Academic literature on the topic 'Oral Tongue Cancer'
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Journal articles on the topic "Oral Tongue Cancer"
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Choi, Eun Chang. "Oral Tongue Cancer." Journal of Clinical Otolaryngology Head and Neck Surgery 14, no. 1 (2003): 40–45. http://dx.doi.org/10.35420/jcohns.2003.14.1.40.
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S, Franjić. "In Shortly about Cancer of the Tongue." Journal of Health Care and Research 1, no. 1 (2020): 7–11. http://dx.doi.org/10.36502/2020/hcr.6152.
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Cancer of the tongue is a type of oral cancer that occurs in the front two-thirds of the tongue. If cancer occurs at the back of the tongue, then it is a type of head or neck cancer. These cancers are extremely rare and occur in a small number of cases. Cancer in the front of the tongue also does not occur as often, but it is the most common type of oral cancer. Cancer of the tongue mainly occurs in squamous cells – thin, flat cells that are found on the surface of all soft tissues, and therefore the tongue. Cancer of the tongue is a disease that affects the front of the tongue, while cancer in the back of the tongue is called oropharyngeal cancer. Symptoms that indicate tongue cancer are pain in the jaw or throat, pain during swallowing, feeling that there is something in the throat, stiff tongue or jaw, problem with chewing and swallowing food, white or red stamps in the mouth or tongue, ulcer on non-healing tongue, pimples in the mouth, bleeding tongue and growths on the tongue.
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Olaleye, O., U. Ekrikpo, O. Lyne, and J. Wiseberg. "Incidence and survival trends of lip, intra-oral cavity and tongue base cancers in south-east England." Annals of The Royal College of Surgeons of England 97, no. 3 (2015): 229–34. http://dx.doi.org/10.1308/003588414x14055925061676.
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Background Oral cavity cancers are on the increase in the UK. Understanding site-specific epidemiological trends is important for cancer control measures. This study demonstrates the changing epidemiological trends in lip, intra-oral cavity and tongue base cancers in south-east England from 1987 to 2006. Aim: Methods This was a retrospective study using anonymised data obtained from the Thames Cancer Registry (TCR) London. Data were analysed using SPSS v.17 and survival analyses with Kaplan-Meier and Cox regression. Age standardisation of the incidence rates was performed. It was conducted in south-east England, which has an average population of 12 million. The study analysed 9,318 cases (ICD-10 code C00–C06, C14). Kent Research Ethics Committee UK granted ethical approval. Results Oral cancers were more common in men, with male: female ratio of 1.6:1. Tongue cancers had the highest frequency at 3,088 (33.1%). Incidence varied with each cancer type. Mean incidence (per 1,000,000) ranged from 2.3 (lip cancer) to 13.8 (tongue cancer). There has been a statistically significant increase in incidence for cancers of the tongue base, other parts of tongue, gum and palate (p<0.001). Median survival time varied by sub-site, with lip cancer having the best median survival time (11.09 years) compared with tongue base cancer (2.42 years). Survival analyses showed worse prognosis for men, older age at diagnosis, and presence of synchronous tumours (p<0.001). Conclusion There is a rising incidence of tongue and tongue base, gum and palate cancers in south-east England with wide variability in survival. Oral cancer awareness and screening programmes should be encouraged.
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Brown, Linda Morris, David P. Check, and Susan S. Devesa. "Oral Cavity and Pharynx Cancer Incidence Trends by Subsite in the United States: Changing Gender Patterns." Journal of Oncology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/649498.
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Objective. To evaluate oral cavity and pharynx cancer (OCPC) patterns by gender.Methods. We used Surveillance, Epidemiology, and End Results program data for 71,446 cases diagnosed during 1975–2008 to classify OCPC by anatomic subsite as potentially HPV-related or not, with oral tongue cancer considered a separate category.Results. Total OCPC rates among men were 2–4 times those among women. Among whites, total OCPC rates rose in the younger age groups due to substantial increases in successive birth cohorts for HPV-related cancers, more rapid among men than women, and oral tongue cancers, more rapid among women than men. Among blacks, total OCPC rates declined among cohorts born since 1930 reflecting the strong downward trends for HPV-unrelated sites. Among Hispanics and Asians, HPV-unrelated cancer rates generally declined, and oral tongue cancer rates appeared to be converging among young men and women.Conclusions. Decreases in total OCPC incidence reflect reductions in smoking and alcohol drinking. Rising HPV-related cancers among white men may reflect changing sexual practices. Reasons for the increasing young oral tongue cancer rates are unknown, but the narrowing of the gender differences provides a clue.
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Shibata, Tomohisa, Daisuke Yamashita, Shingo Hasegawa, et al. "Oral candidiasis mimicking tongue cancer." Auris Nasus Larynx 38, no. 3 (2011): 418–20. http://dx.doi.org/10.1016/j.anl.2010.11.007.
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Windon, Melina, Carole Fakhry, Lisa Rooper, et al. "The Role of Age and Merkel Cell Polyomavirus in Oral Cavity Cancers." Otolaryngology–Head and Neck Surgery 163, no. 6 (2020): 1194–97. http://dx.doi.org/10.1177/0194599820932553.
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The incidence of oral tongue cancer, the majority subsite of oral cavity cancer, is rising among young people with less exposure to tobacco and alcohol. Viral causes have been proposed, including Merkel cell polyomavirus (MCPyV). We evaluated patient and tumor characteristics among 126 incident oral cavity cancers (OCCs). Consistent with generational norms, younger patients had less exposure to tobacco and a greater number of oral sexual partners than older OCCs. In addition, younger patients were more likely to present at an earlier stage and with cancer arising from the oral tongue (each P < .05). A subset of 44 cases was centrally tested for MCPyV large T antigen expression by immunohistochemistry. In the presence of controls, none of the tumors expressed MCPyV. These findings exclude consideration of MCPyV as an etiologic factor in OCC and may generate hypotheses for future examinations of the factors underlying the rise in oral tongue cancers.
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Riju, Jeyashanth, Amit Jiwan Tirkey, Malavika Babu, et al. "Difference in clinical presentation and their significance in oral squamous cell carcinoma: A retrospective analysis." Journal of Cancer Research and Therapeutics 19, Suppl 2 (2023): S685—S690. http://dx.doi.org/10.4103/jcrt.jcrt_767_22.
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ABSTRACTS Background: Oral squamous cell carcinoma (OSCC) remains the most common cancer among Indian men. OSCC involving the tongue and bucco alveolar complex (BAC) behaves differently. Nevertheless, the differences in clinical features and symptoms between the two subsites and their relation to pathology remain largely unexplored. Study Design: The study compared various clinical parameters and pathological factors between tongue cancer patients and patients with BAC cancer. Results: Among 474 patients, 232 had tongue cancer and 242 had BAC cancer. Except for the ulcer, 30% of patients with OSCC were asymptomatic at presentation. Compared to tongue cancers, lesions confined to BAC present at an advanced stage (P = 0.006). Multivariate analysis showed that dysphagia in tongue cancer (P = 0.020) and external swelling or lesion in BAC cancers (P = 0.002) were significant predictors of an advanced stage of the disease. On histopathology, perineural invasion (PNI) was significantly associated with tongue (P = 0.008) compared to BAC cancers (P = 0.015). Cancers of the tongue with pain and referred otalgia had a significantly higher depth of invasion (DOI), compared to those without pain (DOI – no pain 6.9 mm, pain 9.9 mm, and referred otalgia 11.4 mm). Conclusions: Patients with OSCC present late and in an advanced stage of the disease. Among tongue cancers, clinical history of pain was significantly associated with DOI and PNI, the significance of which needs to be prospectively analyzed. Clinical history in OSCC can be used as predicting factor for an advanced pathological stage of the disease. It also had an influence on various pathological characters, which is subsite specific.
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N, Parvataneni, Devarakonda KK, Gilkarl IH, et al. "Deep margin assessment by intraoperative ultrasound in tongue cancer- dust trial." Journal of Medical and Scientific Research 12, no. 02 (2024): 138–42. http://dx.doi.org/10.17727/jmsr.2024/12-26.
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Introduction: Oral cancer ranks sixth among all cancers globally and India has the most significant number of cases, one-third of the total burden of oral cancer cases globally. The aim of the study was to conduct deep margin assessment using intraoperative ultrasound in superficial oral tongue carcinomas, ensuring adequate surgical resection for early-stage oral tongue cancer minimizing loco regional recurrence risks. Methodology: This is a prospective observational study involving 91 diagnosed tongue malignancies. The study included biopsy verified tongue cancer. During the surgical procedure and effect of general anaesthesia the tongue lesions of the patient were evaluated with intraoral sonography. An intraoral transducer probe characterized by an 8 to 10 MHz ultrasonic beam Siemens Acuson NX3 was used to assess the deep margin, tumor thickness, margins, and other findings like lingual nodes are noted. Results: A total of 91 patients that underwent resection using intraoperative USG were included in the study. The majority of the patients were in the age group 41 - 60 years. As carcinoma tongue is more common in males our study has a sex distribution of 63 male and 28 females. The mean deep margin assessed by USG - is 0.901cm and the mean deep margin assessed by the frozen section is 0.762 cm. The mean deep margin assessed by final histology is 0.748 cm. Conclusion: USG guided resection of early tongue cancers is a technique that is able to increase the frequency of free margins and decrease the close margin and positive margin frequency when compared to conventional treatment. USG being noninvasive is a very fast method in comparison to the frozen section and seems to be a promising technique. Larger studies are needed with control groups to possibly confirm a statistically significant difference in adequate deep resection margin and improvement in DSS and quality of life in future. Keywords: deep margin; tongue; carcinoma
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Yip, Connie SP, Tze Choong Charn, Joseph TS Wee, et al. "Outcomes of Oral Tongue Cancer: Does Age Matter?" Annals of the Academy of Medicine, Singapore 39, no. 12 (2010): 897–903. http://dx.doi.org/10.47102/annals-acadmedsg.v39n12p897.
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Introduction: This is a retrospective study aimed to analyse the outcomes of oral tongue cancer with emphasis on young people. Materials and Methods: Patients treated radically between 1998 and 2006 were included and categorised according to treatment modalities (Group A: Surgery, Group B: Surgery and adjuvant therapy, Group C: Definitive radiotherapy) and age groups (≤40 and > 40 years). Overall survival (OS), disease-free survival (DFS), locoregional relapse-free survival (LRS) and metastasis-free survival (MFS) were estimated using Kaplan-Meier method. Results: There were 123 patients with 32%, 53% and 15% in Group A, B and C, respectively. Of these, 17 patients (14%) were ≤40 years with 6 (15%), 8 (12%) and 3 (16%) young oral tongues in Group A, B and C, respectively. Five-year OS and DFS were 69%/72%, 41%/47% and 16%/9.5% for Group A, B and C, respectively. Young patients had similar survival as the older population with 5-year OS of 83%, 75% and 33% in Group A, B and C, as compared to the older patients (66%, 36% and 13%, respectively). Conclusion: Young oral tongue patients did not have worse outcomes. Keywords: Head and neck, Squamous cell carcinoma, Young
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Goldenberg, David, Mathew Provanzano, Wayne M. Koch, and James J. Sciubba. "Oral Tongue Cancer in the Young." Otolaryngology–Head and Neck Surgery 131, no. 2 (2004): P245. http://dx.doi.org/10.1016/j.otohns.2004.06.491.
Full textDissertations / Theses on the topic "Oral Tongue Cancer"
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Rahman, Ashequr. "Prevention of Tongue Cancer at an Individual Level." Thesis, Faculty of Dentistry, 1990. http://hdl.handle.net/2123/4233.
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Yuen, Po-wing, and 袁寶榮. "The study of nodal metastasis of oral tongue carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39793837.
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Kantola, née Kari S. (Saara). "Cancer of the tongue in Finland:incidence, detection, survival and prognostic factors." Doctoral thesis, University of Oulu, 2000. http://urn.fi/urn:isbn:9514258037.
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Abstract
A population-based study was conducted to determine the trends in incidence and
survival of cancer of the mobile tongue in Finland over the past 40 years.
Possible changes in patient and tumour characteristics, early detection and
prognostic factors of cancer of the mobile tongue were monitored in a
geographically defined area of Northern Finland over the past 20 years. There
were 1504 new cases with cancer of the mobile tongue in 1953-1994 in Finland and
105 cases in 1974-1994 in Northern Finland. An increasing trend in incidence of
cancer of the mobile tongue was observed over the past 20 years both nationwide
and in Northern Finland. The stage distribution of the cancer of the mobile
tongue remained very much the same throughout the study period. Despite the
increasing incidence rate and unchanged stage distribution of the tumours, the
5-year relative survival rate of cancer of the tongue improved from 40% to 58%
in the 40-year study period in Finland.
To evaluate the detection of cancer of the tongue, patients' primary care files
were reviewed. It was revealed that the diagnostic skills of the
physician/dentist first contacted by the patient had a significant effect on the
patient's prognosis. If the cancer was not detected at the primary visit and no
follow-up was scheduled, the delay was often fatally long. The most important
factor influencing the referral pattern was the patient's primary symptom at the
initial visit. The more closely the symptom was related to the tongue, the more
likely the patient was correctly referred.
To recognise aggressively behaving early stage (Stages I-II) cancers of the
tongue, various prognostic factors were analysed. It was observed that an old
age (65+years) of the patient, a high malignancy score of the tumour and the
absence of p53 predicted poor prognosis in early stage carcinomas. Patients with
these qualities may require more aggressive initial therapy.
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Sundquist, E. (Elias). "The role of tumor microenvironment on oral tongue cancer invasion and prognosis." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526217659.
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Abstract Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity. The 5-year mortality of OTSCC remains at about 50%. The tumor microenvironment (TME) is now recognized as an important factor in cancer progression and metastasis, as well as a tool for prognostication. The aim of this study was to elucidate the roles of TME hypoxia and soluble factors on cancer cell migration and invasion, and the prognostic value of two extracellular matrix (ECM) molecules: tenascin-C (TNC) and fibronectin (FN). Hypoxia was studied using oral squamous cell carcinoma cells in migration and invasion assays. Invasion assays were carried out using a 3D-myoma invasion method. Similarly, the effect of soluble factors as well as ECM alterations were studied using the myoma model: the effect of soluble factors was studied by rinsing the myoma discs prior to experiments, and ECM alterations by lyophilizing and rehydrating. ECM was further studied by analyzing the prognostic value of TNC and FN from OTSCC samples. The effect of hypoxia was shown to be OTSCC cell line dependent: the effect of hypoxia on migration and invasion was increased in aggressive cell lines. Additionally, the response to hypoxia was altered in rinsed tissue. Tissue rinsing media were analyzed and factors affecting cell motility were found. The TME was found to be pivotal for cancer invasion: invasion was impaired in non-neoplastic tissue. Furthermore, changes in the ECM by lyophilization and rehydration led to a change in the invasion mechanism. High expression of stromal TNC and FN were excellent prognosticators in early-stage OTSCC. In conclusion, the present study highlighted the role of various TME components in cancer cell invasion as well as prognostication in OTSCC. Additionally, this study provided feasible tools for more precise diagnosis of early-stage OTSCC<br>Tiivistelmä Liikkuvan kielen levyepiteelikarsinooma (OTSCC) on suuontelon yleisin syöpä. Viiden vuoden kuolleisuus OTSCC:an on edelleen noin 50 %. Kasvaimen mikroympäristön (TME) tiedetään nykyään olevan tärkeässä roolissa syövän kehityksessä ja etäpesäkkeiden muodostuksessa, sekä tarjoavan työkaluja ennusteiden laadintaan. Tämän tutkimuksen tarkoituksena oli selvittää TME:n hypoksian ja liukoisten tekijöiden vaikutusta syöpäsolujen liikkumiseen ja invaasioon ympäröivään kudokseen, sekä tutkia kahden solunulkoisen matriksin (ECM) proteiinin, tenaskiini-C:n (TNC) ja fibronektiinin (FN), vaikutusta OTSCC:n ennusteeseen. Hypoksian vaikutusta tutkittiin käyttäen suun levyepiteelikarsinoomasoluja liikkuvuus- ja invaasiokokeissa. Invaasiokokeissa hyödynnettiin kolmiulotteista ihmisen myoomaan perustuvaa invaasiomallia. Myös liukoisten tekijöiden ja ECM:n muutosten vaikutusten tutkimisessa käytettiin myoomamallia: liukoisten tekijöiden vaikutusta tutkittiin huuhtomalla myoomakiekot ennen niiden käyttämistä, ja ECM:n muutosten vaikutusta kylmäkuivaamalla ja uudelleen nesteyttämällä myoomakiekot. ECM:ia tutkittiin myös analysoimalla TNC:n ja FN:n värjäytyvyyden merkitystä OTSCC:n ennusteessa. Hypoksian vaikutus osoittautui solulinjariippuvaiseksi: hypoksia lisäsi kielisyöpäsolujen liikkuvuutta ja invaasiota eniten aggressiivisimmilla solulinjoilla. Lisäksi solujen vaste hypoksialle oli erilainen huuhdotussa kudoksessa. Huuhteluliuos analysoitiin ja siitä löydettiin solujen liikkumiseen vaikuttavia tekijöitä. TME:n havaittiin olevan ratkaisevassa roolissa syöpäsolujen invaasiossa: syöpäsolut eivät kyenneet invasoitumaan lainkaan ei-neoplastiseen kudokseen. Lisäksi muutosten ECM:ssä havaittiin johtavan muutoksiin solujen käyttämässä invaasion mekanismissa. Strooman TNC:n ja FN:n värjäytyvyyden todettiin olevan erinomaisia ennustekijöitä aikaisen vaiheen OTSCC:ssa. Tiivistettynä voidaan todeta, että tämä tutkimus alleviivasi useiden TME:n komponenttien vaikutusta syövän invaasiolle ja ennusteelle OTSCC:ssä. Lisäksi se tarjoaa käyttökelpoiset työkalut (TNC ja FN) tarkemmalle diagnostiikalle aikaisen vaiheen OTSCC:ssä
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Åström, P. (Pirjo). "Regulatory mechanisms mediating matrix metalloproteinase-8 effects in oral tissue repair and tongue cancer." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526206103.
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Abstract Tissue repair and cancer progression involve similar mechanisms, including degradation of extracellular matrix in which matrix metalloproteinases (MMPs) play essential roles. The action of MMPs is important in normal physiological processes but MMPs also contribute to various pathological conditions. MMP-8 belongs to a family of collagenases with a diverse set of substrates. MMP-8 action is involved in skin wound healing and in various human cancers. The function of MMP-8 in cancer appears to be highly complex and varies depending on the cancer type and location. Little is known about the involvement of MMP-8 in oral physiology and pathology. The aim of this study was to clarify the role of MMP-8 in oral tissue repair and oral tongue squamous cell carcinoma (OTSCC). Studies with MMP-8 deficient mice revealed that the function of MMP-8 in tissue repair is highly dependent on the spatial aspects. In alveolar bone, MMP-8 increased inflammation and affected collagen metabolism. In tongue wounds, MMP-8 impaired early healing and reduced transforming growth factor (TGF) -β1 levels. This study also revealed the protective role of MMP-8 in OTSCC patients, in agreement with previous studies indicating positive features of MMP-8 in cancer. Low MMP-8 level and high vascular endothelial growth factor (VEGF) -C levels in tumors correlated with worse prognosis in these patients. In mouse tongue fibroblast cell cultures, MMP-8 reduced TGF-β1 signaling molecule phosphorylated Smad2 levels and impaired the collagen contraction ability. TGF-β1, apoptosis factor Fas-ligand (Fas-L) and estrogen receptors (ERs) were identified as novel MMP-8 substrates. In OTSCC cell cultures, MMP-8 impaired cell migration and invasion. Diminished TGF-β1 levels were involved in the defective migration of MMP-8 overexpressing cells. Moreover, MMP-8 affected the expression of MMP-9, MMP-1, cathepsin-K, VEGF-C and TGF-β1. In mouse models of OTSCC, MMP-8 protected against tumor development but was not able to prevent metastasis formation. The main findings of this study were that 1) MMP-8 action in tissue repair depends on the site of the injury and 2) in OTSCC, MMP-8 has tumor suppressive effects, but in mouse, MMP-8 does not inhibit metastasis formation. In addition, 3) four novel MMP-8 substrates (TGF-β1, Fas-L, ER-α and -β) were identified that may explain the spatial and diverse roles of MMP-8<br>Tiivistelmä Kudosvaurioiden paranemiseen ja syövän etenemiseen liittyy useita samankaltaisia mekanismeja. Molemmissa toimivat soluvälitilan muokkaamiseen osallistuvat proteaasit, joista matriksin metalloproteinaaseilla (MMP) on tärkeä merkitys; ne osallistuvat lukuisiin elimistön keskeisiin fysiopatologisiin prosesseihin. Kollagenaasi MMP-8 muokkaa monentyyppisiä molekyylejä. Se on mukana ihohaavan paranemisessa ja useissa syövissä. MMP-8:n toiminta syöpätiloissa on hyvin moninainen riippuen syöpätyypistä ja sijainnista. Väitöstutkimuksessa selvitettiin MMP-8:n merkitystä suun kova- ja pehmytkudosvaurioprosesseissa sekä kielisyövässä, joissa se on ollut tuntematon. MMP-8 poistogeenisillä hiirillä tehdyissä pehmyt- ja kovakudoshaavoissa MMP-8:n vaikutusmekanismit riippuivat kohdekudoksesta. Alveoliluun paranemisen yhteydessä MMP-8 lisäsi tulehdusta ja osallistui kollageenin muokkaamiseen. Akuutin kielihaavan paranemisessa MMP-8 hidasti haavan umpeutumista ja vähensi transformoivan kasvutekijä-β1:n (TGF-β1) määrää. Kuten useissa muissakin syövissä, myös kielisyövässä todettiin MMP-8:lla olevan suojaava vaikutus. Potilaan ennuste huononi, jos kasvainsolukon matala MMP-8-taso yhdistyi korkeaan verisuonten kasvutekijä-C:n (VEGF-C) määrään. Hiiren kielen normaaleissa fibroblastiviljelmissä MMP-8 vähensi TGF-β1:n solunsisäistä signalointia välittävän fosforyloidun Smad2:n määrää sekä solujen kykyä supistaa kollageenikiekkoja. Koeputkessa MMP-8 pilkkoi TGF-β1:tä, estrogeenireseptoreja (ER) ja apoptoositekijä Fas-ligandia (Fas-L). Ihmisen kielikarsinoomasoluviljelmissä korkea MMP-8:n määrä vähensi solujen migraatiota ja invaasiota sekä muutti MMP-1:n, MMP-9:n, katepsiini-K:n, TGF-β1:n ja VEGF-C:n ilmentymistä. Migraation heikentyminen MMP-8:aa tuottavissa soluissa johtui osin vähentyneestä TGF-β1:n määrästä. Hiiren kokeellisissa kielisyövissä MMP-8 hidasti syövän muodostumista mutta ei estänyt etäpesäkkeiden muodostusta. Tässä väitöskirjatutkimuksessa on kolme päälöydöstä: 1) MMP-8:n vaikutus kudoksen paranemisprosessiin riippuu vauriokohdasta, 2) MMP-8 on kielisyövän kehittymisessä puolustuksellinen molekyyli, mutta sen lisääntynyt tuotto ei hiirikokeissa estänyt etäpesäkkeiden muodostusta, 3) MMP-8:lle löydettiin neljä uutta kohdemolekyyliä (TGF-β1, Fas-L, ER-α ja -β), joiden muokkaus saattaa osin selittää MMP-8:n monipuoliset kudos- ja prosessispesifit vaikutukset
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Väyrynen, O. (Otto). "Factors affecting aggressive oral tongue cancer invasion and development of in vitro models for chemoradiotherapy assay." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526222813.
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Abstract Tumor associated macrophages (TAMs) are linked to the invasion of oral tongue squamous cell carcinoma (OTSCC). We modified THP-1 leukemia cells to M1 (inflammatory), M2 (TAM-like) and R848 (imidazoquinoline-treated) type macrophages in order to examine their interactions with OTSCC-cells (HSC-3) by using different kinds of in vitro migration and invasion models. We observed that interaction of TAM-resembling M2-type macrophages with HSC-3 cells induced invasion and migration, whereas the influence of M1 macrophages reduced them. Patient response to chemoradiotherapy is highly reliant on the characteristics such as the aggressiveness and stage of the cancer. Therefore, new methods for treatment testing are needed in order to design personalized therapies. We tested the applicability and consistency of human TME mimicking tissue methods for analyzing the effects of chemoradiation using commercial OTSCC cell lines. Based on our trials, both our human uterine leiomyoma tissue -based matrix models provide viable platforms for future in vitro chemoradiotherapy testing. Conventionally pro-tumorigenic activities of matrix metalloproteinase (MMP)9 have been linked with oral squamous cell carcinoma, but recently its tumor-suppressor role has also been revealed. Our study provides strong evidence that MMP9 also has an anti-invasive effect in OTSCC and is a potential mediator of the protective effects of arresten in tongue cancer cells<br>Tiivistelmä Makrofageilla on yhteys kielen levyepiteelikarsinooman invaasioon eli syöpäkasvaimen tunkeutumiseen ympäröivään kudokseen. Tutkimuksessamme muokkasimme ihmisen THP-1 leukemiasoluja kemiallisesti tulehdusreittejä aktivoiviksi M1-makrofageiksi, kasvaimeen liittyvien makrofagien kaltaisiksi M2-makrofageiksi sekä imidatsokinoliini-käsitellyiksi R848-makrofageiksi. Tarkoituksenamme oli tutkia makrofagien ja kielisyöpäsolujen vuorovaikutuksia erilaisilla in vitro migraatio- ja invaasiomalleilla. Anti-inflammatoristen, syövän etenemistä edesauttavien TAM-makrofagien kaltaisiksi erilaistetut M2-tyypin makrofagit lisäsivät HSC-3 kielikarsinoomasolujen invaasiota ja migraatiota, kun taas M1-tyypin makrofagien vaikutus oli päinvastainen. Potilaan vaste kemosädehoitoon riippuu syöpäkasvaimen ominaisuuksista, kuten syöpäsolujen aggressiivisuudesta ja syövän levinneisyysasteesta. Tämän vuoksi on tarve uusille menetelmille, joiden avulla voidaan ottaa huomioon potilaan sekä syöpätyypin yksilölliset ominaisuudet hoitoa suunniteltaessa. Testasimme syöpäkasvaimen mikroympäristöä mallintavien, ihmiskudokseen perustuvien menetelmien käyttökelpoisuutta ja luotettavuutta kemosädehoidon vaikutusten arvioimiseen. Testiemme perusteella myoomakudokseen pohjautuvat menetelmät voivat auttaa kemosädehoidon vaikutusten testauksessa. Matriksin metalloproteinaasi (MMP) 9:n on pitkään uskottu olevan yksinomaan syövän etenemistä edesauttava molekyyli. Viimeaikaisissa tutkimuksissa on myös havaittu, että MMP9:llä voi olla syövältä suojaavia vaikutuksia. Tutkimme MMP9:n vaikutusta kielisyöpäsoluihin ja havaitsimme, että MMP9:llä on myös invaasiota hillitseviä vaikutuksia. Lisäksi MMP9 saattaa toimia verisuonten muodostumista estävän arresten-molekyylin syövältä suojaavien mekanismien välittäjänä
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MASCITTI, MARCO. "Sviluppo di un modello prognostico morfologico per il carcinoma squamocellulare della lingua." Doctoral thesis, Università Politecnica delle Marche, 2021. http://hdl.handle.net/11566/286953.
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Il carcinoma squamocellulare della lingua (OTSCC) è una neoplasia caratterizzata da un elevato tasso di recidive e da una mortalità stabile da oltre 20 anni. L’ottava edizione del sistema di stadiazione dell’AJCC ha migliorato la capacità di stratificare i pazienti affetti da OTSCC. Ciononostante, la capacità predittiva di tale sistema deve essere migliorata per poter discriminare quei pazienti affetti da una malattia più aggressiva, rendendo necessaria la ricerca di nuovi marcatori prognostici. Lo scopo di questo lavoro è stato quello di studiare le principali caratteristiche morfologiche del tessuto tumorale, sviluppando un modello prognostico e un nomogramma al fine di migliorare la stratificazione dei pazienti affetti da OTSCC. È stato condotto uno studio di coorte retrospettivo su 211 pazienti con OTSCC. Sono stati valutati vari parametri istopatologici sezioni seriali da 4 μm colorate con ematossilina-eosina: il pattern d’invasione tumorale, l’invasione perineurale (PNI), l’invasione linfovascolare (LVI), il budding tumorale (BT), l’eosinofilia associata al tumore (TATE), il tumor-stroma ratio (TSR) e l’immunofenotipo. Gli endpoint esaminati sono stati la sopravvivenza specifica da malattia (DSS) e la sopravvivenza libera da malattia (DFS). L’analisi univariata di Cox ha evidenziato una riduzione della DSS nei soggetti che presentavano lo Stadio avanzato (p<0,001), la PNI multifocale (p<0,001) e peritumorale (p=0,003), la LVI (p<0,001), il BT (p<0,001), la scarsa TATE (p<0,001), il TSR basso (p=0,001) e l’immunofenotipo deserto (p<0,001). L’analisi multivariata e la regressione stepwise hanno permesso di costruire un modello prognostico impiegando età, Stadio, BT, LVI e immunofenotipo; tale modello ha mostrato gli indici di performance migliori. I risultati ottenuti suggeriscono che questo modello prognostico è un sistema semplice, economico e pratico per la valutazione degli OTSCC. Tuttavia sono necessari ulteriori studi di validazione su coorti più ampie.<br>The oral tongue squamous cell carcinoma (OTSCC) is characterized by a high rate of recurrence and a stable mortality rate in the last 20 years. The 8th edition of AJCC staging system has allowed for better stratification of patients with OTSCC. However, the predictive capability of this system still need to be improved in order to better stratify those patients with a more aggressive disease, searching for new prognostic markers. The aim of this study was to investigate the main morphological features of tumor tissue and to develop a prognostic model and a nomogram, in order to improve the stratification of OTSCC patients. A retrospective cohort study on 211 OTSCC patients has been conducted. Several histopathological parameters have been visually assessed on 4-μm hematoxylin-eosin stained sections: pattern of invasion (POI), perineural invasion (PNI), lymphovascular invasion (LVI), tumor budding (BT), tumor associated tissue eosinophilia (TATE), tumor stroma ratio (TSR), and the immune phenotype. The primary endpoints were the disease-specific survival (DSS) and the disease-free survival (DFS). Univariate Cox analysis highlighted significant associations between a reduced DSS and: advanced Stage (p<0,001), multifocal PNI (p<0,001), peritumoral PNI (p=0,003), LVI (p<0,001), BT (p<0,001), low TATE (p<0,001), low TSR (p<0,001) and desert immune phenotype (p<0,001). The multivariate analysis and the stepwise regression analysis were conducted in order to create a prognostic model and a nomogram for DSS evaluation. Age, Stage, BT, LVI, and immune phenotype were entered into the model, showing the best performance. The results obtained suggest that the prognostic model is simple, inexpensive, and practical system for the evaluation of OTSCC. However, further validation studies on larger cohorts are needed.
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Sgaramella, Nicola. "Squamous cell carcinoma of the oral tongue : studies of biomarkers connected to human papillomavirus infection, epithelial to mesenchymal transition and locoregional metastatis." Doctoral thesis, Umeå universitet, Patologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134567.
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Background: Oral Tongue Squamous Cell Carcinoma (OTSCC) is the most frequent and aggressive carcinoma in the head and neck region. Its incidence has increased during the last decades, especially in young patients (≤40 years) mainly female. These young patients have either not been exposed to the traditional risk factors for this disease, or have a much reduced duration of exposure than the typical OTSCC patient. The reasons behind this increasing incidence remain unknown. The aims of this thesis were to analyse the presence and possible role of human papillomavirus (HPV) in oral tongue cancer in correlation with its surrogate marker p16 and its receptor syndecan-1. Other aims were to evaluate expression of EMT (epithelial to mesenchymal transition) - related markers, such as E-cadherin, β-catenin, CK5 and CK19, and to address the potential predictive role of podoplanin in the loco-regional metastatic process. Clinical parameters including age, sex, geographical distribution, relapse, tumour staging and grading were also investigated for a possible correlation with biomarker expression and prediction of survival rate and therapeutic strategy. Materials and methods: More than one hundred samples of OTSCC coming from two University Hospitals of two different countries (Sweden and Italy) were analysed. HPV presence was evaluated by in situ hybridisation for detection of the high-risk HPV 16 and indirectly by immunohistochemistry (IHC) of its surrogate marker p16. Expression of the HPV receptor syndecan-1 and the EMT biomarkers E-cadherin, β-catenin, CK5, CK19 were also evaluated by immunohistochemistry. Samples were scored using a quick score (QS), taking both number and intensity of cells stained into account. Podoplanin expression was investigated at both protein and RNA level. Results: Tumour size and lymph node metastasis correlated to both overall and disease-free survival. Despite variable expression of the syndecan-1 receptor, HPV 16 was not detected in any sample analysed, excluding a possible association with p16, which was expressed in 33% of the cases. All EMT-related markers were commonly expressed in tongue cancer. Data showed E-cadherin to be an independent prognostic factor with higher expression associated with poor overall survival. Notably, E-cadherin, β-catenin and CK5 directly correlated to each other. Multivariate analysis of clinical data demonstrated that age of the patient is an independent prognostic factor with younger patients showing a worse survival rate. Patients younger than 40 years also showed significantly higher expression of podoplanin. Data for geographic distribution revealed a difference in expression of E-cadherin between Swedish and Italian patients. Conclusions: In contrast to SCC of the base of the tongue and the tonsil, HPV is not present in OTSCC, excluding HPV infection as a risk factor. Higher levels of E-cadherin and young age is associated with poor survival in OTSCC patients. The different frequency of EMT markers seen between Swedish and Italian patients suggests an important role for the environment and the geographical area in the onset of different molecular patterns of OTSCC.
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Jonsson, Eva Lindell. "Biomolecular markers in head and neck cancer." Doctoral thesis, Uppsala universitet, Öron-, näs- och halssjukdomar, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306126.
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Head and neck cancer is a heterogeneous group of tumours, of which certain subgroups such as cancer of the mobile tongue frequently are associated with a relatively poor prognosis due to the high risk of regional failure and mortality rates that haven’t improved in a significant way over the last 3 decades, despite advancements in both diagnostics and treatment. Today we lack means to assess the biological aggressiveness of each individual tumour, which varies largely. Treatment comprises of surgery with additional radiotherapy and medical therapies in more advanced tumours. The focus in this thesis is on molecular biomarker expression in head and neck cancer and especially in association with radiotherapy. Increased knowledge paves the way to a more individualized cancer treatment aiming for better outcome and less overtreatment and sequelae. The aims of this thesis was: To map the effects of radiotherapy in both tumour and adjacent tissue for the possible markers hyaluronan, EGFR and mast cells. To investigate whether the expression of hyaluronan in the epithelium and connective tissue stroma and EGFR in the tumour correlates with the risk for developing cervical metastasis in N0 patients, and to find out whether the 3-year tumour-specific survival rates correlates with the expression of HA in the epithelium and EGFR in the tumour. To establish an animal model for radiation-induced mucositis and to use that model to examine the pattern of invading inflammatory cells. To investigate whether the expression of podoplanin in tongue cancer correlates with the risk for cervical metastasis and to determine whether the total amount of lymph vessels in the diagnostic biopsy has any impact on the clinical outcome. To investigate the differences in the metabolome of tongue cancer cell lines with different radiosensitivity. The most important findings of this thesis were: The expression of EGFR and hyaluronan hade the same pattern of expression in both tumour and adjacent tissues before radiotherapy. The expression of EGFR was increased in the epithelium of the adjacent tissue close to the tumour after radiotherapy. The intensity of the staining of hyaluronan was correlated to the 3-year survival rates in patients with tongue cancer. An experimental model for radiation-induced oral mucositis in rat was established and in this model a temporal pattern of macrophage invasion with two different subtypes of macrophages was found. There were no correlation between the expression of podoplanin in the tumour tissue and the cervical metastasis rate in patients with tongue cancer, but the younger patients were more likely to have a higher expression of podoplanin in their tumour than elder patients. Tongue cancer cell lines with different radiosensitivity respond to irradiation with different patterns of metabolic expressions.
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Nascimento, George Jo?o Ferreira do. "Associa??o entre polimorfismos funcionais nos genes da MMP-7 e MMP-9 e o perfil clinicopatol?gico do carcinoma epiderm?ide de l?ngua." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17145.
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Previous issue date: 2010-02-18<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) modulate important functions strictly related to the development, invasion and metastasis of several human cancers among them the squamous cell carcinoma of the tongue (SCCT). However, individual genetic factors such as the functional single nucleotide polymorphisms (SNPs) influence the pattern of protein expression of these MMPs and thus may be related to the variability observed in the clinical behavior of patients with SCCT. In this context, the present cross-sectional study aimed to evaluate the association between the frequency of the functional SNPs MMP-7 -181 A/G and MMP-9 -1562 C/T and the clinical (age, gender and metastasis) and pathological (malignancy histological grading and immunohistochemistry expression) features of SCCT cases. Genotyping of these SNPs were performed by PCR-RFLP on DNA samples from 71 cases of SCCT and 60 individuals without cancer who constitute the control group. Among the results of this research, it was observed that the frequency of the polymorphic alleles MMP-7 -181 G and MMP-9 -1562 T in SCCT patients was 28% and 12%, respectively, and the frequency of the heterozygotes A/G (PR = 2.00; p < 0.001) and C/T (PR = 1.54; p = 0.014) were significantly higher in the patient group than in the controls. The prevalence of patients carrying the combination of SNPs studied was significantly associated with SCCT cases (PR = 2.00; p = 0.011) and metastasis (PR = 2.00; p < 0.001). Furthermore, with the frequency of SNPs analyzed, the age, gender, histological grading and immunoreactivity of MMP-7 and MMP-9 formed clinical and pathological parameters relevant to the identification of population subgroups more related to the development of SCCT and metastasis. Based on these results, it is suggested that the protein expression levels of MMP-7 and -9 substantially influence the balance between their pro- and anticancer biological functions and hence the clinicopathological profile of the squamous cell carcinoma of the tongue<br>As metaloproteinases da matriz extracelular-7 (MMP-7) e -9 (MMP-9) modulam importantes fun??es relacionadas ao desenvolvimento, invas?o e met?stase de diversos c?nceres humanos, dentre os quais o carcinoma epiderm?ide de l?ngua (CEL). Entretanto, fatores gen?ticos individuais, tais como polimorfismos de nucleot?deo ?nico (SNPs) funcionais, influenciam no padr?o de express?o proteica dessas MMPs, podendo estar relacionados ? variabilidade no comportamento cl?nico tumoral observado em pacientes com CEL. Neste contexto, o presente trabalho objetivou, atrav?s de an?lise em sec??o transversal, estudar a associa??o entre a frequ?ncia dos SNPs funcionais MMP-7 -181 A/G e MMP-9 -1562 C/T e as caracter?sticas cl?nicas (idade, sexo e met?stase) e patol?gicas (grada??o histol?gica e express?o imuno-histoqu?mica) em uma s?rie de casos de CEL. A genotipagem dos referidos SNPs foi executada por PCR-RFLP em amostras de DNA de 71 casos de CEL e de 60 indiv?duos sem c?ncer, que constitu?ram o grupo controle. Dentre os resultados da presente pesquisa, evidenciou-se que a frequ?ncia dos alelos polim?rficos MMP-7 -181 G e MMP-9 -1562 T nos pacientes com CEL foi de 28% e 12%, respectivamente, sendo as frequ?ncias dos heterozigotos A/G (RP = 2.00; p < 0.001) e C/T (RP = 1.54; p = 0.014) significativamente maiores neste grupo de pacientes que no grupo controle. A preval?ncia dos pacientes portadores da combina??o dos SNPs estudados associou-se significativamente aos casos de CEL (RP = 2.00; p = 0.011) e ? met?stase (RP = 2.00; p < 0.001). Ademais, junto ? frequ?ncia dos SNPs analisados, a idade, sexo, grada??o histol?gica e imunoexpress?o da MMP-7 e -9 constitu?ram par?metros clinicopatol?gicos relevantes para a identifica??o de subgrupos populacionais mais predispostos ao desenvolvimento do CEL e met?stase. Frente a estes resultados, sugere-se que os n?veis de express?o da MMP-7 e -9 influenciam consideravelmente no balan?o entre suas fun??es pr? e antineopl?sicas e, consequentemente, no perfil clinicopatol?gico do carcinoma epiderm?ide de l?ngua.
Books on the topic "Oral Tongue Cancer"
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Rider, Jennifer R., Paul Brennan, and Pagona Lagiou. Oral and Pharyngeal Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190676827.003.0007.
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This chapter covers cancer of the oral cavity and the oropharynx, which includes the base of the tongue, soft palate, tonsils, and back and side walls of the throat. Many important risk factors for oral and oropharyngeal cancer have been identified, and in 2007 the World Health Organization determined there was sufficient evidence to include human papilloma virus (HPV) type 16 as a cause of these cancers. Tobacco and alcohol remain important modifiable risk factors, but the increasing incidence of HPV-associated tumors is now evident. While these tumors are more amenable to treatment than HPV-negative tumors, they are still a source of considerable morbidity and mortality. Moreover, the lack of a precursor lesion and limited data on efficacy of the HPV vaccine in preventing oral HPV infection are barriers to primary and secondary prevention efforts. Dietary patterns high in fruits and vegetables and low in meats may confer some protection.
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Hashibe, Mia, Erich M. Sturgis, Jacques Ferlay, and Deborah M. Winn. Oral Cavity, Oropharynx, Lip, and Salivary Glands. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0029.
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Cancers of the oral cavity, oropharynx, lip, and salivary glands are malignancies of the head and neck. Some of these cancer sites share risk factors, although each has distinctive anatomic, epidemiologic, and clinical features. Oral cavity cancers arise on the inner lip and buccal mucosa, anterior two-thirds of the tongue, gum, hard palate, and floor of mouth. These cancers are strongly associated with the use of smoked and smokeless tobacco products, heavy alcohol consumption, and chewing of betel quid or pan, but only minimally associated with prior infection with human papillomavirus (HPV). In contrast, oropharyngeal cancers affect the posterior one-third (base) of the tongue, tonsils, soft palate, and other oropharyngeal tissues and are strongly associated with HPV-16 infection as well as with the use of tobacco, alcohol, and betel quid. In principle, tumors of the oral cavity, oropharynx, and lip are among the most preventable forms of cancer.
Book chapters on the topic "Oral Tongue Cancer"
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Haribhakti, Vijay V. "Oral Tongue and Floor Mouth." In Restoration, Reconstruction and Rehabilitation in Head and Neck Cancer. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-2736-0_13.
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Ramanathan, Anand, Siti Mazlipah Ismail, and Harsha Lal De Silva. "Non-healing Ulcer in the Right Lateral Surface of the Tongue: Oral Cancer." In Clinicopathological Correlation of Oral Diseases. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-24408-7_25.
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Bahadur, Sudhir. "Guidelines in Management of Carcinoma of the Tongue and Floor of Mouth." In Management of Oral Cancers. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6499-4_10.
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Jani, Khyati, Deepak Balasubramanian, Krishnakumar Thankappan, and Subramania Iyer. "Reconstruction of Soft Tissue Defects of Buccal Mucosa and Tongue: Choice of Flap." In Management of Oral Cancers. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6499-4_13.
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"16 Reconstruction of the Oral TongueTongue (oral tongue) reconstructionReconstructionoral tongue." In Oral Cancer, edited by Carole Fakhry, Karen T. Pitman, Ana P. Kiess, and David W. Eisele. Georg Thieme Verlag, 2020. http://dx.doi.org/10.1055/b-0040-176902.
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Shiga, Kiyoto, Katsunori Katagiri, Ayako Nakanome, Takenori Ogawa, and Toshimitsu Kobayashi. "Management of Early-Stage Tongue Cancer." In Oral Cancer. InTech, 2012. http://dx.doi.org/10.5772/31895.
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Lubek, Joshua E., Donita Dyalram, Mohan Suntharalingam, and Robert A. Ord. "Early Tongue Cancer." In Oral, Head and Neck Oncology and Reconstructive Surgery. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-323-26568-3.00018-x.
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Smart, Ryan J., Dongsoo David Kim, and G. E. Ghali. "Advanced Tongue Cancer." In Oral, Head and Neck Oncology and Reconstructive Surgery. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-323-26568-3.00019-1.
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Xiao, Xue, and Zhou Wang. "Oral Cancer." In Pharynx - Diagnosis and Treatment. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97330.
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Oral cancer is a frequent head and neck cancer in developing countries and some developed world. According to the World Health Organization classification 2017, oral cancer influences the anatomical subsites including buccal mucosa, the anterior two-third of the tongue, lip, palate, vestibule, alveolus, floor of the mouth, and gingivae. A variety of premalignant lesions are related with the development of oral cancer, such as leukoplakia, erythroplakia, et al. The predominant histological type of oral cancer is squamous cell carcinoma (SCC). Tobacco and alcohol consumption are regarded as critical etiological factors. Due to the unspecific symptoms in early stage, the majority are diagnosed in advanced stages. Despite the development of medicine over decades, the mortality rate of oral cancer remains high, indicating the importance of optimized treatment and screening strategies.
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Daly, Blánaid, Paul Batchelor, Elizabeth Treasure, and Richard Watt. "Oral cancer prevention." In Essential Dental Public Health. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199679379.003.0020.
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Oral cancer is one of the few conditions that dental professionals may encounter within their surgeries that can be fatal. It is therefore essential that members of the dental team understand the epidemiology and natural history of the condition and possible options for prevention, screening, and treatment. From a public health perspective, oral cancer presents many interesting challenges. First, is the condition a public health problem? In this chapter the epidemiology of oral cancer will be reviewed to highlight the extent, trends, and impact of the condition. Second, what options exist to prevent the disease and how best can these be implemented? As we will discuss, although progress has been made in the treatment of the disease, survival rates have not improved substantially in recent decades (Cancer Research UK 2012; ONS 2005; Stell and McCormick 1985). The potential for screening of the condition has been extensively reviewed, and currently a national screening programme is not recommended due to a lack of evidence on effectiveness (Chamberlain 1993). Although various initiatives have recently attempted to coordinate and expand the prevention of oral cancer (Cancer Research UK 2005; British Dental Association 2000; NHS Scotland 2005), the preventive activities presently undertaken by the dental profession alone are unlikely to be successful. A clear need exists for a more comprehensive public health strategy to tackle the underlying causes of the disease in a coordinated and strategic fashion. This chapter will therefore outline the scope and detail of such a strategy. Oral and oropharngeal cancers commonly include cancer of the lip, tongue, mouth, oropharynx, piriform sinus, hypopharynx, and other ill-defined sites of the lip, oral cavity, and pharynx (ICD-10, C00–C06, C09– C10, and C12–C14). In the UK, oral cancer is the fifteenth most common cancer, accounting for around 2% of all new cases. In 2009 there were 6,236 new cases of oral cancer in the UK: 4,097 (66%) in men and 2,139 (34%) in women (Cancer Research UK 2012 ). The most commonly diagnosed type of oral cancers are cancer of the mouth and tongue, collectively accounting for 60% of cases in the UK.
Conference papers on the topic "Oral Tongue Cancer"
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Varvares, Mark, Meredith August, Tayyaba Hasan, and Srivalleesha Mallidi. "Surgical navigation in oral tongue cancer resections (Conference Presentation)." In 17th International Photodynamic Association World Congress, edited by Tayyaba Hasan. SPIE, 2019. http://dx.doi.org/10.1117/12.2528072.
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Won, Natalie, Josephine La Macchia, Anjola Adewale, et al. "Quantitative Spatial Frequency Domain Fluorescence Imaging for Surgical Guidance: Fluorophore Concentration Estimation in Pre-Clinical Cancer Models." In Optical Molecular Probes, Imaging and Drug Delivery. Optica Publishing Group, 2023. http://dx.doi.org/10.1364/omp.2023.oth1e.1.
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Image quantification of fluorophore concentration based on phase-shifted sinusoidal patterns projected onto the surgical field. Results analyzed in an oral cancer mouse model and optical phantoms derived from tongue cancer patients.
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Vasquez, Sarah, Thomas Lipkin, Dana Landry, et al. "Investigating the Use of Magnetic Actuation for a Self-Contained Functional Tongue Prosthetic." In ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-69641.
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Abstract Oral cancer can result in the loss of the tongue through surgical removal known as glossectomy. Patients who have undergone this procedure face challenges during speech, mastication, and deglutition. Currently, tongue prosthetics lack functionality and are mainly cosmetic. Many of these prosthetics are made of wax and connected to a retainer, which attaches to the back molars of the patient. The goal of this project was to develop a self-contained mechatronic tongue prosthesis that can fit within the oral cavity and aid in deglutition. Investigations into various techniques and sensors supporting miniaturization were carried out and magnetic actuation was found to be the most promising technique. The development process involved redesigning the silicone cast to house sensors, selecting sensors and components for magnetic actuation, magnetic field quantification and miniaturizing various other electrical components. The tongue prosthesis was tested, and the displacement was comparable to a normal human tongue. Details from literature review, design iterations, simulations, validation processes, manufacturing challenges and conclusions will be discussed in depth in this paper.
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Dos Santos, Dalí, Adriano Silva, Paulo De Faria, Bruno Travençolo, and Marcelo Do Nascimento. "Impacts of Color Space Transformations on Dysplastic Nuclei Segmentation Using CNN." In Workshop de Visão Computacional. Sociedade Brasileira de Computação - SBC, 2020. http://dx.doi.org/10.5753/wvc.2020.13475.
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Oral epithelial dysplasia is a common precancerous lesion type that can be graded as mild, moderate and severe. Although not all oral epithelial dysplasia become cancer over time, this premalignant condition has a significant rate of progressing to cancer and the early treatment has been shown to be considerably more successful. The diagnosis and distinctions between mild, moderate, and severe grades are made by pathologists through a complex and time-consuming process where some cytological features, including nuclear shape, are analysed. The use of computer-aided diagnosis can be applied as a tool to aid and enhance the pathologist decisions. Recently, deep learning based methods are earning more and more attention and have been successfully applied to nuclei segmentation problems in several scenarios. In this paper, we evaluated the impact of different color spaces transformations for automated nuclei segmentation on histological images of oral dysplastic tissues using fully convolutional neural networks (CNN). The CNN were trained using different color spaces from a dataset of tongue images from mice diagnosed with oral epithelial dysplasia. The CIE L*a*b* color space transformation achieved the best averaged accuracy over all analyzed color space configurations (88.2%). The results show that the chrominance information, or the color values, does not play the most significant role for nuclei segmentation purpose on a mice tongue histopathological images dataset.
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Holod, Ace, Nadia Singh, Xavier Curney, Pradeep Radhakrishnan, and Kaveh Pahlavan. "Design and Experiments Involving a Mechanism-Based Artificial Tongue Prosthesis." In ASME 2023 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/imece2023-113831.
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Abstract Oral cancer can result in the loss of tongue through total glossectomy, and patients have difficulty with speech, deglutition, and mastication. Current tongue prostheses lack the ability to move for mastication and deglutition and are mainly for cosmetic purposes. The goal of this research was to investigate and develop a self-contained prosthetic tongue that could aid in deglutition by moving bolus from the front of the mouth to the back. A review of existing designs and alternatives led to the development of a linkage system mounted in a silicone cast to move the bolus. The development of this new prosthetic tongue design entailed creating silicone molds, 3D printing linkage systems and jaws, and developing new circuits. The circuit used a TinyDuino microcontroller and MOSFET. A functional mandibular Hawley retainer was added to hold the tongue to increase ease of use. The final circuit used an EMG sensor to trigger actuation and a single servo motor with a gear train to actuate the tongue. The prosthetic tongue succeeded in moving bolus from the front of the mouth to the back when lying at a 5-degree angle and actuating between 1.8–2.31cm in height. The paper will describe the development process, challenges, and future work.
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Adduri, Raju SR, Padmavathi Kavadipula, Viswakalyan Kotapalli, et al. "Abstract 3692: Transcriptome analysis of oral tongue cancer reveals novel insights into wild type and mutant TP53 transcription program." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3692.
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Hua, Tzu-En, Ko-Jiunn Liu, and Shiue-Cheng Tang. "Abstract 716: 3-D imaging and illustration of nerve-lesion association in the mouse tongue of experimental oral cancer." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-716.
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Dwivedi, Karnika, Kumud Patel, Jai Prakash Pandey, and Preeti Garg. "An Automatic Robust Deep Learning and Feature Fusion-based Classification Method for Early Diagnosis of Oral Cancer Using Lip and Tongue Images." In 2024 2nd International Conference on Disruptive Technologies (ICDT). IEEE, 2024. http://dx.doi.org/10.1109/icdt61202.2024.10489266.
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Tran, Emily, Anne Hellebust, Jean Wu, Ann Gillenwater, Nadarajah Vigneswaran, and Rebecca R. Richards-Kortum. "Optically Cleared Mouse Tongues for Three-Dimensional Investigation of Oral Neoplasia." In Cancer Imaging and Therapy. OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.jm3a.50.
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Siagian, Karina Witary Ayu, Benny Kurnia, and Fadhlia Fadhlia. "Hemiglossectomy with Supraomohyoid Neck Dissection on T3N1M0 Tongue Cancer Patient." In 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021). Atlantis Press, 2021. http://dx.doi.org/10.2991/ahsr.k.220206.036.
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