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Huang, Meineng, Sheng Jiang, Tong Chen, Xu Han, Xinyu Yang, Zhizen Quan, Yang Yuan, et al. "Preparation and Evaluation of the Curative Effect of Blue Shark (Prionace glauca) Skin Collagen Composite Gel in a Rat Oral Ulcers Model." Journal of Biomaterials and Tissue Engineering 11, no. 10 (October 1, 2021): 1924–31. http://dx.doi.org/10.1166/jbt.2021.2787.
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Objective: To evaluate the curative effect of blue shark skin collagen composite gel on oral mucosal ulcer using the rat oral ulcers model stimulated by glacial acetic acid. Methods: Collagen from blue shark skin was isolated and physiochemically characterized by FTIR, SDS-PAGE and scanning electron microscopy (SEM). Seventy standard male rats were divided into seven groups. The surface and the area of the ulcer were observed and calculated daily. After 12 days of administration, rats in the model group and the control group were killed and the ulcer and surrounding tissues were cut to pieces about one mm3 size. The specimens were stained with 10% formalin solution, paraffinembedded sections, HE staining and light microscope were used to observe the histopathological changes in ulcer tissues. Results: The high-dose group had the fastest ulcer healing effects after 12 days of treatment with blue shark skin collagen composite gel. The composite gel was found to significantly accelerate the healing of oral ulcers in a dose-dependent manner. Conclusion: The blue shark skin collagen composite gel in this study may be a good biomedical material candidate for the treatment of oral ulcers in the near future. Potential of other marine fish skin collagen comples on healing oral ulcers should be also considered.
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Hatemi, G., B. Yurttas, Z. Kutlubay, T. Cote, Ş. B. Derkunt, Y. Yazici, and H. Yazici. "SAT0260 PENTOXYFILLINE GEL FOR ORAL ULCERS IN PATIENTS WITH BEHÇET’S SYNDROME." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1072.1–1073. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5610.
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Background:Oral ulcers, the hallmark lesion of Behçet’s syndrome (BS) can be disabling and impair eating, drinking and speaking. Despite recent advances in systemic medications for the treatment of oral ulcers, some patients do not achieve complete remission. Topical agents may help such patients by decreasing the pain and duration of oral ulcers. Pentoxyfilline (PTX) is a methylxanthine derivative that inhibits phosphodiesterase and is thought to have immunomodulatory effects in addition to improving blood flow which is its main reason for use in peripheral vascular disorders.Objectives:The aim of this study is to assess the efficacy and safety of PTX gel for oral ulcers in patients with BS. We also aimed to explore the best tools for the assessment of treatment response to topical agents in randomized controlled trials (Clinicaltrial.gov ID: NCT 03888846).Methods:This was an open-label, randomized, parallel group study comparing PTX gel in addition to colchicine (PTX-COL) with colchicine alone (COL). Patients with BS who were treated with colchicine and not using any other systemic medications for BS, having at least one oral ulcer that appeared during the last 48 hours were included. PTX 5% gel with a dose of 1000 mg/day was applied in 4 divided doses per day for 14 days. Patients were contacted daily for 14 consecutive days. Photographs were taken every 24 - 48 hours and graphical processing software was used to calculate the area of the index ulcer. Duration of the index ulcer, time to start of index ulcer shrinkage, time to 50% reduction in oral ulcer pain on a 10 mm visual analog scale (VAS), change from baseline in the area of the index ulcer over time, total number of oral ulcers and adverse events were evaluated.Results:A total of 41 patients were randomized, 39 patients (18 in the PTX-COL group and 21 in the COL group) completed the study and 2 patients in PTX-COL group withdrew from the study due to unacceptable dysgeusia and nausea. Mean duration of index ulcer, time to start of index ulcer shrinkage, time to 50% reduction in oral ulcer pain, and number of patients with no detectable ulcers on day 4 in each group were lower in the PTX-COL group as presented in the Table. Change from baseline in the area of index ulcer and pain score over time is shown in the Figure. There were no serious adverse events. Fifteen (75%) patients reported nausea, 11 (55%) reported dysgeusia and 2 reported vomitting in the PTX-COL group, while 2 patients (10%) reported nausea in the COL group.Conclusion:This pilot phase 2 open label, randomized controlled study supports the hypothesis that topical PTX in addition to colchicine accelerates the healing of BS oral ulcers compared to colchicine alone. A phase 3 controlled study with a higher number of patients is planned with improving the taste for tolerability of the product.Disclosure of Interests:Gulen Hatemi Grant/research support from: BMS, Celgene Corporation, Silk Road Therapeutics – grant/research support, Consultant of: Bayer, Eli Lilly – consultant, Speakers bureau: AbbVie, Mustafa Nevzat, Novartis, UCB – speaker, Berna Yurttas: None declared, Zekayi Kutlubay: None declared, Tim Cote Employee of: Silk Road Therapeutics is in Washington, DC, USA, Şemsi Burak Derkunt Employee of: Silk Road Therapeutics is in Washington, DC, USA, Yusuf Yazici: None declared, Hasan Yazici: None declared
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Alamoudi, N. M., E. A. ElAshiry, N. M. Farsi, D. A. El Derwi, and H. M. Atta. "Treatment of Oral Ulcers in Dogs Using Adipose Tissue-Derived Mesenchymal Stem Cells." Journal of Clinical Pediatric Dentistry 38, no. 3 (April 2014): 231–40. http://dx.doi.org/10.17796/1053-4628-38.3.231.
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Aim:Adipose tissue Derived Mesenchymal Stem cells (ADMSCs) represent a promising tool for new clinical concepts in supporting cellular therapy. The goal of this study was to investigate the effects of ADMSCs transplantation on oral ulcer healing in dogs.Study design:Mesenchymal stem cells were isolated from adipose tissues of dogs obtained by suction-assisted lipectomy (liposuction), by dish adherence and were expanded in culture. Oral ulcers were induced by topical application of formocresol in the oral cavity of 18 dogs. The dogs were classified into 3 groups. Either autologousADMSCs, Corticosteriod (Dexamethasone) or vehicle (saline) was injected. The healing process of the ulcer was monitored histopathologically. Gene expression of vascular endothelial growth factor (VEGF),platelets derived growth factor (PDGF),epidermal growth factor (EGF) and collagen was assessed in biopsies obtained from all ulcers “as healing markers”, by real time polymerase chain reaction (PCR). Results:ADMSCs group showed significantly accelerated oral ulcer healing compared with the Dexamethasone and control groups. There was increased expression of VEGF, PDGF,EGF and collagen genes in ADMSCs-treated ulcers compared with Dexamethasone and controls. Conclusion:ADMSCs transplantation may help accelerate oral ulcer healing, possibly through the induction of angiogenesis by VEGF and PDGF, as well as epithelial and connective tissue proliferation as evidenced by increased EGF and collagen gene expression.
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Kongpuckdee, Sonsawan, Suwipa Ungphaiboon, Supreedee Sungkharak, Narubodee Phadoongsombut, and Sirima Mahattanadul. "Efficacy of An Aqueous Morinda citrifolia Fruit Extract-Phytosome Gel in Treating Oral Inflammatory Ulcer in Rabbit Model." Current Pharmaceutical Biotechnology 21, no. 15 (December 23, 2020): 1699–710. http://dx.doi.org/10.2174/1389201021666200711151925.
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Background: Oral inflammatory ulcers are one of the common complaints of patients attending out-patient clinics. Previous in vivo studies had shown that an Aqueous M. citrifolia Fruit Extract (AMFE) possessed anti-inflammatory and ulcer healing activities. Therefore, a standardized topical bioadhesive gel containing AMFE-phytosome was developed and determined for its oral ulcer healing efficacy in a rabbit model. Methods: The AMFE phytosome (AMFE-P) was prepared by a complexation method with the required amount of AMFE: Phosphatidylcholine: Tween 80 to weigh ratio of 2:1:0.2. Poloxamer 407 was used as a gelling agent. The oral ulcer was induced in male New Zealand white rabbits by topical application of acetic acid. Each test compound was applied to the ulcer for 10 days beginning on the second day after the ulcer induction. Complete ulcer healing on the specimen obtained on day 12 was observed histologically using the histological scoring protocol. Results: The optimized gel containing AMFE-P equivalent to AMFE 10%w/w (10%AMFE-P gel) showed the best bioadhesive gel quality, a smooth and homogeneous texture with an optimum viscosity and pH range used in human oral cavity, a good physical and chemical stability and the highest percentage cumulative release of total phenolic and scopoletin content. It was found that a daily application of 10% AMFE-P gel exerted a superior ulcer healing efficacy and a significantly rapid ulcer healing process than a twice daily application of topical gel containing AMFE 10%w/w or chlorhexidine 0.2%. Conclusion: These findings demonstrated that 10% AMFE-P gel has potential as a safe and effective alternative therapeutic agent for oral ulcers.
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Nodai, T., S. Hitomi, K. Ono, C. Masaki, N. Harano, A. Morii, M. Sago-Ito, et al. "Endothelin-1 Elicits TRP-Mediated Pain in an Acid-Induced Oral Ulcer Model." Journal of Dental Research 97, no. 8 (March 8, 2018): 901–8. http://dx.doi.org/10.1177/0022034518762381.
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Oral ulcer is the most common oral disease and leads to pain during meals and speaking, reducing the quality of life of patients. Recent evidence using animal models suggests that oral ulcers induce cyclooxygenase-dependent spontaneous pain and cyclooxygenase-independent mechanical allodynia. Endothelin-1 is upregulated in oral mucosal inflammation, although it has not been shown to induce pain in oral ulcers. In the present study, we investigated the involvement of endothelin-1 signaling with oral ulcer–induced pain using our proprietary assay system in conscious rats. Endothelin-1 was significantly upregulated in oral ulcers experimentally induced by topical acetic acid treatment, while endothelin-1 production was suppressed by antibacterial pretreatment. Spontaneous nociceptive behavior in oral ulcer model rats was inhibited by swab applications of BQ-788 (ETB receptor antagonist), ONO-8711 (prostanoid receptor EP1 antagonist), and HC-030031 (TRPA1 antagonist). Prostaglandin E2 production in the ulcers was suppressed by BQ-788. Mechanical allodynia in the model was inhibited not only by BQ-788 and HC-030031 but also by BQ-123 (ETA receptor antagonist), SB-366791 (TRPV1 antagonist), and RN-1734 (TRPV4 antagonist). In naive rats, submucosal injection of endothelin-1 caused mechanical allodynia that was sensitive to HC-030031 and SB-366791 but not to RN-1734. These results suggest that endothelin-1 production following oral bacterial invasion via ulcerative regions elicits TRPA1-mediated spontaneous pain. This pain likely occurs through an indirect route that involves ETB receptor-accelerated prostanoid production. Endothelin-1 elicits directly TRPA1- and TRPV1-mediated mechanical allodynia via both ETA and ETB receptors on nociceptive fibers. The TRPV4-mediated allodynia component seems to be independent of endothelin signaling. These findings highlight the potential of endothelin signaling blockers as effective analgesic approaches for oral ulcer patients.
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Thompson, Lester D. R. "Oral traumatic ulcer." Ear, Nose & Throat Journal 90, no. 11 (November 2011): 518–34. http://dx.doi.org/10.1177/014556131109001109.
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Alamoudi, N. M., E. A. El Ashiry, N. M. Farsi, D. A. El Derwi, and H. M. Atta. "Treatment of Oral Ulcers in Dogs Using Adipose Tissue-Derived Mesenchymal Stem Cells." Journal of Clinical Pediatric Dentistry 38, no. 3 (April 1, 2014): 215–22. http://dx.doi.org/10.17796/jcpd.38.3.193115427jg6vl60.
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Aim: Adipose tissue Derived Mesenchymal Stem cells (ADMSCs) represent a promising tool for new clinical concepts in supporting cellular therapy. The goal of this study was to investigate the effects of ADMSCs transplantation on oral ulcer healing in dogs. Study design: Mesenchymal stem cells were isolated from adipose tissues of dogs obtained by suction-assisted lipectomy (liposuction), by dish adherence and were expanded in culture. Oral ulcers were induced by topical application of formocresol in the oral cavity of 18 dogs. The dogs were classified into 3 groups. Either autologous ADMSCs, Corticosteriod (Dexamethasone) or vehicle (saline) was injected. The healing process of the ulcer was monitored histopathologically. Gene expression of vascular endothelial growth factor (VEGF), platelets derived growth factor (PDGF), epidermal growth factor (EGF) and collagen was assessed in biopsies obtained from all ulcers ‘’as healing markers’’, by real time polymerase chain reaction (PCR). Results: ADMSCs group showed significantly accelerated oral ulcer healing compared with the Dexamethasone and control groups. There was increased expression of VEGF, PDGF, EGF and collagen genes in ADMSCs-treated ulcers compared with Dexamethasone and controls. Conclusion: ADMSCs transplantation may help accelerate oral ulcer healing, possibly through the induction of angiogenesis by VEGF and PDGF, as well as epithelial and connective tissue proliferation as evidenced by increased EGF and collagen gene expression.
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Minhas, Sadia, Aniqa Sajjad, Muhammad Kashif, Farooq Taj, Hamed Alwadaani, and Zohaib Khurshid. "Oral Ulcers Presentation in Systemic Diseases: An Update." Open Access Macedonian Journal of Medical Sciences 7, no. 19 (October 10, 2019): 3341–47. http://dx.doi.org/10.3889/oamjms.2019.689.
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BACKGROUND: Diagnosis of oral ulceration is always challenging and has been the source of difficulty because of the remarkable overlap in their clinical presentations.
AIM: The objective of this review article is to provide updated knowledge and systemic approach regarding oral ulcers diagnosis depending upon clinical picture while excluding the other causative causes.
METHODS: For this, specialised databases and search engines involving Science Direct, Medline Plus, Scopus, PubMed and authentic textbooks were used to search topics related to the keywords such as oral ulcer, oral infections, vesiculobullous lesion, traumatic ulcer, systematic disease and stomatitis. Associated articles published from 1995 to 2019 in both dental and medical journals including the case reports, case series, original articles and reviews were considered.
RESULTS: The compilation of the significant data reveals that ulcers can be classified according to (i) duration of onset, (ii) number of ulcers and (iii) etiological factors. Causation of oral ulcers varies from slight trauma to underlying systemic diseases and malignancies.
CONCLUSION: Oral manifestations must be acknowledged for precise diagnosis and appropriate treatment.
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Lakshana S, Vijayalakshmi S, Dinakar J, and Asok Kumar K. "Effect of Tagetes erecta flower and leaf extract gel on oxidative stress and antioxidant levels in oral ulcer condition." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (July 6, 2020): 2979–85. http://dx.doi.org/10.26452/ijrps.v11i3.2391.
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An oral ulcer is described by repeated or painful oral aphthae, in which oxidative stress apparently leads to its pathogenesis. The present study has been undertaken to evaluate the effects of fresh leaves and flowers of Tagetes erecta gel on oxidative stress and antioxidant levels on oral ulcer models in albino Wistar rats. The oral ulcer was induced by incision wound model and then treated with the Tagetes erecta flower and leaf extract gel for 7 days. The antioxidant activities of catalase (CAT), superoxide dismutase (SOD), the levels of glutathione (GSH) and malondialdehyde (MDA) were measured in rat buccal mucosal tissues. The antiulcer effects of Tagetes erecta leaf and flower extracts (2.5% and 5%) gel were intercompared with the standard drug, Triamcinolone. Ulcer induced rats exhibited elevated levels of MDA and reduced activity of SOD, GSH and CAT when compared to the control rats. The nonequilibrium levels of antioxidant were observed in rat mucosal tissues indicate that body’s antioxidant status was depleted with an oral ulcer. Tagetes erecta leaf and flower gel (5%) has been found to have higher significant antioxidant activity compared with ulcer induced rats by reducing the levels of MDA and by increasing the activities of SOD, GSH and CAT in response to oxidative stress due to induction of oral ulcers in a rat model. The findings thus justify the traditional use of Tagetes erecta to heal oral ulcer by increasing the antioxidant status and decreasing the free radical production.
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Warrier, Aravind, Maguluru Sruthi, and K. Anbarasi. "Comprehensive management of major aphthous ulcer." BMJ Case Reports 14, no. 5 (May 2021): e241010. http://dx.doi.org/10.1136/bcr-2020-241010.
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Recurrent aphthous ulcers are the most prevalent oral mucosal disease, but the subset major aphthous ulcer is a less frequent type. These ulcers are refractory, may persist for several weeks to months, and interfere with the normal state of health. The aetiology is multifactorial and so is the treatment. We present a case of an adolescent male patient reported with multiple oral ulcers. He developed three ulcers simultaneously and suffered for 10 months despite using topical medications prescribed by different dental practitioners. We executed a multidisciplinary treatment approach that resulted in a long-term disease-free state. The treatment methods followed in our case could be a successful model to implement by medical practitioners and oral physicians when the situation demands.
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Prathoshini, Manthra. "Management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements." Bioinformation 16, no. 12 (December 31, 2020): 992–98. http://dx.doi.org/10.6026/97320630016992.
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Recurrent Aphthous ulcers are the most common oral lesions among dental patients. The ulcers, which usually occur on the nonkeratinized oral mucosa, can cause considerable pain and may interfere with eating, speaking, and swallowing. Therefore, it is of interest to report data on the management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements. Case sheets of 76 patients who underwent treatment for recurrent aphthous ulcer between June 2019 and March 2020 at the Saveetha Dental College, India were used in this analysis. Data was analyzed using Chi square test at a P value < 0.05 that is statistically significant. Results show that topical anaesthetics in population (49%) were more effective that corticosteroids. Thus, topical anaesthetics are recommended for recurrent aphthous ulcer.
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Prathoshini, Manthra. "Management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements." Bioinformation 16, no. 12 (December 31, 2020): 992–98. http://dx.doi.org/10.6026/97320630016992.
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Recurrent Aphthous ulcers are the most common oral lesions among dental patients. The ulcers, which usually occur on the nonkeratinized oral mucosa, can cause considerable pain and may interfere with eating, speaking, and swallowing. Therefore, it is of interest to report data on the management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements. Case sheets of 76 patients who underwent treatment for recurrent aphthous ulcer between June 2019 and March 2020 at the Saveetha Dental College, India were used in this analysis. Data was analyzed using Chi square test at a P value < 0.05 that is statistically significant. Results show that topical anaesthetics in population (49%) were more effective that corticosteroids. Thus, topical anaesthetics are recommended for recurrent aphthous ulcer.
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Nzhad Mustafa, Bero, and Ali Fakhree Alzubaidee. "Comparative Evaluation of The Efficacy of Topical Hyaluronic Acid ( 0.2%) and Topical Triamcinolone Acetonide( 0.1%) in The Treatment of Recurrent Aphthous Stomatitis." Diyala Journal of Medicine 19, no. 2 (December 15, 2020): 107–17. http://dx.doi.org/10.26505/djm.19025470628.
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Background: Recurrent aphthous ulcers are the most common oral lesion. They are classified into minor, major, and herpetiform ulcers. More than 85% of recurrent aphthous stomatitis presents as a minor ulcer. Hyaluronic acid is a biomaterial and it is a major carbohydrate component that can be found in many tissues and recently introduced as an alternative approach to enhance wound healing. Triamcinolone acetonide is a synthetic corticosteroid and it has two forms for topical use cream (0.1%) and ointment (0.1%). Objective: To make a comparison between the effectiveness of hyaluronic acid (0.2%) and triamcinolone acetonide (0.1) in the management of recurrent aphthous ulcer. Patients and Methods: We recruited eighty patients who had a history of recurrent aphthous stomatitis and when presented with current oral ulcer and randomly divided into two groups, one group received hyaluronic acid, and the other group received triamcinolone acetonide. The instruction was given to all patients to apply the agent to the aphthous ulcer 4 times per day for 6 days (day 0 to day 6). The severity of pain was assessed by using VAS and the change of the ulcer surface area measured. Results: Eighty patients with aphthous ulcers have participated in the study, 43 were treated with hyaluronic acid, 37 were treated with triamcinolone acetonide. There was a significant difference between the two groups regarding ulcer surface and after three and six days, the diameter of the ulcer in the hyaluronic acid group was significantly reduced in comparison with those of the triamcinolone acetonide group (p < 0.001). Regarding VAS for pain, there was a significant difference after three and six days, hyaluronic acid group had significantly less VAS than those of the triamcinolone acetonide group (p = 0.004 and p < 0.001 respectively). Conclusion: Hyaluronic acid is more effective than triamcinolone acetonide when used in the treatment of recurrent oral ulcers in reducing pain and surface area of the ulcer. Keywords: Hyaluronic acid (HA), Triamcinolone acetonide (TA), Recurrent aphthous stomatitis (RAS), comparative evaluation
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Arwidasari, Annisya Ristie, Twi Agnita Cevanti, and Isidora Karsini Soewondo. "Effectiveness of Sargassum sp. ethanolic extract on traumatic ulcers healing in the labial mucosa of Wistar strain (Rattus norvegicus)." Padjadjaran Journal of Dentistry 31, no. 1 (March 31, 2019): 73. http://dx.doi.org/10.24198/pjd.vol31no1.16513.
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Introduction: Oral ulcer lesions are one of the most common lesions in the oral cavity. The prevalence of traumatic ulcers is quite high compared to other oral lesions. Brown algae, Sargassum sp. is one of the algae contains flavonoids, vitamin A, vitamin C, iron, and calcium, which play a role in wound healing and has economic value. This study was aimed to determine the effectiveness of Sargassum sp. ethanolic extract on traumatic ulcers healing in the labial mucosa of Wistar strain (Rattus norvegicus). Methods: 28 Wistar strain (Rattus norvegicus) weighed 150-200 grams. The samples were divided into 4 groups (K1, K2, P1, P2); each group consisted of 7 mice. K1 group was administered with Hydroxy Propyl Methyl Cellulose (HPMC), K2 was administered with 0.2% hyaluronic acid gel, P1 was administered with 50% Sargassum sp. extract gel, and P2 was administered with 75% Sargassum sp. extract gel. In each group, the ulcer was made on the mice labial mucosa; then the ulcer diameter was measured and observed on day 1 and day 7. Results: The mean diameter ± standard deviation of traumatic ulcer calculations were K1 (1.09 ± 0.40), K2 (1.81 ± 0.67), P1 (1.39 ± 0.43) and P2 (2.16 ± 0.49) respectively. One way ANOVA test results showed significant differences in K1, K2, P1, and P2 groups. Conclusion: Ethanol extract of Sargassum sp. is effective in accelerating the traumatic ulcers healing at the concentration of 75%.Keywords: Traumatic ulcer, Sargassum sp., wound healing.
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Rajlawat, B. P., J. Evans-Jones, A. Triantafyllou, E. Varga, and E. A. Field. "A solitary oral ulcer." Clinical and Experimental Dermatology 36, no. 2 (February 16, 2011): 217–19. http://dx.doi.org/10.1111/j.1365-2230.2010.03879.x.
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Murrell, George L. "Secondary syphilis oral ulcer." Otolaryngology–Head and Neck Surgery 140, no. 6 (June 2009): 942–43. http://dx.doi.org/10.1016/j.otohns.2009.01.011.
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Çakir, E. N., Y. Yenisoy, A. Kapusuz, K. Abacar, F. Alibaz-Oner, M. Yay, Ü. Karaçayli, et al. "AB0895-HPR A MODERATED MEDIATION ANALYSIS FOR POOR ORAL HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH BEHÇET’S DISEASE." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1471.1–1471. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3043.
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Background:Since oral ulcer is a common clinical manifestation, oral health-related quality of life (OHRQoL) is affected by the presence of oral ulcer poorly in patients with Behcet’s disease (BD).Objectives:The aim of the study was to examine associated factors for poor OHRQoL status to improve treatment outcomes in patients with BD.Methods:In this retrospective study, 339 BD patients (F/M: 179/160, mean age: 36,13±9,81 years) included. Data were collected by a structured questionnaire regarding treatment expectation, Oral Health Impact Profile-14 (OHIP-14) questionnaire for OHRQoL, oral ulcer activity, and disease severity score. Treatment expectation was coded by a 5-point Likert type scale (1: symptoms were completely cured vs 5: symptoms were worsened). OHIP-14 score was between “0 point (the best score)” and “56 points (the worst score)”. The disease severity score was calculated according to the organ involvement. Then, patients were categorised as mucocutaneous involvement (n=181) and severe organ involvement (n=158). After preliminary analysis, a Moderated Mediation analysis was carried out.Results:Oral ulcer activity was seen in 63,4% of the group (n=215). OHIP-14 score (22,05±16,47) was correlated with Treatment expectations (2,35±0,98) (r: 0,36 p=0.000) in the group. Poor scores of OHIP-14 and Treatment expectations were found in patients with active oral ulcers (mucocutaneous involvement: 27,56±14,55; 2,68±0,87, vs severe organ involvement: 28,51±17,25; 2,43±0,99) compared to those of inactive patients (mucocutaneous involvement: 13,38±12,23; 1,81±0,73 vs severe organ involvement: 8,79±10,19; 1,85±1,02) (p=0.000 for all). Patients with active oral ulcers were younger (35,09±9,52) than the others (39,57±10,06) in the mucocutaneous involvement group (p=0.0011) whereas a similar relation was not seen in the severe organ involvement (p=0.233).In the moderated mediation analysis, it was found that OHIP-14 score was increased by the presence of oral ulcer in the direct path (p=0.0000) and the negative Expectation of the treatment as a first mediator (p = 0.0001) in the indirect path. Oral ulcer activity was associated with younger patients (p=0.0039). This effect was seen especially in patients with mucocutaneous involvement that had a moderator effect (p=0.0040). In addition, age was found to be a second mediator for the poor OHIP-14 score (p = 0.0053). Mediators and the moderator were found to effective for OHIP-14 score a bootstrap analysis with 5000 replications.Conclusion:OHRQoL was affected by oral ulcer activity and poor treatment expectations. Age was also found to be another critical factor for OHRQoL.Disclosure of Interests:None declared
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Anggraeni, Dian, Kamaluddin Kamaluddin, and Theodorus Theodorus. "Effectiveness of Garlic Water Extract Gel (Allium sativum. L) Against Necrotic Factor Alfa Tumors and Mouth Ulcer Diameter in Wistar White Male Rats." Biomedical Journal of Indonesia 6, no. 1 (May 3, 2020): 27–34. http://dx.doi.org/10.32539/bji.v6i1.7970.
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Oral ulcers are pathological conditions that are characterized by loss of epithelial tissue, causing inflammation. During inflammation, the inflammatory mediator is TNF will increase. Therefore, drugs are needed to suppress TNF-levels to suppress inflammation. One of the herbal ingredients that can suppress inflammation is garlic. In vivo laboratory experimental research with pre-post systems. The samples used were 36 male Wistar white rats divided into 6 groups (6 individuals / groups), namely the group without drug treatment (as pre-treatment data), negative control group namely HPMC gel base, positive control given benzydamin, group treatment I was given a garlic water extract gel 20%, treatment group II was given a garlic water extract gel 40%, treatment group III were given a garlic water extract gel 80%. The drug is given topically 2 times a day for 4 days. Making oral ulcers is done by placing filter paper that has been soaked in a 50% acetic acid solution in the labial area of the mandibular gingival tissue. Measurement of oral ulcers was performed on the 1st day after the manufacture of oral ulcers and the 5th day. On the 5th day all the mice were sacrificed to be taken gingival tissue and TNF-levels were measured. using ELISA. Data analysis using SPSS version 24 and One Way Anova test with 5% specification followed by Post Hoc Test using LSD test and Games Howell. Analysis using One Way Anova showed that there were significant differences in TNF-levels and the diameter of the oral ulcer (p <0.05) between groups which indicated that the garlic water extract gel applied in the area of the oral ulcer affected TNF levels. and the diameter of the oral ulcer. LSD test results showed that 80% effective garlic water extract gel significantly reduced TNF levels. (p <0.05). Games Howell test results showed that 20%, 40% and 80% garlic water extract gel had the same effectiveness as benzydamin in decreasing the diameter of oral ulcer. Garlic water extract gel (Allium sativum. L) concentration was 80% more effective than benzydamin for decreasing TNF levels Garlic water extract gel (Allium sativum. L) concentrations of 20%, 40% and 80% are as effective as benzydamin in reducing the diameter of oral ulcers in male wistar strain rats.
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Mailiza, Fitria, and Rifani Rifani. "Chronic Ulcer Mimicking Oral Squamous Cell Carcinoma (A Case Report)." B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah 6, no. 1 (July 22, 2019): 49–55. http://dx.doi.org/10.33854/jbd.v6i1.211.
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Introduction: Chronic ulcers are considered as the most common ulcerations and can be differentiated with oral squamous cell carcinoma (OSCC) by the presentation of its features. OSCC define as a malignant epithelial neoplasm and the most common neoplasm of the oral cavity. OSCC appears as a mixed white or reddish proliferative growth-like lesion from chronic trauma. Case and management: A 50 years old female came with a painful non-healing ulcer on the lateral right side of the tongue which had been exist since 6 months prior. There had been a gradual increase in the size of the ulcer over the past 6 months. The patient did not have any sistemic disease or bad habits such as chewing or smoking and did not consume alcohol either. Based on the examination, the right submandibular lymphnodes were palpable, tender, firmed and mobile. And there was also a single oval-shaped ulcer with irregular border on the lateral aspect of the tongue in parallel with fractured and decayed lower first molar. The ulcer size was 2x1 cm in diameter, with the base covered by yellowish pseudomembran slough with indurated border. The grinding of the sharp cusp of the tooth was done, followed by the prescription of multivitamins, antibacterial mouthwash and topical corticosteroid. She was also referred to have routine blood test done. She came for the second visit after 14 days, showing improvement of the ulcer. The blood test showed no abnormal values. Discussion: Based on clinical features, the presented lesion was mimicking OSCC. According to the patient’s history taking, clinical examination and appropriate investigation, the patient was diagnosed with traumatic ulcer. Ulcer resolves and heals on the removal of causative factors. Conclusion: Chronic ulcer is one of the most common solitary ulcer presenting in the oral cavity that mimicking OSCC by the presentation of its features. In this reported case, the ulcer arises due to its constant contact with lateral right of the tongue Improvement during the treatment by eliminating suspected risk factors can ruled out the possibility of OSCC thus prevent the unnecessary treatment.
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Rashid, Sulthan Al, Syed Ziaur Rahman, and Saif Khan. "Comparative study for safety and efficacy of a novel folic acid formulation gel with 0.1% triamcinolone acetonide paste in experimentally induced oral ulcer." Indian Journal of Physiology and Pharmacology 65 (June 2, 2021): 39–44. http://dx.doi.org/10.25259/ijpp_11_2021.
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Objectives: The objective of the present study was to evaluate the efficacy and safety of 0.1% novel folic acid gel in blunt dental instrument-induced oral ulcer in animal models (both rats and rabbits). Materials and Methods: The study was conducted in the Experimental Laboratory, Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University. Animals were randomly divided into three interventional groups, namely Group 1 (folic acid gel), Group 2 (triamcinolone oromucosal paste) and Group 3 (control). We created a linear oral ulcer of 5 mm with the blunt dental instrument in both rats and rabbits. Each group consists of 10 animals (6 rats + 4 rabbits). Group 1 received test drug 0.1% novel folic acid gel formulated by us, Group 2 was positive control and received standard local drug 0.1% Kenacort triamcinolone oromucosal paste and Group 3 served as a negative control group where no treatment was given. Results: No untoward reaction was observed on the irritancy test. Kruskal–Wallis test applied for comparison of results. After 1 week of post-ulcer induction, there was a marked improvement in healing of oral ulcers in both Group 1 and Group 2, but more statistically significant healing was seen in Group 1 (folic acid gel). Both Groups 1 and 2 showed steady improvement in the healing of oral ulcers as compared to their pre-treated values and again were more marked in Group 1. Conclusion: Local folic acid gel supplementation was safe and had shown to augment oral ulcer healing in rats and rabbit’s animal models.
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Khalid, Basil, Aeeza Malik, Sharina Naz, Marium Aftab, Sidra Akram, and Malik Saleem Shaukat. "Efficacy of Coconut Milk on Healing of Oral Ulcers in Experimental Model; A Comparative Study." Journal of the Pakistan Dental Association 29, no. 04 (October 28, 2020): 211–16. http://dx.doi.org/10.25301/jpda.294.211.
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OBJECTIVE: This study was carried out to observe the morphological changes in healing of oral mucosal ulcers in experimental animals by applying coconut milk. METHODOLOGY: This experimental study was spanned over one month. It was carried out at animal experimental lab of University of Health Sciences Lahore, Pakistan. A total of 30 rabbits were divided into 2 groups (Group A & B, control & experimental respectively). Oral ulcers were induced in all the rabbits by using 4mm diameter punch biopsy apparatus through standard protocol. Normal healing in Control group was compared with the healing effects of medicament (coconut milk) which was applied topically thrice daily for fourteen days in Experimental group. Biopsies from both the groups were taken on 1, 4th, 7th and 14th day to see gross morphological as well as histological changes. RESULTS: Effects of coconut milk on healing of oral ulcers in experimental group, showed a sharp contrast with that of control group (p=0.001) especially on day 7th where maximum healing was induced by coconut milk. CONCLUSIONS: Coconut milk enhanced the healing of oral ulcers. Coconut milk has proved far superior healing effects on oral mucosa and therefore recommended as a natural healing medicament to be used as an alternate ulcer healing agent which is easily available, safe and inexpensive. KEYWORDS: Coconut milk, healing medicament, histopathology, oral ulcer HOW TO CITE: Khalid B, Malik A, Naz S, Aftab M, Akram S, Shaukat MS. Efficacy of coconut milk on healing of oral ulcers in experimental model; A comparative study. J Pak Dent Assoc 2020;29(4):211-216.
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Nagaraj, Vezhavendhan, Shanthi Sashykumar, Stalin Viswanathan, and Sathish Kumar. "Multiple oral ulcers leading to diagnosis of pulmonary tuberculosis." European Journal of Dentistry 07, no. 02 (April 2013): 243–45. http://dx.doi.org/10.4103/1305-7456.110197.
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ABSTRACTWe report a 47 year old man who presented with painful non-healing tongue ulcers of 3 months duration.Examination revealed an additional buccal ulcer that he was unaware of. Histopathology of the ulcers showed caseation necrosis. Following this report, chest radiography and sputum microscopy performed revealed pulmonary tuberculosis. From this case-study, one should be aware of coexisting pulmonary tuberculosis in patients with chronic non-healing oral ulcers, both for diagnosis as well as prevention of transmission through respiratory droplets.
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Freitas, Cristina Setim, Cristiane Hatsuko Baggio, Samanta Luiza Araújo, and Maria Consuelo Andrade Marques. "Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers." Brazilian Archives of Biology and Technology 51, no. 4 (August 2008): 479–83. http://dx.doi.org/10.1590/s1516-89132008000400005.
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The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral route. The administration of the AEP did not prevent ulcers formation. However, the AEP increased of the healing process of previously induced ulcers. The results suggest that AEP chronically administered promote an increase of tissue healing, after the damage induced by acetic acid and the extract seemed to be destituted of toxic effects in the mice by the oral route.
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Stehlikova, Zuzana, Vojtech Tlaskal, Natalie Galanova, Radka Roubalova, Jakub Kreisinger, Jiri Dvorak, Petra Prochazkova, et al. "Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis." Microorganisms 7, no. 12 (December 1, 2019): 636. http://dx.doi.org/10.3390/microorganisms7120636.
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Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa, and it has been recently associated with bacterial and fungal dysbiosis. To study this link further, we investigated microbial shifts during RAS manifestation at an ulcer site, in its surroundings, and at an unaffected site, compared with healed mucosa in RAS patients and healthy controls. We sampled microbes from five distinct sites in the oral cavity. The one site with the most pronounced differences in microbial alpha and beta diversity between RAS patients and healthy controls was the lower labial mucosa. Detailed analysis of this particular oral site revealed strict association of the genus Selenomonas with healed mucosa of RAS patients, whereas the class Clostridia and genera Lachnoanaerobaculum, Cardiobacterium, Leptotrichia, and Fusobacterium were associated with the presence of an active ulcer. Furthermore, active ulcers were dominated by Malassezia, which were negatively correlated with Streptococcus and Haemophilus and positively correlated with Porphyromonas species. In addition, RAS patients showed increased serum levels of IgG against Mogibacterium timidum compared with healthy controls. Our study demonstrates that the composition of bacteria and fungi colonizing healthy oral mucosa is changed in active RAS ulcers, and that this alteration persists to some extent even after the ulcer is healed.
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Sari, Rina Kartika, Diah Savitri Ernawati, and Bagus Soebadi. "RECURRENT APHTHOUS STOMATITIS RELATED TO PSYCHOLOGICAL STRESS, FOOD ALLERGY AND GERD." ODONTO : Dental Journal 6 (July 11, 2019): 45. http://dx.doi.org/10.30659/odj.6.0.45-51.
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Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress and high anxiety. Skin Prick Test showed positive allergy to kapok, beef, chicken, cow milk, white egg, duck egg, shrimp, cob fish, milkfish, chocolate, and peanut. Ulcers treated with nonsteroid antiinflammation Aloe Vera gel and stress management by reading assignment method.Discussion: Psychological stress altered the immune system so oral mucosa prone to inflammation, and make the history of GERD getting worse. Stress causes cortisol secretion that changes the imbalance of proinflammatory and antiinflammatory cytokines. Oral mucosa becomes more susceptible to hypersensitivity. In addition, stress decreased oral and esophageal mucosa resistance to GERDConclusion: RAS triggered by psychological stress, allergy, and GERD. Treatment of RAS is by elimination predisposing factors to prevent recurrence.
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Nelonda, Revi, and Riani Setiadhi. "Management of chronic traumatic ulcer mimicking oral squamous cell carcinoma on the tongue." Dental Journal (Majalah Kedokteran Gigi) 51, no. 2 (June 30, 2018): 76. http://dx.doi.org/10.20473/j.djmkg.v51.i2.p76-80.
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Background: Traumatic ulcers represent the most common oral mucosal lesions that can be differentiated from oral squamous cell carcinoma (OSCC) by their clinical appearance. From a clinical perspective, OSCC may resemble a chronic traumatic ulcer (CTU) because the base of the CTU that is healing is filled with reddish-pink granulated tissue, similar to that in OSCC. Purpose: The aim of this case report is to provide information about the oral management of a CTU case that imitates OSCC. Case: A 30-year old female presented with a major, painful, non-healing ulcer located on the right lateral of the tongue for the previous two months. Approximately two years before, she had experienced a similar lesion on the tongue. Intra oral examination showed a 10mm x 5mm yellowish ulcer with a fibrous center, erythematous irregular-induration margin and concave yellow base. The 15th, 44th and 47th teeth were sharp and on occlusion caused trauma to the right lateral border of the tongue. Case management: Based on the clinical features, the lesion was imitating OSCC. After a case history review, clinical examination and appropriate investigation, the patient was diagnosed as suffering from a chronic traumatic ulcer. The primary treatment of traumatic ulcers involves eliminating etiological factors. As pharmacological therapy, a mixture of triamcinolone acetonide and 1mg dexamethasone tablet was administered in addition to folic acid and vitamin B12. Conclusion: Clinical presentation of traumatic lesions varies significantly and may, at times, be ambigous. It is important to immediately establish a correct diagnosis and implement prompt treatment of CTU lesions because they play a role at the oral carcinogenesis promotion stage.
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Tabra, S. A. A., and M. H. Abu-Zaid. "THU0322 EFFECTIVENESS OF COMBINED LOCAL COLCHICINE AND STEROIDS IN ORAL ULCERS OF BEHÇET’S DISEASE." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 390.1–391. http://dx.doi.org/10.1136/annrheumdis-2020-eular.221.
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Background:Behçet’s disease (BD) is a chronic, multi-system vasculitic disease. It is characterized with relapsing episodes of oro-genital ulcers accompanied by cutaneous lesions, ocular symptoms, arthropathy, vascular thrombosis, central nervous system, gastrointestinal & cardiopulmonary involvements. Oral ulcers are frequently the first disease manifestationOral and genital ulcers cause pain and interfere with the quality of life. They may lead to difficulty in swallowing and walking. Most of them can be managed with topical glucocorticoids. Up till now there is no study discussed the effect of combined local therapy on oral ulcers in BD.1,2Objectives:To evaluate the effectiveness of combined local therapy (colchicine, steroid, antibiotic and anesthetic) on oral ulcers in BDMethods:This study included 44 Patients who had Behçet’s disease (according to International Study Group criteria) with active oral ulcers (at least three times in the previous 12-month period) Patients were excluded if they had active major organ involvement in the last 6 months. Patients with depilating diseases also were excluded.Patients were randomly divided into two equal groups; group I received combined local therapy (lidocaine HCL 2.0% gel mixed with grinded tablet of 5 mg prednisone and grinded tablet of 0.6 mg colchicine). Group II received combine local therapy (lidocaine HCL 2.0% gel mixed with grinded tablet of 5 mg prednisone). Local treatments were applied to the lesions 3 times per day until healing of the ulcer (advised not to eat or drink for 30 minutes after application). All other topical medications were stopped during this study.All patients were assessed with Oral ulcer severity score (OUSS), Behçet’s Disease Quality of Life score (BD-QoL), Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36) at baseline and after 24 weeks.Results:Thirty eight patients had completed this study; (20 in Group I & 18 in Group II). There were no significant differences between the 2 groups in both demographic data &educational status. At baseline there was no significant difference between both groups regarding all assessment measures. There was significant improvement (P<0.05) in both groups regarding OUSS, BD-QoL, SF-36 after 24 weeks. There was significant better improvement (P<0.05) in group I than in group II in all assessment measures (except ulcer free periods and sites). The results of the study are summarized in table 1 & figure 1.Table 1.A comparison of the individual ulcer characteristics in both groups at baseline and after 24 weeksUlcercharacteristicsGroup I baselineGroup II baselineGroup I after 24 weeksGroup II after 24 weeksNumber13.6 ±3.512.9 ±2.38.2 ±1.5*¶10.3 ±1.7*Size11.8 ±3.312.5 ±2.47.6 ±1.8*¶9.6 ±1.2*Duration6.7 ±1.16.6 ±1.74.5 ±1.9*¶5.5 ±1.3*Ulcer-free period4.7 ±0.95.1 ±1.55.7 ±1.1*5.9 ±0.7*Pain8.7 ±1.28.6 ±1.45.3 ±1.5*¶6.7 ±1.1*Site4.9 ±0.85.1 ±1.23.8 ±0.6*4.2 ±0.9**Significant improvement after 24 weeks of the study¶Significant difference between the two studied groupsConclusion:Combined local therapy (colchicine, steroid, antibiotic and anesthetic) is an effective method in management of oral ulcers in BD.References:[1]Taylor J, Glenny AM, Walsh T, et al. Interventions for the management of oral ulcers in Behçet’s disease (Review). 2014;(9):CD011018.[2]Hatemi G, Mahr A, Ishigatsubo Y et al. Trial of Apremilast for Oral Ulcers in Behçet’s Syndrome. N Engl J Med. 2019; 381(20):1918-1928.Disclosure of Interests:None declared
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Salim, F., A. Joshi, and C. Hopkins. "Ulceration of the nasal dorsum: a rare cause?" Journal of Laryngology & Otology 128, no. 3 (January 28, 2014): 289–91. http://dx.doi.org/10.1017/s0022215113003629.
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AbstractIntroduction:Non-healing ulcers can be caused by a number of conditions, including vascular disease, diabetes, malignancy and some infections. Drug-related ulcers are rare, and a high index of clinical suspicion is required for diagnosis, in parallel with exclusion of more sinister underlying causes.Case report:We present a patient with a complex medical background, who had a 10-week history of a non-healing ulcer on his nasal bridge. Inflammatory, autoimmune and malignant causes for the ulcer were excluded by histopathology.Conclusion:Nicorandil was deemed to be the most likely cause for the patient's ulcer. Nicorandil is an anti-anginal medication known to cause oral ulceration and skin lesions in the perianal and peristomal regions and around surgical wounds. However, there are no previously reported cases of facial ulcers. The ulcer required surgical debridement and healed completely within six months, following discontinuation of nicorandil. This case highlights the importance of having a high index of clinical suspicion regarding non-healing ulcers, and of considering drugs as an aetiological factor, especially in patients with a complex medical background who are taking numerous medications.
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Revianti, Syamsulina, Puguh Bayu Prabowo, Lita Agustia, and Isidora Karsini. "Innovative Treatment Using Salmon Skin Extract as Topical Application for Traumatic Oral Ulcer Healing: Animal Models." Archives of Orofacial Sciences 16, Supp. 1 (September 22, 2021): 37–42. http://dx.doi.org/10.21315/aos2021.16.s1.7.
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Salmon skin extract contains high proline and hydroxyproline, and has been suggested as a potential topical agent for traumatic oral ulcer healing. The aim of this study was to evaluate the effect of salmon skin extract as traumatic oral ulcer healing. A total of 32 Wistar rats (200 g to 250 g) were distributed into four groups. Group 1 served as the control group (no treatment), Group 2 was topically treated with salmon skin extract agent 4%, Group 3 was topically treated with salmon skin extract agent 5%, and Group 4 was topically treated with salmon skin extract agent 6%. Traumatic ulcers at lip mucosa were performed in all rats and 0.1 ml salmon skin extract was applied on the ulcer twice daily for seven days. The animals were euthanised on the last day of treatment. Biopsy specimens were taken from the lip mucosa in all rats for epithelial thickness evaluation and the study for number of fibroblasts by histological analysis. Significant increase in epithelial thickness and the number of fibroblasts (p > 0.05) was observed in salmon skin extract treatment groups as compared to the control group. Salmon skin extract 6% treatment group had the highest epithelial thickness and the number of fibroblasts amongst the study groups. Salmon skin extract promises an innovative topical application treatment for traumatic oral ulcer healing. Salmon skin extract 6% was the most effective concentration for traumatic oral ulcer healing.
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Madurapperuma, Sandara Wayangi, Andra Hennadige Heshan Malinga Jayaweera, and Ruwan Duminda Jayasinghe. "Spontaneously Regressing Neonatal Oral Aphthous Ulceration of the Palate." Case Reports in Pediatrics 2021 (February 6, 2021): 1–3. http://dx.doi.org/10.1155/2021/6660302.
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Background. Neonatal oral aphthous ulceration of the palate also known as Bednar’s aphthae is not an uncommon presentation. They clinically present as spontaneously regressing, shallow, and symmetrical ulcers on the posterior palate of newborns from 2 days up to 6 weeks of age. Case Presentation. We, herein, report a case of a one-month-old baby girl who presented with an ulcer in the posterior palate and intermittent mild fever. The patient was admitted and monitored in the ward. Haematologic investigations disclosed features of ongoing infection. Nasogastric feeding was commenced to avoid any irritation of the ulcer, and glycerine was applied on the ulcer. Antibiotic therapy was continued because of the intermittent mild fever. The lesion healed spontaneously within one week, and fever subsided afterwards. Currently, the patient is faring healthily without any complications. Conclusion. Although Bednar’s aphthae is not a rare presentation, clinicians are often met with a diagnostic dilemma due to the alarming clinical presentation of this condition. Therefore, it leads to overinvestigation and overtreatment. With this case report, we would like to highlight the importance of being aware of this condition to provide the patients with the appropriate treatment.
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Terai, Haruhiko, and Masashi Shimahara. "Chronic oral ulcer associated withCandida." Mycoses 53, no. 2 (March 2010): 168–72. http://dx.doi.org/10.1111/j.1439-0507.2008.01675.x.
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Chung, Hae‐Shin, Nam Soo Kim, Young Bae Kim, and Won Hyoung Kang. "Eosinophilic ulcer of oral mucosa." International Journal of Dermatology 37, no. 6 (June 1998): 432. http://dx.doi.org/10.1046/j.1365-4362.1998.00423.x.
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Oren, Ran, and Alexander Fich. "Oral contraceptive-induced esophageal ulcer." Digestive Diseases and Sciences 36, no. 10 (October 1991): 1489–90. http://dx.doi.org/10.1007/bf01296821.
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Guo, Lan, Zhi Yu Zhao, Jing Bai, and Shu Ying Han. "Preparation and Treatment for Oral Ulcer of Quercetin and the Drug-Loaded Chitosan Composite Material." Advanced Materials Research 583 (October 2012): 44–48. http://dx.doi.org/10.4028/www.scientific.net/amr.583.44.
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With the drug-loaded chitosan as film forming materials, use salivation method to prepare Quercetin-chitosan composite film of oral ulcer and use this film to the treatment for the rat model of oral ulcer. To study the therapeutic effect for oral ulcer of the Quercetin-Chitosan composite film by measuring the area, the volume and the healing speed of the ulcer, observing edema and congestion degree of ulcer surface, and detecting the pathological changes of ulcer tissue by HE staining.
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Rafika, Mega, and Rian Setiadhi. "LESI ORAL TERKAIT LEUKEMIA MIELOID KRONIK: LAPORAN KASUS." ODONTO : Dental Journal 6 (July 11, 2019): 62. http://dx.doi.org/10.30659/odj.6.0.62-67.
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Background: Oral lesion is one the clinical signs found in chronic myeloid leukemia (CML). CML is a myeloid cell neoplasm that have oral manifestations such as gingival hyperplasia, spontaneous haemorrhage, petechiae, oral infection, mucosal pallor, and ulceration. The purpose is to find out how to diagnose and oral lesions associated CML to occure, so the dentist could provide the right therapyCase Management: 46 years old male was referred from Internal Medicine Department with diagnosis CML. The patient complained of pain at the right upper gum. Cheilitis exfoliative was found at the extra oral examination, while intra oral examination found ulcer at the palate. Blood test result showed decreases of Haemoglobin, Hematocrite, erythrocytes which showed iron deficiency anemia causes disruption of oral mucosal integrity, thereby facilitating oral ulcerations. Based on history, clinical examination and laboratory investigation, intra-oral abnormality was diagnosed as oral lesion associated CML. Triamcinolone acetonide 0.1% in orabase as theraphy oral lesion, vaseline album for management exfoliative cheilitis, and Surbex Z® as multivitamin. Oral ulcer improved within 6 weeks.Conclusion: The diagnosis oral lesions associated CML can be diagnosed based on history, clinical examination and laboratory investigation. Oral ulcers in this patient caused by iron deficiency anemia.
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Bhaskaran, Abhilash, Sam Harding, and David Courtney. "An Unusual Presentation of Metastatic Colon Adenocarcinoma in the Oral Cavity." Case Reports in Dentistry 2011 (2011): 1–2. http://dx.doi.org/10.1155/2011/357518.
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Background. A case report of a nonhealing ulcer of the tongue histologically proven to be adenocarcinoma.Method. A 92-year-old man underwent clinical, immunochemistry, and imaging investigation.Results. Tests confirmed a distant metastasis of a primary colorectal carcinoma.Conclusion. Metastasis from colorectal carcinoma to the oral cavity is primarily to bone, but non-healing ulcers of the oral cavity should be considered in differential diagnoses.
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Sisay, Woretaw, Yared Andargie, Mulugeta Molla, and Alefe Norahun. "Hydromethanolic Crude Extract of the Leaf of Urtica simensis Hochst. ex. A. Rich. (Urticaceae) Acquires Appreciable Antiulcer Effect: Validation for In Vivo Antiulcer Activity." Evidence-Based Complementary and Alternative Medicine 2021 (July 20, 2021): 1–12. http://dx.doi.org/10.1155/2021/6591070.
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Background. Urtica simensis has been used for the treatment of peptic ulcer disease in Ethiopian folkloric medicine by drinking its juice after boiling the semicrushed leaf. To our latest understanding, no in vivo study was available regarding its antiulcer activity. The present study was done to appraise the ulcer-protective and ulcer healing activity of hydromethanolic crude extract of leaf of U. simensis in rats. Methods. Preliminary qualitative phytochemical screening and oral acute toxicity were carried out using a standard protocol. To validate U. simensis in vivo antiulcer potential pyloric ligature, cold restraint stress and acetic acid-induced ulcer models were employed. The extracts (100, 200, and 400 mg per kg of body weight per day), standard treatment (omeprazole 20 mg/kg/day), and vehicle (distilled water 10 ml/kg/day) were given to treatment, positive, and negative controls by oral gavage, respectively. Parameters were then evaluated accordingly after the humane scarification of rats. Results. Any sign of toxicity was not observed in the oral acute toxicity test. The crude extracts exerted a significant ( P < 0.05 ) inhibition of ulcer risk compared to the negative control. In the pylorus ligation-induced ulcer model, its antisecretory activity was in a dose-dependent manner. The highest gastroprotective effect (67.68%) was exhibited by the 400 mg/kg/day dose of 80% methanolic crude extract. Regarding the chronic ulcer model, treatment at a dosage of 100, 200, and 400 mg/kg/day cures ulcers by 33.54%, 58.33%, and 67.07%, respectively, as compared to the negative control groups remarkably. Conclusion. The findings of the present study confirmed the safety and a promising in vivo ulcer healing and antiulcerogenic activity of U. simensis, thus supporting the traditional claim. In-depth investigations on the plant, however, are highly recommended.
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Khozeimeh, Faezeh, Zahra Saberi, Atefeh Tavangar, and Fahime Fakhari Badi. "Effect of Herbal Echinacea on Recurrent Minor Oral Aphthous Ulcer." Open Dentistry Journal 12, no. 1 (August 31, 2018): 567–71. http://dx.doi.org/10.2174/1874210601812010567.
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Background: The oral aphthous is a common oral ulcer with intense pain and there is no treatment for it, yet. Echinacea is an herbal medicine that moderated the immune system. Objective: The aim of this study was to investigate the effects of Echinacea on the treatment of aphthous ulcer. Methods: 50 patients with minor aphthous participated in our study. 25 patients take 3 tablets in a day for five weeks (case group) and 25 patients didn’t take any tablets (control group). The patients were monitored for one month before taking the tablets for six months. During this period, the number of lesions, complete improvement of ulcers, recurrence rate and intensity of pain were considered in each month. Finally, the Friedman and ANOVA tests used to analyze the obtained data. Result: Our study showed a significant difference between a number of lesions during six-month in case and control groups (p>0.001). In this way, we observed that the number of lesions was decreased significantly after six months in the case group. Hence, ANOVA analysis showed a significant decrease between each month for the intensity of pain (p=0.025), complete improvement (p<0.001) and recurrence rate (p=0.026). Conclusion: In conclusion, we showed that Echinacea tablets as an herbal medicine have positive effects on a number of lesions, intensity of pain, complete improvement and recurrence rate in patients with recurrent minor aphthous ulcers.
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Sumbul, Sabiha, Mohd Aftab Ahmad, Mohd Asif, Ibne Saud, and Mohd Akhtar. "Evaluation of Myrtus communis Linn. berries (common myrtle) in experimental ulcer models in rats." Human & Experimental Toxicology 29, no. 11 (March 2, 2010): 935–44. http://dx.doi.org/10.1177/0960327110364154.
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The present study was conducted to investigate the protective effect of the dried berries of Myrtus communis L. in gastric ulcer against ethanol, indomethacin and pyloric ligation induced models in Wistar rats. Two doses of aqueous extracts of M. communis (AE 1 and AE2) at the dose 105 and 175 mg/kg, respectively, and methanolic extracts (ME1 and ME2) at the dose of 93 and 154 mg/kg, respectively, were administered orally to animals prior to the exposure of ulcerogens. The parameters taken to assess anti-ulcer activity were ulcer index, gastric juice volume, gastric pH, total acidity, gastric wall mucus and histopathological studies. Oral administration of AE1 and AE2 significantly reduced the ulcer index in all models of ulcers. Low dose of aqueous extract and high dose of methanolic extract of M. communis exhibited more significant effect in comparison to omeprazole (standard drug) in ethanol-induced ulcer model. Both the doses of aqueous and methanolic extracts also reduced the gastric juice volume, total acidity and increased the gastric pH and gastric wall mucus content in all the models of ulcers used in the present study. Histopathological examinations of gastric tissues of rats treated with the aqueous and methanolic extracts in indomethacin-induced ulcer exhibited significant ulcer-protective effect at both the dose levels.
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Huang, Samuel, Isabelle Delacroix, and Diane Labrousse. "A rare case of cytomegalovirus induced oral ulcer in an immunocompromised patient." Journal of Oral Medicine and Oral Surgery 25, no. 3 (2019): 22. http://dx.doi.org/10.1051/mbcb/2019006.
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Introduction: Oral manifestations of cytomegalovirus are rare. Observation: We report the case of an atypical and persistent oral location of cytomegalovirus, in the form of ulcers, in a patient suffering from granulomatosis with polyangiitis and treated by rituximab. Discussion: In front of a chronic ulcer, a differential diagnosis must be made to exclude different etiologies, by order of severity, frequency or according to the clinical situation of the patient. The main differential diagnosis that must be excluded is a squamous-cell carcinoma. Conclusion: Cytomegalovirus ulcers are not specific and its etiology cannot be affirmed clinically. A pathological examination is essential to allow the quick establishing of a treatment in an immuno-compromised patient to prevent further complications.
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Surboyo, Meircurius Dwi Condro, Fatma Yasmin Mahdani, Diah Savitri Ernawati, Andari Sarasati, and Fianza Rezkita. "The Macrophage Responses during Diabetic Oral Ulcer Healing by Liquid Coconut Shell Smoke: An Immunohistochemical Analysis." European Journal of Dentistry 14, no. 03 (May 24, 2020): 410–14. http://dx.doi.org/10.1055/s-0040-1712776.
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Abstract Objectives Liquid coconut shell smoke (LC-SS) is used in natural food preservation for a long history. The purpose of this study was to analyze the role of LC-SS in macrophage responses during diabetic oral ulcer healing as medication. Materials and Methods Oral ulcers were induced in the labial lower mucosa of the research subjects using a round steel blade following diabetic induction by means of alloxan. Twenty-four diabetic Wistar rats presenting oral ulcers were divided into two groups, a test group, which was given topical treatment of LC-SS and a control group, which was given benzydamine hydrochloride (BHCl). The role of LC-SS in macrophages was assessed by means of immunohistochemistry for nuclear factor kappa B (NF-κB) and tumor necrosis factor-α (TNF-α) expression. Result LC-SS increased macrophages compared with BHCl (p = 0.000). The LC-SS affected only TNF-α expression by stimulating NF-κB expression (p = 0.046) but did not macrophage numbers (p = 0.861). Conclusion LC-SS has a stronger effect compared with BHCl on diabetic oral ulcer healing by increasing macrophage response to produce TNF-α while decreasing NF-κB expression.
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Inchab, Kannika, Parirat Khonsung, Natthakarn Chiranthanut, Puongtip Kunanusorn, Saranyapin Potikanond, Sunee Chansakaow, Ampai Panthong, and Seewaboon Sireeratawong. "Anti-Gastric Ulcer Activity of the Water Extract from Payawanorn (Pseuderanthemum Palatiferum)." Journal of Health Science and Medical Research 36, no. 2 (May 24, 2018): 89. http://dx.doi.org/10.31584/jhsmr.2018.36.2.1.
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Objective: To examine the anti-gastric ulcer activity of Payawanorn (Psuderanthemum palatiferum) water extract (PPE) in rats.Material and Methods: Evaluation of anti-gastric ulcer activity of PPE was performed using three induced gastric ulcers models: (1) ethanol/hydrochloric acid (EtOH/HCl), (2) restraint water immersion stress and (3) indomethacin. Ulcer indices were determined by microscopic examination (10X). Pylorus ligation and gastric-wall mucus determination were used to investigate the mechanism of anti-gastric ulcer activity of PPE.Results: Oral administration of PPE (150, 300 and 600 mg/kg) significantly inhibited gastric ulcer formation induced by EtOH/HCl, by water immersion restraint stress, and by indomethacin in rats (p-value<0.05). PPE at 600 mg/kg showed a high percent inhibition of gastric ulcer formation in all models. In the pylorus-ligated model, pretreatment with PPE had no effect on pH, acidity output or the gastric acid secretion rate, demonstrating that PPE lacks an anti-secretory effect. Gastric wall mucus was markedly preserved by pretreatment PPE at 600 mg/kg (18.91±2.57 μg alcian blue/g wet stomach) after ethanol-induced ulcer when compared to that the control group (12.38±1.02 μg alcian blue/ g wet stomach).Conclusion: PPE possesses an anti-gastric ulcer effect related to the preservation of gastric mucus, supporting the traditional use of P. palatiferum to treat gastric ulcers.
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Inchab, Kannika, Parirat Khonsung, Natthakarn Chiranthanut, Puongtip Kunanusorn, Saranyapin Potikanond, Sunee Chansakaow, Ampai Panthong, and Seewaboon Sireeratawong. "Anti-Gastric Ulcer Activity of the Water Extract from Payawanorn (Pseuderanthemum Palatiferum)." Journal of Health Science and Medical Research 36, no. 2 (May 24, 2018): 89. http://dx.doi.org/10.31584/jhsmr.v36i2.1.
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Objective: To examine the anti-gastric ulcer activity of Payawanorn (Psuderanthemum palatiferum) water extract (PPE) in rats.Material and Methods: Evaluation of anti-gastric ulcer activity of PPE was performed using three induced gastric ulcers models: (1) ethanol/hydrochloric acid (EtOH/HCl), (2) restraint water immersion stress and (3) indomethacin. Ulcer indices were determined by microscopic examination (10X). Pylorus ligation and gastric-wall mucus determination were used to investigate the mechanism of anti-gastric ulcer activity of PPE.Results: Oral administration of PPE (150, 300 and 600 mg/kg) significantly inhibited gastric ulcer formation induced by EtOH/HCl, by water immersion restraint stress, and by indomethacin in rats (p-value<0.05). PPE at 600 mg/kg showed a high percent inhibition of gastric ulcer formation in all models. In the pylorus-ligated model, pretreatment with PPE had no effect on pH, acidity output or the gastric acid secretion rate, demonstrating that PPE lacks an anti-secretory effect. Gastric wall mucus was markedly preserved by pretreatment PPE at 600 mg/kg (18.91±2.57 μg alcian blue/g wet stomach) after ethanol-induced ulcer when compared to that the control group (12.38±1.02 μg alcian blue/ g wet stomach).Conclusion: PPE possesses an anti-gastric ulcer effect related to the preservation of gastric mucus, supporting the traditional use of P. palatiferum to treat gastric ulcers.
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Obata, Soichiro, Koji Kobayashi, Misaki Toda, Etsuko Miyagi, and Shigeru Aoki. "Genital Ulcer of Behçet Disease Localized in the Vagina May Lack Pain, Making It Difficult to Assess." Case Reports in Rheumatology 2019 (June 10, 2019): 1–3. http://dx.doi.org/10.1155/2019/2953676.
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Genital ulcer is one of the main clinical symptoms of Behçet disease; ulcers mostly occur in the vulva and are usually quite painful. We present an unusual case of Behçet disease wherein a painless genital ulcer was localized in the vagina. Our case is of a 43-year-old woman diagnosed with Behçet disease that was controlled with prednisolone. She became pregnant and developed fever, oral ulcers, and arthralgia at 16 weeks of gestation. Although a relapse of Behçet disease was suspected, ulceration and pain of the vulva were not observed. At 18 and 28 weeks of gestation, a vaginal ulcer was observed during regular prenatal examination, but the patient had no pain or other symptoms in the vulva. The vaginal ulcer healed at 29 weeks of gestation. No recurrence of the vaginal ulcer and other symptoms of Behçet disease were seen on subsequent follow-up examination at 1 month after delivery. Although genital ulcers of Behçet disease are common in the vulva and are generally painful, if they are located in the vagina, they can be painless. If Behçet disease is suspected based on other symptoms, a vaginal examination should be conducted as necessary for accurate evaluation of Behçet disease.
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Aggarwal, Neeraj, Sirshak Dutta, Avijit Choudhury, Mainak Dutta, Saumik Das, and Ramanuj Sinha. "Non-malignant Oral Ulcer: A Diagnostic Challenge to Otorhinolaryngologists." Bengal Journal of Otolaryngology and Head Neck Surgery 27, no. 3 (December 29, 2019): 223–28. http://dx.doi.org/10.47210/bjohns.2019.v27i3.11.
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Introduction
Apart from the malignant ulcers a wide variety of dermatological and other systemic conditions can affect oral cavity and often be a diagnostic challenge due to their similar presenting features and appearance. Despite being benign, some of them may be fatal if not diagnosed and treated timely. This study aims to assess the incidence of different non malignant ulcers in oral cavity and to estimate the need for histopathological examination for confirmation of the condition for proper management.
Materials and Methods
An institution based observational study was conducted over a time period of 16 months at a tertiary care institute. Total 172 cases were included in the present study irrespective of age, sex and duration. Malignant lesions were excluded from the study.
Results
The present study shows a slight male preponderance (M:F = 1.48:1) with majority of cases were in age group 20-40 years of age (43.02%). Most commonly encountered were recurrent aphthous stomatitis (27.9%) followed by erosive lichen planus (16.28%), oral candidiasis, angular stomatitis, traumatic ulcers and others. 78.5% were treated successfully on the basis of clinical diagnosis while 21.5% cases needed further histopathological or other investigation for confirmation of diagnosis.
Conclusion
Though the otolaryngologists are more concerned about malignant ulcer, there are many non malignant ulcers which can cause significant morbidity and can even be fatal and should be given similar importance like malignant lesions. Majority of them can be treated successfully on the basis of clinical diagnosis but histopathological examination may be required in some cases for proper diagnosis and appropriate management.
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Damaiyanti, Dian Widya, Pratiwi Soesilowati, Ira Arundina, and Rima Parwati Sari. "Effectiveness of gold sea cucumber (Stichopus hermanii) extracts in accelerating the healing process of oral traumatic ulcer in rats." Padjadjaran Journal of Dentistry 31, no. 3 (November 30, 2019): 208. http://dx.doi.org/10.24198/pjd.vol31no3.22555.
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Introduction: Gold sea cucumber (Stichopus hermanii) is a marine organism that contains omega-3 and glycosaminoglycan for enhancing collagen needed in the healing process. This study was aimed to determine the effectiveness of gold sea cucumber extracts in accelerating the healing process of oral traumatic ulcer in Wistar rats, in terms of the correlation between collagen type I expression, ulcer diameter, and body weight loss. Methods: Twenty Wistar rats (Rattus norvegicus) was divided into four groups and treated with gold sea cucumber extracts with the concentration of 80%, 40%, and 20% in the form of 0.1 ml gel daily. The negative control group received no treatment. Ulceration of the lower lip of labial mucosa was induced by a burnisher. The animals were observed for 7 days, during which they were weighed and the ulcers diameter was measured. The rats were then sacrificed after 7 days of treatment. Histometric analysis of collagen type I expression was also performed. Data obtained were analysed for differences between the group with one-way ANOVA test and the correlation was analysed with the Pearson test. Results: The significant differences (p < 0.05) between treatment groups was found in the ulcer diameters and the collagen type I expression. The most decreased ulcer diameter and the highest collagen type I expression detected in the group of treatment with a concentration of 80% — no significant differences found in the weight loss between-groups (p > 0.05). Strong correlation was also found between the expression of collagen type I and diameter of ulcer (Pearson correlation = 0.599, p = 0.05), however, no correlation found between weight loss with the expression of collagen type I (Pearson correlation = -0.102, p = 0.66), and the ulcer diameter (Pearson correlation = 0.022, p = 0.92). Conclusion: Gold sea cucumber had a potential benefit to be used as a traumatic ulcer healing medicament. Water extract of gold sea cucumber able to accelerate traumatic ulcer healing by enhancing the production of collagen type I and reduce the diameter of ulcer. There is a strong correlation between collagen type 1 expression and diameter of ulcer, and a weak correlation found between body weight loss and collagen type I expression, also with reducing ulcer diameter.Keywords: Gold sea cucumber, Stichopus hermanii, healing process, traumatic ulcer.
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Yuan, Fahu, Li Liu, Wenxuan Yu, Beibei Zhu, Siyuan Sun, Yanbing Jiang, De Chen, and Changli Zeng. "Polyphenolic extract from Artemisia selengensis Turcz ameliorates experimental oral mucositis." E3S Web of Conferences 189 (2020): 02019. http://dx.doi.org/10.1051/e3sconf/202018902019.
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Oral mucositis is a common and frequentoccurring disease and there is no effective treatment. In this study, we investigated the efficacy of polyphenolic extract from Artemisia selengensis Turcz (PPAST) in the prevention and treatment of oral mucositis. Cultured human gingival fibroblast cell HGF-1 was used as an in vitro experimental model to confirm the effect of PPAST inhibition of lipopolysaccharide(LPS) on cytotoxicity and its effect on the production of inflammatory cytokines. A rat model of oral ulcer was induced by acetic acid cauterization, and the curative effect of PPAST on oral ulcer was investigated from ulcer area and ulcer duration. PPAST significantly inhibited the toxic effect of LPS on HGF1 cells, improved the survival rate of HGF1 cells, and showed a concentration-dependent inhibition of TNF-α in HGF-1 cell. Treatment with PPAST reduced mucositis scores, promoted oral ulcer healing, and reduced plasma TNF-α levels in rats. Experimental data show that PPAST is safe and effective in the prevention and treatment of oral inflammatory diseases.
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Doyle, John L., Walter Geary, and Ernest Baden. "Eosinophilic ulcer." Journal of Oral and Maxillofacial Surgery 47, no. 4 (April 1989): 349–52. http://dx.doi.org/10.1016/0278-2391(89)90335-2.
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DA SILVA, EDUARDO LIBERATO, VINÍCIUS COELHO CARRARD, FERNANDA VISIOLI, NATÁLIA BATISTA DAROIT, TATIANA WANNMACHER LEPPER, ISADORA LUANA FLORES, and LAURA DE CAMPOS HILDEBRAND. "ORAL CHRONIC ULCER: A DIAGNOSIS CHALLENGE." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 129, no. 1 (January 2020): e86. http://dx.doi.org/10.1016/j.oooo.2019.06.355.
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Kotecha, Anish. "AKT question relating to oral ulcer." InnovAiT: Education and inspiration for general practice 11, no. 6 (June 2018): 329. http://dx.doi.org/10.1177/1755738018766826.
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