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Journal articles on the topic 'Oral homeostasis'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Wallet, Shannon. "TLR2 Regulation of Oral Keratinocyte Driven Mucosal Homeostasis in the Context of Diabetes Mellitus (47.11)." Journal of Immunology 184, no. 1_Supplement (2010): 47.11. http://dx.doi.org/10.4049/jimmunol.184.supp.47.11.

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Abstract Oral epithelium contributes to innate immunity and plays an important role in immune tolerance/homeostasis. Disruption of this homeostasis can result in initiation and/or exacerbation of localized inflammation that secondarily causes/worsens systemic diseases. Toll-like receptor 2 (TLR2) is one molecular pattern receptor that under cell- and/or environment-specific conditions can induce either inflammatory or regulatory immune responses. Hyperglycemia, a sequela of diabetes mellitus, has multiple profound effects on the local innate responses, which drives cyclical pathogenesis where

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2

Tomi Kupka, Tomasz. "Oral homeostasis, kill the microbiome or not?" Journal of Applied Biotechnology & Bioengineering 6, no. 2 (2019): 49–55. http://dx.doi.org/10.15406/jabb.2019.06.00174.

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The objective is to short review the current state of the art of dental antimicrobial agents in term of minimal invasive restorative dentistry. An outline of the most important aspects of dental antimicrobial agents was created, and a subsequent literature search for articles related was conducted. The current state of the art of antimicrobial agents includes a variety of species with broad ranges of properties. There is no agreement as to the choice of substances and concentration, however, there is a growing consensus regarding the need to use antimicrobial agents as additions into dental re

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Cortés-Vieyra, Ricarda, Carlos Rosales, and Eileen Uribe-Querol. "Neutrophil Functions in Periodontal Homeostasis." Journal of Immunology Research 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/1396106.

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Oral tissues are constantly exposed to damage from the mechanical effort of eating and to microorganisms, mostly bacteria. In healthy gingiva tissue remodeling and a balance between bacteria and innate immune cells are maintained. However, excess of bacteria biofilm (plaque) creates an inflammation state that recruits more immune cells, mainly neutrophils to the gingiva. Neutrophils create a barrier for bacteria to reach inside tissues. When neutrophils are insufficient, bacteria thrive causing more inflammation that has been associated with systemic effects on other conditions such as atheros

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4

Borowiec, Blanka, Sylwia Ciesiółka, Krzysztof Janowicz, et al. "The processes of homeostasis, chemotaxis and organic and inorganic response are significantly up-regulated during short-term oral mucosal cells in vitro cultivation." Medical Journal of Cell Biology 8, no. 1 (2020): 50–59. http://dx.doi.org/10.2478/acb-2020-0006.

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AbstractMucous membranes appear in various parts of the whole body performing similar functions. However, they differ based on where the mucosa is located. It functions as a barrier in such systems as: respiratory, urogenital and digestive . In this study we will be focusing strictly on the oral mucosa. Keratinocytes and fibroblasts, which mainly form the structure of the oral mucosa, are subjected to numerous factors. Being one of the million parts that build the animal organism, they are involved in various processes. In this study, we will try to confirm that in the in vitro culture of oral

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Nassar, Maria, Yaara Tabib, Tal Capucha, et al. "GAS6 is a key homeostatic immunological regulator of host–commensal interactions in the oral mucosa." Proceedings of the National Academy of Sciences 114, no. 3 (2017): E337—E346. http://dx.doi.org/10.1073/pnas.1614926114.

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The oral epithelium contributes to innate immunity and oral mucosal homeostasis, which is critical for preventing local inflammation and the associated adverse systemic conditions. Nevertheless, the mechanisms by which the oral epithelium maintains homeostasis are poorly understood. Here, we studied the role of growth arrest specific 6 (GAS6), a ligand of the TYRO3–AXL–MERTK (TAM) receptor family, in regulating oral mucosal homeostasis. Expression of GAS6 was restricted to the outer layers of the oral epithelium. In contrast to protein S, the other TAM ligand, which was constitutively expresse

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6

Nagai, Motoyoshi, Takuma Okawa, Kazuaki Nakata, Yuki I. Kawamura, and Koji Hase. "Nutritional factors govern gut homeostasis via oral tolerance." Journal of Immunology 210, no. 1_Supplement (2023): 153.06. http://dx.doi.org/10.4049/jimmunol.210.supp.153.06.

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Abstract Oral tolerance is one of the most critical systems to regulate allergic disorders. However, how dietary factors regulate the induction and maintenance of oral tolerance remains to be elucidated. To address this, we temporarily omitted the food supply by fasting before oral ovalbumin (OVA) administration. We observed that fasting mitigated the expansion of OVA-specific Treg cells. This abnormality mainly resulted from functional defects in CX3CR1 highmacrophages responsible for the uptake of luminal OVA and the reduction of tolerogenic CD103 +dendritic cells (DCs). Eventually, fasting

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7

Honey, Nafzia, and Niroshini Rajaram. "The Dynamic Role Of Myofibroblasts In Oral Tissue Homeostasis And Disease." International Journal of Histopathological Interpretation 13, no. 1 (2024): 11–16. http://dx.doi.org/10.56501/intjhistopatholinterpret.v13i1.1047.

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Myofibroblasts are specialized cells that play a crucial role in maintaining the structural integrity and function of oral tissues. These cells exhibit a unique phenotype marked by the expression of alpha-smooth muscle actin (α-SMA), and possess the ability to contract and produce extracellular matrix components. In healthy oral tissues, myofibroblasts contribute to tissue homeostasis by mediating wound healing, tissue remodeling, and matrix turnover. However, the dysregulation of myofibroblast function can lead to pathological conditions such as fibrosis, scarring, and oral cancer. This revie

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8

Wallet, Shannon, Tess Alonso, Charles Lalane, Dana Catalfamo, and Kathleen Neiva. "Altered oral mucosal homeostasis in Type 1 diabetes (162.19)." Journal of Immunology 186, no. 1_Supplement (2011): 162.19. http://dx.doi.org/10.4049/jimmunol.186.supp.162.19.

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Abstract In type 1 diabetes (T1D) alterations in mucosal barrier function and immunity are implicated in disease pathogenesis. We have reported that TLR2-inducing homeostatic responses are disrupted in oral epithelial cells (HOK) from T1D individuals. The objective of the study was to delineate mechanisms of TLR2-induced homeostasis altered in T1D. miRNA, protein phosphorylation and cytokine expression were evaluated in HOK challenged with TLR2 or TLR4 agonists. Expression of cytokines was evaluated using a multiplex assay. Total RNA was probed for miR146a, mir133, miR9 and miR155 using qPCR.

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9

Mandel, Irwin D. "The role of saliva in maintaining oral homeostasis." Journal of the American Dental Association 119, no. 2 (1989): 298–304. http://dx.doi.org/10.14219/jada.archive.1989.0211.

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10

Vacek, Jan. "Role of electrophiles in oral cavity redox homeostasis." Free Radical Biology and Medicine 233 (June 2025): S58. https://doi.org/10.1016/j.freeradbiomed.2025.05.204.

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11

MURTAZAEV, Saidmurodkhon Saidalоyevich, and Farizakhon Rasulovna DZHALILOVA. "CORRECTION OF PHYSICAL AND CHEMICAL PROPERTIES AND BIOELEMENTAL HOMEOSTASIS OF ORAL FLUID IN CHILDREN OF ARTIFICIAL FEEDING." Journal of biomedicine and practice 7, no. 5 (2022): 4. https://doi.org/10.5281/zenodo.7392892.

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The results of studies of the initial level of dental status, physical and chemical properties, as well as bioelemental homeostasis of the oral fluid of artificially fed children are presented. The analysis of macro- and microelement compositions of various types of natural milk was carried out. The possibilities of correcting the physicochemical properties and cariogenic bioelemental homeostasis of the oral fluid were studied by using appropriate types of natural milk with a periodic assessment of the dynamics of changes in the dental status of the examined children. As a result of the resear

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12

Guo, Yuanyuan, Zhiquan Li, Feng Chen, and Yujuan Chai. "Polyphenols in Oral Health: Homeostasis Maintenance, Disease Prevention, and Therapeutic Applications." Nutrients 15, no. 20 (2023): 4384. http://dx.doi.org/10.3390/nu15204384.

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Polyphenols, a class of bioactive compounds with phenolic structures, are abundant in human diets. They have gained attention in biomedical fields due to their beneficial properties, including antioxidant, antibacterial, and anti-inflammatory activities. Therefore, polyphenols can prevent multiple chronic or infectious diseases and may help in the prevention of oral diseases. Oral health is crucial to our well-being, and maintaining a healthy oral microbiome is essential for preventing various dental and systemic diseases. However, the mechanisms by which polyphenols modulate the oral microbio

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Čižmárová, Beáta, Vladimíra Tomečková, Beáta Hubková, Anna Hurajtová, Jana Ohlasová, and Anna Birková. "Salivary Redox Homeostasis in Human Health and Disease." International Journal of Molecular Sciences 23, no. 17 (2022): 10076. http://dx.doi.org/10.3390/ijms231710076.

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Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathological conditions caused by oxidative stress. In our work, we discuss redox homeostasis and salivary antioxidant activity during healthy periods and in periods of disease: dental carries, oral cavity cancer, periodontal diseases, cardiovascular diseases, diabetes mellitus, systemic sclerosis, and pa

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14

Allen Neece, J. "Skeletal malocclusion: Homeostasis or pathology?" Journal of Oral and Maxillofacial Surgery 45, no. 1 (1987): 2. http://dx.doi.org/10.1016/0278-2391(87)90076-0.

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15

Agnello, M., L. Cen, N. C. Tran, W. Shi, J. S. McLean, and X. He. "Arginine Improves pH Homeostasis via Metabolism and Microbiome Modulation." Journal of Dental Research 96, no. 8 (2017): 924–30. http://dx.doi.org/10.1177/0022034517707512.

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Dental caries can be described as a dysbiosis of the oral microbial community, in which acidogenic, aciduric, and acid-adapted bacterial species promote a pathogenic environment, leading to demineralization. Alkali generation by oral microbes, specifically via arginine catabolic pathways, is an essential factor in maintaining plaque pH homeostasis. There is evidence that the use of arginine in dentifrices helps protect against caries. The aim of the current study was to investigate the mechanistic and ecological effect of arginine treatment on the oral microbiome and its regulation of pH dynam

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16

Tokajuk, Joanna, Piotr Deptuła, Ewelina Piktel, et al. "Cathelicidin LL-37 in Health and Diseases of the Oral Cavity." Biomedicines 10, no. 5 (2022): 1086. http://dx.doi.org/10.3390/biomedicines10051086.

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The mechanisms for maintaining oral cavity homeostasis are subject to the constant influence of many environmental factors, including various chemicals and microorganisms. Most of them act directly on the oral mucosa, which is the mechanical and immune barrier of the oral cavity, and such interaction might lead to the development of various oral pathologies and systemic diseases. Two important players in maintaining oral health or developing oral pathology are the oral microbiota and various immune molecules that are involved in controlling its quantitative and qualitative composition. The LL-

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17

Chen, Xiuqin, Eric Banan-Mwine Daliri, Akanksha Tyagi, and Deog-Hwan Oh. "Cariogenic Biofilm: Pathology-Related Phenotypes and Targeted Therapy." Microorganisms 9, no. 6 (2021): 1311. http://dx.doi.org/10.3390/microorganisms9061311.

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The initiation and development of cariogenic (that is, caries-related) biofilms are the result of the disruption of homeostasis in the oral microenvironment. There is a daily accumulation of dental biofilm on the surface of teeth and its matrix of extracellular polymers supports the host in its defense against invading microbes, thus helping to achieve oral microbial homeostasis. However, the homeostasis can be broken down under certain circumstances such as during long-term exposure to a low pH environment which results in the dominance of acidogenic and acid-tolerating species in the dental

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18

Basiri, T., N. D. Johnson, E. B. Moffa, et al. "Duplicated or Hybridized Peptide Functional Domains Promote Oral Homeostasis." Journal of Dental Research 96, no. 10 (2017): 1162–67. http://dx.doi.org/10.1177/0022034517708552.

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19

Segundo, F. Díaz-San, N. Sevilla, J. P. Gutiérrez, and A. Brun. "Altered lymphocyte homeostasis after oral prion infection in mouse." Veterinary Immunology and Immunopathology 122, no. 3-4 (2008): 204–15. http://dx.doi.org/10.1016/j.vetimm.2007.11.013.

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20

D'Erasmo, E., D. Pisani, A. Ragno, N. Raejntroph, E. Vecci, and M. Acca. "Calcium Homeostasis During Oral Glucose Load in Healthy Women." Hormone and Metabolic Research 31, no. 04 (1999): 271–73. http://dx.doi.org/10.1055/s-2007-978731.

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21

Pervov, Yu Y., V. S. Bocharov, A. R. Kim, and Galina V. Reva. "Influence of dental prostheses materials on the condition of oral mucosa local homeostasis." Perm Medical Journal 41, no. 5 (2024): 5–18. http://dx.doi.org/10.17816/pmj4155-18.

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Objective. To study the influence of base materials used in the manufacture of removable dentures on the immune homeostasis of the oral mucosa, and, as a consequence, on the clinical condition of the oral mucosa and periodontium of supporting teeth. To create fundamental principles for the development of a pathogenetically substantiated choice of basic dental materials of various chemical natures for removable prosthetics based on the analysis of the parameters of immune homeostasis of the oral mucosa. Materials and methods. 154 patients aged 40 to 85 using dentures based on acrylic, polyureth

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22

Su, Yingying, Chider Chen, Lijia Guo, Juan Du, Xiaoyan Li, and Yi Liu. "Ecological Balance of Oral Microbiota Is Required to Maintain Oral Mesenchymal Stem Cell Homeostasis." STEM CELLS 36, no. 4 (2018): 551–61. http://dx.doi.org/10.1002/stem.2762.

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23

Bai, Yuchen, Jarryd Boath, Gabrielle R. White, Uluvitike G. I. U. Kariyawasam, Camile S. Farah, and Charbel Darido. "The Balance between Differentiation and Terminal Differentiation Maintains Oral Epithelial Homeostasis." Cancers 13, no. 20 (2021): 5123. http://dx.doi.org/10.3390/cancers13205123.

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The oral epithelium is one of the fastest repairing and continuously renewing tissues. Stem cell activation within the basal layer of the oral epithelium fuels the rapid proliferation of multipotent progenitors. Stem cells first undergo asymmetric cell division that requires tightly controlled and orchestrated differentiation networks to maintain the pool of stem cells while producing progenitors fated for differentiation. Rapidly expanding progenitors subsequently commit to advanced differentiation programs towards terminal differentiation, a process that regulates the structural integrity an

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24

Mohanty, Tirthankar, Jonathan Sjögren, Fredrik Kahn, et al. "A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa." Blood 126, no. 18 (2015): 2128–37. http://dx.doi.org/10.1182/blood-2015-04-641142.

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Key Points Saliva induces bactericidal and DNase resistant NETs in the oral cavity via sialyl LewisX- L-selectin signaling. Disordered homeostasis in the oral cavity may lead to deficient saliva-mediated NETosis.

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25

Aleshkin, V. A., V. N. Tsarev, A. V. Aleshkin, et al. "Role of mucosal immunity in homeostasis of environmental niches of the oral cavity." Infekcionnye bolezni 22, no. 3 (2024): 92–104. https://doi.org/10.20953/1729-9225-2024-3-92-104.

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The objective of the presented systematic literature review is to summarize the data on the mechanisms of interaction and mutual influence of gingival microbes, mucosa-associated lymphoid tissue and epithelial barrier in maintaining homeostasis of subgingival and gingival environmental niches of the oral cavity. The interaction and mutual influence of gingival microbes, mucosa-associated lymphoid tissue and epithelial barrier maintains the immunity of barrier tissues in a state of smoldering activation and readiness for a rapid response to invasion of foreign organisms or substances. Physiolog

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26

Ouchi, Takehito, and Taneaki Nakagawa. "Tissue Regeneration and Physiological Functional Recovery in Dental and Craniofacial Fields." Biomolecules 11, no. 11 (2021): 1644. http://dx.doi.org/10.3390/biom11111644.

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27

Bryja, Artur, Marta Dyszkiewicz-Konwińska, Maurycy Jankowski, et al. "Ion homeostasis and transport are regulated by genes differentially expressed in porcine buccal pouch mucosal cells during long-term culture in vitro – a microarray approach." Medical Journal of Cell Biology 6, no. 3 (2018): 75–82. http://dx.doi.org/10.2478/acb-2018-0013.

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Abstract The oral mucosa is a compound tissue composed of several cells types, including fibroblasts and keratinocytes, that are characterized by different morphology, as well as biochemical and metabolomic properties. The oral mucosal cells are the most important factors mediated between transport and drugs delivery. The changes in cellular ion homeostasis may significantly affect the bioavailability of administrated drugs and their transport across the mucous membrane. Therefore we investigated the expression profile of genes involved in ion transport and homeostasis in porcine buccal pouch

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Hernández, Paola, María C. Sánchez, Arancha Llama-Palacios, María J. Ciudad, and Luis Collado. "Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation." Antibiotics 11, no. 7 (2022): 880. http://dx.doi.org/10.3390/antibiotics11070880.

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Bacteria in the oral cavity, including commensals and opportunistic pathogens, are organized into highly specialized sessile communities, coexisting in homeostasis with the host under healthy conditions. A dysbiotic environment during biofilm evolution, however, allows opportunistic pathogens to become the dominant species at caries-affected sites at the expense of health-associated taxa. Combining tooth brushing with dentifrices or rinses combat the onset of caries by partially removes plaque, but resulting in the biofilm remaining in an immature state with undesirables’ consequences on homeo

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Miladinović-Tasić, Nataša, Katarina Nikolić, and Kristina Arizanović. "Oral cavity protozoa relevant in the practice of dentistry." Acta stomatologica Naissi 38, no. 85 (2022): 2352–69. http://dx.doi.org/10.5937/asn2285352m.

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Introduction: Oral cavity is the colonization site of most diverse microorganisms. The homeostasis of oral microbioma is affected by numerous factors. Periodontal diseases occur as a consequence of disturbed oral microbioma homeostasis, when an inflammatory reaction occurs in the periodontal tissue. The impact of parasites on periodontal pathophysiology has not been sufficiently studied, and present and future research should hopefully answer quite a few questions concerning the issue. Aim of the paper: In the light of the present knowledge of the pathogenesis, diagnosis and epidemiology of or

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Chen, Sufang, Wei Wei, Minjie Chen, et al. "TNF signaling impacts glucagon-like peptide-1 expression and secretion." Journal of Molecular Endocrinology 61, no. 4 (2018): 153–61. http://dx.doi.org/10.1530/jme-18-0129.

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Numerous studies have implicated tumor necrosis factor α (TNFα) in the pathogenesis of type 2 diabetes. However, the role of its primary receptor, TNF receptor 1 (TNFR1), in homeostatic regulation of glucose metabolism is still controversial. In addition to TNFα, lymphotoxin α (LTα) binds to and activates TNFR1. Thus, TNFα and LTα together are known as TNF. To delineate the role of TNF signaling in glucose homeostasis, the present study ascertained how TNF signaling deficiency affects major regulatory components of glucose homeostasis. To this end, normal diet-fed male TNFR1-deficient mice (TN

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Zubeidat, Khaled, and Avi-Hai Hovav. "Shaped by the epithelium – postnatal immune mechanisms of oral homeostasis." Trends in Immunology 42, no. 7 (2021): 622–34. http://dx.doi.org/10.1016/j.it.2021.05.006.

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32

Irie, K., C. M. Novince, and R. P. Darveau. "Impact of the Oral Commensal Flora on Alveolar Bone Homeostasis." Journal of Dental Research 93, no. 8 (2014): 801–6. http://dx.doi.org/10.1177/0022034514540173.

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Tsuji, Noriko M., and Akemi Kosaka. "Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells." Trends in Immunology 29, no. 11 (2008): 532–40. http://dx.doi.org/10.1016/j.it.2008.09.002.

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Savicheva, A. M., O. V. Budilovskaya, and N. I. Tapilskaya. "Role of oral probiotic lactobacilli in maintaining vaginal microbiome homeostasis." Obstetrics and gynecology: News, Opinions, Training 11, no. 1 (2023): 33–42. http://dx.doi.org/10.33029/2303-9698-2023-11-1-33-42.

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35

Kris, Ke Shyang See2* Miew Leng Khoo2 Kishan Kannan Yogaratnam1 Wai Hong Cheang1 Amarpreet Kaur Sarjit Singh1 Low Jun Kuang1 Kalichandren Arumugam1 Khang Lyn Tan1 Romel Mario Soyza1 Hui Ying Teh1 Nik Nassyiradina Putri Binti Nik Ahmat1 Norizan Binti Hassan1 Ananyaa Sreekumar1 Joyner Lim Sue May3. "Oral Microbiome - A New Frontier In Oral and Human Health: A Literature Review." International Dentistry Journal 1, no. 2 (2024): 1–11. https://doi.org/10.5281/zenodo.14223400.

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The oral microbiome has emerged as a critical focus in understanding the interconnectedness of oral and systemic health. This microbial community, comprising bacteria, fungi, viruses, and archaea, plays a vital role in maintaining homeostasis and contributing to disease when dysbiosis occurs. Recent advances in sequencing technologies have facilitated a deeper understanding of the oral microbiome's composition, functions, and its implications for human health. This literature review highlights the role of the oral microbiome in oral diseases and systemic conditions, its potential as a diagnost

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Kuziak, Agata, Piotr Heczko, Agata Pietrzyk, and Magdalena Strus. "Iron Homeostasis Dysregulation, Oro-Gastrointestinal Microbial Inflammatory Factors, and Alzheimer’s Disease: A Narrative Review." Microorganisms 13, no. 1 (2025): 122. https://doi.org/10.3390/microorganisms13010122.

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Alzheimer’s disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder that profoundly impacts cognitive function and the nervous system. Emerging evidence highlights the pivotal roles of iron homeostasis dysregulation and microbial inflammatory factors in the oral and gut microbiome as potential contributors to the pathogenesis of AD. Iron homeostasis disruption can result in excessive intracellular iron accumulation, promoting the generation of reactive oxygen species (ROS) and oxidative damage. Additionally, inflammatory agents produced by pathogenic bacteri

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Gayathri Ganapathy and Mudiyayirakkani Muthusamy. "ORAL MICROBIOTA AND SYSTEMIC DISEASES." International Journal of Orofacial Biology 6, no. 1 (2022): 1–3. http://dx.doi.org/10.56501/intjorofacbiol.v6i1.157.

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Human oral microbiota is the ecological community of commensal, symbiotic, and pathogenic microorganisms found in the oral cavity. Oral microbiota generally exists in the form of a biofilm and plays a crucial role in maintaining oral homeostasis, protecting the oral cavity and preventing disease development. Human oral microbiota has recently become a new focus research for promoting the progress of disease diagnosis, assisting disease treatment, and developing personalized medicines. In this review, the scientific evidence supporting the association that endogenous and exogenous factors (diet

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De Sanctis, Vincenzo. "THE ICET-A RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF DISTURBANCES OF GLUCOSE HOMEOSTASIS IN THALASSEMIA MAJOR PATIENTS." Mediterranean Journal of Hematology and Infectious Diseases 8 (October 25, 2016): 2016058. http://dx.doi.org/10.4084/mjhid.2016.058.

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Iron overload in patients with thalassemia major (TM) affects glucose regulation, and is mediated by several mechanisms. These include the oxidative damage inflicted by iron on the pancreatic ß -cells and liver cells leading to pancreatic and hepatic dysfunction and insulin resistance. These disturbances have been identified by oral glucose tolerance test (OGTT), euglycemic insulin clamp, homeostatic model assessment (HOMA), intravenous glucose tolerance test (IVGT) and continuous glucose monitoring system (CGMS). A group of endocrinologists, hematologists and paediatricians, members of the In

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Lisitsyna Alexandra. "Experimental Morphology of the Salivary Glands Mechanisms of the Appearance of Hyposalivation." Texas Journal of Medical Science 15 (December 14, 2022): 66–67. http://dx.doi.org/10.62480/tjms.2022.vol15.pp66-67.

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A decrease in the functional activity of the salivary glands causes a violation of the functions of the oral fluid, the active components of which provide oral homeostasis, the integrity of the mucous membrane, periodontal and hard tissues of the teeth. Review of experimental models of hyposalivation in laboratory animals

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Lin, Sisi, Subhajit Mukherjee, Juanjuan Li, Weiliang Hou, Chao Pan, and Jinyao Liu. "Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer’s patches." Science Advances 7, no. 20 (2021): eabf0677. http://dx.doi.org/10.1126/sciadv.abf0677.

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Methods capable of maintaining gut microbiota homeostasis to prevent bacterial translocation and infection under external threats are critical for multiple facets of human health but have been rarely reported. Here, we describe the elicitation of mucosal immunity to modulate the gut microbiota by oral delivery of living probiotics into Peyer’s patches. Probiotics are individually camouflaged within a yeast membrane, on which the embedded β-glucan can facilitate the phagocytosis of microfold cells that locate in the intestinal epithelium. The delivery of probiotics into lymphoid follicles after

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Goodyear, L. J., M. F. Hirshman, E. D. Horton, and E. S. Horton. "Effect of exercise training and chronic glyburide treatment on glucose homeostasis in diabetic rats." Journal of Applied Physiology 72, no. 1 (1992): 143–48. http://dx.doi.org/10.1152/jappl.1992.72.1.143.

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Exercise training and sulfonylurea treatment, either individually or in combination, were evaluated for their effects on plasma glucose concentrations, oral glucose tolerance, and glucose clearance in the perfused hindquarter of diabetic rats. Female rats that were injected with streptozocin (45 mg/kg iv) and had plasma glucose concentrations between 11 and 25 mM were considered diabetic and divided into sedentary, glyburide-treated, exercise-trained, and glyburide-treated plus exercise-trained groups. The sedentary streptozocin-treated rats were severely diabetic, as indicated by elevated glu

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Krishnan, Siddharth, Ian E. Prise, Kelly Wemyss та ін. "Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis". Proceedings of the National Academy of Sciences 115, № 42 (2018): 10738–43. http://dx.doi.org/10.1073/pnas.1802320115.

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γδ T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how these cells contribute to homeostasis at the gingiva, a key oral barrier and site of the common chronic inflammatory disease periodontitis, has not been explored. Here we demonstrate that the gingiva is policed by γδ T cells with a T cell receptor (TCR) repertoire that diversifies during development. Gingival γδ T cells accumulated rapidly after birth in response to barrier damage, and strikingly, their absence resulted in enhanced path

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Escobedo Escobedo, Abner. "La importancia de la homeostasis en la salud oral y sistémica." Revista de la Asociación Dental Mexicana 78, no. 1 (2021): 48–50. http://dx.doi.org/10.35366/98387.

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Shan, M., M. Gentile, J. R. Yeiser, et al. "Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals." Science 342, no. 6157 (2013): 447–53. http://dx.doi.org/10.1126/science.1237910.

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Le Moual, Hervé. "Microbiota-derived metabolites modulate tissue homeostasis: relevance to the oral cavity?" Oral Diseases 22, no. 5 (2016): 350–52. http://dx.doi.org/10.1111/odi.12477.

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Chen, Zhangjian, Yun Wang, Xiang Wang, et al. "Effect of titanium dioxide nanoparticles on glucose homeostasis after oral administration." Journal of Applied Toxicology 38, no. 6 (2018): 810–23. http://dx.doi.org/10.1002/jat.3589.

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Dorban, Gauthier, Valérie Defaweux, Etienne Levavasseur, et al. "Oral scrapie infection modifies the homeostasis of Peyer’s patches’ dendritic cells." Histochemistry and Cell Biology 128, no. 3 (2007): 243–51. http://dx.doi.org/10.1007/s00418-007-0303-9.

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Shan, M., M. Gentile, JR Yeiser, et al. "Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals." Science 342, no. (6157) (2013): 447–53. https://doi.org/10.5281/zenodo.12933.

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Abstract:

A dense mucus layer in the large intestine prevents inflammation by shielding the underlying epithelium from luminal bacteria and food antigens. This mucus barrier is organized around the hyperglycosylated mucin MUC2. Here we show that the small intestine has a porous mucus layer, which permitted the uptake of MUC2 by antigen-sampling dendritic cells (DCs). Glycans associated with MUC2 imprinted DCs with anti-inflammatory properties by assembling a galectin-3-Dectin-1-FcγRIIB receptor complex that activated β-catenin. This transcription factor interfered with DC expression of inflam

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Şenel, Sevda. "An Overview of Physical, Microbiological and Immune Barriers of Oral Mucosa." International Journal of Molecular Sciences 22, no. 15 (2021): 7821. http://dx.doi.org/10.3390/ijms22157821.

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Abstract:

The oral mucosa, which is the lining tissue of the oral cavity, is a gateway to the body and it offers first-line protection against potential pathogens, exogenous chemicals, airborne allergens, etc. by means of its physical and microbiological-immune barrier functions. For this reason, oral mucosa is considered as a mirror to the health of the individual as well as a guard or early warning system. It is organized in two main components: a physical barrier, which consists of stratified epithelial cells and cell–cell junctions, and a microbiological-immune barrier that keeps the internal enviro

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Kaskova, L. F., та V. А. Honcharenko. "EFFECT OF THE THERAPEUTIC-PREVENTIVE COMPLEX ON РН AND ORAL FLUID MINERALIZING POTENTIAL IN CHILDREN EXAMINED WITH CHRONIC CATARRHAL GINGIVITIS AND DIABETES MELLITUS". Ukrainian Dental Almanac, № 2 (27 червня 2022): 41–45. http://dx.doi.org/10.31718/2409-0255.2.2022.07.

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Abstract. Objective of the research was to study рН and oral fluid mineralizing potential of the children examined with chronic catarrhal gingivitis and diabetes mellitus after administration of our therapeuticpreventive complex suggested including oral complex preparation “Quertulin”, drops “IMUPRET”, polyvitamins “Pikovit” and local irrigation of the oral cavity with the solution of the mouthwash “Exodent”. Administration of our therapeutic-preventive complex produced a positive effect on the oral cavity homeostasis and made it possible to improve the indices examined and maintain them on an

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