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Dissertations / Theses on the topic 'Oral precancers'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Hamadah, Omar. "Predicting the behaviour of oral precancer lesions." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442328.

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2

Oliver, Richard John. "Quantification of cell cycle markers in oral precancer." Thesis, University of Glasgow, 1998. http://theses.gla.ac.uk/2691/.

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The overall aims of the studies were to obtain objective measures of oral precancerous lesions based upon studies of the cell cycle and to investigate these parameters as possible prognostic indicators with regard to malignant transformation of these lesions. The majority of the precancerous lesions in the present study were dysplastic. These are the lesions which cause the greatest concern clinically with regard to malignant transformation. The first part of the study investigated the S-phase, growth fraction and the relationship of these to each other and with the degree of dysplasia with th

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3

Zahrani, Ahmed Abdulrahim. "Cell cycle associated markers in oral cancer and precancer." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297573.

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4

Green, Rachel. "Patient and professional views and experience of oral precancer." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2270.

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Oral precancer (OPC) is a collective term for a number of disorders that may precede oral cancer. Treatment is aimed at preventing malignant transformation however, this is complicated by a lack of robust evidence concerning both treatment effectiveness and future cancer risk. Uncertainties surrounding prognosis and treatment options might be expected to impact on a patient’s experience of their disease, as well as creating challenges for their management. The aim of this research was to explore the experience of OPC through the eyes of the patient and clinician to assess the impact of living

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5

Abu, Eid Rasha Fadel. "Analysis and quantification of oral cancer and precancer growth patterns." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695352.

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6

Gaballah, Kamis Younis. "Novel experimental strategies to destroy oral cancer and precancer and residual disease." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582637.

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Oral cancer is a major healthy problem, with about 400,000 new cases diagnosed annually worldwide. The disease is characterised by consistently low 5-year survival rate that related to the significant recurrence rate. The recurrence may correlate to the presence of genetically and histologically altered tissues with a higher risk of malignant transformation (Dysplasia) or the residual malignant cells may remain in the body after surgery to remove a tumour (Residual disease).This thesis examines the efficacy of conditionally replicating adenoviruses (CRAds), to lyse epithelia that show mild, mo

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7

Michelsen, Carmen. "The use of microsatellite markers to assess the malignant potential of oral precancerous lesions and oral lichen planus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq24207.pdf.

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8

Lim, Kenneth. "Screening for oral cancer and precancer in general dental practice : evaluation of machine learning software in the identification of high risk groups." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407951.

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9

Chaves, Filipe Nobre. "Immunohistochemistry analysis of hypoxia induced factor-1α in oral squamous cell carcinoma and potentially malignant lesions." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11046.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>IntroduÃÃo: HipÃxia constitui em uma caracterÃstica comum de tumores sÃlidos, como em cÃnceres de cabeÃa e pescoÃo, e nessas condiÃÃes, uma via de sinalizaÃÃo envolvendo um regulador de resposta a oxigÃnio, chamado de Fator Induzido por HipÃxia-1 (HIF-1) tem-se destacado, na tentativa de permitir uma melhor compreensÃo sobre a biologia tumoral do cÃncer. Objetivo: Investigar o papel do HIF-1 em carcinoma epidermÃide oral (CEO) e em lesÃes potencialmente malignas que apresentam displasia epitelial oral (DEO). MÃtodos: Est

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10

Lin, Yen-Hung, and 林彥宏. "Expression of P34cdc2 in oral precancers and oral squamous cell carcinomas." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/35697407564024992613.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>96<br>Background: Overexpression of p34cdc2 has been demonstrated in a variety of human cancers and found to be significantly associated with the tumor size, lymph node metastasis, clinical stage, or prognosis of these cancers. Methods: In this study, we examined the expression of p34cdc2 in 81 specimens of oral squamous cell carcinoma (OSCC), 95 specimens of oral epithelial dysplasia (OED; 29 mild, 43 moderate, and 23 severe OED cases), and 14 specimens of normal oral mucosa (NOM) by immunohistochemistry. The cytoplasmic p34cdc2 labeling indices (LIs) in OSCC, OED,

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11

Lin, Yen-Hung. "Expression of P34cdc2 in oral precancers and oral squamous cell carcinomas." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2506200819254900.

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12

Chuan-Hang, Yu. "Expression of metastasis-associated protein 1 in oral precancers and oral squamous cell carcinomas." 2005. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1306200511202300.

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Yu, Chuan-Hang, and 余權航. "Expression of metastasis-associated protein 1 in oral precancers and oral squamous cell carcinomas." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/10773043553538016130.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>93<br>Background: Overexpression of metastasis-associated protein 1 (MTA1) has been demonstrated in a variety of human cancers and found to be significantly associated with the tumor size, lymph node metastasis, clinical stage, tumor invasion, or prognosis of these cancers. Methods: In this study, we examined the expression of MTA1 protein in 74 specimens of oral squamous cell carcinoma (OSCC), 100 specimens of oral epithelial dysplasia (ED; 33 mild, 44 moderate, and 23 severe ED cases), and 21 specimens of normal oral mucosa (NOM) by immunohistochemistry. The cytop

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14

Tsai, Tung-Chieh, and 蔡東潔. "Expression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) in oral precancers and cancers." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/12138755397381105483.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>95<br>BACKGROUND: Overexpression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) has been found to be significantly associated with the tumor size, lymph node metastasis, clinical or pathological stage, and prognosis of a variety of human cancers. METHODS: This study examined the expression of RCAS1 in 84 specimens of oral squamous cell carcinoma (OSCC), 106 specimens of oral epithelial dysplasia (OED, 32 mild, 44 moderate, and 30 severe OED cases), and 20 specimens of normal oral mucosa (NOM) by immunohistochemistry. RESULTS: We found that the me

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Tsai, Tung-Chieh. "Expression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) in oral precancers and cancers." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1907200717351300.

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16

Ya-HanChang and 張雅涵. "Role of Exosomes from Oral Precancer Associated Fibroblasts in Oral Cancer Progression." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/as75d8.

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碩士<br>國立成功大學<br>口腔醫學研究所<br>103<br>In our previous study, we isolated and cultured several fibroblast sets from oral cancer patients’ normal, pre-cancer, cancer tissues. We found proliferation rate and α-SMA expression level, a marker of activated fibroblasts, were higher in pre-cancer associated fibroblasts than in normal fibroblasts. The conditioned media from pre-cancer associated fibroblasts have higher cancer cell migration promoting abilities than those from normal fibroblasts. Moreover, we purified exosomes from the conditioned media of fibroblasts and found the size of exosomes derived

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Sz-ShiuanChen and 陳思璇. "MicroRNA-133a inhibits oral precancerous malignant transformation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/58128422149047669716.

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碩士<br>國立成功大學<br>口腔醫學研究所<br>100<br>Oral squamous cell carcinoma (OSCC) is the fourth leading cause of male cancer death in Taiwan. OSCC development usually involves multistep progression from normal oral mucosa changing to oral precancerous lesions and then changing to OSCC. In which, oral verrucous hyperplasia (VH) is one of oral precancerous lesions with relatively high malignant transformation potential. Therefore, identification of molecular markers which can predict disease progression is necessary. MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides that can funct

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Yu, Chuan-Hang, and 余權航. "Photodynamic therapy and cryotherapy for oral precancerous lesions." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/24384281380854910580.

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博士<br>國立臺灣大學<br>臨床牙醫學研究所<br>96<br>Background: Oral leukoplakia (OL), oral erythroleukoplakia (OEL), and oral verrucous hyperplasia (OVH) are three common oral precancerous lesions. In this study, we used two conservative treatment modalities, topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) and cotton-swab cryotherapy (CSC), for treatment of these lesions. In addition, we also used immunohistochemistry (IHC) to study whether the expression of apoptosis-associated proteins in oral precancerous lesions before PDT could be a biomarker to predict the treatment outcomes of topi

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Yu, Chuan-Hang. "Photodynamic therapy and cryotherapy for oral precancerous lesions." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-0906200810300400.

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20

Chen, Pai-Li, and 陳百立. "Study of Malignant Transformation of Oral Mucosal Precancerous Lesions." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/94070807489783175194.

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碩士<br>高雄醫學大學<br>牙醫學研究所碩士班<br>94<br>Objective As the areca quid consumption population is increasing in Taiwan , the incidence of and mortality from oral cavity cancer are climbing. The development of oral cavity cancer is a progressive procedure. Early detection of oral precancerous lesions or premalignant conditions with conservative treatment and close follow-up should decrease the possibility of subsequent malignant transformation of these lesions. The purposes of this study were to discover the characteristic features of common oral precancerous lesions and premalignant conditions , to

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21

Lin, Jiun-Sheng, and 林鈞盛. "Detection of oral cancer and precancerous lesion by Methylene blue." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/02993730811694348507.

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碩士<br>國立陽明大學<br>臨床牙醫學研究所<br>92<br>Oral cancer is a fatal disease which accounts for the 5th highest incidence of malignancy of male and 7th in general population. five years survival is also below 50% with no sign of recent improvement, survival is strongly influenced by the stage of the disease at initial presentation, oral cancer is common due to the prevalence of betel nut chewing and smoking in Taiwan. The five years survival rate of early treated oral cancer is significantly better than the late one. Therefore how to detect oral cancer in early stage is important. Methylene blue is a diag

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22

Lu, Chia-Fang, and 呂佳芳. "Macrophage associated with oral precancerous lesions and squamous cell carcinoma." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/02799264108815185360.

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碩士<br>長庚大學<br>顱顏口腔醫學研究所<br>94<br>Aim: To study the correlation between the infiltrating macrophage count (IMC) and the progression and prognosis of oral squamous cell carcinoma (OSCC) and to evaluate whether the IMC can be a prognostic predictor for OSCCs. Methods: Ninety-two specimens of OSCC, 105 specimens of oral epithelial dysplasia (OED; 38 mild, 43 moderate, and 24 severe OED cases), and 15 specimens of normal oral mucosa (NOM) were immunostained with antibodies against CD 68. IMCs were calculated by counting the CD 68-positive cells in sections and expressed as the number of macrophages

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23

Chiu, Yi-Ten, and 邱怡騰. "Association of Genetic Polymorphisms of Inflammatory Related Cytokines with the Risk of Oral Precancer Lesions and Oral Cancer." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/39659194785009659233.

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碩士<br>國立中山大學<br>生物醫學研究所<br>96<br>Clinical and epidemiological studies support a strong association between chronic inflammation and cancer. Inflammatory related cytokines, such as IL-1α, IL-1RN, IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α and TGFβ-1, might play important role in carcinogenesis of oral squamous cell carcinoma (OSCC). Two case-control studies were carried out to evaluate the association of 16 various polymorphisms of 9 inflammatory-related genes with the risk for OSCC and the risk for betel quid (BQ)-related oral precancer lesions (OPL) and BQ-related OSCC. Then the association betwee

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24

Nieman, Linda Tae. "Early detection of curable precancerous lesions in the oral cavity using polarized reflectance spectroscopy." Thesis, 2004. http://hdl.handle.net/2152/1281.

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25

Lin, Chen-Yu, and 林宸羽. "Characterization of Oral Precancerous Lesions Based on Higher Harmonic Generation Microscopy." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/94495194737908246095.

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碩士<br>國立臺灣大學<br>光電工程學研究所<br>101<br>Oral cancer is the fourth most common cause of male cancer death in Taiwan and ranks first among the cancers that affect the young male population. About 5,400 new oral cancer cases are reported in Taiwan each year. However, the five-year survival rates of oral cancer patients are still low. The only way to address this problem is early diagnosis. In the oral cancer diagnosis, surgical biopsy followed by pathological exam is the standard operating procedure. But, surgical biopsy is always accompanied by pain, bleeding, trauma, and spreading of cancer cells.

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Hsiung, Jou-An, and 熊柔安. "Correlation between oral precancerous lesions and global DNA hypomethylation in epithelial cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/2248ev.

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碩士<br>國立陽明大學<br>牙醫學系<br>103<br>Oral squamous cell carcinoma (OSCC) is the 5th leading cause of cancer death in Taiwan with an unsatisfied overall 5-year survival rate around 50% up to date. Nonetheless, the characteristic that invasive OSCC often precedes by the presence of premalignant lesions makes it a potentially targetable period for early detection and even management to prevent disease progression. Aberrant DNA methylation has been widely reported in various cancers. Recently, genome-wide hypomethylation are usually observed on the repetitive sequences of chromosome before the occurrenc

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Wang, Yuan-Bang, and 王源邦. "The Association of XRCC1 Polymorphisms with the Risk of Oral Precancerous Lesions." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/44092908605249509015.

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碩士<br>國立中山大學<br>生物科學系研究所<br>100<br>Betel quid（BQ）chewing is recognized as a major risk factor for oral precancerous lesions（OPLs）in Taiwan. The compositions of Betel quid could cause DNA damage. X-ray repair cross complementing Group 1（XRCC1）plays a crucial role in the process of DNA repair. Polymorphisms in XRCC1 gene may affect DNA repairing ability and modulate the susceptibility of OPLs. The aim of this study was to investigate the association of XRCC1 genetic variants with the risk of BQ-related oral precancerous lesions, including oral leukoplakia（OL） and oral submucous fibrosis ( OSF ).

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Cheng, Wan-Yueh, and 鄭婉月. "The Prevalence of Oral Precancerous Lesion in Anle District Keelung City 2012." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/89009070373078149365.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>101<br>According to the statistics of the standardized death rate of major cancers for the past 100 years by the Department of Health, Executive Yuan of Taiwan, oral cancer rate grew up 18.1% more than 10 years. In the county-level statistics of major cancer death in year 2011, oral cancer of male is the fourth leading cause of death in Keelung. Due to the risk factors of betel-quid and tobacco consumption, oral cancer is a growing threat to public health. This study focuses on oral mucosal lesions screening data in Anle District of year 2012, collected from the canc

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Chen, Chiu-Chin, and 陳秋琴. "The Association between Diet and Oral Precancer Lesions in Indigenous Communities of the Southern Pingtung." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/35790054921574693026.

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碩士<br>高雄醫學大學<br>口腔衛生科學研究所碩士在職專班<br>98<br>Abstract Background: Oral mucosal lesions and betel quid chewing, drinking, smoking, and their associations have been intensively studied in the past; in addition, despite many reports of various nutrients related to the incidence of oral carcinoma from abroad. Limited studies have been investigated the relationship of dietary habits and oral mucosal lesions in Taiwan. Study objective: To examine the eating habits of indigenous communities and the association with precancer lesions. Methods: In this study, the Department of Health, Executive

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Wang, Yu-Tsang, and 王昱蒼. "The Association of DNA Repair Gene Polymorphisms with Oral Precancerous Lesions and Conditions." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/16792415084275345256.

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碩士<br>中國醫藥大學<br>公共衛生學系碩士班<br>99<br>INTRODUCTION: According to the Department of Health, Executive Yuan, R.O.C. and the Bureau Health Promotion, Department of Health, R.O.C. (TAIWAN), oral cancer in men was the fourth leading cause of death from cancer and the fourth high incidence among cancers. Although oral precancerous lesions and conditions (OPLC) may not harmful to health, it could result in malignant transformation to oral cancer. DNA single nucleotide polymorphisms (SNPs) may alter structures of the DNA repair enzyme and the capacity of repair. The defects of DNA repair mechanisms may c

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31

Jin, H. L., and 金紘立. "Differentiation of oral precancerous tissues based on the analyses of optical scattering property." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/00489311992420262629.

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碩士<br>長庚大學<br>電機工程學系<br>100<br>Optical coherence tomography (OCT) has been widely used for biomedical applications due to noninvasive, high resolution imaging trchnique for biomedical applications. However, in previous reports, OCT is still difficult to use in the diagnosis of oral precancerous stages, including mild dysplasia and moderate dysplasia. In clinical applications, early diagnosis and treatment of oral cancer can greatly improve the survival rate. Therefore, in this study, we propose a new approach to differentiate the oral precancerous stages based on the evaluation of the optical

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32

Liao, Li-Jen, and 廖立人. "The expression of p53 and PTTG1 in oral precancerous lesions, oral squamous cell carcinomas, and outcome—a preliminary study." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/19875884767151636916.

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碩士<br>國立臺灣大學<br>預防醫學研究所<br>96<br>Purpose: The aim of this study is to explore the expression of two molecular markers (p53 & PTTG1) in oral cancer tumorgenesis and to explore their association with the prognosis of patients with oral precancerous lesion and oral cancer. Methods: One hundred and forty one cases of formalin-fixed, paraffin-embedded specimens were collected and classified as patients group, including primary oral precancerous lesions (n=82) and squamous cell carinomas without distant metastasis (n=43). These patients received operation at the Department of Otolaryngology or Oral

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Liao, Li-Jen. "The expression of p53 and PTTG1 in oral precancerous lesions, oral squamous cell carcinomas, and outcome -a preliminary study." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2606200822223900.

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Chen, Huang-Hsu. "Expression of human telomerase reverse transcriptase in oral squamous cell carcinomas and precancerous lesions." 2005. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1606200510484800.

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Chen, Huang-Hsu, and 陳皇旭. "Expression of human telomerase reverse transcriptase in oral squamous cell carcinomas and precancerous lesions." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/48952696926311611697.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>93<br>Background: Overexpression of telomerase activity or human telomerase reverse transcriptase (hTERT) mRNA has been demonstrated in a variety of human cancers and found to be associated with the tumor size, lymph node metastasis, clinical stage, recurrence, or prognosis of these cancers. Methods: In this study, we examined the expression of hTERT protein in 82 specimens of oral squamous cell carcinoma (OSCC), 116 specimens of oral epithelial dysplasia (OED), and 21 specimens of normal oral mucosa (NOM) by immunohistochemistry. The cytoplasmic and nuclear hTERT s

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Lin, Hsiu-Ying, and 林秀英. "The Effectiveness of Case Management Model on Patients with Precancerous Lesions to Oral Cancer." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/64112008387439186817.

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碩士<br>長庚科技大學<br>護理研究所在職專班<br>102<br>Patients with precancerous lesions to oral cancer may have insufficient knowledge, poor attitudes, ineffective oral cancer prevention behaviors, uncertainty, anxiety, and unmet information needs during the diagnostic period. The purpose of this study was to determeine the effectiveness of case management on knowledge, attitudes, cancer prevention behavior, uncertainty, anxiety and information needs in patients with precancerous lesions to oral cancer during the diagnosed period. An experimental, repeated measures design with an intervention and comparison gr

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Nieman, Linda Tae Sokolov Konstantin Raizen Mark George. "Early detection of curable precancerous lesions in the oral cavity using polarized reflectance spectroscopy." 2004. http://wwwlib.umi.com/cr/utexas/fullcit?p3143437.

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Tseng, Meng-Kai, and 曾盟凱. "Development of RF light emission system for PDT studies on hamster oral precancerous lesions." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/81397203771922595952.

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碩士<br>中原大學<br>生物醫學工程研究所<br>99<br>Photodynamic therapy (PDT) is a promising adjuvant therapy to treat oral cancers. PDT is commonly performed with single high light dose (SHLD) exposure. Some literatures, however, reported that fractionated low light dose (FLLD) PDT is more effective in cancer treatment. This study proposes utilizing implantable light devices drivable by radio frequency (RF) transmitters to treat oral pre-cancer in hamster pouches to explore if the RF technique in conjunction with the FLLD is feasible to be used in clinical applications. A lighting system consisting of a miniat

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Lee, Hung-Yi, and 李泓毅. "Detection of oral precancerous lesion by using polarization-sensitive optical coherence tomography: mice model." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/86r7xy.

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Huang, Hsin-I., and 黃馨儀. "A anlysis of the relationship between p53 and COX-2 gene polymorphism to oral squamous cell carinoma, and oral precancerous lesion." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/35838711794593058644.

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碩士<br>高雄醫學大學<br>口腔衛生科學研究所碩士班<br>95<br>Background: Inflammation and imbalances between cell proliferation and cell death are two important key factors for cancer development. COX-2 and p53 genes play important roles in inflammation and cell cycle regulation. Recent reports suggest that polymorphisms of p53 at codon 72 and COX-2 at promoter sequence -765G/C may act as risk factors for a variety of cancers. However, the associations between these two polymorphisms, oral precancerous lesions (OPL), and oral squamous cell carcinoma (OSCC) are unclear. In the present study, our aims were to determi

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Chou, Wen-Pin, and 周文彬. "Studies of mitochondrial DNA 4977bpdeletion in microdissected oral cancer and precancer lesions by Real-Time quantitative PCR." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/67563417154001762565.

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碩士<br>國立成功大學<br>分子醫學研究所<br>91<br>Oral cancer is the fifth leading cause of cancer deaths among men in Taiwan and is closely associated with areca quid chewing habit. Recent studies showed that mitochondrial DNA (mtDNA) mutations occur in various tumors including oral cancers and that the accumulation of mtDNA deletions could be an important contributor during carcinogenesis. We have analyzed mtDNA deletions by pairwise comparisons among oral cancer, precancerous cells and their adjacent submucosal stroma tissues in 16 patients with areca quid history and 9 patients no areca quid

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Chang, Chia-Chuan, and 張家銓. "Expression of cellular inhibitor of apoptosis protein 1 in oral squamous cell carcinomas and precancerous lesions." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/73480865892851888000.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>96<br>Background: Overexpression of cellular inhibitor of apoptosis protein 1 (cIAP-1) has been demonstrated in a variety of human cancers and found to be associated with the lymph node metastasis, clinical stage, recurrence, or prognosis of these cancers. Methods: In this study, we examined the expression of cIAP-1 protein in 73 specimens of oral squamous cell carcinoma (OSCC), 76 specimens of oral epithelial dysplasia (OED), and 31 specimens of normal oral mucosa (NOM) by immunohistochemistry. The cytoplasmic cIAP-1 labeling indices (LIs) in OSCC, OED, and NOM sam

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Chang, Chia-Chuan. "Expression of cellular inhibitor of apoptosis protein 1 in oral squamous cell carcinomas and precancerous lesions." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2606200816171200.

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Lai, Hung-Lin, and 賴泓霖. "Analysis of D-loop Sequence and Copy Number of Mitochondrial DNA in Oral Cancer and Precancer Tissues and Cell lines." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/cycyy2.

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碩士<br>國立成功大學<br>口腔醫學研究所<br>92<br>Oral cancer is the fifth leading cause of cancer death in Taiwanese male population. In a previous study, a quantitative alteration of deleted mtDNA 4977bps deletion was detected in the progression of oral carcinogenesis. The displacement loop (D-loop) of mitochondria genome plays important role in mtDNA replication and transcription. A high mutation rate within the region has been reported in other tumors. In the present study, we analyzed mutations in the D-loop region of mtDNA using laser microdissected paired normal, cancer and precancer cells from pati

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Tsai, Chung-Shing, and 蔡忠勳. "Association of CTLA-4 gene and ACE gene polymorphism with oral precancerous lesion in Aborigines of Southern Taiwan." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/16796681707067189575.

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碩士<br>高雄醫學大學<br>牙醫學研究所<br>96<br>Background Oral precancerous lesion (OPL) is a chronic disease that may affect the entire oral cavity. It has been indicated to be associated with inflammatory and immune reaction. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T-lymphocyte activation, it plays an important role in immune tolerance and energy. Angiotensin-converting enzyme (ACE) is expressed in a wide range of tissues. It may be involved in various steps of the inflammatory response. We therefore investigated the role of the CTLA-4 gene and ACE gene polymorphism

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Lin, Chien-Ling, and 林倩伶. "Analysis of different lymphocyte subsets and activation on healthy people, patient with precancerous lesion and oral cancer in Taiwan." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/68598987549937586792.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>92<br>The lymphocyte subsets (CD4/CD3-T cell, CD8/CD3-T cell, CD19-B cell, CD56-NK cell) and lymphocyte activation antigen ( CD69, CD25) in the peripheral blood (2 ml) of healthy men and women in Taiwan (male: 80, female:50), per cancerous people (28 patients) and oral cancer people ( male: 87, female : 10) were analyzed using two-color flow cytometry. The data were analysised and the three main results were found. First, the sex, age, race can influence the distribution of lymphocyte subsets and activation. The distribution of CD4/CD3-T cell in women was higher tha

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Chi, Hsin-I., and 紀欣怡. "The COX-2 expression of oral cancer and its precancerous lesions and the inhibition of propolis on COX-2." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/59503365216970145479.

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碩士<br>中山醫學大學<br>營養科學研究所<br>90<br>Oral cancer has been one of the ten major cancers in Taiwan. This study was to know the COX-2 expression in precancerous lesions tissue and to evaluated the inhibition of propolis on COX-2 expression. By Western blot assay, the COX-2 expression was great in the oral cancer tissue followed by leukoplakia and OSF. The levels of COX-2 expression also showed positive correlation with the severity of each lesions. Immunohistochemistry analysis showed that COX-2 expression in oral cancer tissue was very strong and much higher than in leukoplakia and OSF tissue. Furth

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Tsai, Wei-Chi, and 蔡瑋琪. "The association between polymorphisms of N-acetyltransferase genes NAT1, NAT2, cigarette smoking, alcohol consumption, betel chewing and oral precancerous conditions." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/46093650899201130893.

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碩士<br>中國醫藥大學<br>公共衛生學系碩士班<br>99<br>Background : The incidence and mortality of oral cancer have increased quickly in the past five years in Taiwan. For men, oral cancer not only occurs at high incidence but also occurs at an early age. Therefore, if we can detect the oral precancerous conditions early and receive the treatment in time or follow up intensively, then it would be of great help on people’s health and the development of our country''s economy. Some studies have been reported that the association between cigarette smoking, alcohol consumption, betel chewing and the risk of

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Liu, Han-Pang, and 劉漢邦. "Cytochrome P450 2J2 gene G-50T polymorphism and angiotensin-converting enzyme gene insertion/deletion polymorphism in oral cancer and precanceous patients." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/58122063463122709357.

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碩士<br>高雄醫學大學<br>牙醫學研究所<br>97<br>Objective： Angiotensin-converting enzyme (ACE) is expressed in a wide range of tissues. It may be involved in various steps of the inflammatory response. Cytochrome P450(CYP)2J2 metabolizes arachidonic acid to epoxyeicosatrienoic acids(EETs). The EET are potent inhibitors of inflammation. We want to investigate the connection among ACE I/D gene polymorphism, CYP2J2 G-50T gene polymorphism , oral cancer patient and oral precancer patient compared with non-oral mucosal lesion subject with betel nut chewing habit control group. We also test the hypothesis that ACE

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Chiu, Fu-ching, and 邱釜靖. "Analysis of Galectin-1 and E-FABP expression in oral cancer and high-risk precancerous tissues by immunohistochemical and immunofluorescent assay." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/41609063995318751949.

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碩士<br>國立成功大學<br>口腔醫學研究所<br>95<br>Oral squamous cell carcinoma (OSCC) is an invasive lesion and is the most common cancer in head and neck region. The development and progression of OSCC is thought to be a multi-step process in which accumulation of damages to genes occurred through clonally evolution. In the carcinogenesis process, the normal epithelium will transform into precancerous lesions (PML), and then some of these lesions may get worse to OSCC. Among these precancerous transformations, verrucous hyperplasia and severe dysplasia, and carcinoma in situ are thought to be must intriguing

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