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Journal articles on the topic 'Oral Lichen planus (OLP)'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kadri, Sahar, Afef Slim, Adel Bouguezzi, Chaima Khalifa, Sameh Sioud, and Habib Hamdi. "Pediatric oral lichen planus." Journal of Oral Medicine and Oral Surgery 31, no. 1 (2025): 8. https://doi.org/10.1051/mbcb/2025011.

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Background: Oral lichen planus (OLP) is a rare chronic inflammatory mucocutaneous disorder in children, with limited research on its prevalence and clinical features. Therefore, more comprehensive studies are needed. The aim of this review was to synthesize the available evidence on pediatric OLP, its, clinical manifestations, etiology, and treatment options. Methods: The search of articles was conducted on Medline between January 2001 and December 2023. The search strategy was based on relevant keywords and Medical-Subject-Headings terms related to OLP and children. After selecting articles,

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2

Gregory, Majella, Sumaiya Irhouma, E. Anne Field, and Paul Yesudian. "Oral lichen planus: an update." Dental Update 52, no. 4 (2025): 244–49. https://doi.org/10.12968/denu.2025.52.4.244.

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Oral lichen planus (OLP) has an estimated global prevalence of 1% and is considered to be a disorder that requires lifelong surveillance. Clinical subtypes of OLP include reticular, atrophic, papular, plaque-like, ulcerative and bullous variants. OLP can present with desquamative gingivitis, and women may have associated vulval and/or vaginal involvement. Diagnosis of OLP is based on clinical and histopathological findings. Reticular and plaque-like OLP tends to be asymptomatic and seldom requires treatment. Ulcerative and atrophic OLP can generally be managed with topical corticosteroids. Sev

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3

Gadda, Rohit B., Rohini Salvi, and Varun Gul Bhatia. "Oral Lichen Planus : A Review." Journal of Contemporary Dentistry 1, no. 2 (2011): 33–36. http://dx.doi.org/10.5005/jcd-1-2-33.

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Abstract Oral lichen planus (OLP) is a chronic mucosal condition commonly encountered in clinical dental practice. Lichen planus is believed to represent an abnormal immune response in which epithelial cells are recognized as foreign, secondary to changes in the antigenicity of the cell surface. It has various oral manifestations, the reticular form being the most common. The erosive and atrophic forms of OLP are less common, yet are most likely to cause symptoms. Topical corticosteroids constitute the mainstay of treatment for symptomatic lesions of OLP. Recalcitrant lesions can be treated wi

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Agha-Hosseini, Farzaneh, Nafiseh Sheykhbahaei, and Maryam-Sadat SadrZadeh-Afshar. "Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review." Journal of Contemporary Dental Practice 17, no. 8 (2016): 692–701. http://dx.doi.org/10.5005/jp-journals-10024-1914.

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ABSTRACT Aim Many studies have suggested that a lesion originally diagnosed as oral lichen planus (OLP) has different possibilities of undergoing malignant transformation in time, although these findings remain a controversial issue; for example, some studies reported different values of potential malignancy of OLP. Introduction World Health Organization (WHO) classifies OLP as a “potentially malignant disorder” with unspecified malignant transformation risk, and suggests that OLP patients should be closely monitored. Numerous studies have attempted to confirm the malignant transformation pote

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Dermawan, I. G. N. Putra, and I. Nyoman Gede Juwita Putra. "MANAGEMENT OF ORAL LICHEN PLANUS TRIGGERED BY STRESS." Interdental Jurnal Kedokteran Gigi (IJKG) 17, no. 1 (2021): 27–33. http://dx.doi.org/10.46862/interdental.v17i1.1949.

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Introduction: Oral lichen planus (OLP) is a mucocutaneous disorder that rarely occurs around us and only involves the layer of the stratified squamous epithelium. Oral lichen planus is more common in women aged 30-65 years. The etiology of this disorder is not yet known, but there are several predisposing factors that play a role, such as hepatitis C virus infection, food, drugs, malignancy, and psychological factors. Purpose: This case report aims to describe the treatment of stress-induced OLP. Case Report: A 46-year-old man presented with complaints of stinging on the inner right and left c

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Naritasari, Fimma, Ayu Fresno Argadianti, and Nida Arum Fadilah. "Management of erosive oral lichen planus." MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM 10, no. 2 (2024): 61. https://doi.org/10.22146/mkgk.101017.

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Oral lichen planus (OLP) is an autoimmune disease that commonly affects the mucocutaneous area. The etiology of OLP remains unclear, but several factors are considered risk factors, such as chronic liver disease (hepatitis C infection), stress, genetics, hypertension, diabetes, smoking, and tobacco chewing. OLP often causes pain, especially during exacerbation periods. OLP management aims to reduce symptoms, improve clinical conditions, reduce the riskof oral cancer, and maintain oral health. This case report presents a case of OLP in a 54-year-old Javanese female patient with complaints of pa

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Albu, Cristina-Crenguta, Maria-Angelica Bencze, Anca-Oana Dragomirescu, et al. "Oral Lichen Planus Genetics Update." European Journal of Dental and Oral Health 3, no. 4 (2022): 1–5. http://dx.doi.org/10.24018/ejdent.2022.3.4.205.

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Lichen planus is a chronic autoimmune multi-factorial inflammatory condition of the mucocutaneous skin that mainly interests the skin and oral mucosa. Oral Lichen Planus (OLP) affects 0.5 to 1% of the world's population and all human races equally. The factors that act as triggers of autoimmune processes and determine the appearance of OLP are represented by genetic predisposition, skin injuries, viral infections, contact allergies, and medications. OLP affects the oral mucosa and occurs frequently on the inside of the cheeks and less often on the edges of the tongue, gums, or lips. The condit

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8

Sugerman, P. B., N. W. Savage, L. J. Walsh, et al. "The Pathogenesis of Oral Lichen Planus." Critical Reviews in Oral Biology & Medicine 13, no. 4 (2002): 350–65. http://dx.doi.org/10.1177/154411130201300405.

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Both antigen-specific and non-specific mechanisms may be involved in the pathogenesis of oral lichen planus (OLP). Antigen-specific mechanisms in OLP include antigen presentation by basal keratinocytes and antigen-specific keratinocyte killing by CD8+ cytotoxic T-cells. Non-specific mechanisms include mast cell degranulation and matrix metalloproteinase (MMP) activation in OLP lesions. These mechanisms may combine to cause T-cell accumulation in the superficial lamina propria, basement membrane disruption, intra-epithelial T-cell migration, and keratinocyte apoptosis in OLP. OLP chronicity may

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9

Hartanto, Firstine Kelsi, and Thomas George Kallarakal. "Pigmented Oral Lichen Planus: A Case Report." Scientific Dental Journal 1, no. 1 (2017): 11. http://dx.doi.org/10.26912/sdj.v1i1.1923.

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<p><strong>Background:</strong> Lichen planus is a chronic muccocutaneous inflammatory disorder. Oral lichen planus (OLP) has certain specific characteristics in its clinical presentation, but can also be presented in forms resembling other diseases. This may introduce difficulty in the diagnostic process. It has been reported that OLP affects between 0.1 to 4% individuals, predominantly women and people over 40 years old. <strong>Case Report:</strong> A 46-year-old woman complained of a non-healing ulcer present for 1.5 months. Intraorally, multiple white striae

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Liu, Haohao, Huiwen Chen, Yue Liao, et al. "Comparative Analyses of the Subgingival Microbiome in Chronic Periodontitis Patients with and without Gingival Erosive Oral Lichen Planus Based on 16S rRNA Gene Sequencing." BioMed Research International 2021 (June 27, 2021): 1–8. http://dx.doi.org/10.1155/2021/9995225.

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The aim of the study was to compare the microbiota composition and bacterial diversity of subgingival plaque in chronic periodontitis patients with and without gingival erosive oral lichen planus. The subgingival plaque samples of 20 chronic periodontitis patients with gingival erosive oral lichen planus (CP-OLP group) and 19 chronic periodontitis patients without gingival erosive oral lichen planus (CP group) were analyzed by 16S rRNA gene high-throughput sequencing. Compared with the CP group, the richness and diversity of subgingival plaque microflora in the CP-OLP group decreased significa

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Ramalingam, Suganya, Narasimhan Malathi, Harikrishnan Thamizhchelvan, Narasimhan Sangeetha, and Sharada T. Rajan. "Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions." Autoimmune Diseases 2018 (2018): 1–5. http://dx.doi.org/10.1155/2018/7936564.

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Introduction. Oral lichen planus (OLP) is a chronic T cell mediated disease of oral mucosa, skin, and its appendages with a prevalence of 0.5 to 2.6% worldwide. Oral lichenoid reactions (OLR) are a group of lesions with diverse aetiologies but have clinical and histological features similar to OLP, thereby posing a great challenge in differentiating both lesions. Mast cells are multifunctional immune cells that play a major role in the pathogenesis of lichen planus by release of certain chemical mediators. Increased mast cell densities with significant percentage of degranulation have been obs

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Yarom, N., T. Shani, N. Amariglio, et al. "Chromosomal Numerical Aberrations in Oral Lichen Planus." Journal of Dental Research 88, no. 5 (2009): 427–32. http://dx.doi.org/10.1177/0022034509337089.

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The malignant potential of oral lichen planus (OLP) has been a matter of serious controversy. We aimed to detect chromosomal numerical aberrations in cells of brush samples collected from affected mucosa. The samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) with chromosomes 2 and 8 centromeric probes. We analyzed 57 persons with OLP and 33 control individuals. A cut-off value of aneuploid cells was determined as 1.1%. Aneuploid cells were found in 16 persons with OLP (28.1%); in 10 individuals (17.5%), over 5% of the cells were aneuploid. Aneuplo

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Ion, Daniela I., and Jane F. Setterfield. "Oral Lichen Planus." Primary Dental Journal 5, no. 1 (2016): 40–44. http://dx.doi.org/10.1177/205016841600500104.

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Lichen planus (LP) is a relatively common autoimmune T-cell-mediated disease of unknown aetiology affecting the mucous membranes, skin and nails. Its prevalence varies between 0.5 and 2.2% of the population in epidemiological studies with a peak incidence in the 30–60 years range and with a female predominance of 2:1.1 Mucosal lichen planus tends to follow a chronic course with acute exacerbations. Spontaneous remission of oral lichen planus (OLP) is uncommon, and indeed mucosal LP may become worse with time. In contrast, cutaneous lichen planus may follow a milder clinical course though some

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Devi, Mutum Sangeeta, Khumukcham Sophia, and CH Anupriya. "Oral lichen planus: An overview." IP International Journal of Maxillofacial Imaging 9, no. 4 (2024): 176–78. http://dx.doi.org/10.18231/j.ijmi.2023.030.

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Oral lichen planus (OLP) is an immune-related disorder with an exact etiology unknown. It is a chronic inflammatory disease characterized by relapses and remission. Regular follow-up and keeping under observation are required as this lesion poses a chance for malignant transformation. In this article, we will discuss the various treatment modalities available for Oral Lichen Planus.

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Sugerman, P. B., P. A. Rollason, N. W. Savage, and G. J. Seymour. "Suppressor Cell Function in Oral Lichen Planus." Journal of Dental Research 71, no. 12 (1992): 1916–19. http://dx.doi.org/10.1177/00220345920710121201.

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Oral lichen planus (OLP) is a common inflammatory condition of the oral mucous membranes which affects between one and two percent of the general population. In accordance with the protracted clinical course of OLP and its association with known auto-immune diseases, the level of self-tolerance is questionable and possibly diminished in patients with this disorder. Normal suppressor T lymphocyte function is reputedly an essential element in the maintenance of self-tolerance, and deficient cell-mediated suppressor activity is implicated in the pathogenesis of auto-immune diseases. For assessmen

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Hesse, Juliane, Andreas Schmalfuss, and Sigrid I. Kvaal. "Photodynamic therapy of oral lichen planus." Photochemical & Photobiological Sciences 19, no. 10 (2020): 1271–79. http://dx.doi.org/10.1039/d0pp00249f.

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Alsarraf, Abdulhameed, Kunj Mehta, and Nabil Khzam. "The Gingival Oral Lichen Planus: A Periodontal-Oral Medicine Approach." Case Reports in Dentistry 2019 (January 6, 2019): 1–3. http://dx.doi.org/10.1155/2019/4659134.

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We present a case of a 77-year-old female who suffered from oral lichen planus (OLP) involving her gingiva and bilateral buccal mucosa for over 6 months. We showed that oral hygiene measures and conventional periodontal treatment and strict maintenance were sufficient to control the gingival involvement of OLP. The mechanism of OLP is complex and not yet fully understood. The focus of discussion in our case was that knowledge and understanding of gingival pathology are fundamental for a determined management approach. Our case was managed according to the suggested protocols in previous case s

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Kartika Sari, Rina, Kus Harijanti, Adiastuti Endah P, and Hening Tuti H. "MANAGEMENT OF ULCERATIVE ORAL LICHEN PLANUS PREDISPOSED BY PSYCHOLOGICAL STRESS." Dentino : Jurnal Kedokteran Gigi 7, no. 2 (2022): 204. http://dx.doi.org/10.20527/dentino.v7i2.14632.

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Background: Oral lichen planus (OLP) is a chronic inflammatory autoimmune oral mucosa disease. The ulcerative type of OLP presents as erythematous ulceration with mucosal erosions surrounding whitish striae. The aetiology of OLP is unknown, but can be predisposed by psychological factors. Purpose: Reporting ulcerative oral lichen planus predisposed by psychological stress. Case: A 36 years old woman complained very painful ulcer in the right buccal mucosa and a grey-purple lower lip lesion for a year. It had been treated with topical corticosteroids, antibiotics, tretinoin, and vitamins but di

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Georgakopoulou, Eleni A., Marina D. Achtari, Michael Achtaris, Periklis G. Foukas, and Athanassios Kotsinas. "Oral Lichen Planus as a Preneoplastic Inflammatory Model." Journal of Biomedicine and Biotechnology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/759626.

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Oral lichen planus (OLP) is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC) in the long run. While World Health Organization (WHO) classifies OLP as “a potentially malignant disorder,” it is still a matter of debate which mechanisms drive OLP to such a condition. The current hypothesis connecting OLP and OSCC is that chronic inflammation results in crucial DNA damage which over time results in cancer development. Initial studies investigating the OLP and OSCC link were mainly retrospective clinical

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Vinod, V. C., and Roza Rajkumar Baviskar. "A Challenging Case of Oral Lichen Planus: A Comprehensive Review." Journal of Primary Care Dentistry and Oral Health 4, no. 3 (2023): 112–15. http://dx.doi.org/10.4103/jpcdoh.jpcdoh_30_23.

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Abstract Oral lichen planus (OLP) is a chronic mucocutaneous disorder affecting the oral mucosa. This case report presents a comprehensive assessment of a 64-year-old male patient with OLP, detailing the clinical presentation, diagnosis, and management. The patient’s chief complaint was a persistent burning sensation in the oral cavity for several months. Furthermore, he expressed the need to replace missing teeth. The patient was treated with a combination of topical corticosteroids, multivitamins, and systemic steroids, which yielded significant improvement in symptoms. This case highlights

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Baby, Tibin K., P. R. Bindhu, Rekha Krishna Pillai, and P. Jayanthi. "Immunohistochemical expression of cyclooxygenase-2 in oral lichen planus and normal oral mucosa." Indian Journal of Pathology and Microbiology 65, no. 1 (2022): 8–12. http://dx.doi.org/10.4103/ijpm.ijpm_1304_20.

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Background: Oral lichen planus (OLP) is a chronic inflammatory disease for which the pathogenesis is complex and not fully understood; autoimmunity has been suggested as a causative factor. World health organization (WHO) has classified OLP as a potentially malignant lesion. Cyclooxygenase-2 (COX-2) is an inducible key enzyme that generates prostanoids which play a critical role in inflammation, immunopathology; also considered as a malignant potential marker. Aims: The present study was conducted to analyze and compare epithelial COX-2 expression in OLP clinical subtypes and normal oral mucos

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Tampa, Mircea, Constantin Caruntu, Madalina Mitran, et al. "Markers of Oral Lichen Planus Malignant Transformation." Disease Markers 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/1959506.

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Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients’ quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression.

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Sagarmani and Nisheeth Saawarn. "Integrative approach in managing oral lichen planus." Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology 10, no. 2 (2024): 84–87. http://dx.doi.org/10.18231/j.jooo.2024.015.

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Oral lichen planus (OLP) is a well-known chronic inflammatory disorder which is linked with alteration in functioning of cell-mediated immune function. It is characterised by repeated exacerbations, prolonged evolution, pain, resistant to treatment, thus affecting the quality of life of patients. The present review focuses on treatment strategies of OLP and how these methods improve the quality of life of patient. The main aim of OLP therapy is reducing the symptoms and eliminating the occurrence of mucosal related lesions, along with reduction of oral cancer risk. The common treatment modalit

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Stoleriu, Gabriela, Ancuta Lupu, Florina Filip Ciubotaru, Minela Maranduca, Cristina Stanescu, and Daciana Elena Branisteanu. "STUDY ON THE IMPACT OF ORAL EROSIONS ON THE QUALITY OF LIFE OF PATIENTS WITH LICHEN PLANUS." Romanian Journal of Oral Rehabilitation 16, no. 3 (2024): 303–11. https://doi.org/10.62610/rjor.2024.3.16.32.

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Lichen planus (LP) is a chronic inflammatory disease affecting the skin and mucous membranes, particularly the oral mucosa. Oral lichen planus (OLP) is characterized by erosive lesions that can significantly impact the quality of life (QoL) of patients. This study aims to assess the impact of oral erosions on the QoL of patients with OLP, exploring the clinical features, symptom severity, and psychological burden associated with the condition. The increased symptom and disease duration proportionally correlated with higher OHIP-49 questionnaire mean scores. According to the OHIP-49 questionnai

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Wafaa, Saleh, Youssef Jilan M, Ata Fatma, Anees Mohamed M, Cha Seunghee, and Katz Joseph. "Risk co-factors inducing malignant transformation of oral lichen planus: A literature review of clinical studies." Journal of Clinical Advances in Dentistry 5, no. 1 (2021): 005–11. http://dx.doi.org/10.29328/journal.jcad.1001024.

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Oral lichen planus (OLP) is an autoimmune chronic inflammatory disease. The potential risk of malignant transformation in OLP remains controversial. The aim of the present study was to review original clinical studies published in indexed databases, which assessed the potential risk cofactors which were implicated in the malignant transformation of oral lichen planus. We focused our search to include most of the studies that reported malignant transformation of oral lichen planus using different combinations of the following key indexing terms: oral lichen planus, malignant transformation, smo

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Jalal Hamza, Vaman, Ali Fakhree Alzubaidee, and Dindar Sharif Qurtas. "Clinical Study of Patients with Oral Lichenoid Processes Attending Khanzad Specialized Teaching Center and Erbil Dermatology Teaching Center." Diyala Journal of Medicine 19, no. 2 (2020): 96–106. http://dx.doi.org/10.26505/djm.19025460628.

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Background: Lichen planus is a common chronic inflammatory disease of the skin and mucous membranes. Oral Lichenoid Reactions (OLRs) comprise a group of lesions with different causative factors such as systemic medication, dental restorative materials, foods, or flavoring agents. Pathologists often group these conditions under the umbrella term of ‘lichenoid processes’. Objective: To provide prevalence and demographic distribution of Oral Lichen Planus (OLP) and OLR among a sample of patients. Patients and Methods: This cross-sectional study was conducted in the Khanzad Teaching Center and Erb

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Wang, Dan. "New Progress in the Combined Treatment of Traditional Chinese and Western Medicine for Oral Lichen Planus." International Journal of Public Health and Medical Research 1, no. 3 (2024): 111–14. http://dx.doi.org/10.62051/ijphmr.v1n3.16.

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Oral lichen planus (OLP) is a common chronic oral mucosal disease, with a complex etiology and difficult treatment. [1] This article reviews the new progress of integrated traditional Chinese and Western medicine treatment for oral lichen planus, including Western medicine treatment methods, traditional Chinese medicine treatment concepts, specific plans for integrated traditional Chinese and Western medicine treatment, as well as their advantages and mechanisms of action. It also looks forward to future research directions.

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Chaudhry, Sunil, G. Manmohan, K. Aishwarya Yadav, and G. Madhulika. "Lichen planus – A refractory autoimmune disorder." IP Indian Journal of Clinical and Experimental Dermatology 9, no. 1 (2023): 20–27. http://dx.doi.org/10.18231/j.ijced.2023.003.

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Lichen planus (LP) is a chronic inflammatory mucocutaneous disease of unknown aetiology with an estimated incidence of 0.5%–4.0% having a female preponderance at a ratio of 1.5:1. Oral lichen planus (OLP) is commoner than the cutaneous form and tends to be more persistent and more refractory to the treatment. The prevalence of oral lichen planus in Indian population is around 3% with more female predilection. Oral lesions occur in 50%–70% of the patients with lichen planus. LP is considered to be a T-cell-mediated autoimmune skin disease, in which CD8+ cytotoxic T lymphocytes are major mediato

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Dalirsani, Zohreh, Maryam Amirchaghmaghi, Ala Ghazi, Seyed Isaac Hashemy, and Mahboobeh Taherizadeh. "Assessment of salivary opiorphin in oral lichen planus." Brazilian Journal of Oral Sciences 22 (January 26, 2023): e237270. http://dx.doi.org/10.20396/bjos.v22i00.8667270.

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Opiorphin is a pentapeptide, which could be isolated from human fluids and has a decreasing effect on pain. Aim: Since lichen planus is a chronic mucocutaneous disease, which causes pain or burning feeling in the oral mucosa, this study aimed to compare salivary opiorphin levels of oral lichen planus (OLP) patients with healthy subjects. Methods: This case-control study, was performed on 24 patients with OLP lesions and 21 healthy subjects. After collecting unstimulated saliva, opiorphin levels were compared between two groups through statistical analyses. Results: There was not any significan

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Krishnapriya Umashankar and Hannah R. "Correlation Of Clinical Severity Of Oral Lichen Planus With Treatment Prognosis - A Retrospective Institution Based Study." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (2020): 1937–42. http://dx.doi.org/10.26452/ijrps.v11ispl3.3669.

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Lichen planus is a chronic mucocutaneous immunologically mediated disease which is triggered by varied etiological agents. Lichen planus shows many clinical features affecting the skin, oral cavity, genital organ, nail and scalp. Lichen planus has well documented clinical findings and histological findings that aid in diagnosis. This retrospective study was done to assess the clinical severity of Oral Lichen Planus (OLP) and compare it to the treatment prognosis of the patients visiting our institution. A total of 60 clinically diagnosed OLP patients were included. Clinical and treatment detai

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Zhong, Evelyn F., Andrea Chang, Andres Stucky, et al. "Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens." Pathogens 9, no. 11 (2020): 952. http://dx.doi.org/10.3390/pathogens9110952.

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Oral lichen planus (OLP) is a common chronic inflammatory disease affecting the oral mucosa. The pathogenesis of OLP is incompletely understood but is thought to be related to the immune system. As the oral cavity is a major reservoir and transmission gateway for bacteria, viruses, and fungi, the microbial composition of the oral cavity could play a role in the pathogenesis of OLP. However, limited by analytic technology and knowledge of the microbial community in the oral cavity, it is not yet clear which pathogens are associated with OLP. Next generation sequencing (NGS) is a powerful tool t

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Shrivastava, Harshit, Mahesh Shenoy, Nishath Sayed Abdul, et al. "Immuno-histochemical evaluation of CD34 for OLP and OSMF." Bioinformation 20, no. 4 (2024): 358–61. http://dx.doi.org/10.6026/973206300200358.

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Immuno-histochemical evaluation of CD34 in oral lichen planus (OLP) and Oral Submucous Fibrosis (OSMF) is of interest to dentist.20 specimens of normal oral mucosa (buccal mucosa/gingiva tissue) from patients who had extractions performed as part of orthodontic treatment comprised Group I, the control group. Group II comprised 30 individuals with a diagnosis of oral lichen planus. 30 OSMF cases with diagnoses is Group III. These 80 specimens were all given consideration when choosing for CD34immuno-histochemical staining. The CD34 was greater in all categories of OLP and OSMF when compared to

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Акмалова, Г., G. Akmalova, С. Чуйкин, et al. "The use of genetic markers in predicting of oral lichen planus development and recurrence." Actual problems in dentistry 12, no. 1 (2016): 62–69. http://dx.doi.org/10.18481/2077-7566-2016-12-1-62-69.

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To reveal the association of the interleukin 8 (IL-8) gene with the development and progression of oral lichen planus (OLP) we performed RT-PCR analysis of rs4073 polymorphism in the IL-8 gene in 92 oral lichen planus patients and 163 healthy individuals of Russian ethnic origin from the Volga-Ural region of Russia. The investigation showed the importance of polymorphism rs4073 of IL-8 gene for oral lichen planus development. The disease was associated with genotype rs4073*T / T which was found to be the genetic marker of high risk for oral lichen planus development, and rs4073*A / T genotype

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Jung, Won, and Sungil Jang. "Oral Microbiome Research on Oral Lichen Planus: Current Findings and Perspectives." Biology 11, no. 5 (2022): 723. http://dx.doi.org/10.3390/biology11050723.

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Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa with an unknown etiology. The role of oral microbes in the development of OLP has gained researchers’ interest. In this review, we summarized the findings of studies focused on the relationship between OLP and oral microbiome, which includes the composition of oral microbiota, molecules produced by oral microbiota or the host, and the oral environment of the host. According to the studies, the oral microbial community in OLP patients undergoes dysbiosis, and the microbial dysbiosis in OLP patients is more prominent i

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Ravnitya, Singh1, and Singh2 Supreet. "Association of Lichen Planus With Hepatitis C Virus." A Journal of Clinical Dentistry HealTalk 15, no. 03 (2023): 29–31. https://doi.org/10.6681/zenodo.72068427.

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The relationship between chronic hepatitis C virus infection (HCV) and oral lichen planus (OLP) is a current topic in the field of oral medicine. Many studies of this association have been made over time. The geographic variation of the hepatitis C prevalence proved to be an important factor influencing the statistical results of the studies analyzing the association of the oral plan lichen with the hepatitis C virus. Approaching this issue is not to be neglected. Treatment outcomes in patients with oral lichen planus associated with chronic hepatitis C virus are often unsatisfactory compared

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Ravnitya, Singh, and Singh Supreet. "Association of Lichen Planus With Hepatitis C Virus." A Journal of Clinical Dentistry HealTalk 14, no. 06 (2022): 20–21. https://doi.org/10.4880/zenodo.7839752.

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Abstract     The relationship between chronic hepatitis C virus infection (HCV) and oral lichen planus (OLP) is a current topic in the field of oral medicine. Many studies of this association have been made over time. The geographic variation of the hepatitis C prevalence proved to be an important factor influencing the statistical results of the studies analyzing the association of the oral lichen planus with the hepatitis C virus. Approaching this issue is not to be neglected. Treatment outcomes in patients with oral lichen planus associated with chronic hepatitis C virus are

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Kirandeep Kaur, Mridha Sharma, and Gurkiran Kaur. "An Unusual Case Report of Erythematous Lichen Planus in a 23 Year Old Female." International Healthcare Research Journal 2, no. 2 (2018): 38–40. http://dx.doi.org/10.26440/ihrj/02_02/166.

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Oral Lichen planus (OLP) or lichen ruber planus is was first described by Wilson in 1869 and affects about 0.5-1% of the population and 2.6% of the Indian population. It is more frequently present in the female population with age usually above 50 years which is inconsistent with the present case. The rate of malignant transformation of OLP is quite low, although erythematous OLP has a higher incidence. The diagnosis of OLP is done on the basis of clinical examination (oral and skin lesions), biopsy and direct immunofluorescence and its management is aimed mainly at palliation of the symptoms.

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Zuo, Yu-Ling, Di-Ping Gong, Bi-Ze Li, et al. "The TF-miRNA Coregulation Network in Oral Lichen Planus." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/731264.

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Oral lichen planus (OLP) is a chronic inflammatory disease that affects oral mucosa, some of which may finally develop into oral squamous cell carcinoma. Therefore, pinpointing the molecular mechanisms underlying the pathogenesis of OLP is important to develop efficient treatments for OLP. Recently, the accumulation of the large amount of omics data, especially transcriptome data, provides opportunities to investigate OLPs from a systematic perspective. In this paper, assuming that the OLP associated genes have functional relationships, we present a new approach to identify OLP related gene mo

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Kökten, Numan, Lokman Uzun, Ayşe Serap Karadağ, Tülay Zenginkinet, and M. Tayyar Kalcıoğlu. "Grinspan’s Syndrome: A Rare Case with Malignant Transformation." Case Reports in Otolaryngology 2018 (2018): 1–4. http://dx.doi.org/10.1155/2018/9427650.

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Aim. Oral lichen planus (OLP) is one of the common chronic inflammatory, noninfectious, and precancerous oral mucosal diseases that affect the stratified squamous epithelium in adults. Grinspan et al. reported an association of OLP with diabetes mellitus and vascular hypertension and called that Grinspan’s syndrome in 1966. We aim to present a case of Grinspan’s syndrome with malignant transformation. Case Presentation. A 60-year-old man who presented with a ten-year history of OLP diagnosed clinically and histologically was referred to our otolaryngology department with a painless swallowing

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Donovan, Jeffrey C. H., Robert C. Hayes, Karen Burgess, Iona T. Leong, and Cheryl F. Rosen. "Refractory Erosive Oral Lichen Planus Associated with Hepatitis C: Response to Topical Tacrolimus Ointment." Journal of Cutaneous Medicine and Surgery 9, no. 2 (2005): 43–46. http://dx.doi.org/10.1177/120347540500900201.

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Background: Erosive lichen planus is a painful and disabling disease that is frequently resistant to topical and systemic therapies. Current therapies are considered palliative rather than curative as many patients relapse after discontinuing treatment. An association has been reported between some cases of oral lichen planus (OLP) and chronic hepatitis C infection. Objective: We report on a 51-year-old hepatitis C-positive man with corticosteroid refractory erosive lichen planus of the lip who had a rapid resolution of his lesions following a two-week course of topical 0.1% tacrolimus ointmen

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Swain, Niharika, Shilpa Patel, Jigna Pathak, Priyadarshani R. Sarkate, Rashmi H. Hosalkar, and Nikita K. Sahu. "Role of Candida Species in Oral Lichen Planus." Journal of Contemporary Dentistry 9, no. 3 (2019): 124–29. http://dx.doi.org/10.5005/jp-journals-10031-1270.

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ABSTRACT Candida albicans is the most common fungal pathogen in humans, although other Candida species can also cause candidiasis. Patients with symptomatic or erythematous oral lichen planus (OLP) have commonly been associated with these. In recent times, however, there has been a notable shift in the incidence of non-Candida albicans (NCA) species which is gaining prominence due to significant differences in their susceptibility to antimycotic drugs. Studies showed that C. glabrata and C. tropicalis were the most common NCA species isolated in OLP. Treatment failure is common among NCA speci

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Radwan-Oczko, Małgorzata, Anna Rybińska, Agata Mierzwicka, and Irena Duś-Ilnicka. "Salivary Histamine Levels in Patients with Oral Lichen Planus Lesions." Medicina 60, no. 7 (2024): 1038. http://dx.doi.org/10.3390/medicina60071038.

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Background and Objectives: An oral lichen planus (OLP) chronic lesion refers to a group of oral potentially malignant disorders (OPMDs) that still lack a proper understanding from the point of view of relevant biomarkers for diagnostics and prognosis. The aim of the study was to assess the salivary histamine levels in patients with oral lichen planus lesions. Materials and Methods: The study included a group of 76 patients with oral lichen planus. General diseases and medication taken, smoking habits, severity of pain assessed using a visual analogue scale (VAS), oral hygiene status, and durat

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Swarnaa, Chaturvedi, Singh Priya, Umapathy Deepak, and Rai Puja. "Evaluation of Correlation of Symptoms of Anxiety, Depression, and Xerostomia in Oral Lichen Planus (OLP) Patients Using Questionnaires." Cross Current International Journal of Medical and Biosciences 5, no. 02 (2023): 33–39. http://dx.doi.org/10.36344/ccijmb.2023.v05i02.002.

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Background and Aim: Oral Lichen Planus is a relatively common mucocutaneous disorder with autoimmune etiology. Considering its malignant potential, diagnosing and treating this disorder from all dimensions is crucial. One such multi-dimensional aspect of OLP was aimed to be put forth through our study of the correlation of anxiety, depression, and xerostomia using questionnaires. Materials and Methods: A group of 15 Oral Lichen Planus patients included in this study from outpatients in a college in Uttar Pradesh. The symptoms of Anxiety-Depression disorder and salivary gland disorders in oral

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Nouraddini, Nazanin, and Giorgi Dugashvili. "Oral Microbiome and Its Role in Oral Lichen Planus Development: A Literature Review." European Scientific Journal, ESJ 21, no. 39 (2025): 30. https://doi.org/10.19044/esj.2025.v21n39p30.

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This article aims to explore the oral microbiome, the implications of its dysbiosis and its role in the development of oral lichen planus (OLP) and systemic diseases. This underscores the necessity for additional research to elucidate the connections between oral microorganisms and the pathology of OLP. Furthermore, a deeper understanding of these intricate interactions may pave the way for novel therapeutic strategies and improved disease management. An electronic search was conducted using PubMed and Scopus, complemented by a manual review of the reference lists of the identified articles fo

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Netto, Juliana de Noronha Santos, Fábio Ramoa Pires, Karen Hurtado Andrade Costa, and Ricardo Guimarães Fischer. "Clinical features of oral lichen planus and oral lichenoid lesions: an oral pathologist’s perspective." Brazilian Dental Journal 33, no. 3 (2022): 67–73. http://dx.doi.org/10.1590/0103-6440202204426.

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Abstract The clinicopathological features that precisely characterize oral lichen planus (OLP) and oral lichenoid lesions (OLL) still represent a challenge. The aim of the present study was to analyze, from an oral pathologist perspective, the clinical features from OLP and OLL. Specimens fullfilling the histological criteria for OLP and OLL, and also compatible with OLP (OLP-C), were selected and clinical information was retrieved from the laboratory forms. The final sample was composed by 221 cases, including 119 OLP (53.8%), 65 OLP-C (29.4%) and 37 OLL (16.7%). Females were more affected in

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Bikmurzin, Vladimir, Ludmila Balyabina, Irina Gimraniva, et al. "FEATURES OF IMMUNOLOGICAL REACTIVITY OF PATIENTS WITH LICHEN PLANUS OF THE ORAL MUCOSA." Actual problems in dentistry 17, no. 3 (2021): 24–28. http://dx.doi.org/10.18481/2077-7566-21-17-3-24-28.

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Lichen planus is considered as a multifactorial disease. Various factors play a role in the development of lichen planus of the oral mucosa: genetic, dental materials that are used for restoration, prosthetics of teeth, Helicobacter pylori, viruses, psychological stress, somatic pathology and others. The pathogenesis of oral lichen planus is based on an autoimmune process. The aim of the study was to determine the immunological reactivity in patients with various clinical forms of lichen planus of the oral mucosa. The study carried out clinical, laboratory examination of 75 female patien

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Sotoodian, Bahman, Jacky Lo, and Andrew Lin. "Efficacy of Topical Calcineurin Inhibitors in Oral Lichen Planus." Journal of Cutaneous Medicine and Surgery 19, no. 6 (2015): 539–45. http://dx.doi.org/10.1177/1203475415591936.

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Background: Oral lichen planus (OLP) is associated with severe pain and significant impairment for patients. Objective: To evaluate the safety and efficacy of topical calcineurin inhibitors (TCI) in the treatment of OLP. Methods: Medline and the Cochrane Database were searched using the keywords “calcineurin inhibitor OR tacrolimus OR pimecrolimus” AND “oral lichen planus.” Results: Four retrospective studies that looked at the effects of tacrolimus on OLP; 4 randomized, double-blind clinical trials (RDBCT) comparing tacrolimus with topical corticosteroids; and 5 RDBCT comparing pimecrolimus w

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Oberti, Luca, Lucchese Alberta, Petruzzi Massimo, Carinci Francesco, and Lauritano Dorina. "Clinical Management of Oral Lichen Planus: A Systematic Review." Mini-Reviews in Medicinal Chemistry 19, no. 13 (2019): 1049–59. http://dx.doi.org/10.2174/1389557519666190301144157.

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Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment. Materials & Methods: We searched and analyzed PubMed database for articles on OLP management. Only randomized controlled trials, comparing an active treatment with placebo, or between different active treatments, were considered in this systematic review. Only patients with symptomatic OLP were included and interventions of all types were considered (topical treatm

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Garg, Shubhangi, Sangeeta S. Malik, Nagaraju Kamarthi, Sumit Goel, and Swati Gupta. "Review: recent trends in management of oral lichen planus." International Journal of Basic & Clinical Pharmacology 12, no. 2 (2023): 317–23. http://dx.doi.org/10.18203/2319-2003.ijbcp20230407.

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Oral lichen planus (OLP) is a chronic mucocutaneous inflammatory disease, associated with altered cell‐mediated immunological function. It has been characterised by long‐term evolution, repeated exacerbations, sometimes painful and resistant to treatment, or even all of these. OLP significantly affects quality of patient's life. There is a higher risk of malignant transformation accompanied with OLP and similar appearing oral lichenoid lesions. Current OLP therapy aims at eliminating all mucosal‐related lesions reduce symptomatology and decrease the risk of oral cancer. This review summarizes

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Vikey, Ashok, and Astha Pusame. "Evaluation of Candidal Species in Oral Submucous Fibrosis and Oral Lichen Planus: A Microbiological Study." Microbiology Research Journal International 34, no. 5 (2024): 29–37. http://dx.doi.org/10.9734/mrji/2024/v34i51444.

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Background: Candida is opportunistic microorganisms in oral cavity, causes oral candidiasis. The presence of candida and subspecies in oral premalignant lesions may intensify the infection and transform pre malignant lesions into cancer. Objective: To isolate various types of candida species, among Oral submucous fibrosis (OSMF) and Oral lichen Planus (OLP) patients. Methodology: Total 60 individuals included and grouped as; OSMF (n=20) group A, Lichen Planus (n=10); group B and Controls (n=30) group C. Results: The higher candida carriage revealed in OSMF+ OLP groups (23.3%) as compared to co

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