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1

Finberg, L. "Oral Rehydration Therapy." Pediatrics in Review 8, no. 9 (March 1, 1987): 278. http://dx.doi.org/10.1542/pir.8-9-278.

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2

Finberg, Laurence. "Oral Rehydration Therapy." Pediatrics In Review 8, no. 9 (March 1, 1987): 278. http://dx.doi.org/10.1542/pir.8.9.278.

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The Committee on Nutrition of the American Academy of Pediatrics strongly supports the concept of the use of the oral route for rehydration and maintenance hydration of infants with enteritis as reviewed in this issue by Santosham et al. We place emphasis more forcefully on distinguishing the different stages of physiologic disturbance in such infants which, therefore, slightly changes our emphasis in the recommendations for therapy. Even for mild dehydration, three stages are recognized: a state of clinical dehydration requiring rehydration, a maintenance fluid stage after hydration is achieved, and an early refeeding stage in which nutrition is restored. These stages may merge into one another quickly, and in some patientsthe rehydration period may not ever present.
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3

FINCH, MICHAEL H., and KABIR M. YOUNOSZAI. "Oral Rehydration Therapy." Southern Medical Journal 80, no. 5 (May 1987): 609–13. http://dx.doi.org/10.1097/00007611-198705000-00015.

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4

&NA;. "Oral Rehydration Therapy." Journal of Pediatric Gastroenterology and Nutrition 5, no. 1 (January 1986): 6–8. http://dx.doi.org/10.1097/00005176-198601000-00003.

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5

DAVIES, M. K. "Oral rehydration therapy." Archives of Disease in Childhood 84, no. 3 (March 1, 2001): 199. http://dx.doi.org/10.1136/adc.84.3.199.

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6

Casteel, Helen B., and Stephen C. Fiedorek. "Oral Rehydration Therapy." Pediatric Clinics of North America 37, no. 2 (April 1990): 295–311. http://dx.doi.org/10.1016/s0031-3955(16)36869-9.

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7

Greenough, WilliamB. "Oral rehydration therapy." Lancet 345, no. 8964 (June 1995): 1568–69. http://dx.doi.org/10.1016/s0140-6736(95)91112-x.

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8

Bender, Brenda J., Philip O. Ozuah, and Ellen F. Crain. "Oral Rehydration Therapy." Pediatric Emergency Care 23, no. 9 (September 2007): 624–26. http://dx.doi.org/10.1097/pec.0b013e318149f66f.

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9

Greenough, William B. "Oral Rehydration Therapy." Infectious Diseases in Clinical Practice 7, no. 2 (February 1998): 97–100. http://dx.doi.org/10.1097/00019048-199802000-00008.

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10

Santosham, Mathuram. "Oral Rehydration Therapy." Archives of Pediatrics & Adolescent Medicine 156, no. 12 (December 1, 2002): 1177. http://dx.doi.org/10.1001/archpedi.156.12.1177.

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11

Farthing, M. J. G. "Oral rehydration therapy." Pharmacology & Therapeutics 64, no. 3 (January 1994): 477–92. http://dx.doi.org/10.1016/0163-7258(94)90020-5.

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12

Molla, Abdul Majid. "IMPROVED ORAL REHYDRATION THERAPY." Journal of Pediatric Gastroenterology & Nutrition 27, no. 2 (August 1998): 245. http://dx.doi.org/10.1097/00005176-199808000-00036.

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13

Larrauri, Selene Alvarez. "Oral rehydration therapy promotion." Promotion & Education 1, no. 4 (December 1994): 22–26. http://dx.doi.org/10.1177/102538239400100412.

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14

Wittenberg, D. F., S. Ramji, and M. Broughton. "Oral rehydration therapy revisited." Lancet 337, no. 8744 (March 1991): 798–99. http://dx.doi.org/10.1016/0140-6736(91)91425-t.

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15

BARNESS, LEWIS A. "Rehydration Therapy." Pediatrics 75, no. 4 (April 1, 1985): 802. http://dx.doi.org/10.1542/peds.75.4.802.

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To the Editor.— A significant change, as evidenced by recent advertisements, has been made in the composition of Pedialyte oral rehydration solutions. Pedialyte, flavored or unflavored, now contains 45 mEq of sodium per liter (an increase of 15 mEq) and 2.5% glucose (a decrease of 2.5%), and it is suitable for maintenance as well as mild dehydration. The sodium content of Pedialyte RS has been increased to 75 mEq/L, suitable for initial repair of losses of moderate or severe diarrhea, but it should be used with caution in any maintenance regimen in young infants.
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16

Wheby, M. S. "Oral Rehydration Therapy in Cholera." Clinical Infectious Diseases 59, no. 11 (August 25, 2014): 1654–55. http://dx.doi.org/10.1093/cid/ciu676.

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17

Elliott, Elizabeth. "Oral rehydration therapy: applied physiology." Clinical Medicine 8, no. 3 (June 1, 2008): 296–97. http://dx.doi.org/10.7861/clinmedicine.8-3-296.

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18

Brown, Joel D. "Oral Rehydration Therapy for Diarrhea." Military Medicine 150, no. 11 (November 1, 1985): 577–81. http://dx.doi.org/10.1093/milmed/150.11.577.

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19

Hirschhorn, Norbert, and William B. Greenough. "Progress in Oral Rehydration Therapy." Scientific American 264, no. 5 (May 1991): 50–56. http://dx.doi.org/10.1038/scientificamerican0591-50.

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20

Ebrahim, G. J. "Looking beyond oral rehydration therapy." BMJ 295, no. 6608 (November 14, 1987): 1222–23. http://dx.doi.org/10.1136/bmj.295.6608.1222.

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21

Michell, A. R. "Oral and parenteral rehydration therapy." In Practice 11, no. 3 (May 1989): 96–99. http://dx.doi.org/10.1136/inpract.11.3.96.

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22

Rolston, D. D. K., M. J. G. Farthing, M. L. Clark, and A. M. Dawson. "Citrate in oral rehydration therapy." Gut 26, no. 4 (April 1, 1985): 429. http://dx.doi.org/10.1136/gut.26.4.429.

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23

Leung, Alexander K. C., Pauline Darling, and Claude Auclair. "Oral rehydration therapy — a review." Journal of the Royal Society of Health 107, no. 2 (April 1987): 64–67. http://dx.doi.org/10.1177/146642408710700210.

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24

Sachdev, H. P. S., and S. K. Bhargava. "Oral rehydration therapy of neonates." Indian Journal of Pediatrics 52, no. 5 (September 1985): 469–74. http://dx.doi.org/10.1007/bf02751019.

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25

Edwards, R. K. "Oral and intravenous rehydration therapy." BMJ 303, no. 6814 (November 30, 1991): 1402–3. http://dx.doi.org/10.1136/bmj.303.6814.1402-d.

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26

Neumann, Alfred K. "Anthropology and oral rehydration therapy." Social Science & Medicine 27, no. 1 (January 1988): 117–18. http://dx.doi.org/10.1016/0277-9536(88)90169-4.

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27

Erdoğan, Özlem, Bilge Tanyeri, Emel Torun, Erdem Gönüllü, Hüseyin Arslan, Ufuk Erenberk, and Faruk Öktem. "The Comparition of the Efficacy of Two Different Probiotics in Rotavirus Gastroenteritis in Children." Journal of Tropical Medicine 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/787240.

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Objectives. The aim of the study is to compare the clinical effectiveness of the probiotics—Saccharomyces boulardiiandBifidobacterium lactis—in children who had been diagnosed with rotavirus gastroenteritis.Materials and methods. Seventy five patients aged between 5 months–5 years diagnosed as rotavirus gastroenteritis were included in the study. The patients diagnosed as rotavirus gastroenteritis by latex agglutination test in stool were divided into 3 groups of twenty-five patients each: First group was given oral rehydration therapy and rapid refeeding with a normal diet withSaccharomyces boulardii(spp. I-745), second group was given oral rehydration therapy and rapid refeeding with a normal diet withBifidobacterium lactis(spp. B94, culture number:) and third group received only oral rehydration therapy and rapid refeeding with a normal diet.Results. The duration of diarrhea was shorter in the group given oral rehydration therapy and rapid refeeding with a normal diet withBifidobacterium lactisandSaccharomyces boulardiithan the group given only oral rehydration therapy and rapid refeeding with a normal diet.Conclusion.Bifidobacterium lactishas a complemental role in the treatment of rotavirus gatroenteritis and other probiotics may also have a beneficial effect in rotavirus gastroenteritis compared with the therapy included only oral rehydration therapy and rapid refeeding with a normal diet.
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28

O'BANION, LAURA. "Use and Misuse of Oral Therapy for Diarrhea." Pediatrics 88, no. 5 (November 1, 1991): 1073. http://dx.doi.org/10.1542/peds.88.5.1073.

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The article, "Use and Misuse of Oral Rehydration Therapy for Diarrhea," reveals a very low rate of pediatrician adherence to guidelines of the American Academy of Pediatrics and the World Health Organization for oral rehydration. I recently conducted a small study that may shed some light on one underlying factor. A telephone survey of 14 major pharmacies, including the outpatient pharmacies of two teaching hospitals with departments of pediatrics, revealed that not a single pharmacy carried any of the recommended oral rehydration solutions.
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29

Costa, Auxiliadora Damianne P. Vieira da, and Giselia Alves Pontes da Silva. "Oral rehydration therapy in emergency departments." Jornal de Pediatria 87, no. 2 (April 14, 2011): 175–79. http://dx.doi.org/10.2223/jped.2066.

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30

Bajkiewicz, Christopher T. "Drink of Life: Oral Rehydration Therapy." Journal of Christian Nursing 16, no. 4 (1999): 9–12. http://dx.doi.org/10.1097/00005217-199916040-00003.

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31

Varavithya, Wandee, Rujanee Sunthornkachit, and Boonchuay Eampokalap. "Oral Rehydration Therapy for Invasive Diarrhea." Clinical Infectious Diseases 13, Supplement_4 (March 1, 1991): S325—S331. http://dx.doi.org/10.1093/clinids/13.supplement_4.s325.

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32

Rhoads, Marc. "Oral Rehydration Therapy for Viral Enteritis." Journal of Pediatric Gastroenterology &amp Nutrition 22, no. 1 (January 1996): 114. http://dx.doi.org/10.1097/00005176-199601000-00020.

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33

SÖKÜCÜ, S., L. MARIN, H. GUNOZ, A. APERIA, O. NEYZI, and R. ZETTERSTROM. "Oral Rehydration Therapy in Infectious Diarrhoea." Acta Paediatrica 74, no. 4 (July 1985): 489–94. http://dx.doi.org/10.1111/j.1651-2227.1985.tb11015.x.

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34

Mack, D. R. "Oral Rehydration Therapy With a Twist." American Journal of Gastroenterology 93, no. 4 (April 1998): 502–3. http://dx.doi.org/10.1111/j.1572-0241.1998.501_5_5.x.

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35

Santosham, Mathuram, and William B. Greenough. "Oral rehydration therapy: A global perspective." Journal of Pediatrics 118, no. 4 (April 1991): S44—S51. http://dx.doi.org/10.1016/s0022-3476(05)81425-8.

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36

Gilboy, Nicki, and Paula Tanabe. "Oral Rehydration Therapy for Pediatric Gastroenteritis." Advanced Emergency Nursing Journal 29, no. 1 (January 2007): 3–9. http://dx.doi.org/10.1097/01261775-200701000-00002.

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37

Ahmad, Khabir. "Oral rehydration therapy improved for cholera." Lancet 355, no. 9203 (February 2000): 554. http://dx.doi.org/10.1016/s0140-6736(05)73203-7.

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38

Boo-Chai, Khoo. "Oral rehydration therapy in burn shock." Plastic and Reconstructive Surgery 90, no. 4 (October 1992): 735. http://dx.doi.org/10.1097/00006534-199210000-00062.

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39

Ebrahim, G. J. "Oral Rehydration Therapy in the 1990s." Journal of Tropical Pediatrics 35, no. 5 (October 1, 1989): 209–10. http://dx.doi.org/10.1093/tropej/35.5.209.

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40

EBRAHIM, G. J. "Oral Rehydration Therapy in the 1990s." Journal of Tropical Pediatrics 35, no. 5 (October 1, 1989): 211. http://dx.doi.org/10.1093/tropej/35.5.211.

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41

Rhoads, F. A. "Oral rehydration therapy for viral gastroenteritis." JAMA: The Journal of the American Medical Association 270, no. 5 (August 4, 1993): 578–79. http://dx.doi.org/10.1001/jama.270.5.578.

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42

Rhoads, Frances A. "Oral Rehydration Therapy for Viral Gastroenteritis." JAMA: The Journal of the American Medical Association 270, no. 5 (August 4, 1993): 578. http://dx.doi.org/10.1001/jama.1993.03510050044020.

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43

Glass, Roger I., and Barbara J. Stoll. "Oral Rehydration Therapy for Diarrheal Diseases." JAMA 320, no. 9 (September 4, 2018): 865. http://dx.doi.org/10.1001/jama.2018.10963.

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44

MACLEAN, WILLIAM C. "Rehydration." Pediatrics 77, no. 4 (April 1, 1986): 618. http://dx.doi.org/10.1542/peds.77.4.618a.

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To the Editor.— The recent well-done study by Santosham et al1 seems to be mistitled, "Oral Rehydration Therapy for Acute Diarrhea in Ambulatory Children in the United States. . ." Rehydration was not studied. The average gain in weight in the first 24 hours of fluid therapy was 1% or less and indicated that dehydration was generally absent. The investigators studied the situation as it exists in the United States, ie, well-nourished, generally well-hydrated children with diarrhea.
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45

LaPook, Jonathan, and Richard N. Fedorak. "Oral Rehydration Therapy: WHO at 40, ORT at 30." Canadian Journal of Gastroenterology 3, no. 1 (1989): 7–14. http://dx.doi.org/10.1155/1989/138105.

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Oral rehydration therapy may prove to be mankind's most significant therapeutic advance this century. Diarrheal disease remains the number one killer of children in the world and is a major cause of illness within Canada and other developed countries. Since its discovery 30 years ago, oral rehydration therapy, comprising glucose, salt and water, has been a simple and low cost treatment for people with life threatening diarrheal disease. Recent developments in solutions for oral rehydration therapy have led to the recognition chat the existing World Health Organization glucose based oral replacement salt could be improved. ln commercially available rehydration solutions, the sodium concentration has been lowered to reduce hypernatremia in noncholera induced diarrhea. Citrate has replaced bicarbonate as the base in oral replacement solutions to pro long shelf life. Organic substrates to replace glucose and enhance intestinal fluid and electrolyte absorption without osmotic penalty are being examined. However, their acceptance and proper utilization in developing countries remains to be determined.
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46

Bignyak, P. I. "Correction of electrolyte balance in surgical patients with urgent surgical interventions." Reports of Vinnytsia National Medical University 25, no. 4 (November 30, 2021): 620–22. http://dx.doi.org/10.31393/reports-vnmedical-2021-25(4)-19.

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Annotation. Acute appendicitis is one of the most common acute pathologies of the abdominal cavity, which requires immediate surgical intervention and can lead to water-electrolyte imbalance. The aim of the study was to investigate the clinical significance of electrolyte imbalance in patients operated on for acute appendicitis and their correction. We examined 20 urgent surgical patients who were part of the control group and received “traditional” postoperative therapy and 23 patients of the study group who received oral rehydration therapy in the postoperative period to correct water-electrolyte disorders. To analyze the results of the study, profile analysis was used as a modification of multidimensional covariance analysis with repeated measurements. As can be seen from the results of testing the hypothesis of normalization of homeostasis due to the use of oral rehydration therapy schemes, the hypothesis was confirmed with a threshold significance of p=0.0642. The only significant effect of the rate of normalization of potassium concentration in blood plasma is the appointment of oral rehydration therapy with p=0.045. Also, the appointment of oral rehydration therapy is a significant effect of the rate of normalization of sodium and glucose in plasma (normalization of plasma glucose is significantly better in the dynamics of younger patients (p=0.045)). Thus, normalization of potassium and glucose, which correlates with the patient's age, was better in patients receiving oral rehydration mixture in the postoperative period than in patients receiving “traditional” postoperative therapy. Oral rehydration therapy is an acceptable alternative to infusion therapy in patients undergoing surgery for acute appendicitis in the postoperative period.
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47

KENEFICK, ROBERT W., KATHLEEN M. O'MOORE, NICHOLAS V. MAHOOD, and JOHN W. CASTELLANI. "Rapid IV versus Oral Rehydration." Medicine & Science in Sports & Exercise 38, no. 12 (December 2006): 2125–31. http://dx.doi.org/10.1249/01.mss.0000235358.39555.80.

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48

Roberson, Lynne M., Amy J. McLaughlin, and Jill K. Lund. "Promoting oral rehydration therapy for acute diarrhea." Journal of the American Dietetic Association 87, no. 4 (April 1987): 496–97. http://dx.doi.org/10.1016/s0002-8223(21)03144-8.

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49

Gavin, Norma, Nancy Merrick, and Bruce Davidson. "Efficacy of Glucose-based Oral Rehydration Therapy." Pediatrics 98, no. 1 (July 1, 1996): 45–51. http://dx.doi.org/10.1542/peds.98.1.45.

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Objective. This article reviews and synthesizes evidence in the published literature on the safety and efficacy of oral rehydration therapy (ORT) among young children with pediatric gastroenteritis in developed nations. Methodology. We searched the literature for randomized, controlled trials comparing the safety and efficacy of ORT with intravenous (IV) rehydration treatment and/or oral rehydration solutions (ORSs) of different sodium content. We combined the failure rates of each set of studies in statistical meta-analyses and conducted tests of homogeneity of treatment effect over all the studies and for subgroups of children defined by the trial type, the sodium content of the ORS, and the setting of care. We also conducted a multivariate logistic regression on the probability of failure to determine the relative importance of these factors, controlling for other characteristics of the trials. Other outcomes were also tabulated and discussed. These include the relative incidence of hypernatremia and hyponatremia induced by treatment; weight gain; the volume, frequency, and duration of diarrhea; for inpatient trials, the length of stay; and for outpatient trials, rates of hospitalization. Results. The evidence suggests that among pediatric patients with gastroenteritis in developed countries, failure of ORT, defined as the need to rehydrate children intravenously, is infrequent. We found a combined overall ORT failure rate of 3.6%. We found no statistically significant difference in failure rates by trial type or the sodium content of the ORS. However, we did find some supporting evidence for a lower failure rate among children treated in outpatient settings. In addition, compared with patients rehydrated intravenously, pediatric patients treated with ORT were not found to be at higher risk of iatrogenic hypernatremia or hyponatremia. The evidence from the literature fails to show a consistent trend in favor of either high-or low-sodium solutions for rehydration of pediatric patients. Conclusions. There seems to be a great potential for improving the medical treatment of children with acute gastroenteritis by the greater use of ORT.
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50

Reis, Evelyn Cohen, Julius G. Goepp, Scott Katz, and Mathuram Santosham. "Barriers To Use of Oral Rehydration Therapy." Pediatrics 93, no. 5 (May 1, 1994): 708–11. http://dx.doi.org/10.1542/peds.93.5.708.

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Objective. To identify potential barriers to the use of oral rehydration therapy (ORT) by pediatric practitioners. Design. Cross-sectional, anonymous, self-administered survey of physicians' ORT knowledge, attitudes, and practice. Setting. A national continuing medical education conference. Participants. One hundred four general pediatricians primarily in private practice (66%) who completed training after 1980 (76%). Measurements and results. Most respondents (83%) reported that ORT plays an important role in their management of dehydration. However, compliance with guidelines from the American Academy of Pediatrics for use of oral therapy is limited: 30% withhold ORT in children with vomiting or moderate dehydration, 50% fail to advise prompt refeeding, and only 3% advise use of a spoon or syringe. The degree of importance of ORT in physicians' practice was negatively associated with reported lack of convenience of ORT administration in the practice setting (P < .001), support staff preference for intravenous versus ORT (P < .001), need for additional training of support staff to implement ORT (P < .01), and likelihood of reimbursement for intravenous versus ORT (P = .07). Notably, degree of importance of ORT was not associated with physician ORT knowledge. Conclusion. Efforts to improve use of ORT should be expanded beyond physician education and focus on such barriers as support staff limitations and financial constraints.
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