, Ian Robert. "Some studies of oral sustained release of pellet systems." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319343.

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Mahbubani, Krishnaa Trishna Ashok. "Vehicles for the oral delivery of live bacteria." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608290.

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Aldosari, Basmah Nasser Abdullah. "Development and evaluation of self-nanoemulsifying drug delivery systems for oral delivery of indomethacin." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10044225/.

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In this study, indomethacin-loaded self-nanoemulsifying drug delivery systems (SNEDDS) were developed in liquid, solid and carrier-mediated formulations in order to improve the solubility of this model poorly water soluble drug. Liquid SNEDDS based on CapryolTM 90 (oil phase), Cremophor® RH 40 (surfactant) and Transcutol® HP (co-surfactant) were thermodynamically stable and produced clear nanoemulsions upon dilution. Optimized liquid formulations were transformed into solid SNEDDS by adsorption onto the inert carriers Syloid® XDP 3150, Neusilin® US2 and Florite® PS-200. Ratios of adsorbent: liquid SNEDDS of 1:1.5 and 1:2 resulted in solid SNEDDS formulations that exhibited fair to passable powder flow properties. Carrier-based solid SNEDDS formulations were developed using the solid self-emulsifying carriers Gelucire® 44/14 and Gelucire® 48/16 and prepared by hot melt extrusion. The absorbent-based solid SNEDDS maintained the self-nanoemulsification properties of the original liquid SNEDDS formulations, with solid state analysis suggesting that the drug had remained in a dissolved state within these formulations. Similarly, physical characterization of the carrier-based solid SNEDDS formulations indicated that the drug was molecularly dispersed within the system and that the self-nanoemulsifying properties of the carrier were unchanged. The only exception was those formulations prepared at the highest drug: carrier ratio (3: 10). For both absorbent-based and carrier-based solid SNEDDS, the in vitro dissolution efficiency was significantly higher than that obtained for the pure drug. However, incorporation of adsorbents into Gelucire®-based solid SNEDDS formulations resulted in reduced dissolution of the drug. Gelucire®48/16-based solid SNEDDS prepared at 50oC were more physically stable to storage at 30oC/75% RH for 6 months than formulations processed at 40oC, suggesting that complete melting of the carrier during manufacture is essential for production of physically stable formulations. Overall, a range of liquid, solid and carrier-based SNEDDS formulations were successfully developed and offer useful alternatives to improving the solubility of poorly water-soluble drugs.

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Low, Bee Koen. "Investigation of hydrophilic materials in time-delayed oral delivery systems." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288718.

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Al, Sukhun Rajaa Abed El-Kader. "Lipid drug delivery systems and their fate after oral administration." Thesis, University of Bath, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665369.

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A novel class of lipid formulation was investigated comprising GRAS (generally regarded as safe) materials. The formulations were all ‘surfactant-free’ (S-F) formulations, and also referred to as ‘Type IV’ lipid formulations. These formulations were isotropic, transparent, thermodynamically stable at room temperature and typically composed of > 50 % of mixed mono-, di- and triglycerides, > 30 % medium chain fatty acids oil and < 20 % hydrophilic co-solvent. At equilibrium, S-F formulations enhanced the solvent capacity of corticosteroids (log P > 3) and hydroxy benzoate derivatives over type II SEDDS and type III SEDDS, but generally were not superior solvents to mixtures of mono-, di- and triglycerides (Imwitor 988® and or Capmul MCM®) alone, for lipophilic steroids (log P < 3). In general, type III SEDDS which were composed of high hydrophilic content (hydrophilic surfactant, HLB > 1 2 , and hydrophilic co-solvent), were also better solvents for most steroidal compounds and hydroxy benzoate derivatives than type II SEDDS and type I SEDDS formulations. Surfactant with HLB > 12 inhibited lipolysis of MCT and mixed glycerides when the concentration of surfactant exceeded 40 % w/w. Hydrophobic surfactants (HLB < 10) did not inhibit lipolysis. Thus, the digestibility of dispersions formed by selfemulsifying systems would be dependent on the surfactants used and the quantity of TG available for lipolysis. Co-solvents did not appear to influence lipolysis, once the formulations had dispersed. Phase separation of lipid formulations following their dispersion in simulated intestinal fluid was studied. The lipid formulation behaviour was dependent on monoglyceride content. When sufficient monoglyceride (> 60 %w/v) was present demulsification and phase separation was noticed and was found to be dependent on the presence of phospholipid. This resulted in sedimentation of the phase rich V monoglyceride and water. The presence of triglyceride stabilised the formation of mixed micelles, which remained in a finely dispersed state. This unexpected phase separation is likely to have a considerable effect on the fate of drug dissolved in SEDDS formulations. The high concentrations of monoglyceride may be disadvantageous and could possibly result in precipitation of drug.

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Mota, Joana [Verfasser]. "Matrix- and reservoir-type oral multiparticulate drug delivery systems / Joana Mota." Berlin : Freie Universität Berlin, 2010. http://d-nb.info/1024784770/34.

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Samaligy, Samar el [Verfasser]. "Floating Systems for Oral Controlled Release Drug Delivery / Samar El Samaligy." Berlin : Freie Universität Berlin, 2010. http://d-nb.info/1024784614/34.

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Arca, Hale Cigdem. "Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/82920.

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Amorphous solid dispersion (ASD) is a popular method to increase drug solubility and consequently poor drug bioavailability. Cellulose ω-carboxyesters were designed and synthesized specifically for ASD preparations in Edgar lab that can meet the ASD expectations such as high Tg, recrystallization prevention and pH-triggered release due to the free -COOH groups. Rifampicin (Rif), Ritonavir (Rit), Efavirenz (Efa), Etravirine (Etra) and Quercetin (Que) cellulose ester ASDs were investigated in order to increase drug solubility, prevent release at low pH and controlled release of the drug at small intestine pH that can improve drug bioavailability, decrease needed drug content and medication price to make it affordable in third world countries, and extent pill efficiency period to improve patient quality of life and adherence to the treatment schedule. The studies were compared with cellulose based commercial polymers to prove the impact of the investigation and potential for the application. Furthermore, the in vitro results obtained were further supported by in vivo studies to prove the significant increase in bioavailability and show the extended release. The need of new cellulose derivatives for ASD applications extended the research area, the design and synthesis of a new class of polymers, alkyl cellulose ω-carboxyesters for ASD formulations investigated and the efficiency of the polymers were summarized to show that they have the anticipated properties. The polymers were synthesized by the reaction of commercial cellulose alkyl ethers with benzyl ester protected, monofunctional hydrocarbon chain acid chlorides, followed by removal of protecting group using palladium hydroxide catalyzed hydrogenolysis to form the alkyl cellulose wcarboxyalkanoate. Having been tested for ASD preparation, it was proven that the polymers were efficient in maintaining the drug in amorphous solid state, release the drug at neutral pH and prevent the recrystallization for hours, as predicted.
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Sankaranarayanan, Thampi Sajeesh. "Development of advanced drug delivery systems based on polymethacrylic acid nano/microparticles for oral insulin delivery." Paris 11, 2010. http://www.theses.fr/2010PA114805.

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L’étude a portée sur le développement de micro- et nanoparticules polymères destinées à l’administration orale d’insuline. Une méthode de polymérisation radicalaire a été optimisée pour formuler des micro et des nanoparticules à base d’un polymère formant des hydrogels, le poly(acide de méthacrylique). Les particules ont ensuite été modifiées par greffage de résidus cystéine pour introduire des fonctions thiol en vue de renforcer les propriétés de bioadhésion et de promoteur d’adsorption des systèmes obtenus. Les particules ont montré des propriétés intéressantes de chargement en insuline et la libération se fait selon un mode de libération pH sensible. En effet, alors que l’insuline est majoritairement retenue dans la forme pharmaceutique à pH acide correspondant à un milieu gastrique, elle est libérée à un pH neutre voire légèrement basique retrouvé au niveau de l’intestin. Les systèmes ont montré une bonne capacité à améliorer le passage de l’épithélium intestinal sur des monocouches de cellules Caco 2 et sur de l’intestin isolé monté en chambres de Ussing. Au final, ces systèmes ont permis d’induire in vivo une réduction de la glycémie chez des animaux diabétiques et après une administration orale. Les essais menés sur des insulines modifiées ont permis d’identifier une stratégie de modification intéressante basée sur l’association de l’hormone à une cyclodextrine. En revanche, nos résultats suggèrent que la PEGylation de l’insuline n’apporte aucun bénéfice
The work carried out in this thesis was aimed to develop polymer micro- and nanoparticles for the oral administration of insulin. A method of radical polymerization was optimized to design micro and nanoparticles with a hydrogel forming polymer, poly(methacrylic acid) (PMAA). The particles were further modified by the grafting of cystein residues in order to introduce thiol functions which are believed to reinforce mucoadhesive and permeation enhancing properties of the formulation. The particles showed interesting loading properties for insulin and the release of the hormone was found to be pH dependent. Although insulin was mainly retained by the hydrogel particle in releasing medium mimicking the gastric environment, the hormone was released in conditions found in the intestine. The formulated systems have shown to improve the absorption of insulin through the intestinal mucosa in in vitro models including Caco 2 cell monolayers and the Ussing chambers. The microparticles selected from the in vitro experiments for in vivo studies have shown a capacity to deliver active insulin through the oral route to diabetic rats producing a reduction of the glycemia. Tests performed with modified insulin have allowed to identify that among the two strategies followed, this consisting on the association of insulin with a cyclodextrin was the most promising while the one based on the formation of an insulin-PEG conjugate did not brought any benefice

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Swai, Hulda Paulo Shaidi. "Water sorption and drug release behaviour of polymeric systems based on heterocyclic/cyclic methacrylates." Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313482.

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Books on the topic "Oral delivery systems"

1

Jithan, Aukunuru. Oral drug delivery technology. Hyderabad [India]: Pharma Book Syndicate, 2007.

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Nayak, Amit Kumar, and Md Saquib Hasnain. Plant Polysaccharides-Based Multiple-Unit Systems for Oral Drug Delivery. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-10-6784-6.

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service), ScienceDirect (Online, ed. Handbook of non-invasive drug delivery systems: Science and technology. Norwich, N.Y: William Andrew, 2009.

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Bernkop-Schnürch, Andreas. Oral delivery of macromolecular drugs: Barriers, strategies, and future trends. Dordrecht: Springer, 2009.

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Oral bioavailability: Basic principles, advanced concepts, and applications. Hoboken, N.J: John Wiley & Sons, 2011.

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Organization, World Health. WHO/APHIS consultation on baits and baiting delivery systems for oral immunization of wildlife againstrabies, Colorado State University, Fort Collins, Colorado, 10-12 July, 1990. Geneva: World Health Organization, 1990.

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Spray vitamin & nutriceutical revolution: The 21st century vitamin & nutrition delivery system : intra oral nutriceutical sprays resource & guide. Las Vegas, Nev: Magic Life Books, 1999.

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T, O'Hagan Derek, ed. Novel delivery systems for oral vaccines. Boca Raton: CRC Press, 1994.

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Oral mucosal drug delivery. New York: M. Dekker, 1996.

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World Health Organization (WHO). Alternative Systems of Oral Care Delivery (Technical Reports). World Health Organization, 1987.

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Book chapters on the topic "Oral delivery systems"

1

Cardinal, John R., and Avinash Nangia. "Gastric Retentive Drug Delivery Systems." In Oral Bioavailability, 329–41. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118067598.ch20.

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Fix, Joseph A., Kazuhiro Sako, and Toyohiro Sawada. "Controlled-Release Oral Delivery Systems." In ACS Symposium Series, 14–24. Washington, DC: American Chemical Society, 2000. http://dx.doi.org/10.1021/bk-2000-0752.ch002.

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Tiwari, Sandip B., and Ali R. Rajabi-Siahboomi. "Extended-Release Oral Drug Delivery Technologies: Monolithic Matrix Systems." In Drug Delivery Systems, 217–43. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-210-6_11.

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Falk, Karl-Erik, and Jan-Erik Löfroth. "Oral Delivery of Peptide Drugs." In Delivery Systems for Peptide Drugs, 153–58. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9960-6_12.

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Penchala, Sravan, Anh-Nhan Pham, Ying Huang, and Jeffrey Wang. "Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems." In Oral Bioavailability, 343–54. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118067598.ch21.

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Ottenbrite, Raphael M., Ruifeng Zhao, and Sam Milstein. "New Oral Drug Delivery System." In Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems, 51–56. Tokyo: Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-65883-2_10.

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Smart, John D., and Gemma Keegan. "Buccal Drug Delivery Systems." In Oral Controlled Release Formulation Design and Drug Delivery, 169–84. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470640487.ch11.

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Gamazo, Carlos, and Juan M. Irache. "Antigen Delivery Systems as Oral Adjuvants." In Molecular Vaccines, 603–22. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-00978-0_12.

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Kitchens, Kelly M., and Hamidreza Ghandehari. "PAMAM Dendrimers as Nanoscale Oral Drug Delivery Systems." In Nanotechnology in Drug Delivery, 423–59. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-77668-2_14.

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Bhatt, Priyanka, Deepa Patel, Ankita Patel, Akanksha Patel, and Aishwarya Nagarsheth. "Oral Controlled Release Systems: Current Strategies and Challenges." In Novel Drug Delivery Technologies, 73–120. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3642-3_4.

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Conference papers on the topic "Oral delivery systems"

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Tao, S., and T. Desai. "Off-wafer fabrication cytoadhesive micropatch systems for targeted oral drug delivery." In 2006 Bio Micro and Nanosystems Conference. IEEE, 2006. http://dx.doi.org/10.1109/bmn.2006.330931.

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Kim, Jinho, and Jim S. Chen. "Effect of Inhaling Patterns on Aerosol Drug Delivery: CFD Simulation." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-66685.

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Inhaled Pharmaceutical Aerosols (IPAs) delivery has great potential in treatment of a variety of respiratory diseases, including asthma, pulmonary diseases, and allergies. Aerosol delivery has many advantages. It delivers medication directly to where it is needed and it is effective in much lower doses than required for oral administration. Currently, there are several types of IPA delivery systems, including pressurized metered dose inhaler (pMDI), the dry powder inhaler (DPI), and the medical nebulizer. IPAs should be delivered deep into the respiratory system where the drug substance can be absorbed into blood through the capillaries via the alveoli. Researchers have proved that most aerosol particles with aerodynamic diameter of about 1–5 μm, if slowly and deeply inhaled, could be deposited in the peripheral regions that are rich in alveoli [1–3]. The purpose of this study is to investigate the effects of various inhaling rates with breath-holding pause on the aerosol deposition (Dp = 0.5–5 μm) in a human upper airway model extending from mouth to 3rd generation of trachea. The oral airway model is three dimensional and non-planar configurations. The dimensions of the model are adapted from a human cast. The air flow is assumed to be unsteady, laminar, and incompressible. The investigation is carried out by Computational Fluid Dynamics (CFD) using the software Fluent 6.2. The user-defined function (UDF) is employed to simulate the cyclic inspiratory flows for different IPA inhalation patterns. When an aerosol particle enters the mouth respiratory tract, its particles experience abrupt changes in direction. The secondary flow changes its direction as the airflow passes curvature. Intensity of the secondary flow is strong after first bend at pharynx and becomes weaker after larynx. In flow separation, a particle can be trapped and follow the eddy and deposit on the surface. Particle deposition fraction generally increases as particle size and inhaling airflow velocity increase.

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Goettsche, T., A. Schumacher, J. Kohnle, S. Messner, and R. Zengerle. "Highly integrated oral drug delivery system with valve based on Electro-Active-Polymer." In 2007 IEEE 20th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2007. http://dx.doi.org/10.1109/memsys.2007.4433071.

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Teo, Ka Yaw, Basma Ibrahim, Seungman Park, Yeo Yoon, and Bumsoo Han. "Enhanced Transmucosal Transport Using Osmolyte-Mediated Fluid-Matrix Interaction." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53102.

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Various drug delivery systems are developed to deliver therapeutic and diagnostic agents to tissues covered with mucus, such as airways, nasal cavity, or oral cavity [1]. However, the mucus, which present for protection of the tissues, significantly hinders the transport of these agents and ultimately mitigates their efficacy [2]. Several studies have been performed to improve the transmucosal transport by studying the transport rates of polymeric nanoparticles with various sizes and surface chemistry [3–5]. However, drug delivery systems with improved transmucosal transport capability are still highly desired.

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Bartos, Csaba, and Piroska Szabó-Révész. "Formulation of a solid oral drug delivery systems containing nanosuspension produced by combined wet milling technique." In I. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2019. http://dx.doi.org/10.14232/syrptbrs.2019.op20.

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Anicescu, Maria-Cristina, Cristina-Elena Dinu-Pirvu, Mihaela Violeta Ghica, Valentina Anuta, Razvan Mihai Prisada, Marina-Theodora Talianu, and Lacramioara Popa. "Preliminary analysis of emulsion-based formulations containing pumpkin seed oil and hemp seed oil for internal use." In The 8th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2020. http://dx.doi.org/10.24264/icams-2020.ii.1.

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With a long tradition in pharmaceutical design, emulsions are functional formulations that can maintain their adaptive power connected with the new formulation requirements. Hence, this study proposed preliminary assays concerning the obtaining of natural emulsions for oral administration, incorporating pumpkin seed oil and hemp seed oil as oil phases, with lecithin as emulsifying agent. Using emulsification method, O/W and W/O emulsions were prepared and characterized from a stability point of view considering organoleptic parameters, conductivity properties followed by an extensive superficial analysis by fitting two different goniometric approaches like contact angle and pendant drop models. The emulsions obtained were stable, homogeneous, their properties being reflected by composition. Conductivity values confirmed the type of emulsions, completing their profile. Superficial analysis revealed that lecithin can sustain a proper stability due to a variation of surface tension values around 25 mN/m. The mean contact angle values ranging between 31.87±0.51° and 44.01±5.48° defined an adequate wettability, being correlated with the internal structure. To conclude, this preliminary study offered important data concerning the stability of some emulsions for oral delivery, accessing natural biocompatible components. On this way, it can be created multifunctional systems with nutritional value, but also special vehicles designed for drug delivery.

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Krasnoshtanova, Alla, and Anastasiya Bezyeva. "DETERMINATION OF THE OPTIMAL CONCENTRATIONS OF PECTIN AND CALCIUM CHLORIDE FOR THE SYNTHESIS OF CHITOSAN-PECTIN MICROPARTICLES." In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b1/v3/09.

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"The oral route of drug inclusion is the most convenient for the patient. In addition to ease of use, this method of drug inclusion has such advantages as non-invasiveness of inclusion, absence of complications during injection; comparative safety for the organism due to the passage of the active substance and auxiliary compounds through the gastrointestinal tract; the possibility of introducing larger doses of the drug at one time. However, despite the obvious advantages, the oral route of inclusion has a number of significant disadvantages that significantly limit its use for a number of drugs. Among them are: relatively slow therapeutic action of the drug with this route of inclusion; the aggressive effect of a number of drugs (for example, antibiotics) on the gastrointestinal tract; low bioavailability of a number of substances (especially high molecular weight hydrophilic compounds), caused by poor permeability of the intestinal epithelium for hydrophilic and large molecules, as well as enzymatic and chemical degradation of the active substance in the gastrointestinal tract. There are various approaches used in the development of oral drug delivery systems. In particular, for the targeted delivery of drugs, it is proposed to use nano- and microcapsules with mucoadhesive properties. Among the polymers used for the synthesis of these microparticles, it is preferable to use pH-dependent, gelable biopolymers that change their structure depending on the acidity of the environment. Microcapsules obtained from compounds with the above properties are capable of protecting the active substance (or from the active substance) in the stomach environment and ensuring its release in the intestine. These properties are possessed by such polysaccharides as alginate, pectin, carrageenan, xylan, etc. The listed biopolymers are non-toxic, biocompatible, and biodegradable, which makes microparticles containing these polysaccharides promising as oral drug delivery systems. To impart mucoadhesive properties to nanoparticles, complexes of the listed polymers with chitosan are used. In this research, pectin, a polysaccharide formed mainly by residues of galacturonic acid, was used as a structural polymer. The concentrations of substances in the initial solutions were selected that were optimal for the synthesis of microcapsules. The main parameters for evaluating the resulting microparticles were the size of the capsules (less than 1 μm for oral inclusion), the zeta-potential, showing the tendency of the microparticles to stick together, and the completeness of the binding of the microparticles to chitosan. It was found that the optimal solutions for the synthesis of microparticles are: 15.7 ml of a solution of pectin 0.093% by weight, 3.3 ml of a solution of chitosan 0.07% by weight and 1.0 ml of a solution of CaCl2 20 mM. The diameter of the microparticles obtained by this method was 700-800 nm, and the value of their zetta-potential, equal to - (34 ± 3) mV, does not cross the particle adhesion threshold. It was also found that the synthesis of microparticles at these concentrations of calcium chloride provides the most complete binding of chitosan to their surface, which increases the mucoadhesive properties of microparticles."

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Sun, Feng, Robert Anderson, and Guillermo Aguilar. "An Experimental Study of In Vitro Transdermal Drug Delivery Assisted by Cryopneumatic Technology." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204240.

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Transdermal drug delivery (TDD) is a promising alternative to conventional drug delivery approaches, such as oral or injectable routes. In comparison, the primary benefits of TDD include [1]: 1) avoidance of first pass metabolism and other variables associated with the GI tract such as pH changes and gastric emptying time. 2) sustained and controlled delivery over a prolonged period of time. 3) reduction in side effects associated with systemic toxicity. 4) improved patient acceptance and compliance. 5) direct access to targeted or diseased site, e.g. treatment of skin disorders. 6) ease of dose termination in the event of any adverse reactions either systemic or local; 7) convenient and painless administration; 8) ease of use and reduction of overall health care treatment costs; 9) viable alternative in circumstances where oral dosing is not possible (in unconscious or nauseated patients).

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Kaur, Parmandeep, and Diptiman Choudhury. "Abstract 310: Gut microflora mediated novel oral drug delivery system." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-310.

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Giamberini, Marta, Bartosz Tylkowski, Magdalena Olkiewicz, Belén Reig, Karolina Matulewicz, and Łukasz Kaźmierski. "Chitosan/alginate based macrocapsules as an oral delivery system of DCA." In 14th Mediterranean Congress of Chemical Engineering (MeCCE14). Grupo Pacífico, 2020. http://dx.doi.org/10.48158/mecce-14.dg.08.06.

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Reports on the topic "Oral delivery systems"

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Deluca, Patrick P. Development of a Sustained Antiplague, Antimicrobial Delivery System for KSL Localized in the Oral Cavity. Fort Belvoir, VA: Defense Technical Information Center, May 2004. http://dx.doi.org/10.21236/ada428511.

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