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Journal articles on the topic 'Oral Tongue Squamous Cell Carcinoma'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Maxwell, Jessica H., Lester D. R. Thompson, Margaret S. Brandwein-Gensler, Bernhard G. Weiss, Martin Canis, Bibianna Purgina, Arpan V. Prabhu, et al. "Early Oral Tongue Squamous Cell Carcinoma." JAMA Otolaryngology–Head & Neck Surgery 141, no. 12 (December 1, 2015): 1104. http://dx.doi.org/10.1001/jamaoto.2015.1351.

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2

Su, Yan-Ye, Chang-Han Chen, Chih-Yen Chien, Wei-Che Lin, Wan-Ting Huang, and Shau-Hsuan Li. "Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma." Journal of the Renin-Angiotensin-Aldosterone System 18, no. 3 (July 2017): 147032031771790. http://dx.doi.org/10.1177/1470320317717904.

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Introduction: Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. However, the role of the mitochondrial assembly receptor in the prognosis of cancer patients remains unclear. The aim of this study was to evaluate the significance of mitochondrial assembly receptor signaling in the prognosis of oral tongue squamous cell carcinoma. Methods: Mitochondrial assembly receptor immunohistochemistry was examined in 151 oral tongue squamous cell carcinoma patients and was correlated with treatment outcome. The functional relevance of the mitochondrial assembly receptor in oral tongue squamous cell carcinoma cell lines was evaluated by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide reduction and bromodeoxyuridine incorporation assays. Results: Mitochondrial assembly receptor overexpression was significantly correlated with early pathological T classification ( p=0.029) and the absence of extracapsular spread ( p=0.039). Univariate analyses demonstrated that mitochondrial assembly receptor overexpression was significantly associated with superior overall survival ( p=0.012). In multivariate comparison, mitochondrial assembly receptor overexpression remained independently associated with superior overall survival ( p=0.008, hazard ratio=1.862). In vitro, angiotensin-(1-7) suppressed the cell growth in oral tongue squamous cell carcinoma cells, and this response was reversed by the mitochondrial assembly receptor antagonist, A779. Conclusion: Mitochondrial assembly receptor expression is independently associated with the prognosis of oral tongue squamous cell carcinoma patients. These findings suggest that mitochondrial assembly receptor signaling may be a promising novel target for oral tongue squamous cell carcinoma.

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3

Hainarosie, Razvan, Viorel Zainea, Mura Hainarosie, Catalina Pietrosanu, Irina Ionita, Silviu Pituru, and Dragos Cristian Stefanescu. "Methylene Blue Test in Assessing Disease Free Margins in Lingual Carcinoma Resection." Revista de Chimie 68, no. 12 (January 15, 2018): 2879–80. http://dx.doi.org/10.37358/rc.17.12.5998.

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Lingual squamous cell carcinoma is one of the most frequent localization of the oral carcinomas. The tongue neoplasia represents nearly 40% of the oral carcinomas. Recent studies showed an increasing trend of lingual carcinoma in young patients. Several staining tests have been described to early detect the disease. After detection, disease free margins resection will increase the survival rate. This study aims to analyze the methylene blue staining test in achieving disease free resection margins in lingual squamous cell carcinoma.

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4

P Ingle, Paramita, Basavaraj T Bhagawati, Pritam S Pohankar, and Meenal S Jethlia. "Oral Squamous Cell Carcinoma of Tongue - Case Report." Acta Scientific Dental Scienecs 4, no. 8 (July 23, 2020): 117–27. http://dx.doi.org/10.31080/asds.2020.04.0894.

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5

Durr, Megan L., Annemieke van Zante, David Li, Eric J. Kezirian, and Steven J. Wang. "Oral Tongue Squamous Cell Carcinoma in Never-Smokers." Otolaryngology–Head and Neck Surgery 149, no. 1 (March 26, 2013): 89–96. http://dx.doi.org/10.1177/0194599813482876.

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6

Nurrahman, Tri, Seto Adiantoro, Kiki Akhmad Rizki, and Farah Asnely. "MULTIDISCIPLINARY APPROACH IN THE TREATMENT OF SQUAMOUS CELL CARCINOMA AT REGIO GLOSSUS." Dentino : Jurnal Kedokteran Gigi 5, no. 2 (August 15, 2020): 205. http://dx.doi.org/10.20527/dentino.v5i2.8976.

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ABSTRACTBackground: Squamous Cell Carcinoma (SCC) is the most common case of oral cancer which often occurs laterally on the tongue and rarely develops on the dorsal surface of the tongue. More than half of the cases are diagnosed late, thereby reducing the survival rate of the patients. Objective: This report was intended as an evaluation for the management of squamous cell carcinoma under multidisciplinary approach between oral surgery and other departments, as well as the provision of further post-operative treatment. Case Report: The author presents a case of 68-years-old female patient with a lump and an ulcer on her tongue. Around six months prior to the visit, patient complained of tongue ulcer followed by the emergence of a lump in a size of a corn seed. The lump was gradually enlarged with constant widening of the ulcer. Pain on the tongue was also perceived. The patient was then referred to Hasan Sadikin Hospital for further treatment. Case Management: Patients underwent hemiglossectomy and Selective Neck Dissection (SND) surgical procedures performed by Oral and Maxillofacial Surgeon in collaboration with Surgical Oncologist. Furthermore, after surgery, the patient was consulted to the Hemato-Oncology Division of Internal Medicine Department for chemotherapy treatment. Conclusions: The exact diagnosis was made based on the histopathological biopsy results of the tongue tissue. Management of tongue cancer must be done multidisciplinary. Some things that must be considered in handling such cases are the eradication of the tumor, the return of oral cavity function, and the aesthetic/functional aspects of the patient. Keywords: Oral cancer, Squamous cell carcinoma, Tongue cancer

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7

Caponio, Troiano, Mascitti, Santarelli, Mauceri, and Lo Muzio. "Predicting Death in Patients with Squamous Cell Carcinoma of the Tongue." Proceedings 35, no. 1 (December 10, 2019): 18. http://dx.doi.org/10.3390/proceedings2019035018.

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Tongue squamous cell carcinoma (TSCC) accounts for 40% of all squamous cell carcinoma involving the mucosal surface of the oral cavity. TSCC is highly invasive and aggressive and, nowadays, TNM staging system is considered the gold standard in predicting patients’ outcomes. [...]

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8

KUROKAWA, Hideo, Yoshihiro YAMASHITA, Keiko MIURA, Shingo TOKUDOME, and Minoru KAJIYAMA. "Clinicopathological evaluation of oral squamous cell carcinomas. Highly invasive tongue carcinoma." Japanese Journal of Oral & Maxillofacial Surgery 45, no. 5 (1999): 324–28. http://dx.doi.org/10.5794/jjoms.45.324.

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9

Ryott, Michael, Linda Marklund, Darawalee Wangsa, Göran Elmberger, and Eva Munck-Wikland. "Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma." Journal of Oral Pathology & Medicine 40, no. 5 (April 12, 2011): 385–89. http://dx.doi.org/10.1111/j.1600-0714.2010.00992.x.

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10

Sano, Daisuke, and Jeffrey N. Myers. "Metastasis of squamous cell carcinoma of the oral tongue." Cancer and Metastasis Reviews 26, no. 3-4 (September 3, 2007): 645–62. http://dx.doi.org/10.1007/s10555-007-9082-y.

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11

Israyani, Israyani, Ayu F. Argadianti, Hening Tuti Hendarti, and Adiastuti E. P. "Managementof squamos cell carcinoma of tongue in young men: case report." Journal of Case Reports in Dental Medicine 1, no. 1 (May 1, 2019): 21. http://dx.doi.org/10.20956/jcrdm.v1i1.95.

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Background: Oral Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old. Purpose: This case report aim is to focuses on establishment of diagnosis, differential diagnosis, predisposition, and treatment planning related to the case. Case: This report describes a case of oral squamous cell carcinoma, staged T1N1M0 (stage III), involving the lateral border and ventral surface of the tongue of a 32-year old male patient, with no smoking or drinking habits. Initial tumor presentation was of deep ulceration and intense pain. Case Management: Patient has examination with autofluorence LED light, presence of bacterial growth, and FNA for establised diagnosis. Patient was given chlorine dioxide mouthwash and education for further treatment one of them is tomoterapi. Conclusions: Clinical features of deep ulceration, pain and induration may be a suspicious feature of oral cavity cancer, therefore early diagnosis of oral squamous cell carcinoma determines prognosis.Keywords: malignant, autofluoresence, tomoterap

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12

Huang, Zhiquan, Hongzhang Huang, Haigang Li, Weiliang Chen, and Chaobin Pan. "EMMPRIN expression in tongue squamous cell carcinoma." Journal of Oral Pathology & Medicine 38, no. 6 (July 2009): 518–23. http://dx.doi.org/10.1111/j.1600-0714.2009.00775.x.

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13

Sahi, Rajina, Dilip Karmacharya, and Thungathurthi Sheshagiri Rao. "Oral Squamous Cell Carcinoma in Relation with Depth of Invasion and Lymph Node Metastasis." Journal of College of Medical Sciences-Nepal 16, no. 2 (June 30, 2020): 71–73. http://dx.doi.org/10.3126/jcmsn.v16i2.28519.

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Background: Squamous cell carcinoma of oral cavity has become one of the most common malignancies in Nepal. Neck node involvement is frequently seen in this type of malignancy. Depth of invasion is one of the most important criteria for determining further management of the patient. This study is undertaken to see whether the depth of tumor invasion is a reliable parameter for predicting regional lymph node metastasis. Methods: This retrospective study was done among 85 patients of pathology department of the College of Medical Sciences Teaching Hospital, Bharatpur from May to Oct 2019. Results: This study found that most of the cases of oral squamous cell carcinoma had occurred in old age within 60-70 years of age. The most common site of occurrence for oral squamous cell carcinoma was tongue (60%), followed by lower alveolus (20%). The depth of invasion of 5mm and more was among 89% of the cases while cervical lymph node metastasis was among 53% cases. Most of the cases (60%) were well-differentiated (Grade I). There was no statistical relationship between depth of invasion and lymph node metastasis (p>0.05). Conclusions: The most common site of oral squamous cell carcinoma was tongue. Depth of invasion was not a predictor for lymph node metastasis. Keywords: depth of invasion; lymph node metastasis; oral squamous cell carcinoma; simple compass divider.

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14

Dogan, E., H. O. Cetinayak, S. Sarioglu, T. K. Erdag, and A. O. Ikiz. "Patterns of cervical lymph node metastases in oral tongue squamous cell carcinoma: implications for elective and therapeutic neck dissection." Journal of Laryngology & Otology 128, no. 3 (February 19, 2014): 268–73. http://dx.doi.org/10.1017/s0022215114000267.

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AbstractObjectives:To determine the patterns of lymph node metastases in oral tongue carcinomas, and examine the implications for elective and therapeutic neck dissection.Method:The study entailed a retrospective analysis of 67 patients with previously untreated oral tongue squamous cell carcinoma who had undergone simultaneous glossectomy and neck dissection.Results:Of the 40 clinically node-negative patients, 7 patients had metastatic lymph nodes on pathological examination. No occult metastasis was found at level IV. Of the 27 clinically node-positive patients, the incidence rate of level IV metastasis was 11.1 per cent (3 out of 27 patients). No ‘skip metastases’ were found at level IV. Level IV metastases were significantly related to clinically staged nodes categorised as over 2a (p = 0.03) and metastasis to level III (p = 0.01).Conclusion:Routine inclusion of level IV in elective neck dissection is not necessary for clinically node-negative patients with oral tongue squamous cell carcinoma. Furthermore, extended supraomohyoid neck dissection with adjuvant radiotherapy can be sufficient in the treatment of selected patients with clinically node-positive necks.

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15

Abulaban, Abdulrhman A., Lujain A. Khoja, Sara S. Baghlaf, Moataz M. Aldahlawi, and Mahmoud S. Al-Ahwal. "Tongue Squamous Cell Carcinoma in a Young Patient Free of Risk Factors:." Saudi Journal of Internal Medicine 4, no. 1 (June 30, 2014): 43–47. http://dx.doi.org/10.32790/sjim.2014.4.1.8.

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Tongue squamous cell carcinoma progresses from an oral premalignant lesion to invasive squamous cell carcinoma. The incidence of tongue carcinoma has been increasing markedly even in patients free of risk factors as the reporting case of a 22-years-old female complaining of small tender whitish discoloration over the left side of the tongue. First, there was a dilemma in the diagnosis taking in consideration that she is young and free of risk factor, but the magnetic resonance imaging of the head and neck showed a heterogenous mass in the tongue with deep muscular invasion. After the result of positron emission tomography-computed tomography, the patient underwent left hemiglossectomy with left supraomohyoid neck dissection and histopathology report showed invasive squamous cell carcinoma. Thus, she was referred for adjuvant radiotherapy. At this point, it emphasized that early recognition is essential; as an extensive history should be obtained from the patient that includes the symptoms emerged and risk factors.

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16

Abulaban, Abdulrhman A., Lujain A. Khoja, Sara S. Baghlaf, Moataz M. Aldahlawi, and Mahmoud S. Al-Ahwal. "Tongue Squamous Cell Carcinoma in a Young Patient Free of Risk Factors:." Saudi Journal of Internal Medicine 4, no. 1 (June 30, 2014): 43–47. http://dx.doi.org/10.32790/sjim.4.1.8.

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Tongue squamous cell carcinoma progresses from an oral premalignant lesion to invasive squamous cell carcinoma. The incidence of tongue carcinoma has been increasing markedly even in patients free of risk factors as the reporting case of a 22-years-old female complaining of small tender whitish discoloration over the left side of the tongue. First, there was a dilemma in the diagnosis taking in consideration that she is young and free of risk factor, but the magnetic resonance imaging of the head and neck showed a heterogenous mass in the tongue with deep muscular invasion. After the result of positron emission tomography-computed tomography, the patient underwent left hemiglossectomy with left supraomohyoid neck dissection and histopathology report showed invasive squamous cell carcinoma. Thus, she was referred for adjuvant radiotherapy. At this point, it emphasized that early recognition is essential; as an extensive history should be obtained from the patient that includes the symptoms emerged and risk factors.

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17

Baillie, Ranui, Tinte Itinteang, Helen H. Yu, Helen D. Brasch, Paul F. Davis, and Swee T. Tan. "Cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma." Journal of Clinical Pathology 69, no. 8 (April 19, 2016): 742–44. http://dx.doi.org/10.1136/jclinpath-2015-203599.

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18

Gaddikeri, Kavitha, and Deepak D. Bhorgonde. "Oral squamous cell carcinoma of tongue in a young patient- a rare case report and review of literature." Asian Pacific Journal of Health Sciences 3, no. 4 (November 30, 2016): 288–91. http://dx.doi.org/10.21276/apjhs.2016.3.4.46.

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19

Nakamori, K., H. Sunakawa, H. Hiratsuka, A. Arasaki, M. Kishaba, W. Tsuhako, K. Arakakaki, and J. Kiyuna. "Clinical study on squamous cell carcinoma of the tongue." International Journal of Oral and Maxillofacial Surgery 28 (January 1999): 127. http://dx.doi.org/10.1016/s0901-5027(99)81005-4.

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20

Suresh, Amritha, Muhil Vannan, Dhanya Kumaran, Zeynep H. Gümüs, Priya Sivadas, Elango Erode Murugaian, Vikram Kekatpure, Subramanian Iyer, Kumarasamy Thangaraj, and Moni Abraham Kuriakose. "Resistance/Response Molecular Signature for Oral Tongue Squamous Cell Carcinoma." Disease Markers 32, no. 1 (2012): 51–64. http://dx.doi.org/10.1155/2012/926703.

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Worldwide, the incidence of oral tongue cancer is on the rise, adding to the existing burden due to prevailing low survival and high recurrence rates. This study uses high-throughput expression profiling to identify candidate markers of resistance/response in patients with oral tongue cancer. Analysis of primary and post-treatment samples (12 tumor and 8 normal) by the Affymetrix platform (HG U133 plus 2) identified 119 genes as differentially regulated in recurrent tumors. The study groups had distinct profiles, with induction of immune response and apoptotic pathways in the non-recurrent and metastatic/invasiveness pathways in the recurrent group. Validation was carried out in tissues by Quantitative Real-Time PCR (QPCR) (n=30) and immunohistochemistry (IHC) (n=35) and in saliva by QPCR (n=37). The markers,COL5A1,HBB,IGLAandCTSCindividually andCOL5A1andHBBin combination had the best predictive power for treatment response in the patients. A subset of markers identified (COL5A1,ABCG1,MMP1, IL8, FN1) could be detected in the saliva of patients with oral cancers with their combined sensitivity and specificity being 0.65 and 0.87 respectively. The study thus emphasizes the extreme prognostic value of exploring markers of treatment resistance that are expressed in both tissue and saliva.

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21

Fauzi, Abul, Andri Hardianto, and Rahmat Wariz. "Hemiglosectomy with selective neck dissection in squamous cell carcinoma at tongue." Journal of Dentomaxillofacial Science 1, no. 2 (August 31, 2016): 139. http://dx.doi.org/10.15562/jdmfs.v1i2.13.

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Squamous Cell Carcinoma (SCC) is common is a malignant neoplasma originated from epithelial cells. It is usually involving the oral mucosa and underlying tissue of the tongue, hypopharynx, and also larynx. This report discussed about the management of SCC at tongue with hemiglosectomy and selective neck dissection managed in a male, 57 years old who referred with chief complaints of a mass on the tongue measuring 0.5cm that did not heal, Incision biopsy result confirms a squamous cell carcinoma with well differentiated on his tongue with enlarged lymph nodes level I ipsilateral. The patient was hospitalized and hemiglosectomy surgery with selective neck dissection was conducted, with the entire edge of the excision boundary has been free of tumor mass. Hemiglosectomy with selective neck dissection is selected depending on the size of the lesion, location of lesion and metastases occurrence.

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22

Yaacob, H. B., W. C. Ngeow, P. L. Tan, and A. R. Zainal Arif. "Lichenoid Lesion And Oral Squamous Cell Carcinoma Of The Tongue." Annals of Dentistry 9, no. 1 (December 31, 2002): 23–26. http://dx.doi.org/10.22452/adum.vol19no1.5.

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23

Yaacob, H. B., W. C. Ngeow, P. L. Tan, and A. R. Zainal Arif. "Lichenoid Lesion And Oral Squamous Cell Carcinoma Of The Tongue." Annals of Dentistry 9, no. 1 (December 31, 2002): 23–26. http://dx.doi.org/10.22452/adum.vol9no1.5.

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24

Fernandes, Rui, and R. Ord. "T1 oral tongue squamous cell carcinoma: Local and regional failures." Journal of Oral and Maxillofacial Surgery 62 (August 2004): 30–31. http://dx.doi.org/10.1016/j.joms.2004.05.157.

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25

Popovtzer, Aron, Thomas Shpitzer, Gideon Bahar, Gideon Marshak, David Ulanovski, and Raphael Feinmesser. "Squamous Cell Carcinoma of the Oral Tongue in Young Patients." Laryngoscope 114, no. 5 (May 2004): 915–17. http://dx.doi.org/10.1097/00005537-200405000-00025.

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26

RODRIGUES, PRISCILA CAMPIONI, ELIZABETE BAGORDAKIS, MARCIA MIGUEL, MARCIO AJUDARTE LOPES, TUULA SALO, LUIS PAULO KOWALSKI, and RICARDO D. COLETTA. "Clinicopathological Features in Prognosis of Oral Tongue Squamous Cell Carcinoma." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117, no. 2 (February 2014): e201. http://dx.doi.org/10.1016/j.oooo.2013.12.270.

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27

BRANDNER, CRAIG J., ERIC T. GEIST, and RONALD F. CARR. "Squamous Cell Carcinoma of the Tongue Masked by Oral Trauma." Southern Medical Journal 79, no. 11 (November 1986): 1457–58. http://dx.doi.org/10.1097/00007611-198611000-00036.

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28

Mroueh, Rayan, Aaro Haapaniemi, Reidar Grénman, Jussi Laranne, Matti Pukkila, Alhadi Almangush, Tuula Salo, and Antti Mäkitie. "Improved outcomes with oral tongue squamous cell carcinoma in Finland." Head & Neck 39, no. 7 (May 8, 2017): 1306–12. http://dx.doi.org/10.1002/hed.24744.

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29

Oliver, Jamie R., S. Peter Wu, Clifford M. Chang, Dylan F. Roden, Binhuan Wang, Kenneth S. Hu, David Schreiber, and Babak Givi. "Survival of oral tongue squamous cell carcinoma in young adults." Head & Neck 41, no. 9 (April 15, 2019): 2960–68. http://dx.doi.org/10.1002/hed.25772.

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30

Yazici, Yasemin D., Seungwon Kim, Samar A. Jasser, Zhuoying Wang, Kenny B. Carter, Corazan D. Bucana, and Jeffrey N. Myers. "Antivascular Therapy of Oral Tongue Squamous Cell Carcinoma with PTK787." Laryngoscope 115, no. 12 (December 2005): 2249–55. http://dx.doi.org/10.1097/01.mlg.0000183861.53765.77.

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31

Cassidy, R. J., J. M. Switchenko, J. T. Wadsworth, M. El-Deiry, N. F. Saba, K. A. Higgins, and J. J. Beitler. "Squamous Cell Carcinoma of the Oral Tongue: Exploring New Trends." International Journal of Radiation Oncology*Biology*Physics 90, no. 1 (September 2014): S508—S509. http://dx.doi.org/10.1016/j.ijrobp.2014.05.1561.

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32

Fan, Kang-Hsing, Chen-Yu Lin, Chung-Jan Kang, Shiang-Fu Huang, Hung-Ming Wang, Eric Yen-Chao Chen, I. How Chen, Chun-Ta Liao, Ann-Joy Cheng, and Joseph Tung-Chieh Chang. "Combined-modality treatment for advanced oral tongue squamous cell carcinoma." International Journal of Radiation Oncology*Biology*Physics 67, no. 2 (February 2007): 453–61. http://dx.doi.org/10.1016/j.ijrobp.2006.06.026.

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Arora, Karandeep Singh, Sunny Garg, Prabhpreet Kaur, and Shreeyam Mohapatra. "Primary oral tuberculosis on the tongue mimicking squamous cell carcinoma." Indian Journal of Tuberculosis 65, no. 1 (January 2018): 84–86. http://dx.doi.org/10.1016/j.ijtb.2016.09.019.

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Thiagarajan, Shivakumar, Sudhir Nair, Deepa Nair, Pankaj Chaturvedi, Shubhadra V. Kane, Jai Prakash Agarwal, and Anil K. D'Cruz. "Predictors of prognosis for squamous cell carcinoma of oral tongue." Journal of Surgical Oncology 109, no. 7 (March 12, 2014): 639–44. http://dx.doi.org/10.1002/jso.23583.

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Mlynarek, A. M., R. Balys, S. Jie, Y. Xu, M. P. Hier, M. J. Black, and M. A. Alaoui-Jamali. "A concerted cell and serum proteomic approach for the identification of oral squamous cell carcinoma biomarkers." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 5512. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5512.

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5512 Background: Head and neck squamous cell carcinoma is the sixth most common cause of cancer deaths in the world. Despite extensive research, the 5-year survival rates have not changed significantly over the last decade. Presently, the lack of serum biomarkers for head and neck carcinoma limits early diagnosis and treatment monitoring of advanced disease. In this study, we used a proteomic approach on serum from mice bearing human oral squamous cell carcinoma xenografts and from conditioned cell culture medium from matched cell lines. Methods: Oral squamous cell carcinomas, with distinct invasive phenotypes, and adjacent normal tissue were obtained from human patients, and were transplanted orthotopicaly into tongues of RAG-2/γ(c) mice. After a 20% weight loss, the mice were sacrificed by exsanguinations. Two distinct proteomic protocols were used to analyze the mouse serum. The first involved albumin depletion followed by two-dimensional gel electrophoresis and MALDI. The second arm utilized the same albumin depletion followed by multidimensional-protein-information-technology (ESI-LC and MS/MS). The top candidate proteins, which were differentially expressed in the cancer bearing mice compared to matched controls were then validated by Western blot, immunoprecipitation, immunofluorescence, and/or immunohistochemistry analyses using mouse serum and conditioned medium from matched cell lines. Results: Orthotopic implantation of human tumor tissues in mouse tongue was successful in 100% of the mice tested. The human origin of these tumors was confirmed pathologically. A correlation between disease stages and invasiveness was observed. We identified over one hundred proteins as being differentially expressed between control and cancer-bearing mice (p < 0.05), including proteins involved in cell cytoskeleton signaling. The expression of these proteins was then validated in mouse serum, tissue xenografts, and conditioned medium from oral cancer matched established cell lines. Conclusion: We report the first proteomic in-vivo model of oral cancer for the identification of low molecular weight serum biomarkers. We identified candidates that can be exploited as potential markers for diagnosis of human oral squamous cell carcinoma. No significant financial relationships to disclose.

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Qu, Xinyu, Thomas C. N. Leung, Sai-Ming Ngai, Sau-Na Tsai, Abhimanyu Thakur, Wing-Kar Li, Youngjin Lee, et al. "Proteomic Analysis of Circulating Extracellular Vesicles Identifies Potential Biomarkers for Lymph Node Metastasis in Oral Tongue Squamous Cell Carcinoma." Cells 10, no. 9 (August 24, 2021): 2179. http://dx.doi.org/10.3390/cells10092179.

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Lymph node metastasis is the most reliable indicator of a poor prognosis for patients with oral tongue cancers. Currently, there are no biomarkers to predict whether a cancer will spread in the future if it has not already spread at the time of diagnosis. The aim of this study was to quantitatively profile the proteomes of extracellular vesicles (EVs) isolated from blood samples taken from patients with oral tongue squamous cell carcinoma with and without lymph node involvement and non-cancer controls. EVs were enriched using size exclusion chromatography (SEC) from pooled plasma samples of patients with non-nodal and nodal oral tongue squamous cell carcinoma (OTSCC) and non-cancer controls. Protein cargo was quantitatively profiled using isobaric labelling (iTRAQ) and two-dimensional high-performance liquid chromatography followed by tandem mass spectrometry. We identified 208 EV associated proteins and, after filtering, generated a short list of 136 proteins. Over 85% of the EV-associated proteins were associated with the GO cellular compartment term “extracellular exosome”. Comparisons between non-cancer controls and oral tongue squamous cell carcinoma with and without lymph node involvement revealed 43 unique candidate EV-associated proteins with deregulated expression patterns. The shortlisted EV associated proteins described here may be useful discriminatory biomarkers for differentiating OTSCC with and without nodal disease or non-cancer controls.

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37

Fauzi, Abul, Andri Hardianto, and Rahmat Wariz. "Hemiglosectomy with selective neck dissection in squamous cell carcinoma at tongue." Journal of Dentomaxillofacial Science 1, no. 2 (August 31, 2016): 287. http://dx.doi.org/10.22208/jdmfs.1.2.2016.287-293.

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<p>Squamous Cell Carcinoma (SCC) is common is a malignant neoplasma originated from epithelial cells. It is usually involving the oral mucosa and underlying tissue of the tongue, hypopharynx, and also larynx. This report discussed about the management of SCC at tongue with hemiglosectomy and selective neck dissection managed in a male, 57 years old who referred with chief complaints of a mass on the tongue measuring 0.5cm that did not heal, Incision biopsy result confirms a squamous cell carcinoma with well differentiated on his tongue with enlarged lymph nodes level I ipsilateral. The patient was hospitalized and hemiglosectomy surgery with selective neck dissection was conducted, with the entire edge of the excision boundary has been free of tumor mass. Hemiglosectomy with selective neck dissection is selected depending on the size of the lesion, location of lesion and metastases occurrence.</p>

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38

Haen, Pierre, Lydie Crescence, Diane Mege, Alexandre Altié, Christophe Dubois, and Laurence Panicot-Dubois. "Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets." Biomedicines 9, no. 3 (February 24, 2021): 228. http://dx.doi.org/10.3390/biomedicines9030228.

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Venous thrombo-embolism (VTE) disease is the second most common cause of mortality in cancer patients, and evaluation and prevention of thrombosis risk is essential. VTE-associated risk varies according to the type of tumor disease. Oral cancer is the most frequent type of head and neck cancer, and it represents approximately 2.1% of all cancers worldwide. Most tumors are squamous cell carcinomas and are mainly due to tobacco and alcohol abuse. VTE risk associated with oral squamous cell carcinoma (OSCC) is low. However, many studies have shown that OSCC has the following biological features of cancers associated with a high thrombosis risk: modified thrombosis and fibrinolysis mechanisms; strong expression of procoagulant proteins; secretion of procoagulant microparticles; and production of procoagulant cytokines. Using an original mouse model of tongue squamous cell carcinoma, our study aimed to clarify this paradoxical situation. First, we showed that OSCC tumors have a pro-aggregatory phenotype and a high local thrombosis risk. Second, we found that tongue tumor mice do not have an elevated systemic thrombosis risk (the risk of an “at distance” thrombosis event such as lower extremity deep venous thrombosis or pulmonary embolism) and even show a reduction in risk. Third, we demonstrated that tongue tumor mice show a reduction in platelet reactivity, which explains the low systemic thrombosis risk. Finally, we found that tongue tumor mice present granule pool deficiency, thereby explaining the reduction in platelet reactivity and systemic thrombosis risk.

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Liu, Pei-Feng, Chun-Feng Chen, Chih-Wen Shu, Hui-Min Chang, Cheng-Hsin Lee, Huei-Han Liou, Luo-Ping Ger, Chun-Lin Chen, and Bor-Hwang Kang. "UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma." Diagnostics 10, no. 9 (September 4, 2020): 674. http://dx.doi.org/10.3390/diagnostics10090674.

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Ubiquitin-conjugating enzyme 2C (UBE2C) involves in numerous cellular processes and the tumor progression in many cancers. However, its role in oral squamous cell carcinoma (OSCC) is unclear. We aimed to investigate the role and clinical significance of UBE2C in OSCC. The expression levels of UBE2C were examined by immunohistochemistry in 185 buccal mucosa squamous cell carcinomas, 247 tongue squamous cell carcinomas (TSCCs) and 75 lip squamous cell carcinomas. The roles of UBE2C in cell growth, invasion/migration and cancer stemness were also examined in OSCC cells. The expression levels of UBE2C protein were higher in tumor tissues than they were in the corresponding tumor adjacent normal tissues from OSCC patients. Higher UBE2C expression was associated with poor cell differentiation and lymph node invasion in OSCC patients. High UBE2C expression was also correlated with shorter disease-specific survival in TSCC patients having poor cell differentiation, advanced pathological stages, lymph node metastasis as well as receiving radiation therapy. Compared to control cells, OSCC cells in which UBE2C was silenced showed decreased cell proliferation, migration/invasion and colony formation and they exhibited lower expression levels of the following cancer stemness markers—ALDH1/A2, CD44, CD166 and EpCAM. High co-expression levels of UBE2C/CD44, UBE2C/CD166 and UBE2C/EpCAM were associated with poor prognosis in oral cancer patients from The Cancer Genome Atlas database. Our findings indicated that UBE2C might be a potential biomarker for tumorigenesis and prognosis in TSCC.

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Lyanova, A. A., L. Yu Vladimirova, E. P. Ulianova, A. E. Storozhakova, N. A. Abramova, I. L. Popova, M. A. Teplyakova, et al. "Study of EGFR expression in tumor tissue in patients with locally advanced oral cavity cancer receiving cetuximab therapy." Meditsinskiy sovet = Medical Council, no. 9 (July 30, 2020): 182–89. http://dx.doi.org/10.21518/2079-701x-2020-9-182-189.

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Introduction: Squamous cell carcinoma of the oral cavity is one of the most common head and neck cancers with an aggressive course and high mortality rates. The aim of the study was to determine the EGFR expression levels in tumor tissues in patients with squamous cell carcinoma of the tongue and oral mucosa depending on the efficacy of the therapy. Material and methods: The study included 60 patients with squamous cell carcinoma of the tongue and oral mucosa T3-4N0-1M0. The main group included 30 patients receiving chemotherapy (cisplatin/fluorouracil) in combination with targeted therapy with cetuximab. The control group included 30 patients receiving chemotherapy without cetuximab. Both groups were divided into two subgroups: sensitive and resistant. Results: In treatment-resistant patients of the main group with cetuximab, the average EGFR expression was twice lower than the initial levels (p = 0.0080) and 1.7 times higher than in treatment-resistant patients of the control group (p = 0.0157). In treatment-sensitive patients, the average EGFR expression was 19.8 times lower (p = 0.0020) than initial values and 14.9 times higher (p = 0.0067) than in treatment-sensitive controls. Conclusions: A natural decrease in the EGFR expression in tumor tissues due to the targeted therapy was revealed. However, some patients were resistant to cetuximab, which dictates the need to search for predictors of targeted therapy efficacy in patients with locally advanced squamous cell carcinoma of the tongue and oral mucosa.

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Reyes, Montserrat, Gina Pennacchiotti, Fabio Valdes, Rodrigo Montes, Marcelo Veloso, Maria Angélica Matamala, Luis Zanolli, and Gonzalo Rojas-Alcayaga. "Sarcomatoid (Spindle Cell) Carcinoma of Tongue: A Report of Two Cases." Case Reports in Dentistry 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/780856.

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Sarcomatoid Carcinoma (SC) is an unusual and aggressive variant of squamous cell carcinoma, which frequently recurs and metastasizes; for this reason, the right diagnosis is very important. It is considered to be a biphasic tumor made up of cells from squamous and spindle cells carcinoma with a sarcomatous aspect, but of epithelial origin. The diagnosis often represents a clinical-pathological challenge where the study with immunohistochemical technique (IHC) is key to the histopathological diagnosis. The reported cases related to oral mucosa are limited. In this work we present two SC cases where the use of IHC allowed us to achieve a conclusive diagnosis.

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Corlan, Ion Virgil, Adelina Cheveresan, Delia Berceanu Vaduva, Cristian Nica, Alin Faur, Ramona Camelia Rumel, and Ramona Amina Popovici. "Characterization of Healthy and Tumor Oral Cell Lines of Human Origin. The preliminary stage in the assessment of relevant chemical compounds with impact on dentistry." Revista de Chimie 69, no. 10 (November 15, 2018): 2889–94. http://dx.doi.org/10.37358/rc.18.10.6647.

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The present study was aimed to evaluate the confluence percentage of three oral cell lines, namely primary gingival keratinocytes (PGK), primary gingival fibroblasts (HGF) and tongue squamous cell carcinoma (SCC-4). All cells have been monitored at different passages for 21 days. Evaluation of confluence percentage reveals the fact that primary gingival keratinocytes and tongue squamous cell carcinoma at small passages requires a period of about two weeks to reach a confluence of approximately 80% while for the gingival fibroblasts a period of about three times smaller is satisfactory.

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MAFRA, RODRIGO PORPINO, MARIANNA SAMPAIO SERPA, AMANDA KATARINNY GOES GONZAGA, RODRIGO GADELHA VASCONCELOS, MARCELO GADELHA VASCONCELOS, ÉRICKA JANINE DANTAS DA SILVEIRA, and LEÃO PEREIRA PINTO. "CORRELATION OF MAST CELLS AND LYMPHANGIOGENESIS IN ORAL TONGUE SQUAMOUS CELL CARCINOMA." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 124, no. 2 (August 2017): e125-e126. http://dx.doi.org/10.1016/j.oooo.2017.05.332.

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Motiee-Langroudi, M., A. Amali, B. Saedi, H. Emami, F. Ensani, A. Lotfi, and M. Rabbani Anari. "Occult level IV metastases in clinically node-negative patients with oral tongue squamous cell carcinoma." Journal of Laryngology & Otology 130, no. 5 (April 20, 2016): 474–77. http://dx.doi.org/10.1017/s0022215116000931.

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AbstractObjective:The present study was conducted to determine the rate of level IV lymph node involvement among node-negative (N0) necks in patients with squamous cell carcinoma of the tongue.Methods:The study comprised 32 patients with squamous cell carcinoma of the tongue, with tumour–node–metastasis staging of T1–3N0M0, who were admitted to the Otolaryngology Department at Tehran University of Medical Sciences from March 2012 to March 2014. After a complete diagnostic evaluation, wide primary tumour excision (with 1.5–2 cm margins) and extended supraomohyoid neck dissection (levels I–IV) were accomplished.Results:Occult metastasis was found in 28 per cent of the patients. Level I, II and III metastases were the most common (18.75, 18.75 and 15.62 per cent, respectively). Level IV metastasis was found in 6.25 per cent of patients.Conclusion:Supraomohyoid neck dissection appears to be an appropriate treatment for N0 tongue squamous cell carcinoma and there is no need for level IV lymph node dissection in a N0 patient.

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Ahmed, Sadaf, Montasir Junaid, Sohail Awan, Maliha Kazi, Hareem Khan, and Sohail Halim. "Frequency of Cervical Nodal Metastasis in Early-Stage Squamous Cell Carcinoma of the Tongue." International Archives of Otorhinolaryngology 22, no. 02 (June 6, 2017): 136–40. http://dx.doi.org/10.1055/s-0037-1603626.

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Introduction Oral cavity carcinoma is an aggressive tumor, with the tongue being one of the most common subsites of involvement. Surgery is a gold standard method of dealing with advanced-stage tumors. However, for early-stage carcinomas of the tongue, the management remains controversial. Several studies have indicated that early-stage cancers have a high chance of occult cervical node metastasis, which, if left untreated, can greatly affect the prognosis. Certain parameters can help identify patients with occult cervical node metastases, and can avoid unnecessary neck dissection in node negative patients. Tumor thickness is one such objective parameter. Objective To estimate the frequency of cervical lymph node metastasis in patients with early-stage, node-negative (N0) squamous cell carcinoma of the tongue. Methods In-patient hospital data was reviewed from January 2013 until March 2014, and 78 patients who underwent primary resection of the tumor and neck dissection for biopsy-proven, early stage squamous cell carcinoma of the tongue were included. Data such as tumor thickness, tumor differentiation and presence of occult nodal metastasis in the surgical specimen were gathered from the histopathology reports. The frequency of subclinical cervical lymph node metastasis in patients with early-stage squamous cell carcinoma of the tongue was estimated. Results A total of 69% of the patients with tumor thicknesses > 5 mm had tumor metastases in the neck nodes, while 100% of the patients with tumor thicknesses < 5 mm had no neck nodal metastasis. Conclusion A tumor thickness > 5 mm is significantly associated with subclinical metastasis, and prophylactic neck dissection is warranted in such cases.

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Ashtiani, M. T. K., N. Yazdani, and A. Kouhi. "P1.64. Synchronous carcinoma of oral mucosa in the early stage oral tongue squamous cell carcinoma." Oral Oncology Supplement 3, no. 1 (July 2009): 144. http://dx.doi.org/10.1016/j.oos.2009.06.350.

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Monasebian, Douglas M., and James D. Ruskin. "Flow cytometric analysis of squamous cell carcinoma of the tongue." Journal of Oral and Maxillofacial Surgery 52, no. 6 (June 1994): 574–78. http://dx.doi.org/10.1016/0278-2391(94)90092-2.

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Mailiza, Fitria, and Rifani Rifani. "Chronic Ulcer Mimicking Oral Squamous Cell Carcinoma (A Case Report)." B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah 6, no. 1 (July 22, 2019): 49–55. http://dx.doi.org/10.33854/jbd.v6i1.211.

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Introduction: Chronic ulcers are considered as the most common ulcerations and can be differentiated with oral squamous cell carcinoma (OSCC) by the presentation of its features. OSCC define as a malignant epithelial neoplasm and the most common neoplasm of the oral cavity. OSCC appears as a mixed white or reddish proliferative growth-like lesion from chronic trauma. Case and management: A 50 years old female came with a painful non-healing ulcer on the lateral right side of the tongue which had been exist since 6 months prior. There had been a gradual increase in the size of the ulcer over the past 6 months. The patient did not have any sistemic disease or bad habits such as chewing or smoking and did not consume alcohol either. Based on the examination, the right submandibular lymphnodes were palpable, tender, firmed and mobile. And there was also a single oval-shaped ulcer with irregular border on the lateral aspect of the tongue in parallel with fractured and decayed lower first molar. The ulcer size was 2x1 cm in diameter, with the base covered by yellowish pseudomembran slough with indurated border. The grinding of the sharp cusp of the tooth was done, followed by the prescription of multivitamins, antibacterial mouthwash and topical corticosteroid. She was also referred to have routine blood test done. She came for the second visit after 14 days, showing improvement of the ulcer. The blood test showed no abnormal values. Discussion: Based on clinical features, the presented lesion was mimicking OSCC. According to the patient’s history taking, clinical examination and appropriate investigation, the patient was diagnosed with traumatic ulcer. Ulcer resolves and heals on the removal of causative factors. Conclusion: Chronic ulcer is one of the most common solitary ulcer presenting in the oral cavity that mimicking OSCC by the presentation of its features. In this reported case, the ulcer arises due to its constant contact with lateral right of the tongue Improvement during the treatment by eliminating suspected risk factors can ruled out the possibility of OSCC thus prevent the unnecessary treatment.

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Lakshminarayana, G., Chandrashekar Mani, Ann Kurian, and Annapurneshwari. "Predictors of recurrence in early stage oral tongue squamous cell carcinoma." Journal of Orofacial Sciences 7, no. 2 (2015): 86. http://dx.doi.org/10.4103/0975-8844.169753.

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Liu, Lijun, Xiaofeng Wang, and Wenzhang Ge. "EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma." Medical Science Monitor 24 (October 9, 2018): 7213–22. http://dx.doi.org/10.12659/msm.910909.

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