Relevant bibliographies by topics / Oral Tongue Squamous Cell Carcinoma

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Academic literature on the topic 'Oral Tongue Squamous Cell Carcinoma'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Oral Tongue Squamous Cell Carcinoma"

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Maxwell, Jessica H., Lester D. R. Thompson, Margaret S. Brandwein-Gensler, Bernhard G. Weiss, Martin Canis, Bibianna Purgina, Arpan V. Prabhu, et al. "Early Oral Tongue Squamous Cell Carcinoma." JAMA Otolaryngology–Head & Neck Surgery 141, no. 12 (December 1, 2015): 1104. http://dx.doi.org/10.1001/jamaoto.2015.1351.

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Su, Yan-Ye, Chang-Han Chen, Chih-Yen Chien, Wei-Che Lin, Wan-Ting Huang, and Shau-Hsuan Li. "Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma." Journal of the Renin-Angiotensin-Aldosterone System 18, no. 3 (July 2017): 147032031771790. http://dx.doi.org/10.1177/1470320317717904.

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Introduction: Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. However, the role of the mitochondrial assembly receptor in the prognosis of cancer patients remains unclear. The aim of this study was to evaluate the significance of mitochondrial assembly receptor signaling in the prognosis of oral tongue squamous cell carcinoma. Methods: Mitochondrial assembly receptor immunohistochemistry was examined in 151 oral tongue squamous cell carcinoma patients and was correlated with treatment outcome. The functional relevance of the mitochondrial assembly receptor in oral tongue squamous cell carcinoma cell lines was evaluated by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide reduction and bromodeoxyuridine incorporation assays. Results: Mitochondrial assembly receptor overexpression was significantly correlated with early pathological T classification ( p=0.029) and the absence of extracapsular spread ( p=0.039). Univariate analyses demonstrated that mitochondrial assembly receptor overexpression was significantly associated with superior overall survival ( p=0.012). In multivariate comparison, mitochondrial assembly receptor overexpression remained independently associated with superior overall survival ( p=0.008, hazard ratio=1.862). In vitro, angiotensin-(1-7) suppressed the cell growth in oral tongue squamous cell carcinoma cells, and this response was reversed by the mitochondrial assembly receptor antagonist, A779. Conclusion: Mitochondrial assembly receptor expression is independently associated with the prognosis of oral tongue squamous cell carcinoma patients. These findings suggest that mitochondrial assembly receptor signaling may be a promising novel target for oral tongue squamous cell carcinoma.
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Hainarosie, Razvan, Viorel Zainea, Mura Hainarosie, Catalina Pietrosanu, Irina Ionita, Silviu Pituru, and Dragos Cristian Stefanescu. "Methylene Blue Test in Assessing Disease Free Margins in Lingual Carcinoma Resection." Revista de Chimie 68, no. 12 (January 15, 2018): 2879–80. http://dx.doi.org/10.37358/rc.17.12.5998.

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Lingual squamous cell carcinoma is one of the most frequent localization of the oral carcinomas. The tongue neoplasia represents nearly 40% of the oral carcinomas. Recent studies showed an increasing trend of lingual carcinoma in young patients. Several staining tests have been described to early detect the disease. After detection, disease free margins resection will increase the survival rate. This study aims to analyze the methylene blue staining test in achieving disease free resection margins in lingual squamous cell carcinoma.
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P Ingle, Paramita, Basavaraj T Bhagawati, Pritam S Pohankar, and Meenal S Jethlia. "Oral Squamous Cell Carcinoma of Tongue - Case Report." Acta Scientific Dental Scienecs 4, no. 8 (July 23, 2020): 117–27. http://dx.doi.org/10.31080/asds.2020.04.0894.

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Durr, Megan L., Annemieke van Zante, David Li, Eric J. Kezirian, and Steven J. Wang. "Oral Tongue Squamous Cell Carcinoma in Never-Smokers." Otolaryngology–Head and Neck Surgery 149, no. 1 (March 26, 2013): 89–96. http://dx.doi.org/10.1177/0194599813482876.

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Nurrahman, Tri, Seto Adiantoro, Kiki Akhmad Rizki, and Farah Asnely. "MULTIDISCIPLINARY APPROACH IN THE TREATMENT OF SQUAMOUS CELL CARCINOMA AT REGIO GLOSSUS." Dentino : Jurnal Kedokteran Gigi 5, no. 2 (August 15, 2020): 205. http://dx.doi.org/10.20527/dentino.v5i2.8976.

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ABSTRACTBackground: Squamous Cell Carcinoma (SCC) is the most common case of oral cancer which often occurs laterally on the tongue and rarely develops on the dorsal surface of the tongue. More than half of the cases are diagnosed late, thereby reducing the survival rate of the patients. Objective: This report was intended as an evaluation for the management of squamous cell carcinoma under multidisciplinary approach between oral surgery and other departments, as well as the provision of further post-operative treatment. Case Report: The author presents a case of 68-years-old female patient with a lump and an ulcer on her tongue. Around six months prior to the visit, patient complained of tongue ulcer followed by the emergence of a lump in a size of a corn seed. The lump was gradually enlarged with constant widening of the ulcer. Pain on the tongue was also perceived. The patient was then referred to Hasan Sadikin Hospital for further treatment. Case Management: Patients underwent hemiglossectomy and Selective Neck Dissection (SND) surgical procedures performed by Oral and Maxillofacial Surgeon in collaboration with Surgical Oncologist. Furthermore, after surgery, the patient was consulted to the Hemato-Oncology Division of Internal Medicine Department for chemotherapy treatment. Conclusions: The exact diagnosis was made based on the histopathological biopsy results of the tongue tissue. Management of tongue cancer must be done multidisciplinary. Some things that must be considered in handling such cases are the eradication of the tumor, the return of oral cavity function, and the aesthetic/functional aspects of the patient. Keywords: Oral cancer, Squamous cell carcinoma, Tongue cancer
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Caponio, Troiano, Mascitti, Santarelli, Mauceri, and Lo Muzio. "Predicting Death in Patients with Squamous Cell Carcinoma of the Tongue." Proceedings 35, no. 1 (December 10, 2019): 18. http://dx.doi.org/10.3390/proceedings2019035018.

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Tongue squamous cell carcinoma (TSCC) accounts for 40% of all squamous cell carcinoma involving the mucosal surface of the oral cavity. TSCC is highly invasive and aggressive and, nowadays, TNM staging system is considered the gold standard in predicting patients’ outcomes. [...]
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KUROKAWA, Hideo, Yoshihiro YAMASHITA, Keiko MIURA, Shingo TOKUDOME, and Minoru KAJIYAMA. "Clinicopathological evaluation of oral squamous cell carcinomas. Highly invasive tongue carcinoma." Japanese Journal of Oral & Maxillofacial Surgery 45, no. 5 (1999): 324–28. http://dx.doi.org/10.5794/jjoms.45.324.

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Ryott, Michael, Linda Marklund, Darawalee Wangsa, Göran Elmberger, and Eva Munck-Wikland. "Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma." Journal of Oral Pathology & Medicine 40, no. 5 (April 12, 2011): 385–89. http://dx.doi.org/10.1111/j.1600-0714.2010.00992.x.

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Sano, Daisuke, and Jeffrey N. Myers. "Metastasis of squamous cell carcinoma of the oral tongue." Cancer and Metastasis Reviews 26, no. 3-4 (September 3, 2007): 645–62. http://dx.doi.org/10.1007/s10555-007-9082-y.

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Dissertations / Theses on the topic "Oral Tongue Squamous Cell Carcinoma"

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Åström, P. (Pirjo). "Regulatory mechanisms mediating matrix metalloproteinase-8 effects in oral tissue repair and tongue cancer." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526206103.

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Abstract Tissue repair and cancer progression involve similar mechanisms, including degradation of extracellular matrix in which matrix metalloproteinases (MMPs) play essential roles. The action of MMPs is important in normal physiological processes but MMPs also contribute to various pathological conditions. MMP-8 belongs to a family of collagenases with a diverse set of substrates. MMP-8 action is involved in skin wound healing and in various human cancers. The function of MMP-8 in cancer appears to be highly complex and varies depending on the cancer type and location. Little is known about the involvement of MMP-8 in oral physiology and pathology. The aim of this study was to clarify the role of MMP-8 in oral tissue repair and oral tongue squamous cell carcinoma (OTSCC). Studies with MMP-8 deficient mice revealed that the function of MMP-8 in tissue repair is highly dependent on the spatial aspects. In alveolar bone, MMP-8 increased inflammation and affected collagen metabolism. In tongue wounds, MMP-8 impaired early healing and reduced transforming growth factor (TGF) -β1 levels. This study also revealed the protective role of MMP-8 in OTSCC patients, in agreement with previous studies indicating positive features of MMP-8 in cancer. Low MMP-8 level and high vascular endothelial growth factor (VEGF) -C levels in tumors correlated with worse prognosis in these patients. In mouse tongue fibroblast cell cultures, MMP-8 reduced TGF-β1 signaling molecule phosphorylated Smad2 levels and impaired the collagen contraction ability. TGF-β1, apoptosis factor Fas-ligand (Fas-L) and estrogen receptors (ERs) were identified as novel MMP-8 substrates. In OTSCC cell cultures, MMP-8 impaired cell migration and invasion. Diminished TGF-β1 levels were involved in the defective migration of MMP-8 overexpressing cells. Moreover, MMP-8 affected the expression of MMP-9, MMP-1, cathepsin-K, VEGF-C and TGF-β1. In mouse models of OTSCC, MMP-8 protected against tumor development but was not able to prevent metastasis formation. The main findings of this study were that 1) MMP-8 action in tissue repair depends on the site of the injury and 2) in OTSCC, MMP-8 has tumor suppressive effects, but in mouse, MMP-8 does not inhibit metastasis formation. In addition, 3) four novel MMP-8 substrates (TGF-β1, Fas-L, ER-α and -β) were identified that may explain the spatial and diverse roles of MMP-8
Tiivistelmä Kudosvaurioiden paranemiseen ja syövän etenemiseen liittyy useita samankaltaisia mekanismeja. Molemmissa toimivat soluvälitilan muokkaamiseen osallistuvat proteaasit, joista matriksin metalloproteinaaseilla (MMP) on tärkeä merkitys; ne osallistuvat lukuisiin elimistön keskeisiin fysiopatologisiin prosesseihin. Kollagenaasi MMP-8 muokkaa monentyyppisiä molekyylejä. Se on mukana ihohaavan paranemisessa ja useissa syövissä. MMP-8:n toiminta syöpätiloissa on hyvin moninainen riippuen syöpätyypistä ja sijainnista. Väitöstutkimuksessa selvitettiin MMP-8:n merkitystä suun kova- ja pehmytkudosvaurioprosesseissa sekä kielisyövässä, joissa se on ollut tuntematon. MMP-8 poistogeenisillä hiirillä tehdyissä pehmyt- ja kovakudoshaavoissa MMP-8:n vaikutusmekanismit riippuivat kohdekudoksesta. Alveoliluun paranemisen yhteydessä MMP-8 lisäsi tulehdusta ja osallistui kollageenin muokkaamiseen. Akuutin kielihaavan paranemisessa MMP-8 hidasti haavan umpeutumista ja vähensi transformoivan kasvutekijä-β1:n (TGF-β1) määrää. Kuten useissa muissakin syövissä, myös kielisyövässä todettiin MMP-8:lla olevan suojaava vaikutus. Potilaan ennuste huononi, jos kasvainsolukon matala MMP-8-taso yhdistyi korkeaan verisuonten kasvutekijä-C:n (VEGF-C) määrään. Hiiren kielen normaaleissa fibroblastiviljelmissä MMP-8 vähensi TGF-β1:n solunsisäistä signalointia välittävän fosforyloidun Smad2:n määrää sekä solujen kykyä supistaa kollageenikiekkoja. Koeputkessa MMP-8 pilkkoi TGF-β1:tä, estrogeenireseptoreja (ER) ja apoptoositekijä Fas-ligandia (Fas-L). Ihmisen kielikarsinoomasoluviljelmissä korkea MMP-8:n määrä vähensi solujen migraatiota ja invaasiota sekä muutti MMP-1:n, MMP-9:n, katepsiini-K:n, TGF-β1:n ja VEGF-C:n ilmentymistä. Migraation heikentyminen MMP-8:aa tuottavissa soluissa johtui osin vähentyneestä TGF-β1:n määrästä. Hiiren kokeellisissa kielisyövissä MMP-8 hidasti syövän muodostumista mutta ei estänyt etäpesäkkeiden muodostusta. Tässä väitöskirjatutkimuksessa on kolme päälöydöstä: 1) MMP-8:n vaikutus kudoksen paranemisprosessiin riippuu vauriokohdasta, 2) MMP-8 on kielisyövän kehittymisessä puolustuksellinen molekyyli, mutta sen lisääntynyt tuotto ei hiirikokeissa estänyt etäpesäkkeiden muodostusta, 3) MMP-8:lle löydettiin neljä uutta kohdemolekyyliä (TGF-β1, Fas-L, ER-α ja -β), joiden muokkaus saattaa osin selittää MMP-8:n monipuoliset kudos- ja prosessispesifit vaikutukset
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Sgaramella, Nicola. "Squamous cell carcinoma of the oral tongue : studies of biomarkers connected to human papillomavirus infection, epithelial to mesenchymal transition and locoregional metastatis." Doctoral thesis, Umeå universitet, Patologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134567.

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Background: Oral Tongue Squamous Cell Carcinoma (OTSCC) is the most frequent and aggressive carcinoma in the head and neck region. Its incidence has increased during the last decades, especially in young patients (≤40 years) mainly female. These young patients have either not been exposed to the traditional risk factors for this disease, or have a much reduced duration of exposure than the typical OTSCC patient. The reasons behind this increasing incidence remain unknown. The aims of this thesis were to analyse the presence and possible role of human papillomavirus (HPV) in oral tongue cancer in correlation with its surrogate marker p16 and its receptor syndecan-1. Other aims were to evaluate expression of EMT (epithelial to mesenchymal transition) - related markers, such as E-cadherin, β-catenin, CK5 and CK19, and to address the potential predictive role of podoplanin in the loco-regional metastatic process. Clinical parameters including age, sex, geographical distribution, relapse, tumour staging and grading were also investigated for a possible correlation with biomarker expression and prediction of survival rate and therapeutic strategy. Materials and methods: More than one hundred samples of OTSCC coming from two University Hospitals of two different countries (Sweden and Italy) were analysed. HPV presence was evaluated by in situ hybridisation for detection of the high-risk HPV 16 and indirectly by immunohistochemistry (IHC) of its surrogate marker p16. Expression of the HPV receptor syndecan-1 and the EMT biomarkers E-cadherin, β-catenin, CK5, CK19 were also evaluated by immunohistochemistry. Samples were scored using a quick score (QS), taking both number and intensity of cells stained into account. Podoplanin expression was investigated at both protein and RNA level. Results: Tumour size and lymph node metastasis correlated to both overall and disease-free survival. Despite variable expression of the syndecan-1 receptor, HPV 16 was not detected in any sample analysed, excluding a possible association with p16, which was expressed in 33% of the cases. All EMT-related markers were commonly expressed in tongue cancer. Data showed E-cadherin to be an independent prognostic factor with higher expression associated with poor overall survival. Notably, E-cadherin, β-catenin and CK5 directly correlated to each other. Multivariate analysis of clinical data demonstrated that age of the patient is an independent prognostic factor with younger patients showing a worse survival rate. Patients younger than 40 years also showed significantly higher expression of podoplanin. Data for geographic distribution revealed a difference in expression of E-cadherin between Swedish and Italian patients. Conclusions: In contrast to SCC of the base of the tongue and the tonsil, HPV is not present in OTSCC, excluding HPV infection as a risk factor. Higher levels of E-cadherin and young age is associated with poor survival in OTSCC patients. The different frequency of EMT markers seen between Swedish and Italian patients suggests an important role for the environment and the geographical area in the onset of different molecular patterns of OTSCC.
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Rodrigues, Priscila Campioni 1984. "Myofibroblast distribution in oral dysplasias and squamous cell carcinoma and evaluation of clinicopathological factors associated with prognosis of squamous cell carcinoma of tongue = Distribuição de miofibroblastos em lesões orais displásicas e carcinomas espinocelulares e avaliação das características clínico-patológicas associadas ao prognóstico do carcinoma espinocelular de língua." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288716.

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Orientador: Ricardo Della Coletta
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
Made available in DSpace on 2018-08-23T10:39:52Z (GMT). No. of bitstreams: 1 Rodrigues_PriscilaCampioni_M.pdf: 27970537 bytes, checksum: eb1771ac3c81d257542caac03773b5c0 (MD5) Previous issue date: 2013
Resumo: Embora várias características histopatológicas e moleculares tenham sido propostas como fatores prognósticos do carcinoma espinocelular (CEC) oral, nenhuma ainda é utilizada rotineiramente. Estudos prévios demonstraram que a presença de miofibroblastos no estroma de CECs orais é associada a um pior prognóstico e que pacientes jovens apresentam tumores com comportamento biológico distinto quando comparado ao de pacientes idosos. Os objetivos deste estudo foram 1) avaliar a influência das características demográficas, clínicas e histopatológicas no prognóstico dos CECs de língua, 2) avaliar a frequência de miofibroblastos em displasias orais (leve, moderada e severa), CECs (lesões bem diferenciadas e pobremente diferenciadas) e carcinomas verrucosos (uma variante bem diferenciada do CEC oral) e comparar a frequência destas células com hiperplasias fibrosas (HF) e 3) comparar a densidade de miofibroblastos entre CEC orais de pacientes jovens (<40 anos) e pacientes idosos (>45 anos). Para determinar a influência das características clínicas, demográficas e histopatológicas (risco histológico de Brandwein-Gensler) no prognóstico dos CECs de língua, um estudo retrospectivo com 202 pacientes foi realizado. A detecção de miofibroblastos foi realizada por reações de imuno-histoquímica para a isoforma ? da actina de músculo liso (?-SMA) em HFs com epitélio normal (n=29), displasias (n=69), CECs bem diferenciados (n=19), CECs pobremente diferenciados (n=18) e carcinomas verrucosos (n=8). A comparação entre CECs de pacientes jovens e de pacientes idosos foi realizada em um segundo grupo contendo 29 amostras pareadas para localização, estádio clínico e graduação histológica. A análise multivariada de Cox revelou que estádio T, estádio N e recorrência foram fatores independentes das sobrevidas global, específica e livre de doença para os pacientes com CEC de língua. O risco histológico não correlacionou com o prognóstico destes pacientes. HFs e displasias orais não apresentam miofibroblastos, enquanto que 62,2% dos CECs demonstraram miofibroblastos no estroma tumoral. A presença de miofibroblastos foi significantemente mais frequente nos CECs pobremente diferenciados em comparação aos CECs bem diferenciados ou aos carcinomas verrucosos. Não houve diferença estatisticamente significante entre a densidade de miofibroblastos nos CECs de pacientes jovens e idosos. Os resultados deste estudo demonstram que as características clínicas são melhores fatores preditivos para o prognóstico do CEC de língua do que o risco histológico e que a presença de miofibroblastos não é associada com displasias orais, mas tumores pobremente diferenciados apresentam uma densidade significantemente maior que tumores bem diferenciados. O estudo revelou também que a presença de miofibroblastos no estroma dos CECs de língua não diferencia entre tumores em pacientes jovens e idosos
Abstract: Although several histopathological and molecular features have been proposed as prognostic factors of the oral squamous cell carcinoma (OSCC), any is routinely used. Previous studies have demonstrated that the presence of myofibroblasts in the stroma of the OSCC is associated with a worse prognosis and that young patients have tumors with a particular biological behavior when compared with older patients. The aims of this study were 1) to evaluate the influence of the demographics, clinical and histopathological features in the prognostic of SCC of tongue, 2) to determine the frequency of myofibroblasts in the oral dysplasias (mild, moderate and severe), OSCC (well differentiated and poorly differentiated) and verrucous carcinoma (a well differentiated variant of the OSCC) and compare the density of this cell with fibrous hyperplasias and 3) to compare the density of myofibroblasts among OSCC of young patients (< 40 years) and older patients (> 45 years). To determine the influence of the clinical, demographic and histopathological (histologic risk of Brandwein-Gensler) features in the prognostic of SCCs of tongue, a retrospective study was realized with 202 patients. Myofibroblasts were detected by immunohistochemical analysis of ? smooth muscle actin (?-SMA) in fibrous hyperplasia with normal epithelium (n=29), oral dysplasias (n=69), well differentiated OSCC (n=19), poorly differentiated OSCC (n=18) and verrrucous carcinoma (n=8). The comparison between OSCC affecting young patients and older patients was realized in a second group containing 29 samples paired to localization, clinical stage and histological differentiation. Cox multivariate analysis revealed that the T stage, N stage and recurrence were independent factors of overall survival, disease-especific survival and disease-free survival. The histologic risk was not correlated with the prognostic of the patients. Fibrous hyperplasia and oral dysplasias did not show myofibroblasts in the stroma. The presence of myofibroblasts was higher in the poorly differentiated OSCCs when compared with well differentiated OSCC or with verrucous carcinomas. No significant differences existed between the presence of stromal myofibroblasts of OSCC affecting young and old individuals. The results of this study demonstrated that the clinical features were best predictive factors to the SCC of tongue prognostic than the histologic risk, and the presence of myofibroblasts was not associated with the oral dyspasias. However the poorly differentiated tumors demonstrated a higher expression of myofibroblasts than well differentiated tumors. The study also revealed that the presence of myofibroblasts in the OSCC not show differences among young and older patients
Mestrado
Patologia
Mestra em Estomatopatologia
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Sundquist, E. (Elias). "The role of tumor microenvironment on oral tongue cancer invasion and prognosis." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526217659.

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Abstract Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity. The 5-year mortality of OTSCC remains at about 50%. The tumor microenvironment (TME) is now recognized as an important factor in cancer progression and metastasis, as well as a tool for prognostication. The aim of this study was to elucidate the roles of TME hypoxia and soluble factors on cancer cell migration and invasion, and the prognostic value of two extracellular matrix (ECM) molecules: tenascin-C (TNC) and fibronectin (FN). Hypoxia was studied using oral squamous cell carcinoma cells in migration and invasion assays. Invasion assays were carried out using a 3D-myoma invasion method. Similarly, the effect of soluble factors as well as ECM alterations were studied using the myoma model: the effect of soluble factors was studied by rinsing the myoma discs prior to experiments, and ECM alterations by lyophilizing and rehydrating. ECM was further studied by analyzing the prognostic value of TNC and FN from OTSCC samples. The effect of hypoxia was shown to be OTSCC cell line dependent: the effect of hypoxia on migration and invasion was increased in aggressive cell lines. Additionally, the response to hypoxia was altered in rinsed tissue. Tissue rinsing media were analyzed and factors affecting cell motility were found. The TME was found to be pivotal for cancer invasion: invasion was impaired in non-neoplastic tissue. Furthermore, changes in the ECM by lyophilization and rehydration led to a change in the invasion mechanism. High expression of stromal TNC and FN were excellent prognosticators in early-stage OTSCC. In conclusion, the present study highlighted the role of various TME components in cancer cell invasion as well as prognostication in OTSCC. Additionally, this study provided feasible tools for more precise diagnosis of early-stage OTSCC
Tiivistelmä Liikkuvan kielen levyepiteelikarsinooma (OTSCC) on suuontelon yleisin syöpä. Viiden vuoden kuolleisuus OTSCC:an on edelleen noin 50 %. Kasvaimen mikroympäristön (TME) tiedetään nykyään olevan tärkeässä roolissa syövän kehityksessä ja etäpesäkkeiden muodostuksessa, sekä tarjoavan työkaluja ennusteiden laadintaan. Tämän tutkimuksen tarkoituksena oli selvittää TME:n hypoksian ja liukoisten tekijöiden vaikutusta syöpäsolujen liikkumiseen ja invaasioon ympäröivään kudokseen, sekä tutkia kahden solunulkoisen matriksin (ECM) proteiinin, tenaskiini-C:n (TNC) ja fibronektiinin (FN), vaikutusta OTSCC:n ennusteeseen. Hypoksian vaikutusta tutkittiin käyttäen suun levyepiteelikarsinoomasoluja liikkuvuus- ja invaasiokokeissa. Invaasiokokeissa hyödynnettiin kolmiulotteista ihmisen myoomaan perustuvaa invaasiomallia. Myös liukoisten tekijöiden ja ECM:n muutosten vaikutusten tutkimisessa käytettiin myoomamallia: liukoisten tekijöiden vaikutusta tutkittiin huuhtomalla myoomakiekot ennen niiden käyttämistä, ja ECM:n muutosten vaikutusta kylmäkuivaamalla ja uudelleen nesteyttämällä myoomakiekot. ECM:ia tutkittiin myös analysoimalla TNC:n ja FN:n värjäytyvyyden merkitystä OTSCC:n ennusteessa. Hypoksian vaikutus osoittautui solulinjariippuvaiseksi: hypoksia lisäsi kielisyöpäsolujen liikkuvuutta ja invaasiota eniten aggressiivisimmilla solulinjoilla. Lisäksi solujen vaste hypoksialle oli erilainen huuhdotussa kudoksessa. Huuhteluliuos analysoitiin ja siitä löydettiin solujen liikkumiseen vaikuttavia tekijöitä. TME:n havaittiin olevan ratkaisevassa roolissa syöpäsolujen invaasiossa: syöpäsolut eivät kyenneet invasoitumaan lainkaan ei-neoplastiseen kudokseen. Lisäksi muutosten ECM:ssä havaittiin johtavan muutoksiin solujen käyttämässä invaasion mekanismissa. Strooman TNC:n ja FN:n värjäytyvyyden todettiin olevan erinomaisia ennustekijöitä aikaisen vaiheen OTSCC:ssa. Tiivistettynä voidaan todeta, että tämä tutkimus alleviivasi useiden TME:n komponenttien vaikutusta syövän invaasiolle ja ennusteelle OTSCC:ssä. Lisäksi se tarjoaa käyttökelpoiset työkalut (TNC ja FN) tarkemmalle diagnostiikalle aikaisen vaiheen OTSCC:ssä
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Väyrynen, O. (Otto). "Factors affecting aggressive oral tongue cancer invasion and development of in vitro models for chemoradiotherapy assay." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526222813.

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Abstract Tumor associated macrophages (TAMs) are linked to the invasion of oral tongue squamous cell carcinoma (OTSCC). We modified THP-1 leukemia cells to M1 (inflammatory), M2 (TAM-like) and R848 (imidazoquinoline-treated) type macrophages in order to examine their interactions with OTSCC-cells (HSC-3) by using different kinds of in vitro migration and invasion models. We observed that interaction of TAM-resembling M2-type macrophages with HSC-3 cells induced invasion and migration, whereas the influence of M1 macrophages reduced them. Patient response to chemoradiotherapy is highly reliant on the characteristics such as the aggressiveness and stage of the cancer. Therefore, new methods for treatment testing are needed in order to design personalized therapies. We tested the applicability and consistency of human TME mimicking tissue methods for analyzing the effects of chemoradiation using commercial OTSCC cell lines. Based on our trials, both our human uterine leiomyoma tissue -based matrix models provide viable platforms for future in vitro chemoradiotherapy testing. Conventionally pro-tumorigenic activities of matrix metalloproteinase (MMP)9 have been linked with oral squamous cell carcinoma, but recently its tumor-suppressor role has also been revealed. Our study provides strong evidence that MMP9 also has an anti-invasive effect in OTSCC and is a potential mediator of the protective effects of arresten in tongue cancer cells
Tiivistelmä Makrofageilla on yhteys kielen levyepiteelikarsinooman invaasioon eli syöpäkasvaimen tunkeutumiseen ympäröivään kudokseen. Tutkimuksessamme muokkasimme ihmisen THP-1 leukemiasoluja kemiallisesti tulehdusreittejä aktivoiviksi M1-makrofageiksi, kasvaimeen liittyvien makrofagien kaltaisiksi M2-makrofageiksi sekä imidatsokinoliini-käsitellyiksi R848-makrofageiksi. Tarkoituksenamme oli tutkia makrofagien ja kielisyöpäsolujen vuorovaikutuksia erilaisilla in vitro migraatio- ja invaasiomalleilla. Anti-inflammatoristen, syövän etenemistä edesauttavien TAM-makrofagien kaltaisiksi erilaistetut M2-tyypin makrofagit lisäsivät HSC-3 kielikarsinoomasolujen invaasiota ja migraatiota, kun taas M1-tyypin makrofagien vaikutus oli päinvastainen. Potilaan vaste kemosädehoitoon riippuu syöpäkasvaimen ominaisuuksista, kuten syöpäsolujen aggressiivisuudesta ja syövän levinneisyysasteesta. Tämän vuoksi on tarve uusille menetelmille, joiden avulla voidaan ottaa huomioon potilaan sekä syöpätyypin yksilölliset ominaisuudet hoitoa suunniteltaessa. Testasimme syöpäkasvaimen mikroympäristöä mallintavien, ihmiskudokseen perustuvien menetelmien käyttökelpoisuutta ja luotettavuutta kemosädehoidon vaikutusten arvioimiseen. Testiemme perusteella myoomakudokseen pohjautuvat menetelmät voivat auttaa kemosädehoidon vaikutusten testauksessa. Matriksin metalloproteinaasi (MMP) 9:n on pitkään uskottu olevan yksinomaan syövän etenemistä edesauttava molekyyli. Viimeaikaisissa tutkimuksissa on myös havaittu, että MMP9:llä voi olla syövältä suojaavia vaikutuksia. Tutkimme MMP9:n vaikutusta kielisyöpäsoluihin ja havaitsimme, että MMP9:llä on myös invaasiota hillitseviä vaikutuksia. Lisäksi MMP9 saattaa toimia verisuonten muodostumista estävän arresten-molekyylin syövältä suojaavien mekanismien välittäjänä
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Carvalho, Larissa Kim Higashi de. "Avaliação dos efeitos pró apoptóticos da fosfoetanolamina sintética e da formulação lipossomal DODAC/FOS em células de carcinoma espinocelular da cavidade oral." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-31072017-132005/.

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Os carcinomas de cabeça e pescoço correspondem a 10% de todos dos tumores malignos, destes aproximadamente 40% se manifestam na boca e 90% correspondem ao carcinoma espinocelular. Os principais agentes carcinogênicos relacionados ao câncer bucal são o tabaco e o álcool. A cirurgia é o tratamento de eleição para o carcinoma de boca seguido dos tratamentos quimio e radioterápicos. O uso de lipossomas como vetor de quimioterápicos abre grandes perspectivas para o tratamento do câncer, pois possibilitam maior eficácia, reduzindo a toxicidade e a dosagem do fármaco. Neste projeto foram avaliados os efeitos pró apoptóticos \"in vitro\" da fosfoetanolamina sintética (FOS) e da sua formulação lipossomal DODAC/FOS em duas linhagens celulares de carcinoma espinocelular de língua humano, SCC-9 e SCC-25. A FOS, a formulação lipossomal DODAC/FOS e o carreador DODAC vazio apresentam diferentes significados em seu potencial citotóxico. A FOS aumentou significativamente a formação de lipoperóxidos pela membrana celular nas maiores concentrações estudadas. A análise das fases do ciclo celular mostrou aumento significativo da população de células com DNA fragmentado em ambas as linhagens celulares induzindo a morte celular por apoptose com aumento da expressão de Bad, Bax, citocromo c e diminuição de Bcl-2, como também alterou o potencial elétrico mitocondrial promovendo a ativação da caspase-3. A FOS e a formulação lipossomal DODAC/FOS induziram retração dos filamentos de actina e fragmentação do DNA. O conjunto de resultados mostra que o composto FOS e a sua formulação lipossomal DODAC/FOS atuam nos efeitos citotóxicos e antitumoral promovidos por estes alquilfosfoésteres, sendo capazes de induzir a morte celular por apoptose em diferentes apresentações
Head and neck carcinomas account for 10% of all malignant tumors, approximately 40% of these tumors manifest in the mouth and 90% correspond to squamous cell carcinoma. The main carcinogenic agents related to oral cancer are tobacco and alcohol. Surgery is the treatment of choice for oral carcinoma followed by chemo and radiotherapeutic treatments. The use of liposomes as a vector of chemotherapy offers great prospects for treatment of cancer, as they allow greater efficacy, reducing the toxicity and the dosage of drug. In this project, in vitro pro apoptotic effects of synthetic phosphoethanolamine (Pho-S) and DODAC/Pho-S liposomal formulation were evaluated in two human tongue squamous cell carcinoma cell lines, SCC-9 and SCC-25. Pho-S, DODAC/Pho-S liposomal formulation and the empty DODAC carrier have different meanings in their cytotoxic potential. Pho-S significantly increased the formation of lipoperoxides by cell membrane in higher concentrations studied. Analysis of the cell cycle phases showed a significant increase in the cell population with fragmented DNA in both cell lines inducing apoptosis cell death with increase expression of Bad, Bax, cytochrome c and decrease of Bcl-2, as well as altered the potential mitochondrial activation promoting caspase-3 activation. Pho-S and the DODAC/Pho-S liposomal formulation induced retraction of the actin filaments and DNA fragmentation. The set of results shows that the Pho-S compound and its liposomal formulation DODAC/Pho-S act on the cytotoxic and antitumor effects promoted by these alkylphosphoesters, being able to induce cell death by apoptosis in different presentations
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Silveira, Ericka Janine Dantas da. "Carcinoma epiderm?ide de l?ngua :correla??o cl?nica, histol?gica e imuno-histoqu?mica." Universidade Federal do Rio Grande do Norte, 2004. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17105.

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Oral squamous cell carcinoma is the most common malignant neoplasm in oral cavity. Several studies have been carried out to establish biologic behaviour criteria of this neoplasm. Thus, the purpose of this experiment was to performe a clinic, morphologic and immunohistochemical analysis, by the expression of cytokeratins 7, 10, 13, 14, 16 and 19 in 30 cases of tongue squamous cell carcinoma from the files of Dr. Luiz Ant?nio Hospital (Natal-RN). It was verifeid of the immunoexpression the correlation clinic estadiament and histologic gradation system proposed by Bryne (1998), in order to investigate the use of these intermediate filaments as an indicator of tumour progression. Data was collected from the patients file and it was observed that information regarding sex, age and race was resemble to the literature. Data obtained from disease evolution, clinic estadiament, metastasis and expression of cytokeratins 7, 10, 13, 14, 16 and 19 was submited to statistical analysis (Test K2), which showed that only the histologic gradation didn t demonstrated significant correlation to the clinic variables. The expression the cytokeratins presented variation in the analysed tumours. CK 10 expression showed significant correlation to metastasis, and the presence of CK 16 was related to disease evolution (obit/remission) and also with the T3 and T4 of TNM. These results evidenced that metastasis and TNM showed a good efficacy as a prognostic indicator. The histologic gradation proposed by Bryne (1998) didn t reflect the biologic behaviour of the studied tongue squamous cell carcinoma, and the analysis of some intermediate filaments of cytokeratins seems to reflect the biologic behaviour and agressivity of some oral squamous cell carcinoma
O carcinoma epiderm?ide oral ? a neoplasia maligna mais freq?ente na cavidade oral. Muitas pesquisas desenvolvidas visam estabelecer crit?rios que determinem o comportamento biol?gico dessa neoplasia, assim, objetivou-se com esse trabalho realizar uma an?lise cl?nica, morfol?gica e imuno-histoqu?mica atrav?s da express?o das citoqueratinas 7, 10, 13, 14, 16 e 19 em 30 casos de carcinoma epiderm?ide de l?ngua retirados dos arquivos do Hospital Dr. Luiz Ant?nio (Natal-RN), correlacionando essa express?o ao estadiamento cl?nico e grada??o histol?gica de malignidade proposto por Bryne (1998), com o intuito de verificar a utiliza??o destes filamentos intermedi?rios como indicadores de progress?o tumoral. Ap?s a an?lise cl?nica das informa??es contidas nos prontu?rios desses pacientes verificamos que os dados referentes a sexo, idade e ra?a se assemelham aos da literatura pertinente. Os dados obtidos em rela??o ao desfecho da doen?a, estadiamento cl?nico, presen?a de met?stase, grada??o histol?gica de malignidade, e express?o das citoqueratinas 7, 10, 13, 14, 16 e 19 foram submetidos a an?lise estat?stica (teste Qui2), observando-se que somente a grada??o histol?gica de malignidade n?o apresentou correla??o significativa com as vari?veis cl?nicas estudadas. A express?o dessas citoqueratinas foi variada nos tumores analisados. A express?o da CK 10 mostrou correla??o estatisticamente significativa com a presen?a de met?stase, a presen?a da CK 16 correlacionou-se ao desfecho da doen?a (?bito/remiss?o) e ainda aos est?gios III e IV do TNM. Esses resultados evidenciaram que a met?stase e o estadiamento cl?nico (TNM) mostraram boa efetividade como indicadores de progn?stico. O sistema de grada??o histol?gica de malignidade proposto por Bryne (1998) n?o refletiu o comportamento biol?gico dos carcinomas epiderm?ides de l?ngua estudados, e a an?lise de alguns filamentos intermedi?rios de citoqueratinas parece refletir o comportamento biol?gico e agressividade dos carcinomas epiderm?ides orais
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Jonsson, Eva Lindell. "Biomolecular markers in head and neck cancer." Doctoral thesis, Uppsala universitet, Öron-, näs- och halssjukdomar, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306126.

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Head and neck cancer is a heterogeneous group of tumours, of which certain subgroups such as cancer of the mobile tongue frequently are associated with a relatively poor prognosis due to the high risk of regional failure and mortality rates that haven’t improved in a significant way over the last 3 decades, despite advancements in both diagnostics and treatment. Today we lack means to assess the biological aggressiveness of each individual tumour, which varies largely. Treatment comprises of surgery with additional radiotherapy and medical therapies in more advanced tumours. The focus in this thesis is on molecular biomarker expression in head and neck cancer and especially in association with radiotherapy. Increased knowledge paves the way to a more individualized cancer treatment aiming for better outcome and less overtreatment and sequelae. The aims of this thesis was: To map the effects of radiotherapy in both tumour and adjacent tissue for the possible markers hyaluronan, EGFR and mast cells. To investigate whether the expression of hyaluronan in the epithelium and connective tissue stroma and EGFR in the tumour correlates with the risk for developing cervical metastasis in N0 patients, and to find out whether the 3-year tumour-specific survival rates correlates with the expression of HA in the epithelium and EGFR in the tumour. To establish an animal model for radiation-induced mucositis and to use that model to examine the pattern of invading inflammatory cells. To investigate whether the expression of podoplanin in tongue cancer correlates with the risk for cervical metastasis and to determine whether the total amount of lymph vessels in the diagnostic biopsy has any impact on the clinical outcome. To investigate the differences in the metabolome of tongue cancer cell lines with different radiosensitivity. The most important findings of this thesis were: The expression of EGFR and hyaluronan hade the same pattern of expression in both tumour and adjacent tissues before radiotherapy. The expression of EGFR was increased in the epithelium of the adjacent tissue close to the tumour after radiotherapy. The intensity of the staining of hyaluronan was correlated to the 3-year survival rates in patients with tongue cancer. An experimental model for radiation-induced oral mucositis in rat was established and in this model a temporal pattern of macrophage invasion with two different subtypes of macrophages was found. There were no correlation between the expression of podoplanin in the tumour tissue and the cervical metastasis rate in patients with tongue cancer, but the younger patients were more likely to have a higher expression of podoplanin in their tumour than elder patients. Tongue cancer cell lines with different radiosensitivity respond to irradiation with different patterns of metabolic expressions.
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Nascimento, George Jo?o Ferreira do. "Associa??o entre polimorfismos funcionais nos genes da MMP-7 e MMP-9 e o perfil clinicopatol?gico do carcinoma epiderm?ide de l?ngua." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17145.

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Matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) modulate important functions strictly related to the development, invasion and metastasis of several human cancers among them the squamous cell carcinoma of the tongue (SCCT). However, individual genetic factors such as the functional single nucleotide polymorphisms (SNPs) influence the pattern of protein expression of these MMPs and thus may be related to the variability observed in the clinical behavior of patients with SCCT. In this context, the present cross-sectional study aimed to evaluate the association between the frequency of the functional SNPs MMP-7 -181 A/G and MMP-9 -1562 C/T and the clinical (age, gender and metastasis) and pathological (malignancy histological grading and immunohistochemistry expression) features of SCCT cases. Genotyping of these SNPs were performed by PCR-RFLP on DNA samples from 71 cases of SCCT and 60 individuals without cancer who constitute the control group. Among the results of this research, it was observed that the frequency of the polymorphic alleles MMP-7 -181 G and MMP-9 -1562 T in SCCT patients was 28% and 12%, respectively, and the frequency of the heterozygotes A/G (PR = 2.00; p < 0.001) and C/T (PR = 1.54; p = 0.014) were significantly higher in the patient group than in the controls. The prevalence of patients carrying the combination of SNPs studied was significantly associated with SCCT cases (PR = 2.00; p = 0.011) and metastasis (PR = 2.00; p < 0.001). Furthermore, with the frequency of SNPs analyzed, the age, gender, histological grading and immunoreactivity of MMP-7 and MMP-9 formed clinical and pathological parameters relevant to the identification of population subgroups more related to the development of SCCT and metastasis. Based on these results, it is suggested that the protein expression levels of MMP-7 and -9 substantially influence the balance between their pro- and anticancer biological functions and hence the clinicopathological profile of the squamous cell carcinoma of the tongue
As metaloproteinases da matriz extracelular-7 (MMP-7) e -9 (MMP-9) modulam importantes fun??es relacionadas ao desenvolvimento, invas?o e met?stase de diversos c?nceres humanos, dentre os quais o carcinoma epiderm?ide de l?ngua (CEL). Entretanto, fatores gen?ticos individuais, tais como polimorfismos de nucleot?deo ?nico (SNPs) funcionais, influenciam no padr?o de express?o proteica dessas MMPs, podendo estar relacionados ? variabilidade no comportamento cl?nico tumoral observado em pacientes com CEL. Neste contexto, o presente trabalho objetivou, atrav?s de an?lise em sec??o transversal, estudar a associa??o entre a frequ?ncia dos SNPs funcionais MMP-7 -181 A/G e MMP-9 -1562 C/T e as caracter?sticas cl?nicas (idade, sexo e met?stase) e patol?gicas (grada??o histol?gica e express?o imuno-histoqu?mica) em uma s?rie de casos de CEL. A genotipagem dos referidos SNPs foi executada por PCR-RFLP em amostras de DNA de 71 casos de CEL e de 60 indiv?duos sem c?ncer, que constitu?ram o grupo controle. Dentre os resultados da presente pesquisa, evidenciou-se que a frequ?ncia dos alelos polim?rficos MMP-7 -181 G e MMP-9 -1562 T nos pacientes com CEL foi de 28% e 12%, respectivamente, sendo as frequ?ncias dos heterozigotos A/G (RP = 2.00; p < 0.001) e C/T (RP = 1.54; p = 0.014) significativamente maiores neste grupo de pacientes que no grupo controle. A preval?ncia dos pacientes portadores da combina??o dos SNPs estudados associou-se significativamente aos casos de CEL (RP = 2.00; p = 0.011) e ? met?stase (RP = 2.00; p < 0.001). Ademais, junto ? frequ?ncia dos SNPs analisados, a idade, sexo, grada??o histol?gica e imunoexpress?o da MMP-7 e -9 constitu?ram par?metros clinicopatol?gicos relevantes para a identifica??o de subgrupos populacionais mais predispostos ao desenvolvimento do CEL e met?stase. Frente a estes resultados, sugere-se que os n?veis de express?o da MMP-7 e -9 influenciam consideravelmente no balan?o entre suas fun??es pr? e antineopl?sicas e, consequentemente, no perfil clinicopatol?gico do carcinoma epiderm?ide de l?ngua.
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Liu, Xiaobing. "Dysregulation of microRNAs in tongue squamous cell carcinoma." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/b40203499.

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Books on the topic "Oral Tongue Squamous Cell Carcinoma"

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Thankappan, Krishnakumar. Per Oral Resection of Oral Tongue Squamous Cell Carcinoma. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6065-1.

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Oral cancer metastasis. New York: Springer, 2010.

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Worrall, Stephen Frederick. An investigation into the association between cytochrome P450 and glutathione S-transferase detoxification enzyme polymorphisms and human oral squamous cell carcinoma. Birmingham: University of Birmingham, 1998.

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Vatsa, Dr Ritesh, Dr Jay Kishore, and Dr Shubham Kumar, eds. Oral Squamous Cell Carcinoma. AkiNik Publications, 2020. http://dx.doi.org/10.22271/ed.book.956.

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Black, Riva. Oral papillary squamous cell carcinoma: Its relation to human papillomavirus infection and associated cell cycle deregulation. 2005.

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L, Nielsen Frederik, ed. Progress in oral cancer research. New York: Nova Biomedical Books, 2008.

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Nielsen, Frederik L. Progress in Oral Cancer Research. Nova Science Pub Inc, 2007.

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Myers, Jeffrey. Oral Cancer Metastasis. Springer, 2014.

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Thun, Michael J., and Neal D. Freedman. Tobacco. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0011.

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Tobacco is the leading preventable cause of cancer and other non-communicable diseases worldwide. IARC and the U.S. Surgeon General designate over twenty cancer sites or subsites as causally related to active cigarette smoking, including lung, oral cavity, nasal cavity and accessory sinuses, naso- oro- and hypopharynx, larynx, esophagus (squamous cell carcinoma and adenocarcinoma), stomach, pancreas, colorectum, liver, kidney (adeno- and transitional cell carcinoma), ureter, urinary bladder, uterine cervix, ovary (mucinous), and acute myeloid leukemia. Even this list may be incomplete, as it does not include sites for which the evidence is still considered limited, such as advanced prostate cancer and breast cancer. In addition to cigarettes, all other forms of smoked and conventional smokeless tobacco products, as well as involuntary exposure to tobacco smoke, cause cancer. The use of multiple tobacco products continues to complicate tobacco control, as does the recent introduction of novel products such as e-cigarettes.
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Book chapters on the topic "Oral Tongue Squamous Cell Carcinoma"

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Mazeron, J. J., L. Grimard, and V. Benk. "Curietherapy Versus External Irradiation Combined with Curietherapy in Stage II Squamous Cell Carcinomas of Mobile Tongue and Floor of Mouth." In Carcinoma of the Oral Cavity and Oropharynx, 101–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84971-8_12.

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Thomas, Gareth J. "Oral Squamous Cell Carcinoma." In Encyclopedia of Cancer, 2650–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_4250.

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Hunter, Keith D., and Paul M. Speight. "Squamous Cell Carcinoma, Oral." In Encyclopedia of Soil Science, 347–50. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-3-319-28085-1_664.

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Kociba, Richard J., and D. G. Keyes. "Squamous Cell Carcinoma, Tongue, Rat." In Digestive System, 255–59. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-96910-2_44.

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Kociba, Richard J. "Squamous Cell Carcinoma, Tongue, Rat." In Digestive System, 305–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60473-7_45.

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Kociba, Richard J. "Squamous Cell Carcinoma, Tongue, Rat." In Digestive System, 305–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-662-25996-2_45.

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Bai, James, and Lev Bangiyev. "Base of the Tongue Squamous Cell Carcinoma." In PET/MR Imaging, 225–26. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65106-4_96.

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Moore, Antony S., and Angela E. Frimberger. "Oral Squamous Cell Carcinoma in Cats." In Oncology for Veterinary Technicians and Nurses, 260–63. Ames, Iowa, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119264903.ch32.

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Andreadis, Dimitrios A., Achilleia-Maria Pavlou, and Prashanth Panta. "Biopsy and Oral Squamous Cell Carcinoma Histopathology." In Oral Cancer Detection, 133–51. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-61255-3_6.

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Kuriakose, Moni Abraham, and Nirav P. Trivedi. "Surgical Management of Oral Squamous Cell Carcinoma." In Contemporary Oral Oncology, 147–87. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-14917-2_6.

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Conference papers on the topic "Oral Tongue Squamous Cell Carcinoma"

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Rozenberg, B., R. Duffy, E. Hansen, and J. Robinson. "Isolated Right Ventricular Metastasis from Oral Tongue Squamous Cell Carcinoma." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6941.

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Wangsa, Darawalee, Michael Ryott, Göran Elmberger, Alejandro A. Schäffer, Gert Auer, Elisabeth Åvall Lundqvist, Eva Munck-Wikland, Thomas Ried, and Kerstin Heselmeyer-Haddad. "Abstract 333: FISH markers in oral tongue squamous cell carcinoma." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-333.

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Liu, Jiahui, Yu Wang, Kaile Wang, Jue Zhang, Jing Fang, Jinsong Guo, Jue Zhang, Jing Fang, and Jing Wang. "Radiosensitization of oral tongue squamous cell carcinoma by nanosecond pulsed electric fields." In 2016 IEEE International Conference on Plasma Science (ICOPS). IEEE, 2016. http://dx.doi.org/10.1109/plasma.2016.7534075.

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Adduri, Raju Sr, Viswakalyan Kotapalli, Neha Ak Gupta, Swarnalata Gowrishankar, Mukta Srinivasulu, Subramanyeshwar Rao, Shantveer G. Uppin, et al. "Abstract 1216: Analysis of genetic aberrations in squamous cell carcinoma of the oral tongue." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1216.

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Adduri, Raju S., Viswakalyan Kotapalli, Rajender K. K, Swarnalata Gowrishankar, Saumyadipta Pyne, Mukta Srinivasulu, Subramanyeshwar Rao, et al. "Abstract 1883: Clinical and molecular genetic analysis of squamous cell carcinoma of the oral tongue." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1883.

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Wang, Steven J., Saurabh Asthana, Annemieke van Zante, Adam B. Olshen, Frank McCormick, and Osamu Tetsu. "Abstract 3104: Establishment of an oral tongue squamous cell carcinoma cell line from a never-smoking patient." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3104.

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Vettore, Andre L., Kalpana Ramnarayanan, Choon Kiat Ong, Hui Sun Leong, Weng Khong Lim, Ioana Cutcutache, John R. Mcpherson, et al. "Abstract 3874: Mutational landscapes of oral tongue squamous cell carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3874.

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Lim, Annette M., Hongdo Do, Richard J. Young, Stephen Q. Wong, Christopher Angel, Marnie Collins, Elena Takano, et al. "Abstract 4693: Characterization of the differential mechanisms ofCDKN2Ainactivation in oral tongue squamous cell carcinomas and correlation with patient outcome." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4693.

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Skakamoto, Koji, Yorihisa Imanishi, Masayuki Shimoda, Kaori Kameyama, Toshiki Tomita, Hiroyuki Ozawa, Seiichi Shinden, et al. "Abstract 5213: Overexpression of SIP1 and down-regulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-5213.

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Yang, Caiyun, Jianqiang Li, Ji-Jiang Yang, Shi Chen, Qing Wang, Hui Pan, Siyuan Liang, and Weiliang Qiu. "Differentially Variable Genes of Oral Squamous Cell Carcinoma." In the 3rd International Conference. New York, New York, USA: ACM Press, 2018. http://dx.doi.org/10.1145/3265689.3265711.

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Reports on the topic "Oral Tongue Squamous Cell Carcinoma"

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Wang, Dong, XiaoJie Duan, Yuhui Zhang, Zhen Meng, and Jing Wang. Traditional Chinese medicine for oral squamous cell carcinoma: A Bayesian network meta-analysis protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2020. http://dx.doi.org/10.37766/inplasy2020.9.0082.

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Wang, Mingfei, Linfeng Zhang, Wenhao Ren, Shaoming Li, Keqian Zhi, Jingjing Zheng, and Ling Gao. Diagnostic Value of CircRNAs as Potential Biomarker in Oral Squamous Cell Carcinoma: A Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0037.

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Liang, Feixin. Effect of reactive oxygen species on the ligand-independent activation of EGFR in tongue squamous cell carcinoma. Science Repository, June 2018. http://dx.doi.org/10.31487/j.dobcr.2018.02.005.

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Kloss-Brandstatter, A., G. Erhart, H. Weissensteiner, G. Schafer, L. Forer, S. Schonherr, D. Pacher, et al. Somatic mitochondrial DNA mutations are associated with progression, metastasis and death in oral squamous cell carcinoma. Cold Spring Harbor Laboratory, January 2014. http://dx.doi.org/10.1101/002055.

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You might also be interested in the extended bibliographies on the topic 'Oral Tongue Squamous Cell Carcinoma' for particular source types:
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