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Journal articles on the topic 'Oral submucous fibrosis (OSF); precancerous disorder'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Shih, Yin-Hwa, Tong-Hong Wang, Tzong-Ming Shieh, and Yu-Hsin Tseng. "Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy." International Journal of Molecular Sciences 20, no. 12 (2019): 2940. http://dx.doi.org/10.3390/ijms20122940.

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Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5–15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also impo
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Soham, Kulkarni Sachin Jadhav Sahil Shaikh* Suraj Gholap. "A Review on Screening Model for Submucosa Fibrosis." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3445–56. https://doi.org/10.5281/zenodo.15475252.

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Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5–15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Oral submu
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3

You, Jie-Ru, Ya-Ting Chen, Chia-Yu Hsieh, et al. "Exploring Possible Diagnostic Precancerous Biomarkers for Oral Submucous Fibrosis: A Narrative Review." Cancers 15, no. 19 (2023): 4812. http://dx.doi.org/10.3390/cancers15194812.

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Oral submucous fibrosis (OSF) stands as a progressive oral ailment, designated as a potentially malignant disorder. OSF has gained widespread recognition as a significant precursor to malignant transformation. In the pursuit of dependable, straightforward, and non-invasive diagnostic measures for the early detection of oral malignant progression, research has delved into potential diagnostic biomarkers of OSF. This comprehensive review delves into current investigations that explore the correlation between various biomarkers and OSF. The molecular biomarkers of OSF are categorized based on cyt
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Yu, Chuan-Hang, Chih-Yuan Fang, Cheng-Chia Yu, et al. "LINC00312/YBX1 Axis Regulates Myofibroblast Activities in Oral Submucous Fibrosis." International Journal of Molecular Sciences 21, no. 8 (2020): 2979. http://dx.doi.org/10.3390/ijms21082979.

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Oral submucous fibrosis (OSF) has been recognized as a precancerous disorder in the oral cavity. Great effort has been made to inhibit the malignant progression of OSF over the past decades, but the cure of this fibrosis disease has not been discovered. In the present study, we found that a long noncoding RNA, LINC00312, was upregulated in OSF tissues, and positively associated with several fibrosis factors, such as α-SMA, type I collagen, and fibronectin. As such, we sought to investigate the role of LINC00312 in OSF progression and identify its interacting factor that mediated oral fibrogene
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Yu, Cheng-Chia, Yi-Wen Liao, Pei-Ling Hsieh, and Yu-Chao Chang. "Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis." International Journal of Molecular Sciences 22, no. 4 (2021): 2216. http://dx.doi.org/10.3390/ijms22042216.

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Oral submucous fibrosis (OSF) is known as a potentially malignant disorder, which may result from chemical irritation due to areca nuts (such as arecoline). Emerging evidence suggests that fibrogenesis and carcinogenesis are regulated by the interaction of long noncoding RNAs (lncRNAs) and microRNAs. Among these regulators, profibrotic lncRNA H19 has been found to be overexpressed in several fibrosis diseases. Here, we examined the expression of H19 in OSF specimens and its functional role in fibrotic buccal mucosal fibroblasts (fBMFs). Our results indicate that the aberrantly overexpressed H1
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Peng, Chih-Yu, Yi-Wen Liao, Ming-Yi Lu, Chieh-Mei Yang, Pei-Ling Hsieh, and Cheng-Chia Yu. "Positive Feedback Loop of SNAIL-IL-6 Mediates Myofibroblastic Differentiation Activity in Precancerous Oral Submucous Fibrosis." Cancers 12, no. 6 (2020): 1611. http://dx.doi.org/10.3390/cancers12061611.

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Oral submucosal fibrosis (OSF) is a premalignant disorder of the oral cavity, and areca nut chewing is known to be a major etiological factor that could induce epithelial to mesenchymal transition (EMT) and activate buccal mucosal fibroblasts (BMFs). However, this detailed mechanism is not fully understood. In this study, we showed that the upregulation of Snail in OSF samples and fibrotic BMFs (fBMFs) may result from constant irritation by arecoline, a major alkaloid of the areca nut. The elevation of Snail triggered myofibroblast transdifferentiation and was crucial to the persistent activat
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7

Parikh, Pratyush. "A short review: Oral Submucous Fibrosis (OSMF)." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 82–84. https://doi.org/10.35629/4494-10028284.

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Oral submucous fibrosis (OSF) is a chronic condition characterized by abnormal collagen deposition in the oral submucosa, resulting in tissue scarring, dysphagia, and trismus. OSF is considered precancerous, with a transformation rate to malignancy ranging from 1.5% to 15%. This condition significantly impacts quality of life due to symptoms such as ulceration, xerostomia, and a burning sensation. This review provides a comprehensive analysis of OSF, focusing on its molecular mechanisms, diagnostic biomarkers, and therapeutic strategies. Betel nut chewing is a major risk factor, particularly p
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8

Nayak, Meghanand T., Anjali Singh, Rajiv S. Desai, and S. S. Vanaki. "Immunohistochemical Analysis of Vimentin in Oral Submucous Fibrosis." Journal of Cancer Epidemiology 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/549041.

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Background. Oral submucous fibrosis (OSF), a precancerous condition, is characterized by abnormal accumulation of collagen fibers in oral submucosa. Vimentin is a Class 2 intermediate filament (IF) and primarily expressed in cells of mesenchymal origin. Vimentin is also found to be involved in cell growth, cell cycling, and tumour differentiation.Objective. The purpose of the study was to compare the expression of vimentin in various histological grades of OSF.Materials and Methods. To assess the immunohistochemical expression of vimentin in 20 mild cases of OSF, 20 severe cases of OSF, and te
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9

Acharya, Siddharth, Sourab Kumar, Abhishek Jadhav, Priyadharshini, Faraz S., and Prince S. "Oral Submucous Fibrosis: A Case Report." International Journal of Current Research and Review 13, no. 05 (2021): 152–54. http://dx.doi.org/10.31782/ijcrr.2021.sp285.

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Introduction: Oral submucous fibrosis (OSF) is an insidious chronic disease affecting the mucosa of any part of the oral cavity and occasionally extending into the pharynx and esophagus. It occurs at any age but is most commonly seen in young adults between 25 and 35 years (2nd–4th decade). Characteristic male preponderance is reported in the literature with strong association with the chewing of smokeless tobacco. Aims: To find a provisional diagnosis of oral submucous fibrosis. Case Report: The present case report describes a case of OSF in a 40-year-old male patient. Discussion: The frequen
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Bhattacharjee, Tathagata, Supratim Ghosh, Dipto De, Pratik Sarkar, and Jay Gopal Ray. "Comparative analysis of blood vessel morphometry in advanced oral submucous fibrosis and malignancy associated with oral submucous fibrosis." Journal of Oral and Maxillofacial Pathology 29, no. 1 (2025): 12–17. https://doi.org/10.4103/jomfp.jomfp_89_24.

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Abstract Introduction: Oral submucous fibrosis (OSF) is a potentially malignant disorder of oral cavity. The vascularity of submucosa in this disease can predict its malignant transformation. Aim: In this study, attempts have been made to investigate different parameters of vascularity, such as mean vascular area, luminal diameter etc., in advanced OSF and make a comparison with malignancy associated with OSF. Materials and Methods: Incisional biopsy was taken from clinically diagnosed cases of advanced OSF and malignancy associated with OSF. Sections were prepared and stained with haematoxyli
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11

Li, J., M. Yao, X. Zhu, et al. "YAP-Induced Endothelial-Mesenchymal Transition in Oral Submucous Fibrosis." Journal of Dental Research 98, no. 8 (2019): 920–29. http://dx.doi.org/10.1177/0022034519851804.

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Oral submucous fibrosis (OSF) is a potentially malignant disorder. Current studies have shown that chewing areca nut is considered the main cause of OSF, and endothelial-mesenchymal transformation (EndMT) participates in the occurrence and development of the fibrotic lesion. However, the specific molecular mechanisms and treatments remain unclear. Here, we report the mechanism of arecoline-induced EndMT and the importance of this mechanism in OSF, and we also identify potential therapeutics for decreasing OSF incidence. We demonstrate the overexpression of Yes-associated protein (YAP) in human
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Xu, Chunjiao, Jing Zhao, Wings T. Y. Loo, et al. "Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis." International Journal of Biological Markers 27, no. 4 (2012): 314–21. http://dx.doi.org/10.5301/jbm.2012.9937.

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Background DNA methylation of certain genes is an epigenetic change that is essential for tumorigenesis. Oral submucous fibrosis (OSF) is a precancerous condition of oral mucosa with inflammation and progressive fibrosis of the lamina propria and deeper connective tissue. The hypermethylation of E-cadherin and cyclooxygenase 2 (COX-2) in chronic inflammation may demonstrate a mild lesion/mutation at epigenetic levels. This study compares the hypermethylation status of E-cadherin and COX-2 genes in patients with oral cancer and patients with OSF and also aims to identify risk factors for the de
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Qin, Xiaofeng, Yujie Ning, Liming Zhou, and Youming Zhu. "Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets." International Journal of Molecular Sciences 24, no. 5 (2023): 4992. http://dx.doi.org/10.3390/ijms24054992.

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Oral submucosal fibrosis (OSF) is a chronic, progressive and potentially malignant oral disorder with a high regional incidence and malignant rate. With the development of the disease, the normal oral function and social life of patients are seriously affected. This review mainly introduces the various pathogenic factors and mechanisms of OSF, the mechanism of malignant transformation into oral squamous cell carcinoma (OSCC), and the existing treatment methods and new therapeutic targets and drugs. This paper summarizes the key molecules in the pathogenic and malignant mechanism of OSF, the mi
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Bag, Swarnendu, Debabrata Dutta, Amrita Chaudhary та ін. "Identification of α-enolase as a prognostic and diagnostic precancer biomarker in oral submucous fibrosis". Journal of Clinical Pathology 71, № 3 (2017): 228–38. http://dx.doi.org/10.1136/jclinpath-2017-204430.

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AimsDiagnostic ambiguities regarding the malignant potentiality of oral submucous fibrosis (OSF), an oral precancerous condition having dysplastic and non-dysplastic isoforms are the major failure for early intervention of oral squamous cell carcinoma (OSCC) patients. Our goal is to identify proteomic signatures from biopsies that can be used as precancer diagnostic marker for patient suffering from OSF.MethodsThe high throughput techniques adopting de novo peptide sequencing (1D SDS-PAGE coupled nanoLC MALDI tandem mass spectrometry (MS/MS)-based peptide mass fingerprint), immunohistochemistr
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Lin, Ching-Yeh, Pei-Ling Hsieh, Yi-Wen Liao, Chih-Yu Peng, Cheng-Chia Yu, and Ming-Yi Lu. "Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition." International Journal of Molecular Sciences 20, no. 6 (2019): 1328. http://dx.doi.org/10.3390/ijms20061328.

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Oral submucous fibrosis (OSF) is an oral precancerous condition associated with the habit of areca nut chewing and the TGF-β pathway. Currently, there is no curative treatment to completely heal OSF, and it is imperative to alleviate patients’ symptoms and prevent it from undergoing malignant transformation. Arctigenin, a lignan extracted from Arctium lappa, has been reported to have a variety of pharmacological activities, including anti-fibrosis. In the present study, we examined the effect of arctigenin on the cell proliferation of buccal mucosal fibroblasts (BMFs) and fibrotic BMFs (fBMFs)
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Liu, Ziyi, Wenwu Hu, Zhongyan Shan, Sixuan Liu, Zhigang Yao, and Hongzhi Quan. "Evaluation of stromal myofibroblasts in oral submucous fibrosis and its malignant transformation: An immunohistochemical study." Journal of Cancer Research and Therapeutics 20, no. 2 (2024): 706–11. http://dx.doi.org/10.4103/jcrt.jcrt_498_23.

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ABSTRACT Background: Oral submucous fibrosis (OSF) is a precancerous lesion, with oral squamous cell carcinoma (OSCC) being the most prevalent malignancy affecting the oral mucosa. The malignant transformation of OSF into OSCC is estimated to occur in 7–13% of cases. Myofibroblasts (MFs) play pivotal roles in both physiological and pathological processes, such as wound healing and tumorigenesis, respectively. This study aimed to explore the involvement of MFs in the progression of OSF and its malignant transformation. Materials and Methods: In total, 94 formalin-fixed paraffin-embedded tissue
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Shen, Yen-Wen, Yin-Hwa Shih, Lih-Jyh Fuh, and Tzong-Ming Shieh. "Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments." International Journal of Molecular Sciences 21, no. 19 (2020): 7231. http://dx.doi.org/10.3390/ijms21197231.

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Oral submucous fibrosis (OSF) is a collagen deposition disorder that affects a patient’s oral function and quality of life. It may also potentially transform into malignancy. This review summarizes the risk factors, pathogenic mechanisms, and treatments of OSF based on clinical and bio-molecular evidence. Betel nut chewing is a major risk factor that causes OSF in Asia. However, no direct evidence of arecoline-induced carcinogenesis has been found in animal models. Despite identification of numerous biomarkers of OSF lesions and conducting trials with different drug combinations, clinicians st
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18

Khatri, Musarrat J., Rajiv S. Desai, G. S. Mamatha, Meena Kulkarni, and Jay Khatri. "Immunohistochemical Expression of Mast Cells Using c-Kit in Various Grades of Oral Submucous Fibrosis." ISRN Pathology 2013 (August 29, 2013): 1–5. http://dx.doi.org/10.1155/2013/543976.

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Oral submucous fibrosis (OSF) is a high risk precancerous condition characterized by changes in the connective tissue fibers of lamina propria and deeper parts of mucosa. Mast cells are local residents of connective tissue and have been identified to participate in fibrotic process. These cells produce pharmacologically active substances necessary for the physiological function of our body in response to various stimuli as and when required and also play a significant role in the pathogenesis of oral diseases. Ten healthy volunteers and 30 clinically diagnosed OSF cases with histopathological
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Pandey, Ashish. "Novel Therapeutic Approaches for Oral Submucous Fibrosis." New Medical Innovations and Research 6, no. 2 (2025): 01–03. https://doi.org/10.31579/2767-7370/143.

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Oral Submucous Fibrosis (OSF) is a chronic, progressive, and potentially malignant disorder primarily associated with areca nut chewing. It results in fibrosis of the oral mucosa, leading to restricted mouth opening and a high risk of malignant transformation into oral squamous cell carcinoma. Conventional treatments, including steroids, antioxidants, and surgical interventions, have limited success in halting disease progression. This article explores novel therapeutic approaches such as molecular inhibitors, regenerative medicine, gene therapy, nanotechnology-based drug delivery, and immunom
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Lakshmi, Unnikrishnan, and Kumar Siddharth. "A Study of the Efficacy of Oral Colchicine in the Treatment of Oral Submucous Fibrosis." International Journal of Current Pharmaceutical Review and Research 15, no. 09 (2023): 104–9. https://doi.org/10.5281/zenodo.11649698.

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AbstractBackground & Objectives: Oral submucous fibrosis (OSF) is characterized by abnormal deposition of collagenand is considered to be a potentially malignant disorder by World Health Organization (WHO). It is aprecancerous disorder and transforms into malignancy in 1.5 – 15% of all cases. It manifests with wide varietyof symptoms like restriction in mouth opening, ulceration, xerostomia and burning sensation. Since it greatlyinterfere with the quality of life of the patients, proper treatment with primary focus on relieving the symptomsof OSF is necessary. The management of OSF h
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Zheng, Lian, Zhen-Jie Guan, Wen-Ting Pan, Tian-Feng Du, Yu-Jia Zhai, and Jia Guo. "Tanshinone Suppresses Arecoline-Induced Epithelial‐Mesenchymal Transition in Oral Submucous Fibrosis by Epigenetically Reactivating the p53 Pathway." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 26, no. 3 (2018): 483–94. http://dx.doi.org/10.3727/096504017x14941825760362.

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Oral submucous fibrosis (OSF) induced by chewing of the areca nut has been considered to be a precancerous lesion with a high probability of developing oral squamous cell carcinoma. Tanshinone (TSN) is the main component extracted from Salvia miltiorrhiza, a traditional Chinese medicine, which was found to have diverse pharmacological effects, such as anti-inflammatory and antitumor. In the current study, we aimed to identify the inhibitory effects and the underlying mechanism of TSN on OSF progress. We found that treatment with TSN inhibited the arecoline-mediated proliferation of primary hum
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Tan, Yisi, Yuting Huang, Linkai Guo, et al. "HLA-DQB1 Allele Polymorphism Associated with Oral Submucous Fibrosis in Hunan, China." Journal of Immunology Research 2024 (May 18, 2024): 1–7. http://dx.doi.org/10.1155/2024/8757860.

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Background and Objective. Oral submucous fibrosis (OSF) is a progressive and irreversible disorder of collagen metabolism, resulting in mucosal fibrosis, oral functional changes, and even malignant transformation. This study investigated the relationship between human leukocyte antigen (HLA)-DQB1 alleles and the susceptibility to OSF in a Hunan Han population, providing a new basis for clinical prevention and treatment of OSF. Methods. 44 OSF patients and 44 healthy volunteers were included in this study. To detect the expression frequency of HLA-DQB1 alleles in the two groups and analyze sign
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Jaganathan, Ranjit Kumar, Subramani Uma Maheswari, Devapriya Appukuttan, Dhayanand John Victor, P. S. G. Prakash, and Jasmine Crena. "Ultrasonographic Evaluation of Masseter Muscle in Patients with Oral Submucous Fibrosis." Journal of Interdisciplinary Dentistry 14, no. 3 (2024): 200–206. http://dx.doi.org/10.4103/jid.jid_58_24.

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Purpose: Oral submucous fibrosis (OSF) is a potentially malignant disorder associated with gutkha chewing habit, and India has the greatest number of people affected, worldwide. Constant chewing leads to untoward forces on the masticatory muscles, especially the masseter muscle (MM). Hence, with an interdisciplinary approach, diagnosis and cessation of the habit and treatment will improve the well-being of the patient. Aim: The aim of the study was to assess the changes in the structure and function of the MM in patients with OSF using B-mode and M-mode ultrasonography. Methodology: The study
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Mathew, D. G., and K. Ranganathan. "P1.109. Assessment of fibroblast subpopulations in oral submucous fibrosis (OSF) a precancerous condition." Oral Oncology Supplement 3, no. 1 (2009): 158. http://dx.doi.org/10.1016/j.oos.2009.06.395.

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Bansal, Shivani P., Treville Pereira, Rajiv S. Desai, Abinashi Jena та Vini Mehta. "Expression of transforming growth factor-β in oral submucous fibrosis: A systematic review". Journal of Oral and Maxillofacial Pathology 27, № 2 (2023): 348–58. http://dx.doi.org/10.4103/jomfp.jomfp_536_22.

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Oral submucous fibrosis (OSF) is a potentially malignant disorder characterised by inflammation and progressive fibrosis. Transforming growth factor-β (TGF-β) has been established as a master regulator of fibrosis in various organs; however, lack of systematic review on expression of TGF-β and its isoforms in OSF restrict the understanding of their behaviour in its pathogenesis. Online electronic databases, such as PubMed Medline, Cochrane Library, Embase, and Scopus, were searched from their respective dates of inception till 31st March 2022. Human studies related to TGF-β expression in histo
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Sachdev, Prageet K., Jeanne Freeland-Graves, S. Natasha Beretvas, and Namrata Sanjeevi. "Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis." International Journal of Dentistry 2018 (June 26, 2018): 1–14. http://dx.doi.org/10.1155/2018/3472087.

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Oral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa. Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent. The objective of this research is to perform a meta-analysis to summarize studies that report zinc (Zn), copper (Cu), and iron (Fe) in patients, with and without OSF. A literature search of Embase, PubMed, Cochrane Library, and Web of Science electronic databases was conducted for studies up to January 2017. A total of 34 reports met the inclus
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Chou, Ming-Yung, Pei-Ling Hsieh, Shih-Chi Chao, Yi-Wen Liao, Cheng-Chia Yu, and Chang-Yi Tsai. "MiR-424/TGIF2-Mediated Pro-Fibrogenic Responses in Oral Submucous Fibrosis." International Journal of Molecular Sciences 24, no. 6 (2023): 5811. http://dx.doi.org/10.3390/ijms24065811.

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Oral submucous fibrosis (OSF) has been recognized as a potentially malignant disorder and is characterized by inflammation and the deposition of collagen. Among various regulators of fibrogenesis, microRNAs (miR) have received great attention but the detailed mechanisms underlying the miR-mediated modulations remain largely unknown. Here, we showed that miR-424 was aberrantly overexpressed in OSF tissues, and then we assessed its functional role in the maintenance of myofibroblast characteristics. Our results demonstrated that the suppression of miR-424 markedly reduced various myofibroblast a
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Gupta, M., A. Pachauri, SK Singh, R. Ahuja, P. Singh, and SSS Mishra. "Recent Advancements in Oral Submucous Fibrosis Management: an Overview." Bangladesh Journal of Dental Research & Education 4, no. 2 (2014): 88–90. http://dx.doi.org/10.3329/bjdre.v4i2.20256.

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The management of Oral submucous fibrosis has been the subject of controversy ever since Schwartz first described the condition in 1952. It is potentially malignant disorder and crippling condition of oral mucosa. An attempt is made update the knowledge about the management of this precancerous condition with advancements which helps to reduce the mortality of oral cancer. DOI: http://dx.doi.org/10.3329/bjdre.v4i2.20256 Bangladesh Journal of Dental Research and Education Vol.4(2) 2014: 88-90
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Meshram, Mrunal. "Effect Of Local Application Of Aloe-Vera Gel In The Management Of Oral Submucous Fibrosis." DMIMS Journal of Dental Research 5, no. 4 (2021): 164–67. http://dx.doi.org/10.54054/jodr.2021545.

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Background : Oral sub mucous fibrosis (OSF) is a high risk precancerous condition, associated with areca nut and related products chewing habits. Aloe vera is a mannoprotein known to promote wound healing, and have anti-inflammatory, immunomodulatory, antioxidant properties. Anthraquinones present in the latex also have cytotoxic, radio-protective as well as and metastatic regulatory processes Aim: The present study was conducted to evaluate the degree of improvement in clinical signs and symptoms of the disease before and after treatment with Aloe-Vera gel. Objectives: 1.To evaluate degree mo
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Kazmi, Anum, Zia Abbas, Zohra Saleem, Safdar Haider, Waqas Ahmed Farooqui, and Shaheen Ahmed. "Relation of salivary MMP-8 with oral submucous fibrosis and oral squamous cell carcinoma: a cross sectional analytical study." BMJ Open 12, no. 12 (2022): e060738. http://dx.doi.org/10.1136/bmjopen-2021-060738.

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ObjectivesWe aim to evaluate salivary matrix metalloproteinases (MMP-8) levels in oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) for the purpose of diagnosis at the early stage via non-invasive method.SettingThe study was multicentre, carried out at a tertiary care hospital in Karachi, Pakistan.ParticipantsA total 60 participants of any age, sex and ethnicity were randomly selected for the purpose of this study. Patients demonstrating clinical evidence of OSF and biopsy-proven cases of OSCC were included. Patients with indeterminate histopathological report, immunodefici
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Han, Bin, Yanhui Zhang, Yuxia Xiao, Bohong Shi, Hong Wu, and Desheng Liu. "Adipose-Derived Stem Cell-Derived Extracellular Vesicles Inhibit the Fibrosis of Fibrotic Buccal Mucosal Fibroblasts via the MicroRNA-375/FOXF1 Axis." Stem Cells International 2021 (June 22, 2021): 1–15. http://dx.doi.org/10.1155/2021/9964159.

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Oral submucous fibrosis (OSF) is a precancerous lesion. Adipose-derived stem cell- (ADSC-) derived extracellular vesicles (EVs) (ADSC-EVs) regulate multiple oral diseases. Hence, this study explored the mechanism of ADSC-EVs in OSF. ADSCs were transduced with microRNA- (miR-) 375 mimic. ADSC-EVs and miR-375-overexpressed ADSC-EVs (EVs-miR-375) were extracted and identified. miR-375 expression in EVs and fibrotic buccal mucosal fibroblasts (fBMFs) was detected. EV uptake by fBMFs was observed. The targeted relationship between miR-375 and forkhead box protein F1 (FOXF1) was predicted and verifi
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Palliyal, S. "Assessment of Betel Quid Habits and Risk of Precancerous Oral Lesions Among Paniya Tribes of Wayanad, India - A Cross-Sectional Study." Journal of Global Oncology 4, Supplement 2 (2018): 12s. http://dx.doi.org/10.1200/jgo.18.16700.

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Background: Betel quid habits in India is widely prevalent and responsible for increased incidence of head and neck cancer in the country. Head and neck cancer is a major public health problem among Paniya tribes, a marginalized tribal group in Kerala state, India. Previous studies among Paniya tribals in Wayanad have documented a high prevalence of betel quid habit. Oral leukoplakia (OL) and oral submucous fibrosis (OSF) are the most common oral mucosal diseases that have a very high malignant transformation rate. Aim: Aim of this study was to evaluate the risks imposed by betel quid habits i
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Almuzaien, Mariam, Al Rayyan Mustafa, Dania Awais, et al. "Awareness of Oral Submucous Fibrosis among the Quid-Chewing South-Asian Expatriates in the United Arab Emirates." Journal of Pharmacy and Bioallied Sciences 16, Suppl 2 (2024): S1461—S1464. http://dx.doi.org/10.4103/jpbs.jpbs_966_23.

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ABSTRACT Oral submucous fibrosis (OSF) is a chronic disorder prevalent in South and Southeast Asia and is mainly related to the habit of chewing betel quid. Although there are numerous South-Asian studies about OSF, there is no study that evaluates the awareness of OSF among expatriate populations of South-Asian origin. Evaluated the awareness of OSF among South-Asian expatriate patients reporting to a dental hospital in Sharjah. Prevalidated questionnaires were given to 150 expatriate patients of South-Asian origin with quid-chewing habit reporting to the teaching clinics of a dental hospital
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34

Shetty, Subraj, Treville Pereira, Sandhya Tamgadge, Sandeep Kale, Pooja Kamat, and Sourab Kumar. "ENDOGLIN (CD105): A marker of tumour vasculature for assessment of malignant potential of oral submucous fibrosis." Journal of Oral and Maxillofacial Pathology 28, no. 4 (2024): 589–95. https://doi.org/10.4103/jomfp.jomfp_67_24.

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Abstract Background: Oral submucous fibrosis (OSMF) is a precancerous condition associated with the use of betel/areca nut in various forms. It is characterized by restricted mouth opening, tongue protrusion and cheek rigidity. Oral submucous fibrosis, is primarily prevalent among the people of the Indian subcontinent and it has been reported that about one third of the OSMF patients develop squamous cell carcinoma. Endoglin (CD-105) is a hypoxia induced protein and a potential marker for activated endothelial cells which signify tumorigenic neoangiogenesis. Aim: To determine expression of CD1
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35

Lee, Yu-Hsien, Yi-Wen Liao, Ming-Yi Lu, Pei-Ling Hsieh, and Cheng-Chia Yu. "LINC00084/miR-204/ZEB1 Axis Mediates Myofibroblastic Differentiation Activity in Fibrotic Buccal Mucosa Fibroblasts: Therapeutic Target for Oral Submucous Fibrosis." Journal of Personalized Medicine 11, no. 8 (2021): 707. http://dx.doi.org/10.3390/jpm11080707.

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Oral submucosal fibrosis (OSF) is a precancerous condition in the oral cavity and areca nut consumption has been regarded as one of the etiologic factors implicated in the development of OSF via persistent activation of buccal mucosal fibroblasts (BMFs). It has been previously reported that an epithelial to mesenchymal transition (EMT) factor, ZEB1, mediated the areca nut-associated myofibroblast transdifferentiation. In the current study, we aimed to elucidate how areca nut affected non-coding RNAs and the subsequent myofibroblast activation via ZEB1. We found that long non-coding RNA LINC000
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36

Haider, Rehan. "Anabolic Steroids." New Medical Innovations and Research 6, no. 2 (2025): 01–03. https://doi.org/10.31579/2767-7370/141.

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Oral Submucous Fibrosis (OSF) is a chronic, progressive, and potentially malignant disorder primarily associated with areca nut chewing. It results in fibrosis of the oral mucosa, leading to restricted mouth opening and a high risk of malignant transformation into oral squamous cell carcinoma. Conventional treatments, including steroids, antioxidants, and surgical interventions, have limited success in halting disease progression. This article explores novel therapeutic approaches such as molecular inhibitors, regenerative medicine, gene therapy, nanotechnology-based drug delivery, and immunom
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37

Holla, Vidya A., L. K. Chatra, Prashanth Shenai, Devika Shetty, and Ashwini Baliga. "A Study to Analyze Different Patterns of Quid Usage among Subjects with Oral Submucous Fibrosis in Mangalore Population." Advances in Medicine 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/6124059.

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Aim and Objectives. Oral submucous fibrosis (OSF) is a potentially malignant disorder associated with the usage of areca nut. Usage of processed forms of areca nut is popular among the youth and its carcinogenic effects are not well known. Due to large immigrant population, various patterns of areca nut usage are seen. The aim of this study is to assess the various quid chewing patterns and their association with severity of OSF.Materials and Methods. A cross-sectional study was carried out with 250 cases clinically and histologically diagnosed as having OSF lesion that were selected and subje
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38

Chiu, Hui-Fang, Chang-Shyue Yang, Hsien-I. Chi, et al. "Cyclooxygenase-2 expression in oral precancerous and cancerous conditions and its inhibition by caffeic acid phenyl ester-enriched propolis in human oral epidermal carcinoma KB cells." Archives of Biological Sciences 69, no. 1 (2017): 83–91. http://dx.doi.org/10.2298/abs160324081c.

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Oral cancer accounts for 3-5% of all cancers worldwide. The present study was undertaken to investigate the correlation between overexpression of cyclooxygenase-2 (COX-2) and various grades of oral cancer, and to ascertain the inhibitory effect of propolis in the human oral carcinoma cell line. For ex vivo studies, 45 patients with oral submucous fibrosis (OSF; n=15), oral leukoplakia (OLP; n=18) and oral squamous cell carcinoma (OSCC; n=18) were recruited, and a biopsy was done to determine COX-2 protein expression by Western blotting and immunohistochemistry (IHC). For the in vitro study, CO
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39

Elangovan, Elampavai, та Elanangai E. "Correlation of CD1a Positive Langerhans Cells and Transforming Growth Factor β in Oral Submucuous Fibrosis - An Immunohistochemical Study". International Journal of Clinical Oral and Maxillofacial Surgery 11, № 1 (2025): 40–52. https://doi.org/10.11648/j.ijcoms.20251101.15.

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Background: Impaired localized epithelial immune system leads to oral cancer. Langerhans Cells (LCs) act as regulators of immune response which are regulated by Transforming Growth Factor β. But their association in a potentially malignant disorder like Oral Submucous Fibrosis (OSF), has not been researched enough. The aim of this paper was to assess the relationship between TGF β and LCs in OSF and whether TGF β can be successfully used as a therapeutic target. Context: TGF β has been a known regulator of immune response through its action on LCs which is proven in some in –vitro studies and
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40

Lee, Yu-Hsien, Pei-Ling Hsieh, Shih-Chi Chao, Yi-Wen Liao, Chia-Ming Liu та Cheng-Chia Yu. "α-Mangostin Inhibits the Activation of Myofibroblasts via Downregulation of Linc-ROR-Mediated TGFB1/Smad Signaling". Nutrients 15, № 6 (2023): 1321. http://dx.doi.org/10.3390/nu15061321.

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Oral submucous fibrosis (OSF) is a premalignant disorder and persistent activation of myofibroblasts is implicated in this pathological progression. Increasing attention has been addressed towards non-coding RNA-regulated myofibroblasts activities and the effects of phytochemicals on non-coding RNA modulation are of great importance. In the present study, we examined the anti-fibrosis property of α-mangostin, a xanthone isolated from the pericarp of mangosteen. We found that α-mangostin exhibited inhibitory potency in myofibroblast activities and expression of fibrosis markers at the concentra
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41

Dr., Tayyab Tufail Dr. Mudasir Shah Dr. Haseeb Uddin. "A COMPREHENSIVE STUDY ON CORRELATION OF SMOKING AND SURVIVIN IN ORAL SUBMUCOUS CARCINOMA." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 1170–73. https://doi.org/10.5281/zenodo.2542090.

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<strong><em>Introduction: </em></strong><em>Oral sub mucous fibrosis (OSF) is a premalignant disorder associated with the chewing of areca nut. After transformation into squamous cell carcinoma (SCC), it is also responsible for mortality. The combination of areca nut and tobacco has led to a sharp increase in the frequency of OSF. </em><strong><em>Aims and objectives: </em></strong><em>The basic aim of the study is to find the correlation of smoking and survivin in oral sub mucous carcinoma in local population of Lahore.<strong> Material and methods: </strong>This study was conducted at Punjab
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42

Sarkar, Rupam. "Journey from Oral Sub mucous Fibrosis (Osmf) to Functional Disease-Free Mouth Opening." Journal of Health Physiotherapy and Orthopaedics 1, no. 1 (2024): 22–27. https://doi.org/10.55522/jhpo.v1i1.0008.

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Oral Submucous Fibrosis (OSMF) is a potentially malignant disease that causes oral mucosa damage. It is a well-known chronic insidious disease, precancerous condition, an autoimmune and collagen-related disorder with a multifactorial cause associated with betel quid chewing and characterized by gradual hyalinization of the lamina propria. In the large literature available for OSMF, multiple staging systems have already been proposed by various authors. Some of the most essential staging systems are widely utilized in clinical practice, resulting in earlier diagnosis and treatment. The treatmen
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43

Md. Asdullah, Nasir A. Salati, Masood H. Khan, R. K. Tiwari, Pradhuman Verma, and Anshul Aggarwal. "Comparative study of rebamipide & betamethasone in managing stomatopyrosis in oral submucous fibrosis (OSMF) patients." Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology 7, no. 3 (2021): 157–60. http://dx.doi.org/10.18231/j.jooo.2021.049.

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Oral sub mucous fibrosis (OSF) is commonly seen in the Indian subcontinent affecting individuals of all age groups. It is a potentially malignant disorder caused almost exclusively by the use of smokeless form of tobacco products. The malignant transformation rates vary from 3 to 19%. The standard of care (SOC) in managing OSF includes habit cessation, intralesional steroid and hyaluronidase injections, and mouth opening exercises. To evaluate the efficacy of rebamipide to reduce the oral burning sensation associated with OSMF as compared to coventional Betamethasone intralesional injection.Af
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Murthy, Vignesh, Petros Mylonas, Barbara Carey, et al. "Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis." Journal of Clinical Medicine 11, no. 7 (2022): 1793. http://dx.doi.org/10.3390/jcm11071793.

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Oral submucous fibrosis (OSF) is a chronic progressive condition affecting the oral cavity, oropharynx and upper third of the oesophagus. It is a potentially malignant disorder. The authors collated and analysed the existing literature to establish the overall malignant transformation rate (MTR). A retrospective analysis of medical and dental scientific literature using online indexed databases was conducted for the period 1956 to 2021. The quality of the enrolled studies was assessed by the Newcastle-Ottawa Scale (NOS). A meta-analysis using a random effects model of a single proportion was p
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45

Indra G, Maragathavalli G, and Deepika Rajendran. "Complete Blood Count as a Diagnostic Marker in Oral Lichen Planus." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (2020): 1766–71. http://dx.doi.org/10.26452/ijrps.v11ispl3.3510.

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Oral precancerous lesions and conditions like oral lichen planus, leukoplakia, or oral submucous fibrosis have the potential to develop into oral cancer. Oral cancer accounts for approximately 3 % of all malignancies. Oral lichen planus is a premalignant condition occurring in the oral cavity due to various factors. Blood investigations are routinely done minimally invasive procedures carried out for various diagnostic purposes. The study aims to identify if the complete blood count (CBC) can be used as a pathologic diagnostic marker in an oral premalignant disorder like oral lichen planus. A
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46

Madusanka, G. T., N. S. Piyarathne, D. A. Satharasinghe, and R. D. Jayasinghe. "Phenotypic species identification and ALS3 gene analysis in Oral <em>Candida albicans</em> isolates in patients with Oral Submucous Fibrosis &ndash; A Sri Lankan study." Ceylon Journal of Science 54, no. 3 (2025): 791–97. https://doi.org/10.4038/cjs.v54i3.8702.

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Oral Submucous Fibrosis (OSF) is an Oral Potentially Malignant Disorder, with a substantial risk of malignant transformation. The main risk factors are Areca nut, tobacco, alcohol, and betel quid. While Candida overgrowth is contributing factor, the prevalence of Candida spp. and its virulence genes is not well studied in the Sri Lankan population. The objective of this study was to identify the species level colonization of Candida and the presence of selected virulence genes in OSF patients. A crosssectional study was conducted with 24 OSF patients. Unstimulated whole saliva samples were col
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47

Aslam, Sidra, and Sarah Ghafoor. "Insulin-like growth factor-I signaling plays a pivotal role in the development of oral premalignant lesions in patients with diabetes mellitus." BioMedica 38, no. 3 (2022): 129–33. http://dx.doi.org/10.51441/biomedica/5-759.

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&lt;p&gt;Diabetes mellitus is a disorder of the metabolic system that is diagnosed by hyperglycemia and glucose intolerance. Diabetic patients are frequently prone to developing oral health complications, such as being at a higher risk for developing oral precancerous conditions like lichen planus, leukoplakia, and erythroplakia. Insulin-like growth factor-I (IGF-I) is a peptide hormone with a structure similar to insulin and belongs to the family of growth factors that play a vital role in the development of embryonic, postembryonic, and normal physiological functions of the human body. IGF-I
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48

Sevlani, Sonia T., Sheetal Gondkar, and Ravindranath Saudagar. "A REVIEW Oral Sub Mucous Fibrosis: A Review." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 712–15. http://dx.doi.org/10.22270/jddt.v9i3.2898.

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Oral Sub Mucous Fibrosis is a well- recognized clinical entity, known since the time of Sushruta. In the modern literature OSMF was first reported by Schwartz (1952), Joshi (1953) was the first person to describe this entity in India. Oral Sub Mucous Fibrosis (OSMF) is a potentially malignant disease that results in progressive juxtaepithelial fibrosis of the oral soft tissues, resulting in increasing loss of tissue mobility, marked rigidity and an eventual inability to open the mouth. The basic change is a fibroelastic transformation of the connective tissue in the lamina propria followed by
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49

Athukorala, Isuru, R. M. S. H. B. Medawela, Malika Gunawardana, and R. D. Jayasinghe. "GIS to Explore the Geographical Mysteries of Oral Cancer: Geospatial Distribution of Patients Diagnosed with Oral Potentially Malignant Disorders at the University Dental Hospital Peradeniya." Asian Pacific Journal of Cancer Care 7, no. 1 (2022): 29–35. http://dx.doi.org/10.31557/apjcc.2022.7.1.29-35.

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Background: Oral cancers which are often preceded by an oral potentially malignant disorder (OPMD) carries the highest mortality rate among all cancers in Sri Lanka. Dental Teaching Hospital, Peradeniya is one of the tertiary centres in Sri Lanka for treating OPMD with a high patient turnover. Objectives: This study aimed to determine the geospatial distribution of OPMD patients who attended Dental Hospital, Peradeniya (DHP) using geocoding methods. Materials and Methods: A retrospective study was done by obtaining data of 869 OPMD patients who visited DHP within the last 4 years to geo-code t
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50

Misbahul, Haque. "Pre- and Post-Treatment Comparison of Intralesional Dexamethasone and Hyaluronidase for Managing Oral Submucous Fibrosis (OSMF)." International Journal of Pharmaceutical and Clinical Research 16, no. 11 (2024): 2002–6. https://doi.org/10.5281/zenodo.14637495.

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<strong>Background:</strong>&nbsp;(OSMF) is a chronic, progressive disorder of the oral mucosa, characterized by fibrosis of the submucosal tissues, leading to restricted mouth opening, pain, and difficulty in oral functions. The condition is considered a precancerous lesion with a significant risk of malignant transformation, particularly in regions with high betel nut chewing prevalence. Despite its high prevalence, the management of OSMF remains challenging, with limited success from conservative therapies.&nbsp;<strong>Aim:</strong>&nbsp;This study aimed to evaluate the efficacy of intrale
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