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Journal articles on the topic 'Oral erythroplakia'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Reichart, Peter A., and Hans Peter Philipsen. "Oral erythroplakia—a review." Oral Oncology 41, no. 6 (2005): 551–61. http://dx.doi.org/10.1016/j.oraloncology.2004.12.003.

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2

Nomura, Sachie, Takashi Kakizawa, Masayuki Takano, et al. "Three cases of oral erythroplakia." Journal of Japan Society for Oral Tumors 11, no. 1 (1999): 29–34. http://dx.doi.org/10.5843/jsot.11.29.

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3

Holmstrup, P. "Oral erythroplakia-What is it?" Oral Diseases 24, no. 1-2 (2018): 138–43. http://dx.doi.org/10.1111/odi.12709.

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Dr., M. Kaviya, M. Sathish Kumar Dr., Dr.M.Lavanya, M. Keerthana Dr., S. Kanimozhi Dr., and P. Karthika Dr. "Red Lesions of Oral Cavity: A Review." International Journal of Innovative Science and Research Technology 8, no. 3 (2023): 1603–8. https://doi.org/10.5281/zenodo.7793037.

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The most common oral lesions are erythematous. It will be from benign reactive or immunologically-mediated disorders to malignant diseases. Red patches of the oral mucosa constitute an important group of disorders arising from a diverse spectrum of conditions ranging from traumatic lesions, infectious diseases, systemic and local immune-mediated lesions, to potentially malignant disorders or a neoplasm. Oral erythroplakia is considered a rare potential malignant lesion of the oral cavity. Most red oral lesions are associated with inflammation. Some are potentially malignant, especially erythro

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Wang, Ling, Fengna Qi, Lele Hao, and Honglei Sun. "Evaluation of P53 gene expression by immunohistochemistry to diagnosis oral precancerous lesions." Cellular and Molecular Biology 67, no. 3 (2021): 158–62. http://dx.doi.org/10.14715/cmb/2021.67.3.24.

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Oral Precancerous lesions include leukoplakia, erythroplakia, and mucosa palate changes due to reverse smoking. Assessing the prevalence of these lesions in a cross-sectional study can be effective in the timely prevention and treatment of lesions, in any community. Hence, in the present study, evaluation of P53 gene expression was done by immunohistochemistry method to diagnosis oral precancerous lesions. For this purpose, 111 Chinese patients (54 women and 57 men) were selected for examination. The age range of these patients was 22 to 69 years, and their average age was 32.6 years. All pati

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Sharma, Vipra, Sabyasachi Bandyopadhyay, Kapil Sikka, Aanchal Kakkar, Gururao Hariprasad, and Sundararajan Baskar Singh. "Label-Free Proteomics of Oral Mucosa Tissue to Identify Potential Biomarkers That Can Flag Predilection of Precancerous Lesions to Oral Cell Carcinoma: A Preliminary Study." Disease Markers 2023 (February 1, 2023): 1–16. http://dx.doi.org/10.1155/2023/1329061.

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Oral squamous cell carcinomas are mostly preceded by precancerous lesions such as leukoplakia and erythroplakia. Our study is aimed at identifying potential biomarker proteins in precancerous lesions of leukoplakia and erythroplakia that can flag their transformation to oral cancer. Four biological replicate samples from clinical phenotypes of healthy control, leukoplakia, erythroplakia, and oral carcinoma were annotated based on clinical screening and histopathological evaluation of buccal mucosa tissue. Differentially expressed proteins were delineated using a label-free quantitative proteom

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Yang, S. W., Y. S. Lee, L. C. Chang, T. Y. Hsieh, and T. A. Chen. "Outcome of excision of oral erythroplakia." British Journal of Oral and Maxillofacial Surgery 53, no. 2 (2015): 142–47. http://dx.doi.org/10.1016/j.bjoms.2014.10.016.

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8

Maia, Haline Cunha de Medeiros, Najara Alcântara Sampaio Pinto, Joabe dos Santos Pereira, Ana Miryam Costa de Medeiros, Éricka Janine Dantas da Silveira, and Márcia Cristina da Costa Miguel. "Potentially malignant oral lesions: clinicopathological correlations." Einstein (São Paulo) 14, no. 1 (2016): 35–40. http://dx.doi.org/10.1590/s1679-45082016ao3578.

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ABSTRACT Objective To determine the incidence of potentially malignant oral lesions, and evaluate and correlate their clinical and pathological aspects. Methods The sample consisted of cases clinically diagnosed as oral leukoplakia, oral erythroplakia, erythroleukoplakia, actinic cheilitis, and oral lichen planus treated at a diagnostic center, between May 2012 and July 2013. Statistical tests were conducted adopting a significance level of 5% (p≤0.05). Results Out of 340 patients, 106 (31.2%) had potentially malignant oral lesions; and 61 of these (17.9%) were submitted to biopsy. Actinic che

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9

Das, Rupsa, Satya Ranjan Misra, Pavitra Baskaran, and Neeta Mohanty. "Oral erythroplakia harbouring a squamous cell carcinoma." BMJ Case Reports 15, no. 2 (2022): e247983. http://dx.doi.org/10.1136/bcr-2021-247983.

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10

Panwar, SK, and A. Bitharia. "Precancerous Oral Lesions: A Review." Journal of Oral Health and Community Dentistry 7, no. 2 (2013): 119–26. http://dx.doi.org/10.5005/johcd-7-2-119.

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ABSTRACT This article reviews the different types of oral lesions and factors associated with the development of premalignant (leukoplakia and erythroplakia) and actual cancerous lesions. Diagnostic tools and aids to diagnosis are discussed, as are treatment modalities. Early detections of these lesions could save lives.

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11

Motelica, Cristinela, Gabriela Motelica, Irina Ciochina, et al. "Oral potentially malignant disorders: leukoplakia, erythroplakia, oral submucosal fibrosis. Systematic review of associated risk factors." Journal of Stomatological Medicine, no. 2 (November 2024): 36–42. https://doi.org/10.53530/1857-1328.24.2.04.

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Introduction. Oral potentially malignant disorders (OPMD) represent a heterogeneous group of oral mucosal disorders associated with an increased risk of malignant transformation. The specialty literature indicates that tobacco consumption in various forms, such as smoking products containing tobacco, reverse smoking, chewing tobacco, alcohol consumption, consumption of areca (betel) nuts, are the factors most often involved in the development of OPMD. The aim of the study. Systematic review of scientific researches and clinical trials on risk factors involved in the development of leukoplakia,

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12

Aslam, Sidra, and Sarah Ghafoor. "Insulin-like growth factor-I signaling plays a pivotal role in the development of oral premalignant lesions in patients with diabetes mellitus." BioMedica 38, no. 3 (2022): 129–33. http://dx.doi.org/10.51441/biomedica/5-759.

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<p>Diabetes mellitus is a disorder of the metabolic system that is diagnosed by hyperglycemia and glucose intolerance. Diabetic patients are frequently prone to developing oral health complications, such as being at a higher risk for developing oral precancerous conditions like lichen planus, leukoplakia, and erythroplakia. Insulin-like growth factor-I (IGF-I) is a peptide hormone with a structure similar to insulin and belongs to the family of growth factors that play a vital role in the development of embryonic, postembryonic, and normal physiological functions of the human body. IGF-I

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13

Tarle, Marko, Marina Raguž, Danko Muller, and Ivica Lukšić. "Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma." International Journal of Molecular Sciences 24, no. 6 (2023): 5816. http://dx.doi.org/10.3390/ijms24065816.

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The aim of this study was to determine, by immunohistochemical methods, the expression of nEGFR and markers of cell proliferation (Ki-67), cell cycle (mEGFR, p53, cyclin D1), and tumor stem cells (ABCG2) in 59 pathohistological samples of healthy oral mucosa, 50 oral premalignant changes (leukoplakia and erythroplakia), and 52 oral squamous cell carcinomas (OSCC). An increase in the expression of mEGFR and nEGFR was found with the development of the disease (p < 0.0001). In the group of patients with leukoplakia and erythroplakia, we found a positive correlation between nEGFR and Ki67, p53,

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14

Villa, A., C. Villa, and S. Abati. "Oral cancer and oral erythroplakia: an update and implication for clinicians." Australian Dental Journal 56, no. 3 (2011): 253–56. http://dx.doi.org/10.1111/j.1834-7819.2011.01337.x.

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15

Goswami, Arunima, Bharadwaj Bordoloi, Pinky Goswami, and Aanchal Tandon. "Efficacy of Photodynamic Therapy in the Treatment of Oral Premalignant Lesions: A Systematic Review." Journal of Primary Care Dentistry and Oral Health 4, no. 3 (2023): 64–70. http://dx.doi.org/10.4103/jpcdoh.jpcdoh_18_23.

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Abstract Photodynamic therapy (PDT) is considered a contemporary effective treatment option for oral premalignant lesions. This systematic review aims to evaluate the usefulness of PDT for the treatment of oral premalignant lesions. The focused question was “Is PDT effective in the treatment of oral premalignant lesions?” A literature search was made in PubMed/Medline and Google Scholar databases using different combinations of the following keywords: photodynamic therapy, oral premalignant lesions, oral leukoplakia (OL), erythroplakia, oral erythroleukoplakia (OEL), oral verrucous hyperplasia

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16

Chairman, T. Axéll, and M. C. Downer. "Early Diagnosis and Prevention of Oral Cancer and Precancer: Report of Symposium III." Advances in Dental Research 9, no. 2 (1995): 134–37. http://dx.doi.org/10.1177/08959374950090021301.

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Oral precancer encompasses several conditions and lesions. Among those entities included in the concept are leukoplakia, erythroplakia, lichen planus, and submucous fibrosis. For prevention, knowledge about etiologic and pathogenetic factors is imperative. It is well-known that excessive consumption of tobacco and alcohol has a bearing on the development of oral leukoplakia and probably also of erythroplakia. However, among leukoplakias, the idiopathic or cryptogenic type probably shows the most serious malignant potential. Involved in the development of such lesions may be general nutritional

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17

Bhattacharyya, S. "Oral Premalignant Lesions and Infections." General Medicine and Clinical Practice 7, no. 12 (2024): 01–04. https://doi.org/10.31579/2639-4162/197.

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Precancerous lesions of the oral mucosa, consists of a group of diseases, which should be diagnosed in an early stage. Oral leukoplakia, oral submucous fibrosis, erythroplakia are among the most common oral diseases having a high malignant transformation rate. Oral lesions, and viral infections (eg. HPV) are early signs of oral precancerous diseases even leading to squamous cell carcinoma. All doctors, dental surgeons, and especially dermatologists are encouraged to perform an accurate oral examination of all suspected cases to recognize the disease in its early stage.

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18

Hamao, Aya, Masakatsu Fukuda, Akio Tanaka, et al. "A Case of Extensive Erythroplakia in the Oral Mucosa." Oral Medicine & Pathology 7, no. 1 (2002): 47–51. http://dx.doi.org/10.3353/omp.7.47.

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19

Aastha Jain and Bhuvan Sharma. "The Prevalence and Risk Factors for Potential Oral Malignant Disorders in a Middle Aged North Indian Population." International Healthcare Research Journal 3, no. 3 (2019): 123–27. http://dx.doi.org/10.26440/ihrj/0303.06247.

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INTRODUCTION: The menace of oral cancer has become a public health concern and its prevalence is increasing with every passing day, making it the sixth most common cancer across the globe. OBJECTIVE: To evaluate the prevalence and risk factors for potential oral malignant disorders in a middle aged north Indian population. MATERIALS AND METHODS: This Cross-sectional study was carried out on 1260 individuals in Delhi and NCR. A questionnaire was created to record information about socio demographic traits, oral hygiene routines, threat associated to oral probable malignant disorders

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20

Kumar, Randhir, Geeta Sharma, Meenu Taneja Bhasin, and Atul Anand Bajoria. "Clinico-pathological analysis of oral red and white mucosal lesions in iron-deficiency anemia among non-tobacco-users." Bioinformation 21, no. 05 (2025): 973–77. https://doi.org/10.6026/973206300210973.

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The relation between hematological parameters and the presence of oral red and white mucosal lesions among non-tobacco-using adults diagnosed with iron-deficiency anemia is of interest. Hematological parameters, including hemoglobin, serum ferritin, MCV, MCH and RDW, were recorded. Clinical oral examinations identified red (erythroplakia, atrophic glossitis) and white lesions (oral candidiasis, leukoplakia-like patches and angularcheilitis). There was a significant association between iron-deficiency anemia and specific oral mucosal lesions among non-tobacco-using adults. Screening for oral ma

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21

Waris, Sadaf, Atika Masood, Rabia Safdar, Khurshid Ali, Abdur Rehman, and Nadia Wali. "CLINICAL AND CYTOLOGICAL EVALUATION OF ORAL MUCOSAL LESIONS IN PAN-CHEWERS FROM LAHORE, PAKISTAN." Journal of Akhtar Saeed Medical & Dental College 01, no. 02 (2019): 45–50. https://doi.org/10.51127/jamdcv01i02oa01.

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Objective: The current study was performed to asses demographic, clinical and cyto-morphological features of oral mucosa in pan chewers. Methods:This was a cross-sectional, survey. After taking relevant historyand informed consent, a clinical examination was performed on300 pan usersfrom Lahore city. Cytological smears were obtained to be stained withHaematoxylin and Eosin, Giemsa and Pap’s stain. All the smears were examined under light microscope to evaluatecyto-morphological changes. Data wereanalyzed with the help of SPSS. Results:The average age for allsubjects was 32.28±0.59 and 95% were

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Aastha, Jain, and Sharma Bhuvan. "The Prevalence and Risk Factors for Potential Oral Malignant Disorders in a Middle Aged North Indian Population." International Healthcare Research Journal 3, no. 3 (2019): 123–27. https://doi.org/10.26440/IHRJ/0303.06247.

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<strong>INTRODUCTION: </strong>The menace of oral cancer has become a public health concern and its prevalence is increasing with every passing day, making it the sixth most common cancer across the globe. <strong>OBJECTIVE:</strong> To evaluate the prevalence and risk factors for potential oral malignant  disorders in a middle aged north Indian population. <strong>MATERIALS AND METHODS: </strong>This Cross-sectional study was carried out on 1260 individuals in Delhi and NCR. A questionnaire was created to record information about socio demographic traits, oral hygiene routines, threat as

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23

Feng, Jin-Qiu, Jun-Guo Mi, Lan Wu, et al. "Expression of podoplanin and ABCG2 in oral erythroplakia correlate with oral cancer development." Oral Oncology 48, no. 9 (2012): 848–52. http://dx.doi.org/10.1016/j.oraloncology.2012.03.015.

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24

Hosni, Elaini Sickert, Fernanda Gonçalves Salum, Karen Cherubini, Liliane Soares Yurgel, and Maria Antonia Zancanaro Figueiredo. "Oral Erythroplakia and Speckled Leukoplakia: retrospective analysis of 13 cases." Brazilian Journal of Otorhinolaryngology 75, no. 2 (2009): 295–99. http://dx.doi.org/10.1016/s1808-8694(15)30793-x.

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25

Roza, Ana Luiza Oliveira Corrêa, Luiz Paulo Kowalski, William Nassib William, et al. "Oral leukoplakia and erythroplakia in young patients: a systematic review." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 131, no. 1 (2021): 73–84. http://dx.doi.org/10.1016/j.oooo.2020.09.002.

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Shoorgashti, R., A. Moshiri, and S. Lesan. "Evaluation of Oral Mucosal Lesions in Iranian Smokers and Non-smokers." Nigerian Journal of Clinical Practice 27, no. 4 (2024): 467–74. http://dx.doi.org/10.4103/njcp.njcp_702_23.

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ABSTRACT Background: Tobacco smoking statistics are alarming and the oral mucosa is the first human part of the body that is exposed to the toxic substances of smoking. Aims: Considering the high prevalence rate of tobacco-associated problems in the oral cavity and few studies on the Iranian population regarding the effects of smoking on the oral cavity, this study aimed to evaluate the relationship between smoking and oral lesions in the Iranian population. Materials and Methods: Observational study. In this observational study, the oral cavities of 200 participants (smokers = 100 and non-smo

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Jerjes, Waseem, T. Upile, B. Conn, et al. "Oral leukoplakia and erythroplakia subjected to optical coherence tomography: preliminary results." British Journal of Oral and Maxillofacial Surgery 46, no. 7 (2008): e7. http://dx.doi.org/10.1016/j.bjoms.2008.07.108.

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Qin, Guo-Zhong, Jong Y. Park, Sow-Yeh Chen, and Philip Lazarus. "A high prevalence of p53 mutations in pre-malignant oral erythroplakia." International Journal of Cancer 80, no. 3 (1999): 345–48. http://dx.doi.org/10.1002/(sici)1097-0215(19990129)80:3<345::aid-ijc2>3.0.co;2-n.

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Hanumakonda, Soundarya, Marri Swetha, Mallela Bhashitha, and Harsha Mudigonda. "A clinical study on precancerous lesions of oral cavity in patients attending dental hospital, Telangana." International Journal Of Community Medicine And Public Health 6, no. 11 (2019): 4739. http://dx.doi.org/10.18203/2394-6040.ijcmph20195048.

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Background: Aim of the retrospective study is to determine the type and frequency of the precancerous lesions of the oral cavity and to assess their sex, age distribution among the patients.Methods: Study was conducted based on year-wise data collected during 2015 to 2018 of all the patients with precancerous lesions of oral cavity.Results: The total number of patients was 1247, out of which 803 (64.39%) were males and 444 (35.60%) were females. Most common precancerous lesion is oral submucous fibrosis (70.24%) followed by oral lichen planus (19.08%), leukoplakia (8.98%), erythroplakia (1.68%

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30

Kanwar, Santosh, Nishath Khanum, M. S. Mahesh, Archana Patil, and Khairunnisa. "A comparative evaluation of colposcopy and biopsy in the diagnosis of oral pre-malignant lesions and conditions, and oral carcinoma - An in vivo study." Indian Journal of Cancer 61, no. 3 (2024): 484–89. https://doi.org/10.4103/ijc.ijc_758_22.

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Abstract Background: Early detection of premalignant lesions and conditions leads to timely intervention and prevention of serious consequences such as oral carcinoma, thereby improving the quality of care to the patients. The aim of our study was to determine the vascular patterns and compare the biopsy obtained by clinical examination and colposcopic criteria by histopathological examination. Methods: Sixty subjects with oral submucous fibrosis, leukoplakia, lichen planus, erythroplakia, and carcinoma of buccal mucosa were selected based on the inclusion and exclusion criteria set forth for

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31

Madiyal, Ananya, Vidya Ajila, Subhas G. Babu, Shruthi Hedge, Harini Keshavaiah, and Priyadharshini Alva M. "ROLE OF PHYTOCHEMICALS IN ORAL POTENTIALLY MALIGNANT DISORDERS : A REVIEW." Journal of Health and Allied Sciences NU 04, no. 04 (2014): 120–25. http://dx.doi.org/10.1055/s-0040-1703850.

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AbstractOral cancer is a major global health concern and poses a challenge to diagnostic and therapeutic aspects of healthcare services. Various oral lesions like leukoplakia, erythroplakia, lichen planus and oral submucus fibrosis categorized as orally potential malignant disorders have shown increased incidence of malignant transformation. Free radicals are highly reactive chemical species with capacity to damage nucleic acids, proteins and lipids and bring about changes of clinical significance. Antioxidants help in scavenging these free radicals and prevent disease progression. Naturally o

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32

SONONE, ARCHANA. "Estimation Of Alkaline Phosphatase In Oral Squamous Cell Carcinoma Patient." DMIMS Journal of Dental Research 6, no. 4 (2022): 143–46. http://dx.doi.org/10.54054/jodr.2022645.

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Oral squamous cell carcinoma (OSCC) is one of the life threatening and mutilating disease affecting the mankind. Most invasive OSCC are preceded by clinical premalignant lesions and conditions such as oral leukoplakia, erythroplakia, oral lichen planus, and oral submucous fibrosis (OSMF). These remain in preinvasive stage for years and the cancerous alterations remain indolent and not readily recognizable on clinical and histopathologic examination. There are various biological markers which can be used to monitor progression of precancerous lesions to cancer, predict the therapeutic response

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33

Swain, Santosh Kumar. "Premalignant lesions of the oral cavity: current perspectives." International Journal of Research in Medical Sciences 9, no. 6 (2021): 1816. http://dx.doi.org/10.18203/2320-6012.ijrms20212259.

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Premalignant lesions of the oral cavity are also called as potentially malignant disorders. The common premalignant lesions of the oral cavity include leukoplakia, oral submucous fibrosis (OSMF) and oral erythroplakia. These lesions have a very high malignant transformation rate. The exact etiological factors for development of the premalignant lesions of the oral cavity are not fully understood till date. Use of tobacco, alcohol drinking, chewing betel quid containing areca nut and solar rays are important etiological factors for resulting the premalignant lesions of the oral cavity. Early di

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34

Foy, Jean-Philippe, Chloé Bertolus, Patrick Goudot, et al. "Bibliometric analysis of a century of research on oral erythroplakia and leukoplakia." Journal of Oral Pathology & Medicine 47, no. 4 (2018): 388–95. http://dx.doi.org/10.1111/jop.12683.

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Yang, Xi, and Wei Liu. "Bibliometric analysis of the top‐cited articles on oral erythroplakia and leukoplakia." Journal of Oral Pathology & Medicine 48, no. 6 (2019): 505–6. http://dx.doi.org/10.1111/jop.12863.

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Tan, Neil C. W., Tim Mellor, Peter A. Brennan, and Roberto Puxeddu. "Use of narrow band imaging guidance in the management of oral erythroplakia." British Journal of Oral and Maxillofacial Surgery 49, no. 6 (2011): 488–90. http://dx.doi.org/10.1016/j.bjoms.2010.09.001.

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37

Shi, Linjun, Wen Jiang, and Wei Liu. "Retrospective analysis of oral erythroplakia focused on multiple and multifocal malignant behavior." Oral Diseases 25, no. 7 (2019): 1829–30. http://dx.doi.org/10.1111/odi.13144.

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Shaikh, Mushfiq Hassan, Md Ashif Iqbal, and SM Anwar Sadat. "Oral Potentially Malignant Disorders: A review on Bangladesh perspective." Journal of Bangladesh College of Physicians and Surgeons 41, no. 4 (2023): 305–14. http://dx.doi.org/10.3329/jbcps.v41i4.66936.

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Oral potentially malignant disorders (OPMDs) are a group of chronic conditions affecting the oral mucosa with a risk of transformation to oral squamous cell carcinoma (OSCC). Oral leukoplakia, oral submucous fibrosis, oral lichen planus, and oral erythroplakia are the most common OPMDs observed in South Asian population. However, oral leukoplakia and oral lichen planus are commonly encountered OPMDs in clinical practice in Bangladesh, possibly, owing to specific lifestyle habits. Although the exact aetiology is unknown, use of smokeless tobacco, smoking, and chewing of betel quid containing ar

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Jayasinghe, Ruwan Duminda, and B. S. M. S. Siriwardena. "Clinical Aspects of Oral Cancer and Potentially Malignant Disorders with Special Relevance to South Asia." Annals of Maxillofacial Surgery 14, no. 2 (2024): 128–36. https://doi.org/10.4103/ams.ams_184_24.

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Abstract Early identification of oral potentially malignant disorders (OPMDs) is utmost important to minimise oral cancer incidence as most oral cancers develop from OPMDs. Leucoplakia and oral submucous fibrosis (OSMF) are the most common OPMDs encountered. Erythroplakia is rare but is more serious as it has a very high malignant transformation rate. Clinical presentation of OPMDs can vary according to the type of the disorder as well as with the aetiological agents. OSMF is much prevalent in South and South Asian countries whereas leucoplakia is prevalent all over the world but with differen

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Azevedo, Alexandro Barbosa, Teresa Cristina Ribeiro Bartholomeu Santos, Márcio Ajudarte Lopes, and Fábio Ramoa Pires. "Oral leukoplakia, leukoerythroplakia, erythroplakia and actinic cheilitis: Analysis of 953 patients focusing on oral epithelial dysplasia." Journal of Oral Pathology & Medicine 50, no. 8 (2021): 829–40. http://dx.doi.org/10.1111/jop.13183.

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Moisa, Mihai Radu, Elena Claudia Coculescu, Marina Imre, Alexandra Ripszky, Bogdan-Ioan Coculescu, and Silviu Mirel Pituru. "PI3K/AKT/MTOR SIGNALING PATHWAY – A KEY PLAYER IN THE MOLECULAR LANDSCAPE OF MALIGNANT TRANSFORMATION OF ORAL LESIONS." Romanian Journal of Oral Rehabilitation 16, no. 2 (2024): 214–24. https://doi.org/10.62610/rjor.2024.2.16.21.

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Aberrant PI3K/AKT/mTOR/ pathway have been considered one of the starting points of various types of human cancer, including the oral squamous cell carcinoma (OSCC). The important role played by this signaling pathway in oncogenesis and cancer evolution, oriented the researchers’ attention toward studies of AKT and the PI3K/AKT/mTOR axis in the context of malignant transformation of oral precancerous lesions. Consequently, this article’s aim is an update of the possible key role played by the PI3K /AKT/mTOR axis on the oral lesions’ malignant transformation stage. Oral potentially malignant dis

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Pandey, Ashutosh. "Cryotherapy for oral potentially malignant disorders." Bioinformation 19, no. 13 (2023): 1377–82. http://dx.doi.org/10.6026/973206300191377.

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Four surgical treatment modalities namely cryosurgery, scalpel and blade surgery, diode LASER surgery and CO2 LASER surgery in the management of oral potentially malignant disorders (OPMDs) in terms of healing outcomes post operatively and recurrence is evaluated. The study included sixty outpatients whose biopsies revealed OPMDs (oral lichen planus, homogeneous leukoplakia, non-homogenous leukoplakia and erythroplakia). There is decrease in post-operative pain and oedema in all four treatment categories at one week follow up and two week follow up. It was observed that pain was low in cryosur

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Kaya, Sebahat, Christian Walter, Aya Khamis, et al. "The Effect of Oral Potentially Malignant Disorders (OPMD) on Dental Implants Survival—A Systematic Review." Dentistry Journal 13, no. 1 (2025): 35. https://doi.org/10.3390/dj13010035.

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Objectives: This research is purposed to synthesize the existing evidence on implant survival rates in patients with oral potentially malignant disorders (OPMD) and assess potential risk factors associated with peri-implant disease. Material and Methods: A comprehensive search was performed across PubMed MEDLINE, Cochrane Library, and Web of Science. This review was conducted according to the PRISMA guidelines, including studies published between 2012 and 2023. Results: The review of studies related to oral lichen planus (OLP) revealed an implant survival rate of 99.3% (50% to 100%) with a mea

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Cirillo, Nicola. "Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review." Cancers 16, no. 8 (2024): 1550. http://dx.doi.org/10.3390/cancers16081550.

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Despite the profession placing great emphasis on oral potentially malignant disorders (OPMDs) as a gateway for early recognition and consequently better outcomes for oral cancer, the death rates for lip and oral cavity cancer have remained stagnant for three decades. Evidence shows that only a small fraction of oral cancers are in fact preceded by OPMDs, and that most OPMDs have an annual transformation rate of less than 1%. As OPMDs encompass a very heterogeneous group of oral conditions, it could be argued that only patients with oral mucosal diseases bearing a substantial risk of malignant

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Görürgöz, Cansu, Nilsu Sakalli, Ferah Mutlu Kul, and Nurhan Uslu Özalp. "Ultrasonographic Evaluation of Maxillofacial Swelling in a Pediatric Patient with Xeroderma Pigmentosum." Balkan Journal of Dental Medicine 23, no. 3 (2019): 163–66. http://dx.doi.org/10.2478/bjdm-2019-0029.

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Summary Background/Aim: Xeroderma pigmentosum (XP) is an autosomal recessive skin disease. Affected patients have skin problems, oral mucosa and neurologic symptoms. In these patients, erythematous, hyperpigmented or malignant skin lesions may occur in the sun-exposed areas. Leukoplakia, erythroplakia, and squamous cell carcinoma of the tip of the tongue and lips are common oral lesions associated with XP. Case report: Treatment of the disease included protection from ultraviolet radiation, topical application to treat actinic keratitis, and multidisciplinary approaches by physicians. Conclusi

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Feng, Jin-Qiu, Zi-Yuan Xu, Lin-Jun Shi, Lan Wu, Wei Liu, and Zeng-Tong Zhou. "Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer." Journal of Oral Pathology & Medicine 42, no. 2 (2012): 148–53. http://dx.doi.org/10.1111/j.1600-0714.2012.01191.x.

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DAWOOD, DJ, and AE PARASHOS. "PREVALENCE OF ORAL MUCOSAL LESIONS IN TOBACCO AND ALCOHOL USERS: A RETROSPECTIVE ANALYSIS USING VELSCOPE." International Journal of Medical Science and Dental Health 11, no. 04 (2025): 01–06. https://doi.org/10.55640/ijmsdh-11-04-01.

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Background: Tobacco and alcohol consumption are major risk factors for oral mucosal lesions (OMLs), which may precede malignant transformation. Early detection using advanced diagnostic tools like VELscope can improve outcomes. This study aimed to assess the prevalence of OMLs in tobacco and alcohol users using VELscope. Methods: A retrospective analysis was conducted on 450 patients with a history of tobacco and/or alcohol use. VELscope examination was performed to detect OMLs, and findings were correlated with habit duration and intensity. Results: The prevalence of OMLs was 68% in tobacco u

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HONMA, Yoshiro, Kenji KAWAHARA, Satoshi INOUE, et al. "A Multiple Oral Carcinoma Arising in a Massive Erythroplakia Patient: Report of a Case." Journal of Japanese Society for Oral Mucous Membrane 9, no. 1 (2003): 34–39. http://dx.doi.org/10.6014/jjomm1995.9.34.

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Kumar, Sandeep, Nitai Debnath, Mohammed B. Ismail, et al. "Prevalence and Risk Factors for Oral Potentially Malignant Disorders in Indian Population." Advances in Preventive Medicine 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/208519.

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Objective. To assess the prevalence of oral potentially malignant disorders and to determine the potential risk factors for its development in Indian population.Materials and Methods. This cross-sectional study was carried out on 1241 individuals in Indore, Madhya Pradesh. A questionnaire was designed to record information about sociodemographic characteristics, oral hygiene practices, dietary habits, and risk factors for oral potentially malignant disorders. Oral mucosal lesions were examined by a skilled person.Results. The overall prevalence of oral potentially malignant disorders was found

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Yadav, Manisha, Vipin Arora, Showket Hussain, et al. "Evaluation of extracellular signal regulated kinase 1 expression in premalignant lesions of oral cavity." International Surgery Journal 7, no. 12 (2020): 3965. http://dx.doi.org/10.18203/2349-2902.isj20204978.

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Background: Most oral squamous cell carcinomas are preceded by premalignant lesions like leukoplakia, erythroplakia etc. Identification of these lesions by molecular markers and intervention at an early stage can reduce mortality, morbidity and cost of treatment associated with oral cancer. Extracellular signal regulated kinase 1 (ERK 1) is one of the various markers involved in carcinogenesis.Methods: We studied the expression of ERK 1 in twenty-five oral premalignant lesion biopsies using immunohistochemistry (IHC) and western blot analysis.Results: Ninety-two percent of premalignant lesions

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