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Dissertations / Theses on the topic 'Oral pathology and medicine'

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1

Pinho, Rodrigo Finger de Carvalho. "Estudo retrospectivo entre o fibroma ossificante, displasia fibrosa, displasia cemento-ossificante e lesões centrais de células gigantes." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/23/23154/tde-15082018-094840/.

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As lesões ósseas são doenças raras, mas com um grande destaque, que afetam a região maxilofacial. Dentre elas podemos destacar as Lesões Centrais de Células Gigantes e as Lesões Fibro-Ósseas Benignas (Displasia Cemento-Ossificante, Fibroma Ossificante e Displasia Fibrosa). O presente estudo teve como objetivo descrever e analisar os dados encontrados nas fichas de encaminhamento clínico presentes no Serviço de Patologia Oral e Maxilofacial da Faculdade de Odontologia da Universidade de São Paulo. Foram avaliados 89.265 casos em um período que variou de 1950 até 2016, utilizando as categorias d
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2

Ellington, Lori Fay. "The Relationship Between Decayed, Missing, and Filled Teeth (DMFT) and Microbial Screening in the Oral Cavity." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etd/1412.

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The objective was to determine if a correlation exists between Streptococcus mutans and DMFT in the oral cavity. This study examined the feasibility of microbial screenings as an additional caries predictor tool. The sample included 108 participants (ages 18-25) in low, moderate, and high socioeconomic groups. Subjects were selected from one dental clinic and one college in Virginia. Subjects were assessed for DMFT, salivary and plaque bacterial load, and CRA. Salivary load positively correlated with the DMFT. Plaque bacterial load and CRA negatively correlated with DMFT. Comparison of salivar
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3

Wadelius, Philip, and Lars Salomonsson. "Early Detection of Malignancies and Potential Malignancies in the Oral Cavity - a systematic review." Thesis, Umeå universitet, Institutionen för odontologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143907.

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Oral cancer is a major health problem, with over 500000 patients diagnosed each year. Although progress has been made in regards to both diagnosis and treatment, the overall 5-year survival rate has not changed much in the last 30 years and still relatively static at around 50 %. This high mortality rate is related to late diagnosis of oral malignancies. At stages III and IV the 5-year survival rate is as low as 30 %, however if diagnosed at stage I the survival rate increases substantially to approximately 80 %. Research in to viable methods for early detection of oral malignancies and potent
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4

Haynes, Angela. "Assessing Nurse Practitioners' Knowledge and Clinical Practice with Regard to the Oral-Systemic Link." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3848.

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Nurse Practitioners (NPs) comprise a significant portion of the U.S. primary care workforce and play an essential role in patients' health awareness, prevention strategies, disease management, and in providing appropriate provider referrals. Nurse Practitioners receive education on the oral-systemic connection, yet there have been limited studies on the clinical practice of NPs assessing the oral cavity to evaluate the condition of the teeth and the oral tissues. The purpose of this study was to explore the nurse practitioners’ knowledge and practice habits of assessing the oral cavity for dis
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5

Banerjee, Anirban. "Development of an automated electrogustometer." Thesis, University of Sussex, 2011. http://sro.sussex.ac.uk/id/eprint/6957/.

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In spite of electrogustometry having been in existence since the 1930s, there is no state of the art instrument to assess the electrogustometric threshold. A state of the art electrogustometer has been designed and constructed and tested for reliability and repeatability. This is based on embedded digital technology and is a semi-automatic, battery-powered portable instrument. Physical factors such as electrode area and stimulus duration affect the taste threshold but there are no recommended standards for these factors. Studies have been conducted to ascertain a recommended standard – a circu
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6

Sangare, Abou Dramane. "Comportements en santé orale et déterminants du recours aux soins dans le département de Dabou - Côte d'Ivoire." Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00845002.

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En Côte d'Ivoire, la problématique de l'accessibilité aux soins reste entière en raison de l'insuffisance des infrastructures sanitaires et du manque de ressources financières. Aussi, la population a t-elle souvent recours à l'odontologie traditionnelle pour répondre à ses besoins prioritaires de santé. Cependant, l'absence de données factuelles dans un contexte de pluralité de soins constitue un handicap pour la définition d'une politique de santé bucco-dentaire efficiente. L'objectif de la présente étude a été de décrire l'activité des tradipraticiens, puis de déterminer les facteurs influen
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7

Belfield, Louise Alicia. "Interactions between porphyromonas gingivalis and macrophages in oral pathology." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1611.

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Macrophages play a fundamental role in driving both inflammatory and immunosuppressive conditions of the oral mucosa. Periodontitis, a chronic inflammatory condition affecting the supporting structures of the teeth, is widely prevalent, affecting a large proportion of the global population, and has been linked to the development of systemic inflammatory diseases. Oral squamous cell carcinoma (OSCC) is placed sixth in the WHO rankings of cancer incidence worldwide, and despite continuing research into underlying mechanisms, incidence is on the rise. Aberrant macrophage function has been implica
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8

Riffel, Amy Marie. "Osteoblasts aggregates cultivated in a 3-dimensional culture environment rigorously respond to Porphyromonas gingivalis culture supernatants." Thesis, University of Iowa, 2011. https://ir.uiowa.edu/etd/1067.

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An exciting alternative to the current methods for bone regeneration is osseous tissue engineering. One such method focuses on enhancement of osteoblast differentiation through rotary cell culture techniques. The response of osteoblast aggregates to periodontal microorganisms and their by-products will ultimately be important in their success as a method of bone regeneration. In this study, I hypothesize that human embryonic palatal mesenchymal (HEPM, ATCC 1486) pre-osteoblast cells produce different cytokine responses depending upon whether they are grown in a 2-dimensional tissue culture fla
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9

Chu, Rene. "Age and Sex-Related Differences in Dental Pulp Stem Cells." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/4830.

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Objective: An in vitro study to determine the age and gender related changes of dental pulp stem cells in regards to proliferative capacity and lineage dependent effects on differentiation capabilities. Material and Methods: Specimens have been collected from a population ranging from 16 yrs of age to 78 yrs of age. Intact, non-carious teeth were collected from the oral surgery department at College of Dentistry at the University of Iowa. A total of 20 specimens were collected. Teeth were collected, sectioned and pulpal tissue collect
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10

Tengan, Kelsey S. "Prospective, comparative assessment of alveolar ridge preservation using Guidor® Easy-Graft® Classic in atrumatic extraction socket." Thesis, University of Iowa, 2017. https://ir.uiowa.edu/etd/5861.

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Objectives: Tooth extraction initiates a cascade of biological events leading to the reduction of alveolar ridge volume. Alveolar ridge preservation (ARP) is a surgical treatment which aims at minimizing hard and soft tissue changes following tooth extraction. Several techniques and materials have been studied and used clinically in ARP. The selection of the biomaterials used for this technique is determined by several factors, such as features of the extraction site, inherent biomaterial properties and handling preferences by the surgeon, among others. The purpose of this study was to evaluat
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11

Poulsen, Christopher. "Differential cytotoxicity of long-chain bases for human oral keratinocytes, fibroblasts, dendritic and oral squamous cell carcinoma cell lines." Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/4723.

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Long-chain bases (sphingosine, dihydrosphingosine, and phytosphingosine) are present in the oral cavity and have potent antimicrobial activity against oral pathogens. However, little is known about their cytotoxicity for oral cells, an important step in considering their potential as future antimicrobial agents for oral infections. In this study, primary oral keratinocytes, primary oral fibroblasts, dendritic cells, and oral squamous cell carcinoma cells were exposed to 10.0-640.0 µM long-chain bases and glycerol monolaurate (GML) in cell culture medium containing resazurin (e.g., Alamar Blue,
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12

Rinehart, Sarah. "Periodontal phenotype and supracrestal soft tissue dimensions – clinical correlations and their impact on post-extraction volumetric changes." Thesis, University of Iowa, 2017. https://ir.uiowa.edu/etd/5834.

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Objectives: Extraction of a tooth leads to a series of healing events that are intimately associated with dimensional changes in the alveolar ridge that typically result in a net volume loss. Previous studies have evaluated the extent and pattern of those resorptive changes, however it remains challenging to predict the degree of change that will occur, as numerous local and systemic factors may play a role in the biologic events that follow tooth extraction. The purpose of this study was to assess the role that phenotypic characteristics of the periodontium play in the alveolar ridge remodeli
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13

García, Loera José Miguel. "Patient satisfaction and oral health-related quality of life outcomes in edentulous patients being treated with complete dentures by dental students at the University of Iowa College of Dentistry and Dental Clinics." Thesis, University of Iowa, 2018. https://ir.uiowa.edu/etd/6421.

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Objectives: The aim of this study is to investigate the impact of multiple factors in the Oral Health Related Quality of Life of patients being treated with Conventional Complete Dentures, including: a) Level of expertise of the dental provider (third year dental student vs. fourth year dental student); b) Length of time edentulous; c) Number of previous prostheses; d) Race; e) Sex; f) Age; g) Systemic conditions; h) Condition of the bone ridge; i) Economic factor and insurance coverage, in patients at the University of Iowa College of Dentistry (D3 and D4 Clinics). Materials and methods: Eigh
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14

Handoo, Nidhi Q. "Analysis of bone activity of jaws using scintigraphy on patients before, during and after treatment with IV bisphosphonates: a retrospective study." Thesis, University of Iowa, 2009. https://ir.uiowa.edu/etd/240.

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Bisphosphonates are non-metabolized compounds with high affinity for bone mineral hydroxyapatite. These compounds are used in diagnosis and treatment of malignancies metastatic to bone. Currently, IV bisphosphonates are used to treat hypercalcemia of malignancy. There are also "off label" uses to prevent, minimize, or delay skeletal morbidity associated with metastatic bone disease. Osteonecrosis of the jaws is an intraoral complication that has been reported after administration of intravenous nitrogen-containing bisphosphonates. Bisphosphonate associated osteonecrosis (BON) may remain asympt
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15

Anadioti, Evanthia. "Internal and marginal fit Of pressed and cad lithium disilicate crowns made from digital and conventional impressions." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/2435.

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Objectives: The aim of the study was to evaluate in vitro the 3D and 2D marginal fit and 2D internal fit of CAD and Press all-ceramic crowns made from digital and conventional impressions. Methods: A dentoform replica tooth (#30) was prepared for an all-ceramic crown (Master Die). 30 impressions were made with PVS material; 30 definitive casts were poured in type IV gypsum. 30 LavaTM C.O.S. impressions were made; 30 resin models were produced. 30 crowns were waxed and pressed in lithium disilicate (IPS e.max Press) (15 fro
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16

Horak, E. "Pathology of tumour cell host interactions." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379940.

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17

Wolff, Ewan Douglas Stephens. "Oral pathology of the Archosauria bony abnormalities and phylogenetic inference /." Diss., Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/wolff/WolffE0507.pdf.

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18

Macfarlane, Gary John. "The epidemiology of oral cancer." Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357309.

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19

Savage, Anne Kay. "The pathology of hepatitis C virus infection." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362544.

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20

Mahmood, Tahir A. "The pathology and natural history of endometriosis." Thesis, University of Aberdeen, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277378.

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Endometriosis is a puzzling condition responsible for considerable morbidity. The literature is characterised by a large number of reports but there is surprisingly little agreement on the aetiology and pathophysiology. In particular the relationship between mild endometriosis and subfecundity is uncertain. The aim of the studies described in this thesis was to document the incidence, and symptomatology of endometriosis in the fertile and infertile population, to study the natural history of endometriosis in infertile women and to study folliculogenesis, fertilisation and pathophysiology of pe
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21

Abdelaal, Maged Mohamed Elsayed. "Effect of post- processing heat treatment on flexural strength of zirconia for dental applications." Thesis, University of Iowa, 2016. https://ir.uiowa.edu/etd/3031.

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Purpose: the purpose of this study was to evaluate the effect of annealing heat treatment on biaxial flexural strength and reliability of 3Y-TZP, sintered at various temperatures. Materials & methods: 3Y-TZP blanks were pre-sintered at 850°C for 2 hours and sliced into discs (20x1.2mm). Specimens were randomly assigned to 5 groups and subsequently sintered at various temperatures ranging from 1350°C to 1650°C for 2 hours. For each sintering temperature, specimens were divided into three treatment groups. One group (n=20) was left as-sintered as control. One group was air-abraded with 50 micron
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22

Scott, David 1964 Jan 11. "Virulence factors of oral anaerobic spirochetes." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=34446.

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The research work presented in this thesis involved the examination of several fundamental questions concerning the role of oral anaerobic spirochetes (OAS) in the etiology of periodontal disease (PD). OAS are unusual, helical, Gram-negative bacteria that are considered putative periodontopathogens due to numerical association with diseased sites and the enzymatic arsenal available to OAS that appears consistent with disease symptoms. T. denticola is the most commonly isolated OAS from periodontal pockets and as such is the focus of most investigations into the role of OAS in PD.<br>As free ir
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23

Murphy, Justin Thomas. "Radioresistance in oral squamous cell carcinoma." Thesis, University of Hull, 2008. http://hydra.hull.ac.uk/resources/hull:770.

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Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer accounting for approximately 6% of all cancers worldwide. However the distribution across the globe varies considerably. The majority of small tumours of the oral cavity and upper aerodigestive tract, in the absence of metastatic disease, can be successfully treated with surgery or radiotherapy. Despite this most small tumours of the oral cavity are now treated with surgery as the primary treatment modality with radiotherapy being reserved for adjuvant therapy, palliation or in patients unfit for surgery. Radiotherap
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24

Woolgar, Julia Anne. "Lymph node metastasis in oral cancer." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260368.

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25

Crooks, Gillian Mary. "Oral anticoagulation : a community based review." Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317444.

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26

Insalaco, Deborah Michelle. "Multiple oral re-reading for subjects with alexia." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/289086.

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This series of case studies explored the relationship between reading profiles and the benefits of text reading treatment. This research was motivated by the finding that some subjects with deep alexia read aloud words presented in a text context more accurately than words presented in isolation (Silverberg, Vigliocco, Insalaco, & Garrett, 1998). The benefit, which was specific to closed class elements, was consistent with a model of sentence production that hypothesizes that open and closed class elements are retrieved differently (Garrett, 1984, 1990). The treatment method used, Multiple Ora
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Alkindi, Mohammed. "Effects of soluble factors released by oral squamos cell carcinoma on osteoclasts." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103726.

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Objective: Bone invasion represent significant problem in managing head and neck cancers, however the mechanisms of interactions between oral squamous cell carcinoma (OSCC) and bone cells are poorly understood. We hypothesized that tumor cells can directly stimulate osteoclastogenesis. Methods: OSCC cell lines, bone-invasive BHY and metastatic but not bone-invasive HN were cultured and conditioned medium (CM) was collected. Osteoclast formation from RAW 264.7 mouse monocytic cell-line was assessed. Results: When RAW 264.7 were primed with receptor activator of nuclear factor κB ligand (RANKL)
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Gonzalez, Shawneen M. "Cortical bone thickness in the maxilla and mandible for mini-implant placement." Thesis, University of Iowa, 2008. http://ir.uiowa.edu/etd/36.

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Anand, Sumeet M. 1978. "The correlation between tumour volume and survival in oral cavity and oropharyngeal squamous cell carcinoma /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111587.

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The Tumour-Node-Metastasis (TNM) classification system of tumour stage does not always reflect the actual tumour mass present at diagnosis. Recent reports propose that volumetric analysis may allow improved stratification of disease recurrence and survival in head and neck squamous cell cancer (SCC). This study aims to assess the prognostic value of tumour volume on the outcome of patients with oral cavity and oropharyngeal SCC.<br>A retrospective review of 73 patients was completed. Tumours were outlined semi-automatically in digitized computed tomography scans, and volumes computed based on
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30

Fey, Marc E., Hugh W. Catts, Kerry Proctor-Williams, J. Bruce Tomblin, and Xuyang Zhang. "Oral and Written Story Composition Skills of Children With Language Impairment." Digital Commons @ East Tennessee State University, 2004. https://dc.etsu.edu/etsu-works/1776.

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In this study 538 children composed 1 oral and 1 written fictional story in both 2nd and 4th grades. Each child represented 1 of 4 diagnostic groups: typical language (TL), specific language impairment (SLI), nonspecific language impairment (NLI), or low nonverbal IQ (LNIQ). The stories of the TL group had more different words, more grammatical complexity, fewer errors, and more overall quality than either language-impaired group at either grade. Stories of the SLI and LNIQ groups were consistently stronger than were those of the NLI group. Kindergarten children with language impairment (LI) w
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Sheehy, Evelyn Catherina. "The oral microflora of children undergoing liver transplantation." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300430.

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32

Nurcombe, Heather Louise. "The role of neutrophils in the pathology of rheumatoid arthritis." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385092.

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33

Low, Wah Yun. "Psychological aspects of pelvic pathology, with specific reference to endometriosis." Thesis, University of Surrey, 1993. http://epubs.surrey.ac.uk/844415/.

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This study examines psychological aspects of pelvic pathology with specific reference to endometriosis, a gynaecological disease where tissues like the endometrium (tissues that lines the inside of the uterus) are found outside the uterus. Endometriosis is a cause of pelvic pain, excessive bleeding and infertility. The first aim of the study was to evaluate the hypothesis that patients with endometriosis have a different socio-demographic and psychological profile from other gynaecological patients. A second aim was to evaluate the hypothesis that psychological factors are more important than
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Kerbyson, Nicola Claire. "The prevalence and diagnosis of equine colonic mucosal pathology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/38934/.

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35

Athar, Saira. "Immortalization of human oral keratinocytes with defined genetic elements in the development of organotypic oral culture." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8690.

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Primary cell culture is limited by the increase in cellular levels of p16INK4a in response to an in vitro culture environment and, in conjunction with telomere shortening following cell division, presents a barrier to cellular proliferation. The use of transformed cell lines is limited for studies wherein the aim is to generate data akin to an in vivo environment as commonly such cell lines achieve their immortal benefits by down regulating important tumour suppressive mechanisms and inhibiting cell cycle checkpoints. Normal Human Oral Keratinocyte (NHOK) cells expressing shp16+hTERT were gene
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Gohari, Homayon, and Kamran Haddad. "Oral hälsa hos vuxna diabetiker." Thesis, Karlstad University, Faculty of Social and Life Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-2263.

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<p>Bakgrund: Diabetes är en kronisk sjukdom och mer än 150 miljoner i världen har sjukdomen. Diabetessjukdomen försämrar både den allmänna och den orala hälsan. Diabetikernas kunskaper om sjukdomens negativa effekter på munhälsan är bristfällig. Syfte: var att beskriva hur vuxna individers orala hälsa påverkas av diabetes och vad tandhygienister ska beakta vid en tandvårdsbehandling. Frågeställningar: Vilka är de orala komplikationerna hos vuxna individer med diabetes? Kan parodontitbehandling hos diabetiker ha positiva effekter på diabetessjukdomen? Vad bör tandhygienister särskilt ta hänsyn
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Mahrous, Ahmed. "The use of topical subgingival application of simvastatin gel in treatment of peri implant mucisitis : A pilot study." Thesis, University of Iowa, 2017. https://ir.uiowa.edu/etd/5561.

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Dentistry has come a long way from its humble beginnings. Like all other healthcare specialties, dentistry has evolved through the years. The understanding of physiology of dental health and disease has evolved allowing us to treat dental diseases much more efficiently. However not all dental problems are fully understood. Diseases that affect the bone and soft tissue around teeth and dental implants, also known as “periodontal” and peri-implant” diseases respectively, have proven to be among the least understood and challenging dental diseases to treat. Recent advancements in microbiology and
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Kidd, Mark Simon Geoffrey. "Relationship of Helicobacter pylori virulence to gastric pathology in the Western Cape." Doctoral thesis, University of Cape Town, 2000. http://hdl.handle.net/11427/3410.

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Includes bibliographical references.<br>The work presented in this thesis investigated virulence in Helicobacter pylori isolates of the Western Cape and related this virulent fingerprint to alterations in gastric cell physiology and cell cycle events. Initially, the "virulence profile" of 109 isolates from 86 patients with a spectrum of clinically significant gastroduodenal diseases was investigated.
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Sawair, F. A. "Prognostic indicators of outcome for oral squamous cell carcinoma." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390863.

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McKeown, S. T. W. "Regulation of epithelial phenotype by regionally defined oral fibroblasts." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269133.

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Gemenetzidis, Emilios. "The role of FOXM1 in oral squamous cell carcinoma." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/492.

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FOXM1 transcription factor regulates the expression of a multitude of genes, which are important for cell proliferation, mitosis, and differentiation. Although it is abundantly expressed in majority of human solid tumours, its role in early stages of human neoplasia remains unclear. Oral squamous cell carcinoma (OSCC) is characterized by sequential genomic alterations, which lead to invasive malignancy. In this study, it is shown that FOXM1 is significantly upregulated in early oral pre-malignant and OSCC tissues and cultured keratinocytes. Furthermore, the current study suggests that FOXM1B i
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Martin, Joanne Elizabeth. "Cellular pathology of the lower motor neuron in motor neuron disease." Thesis, Queen Mary, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266426.

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Osin, Peter. "Molecular pathology of special types of breast cancer and associated lesions." Thesis, Institute of Cancer Research (University Of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270833.

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44

Pryor, Wendy. "Pathology, professionalism, portfolios and progress." Thesis, The University of Sydney, 2010. http://hdl.handle.net/2123/7296.

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Abstract Community-driven standards of professionalism must be addressed, worldwide, at all levels of medical education. The imperative to implement robust strategies to ensure that doctors embrace these standards to justify the autonomy afforded to the medical profession has been a key concern of specialist medical colleges in recent years. Pathologists face unique challenges. Rapid technological change and increasing commercialisation have distanced them further than ever before from patients and other clinicians, resulting in negative stereotypes that impede understanding of professional ro
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Gagen, O. Yu. "Treatment of concomitant pathology of the oral cavity in patients with maxillofacial injury." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17823.

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46

Stewart, Barry. "Experimental scrapie : comparison of pathology following oral and other parenteral routes of infection." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/22659.

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The aim of this project was to determine the effect that route of infection has on the incubation period and terminal pathology of experimental scrapie. Infection was established either by injection into the peritoneum or the <i>biceps femoralis</i> of the leg, or orally by administration of the agent with food. As a secondary study an experiment was devised to investigate the possible transport of scrapie infectivity in the central nervous system (CNS) of mice lacking a functional <i>prn-p</i> gene. The primary study was carried out using a combination of immunohistochemistry, histopathology
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New, James Stewart. "Plant-made oral vaccines evaluation of capsules." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/493.

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Antigen expression through the Chloroplast Transformation Technology (CTT) produces bioencapsulated subunit-vaccines, capable of eliciting immune responses when delivered orally. Considerable challenges to effective plant-based vaccines are the normalization of dosage and preservation of accumulated antigen, which is complicated by variable high water content and protease activity. This study critically examines the efficacy of lyophilization in dehydrating plant-tissues and preserving plant-derived antigens with vaccine potential. Lyophilization was optimized through gravimetric analysis usin
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Waters, Nicole Poythress. "Development of post-traumatic osteoarthritis models to evaluate effects of impact injury on joint health for clinical disease treatment and prevention." Thesis, University of Missouri - Columbia, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10180779.

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<p>Osteoarthritis is one of the most common, debilitating, musculoskeletal diseases in the world. Currently, there is no cure. It is well-known that a traumatic, joint injury increases the risk of developing post-traumatic osteoarthritis (PTOA). Therefore, in order to improve clinical treatment and prevention strategies for post-traumatic osteoarthritis (PTOA), a series of translational studies were conducted to develop research models to evaluate the effects of impact injury. </p><p> The first section of this dissertation (Ch. 1&ndash;2) provides a comprehensive introduction and literature
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Martin, Ryan Daniel. "T1alpha interacts with Myh9, a nonmuscle myosin, in type 1 lung epithelial cells." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21213.

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Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>T1α (also known as Podoplanin), is a highly expressed gene found in lung alveolar type I (ATI) epithelial cells and in several other organ systems including lymphatic vessels and kidney. T1α is necessary for proper alveolar develop
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Sonderup, Mark Wayne. "A clinicopathological cohort study of liver pathology in 301 patients with HIV/AIDS." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3468.

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