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Shahid, Hassan, Munaza Qadri, and Sadia Hassan. "ORAL SUBMUCOUS FIBROSIS;." Professional Medical Journal 24, no. 11 (November 3, 2017): 1719–26. http://dx.doi.org/10.29309/tpmj/2017.24.11.657.
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Objectives: To assess the impacts of oral sub mucous fibrosis (OSMF) on patientsthrough Oral Health Impact Profile, its correlation with clinical grading, and influence of OHIP-14on the patients willingness to quit habit. Study Design: A Cross sectional, Hospital based study.Setting: Isra university Hospital, Hyderabad. Period: Six months. Materials and Methods: Asample of 48 subjects was selected non-probability purposive sampling according to inclusionand exclusion criteria. Data was collected on a proforma. Informed consent was taken fromparticipants. Clinical diagnosis of OSMF was based upon clinical symptoms. Results: Malepopulation predominated over female. Oral health of OSF patients as evaluated in presentstudy, revealed overall bad oral health of study subjects. One or the other complaints of OHIP-14 were present in patients and they complained mainly about difficulties in word pronunciation,bad taste, mouth ache, uncomfortable eating, psychological discomfort etc. Pindborg stagingshows most patients fall in stage II 27 (56.2%), followed by stage I and II as 13 (27.0%) and8 (16.6%) respectively. Conclusion: Over all very bad oral hygiene was observed in most ofstudy population as determined by oral health impact profile-14 questionnaire in patients oforal submucosal fibrosis. OHIP-14 showed positive correlation with Pindborg clinical grading.OHIP-14 may help in improving oral hygiene of disease population in our community.
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Galinde, Jyotsna, and Ashvin Panditrao Wagh. "Oral Submucous Fibrosis." Journal of Contemporary Dentistry 6, no. 1 (2016): 67–69. http://dx.doi.org/10.5005/jp-journals-10031-1144.
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ABSTRACT The pedicled buccal pad of fat has been widely used for the reconstruction of defect; application of this flap in the treatment of patient suffering from oral submucous fibrosis (OSMF) is reported here. The patient underwent incision of fibrotic bands and coverage of this buccal defect with buccal pad of fat. The surgical technique is described and the results suggest that this is a logical, reliable, and convenient technique for OSMF. How to cite this article Wagh AP, Galinde J. Oral Submucous Fibrosis. J Contemp Dent 2016;6(1):67-69.
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Hande, Alka, Archana Sonone, Madhuri Gawande, Swati Patil, Aayushi Pakhale, and Shelley Durge. "Histomorphometric analysis of angiogenesis in oral submucous fibrosis and oral squamous cell carcinoma associated with oral submucous fibrosis." F1000Research 12 (September 1, 2023): 1082. http://dx.doi.org/10.12688/f1000research.134764.1.
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Background: Oral submucous fibrosis (OSMF), now worldwide acknowledged as the disease of “Southeast Asia and Indian subcontinent”, has the utmost malignant transformation prevalence amongst oral precancerous disorders. Increased vascularity that is neoangiogenesis has been observed in the superficial connective tissue region of pre-cancerous lesions showing dysplasia. This could be an initial occurrence of the carcinogenesis process. The aim of this study will be to analyse neoangiogenesis by examining immunoexpression of CD105 in OSMF, and OSCC with OSMF cases. Methods: The project will comprise 30 normal oral mucosa samples (group I), 30 clinicopathologically diagnosed cases of OSMF (group II), and on the basis of association of OSMF, 30 surgically operated and histopathologically diagnosed cases of OSCC associated with OSMF (group III). Hematoxylin and eosin stains will be used for routine staining procedures and immunohistochemistry for the expression of CD105. Oral epithelial dysplasia (OED) cases of OSMF will be categorized into two groups, low-risk epithelial dysplasia (LRED) and high-risk epithelial dysplasia (HRED). The micro vessel density (MVD), total microvessel area (TVA), and mean microvessel area (MVA) are within and surrounding the tumor tissue sections immunostained with the CD105 antibody will be determined. ANOVA will be applied for evaluation of the mean scores of MVD, TVA, and MVA of groups II and III. The obtained score will be compared with different parameters of OSCC (TNM stage, lymph node metastasis, and histopathological grades). Conclusions: We postulate the progressively increased vascularity with the disease progression from LRED to HRED and further its transformation to invasive oral squamous cell carcinoma This increased vascularity will be evident by enhanced MVD, TVA and mean MVA, which is expressed by CD105 immunoexpression. This observation will emphasize the significance of neoangiogenesis in cases of OSMF with epithelial dysplasia and its further progression to OSCC.
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Patel, Falguni, Shreyas N. Shah, and Christina James. "Oral Submucous Fibrosis - A Review." Journal of Evolution of Medical and Dental Sciences 10, no. 32 (August 9, 2021): 2665–71. http://dx.doi.org/10.14260/jemds/2021/544.
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A common oral disease named as oral submucous fibrosis (OSMF) has the tendency to usually affect many areas of the oral cavity as well as involving the area of pharynx. The characteristic feature of oral submucous fibrosis is the fibrosis in submucosal area which involves maximum part of oral cavity leading to advanced lock jaw as a result of rigidity in cheeks, pharynx, lips and upper third part of the oesophageal canal progressing to dysphagia. It has been reported that OSMF occurs mainly in persons who are habituated to chew areca nut or products containing areca nut along with other ingredients. In recent years with the introduction of commercially available Gutka and other areca nut products, the incidence of OSMF is increasing especially in the younger generations. OSMF is irreversible and persists even after cessation of chewing habit and the severity increases along with the duration of habit. In 2007, the categorization of oral submucous fibrosis was done as a premalignant condition by WHO and it has higher chances of malignant transformation. Early diagnosis and application of proper treatment modality is mandatory to reduce morbidity and mortality rate. There are many classification systems that have been proposed in literature for oral submucous fibrosis, among which many are based on clinical features, some of them on functional aspects and others are based on histopathological aspects. Here is an attempt to enlighten the facts and recent updates of clinical, functional, histopathological features as well as pathogenesis and management of oral submucous fibrosis. The complete knowledge of oral submucous fibrosis is a useful to the clinicians as well as academicians and researchers for timely detection and proper management of the disease. KEY WORDS Oral Submucous Fibrosis, Precancerous Lesions, Precancerous Conditions, Sclerosing Stomatitis
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Narang, Ramandeep S. "Oral Submucous Fibrosis: An Overview." AMEI's Current Trends in Diagnosis & Treatment 1, no. 1 (March 1, 2017): 22–26. http://dx.doi.org/10.5005/jp-journals-10055-0005.
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ABSTRACT Oral submucous fibrosis (OSMF) is a chronic and potentially malignant condition of the oral cavity. It occurs predominantly in India and Southeast Asia. The pathogenesis of OSMF is not well established, but it is believed to be multifactorial. Chewing of betel quid (containing areca nut, tobacco, and slaked lime) has been recognized as one of the most important risk factors. It is characterized by a juxtaepithelial inflammatory reaction followed by fibroelastic changes in the lamina propria and associated epithelial atrophy. The disease affects most parts of the oral cavity as well as the upper third of the esophagus. The abnormal fibrosis causes blanching and stiffness of the mouth, with eventual immobility of the lips, cheeks, tongue, soft palate, and uvula. Treatment of OSMF is difficult; a combination drug treatment is administered. In patients with severe disease, physical therapy and/or surgery is added to drug therapy. How to cite this article Narang RS, Arora A. Oral Submucous Fibrosis: An Overview. Curr Trends Diagn Treat 2017;1(1):22-26.
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Karthik, Hegde, Preeti Nair, Harshkant P. Gharote, Kavita Agarwal, Guruprasad Ramamurthy Bhat, and Divyashree Kalyanpur Rajaram. "Role of Hemoglobin and Serum Iron in Oral Submucous Fibrosis: A Clinical Study." Scientific World Journal 2012 (2012): 1–5. http://dx.doi.org/10.1100/2012/254013.
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Background. Oral submucous fibrosis is a chronic, insidious oral mucosal condition affecting the most parts of the oral cavity with high malignant transformation rate triggered by areca nut chewing, nutritional deficiencies, immunologic processes, and genetic predisposition. OSF causes significant hematological abnormalities resulting in anemia and a decrease in serum iron levels.Aim. The aim of this study was to estimate the hemoglobin and serum iron levels among patients with oral submucous fibrosis and to compare the values with healthy subjects.Materials and Methods. In this hospital-based study 30 diagnosed patients of OSMF and 15 healthy individuals were included, and the values of hemoglobin and serum iron levels were estimated using Sahli’s and Ferrene methods.Results. OSMF patients showed significantly lower levels of hemoglobin and serum iron when compared with the healthy subjects.Conclusion. The findings of the study emphasizes on the assessment of hemoglobin and serum iron for patients with oral submucous fibrosis. Also iron therapy should be instituted concomitantly with the initial diagnosis which helps to cease the further progression of the condition. Further extensive studies are indicated to understand the correlation between OSMF and iron deficiency.
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Iqbal, Waqas, Arhama Surwaich, Surwaich Ali Channa, Khalid Yousuf, Shahzaman Memon, and Shafquat Hussain Khuwaja. "Association of trace elements with oral submucous fibrosis." Professional Medical Journal 28, no. 08 (August 1, 2021): 1161–65. http://dx.doi.org/10.29309/tpmj/2021.28.08.6095.
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Objectives: Clinical assessment of OSMF patients visiting Isra dental college Hyderabad Sindh and correlation of trace elements in OSMF pathogenesis. Study Design: Observational Study. Setting: Outpatient Department, Oral Surgery Isra Dental College Hyderabad Sindh. Period: February 2016 January 2017. Material & Methods: Sixty research participants were categorized into control (group-II) and experimental group (group-I). Both clinical and physiological demographics of the research participants were recorded on a pre-designed questionnaire. In next phase, estimation of serum copper and serum zinc levels were determined for both control and OSMF patients by using spectrometric analysis. Patient data analysis was done by using Chi-square test and student’s t test. Where Microsoft office 2010 tools were also used for data presentation. Results: Based on clinical presentation 80 % patient were presenting with burning sensation in oral cavity in thirty OSMF patients. Where in control group only 3.3% patients were facing burning sensation in oral cavity. By assessing the functional staging of oral submucosa fibrosis about 50 % patients were presenting stage-II OSMF cytology. Where all the thirty participants in experimental group were presenting mucosal blanching. About 36 % patients suffering from OSMF were using Gutka and 33 % patients were using areca nut. Serum Zn mean value estimation in controls (Group II) and cases (Group I OSMF) was noted as 68.06 ± 17.10 and 94.20 ± 15.11 µg/dl respectively (t = 6.27, p=0.001). Conclusion: The present study concludes that increased serum trace element levels has significant correlation in the development and progression of OSMF.
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Sachdev, Sanpreet Singh, Yogita Bhaginath Adhane, Manisha Ahire Sardar, Tabita Joy Chettiankandy, and Sarang Gautam Sonawane. "Oral submucous fibrosis: Histopathological features with pathophysiologic correlations." IP Journal of Diagnostic Pathology and Oncology 6, no. 3 (September 15, 2021): 211–15. http://dx.doi.org/10.18231/j.jdpo.2021.045.
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Oral submucous fibrosis (OSMF) is a potentially malignant disorder characterized by juxtaepithelial inflammation and progressive fibrosis of submucosal tissues. It may affect any part of the oral cavity, as well as pharynx and oesophagus. The pathogenesis of OSMF may be attributable to habitual chewing of areca nut and its products, which is more prevalent amongst young population of South East Asia and India. Various histopathological features in different tissue components- epithelial, connective tissue stroma, muscle and salivary gland may be observed along the course of this chronic disorder. In connective tissue, extensive fibrosis with progressive hyalinization of collagen fibers and muscles accompanied by inflammatory response is considered to be pathognomonic feature. Advanced stages of OSMF may show atrophic changes or even dysplasia in the epithelium which may undergo malignant transformation. Malignant transformation rate of OSMF has been proved to be around 7.5%. Thus, identification of early histopathological changes in OSMF can lead to improved survival rates. The present article illustrates the various histopathological features observed during different stages of development of OSMF. A better understanding of the correlation between histopathological features and corresponding clinical manifestations can aid dental surgeons in prognostication of the lesion and determining response to treatment.
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Jamdade, Vaishali, and Amit LNU. "Nasolabial Flap in the Management of Oral Submucous Fibrosis." Journal of Mahatma Gandhi University of Medical Sciences and Technology 1, no. 1 (2016): 27–29. http://dx.doi.org/10.5005/jp-journals-10057-0007.
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ABSTRACT Oral submucous fibrosis (OSMF) is a premalignant condition associated with restricted mouth opening. Oral submucous fibrosis is poorly understood and unsatisfactorily treated disease. Serious complication is the risk of development of oral carcinoma. Different treatment modalities like medical, surgical, physical therapy or combination are used to improve the condition of the patient. Surgical treatment is usually indicated in late and irreversible stage of the disease. Successful use of nasolabial flap in the management of OSMF is presented. How to cite this article Jamdade V, Sharma S, Chitlangia P, Amit. Nasolabial Flap in the Management of Oral Submucous Fibrosis. J Mahatma Gandhi Univ Med Sci Tech 2016;1(1):27-29.
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Sathyanarayanan, Ramanujam, Nithin J. Jude, Thamizhp P. Guna, Rilna Pilavullathil, Raghu Kumaravel, C. Selvakumar, and S. Bharathi. "Management of Oral Submucous Fibrosis with Intralesional Injection of Hyaluronidase and Dexamethasone: A Case Report." Journal of Scientific Dentistry 10, no. 2 (2020): 41–42. http://dx.doi.org/10.5005/jp-journals-10083-0924.
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ABSTRACT Oral submucous fibrosis (OSMF) is a chronic premalignant condition more common. It occurs mostly due to betel quid chewing. The characteristic feature of OSMF is the progressive hyalinization of the submucosa. Resistance and progression are the factors that attributes to its nature of affecting the entire mucosa. It causes reduction in mouth opening gradually, which can extend to the pharynx. It is a potentially malignant condition causing fibrosis of the connective tissues. Although medical treatment provides only symptomatic, optimal doses of injection with corticosteroids, hyaluronidase, and local anesthesia locally produced significant reduction in the clinical symptoms. This article is to report a case of OSMF, which was treated similarly and had better results than either agents used individually. How to cite this article: Guna TP, Sathyanarayanan R, Pilavullathil R, Jude NJ, Raghu K, Selvakumar C, et al. Management of Oral Submucous Fibrosis with Intralesional Injection of Hyaluronidase and Dexamethasone: A Case Report. J Sci Dent 2020;10(2):41–42.
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Karthikeyan, Harippriya. "Insights from an awareness survey on oral submucous fibrosis (OSMF)." Bioinformation 16, no. 12 (December 31, 2020): 999–1006. http://dx.doi.org/10.6026/97320630016999.
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Oral Submucous Fibrosis (OSMF) is characterized by Juxta-epithelial inflammation with oedema, fibroblasts, neutrophil and eosinophil inflammatory infiltrate. Therefore, it is of interest to gain insights from an awareness survey on ORAL SUBMUCOUS FIBROSIS (OSMF). The sample size was 100 patients who had participated in this survey in Tamilnadu, India where 93% of the subjects used tobacco products. 81% of the patients were not aware of the malignancy caused by OSMF. A significant number of males use more tobacco than females (p value = 0.006 (<0.05) in the sample dataset. Thus, there is a need to create awareness on OSMF among the general population to combat the associated diseases.
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Karthikeyan, Harippriya. "Insights from an awareness survey on oral submucous fibrosis (OSMF)." Bioinformation 16, no. 12 (December 31, 2020): 999–1006. http://dx.doi.org/10.6026/97320630016999.
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Oral Submucous Fibrosis (OSMF) is characterized by Juxta-epithelial inflammation with oedema, fibroblasts, neutrophil and eosinophil inflammatory infiltrate. Therefore, it is of interest to gain insights from an awareness survey on ORAL SUBMUCOUS FIBROSIS (OSMF). The sample size was 100 patients who had participated in this survey in Tamilnadu, India where 93% of the subjects used tobacco products. 81% of the patients were not aware of the malignancy caused by OSMF. A significant number of males use more tobacco than females (p value = 0.006 (<0.05) in the sample dataset. Thus, there is a need to create awareness on OSMF among the general population to combat the associated diseases.
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Peng, Haiyan, Xiaowen Jiang, Linna Cui, Yali Zhu, Zhikui Ye, and Zhiming Zhang. "Mechanistic Investigation of Curcuma Protection against Oral Submucous Fibrosis." Evidence-Based Complementary and Alternative Medicine 2022 (August 9, 2022): 1–8. http://dx.doi.org/10.1155/2022/3891598.
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Objective. Oral submucous fibrosis (OSMF) is a chronic, fibrotic disease that affects the oral cavity, showing a high rate of malignant transformation. Curcuma exerts therapeutic potentials in many diseases including OSMF. However, the potential targets and pathways to explain the therapeutic effects of curcuma on OSMF are outside the scope of present knowledge. Herein we intend to reveal the predictive targets and potential pathways of curcuma against OSMF by a network pharmacology-based approach followed by molecular docking technology. Methods. We searched the SymMap, GeneCards, and OMIM database to obtain curcuma and OSMF common targets. The protein-protein interaction (PPI) of curcuma and OSMF common targets were then analyzed, followed by functional enrichment analysis. The best binding mode of curcuma and target proteins was analyzed by molecular docking technology. Results. We collected 290 putative targets of curcuma molecules and 600 known therapeutic targets of OSMF, with 64 curcuma and OSMF common targets sorted out. In the PPI network, there were 63 nodes with 922 edges. The node indicates protein and the line indicates PPI relation. The most enriched GO term in the BP level is “gland development”, followed by “cellular response to chemical stress”, and then “response to oxygen levels”, while the most enriched GO term in CC and MF is “membrane raft” and “cytokine receptor binding”, respectively. We also found 131 KEGG pathways significantly enriched by curcuma and OSMF common targets. The binding energy of curcuma to ALB, TNF, TP53, IL6, and VEGFA was −9.5 kcal/mol, −3.9 kcal/mol, −3.5 kcal/mol, −3.6 kcal/mol, and −8.9 kcal/mol, respectively, which suggested ALB and VEGFA were regarded as main targets involving in the potential mechanism of curcuma against OSMF. Conclusion. The present study illustrated that the therapeutic effects of curcuma on OSMF were achieved by targeting ALB and VEGFA, which giving reference to further drug design and development for OSMF.
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Bhalerao, Suwarna. "Salivary Analysis Of Iron In Oral Submucous Fibrosis: A Hospital Based Study." DMIMS Journal of Dental Research 5, no. 1 (January 1, 2021): 1–7. http://dx.doi.org/10.54054/jodr.2021511.
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Background: Oral sub mucous fibrosis is one of the potentially malignant conditions of the oral cavity. Iron is meticulously studied in recent years to judge whether they have any modifying effects in the etiology of precancer and cancer. Aim of study was to evaluate levels of iron in the saliva in patients with OSMF. Methods: Study group comprised of 66 patients, out of which 22 cases of clinically diagnosed OSMF patients and 22 cases of betel nut habitual without OSMF and 22 cases of age and sex matched control healthy patients were recruited. Estimation of Iron by Ferrozine method in Saliva was carried out by using Spectrophotometer. The statistical analysis was carried out. Results: Level of iron in saliva was significantly decreased in OSMF patients when compared to betel nut habitual and control group which were statistically significant. Conclusion: The present study, all the cases of OSMF revealed reduction in iron levels which suggests that iron plays an important role in the pathogenesis and progression of OSM. In group II (Betel nut habituals without OSMF) patients showed decrease in iron levels which suggest that, betel nut quid with or without tobacco consumption may alter the serum and salivary levels of iron and plays an important role in the advancement of OSMF. Therefore regular monitoring of betel nut habituals should also be carried out because they are at higher risk of developing OSMF. The present study indicates that saliva also may be used as a potential non-invasive diagnostic tool to evaluate the iron In OSMF patients. Keywords: PMDs , OSMF, Salivary biomarkers, Iron and Saliva.
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Sodha, Jinishaba. "Oral Submucous Fibrosis (OSMF)-A Case Report." Research Journal of Pharmacology and Pharmacodynamics 11, no. 3 (2019): 106. http://dx.doi.org/10.5958/2321-5836.2019.00019.3.
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Devathambi, Jones Raja, and Nalini Aswath. "Ultrasonographic Evaluation of Oral Submucous Fibrosis and Masseteric Hypertrophy." Journal of Clinical Imaging Science 3 (December 31, 2013): 12. http://dx.doi.org/10.4103/2156-7514.124057.
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Objectives: To evaluate the efficacy of ultrasonography (USG) as a non-invasive tool in assessing the severity of oral submucous fibrosis (OSMF) and also to assess the relationship between OSMF and hypertrophy of the masseter muscle. Materials and Methods: The submucosal thickness in buccal mucosa and masseteric muscle hypertrophy were measured using ultrasound (10-15 MHz) in 60 patients comprising 30 OSMF patients and 30 controls. Results: Results were analyzed by one way analysis of variance, Chi-square test and t-test. As the stages of OSMF advanced there was an increase in submucosal thickness of the buccal mucosa as well as masseter muscle thickness in both relaxed and contracted state in the study group when compared with controls (P < 0.005). Conclusion: USG is an effective non-invasive zero radiation tool for assessing the progression of OSMF.
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Swamy, K. Mallikarjuna, and Arati Ganiger. "Level of serum lactate dehydrogenase in oral submucous fibrosis." International Journal of Otorhinolaryngology and Head and Neck Surgery 2, no. 4 (September 26, 2016): 234. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20163472.
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<p class="abstract"><strong>Background:</strong> Oral cancer is one of the most common form of malignancies in India. In many cases it develops at the site of premalignant lesion. Of all oral premalignant conditions, oral submucous fibrosis (OSMF) is of greater concern because of its disabling nature and relative greater chances of malignant transformation. Transformation of normal tissue to premalignant lesion and further to oral cancer results in alteration in glycolytic pathway and hence the lactate dehydrogenase (LDH) levels. The aim of this study was to estimate the LDH levels in serum of subjects with OSMF and to compare them with healthy controls and to correlate the relationship between pathogenesis of OSMF and the LDH enzyme.</p><p class="abstract"><strong>Methods:</strong> It is a case control study. The study included 40 diagnosed cases of OSMF and 40 matched healthy controls. Venous blood of 3 ml was collected in both cases and controls. Serum was separated by centrifugation and LDH was estimated by using standard kits. Statistical analysis was done using student ‘t’ test. Pearson's correlation was performed to establish the relationship between study variables. </p><p class="abstract"><strong>Results:</strong> It was observed that serum LDH levels were significantly increased in cases of OSMF as compared to controls (p <0.005).</p><p><strong>Conclusions:</strong> Serum LDH was significantly increased in OSMF and can be used as a valuable biochemical marker in prognosis of OSMF.</p>
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Xu, Hui, Feng-yuan Lyu, Jiang-yuan Song, Yu-ming Xu, Er-hui Jiang, Zheng-Jun Shang, Li-li Chen, and Zhi Xu. "Research Achievements of Oral Submucous Fibrosis: Progress and Prospect." BioMed Research International 2021 (March 18, 2021): 1–10. http://dx.doi.org/10.1155/2021/6631856.
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Oral submucous fibrosis (OSMF) is a kind of chronic, insidious disease, and it is categorized into potentially malignant disorders (PMD), which poses a global and regional problem to public health. It is considered to be a multifactorial disease, such as due to areca nut chewing, trace element disorders, and genetic susceptibility. However, there is still no unanimous conclusion on its pathogenesis, diagnosis, and treatment strategies. Hence, this article provides a comprehensive review and prospect of OSMF research, providing scholars and clinicians with a better perspective and new ideas for the research and treatment of OSMF.
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Mohapatra, Diksha, Swagatika Panda, Neeta Mohanty, Saurav Panda, Natalia Lewkowicz, and Barbara Lapinska. "Comparison of Immunohistochemical Markers in Oral Submucous Fibrosis and Oral Submucous Fibrosis Transformed to Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis." International Journal of Molecular Sciences 24, no. 14 (July 21, 2023): 11771. http://dx.doi.org/10.3390/ijms241411771.
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The objective of the study was to compare the expression of immunohistochemical (IHC) markers of oral submucous fibrosis (OSMF) (non-transformed group) to those of oral squamous cell carcinoma (OSCC) transformed from OSMF (transformed group). The search for comparative cross-sectional studies was carried out in PubMed and Scopus abiding to the PICO criteria, where expression of IHC markers in OSMF were compared with that of OSCC transformed from OSMF. The cellular distribution, number of positive cases, staining intensity, and mean immunoreactive score (IRS) of each IHC marker were evaluated in both groups. A total of 14 studies were included in the systematic review, in which immunoexpression of 15 epithelial and 4 connective tissue biomarkers were evaluated. Expression of β1-integrin, OCT-3, CD1a, CD207, survivin, Dickkopf-1, COX-2, hTERT, CTGF, MDM2, Ki-67, and α-SMA were increased during transformation of OSMF to OSCC. Conversely, expression of PTEN and lysyl oxidase decreased during transformation of OSMF to OSCC. Expression of a group of epithelial markers, such as COX2, hTERT, CTGF, survivin, MDM2, and p53, was 38 times lower in the non-transformed group cases compared to transformed group cases (95% CI: 58% to 10%; p = 0.01; and I2 = 90%). Meta-analysis of all markers involved in cell metabolism/apoptosis, which included β1-integrin along with the above markers also suggested 42 times lower expression in the non-transformed group as compared to the transformed group (95% CI: 58% to 10%; p = 0.01; and I2 = 90%). Sub-group analyses on cytoplasmic and nuclear epithelial markers were inconclusive. Meta-analysis of connective tissue markers was also inconclusive. No publication bias was found. Instead of delving into numerous markers without a strong basis for their use, it is advisable to further study the markers identified in this study to explore their clinical utility.
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Pratap Singh Tamang, Gyan Prasad Bajgai, and Hari Prasad Pokhrel. "Distribution of Oral Submucous Fibrosis Cases and Malignant Transformation Rate among Bhutanese Patients Treated at Jigme Dorji Wangchuck National Referral Hospital, Bhutan." International Healthcare Research Journal 4, no. 12 (March 22, 2021): OR7—OR10. http://dx.doi.org/10.26440/ihrj/0412.03391.
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BACKGROUND: Oral Submucous Fibrosis (OSMF) is a chronic, insidious, scarring disease of the mouth often involving the palate, oro-pharynx, pharynx, esophagus, tongue and the buccal mucosa which leads to ulceration, blanching and ultimately limited mouth opening. The aim of the study is to describe the age, gender and district-wise distribution of oral submucous fibrosis cases and to assess the malignant transformation rate among the patients with oral submucous fibrosis who were treated at Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.MATERIALS AND METHOD: This is a descriptive retrospective study. The patients were clinically diagnosed by examining their mouth and by measuring their mouth opening (Inter-incisal height). Patients who had less than 3 fingers mouth opening and diagnosed as Oral submucous fibrosis (OSMF) during these three-year period from 2018 to 2020 were considered for the study.RESULTS: There were 278 cases in total. Thimphu district had the maximum number of cases followed by Wangduephodrang and Samtse. Gasa and Haa districts had the minimum cases. More males were affected than females. The malignant transformation rate among these patients was 4.3%.CONCLUSION: Thimphu district had the highest proportion of OSMF cases and was almost equally distributed among genders. Over 90% of the patients reported improvement without surgery while the malignancy transformation rate was 4.3%. The study recommends conducting screening in districts with high burden of OSMF cases for early diagnosis and treatment.
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Mallikarjuna Swamy, K., and Arati Ganiger. "Alterations of serum lipid profile in oral submucous fibrosis." International Journal of Otorhinolaryngology and Head and Neck Surgery 3, no. 4 (September 22, 2017): 1064. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20174334.
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<p class="abstract"><strong>Background:</strong> Oral cancer is one of the most common form of malignancies in India. In many cases it develops at the site of premalignant lesion. Of all oral premalignant conditions, oral submucous fibrosis (OSMF) is of greater concern because of its disabling nature and relative greater chances of malignant transformation. This study is aimed to evaluate the serum lipid profile in OSMF patients as the change in lipid levels may have a diagnostic and prognostic role in the potentially malignant lesions. The present study aimed to evaluate the alteration in serum lipid profile in OSMF and to compare them with healthy controls and to correlate the relationship between pathogenesis of OSMF and lipid profile.</p><p class="abstract"><strong>Methods:</strong> It is a case control study. The study included 50 diagnosed cases of OSMF and 50 matched healthy controls. Fasting venous blood of 3 ml was collected in both cases and controls and serum was separate. Fasting serum lipid profile including total cholesterol (TC), very low density lipoproteins (VLDL), low density lipoproteins (LDL), high density lipoproteins (HDL) and triglycerides (TG) were measured using automatic analyser. Statistical analysis was done using student 't' test .Pearson's correlation was performed to establish the relationship between study variables. </p><p class="abstract"><strong>Results:</strong> It was observed that there was statistically significant decrease in serum total cholesterol, TG, LDL, VLDL and HDL observed in patients with OSMF as compared to the control group (p<0.005).</p><p><strong>Conclusions:</strong> The low lipid levels associated with OSMF indicates that there is inverse relationship between oral cancer and serum lipid profile. Decrease in the lipid levels may be considered as a valuable biochemical marker in the early diagnosis and prognosis of oral malignancy. </p>
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Devgan, Dr Kamal, Dr Priyank Mistry, and Dr Tapan Nagpal. "A prospective study of evaluation of methods to decrease the morbidity in oral submucous fibrosis." International Journal of Advances in Scientific Research 1, no. 1 (February 28, 2015): 28. http://dx.doi.org/10.7439/ijasr.v1i1.1660.
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Aim: To evaluate the effect of antioxidants, intralesional steroids and laser in decreasing morbidity in patients of oral submucous fibrosisIntroduction: Oral submucous fibrosis (OSMF) is a chronic disorder characterized by progressive fibrosis of the lining mucosa of the upper digestive tract involving the oral cavity, oropharynx, and rarely the upper third of the esophagus, resulting in intolerance to spicy foods, burning sensation in the mouth, limitation of mouth opening and tongue mobility, xerostomia, dysphagia and hoarseness. OSMF has been reported to occur commonly in conjunction with premalignant diseases such as leukoplakia and lichen planus and therefore aprecursor to oral cavity cancer in many cases.Materials and Methods: This prospective study included 60 patients with OSMF attending the Ear Nose & Throat Clinic of Dhiraj Hospital, Piparia. Patients of OSMF were evaluated as per Performa and for proper treatment planning were broadly classified into 4 groups based on classification suggested by Sinha et al.Conclusion: Lycopene, an antioxidant has significant response in early cases of OSMF in decreasing the burning pain in oral cavity in OSMF. Inj. triamcinolone and Inj. hyaluronidase, given submucosally havesignificant response in early cases of OSMF to improve cheek flexibility.CO2 laser have significant results in achieving satisfactory mouth opening in OSMF but notcheek flexibility.
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LNU, Amit, Ashish Soni, and Prateek Agarwal. "The Use of Diode Laser in Treatment of Oral Submucous Fibrosis." Journal of Mahatma Gandhi University of Medical Sciences and Technology 1, no. 2 (2016): 79–81. http://dx.doi.org/10.5005/jp-journals-10057-0020.
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ABSTRACT Oral submucous fibrosis (OSMF) is an established precancerous condition with increased prevalence in the Indian subcontinent. The treatment of OSMF is a challenging task for a clinician. Different authors have suggested variety of treatment modalities and have claimed success rates; still there is no universally acceptable protocol for the management of OSMF. In our case, transaction of bands was done by contact diode lasers (12 watt) under local anesthesia and it offered good results. Diode lasers offered excellent results and had many advantages over conventional surgical treatment. How to cite this article Soni A, Sharma S, Chitlangia P, Amit, Agarwal P. The Use of Diode Laser in Treatment of Oral Submucous Fibrosis. J Mahatma Gandhi Univ Med Sci Tech 2016;1(2):79-81.
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Salvi, Rohini, Rohit Gadda, Varun Bhatia, Atul Patil, and Varsha Patel. "Oral Submucous Fibrosis – Review of Literature." Journal of Contemporary Dentistry 1, no. 1 (2011): 26–29. http://dx.doi.org/10.5005/jcd-1-1-26.
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Abstract Oral submucous fibrosis (OSMF) is a crippling disorder which is confined almost exclusively to the Indian subcontinent. The available epediomological data showed clear cut geographical and ethnic predisposition, which suggested that certain customs/ habits prevalent among the population groups in the south-east asia might be etiological factors. Despite its association with a significantly increased risk of cancer, the etiology is still not clear. More research is needed to elucidate the problem.
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Kamala, K. A., and S. Sankethguddad. "Potentiality of Malignant Transformation of Oral Submucous Fibrosis: A Prospective Study." Journal of Datta Meghe Institute of Medical Sciences University 18, no. 3 (2023): 376–81. http://dx.doi.org/10.4103/jdmimsu.jdmimsu_243_22.
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Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder (PMD) which has one of the highest rates of malignant transformation (MT) rate. The aim of this study was to assess the rate of MT of OSMF and to analyze the possible contributory factors such as age, gender, socioeconomic status, habits, various signs and symptoms, and presence of other oral PMDs in a group of OSMF patients attending the Oral Medicine Department. Materials and Methods: Out of 25,200 patients who visited the Outpatient Department of School of Dental Sciences, KIMSDU, Karad, from January 2017 to December 2020, 1342 (5.3%) were diagnosed with OSMF and comprised the study sample, in which 1300 (96.87%) were male and 42 (3.12) were female. All the patients were subjected to incisional biopsy, and clinical diagnosis was confirmed histopathologically. Results: The prevalence of OSMF was 5.3% with male predominance, and majority of OSMF patients were in the age group of 21–30 years. Betel chewer’s mucosa and leukoplakia was the most associated lesion. Out of total 1300 male and 42 female OSMF patients, 897 (69%) and 17 (40.47%) showed epithelial dysplasia, and 61 (4.69%) male and 1 (2.38%) female patients showed signs of MT, respectively. Conclusion: The present study highlights the importance of certain risk factors for OSMF that are associated with an increased chance of MT. There is an urgent need of awareness programs through public–private partnership.
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Narwal, Anjali, Mala Kamboj, Shruti Gupta, Esha Singh, and Pooja Sharma. "Exemplary Delineation of Osmf Turning Malicious." Dental Journal of Advance Studies 05, no. 02 (August 2017): 104–9. http://dx.doi.org/10.1055/s-0038-1672091.
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AbstractOral submucous fibrosis (OSMF) is a well-recognized, potentially malignant condition of the oral cavity that can affect any part of the oral mucosa. It is strongly associated with a risk of oral cancer, although the biology underlying this association is still unresolved. The purpose of this paper is to show the histopathological prototypical illustration of OSMF turning into oral squamous cell carcinoma.
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Garg, Vaitarni Vandana. "Oral Submucous Fibrosis-A Case Report." International Journal For Multidisciplinary Research 04, no. 04 (2022): 484–87. http://dx.doi.org/10.36948/ijfmr.2022.v04i04.054.
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Oral Submucous Fibrosis (OSMF) is a chronic, insidious, disabling disease of oral mucosa, oropharynx, and rarely, the larynx affecting millions of people worldwide with a prevalence rate of 0.4% in Indian rural population. It results in difficulty in the mouth opening and can be disabling to the patient. It needs a timely diagnosis and thus appropriate treatment can be administered depending on the degree of involvement. A case of Oral Submucous Fibrosis occurring in a 55 year old male patient is presented in this article.
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Boreak, Nezar. "Small Molecule “Silmitasertib” Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis." BioMed Research International 2021 (April 1, 2021): 1–8. http://dx.doi.org/10.1155/2021/6631848.
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Oral submucous fibrosis (OSMF) is considered a premalignant condition characterized by aggressive fibrosis of the submucosal tissues of the oral cavity reflecting its malignant transformation potential. Activation of transforming growth factor beta (TGF-β) signaling has been reported to lead increased collagen production and fibrosis. Recently, significant upregulation of TGF-β1 has been reported in OSMF as compared to normal tissues. Therefore, inhibition of the TGF-β1 may pave for the development of therapeutics of OSMF. Based on the structure-assisted drug designing, we found “silmitasertib” as potent inhibitor of TGF-β1. We suggest that this molecule can be validated and implemented for the treatment of OSMF.
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Balaji, Thodur M. Madapusi, Saranya Varadarajan, Debasish Bandyopadhyay, Raghunathan Jagannathan, Shankargouda Patil, and Thirumal Raj. "A potential protection of melatonin on pathogenesis of oral sub-mucous fibrosis (OSMF) : a current update." Melatonin Research 4, no. 1 (January 1, 2021): 84–98. http://dx.doi.org/10.32794/mr11250083.
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Oral submucous fibrosisis (OSMF) is a clinical condition of the oral cavity which is caused predominantly by areca nut consumption. This fibrotic condition affects almost all parts of the oral cavity and can cause significant reduction in mouth opening, thereby, resulting in functional impairment. The other potential risk of OSMF is its malignant transformation into oral squamous cell carcinoma, which occurs in a significant number of afflicted patients. Extensive researches have been conducted to understand the pathogenesis of OSMF for identification of tangible therapeutic modalities. To date, there is no effective therapeutic modality for this disorder. It is well known that melatonin has a potent anti-fibrotic, anti-oxidant, and pro-angiogenic effects. The therapeutic potential of melatonin on OSM cannot be ignored. In this article we have explored the potential mechanisms of melatonin as an adjuvant in the prevention and treatment of OSMF.
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Solanki, Varsha, Rajashree S. Unadkat, Charmi Mehta, Hetal P. Baraiya, and E. P. Bineesh. "An Ayurvedic Approach on Oral Submucous Fibrosis and its Management – A Review." Asian Pacific Journal of Health Sciences 9, no. 4 (June 20, 2022): 117–22. http://dx.doi.org/10.21276/apjhs.2022.9.4.24.
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Introduction: Oral submucous fibrosis (OSMF) is an insidious chronic disease characterized by a juxta epithelial inflammatory reaction, fibroelastic changes in the lamina propria, epithelial atrophy, trismus, and recurrent glossitis attacks. It is one of the most prevalent premalignant diseases in India. These days, OSMF is becoming more popular. A study on OSMF and its management according to the Ayurveda values more in the scientific field because Ayurveda’s main focus is on maintaining and promoting health care. Aim and Objectives: The aim of the study was to gain a better understanding of OSMF and its relationship to Sarvasara Mukharoga in Ayurveda. Materials and Methods: The contents of this article are based on modern medicine textbooks as well as Ayurvedic Samhitas. Clinical research published in both indexed and non-indexed journals was also consulted to obtain relevant content. Results: According to the Lakshanas described by Bruhatrayi, OSMF can be equated symptomatically with the Sarvasara Mukharoga. In the event of OSMF, the management of Sarvasara Mukharoga should be applied. Conclusion: On the basis of signs and symptoms, OSMF can be correlated with Sarvasara Mukharoga. Early treatment of OSMF using Ayurvedic medications and the cessation of habits helps in the easy cure of the disease.
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Mishra, Girish, Jaykumar Patel, and Yojana Sharma. "Surgical management of advanced oral submucous fibrosis: our experience." International Journal of Otorhinolaryngology and Head and Neck Surgery 5, no. 5 (August 27, 2019): 1291. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20193872.
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<p class="abstract"><strong>Background:</strong> Severe oral submucous fibrosis (OSMF) poses problem with maintenance of oral hygiene,detection of malignancies and maintenance of nutrition. Surgical treatment includes release of fibrous bands with or without reconstruction for the raw area and postoperative physiotherapy.</p><p class="abstract"><strong>Methods:</strong> All cases with OSMF who underwent surgical management at our institute were included in our study. The demographic data, preoperative interincisor distance, local examination was recorded. All patients underwent contrast enhanced computed tomography scan of head and neck to rule out hidden malignancy. All cases underwent OSMF band release with or without reconstruction. All patients were instructed for vigorous mouth opening exercise. All patients were followed upto 6 months and further divided into two groups depending upon whether they followed physiotherapy advice or not.</p><p class="abstract"><strong>Results:</strong> 13 patients of age group 18-47 years were included in our study. Male to female ratio was 1.6:1. Pre-operative mean interincisor distance was 7.5 mm whereas post-operative it was 19.5 mm. Patients who had followed mouth opening exercise were having a mean increase of 15 mm more as compared to those who did not.</p><p><strong>Conclusions:</strong> Even after surgical management of severe OSMF, mouth opening exercise remains the key factor for maintenance of mouth opening.</p>
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Rai, Arpita, Musarrat Siddiqui, Shama Parveen, Saba Parveen, Abdur Rasheed, and Sher Ali. "Molecular Pathogenesis of Oral Submucous Fibrosis: A Critical Appraisal." Biomedical and Pharmacology Journal 12, no. 04 (December 10, 2019): 2027–36. http://dx.doi.org/10.13005/bpj/1835.
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Oral submucous fibrosis (OSMF) is a chronic, potentially malignant condition of the oral mucosa and the habitual chewing of areca nut is believed to be the most potent etiological factor. The role of reactive oxygen species (ROS), epithelial-mesenchymal transition (EMT) and various cytokines and growth factors has been established in recent studies. The components of areca nut particularly, arecoline, flavonoids and copper have been found to affect fibroblasts, endothelial and epithelial cells through various biological pathways which are either down-regulated or up-regulated during different stages of the disease. However, the underlying molecular pathogenesis of OSMF is still partially understood.
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Kapgate, Tejashree Dashrath. "Effect of Turmeric on Serum Malondialdehyde levels in Oral Submucous Fibrosis." International Journal of Dentistry Research 5, no. 1 (May 17, 2020): 29–33. http://dx.doi.org/10.31254/dentistry.2020.5107.
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Background: Aspergillus flavous in betel nut secretes aflatoxin i.e. mycotoxin & tobacco which leads to production of free radicals and reactive oxygen species, thus increasing lipid peroxidation. Biological parameter of Lipid peroxidation is malondialdehyde. Hence present study was conducted to evaluate effect of turmeric on increased lipid peroxidation by using serum malondialdehyde levels & as a surrogate outcome on clinical signs & symptoms of oral submucous fibrosis (OSMF). Methods: In this study 270 subjects of which 30 were suffering from OSMF on turmeric with counseling them about stoppage of habit (group A), 30 subjects suffering from OSMF on turmeric without counseling them about stoppage of habit (group B), 30 subjects suffering from OSMF counseled for stoppage of habit but without turmeric medication (group C), 90 cases which were betel-nut habitual without OSMF (group D), 90 cases healthy control group (group E). Results: Statistically significant reduction in Serum MDA levels post treatment group A patients as compared to group B & group C (p<0.05). Mean difference was observed as 9.00 in group A, 3.81 in group B, 2.62 in group C. Conclusion: Increased serum MDA in OSMF can be used as an important marker in early diagnosis, treatment, prognosis and for prevention and clinical intervention of the disease. The antioxidant properties of turmeric reduce the oxidative stress even with effects of areca alkaloids. Serum MDA level was decreased in subjects taking turmeric medication for the period of 4 weeks
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Jain, Anuj, and Saumya Taneja. "Oral Submucous Fibrosis in Pediatric Patients: A Systematic Review and Protocol for Management." International Journal of Surgical Oncology 2019 (April 1, 2019): 1–6. http://dx.doi.org/10.1155/2019/3497136.
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Aim. To conduct a systematic review evaluating the cases of oral submucous fibrosis in pediatric patients. Material and Method. Systematic review was conducted using PRISMA guidelines. The article focused on oral submucous fibrosis in pediatric patients were included. A total of five manuscripts were included in our systematic review. The prevalence of OSMF in pediatric patients, gender distribution, causes, and clinical presentation were reviewed. Results. On systematically reviewing, a total of 10 cases of OSMF in pediatric patients were found. The youngest patient reported to be diagnosed with OSMF was of 2.5 years of age. Female preponderance was noticed. All the patients had the habit of areca nut chewing which subsequently led to fibrosis. Conclusion. Such a rapid increase in the rate of OSMF among pediatric population is a potential danger to the society. The habit of areca nut chewing is the major cause for this dreadful condition. Lack of health consciousness and low level of education are the major factors for initiation of this habit among children. Therefore it is imperative for the parents and school as well as government authorities to take serious actions.
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Shetty, Sameep S., Premalatha Shetty, and Amruta Ramgonda Chougule. "Facial Atrophy in Oral Submucous Fibrosis: An Association or a Coincidence." Case Reports in Dentistry 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/2080467.
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The anecdotal clinical presentation of OSMF that includes vesicle formation, burning sensation, intolerance to hot and spicy food, and trismus due to circumoral fibrous bands has been ringing in our ears for decades but the current paper flags novelty by portraying a rare presentation of an advanced stage of OSMF.
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Joshi, Jaya, Kundendu Arya Bishen, Sonam Gehi, Pratiksha Kumar, Anand Krishna Singh, and Puneet Gupta. "Association of Increased Red Cell Distribution Width with Malignant Transformation of Oral Submucous Fibrosis." Dental Journal of Advance Studies 07, no. 03 (December 2019): 123–27. http://dx.doi.org/10.1055/s-0040-1701146.
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Abstract Introduction Oral submucous fibrosis (OSMF) is associated with nutritional deficiencies—primarily of iron and vitamins and usually seem to be associated with anemia. Red cell distribution width (RDW) is one of the routinely assessed parameters in complete blood picture analysis of any patient. It measures range of variation in erythrocyte size. A high RDW value has been associated to adverse outcomes in several diseases and risk of death. However, the relationship of RDW and OSMF is yet to be established. Aim To analyze the association of RDW levels and other erythrocytic indices with clinical staging and prognosis of OSMF patients. Materials and Methods Analysis of clinical stage and hematologic status of 86 patients comprising the study group (OSMF cases and OSMF with malignant changes) and control group was performed. It was done using Kruskal–Wallis analysis of variance test. Results The values of mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were below normal from the onset of oral submucous fibrosis and they continued to decrease as the disease progressed. On other hand, RDW values were found to be in normal range in initial stages of disease and they became high in stage IV OSMF and increased further in OSMF patients with malignant changes. Conclusion We observed that higher values of RDW are strongly and independently associated with OSMF and OSCC, suggesting that RDW may contribute as most economic novel biochemical marker for progression and malignant transformation of OSMF.
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Kakar, P. K., R. K. Puri, and V. P. Venkatachalam. "Oral Submucous Fibrosis—treatment with hyalase." Journal of Laryngology & Otology 99, no. 1 (January 1985): 57–60. http://dx.doi.org/10.1017/s0022215100096286.
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AbstractOral Submucous Fibrosis (OSMF) is a disease of unknown etiology. A total of 96 patients with Oral Submucous Fibrosis have received four regimens of treatment–local dexamethasone, local hyaluronidase, local combination of dexamethasone and hyaluronidase, and local placental extract. The patients were followed up for a period varying from 3 months to 2 years. The group of patients receiving hyaluronidase alone showed quicker improvement in symptoms although its combination with dexamethasone gave somewhat better longer-term results. A new regimen for the treatment of submucous fibrosis is recommended.Oral Submucous Fibrosis is a well-known clinical entity, known since the time of Sushurta. In the modern literature, this condition was first reported by Schwartz (1952). Joshi (1953) was the first person to describe this entity in India.Oral Submucous Fibrosis has been defined as an insidious chronic disease of unknown etiology, reported mainly in Indians, and affecting the entire oral cavity. The basic change is a fibro-elastotic transformation of the connective tissue in the lamina propria preceded by vesicle formation. In its later stages the oral mucous membrane becomes stiff and the patient suffers from trismus and resultant difficulty in eating (Pindborg and Sirsat, 1966).The present paper deals with our experience in the management of Oral Submucous Fibrosis over the past 21/2 years.
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Prabhu, K., Hitendra Prakash Singh, Sunil Kumar, Malti Kumari Maurya, Veerendra Verma, Anupam Mishra, and Satya Prakash Agarwal. "Oral Submucous Fibrosis- Correlation between Clinical Findings and Histopathological Grading." Bengal Journal of Otolaryngology and Head Neck Surgery 26, no. 2 (August 29, 2018): 91–98. http://dx.doi.org/10.47210/bjohns.2018.v26i2.166.
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Introduction
Oral Submucous fibrosis (OSMF) occurs in young adults, who are in the habit of chewing tobacco mixed with areca nut and its various commercially available preparations. The disease results in progressive inability to open the mouth due to the submucosal fibrosis initiated by chronic inflammation affecting mainly oral mucosa. Authors undertook the present study to correlate the clinical features of OSMF to histopathological features and to find out aetiopathological factors of this condition.
Materials and Methods
A total of 123 clinically diagnosed OSMF patients, in the age range of 17 to 70 years were studied. Mouth opening was measured using a scale and was recorded in millimeters. Incisional biopsy was taken from the representative areas in the oral cavity. The patients were graded clinically and histopathologically and results were analyzed and discussed.
Result
Most of the patients were in the age group of 20-30 years (37.4%) with male predominance. The duration of either tobacco or areca nut chewing ranged from 1 to 35 yrs. Most patients had these habits for 6-19 yrs. Majority (55.3% & 54.5%) of the patients belonged to grade-2 (clinical grading) and intermediate grade (HPE grading) respectively. The HPE grading showed significant and direct association with duration of ill habits. The HPE grading showed significant and direct association with clinical grading (χ2=204.08, p<0.001).
Discussion
The HPE grading showed significant and direct association with duration of ill habits and also with clinical findings of restriction of mouth opening and inter incisal distance. The HPE findings showed significant and direct association with clinical grading i.e. when the clinical grading increases, the histopathological grading also increases.
Conclusion
OSMF is a disease with a high incidence. It also carries a significant risk of transformation to oral cancer. As no effective medical and surgical treatment is available for this condition; it is desirable to diagnose OSMF at early stages.
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Rajendran, R., T. Vijayakumar, and D. M. Vasudevan. "An alternative pathogenetic pathway for oral submucous fibrosis (OSMF)." Medical Hypotheses 30, no. 1 (September 1989): 35–37. http://dx.doi.org/10.1016/0306-9877(89)90122-9.
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Tupkari, JV, JD Bhavthankar, and MS Mandate. "Oral Submucous Fibrosis (OSMF) : A study of 101 cases." Journal of Indian Academy of Oral Medicine and Radiology 19, no. 2 (2007): 311. http://dx.doi.org/10.4103/0972-1363.168415.
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Raja Lakshmi, Chintamaneni, Dharmavaram Ayesha Thabusum, and Sujana Mulk Bhavana. "An Innovative Approach to Evaluate the Morphological Patterns of Soft Palate in Oral Submucous Fibrosis Patients: A Digital Cephalometric Study." International Journal of Chronic Diseases 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/5428581.
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Oral submucous fibrosis (OSMF) is a chronic insidious disease affecting mucosa and submucosa of oral cavity and soft palate. The present study aimed to evaluate the morphology of soft palate in normal individuals and OSMF patients using lateral cephalometry and to compare and correlate these variants of soft palate with different stages of OSMF. 100 subjects were included in the study, who were divided into two groups. Group I included 50 subjects with clinical diagnosis of OSMF and Group II included 50 normal subjects (control group). Using digital lateral cephalometry, velar length and width were measured and soft palatal patterns were categorized based on You et al.’s classification. Leaf and rat-tail patterns of soft palate were predominant in control group, whereas butt and crook shaped variants were more in study group. Anteroposterior (A-P) length of soft palate was significantly greater in stage I OSMF, while superoinferior (S-I) width was greater in stage III OSMF. Interestingly, a negative correlation was observed in staging of OSMF and A-P dimensions. As the staging of OSMF advances, the A-P length of soft palate decreases, but S-I width increases.
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SONAR, PRASANNA. "Conservative Approach In The Treatment Of Oral Submucous Fibrosis: A Review." DMIMS Journal of Dental Research 6, no. 2 (July 1, 2022): 80–85. http://dx.doi.org/10.54054/jodr.20226210.
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Oral submucous fibrosis is a crippling disorder with potential for malignant transformation.The clinical manifestations of OSMF are determined by the stage of the disease at the time of diagnosis.Oral submucosal fibrosis clinical management becomes more complicated, variety of therapy approaches are employed to manage it. The chief goalintreatment of OSMF is to alleviate signs and symptoms, slow the development of the condition, and reduce the chance of a cancerous transformation.Use of antioxidants, vitamins and minerals demonstrates improvement in the condition. There has not been a single medicine that has completely cured OSMF symptoms, hence combining the treatment regimens can be a basis for management of OSMF.In the early phases of OSMF can be benefitted with patient counselling for complete habit cessation, physiotherapy exercises as well as lycopene, multivitamin, minerals, etccan be tried. Ayurvedic treatment modalities like spirulina, tulsi, aloe vera, turmeric, ashwagandha can be used as adjuvant therapies. High-quality research should be done to further analyse the outcomes of different pharmaceutical formulations in the OSMF’s management when combined with physio therapy. The present review work is undertaken with the purpose to explore various medicinal modalities that can be used in the management of OSMFevaluating their merits and demerits
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R, Preethi, Malarkodi T, Arvind Krishnamurthy, and Aravind Warrier S. "Coetaneous Presentation of Oral Leukoplakia and Oral Submucous Fibrosis with High Grade Dysplasia and Its Management with Lasers: A Case Report." International Journal of Innovative Research in Medical Science 6, no. 08 (August 2, 2021): 464–69. http://dx.doi.org/10.23958/ijirms/vol06-i08/1167.
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Oral potentially malignant disorders (OPMD) are diverse lesions associated with an increased likelihood for malignant transformation to oral cancer. The most frequently encountered OPMD in clinical practice are Oral Leukoplakia and oral submucous fibrosis (OSMF). The use of tobacco is consistently linked with leukoplakia and areca/betel nut with OSMF. Histopathological features of oral epithelial dysplasia, its varying grades are of immense clinical significance to evaluate its ability for malignant transformation. We report a case of homogenous leukoplakia and OSMF, two oral potentially malignant disorders occurring at the same site with high-grade dysplasia and its management using lasers.
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Kalra, Sukhjinder Kaur, Alok A. Lathi, and Shilpa A. Lathi. "A Comprehensive Review of Etiopathogenesis of Oral Submucous Fibrosis." International Journal of Head and Neck Surgery 6, no. 2 (2015): 76–79. http://dx.doi.org/10.5005/jp-journals-10001-1227.
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ABSTRACT Accepted as an Indian disease, oral submucous fibrosis, is considered not only a chronic debilitating disease but a poten tially malignant condition of oral cavity, strongly associated with the habit of betel nut chewing, that has been sporadically detected in many other western countries and various conti nents, posing a reason for concern in order to create awareness for such debilitating disease. This article provides an overview of the recent concepts and exact role of areca nut alkaloids and other etiological factors in the pathogenesis of oral submucous fibrosis (OSMF). How to cite this article Kalra SK, Lathi AA, Lathi SA. A Com prehensive Review of Etiopathogenesis of Oral Submucous Fibrosis. Int J Head Neck Surg 2015;6(2):76-79.
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Shetty, Shishir Ram, Sesha Reddy, Pooja Narain Adtani, Raghavendra Shetty, Ashwin Lakshminarayanan, Shakeel Santerbennur Khazi, and Venkata Ramana Vannala. "Quality of Life in Oral Submucous Fibrosis- A Case Report with a Literature Review." Open Dentistry Journal 15, no. 1 (February 15, 2021): 4–10. http://dx.doi.org/10.2174/1874210602115010004.
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Introduction: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder commonly found in the Southeast Asian region, classically characterized through restricted mouth opening and burning sensation in the mouth on consuming spicy food. The etiopathogenesis and treatment aspects of OSMF have been extensively researched and reviewed. However, the effect of this condition on the Quality of Life (QoL) of patients has not gained much consideration. The aim of our case report is to highlight the importance of evaluating the QoL in an OSMF patient by using discipline-specific questionnaire and also to present to the readers a review of the recently published research articles on the application of QoL questionnaires in OSMF patients. Results: It was observed that most of the researchers used generic and discipline-specific questionnaire for evaluating the quality of life in OSMF patients. Conclusion: Evaluation of QoL is recommended during the treatment of OSMF patients. There is a need to develop and employ more of disease-specific QoL instruments for OSMF patients.
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Tahir, Sasui Soonh, Muhammad Shahzad, Uzma Tariq, Shirjeel Husain, Bhavesh Maheshwari, and Navid Rashid Qureshi. "Estimation of Serum Iron in the Patients of Oral Submucous Fibrosis." Pakistan Journal of Medical and Health Sciences 16, no. 7 (July 30, 2022): 529–31. http://dx.doi.org/10.53350/pjmhs22167529.
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Objective: To compare the serum levels of iron in Oral Submucous Fibrosis (OSMF) and normal healthy subjects. Subject and Methods: A total of 120 patients with symptoms and signs suggestive of OSMF equally divided into two groups named group A and B. Patients satisfying the insertion norms and those who has oral sub mucous fibrosis and the control group who are willing to get participate and getting done their blood tests for other purpose were asked for additional iron serum test for our research purpose. The demographic and medical factors like gender, pain, age, and medical record was known and logged in proforma. Diagnosis was done on clinical basis and was categorized according to progress then blood sample was obtained. The data was examined using SPSS version 20.0. Results: Control group's descriptive (standard/healthy) statistics indicate the mean iron levels of iron 94.13 ug/dl, while standard deviations are 17.57ug/dl. On the 1st day, 2nd day and 3rd day serum levels are examined, which reveal the mean values of 28.02, 22.81 and 24.0 ug/dl, respectively. The findings indicate a greater average of iron (17.57) in the healthy group (group B), while considerably less mean of iron level (6.47) in patients who have OSMF (group A). Conclusion: The study concluded that OSMF have lower levels of the iron in the serum while higher levels in the healthy group. Keywords: Serum Iron Level, Oral Submucous Fibrosis, Estimation
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Patil, Santosh R., G. Maragathavalli, D. N. S. V. Ramesh, and Mohammad Khursheed Alam. "Muscle Activity in Pre-Treatment and Post-Treatment Oral Submucous Fibrosis Patients: Electromyography Study." International Journal of Clinical Practice 2022 (September 30, 2022): 1–8. http://dx.doi.org/10.1155/2022/2826862.
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Background. Oral submucous fibrosis (OSMF) is a premalignant condition of insidious onset which affects the oral mucosa, pharynx, and esophagus. The muscles of mastication are known to be affected resulting in limited mouth opening. Electromyography (EMG) is a sophisticated method of measuring and evaluating muscle activity. Previously, EMG was primarily utilized in medical sciences, but it is currently being used extensively in both the medical and dentistry fields. Objectives. The aim of the study is to evaluate the electromyographic activity of masseter muscle in OSMF patients before and after treatment and to compare with healthy controls. Materials and Methods. This prospective case-control clinical study comprised 180 OSMF patients who were divided into four groups and 45 healthy individuals served as the control group. The OSMF individuals were injected with hyaluronidase 1,500 IU mixed in 1.5 ml of dexamethasone and 0.5 ml of lignocaine HCL intralesionally twice a week for one month along with a basic physiotherapy regimen consisting of mouth exercises two times daily. The control subjects were given placebo capsules. The treatment was carried out for a month and the electromyographic masseter muscle activity was evaluated among the OSMF patients and control group before and after treatment. Results. The results revealed that the electromyographic activity of master muscles in OSMF patients showed increased activity when compared with healthy controls. Patients with OSMF showed decreased muscle activity after treatment. Conclusion. When compared with healthy controls, OSMF patients had higher electromyographic activity of the masseter muscles and the muscle activity was decreased following treatment. In OSMF patients, EMG may help in determining the involvement of the mastication and facial expression muscles. It can also be used as a diagnostic tool to assess the treatment outcome of muscle activity in OSMF patients.
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Ganjre, Anjali P. "Interrelationship of Autophagy and Oxidative Stress in Malignant Transformation of Oral Submucous Fibrosis." World Journal of Dentistry 8, no. 2 (2017): 139–44. http://dx.doi.org/10.5005/jp-journals-10015-1427.
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ABSTRACT Oral submucous fibrosis (OSMF) is a potentially malignant disorder. Malignant transformation is a major concern related with OSMF. Despite array of studies discussed, pathogenic factors responsible for carcinogenesis in OSMF is still a field of research. Autophagy is a degradation of unwanted cytoplasmic material to maintain cellular biosynthesis when cell is under metabolic stress. Tissue microenvironment consists of diverse mechanisms. It is found that the autophagy has a major impact on these mechanisms to maintain homeostasis. However, dysregulated autophagy has been involved in disruption of the homeostasis and leads to formation of various diseases including cancer. Altered autophagy enhances oxidative stress in the cell which is a critical cause of genetic instability and oncogenesis. Plethora of studies supports that autophagy is implicated in carcinogenesis process and are interlinked with each other. In OSMF, areca nut causes increase in production of reactive oxygen species and formation of oxidative stress which is being wielded by autophagy. Furthermore, modulated autophagy has an impact on senescence and immunity which can lead to cancer. There is an explicit cause and effect relationship present between autophagy and oncogenesis in OSMF. It is our sincere efforts to elucidate this relationship in OSMF so that it can be incorporated in therapeutic purpose at an early stage. How to cite this article Ganjre AP. Interrelationship of Autophagy and Oxidative Stress in Malignant Transformation of Oral Submucous Fibrosis. World J Dent 2017;8(2):139-144.
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Nagar, Kavita, G. P. Sujatha, and Ashok Lingappa. "Evaluation of Salivary Superoxide Dismutase Levels in Oral Submucous Fibrosis – A Cross Sectional Study." European Journal of Medical and Health Sciences 3, no. 3 (May 27, 2021): 34–37. http://dx.doi.org/10.24018/ejmed.2021.3.3.864.
Full textAbstract:
Background: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder with areca nut being the main etiological agent. Increased risk of malignant potential of OSMF necessitates the early diagnosis of the condition. Superoxide dismutase (SOD) scavenges oxygenated free radicals and can be used as a potential biomarker for oral cancer detection.
Objectives: The present study was conducted to estimate and compare salivary SOD levels in patients with OSMF and healthy controls and to compare its levels in different clinical and functional stages of OSMF.
Methodology: The study group (Group 1) included 30 patients of OSMF, and the control group (Group 2) was formed by age and sex-matched healthy individuals. Salivary SOD levels were determined by Nitro Blue Tetrazolium (NBT) chloride method. The levels of salivary SOD were compared between the two groups and the data thus obtained was subjected to statistical analysis using independent sample t-test and one way Analysis of variance (ANOVA) test.
Results: The mean salivary SOD in the study group was 0.583 IU/mL and 0.864 IU/mL in control group and the difference was found to be statistically significant. Thus, the patients with OSMF had significantly lower levels of salivary SOD compared to the controls.
Conclusion: The decrease in the salivary SOD levels in patients with OSMF suggests the role of oxidative stress in the pathogenesis of OSMF and initiation and progression of carcinogenesis. Thus, it can be used as a prognostic marker for early detection of carcinoma in patients with OSMF and thereby, improving the quality of life patients.
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Kulkarni, Venkatesh V., Aditi R. Chaudhari, and Aishwarya S. Kulkarni. "Comparison of dermatoglyphic patterns in oral leukoplakia and oral submucous fibrosis patients." International Journal of Research in Medical Sciences 8, no. 1 (December 25, 2019): 153. http://dx.doi.org/10.18203/2320-6012.ijrms20195899.
Full textAbstract:
Background: Genetics plays an important role in the detection of an Oral potentially malignant lesion. A major contributor to genetic study is Dermatoglyphics or the study of fingerprints and lines of palmer and plantar surfaces. Many researchers have used dermatoglyphics to connect genetics with oral lesions and malignancies. Thus, the current study has been conducted to find out an association between dermatoglyphic patterns and oral leukoplakia, oral submucous fibrosis and healthy subjects.Methods: The present study is conducted on subjects that have been already diagnosed with oral lesions. Fingerprint patterns (whorled, loop and arch) were evaluated by utilizing fingerprints.Results: The present study showed that the loop pattern was common in all three subjects. The frequency of whorled and arch pattern is decreased in oral leukoplakia and oral submucous fibrosis that healthy subjects. Arch pattern is comparatively decreased in subjects with oral leukoplakia than oral submucous fibrosis and there is a decrease in the frequency of whorled patterns in OSMF as compared to oral leukoplakia.Conclusions: Authors conclude that simply by observing the whorled and arch patterns in a subject, authors can hypothesize that risk of occurrence of oral leukoplakia and oral submucous Fibrosis and take preventive measures against the said lesions.