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Journal articles on the topic 'Oral ulcer'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Susanto, Hendri, Rona Tirtaardi Dewi, and Mardiah Suci Hardianti. "Oral Aphthous-like Ulcers Response to Topical Therapy in Young Adult Woman with Beta-Thalassemia Intermedia." Journal of Indonesian Oral Medicine Society 2, no. 1 (2024): 8. http://dx.doi.org/10.32793/jioms.v2i1.1157.

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Background: Beta thalassemia may have some oral manifestations. Oral mucosa ulcer may be one of the oral manifestations of beta-thalassemia. The oral ulcer may resemble recurrent aphthous stomatitis (RAS). This current case report aims to present an aphthous oral ulcer as a manifestation in young adult women with beta-thalassemia. Case report: A 28-year-old woman complained of recurrent painful oral ulcers in the labial mucosa. She was diagnosed with beta-thalassemia intermedia three years before. The ulcer may take 3-4 weeks to heal completely. Intraoral examination revealed two yellowish ulc

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2

Rutuja, Jaiswal* Tejaswini Dhawale Dr. Gajanan Sanap. "Herbs Therapies for Mouth Ulcer." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 2493–501. https://doi.org/10.5281/zenodo.14524961.

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Ulcer is a common disorder which is seen among many people. In most cases, it is an inflammatory skin rupture. There are many types of ulcers such as mouth ulcer, peptic ulcer, oesophagus ulcer, gastric ulcer. Among these mouth ulcers is common type of ulcer. Throughout the ages, treat a variety of illnesses and diseases. Mouth ulcers or aphthous ulcers are common oral lesions characterized by painful, shallow sores on the mucous membranes. This abstract explores the causes, symptoms, and potential treatments for mouth ulcers, emphasizing their impact on oral health and quality of life. Nowada

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Takeno, Mitsuhiro, Hiroaki Dobashi, Yoshiya Tanaka, et al. "Apremilast in a Japanese subgroup with Behçet’s syndrome: Results from a Phase 3, randomised, double-blind, placebo-controlled study." Modern Rheumatology 32, no. 2 (2021): 413–21. http://dx.doi.org/10.1093/mr/roab008.

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ABSTRACT Objectives Apremilast efficacy and safety was assessed in a prespecified subgroup of Japanese patients with oral ulcers associated with Behçet’s syndrome from a Phase 3 randomized, placebo-controlled, double-blind study of apremilast (RELIEF). Methods The primary end point was area under the curve for number of oral ulcers during the 12-week placebo-controlled phase (AUCWk0–12). Key secondary end points were change from baseline in oral ulcer pain, complete oral ulcer resolution, and measures of disease activity and quality of life (QoL). Results Thirty-nine Japanese patients were ran

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Ghafoor Chaudhary, Muhammad Aamir, Syed Hammad Azeem Rizvi, Afsheen Zakir, et al. "Commonest location of traumatic ulcers in edentulous patients after denture insertion." Pakistan Journal of Medical and Health Sciences 16, no. 9 (2022): 178–80. http://dx.doi.org/10.53350/pjmhs22169178.

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Aim: To evaluate frequency of commonest location of traumatic oral ulcers after complete denture insertion and find out their association with age, gender and arch type. Study design: Cross sectional observational study Place and duration: Prosthodontic department of Islamic International Dental College, Riphah International University Islamabad, from 11th Feb.,2022 till 11th April 2022. Methodology: A sample of 150 completely edentulous patients were clinically checked for traumatic ulcer development after insertion of complete denture. Frequently involved anatomical sites were noted in both

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Dewi, Amalia Eka Setya, and Atia Nurul Sidiqa. "Ulcer Traumaticus et Causa Trauma Occlusion." Interdental Jurnal Kedokteran Gigi (IJKG) 20, no. 2 (2024): 308–12. http://dx.doi.org/10.46862/interdental.v20i2.8912.

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Introduction: A Traumatic Ulcer is a type of ulcer that is caused by local factors. Traumatic ulcers usually occur on the soft tissues in the oral cavity and can be caused by many factors, one of which is occlusion trauma. Case: The clinical picture of an ulcer is that of an ulcer on the oral mucosa in an acute inflammatory state, including varying degrees of pain, redness, and swelling in various sizes and shapes. The initial lesion in traumatic ulcers is usually felt by people in the form of annoying pain. Case Management: Medication therapy such as Aloclair gel containing olyvinylpyrrolidon

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Huang, Meineng, Sheng Jiang, Tong Chen, et al. "Preparation and Evaluation of the Curative Effect of Blue Shark (Prionace glauca) Skin Collagen Composite Gel in a Rat Oral Ulcers Model." Journal of Biomaterials and Tissue Engineering 11, no. 10 (2021): 1924–31. http://dx.doi.org/10.1166/jbt.2021.2787.

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Objective: To evaluate the curative effect of blue shark skin collagen composite gel on oral mucosal ulcer using the rat oral ulcers model stimulated by glacial acetic acid. Methods: Collagen from blue shark skin was isolated and physiochemically characterized by FTIR, SDS-PAGE and scanning electron microscopy (SEM). Seventy standard male rats were divided into seven groups. The surface and the area of the ulcer were observed and calculated daily. After 12 days of administration, rats in the model group and the control group were killed and the ulcer and surrounding tissues were cut to pieces

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Vuletic, Miona, Vladimir Jakovljevic, Suzana Zivanovic, et al. "The Evaluation of Healing Properties of Galium verum-Based Oral Gel in Aphthous Stomatitis in Rats." Molecules 27, no. 15 (2022): 4680. http://dx.doi.org/10.3390/molecules27154680.

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Although oral ulcers represent one of the most frequent oral mucosal diseases, the available treatment is not sufficient to provide complete ulcer recovery without side-effects. Therefore, the aim of our study was to prepare a mucoadhesive oral gel based on Galium verum ethanol extract (GVL gel) and reveal its healing effects in the model of aphthous stomatitis in rats. Rats with oral ulcers were divided into the following groups: control (untreated), gel base (ulcer was treated with the gel base, three times per day for 10 days), and GVL gel group (the ulcer was treated with GVL gel in the sa

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Surboyo, Meircurius D. C., Diah S. Ernawati, Ira Arundina, et al. "The potential of liquid smoke as an oral ulcer remedies: A proposed mechanism based on systematic review." Journal of Pharmacy & Pharmacognosy Research 9, no. 6 (2021): 905–20. http://dx.doi.org/10.56499/jppres21.1107_9.6.905.

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Context: The standard management of oral ulcer therapy is focused only on symptomatic therapy, such as reducing pain. To date, there is no topical drug that has the pharmacodynamics to intervene in oral ulcer pathogenicity. Liquid smoke is traditionally used as a safe natural preservative. The liquid smoke is highly phenolic and compound rich. It is presumed to have analgesic and anti-inflammatory effects with potentially promising therapeutic effects on oral ulcers. Aims: To describe the possible pharmacodynamics or action mechanism of liquid smoke as a promising remedy for oral ulcer therapy

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Putra Dermawan, I. Gusti Ngurah, Ni Nyoman Gemini Sari, and Della Yudi Ardana. "THE ROLE OF JAVA CABE (Piper retrofractum vahl.) ON TRAUMATIC ULCER TREATMENT." Interdental Jurnal Kedokteran Gigi (IJKG) 18, no. 2 (2022): 74–80. http://dx.doi.org/10.46862/interdental.v18i2.5413.

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Introduction: Dental and oral diseases in Indonesia still need attention. Theoral cavity is a place for microorganisms that cause infection that can affectthe general state of health in which the oral mucosa serves as a protector ordefense to protect the oral cavity from disease. One of the most common oral mucosal diseases is traumatic ulcer. Review: Traumatic ulcer is an oraldisease that often found in the community and often underestimated.Traumatic ulcer is a pathological condition characterized by loss of epithelial tissue due to sloughing of necrotic and widespread inflammatory tissue in

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Alamoudi, N. M., E. A. ElAshiry, N. M. Farsi, D. A. El Derwi, and H. M. Atta. "Treatment of Oral Ulcers in Dogs Using Adipose Tissue-Derived Mesenchymal Stem Cells." Journal of Clinical Pediatric Dentistry 38, no. 3 (2014): 231–40. http://dx.doi.org/10.17796/1053-4628-38.3.231.

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Aim:Adipose tissue Derived Mesenchymal Stem cells (ADMSCs) represent a promising tool for new clinical concepts in supporting cellular therapy. The goal of this study was to investigate the effects of ADMSCs transplantation on oral ulcer healing in dogs.Study design:Mesenchymal stem cells were isolated from adipose tissues of dogs obtained by suction-assisted lipectomy (liposuction), by dish adherence and were expanded in culture. Oral ulcers were induced by topical application of formocresol in the oral cavity of 18 dogs. The dogs were classified into 3 groups. Either autologousADMSCs, Cortic

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Kongpuckdee, Sonsawan, Suwipa Ungphaiboon, Supreedee Sungkharak, Narubodee Phadoongsombut, and Sirima Mahattanadul. "Efficacy of An Aqueous Morinda citrifolia Fruit Extract-Phytosome Gel in Treating Oral Inflammatory Ulcer in Rabbit Model." Current Pharmaceutical Biotechnology 21, no. 15 (2020): 1699–710. http://dx.doi.org/10.2174/1389201021666200711151925.

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Background: Oral inflammatory ulcers are one of the common complaints of patients attending out-patient clinics. Previous in vivo studies had shown that an Aqueous M. citrifolia Fruit Extract (AMFE) possessed anti-inflammatory and ulcer healing activities. Therefore, a standardized topical bioadhesive gel containing AMFE-phytosome was developed and determined for its oral ulcer healing efficacy in a rabbit model. Methods: The AMFE phytosome (AMFE-P) was prepared by a complexation method with the required amount of AMFE: Phosphatidylcholine: Tween 80 to weigh ratio of 2:1:0.2. Poloxamer 407 was

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Wakiya, R., Y. Ushio, K. Ueeda, et al. "POS1362 THE EFFICACY AND CYTOKINE PROFILES DURING TREATMENT WITH APREMILAST IN PATIENTS WITH BEHÇET ‘S DISEASE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1020.1–1020. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4181.

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BackgroundApremilast has been shown to be effective in patients with Behçet’s disease (BD) in domains other than oral ulcers; however, its long-term efficacy is yet to be determined. Although serum cytokine modulation by increasing intracellular cAMP levels has been suggested as a mechanism for the efficacy of apremilast on skin areas of psoriasis [1], the relationship between efficacy and cytokine on various domains in BD has not been fully investigated.ObjectivesThis study aims to evaluate the long-term clinical efficacy of apremilast in BD and its effect on serum cytokines.MethodsIn this st

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Nodai, T., S. Hitomi, K. Ono, et al. "Endothelin-1 Elicits TRP-Mediated Pain in an Acid-Induced Oral Ulcer Model." Journal of Dental Research 97, no. 8 (2018): 901–8. http://dx.doi.org/10.1177/0022034518762381.

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Oral ulcer is the most common oral disease and leads to pain during meals and speaking, reducing the quality of life of patients. Recent evidence using animal models suggests that oral ulcers induce cyclooxygenase-dependent spontaneous pain and cyclooxygenase-independent mechanical allodynia. Endothelin-1 is upregulated in oral mucosal inflammation, although it has not been shown to induce pain in oral ulcers. In the present study, we investigated the involvement of endothelin-1 signaling with oral ulcer–induced pain using our proprietary assay system in conscious rats. Endothelin-1 was signif

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Thikekar, Ankita. "Review on Hydrogel-Based Herbal Oral Ulcer Patches." International Journal for Research in Applied Science and Engineering Technology 13, no. 7 (2025): 787–92. https://doi.org/10.22214/ijraset.2025.73081.

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Oral ulcers are a common and painful condition affecting the mucosal lining of the oral cavity. They can result from a variety of causes, including mechanical trauma, nutritional deficiencies, infections, or underlying systemic diseases. Conventional treatments, such as corticosteroids and antiseptics, often provide temporary relief but are associated with side effects and limited patient compliance. In recent years, there has been growing interest in herbal therapies due to their natural origin, safety profile, and multifunctional therapeutic actions. Herbal ingredients such as aloe vera, lic

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Vashishat, Bhart, Shruti Sinha, Tanmay Srivastava, et al. "Management of oral aphthous ulcer: A review." Bioinformation 20, no. 5 (2024): 434–38. http://dx.doi.org/10.6026/973206300200434.

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Aphthous ulcers, also known as canker sores, are a common oral condition characterized by recurrent, painful, small ulcers that typically arise on the non-keratinized mucous membranes within the mouth. Although the pathogenesis of aphthous ulcers is not completely understood; it is believed to be involved in a combination of genetic predisposition, local trauma, stress, hormonal changes, and certain environmental factors. Thus, management of aphthous ulcer revolves around reducing pain, promoting healing and preventing recurrence.

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Alamoudi, N. M., E. A. El Ashiry, N. M. Farsi, D. A. El Derwi, and H. M. Atta. "Treatment of Oral Ulcers in Dogs Using Adipose Tissue-Derived Mesenchymal Stem Cells." Journal of Clinical Pediatric Dentistry 38, no. 3 (2014): 215–22. http://dx.doi.org/10.17796/jcpd.38.3.193115427jg6vl60.

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Aim: Adipose tissue Derived Mesenchymal Stem cells (ADMSCs) represent a promising tool for new clinical concepts in supporting cellular therapy. The goal of this study was to investigate the effects of ADMSCs transplantation on oral ulcer healing in dogs. Study design: Mesenchymal stem cells were isolated from adipose tissues of dogs obtained by suction-assisted lipectomy (liposuction), by dish adherence and were expanded in culture. Oral ulcers were induced by topical application of formocresol in the oral cavity of 18 dogs. The dogs were classified into 3 groups. Either autologous ADMSCs, Co

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Hatemi, G., B. Yurttas, Z. Kutlubay, et al. "SAT0260 PENTOXYFILLINE GEL FOR ORAL ULCERS IN PATIENTS WITH BEHÇET’S SYNDROME." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1072.1–1073. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5610.

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Background:Oral ulcers, the hallmark lesion of Behçet’s syndrome (BS) can be disabling and impair eating, drinking and speaking. Despite recent advances in systemic medications for the treatment of oral ulcers, some patients do not achieve complete remission. Topical agents may help such patients by decreasing the pain and duration of oral ulcers. Pentoxyfilline (PTX) is a methylxanthine derivative that inhibits phosphodiesterase and is thought to have immunomodulatory effects in addition to improving blood flow which is its main reason for use in peripheral vascular disorders.Objectives:The a

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Lakshana S, Vijayalakshmi S, Dinakar J, and Asok Kumar K. "Effect of Tagetes erecta flower and leaf extract gel on oxidative stress and antioxidant levels in oral ulcer condition." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 2979–85. http://dx.doi.org/10.26452/ijrps.v11i3.2391.

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An oral ulcer is described by repeated or painful oral aphthae, in which oxidative stress apparently leads to its pathogenesis. The present study has been undertaken to evaluate the effects of fresh leaves and flowers of Tagetes erecta gel on oxidative stress and antioxidant levels on oral ulcer models in albino Wistar rats. The oral ulcer was induced by incision wound model and then treated with the Tagetes erecta flower and leaf extract gel for 7 days. The antioxidant activities of catalase (CAT), superoxide dismutase (SOD), the levels of glutathione (GSH) and malondialdehyde (MDA) were meas

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Safdar, Dilnasheen, and Rehana Panjawani. "Evaluation of effective strategies in the prevention of chemotherapy induced mucositis among Children." Journal of the Pediatric Infectious Diseases Society 13, Supplement_4 (2024): 23–24. http://dx.doi.org/10.1093/jpids/piae093.065.

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Abstract Background Oral mucositis is a frequent side effect of anticancer treatments. It impairs the patient’s quality of life, aggravate clinical condition, increase the risk of infection and can delay anticancer treatment. Health care workers at the NIBD and BMT Karachi, Pakistan emphasize on oral hygiene to prevent such complications for the patients. Proper oral hygiene protocol can reduce the risk of oral ulcers. In this study we have done the evaluation of oral hygiene. At NIBD and BMT among pediatric population are advice to brush their teeth twice a day, use pyodine/ Chlorhexidine 0.2

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Safa, Hasan Radhi, Hameed Ali Al-Hajjar Shatha, A.G. Al-hussainy Shymaa, and A. Al-fahham Ali. "The Etiology, Pathophysiology, and Treatment of Oral Ulcers: A Review Article." INTERNATIONAL JOURNAL OF HEALTH & MEDICAL RESEARCH 04, no. 03 (2025): 138–42. https://doi.org/10.5281/zenodo.15006053.

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Oral ulcers are painful lesions that can considerably penetrate the quality of life of a human being and arise from many etiological factors. The present review of the literature aimed to update recent findings on oral ulcer etiology, concentrating more on Oral Lichen Planus, Behçet’s disease, recurrent aphthous stomatitis, inflammatory bowel diseases, and chemotherapy as a systemic treatment. Oral ulcers are a very common clinical condition that can greatly affect a patient’s quality of life. The pathophysiology of oral ulcers has great complexity and multiple factors: many

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Minhas, Sadia, Aniqa Sajjad, Muhammad Kashif, Farooq Taj, Hamed Alwadaani, and Zohaib Khurshid. "Oral Ulcers Presentation in Systemic Diseases: An Update." Open Access Macedonian Journal of Medical Sciences 7, no. 19 (2019): 3341–47. http://dx.doi.org/10.3889/oamjms.2019.689.

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BACKGROUND: Diagnosis of oral ulceration is always challenging and has been the source of difficulty because of the remarkable overlap in their clinical presentations. AIM: The objective of this review article is to provide updated knowledge and systemic approach regarding oral ulcers diagnosis depending upon clinical picture while excluding the other causative causes. METHODS: For this, specialised databases and search engines involving Science Direct, Medline Plus, Scopus, PubMed and authentic textbooks were used to search topics related to the keywords such as oral ulcer, oral i

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Prathoshini, Manthra. "Management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements." Bioinformation 16, no. 12 (2020): 992–98. http://dx.doi.org/10.6026/97320630016992.

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Recurrent Aphthous ulcers are the most common oral lesions among dental patients. The ulcers, which usually occur on the nonkeratinized oral mucosa, can cause considerable pain and may interfere with eating, speaking, and swallowing. Therefore, it is of interest to report data on the management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements. Case sheets of 76 patients who underwent treatment for recurrent aphthous ulcer between June 2019 and March 2020 at the Saveetha Dental College, India were used in this analysis. Data was analyzed using Chi

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Prathoshini, Manthra. "Management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements." Bioinformation 16, no. 12 (2020): 992–98. http://dx.doi.org/10.6026/97320630016992.

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Recurrent Aphthous ulcers are the most common oral lesions among dental patients. The ulcers, which usually occur on the nonkeratinized oral mucosa, can cause considerable pain and may interfere with eating, speaking, and swallowing. Therefore, it is of interest to report data on the management of recurrent aphthous ulcer using corticosteroids, local anesthetics and nutritional supplements. Case sheets of 76 patients who underwent treatment for recurrent aphthous ulcer between June 2019 and March 2020 at the Saveetha Dental College, India were used in this analysis. Data was analyzed using Chi

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Nzhad Mustafa, Bero, and Ali Fakhree Alzubaidee. "Comparative Evaluation of The Efficacy of Topical Hyaluronic Acid ( 0.2%) and Topical Triamcinolone Acetonide( 0.1%) in The Treatment of Recurrent Aphthous Stomatitis." Diyala Journal of Medicine 19, no. 2 (2020): 107–17. http://dx.doi.org/10.26505/djm.19025470628.

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Background: Recurrent aphthous ulcers are the most common oral lesion. They are classified into minor, major, and herpetiform ulcers. More than 85% of recurrent aphthous stomatitis presents as a minor ulcer. Hyaluronic acid is a biomaterial and it is a major carbohydrate component that can be found in many tissues and recently introduced as an alternative approach to enhance wound healing. Triamcinolone acetonide is a synthetic corticosteroid and it has two forms for topical use cream (0.1%) and ointment (0.1%). Objective: To make a comparison between the effectiveness of hyaluronic acid (0.2%

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Arwidasari, Annisya Ristie, Twi Agnita Cevanti, and Isidora Karsini Soewondo. "Effectiveness of Sargassum sp. ethanolic extract on traumatic ulcers healing in the labial mucosa of Wistar strain (Rattus norvegicus)." Padjadjaran Journal of Dentistry 31, no. 1 (2019): 73. http://dx.doi.org/10.24198/pjd.vol31no1.16513.

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Introduction: Oral ulcer lesions are one of the most common lesions in the oral cavity. The prevalence of traumatic ulcers is quite high compared to other oral lesions. Brown algae, Sargassum sp. is one of the algae contains flavonoids, vitamin A, vitamin C, iron, and calcium, which play a role in wound healing and has economic value. This study was aimed to determine the effectiveness of Sargassum sp. ethanolic extract on traumatic ulcers healing in the labial mucosa of Wistar strain (Rattus norvegicus). Methods: 28 Wistar strain (Rattus norvegicus) weighed 150-200 grams. The samples were div

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Warrier, Aravind, Maguluru Sruthi, and K. Anbarasi. "Comprehensive management of major aphthous ulcer." BMJ Case Reports 14, no. 5 (2021): e241010. http://dx.doi.org/10.1136/bcr-2020-241010.

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Recurrent aphthous ulcers are the most prevalent oral mucosal disease, but the subset major aphthous ulcer is a less frequent type. These ulcers are refractory, may persist for several weeks to months, and interfere with the normal state of health. The aetiology is multifactorial and so is the treatment. We present a case of an adolescent male patient reported with multiple oral ulcers. He developed three ulcers simultaneously and suffered for 10 months despite using topical medications prescribed by different dental practitioners. We executed a multidisciplinary treatment approach that result

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Thompson, Lester D. R. "Oral traumatic ulcer." Ear, Nose & Throat Journal 90, no. 11 (2011): 518–34. http://dx.doi.org/10.1177/014556131109001109.

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A Omran, Sarah, and Ban A Ghani ‎. "Immunohistochemical Localization of Epidermal Growth Factor Receptor in Rat Buccal Mucosa Treated with Fenugreek Leaf Oil." Iraqi Journal of Veterinary Medicine 48, no. 2 (2024): 72–80. https://doi.org/10.30539/9hb0jd31.

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The lack of effective treatment for oral mucosal ulcers has motivated clinicians to search for other therapeutic techniques to improve oral ulcer healing. Applying fenugreek to an ulcer triggers the release of its anti-inflammatory components, that might reduce any superfluous inflammatory processes and accelerate wound healing. The aim of this study was to investigate the effect of fenugreek leaf oil on the ulcer associated with the expression of epidermal growth factor receptor (EGFR). A total of 24 adult male rats weighing between 350 and 450 grams and 4-6 months of age were used in this st

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Irmawati, Anis, Alfin Rahmad Cahyadi, Sherina Fatwa Imanu, et al. "Healing Process on the Oral Traumatic Ulcer (OTU): A Review." International Journal of Advanced Multidisciplinary Research and Studies 5, no. 3 (2025): 1147–56. https://doi.org/10.62225/2583049x.2025.5.3.4428.

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Background Oral and dental health is a very important part for humans. Basic Health Research in 2018 showed that the prevalence of dental and oral problems in Indonesia still reached 45.3%. In Indonesia, the incidence of oral traumatic ulcers is 93.3% when compared to other oral lesions. Oral traumatic ulcers are often painful and appear as erythematous, raised edges with yellowish-white necrotic pseudomembranes that can be easily removed, and can occur on the buccal mucosa, tongue, and lower lip. Purpose This paper aims to explain the healing process of oral traumatic ulcers. Discussion Oral

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MR, Miah, Afsana L, Akter S, et al. "Behçet’s Disease - A Rare Form of Small Vessel Vasculitis." Journal of Medicine 24, no. 1 (2023): 56–58. http://dx.doi.org/10.3329/jom.v24i1.64905.

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Behçet’s disease is a rare vasculitis of unknown aetiology though there is a strong genetic association with HLA-B51 characteristically targets small arteries and venules. Multiple deep oral ulcer and genital ulcer is a common presentation. Ocular involvement is also commonly occurs in the form of anterior or posterior uveitis or retinal vasculitis. Neurological manifestation occurs in the form of brainstem or pyramidal tract symptom. Thrombosis can occur but renal involvement is unlikely. Our patient Mrs X, 47 year old has been suffering from recurrent episode of oral ulcer, genital ulcer, re

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Çakir, E. N., Y. Yenisoy, A. Kapusuz, et al. "AB0895-HPR A MODERATED MEDIATION ANALYSIS FOR POOR ORAL HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH BEHÇET’S DISEASE." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1471.1–1471. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3043.

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Background:Since oral ulcer is a common clinical manifestation, oral health-related quality of life (OHRQoL) is affected by the presence of oral ulcer poorly in patients with Behcet’s disease (BD).Objectives:The aim of the study was to examine associated factors for poor OHRQoL status to improve treatment outcomes in patients with BD.Methods:In this retrospective study, 339 BD patients (F/M: 179/160, mean age: 36,13±9,81 years) included. Data were collected by a structured questionnaire regarding treatment expectation, Oral Health Impact Profile-14 (OHIP-14) questionnaire for OHRQoL, oral ulce

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Aleena, Sunny Ankitha George Anjali Jayakumar S.Hemalatha T.Sivakumar. "TOBACCO INDUCED APHTHOUS ULCERATION IN A 15 YEAR OLD BOY: A CASE REPORT." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 10 (2018): 9802–5. https://doi.org/10.5281/zenodo.1456649.

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Tobacco in all forms such as cigarettes, pipes, cigars, beedis, paan etc have been involved in development of ulcers that may lead to pre-malignancies or malignancies. Tobacco is a product prepared from the leaves of the tobacco plant of the genus Nicotiana and of the Solanaceae [nightshade] family. It is one of the most abused substances in the world. The addictive chemical present in tobacco is nicotine which is equally addictive as heroin, cocaine and alcohol. As per the epidemiological data provided by Centers for Diseases Control and Prevention tobacco causes 6 million deaths per year. To

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Anggraeni, Dian, Kamaluddin Kamaluddin, and Theodorus Theodorus. "Effectiveness of Garlic Water Extract Gel (Allium sativum. L) Against Necrotic Factor Alfa Tumors and Mouth Ulcer Diameter in Wistar White Male Rats." Biomedical Journal of Indonesia 6, no. 1 (2020): 27–34. http://dx.doi.org/10.32539/bji.v6i1.7970.

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Oral ulcers are pathological conditions that are characterized by loss of epithelial tissue, causing inflammation. During inflammation, the inflammatory mediator is TNF will increase. Therefore, drugs are needed to suppress TNF-levels to suppress inflammation. One of the herbal ingredients that can suppress inflammation is garlic. In vivo laboratory experimental research with pre-post systems. The samples used were 36 male Wistar white rats divided into 6 groups (6 individuals / groups), namely the group without drug treatment (as pre-treatment data), negative control group namely HPMC gel bas

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Tyagi, C. K., Satendra Kumar Saha, and Sunil Kumar Shah. "Evaluation of anti-ulcer activity of the leaf extract of Solanum pubescens willd. (Solanaceae) in Wistar albino Rats." Journal of Drug Delivery and Therapeutics 13, no. 9 (2023): 98–106. http://dx.doi.org/10.22270/jddt.v13i9.6203.

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The present study showed that the methonolic extract of Solanum pubescens willd leaves possess Anti- ulcer in animal model. The anti-ulcer activity was evaluated against Pylorus ligated ulcers. Gastric ulcer disease is an imbalance between mucosal defense factors (bicarbonate, mucin, prostaglandin, nitric oxide, and other peptides and growth factors) and injurious factors (acid and pepsin). Oral administration of methanol extract of solanum pubescens willd at doses of 200 and 400mg/kg exhibited dose dependent inhibition percentage of 36.28% and 52.3% (p<0.001) respectively compared to the u

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Kim, Hyun Sil. "Ulcerative Conditions of Oral Mucosa." Journal of The Korean Dental Association 50, no. 12 (2012): 727–31. http://dx.doi.org/10.22974/jkda.2012.50.12.002.

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An ulcer is defined as loss of epithelium. Although many oral ulcers have similar clinical appearances, their etiologies encompass many disorders, including trauma, infection, immunologic disease, and malignant oral cancer. Oral squamous cell carcinoma(SCC) occupying about 90% of oral cancer, usually manifests as unhealed ulcer over 2 weeks. Oral SCC can metastasize to the cervical neck lymph node, and therefore the surgical therapeutic modality for oral SCC could encompass the neck node dissection as well as wide excision for primary lesions, which should leave the post-operative complication

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Agung, Ida Ayu Draupadi Darmadewi, Susy Purnawati, and I. Made Krisna Dinata. "Fingerroot (Boesenbergia pandurate roxb.) Extract Gel Increasing Fgf-2 Expression and Accelerating The Healing Process in Oral Mucosal Ulcers of Wistar Rats." Interdental Jurnal Kedokteran Gigi (IJKG) 21, no. 1 (2025): 20–26. https://doi.org/10.46862/interdental.v21i1.9516.

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Introduction: The human oral cavity plays an important role in daily activities such as eating and speaking. The occurrence of oral problems such as oral ulcers known as canker sores will make it difficult to speak, chew food and discomfort when swallowing which will be felt in the inflammatory phase. The purpose of this study was to prove that the administration of fingerroot extract gel (Boesenbergia pandurata Roxb.) 10% can increase FGF-2 expression and can reduce the diameter of ulcers in the healing process of oral mucosal ulcers of Wistar rats. Material and Methods: Fingerroot extract ge

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Rashid, Sulthan Al, Syed Ziaur Rahman, and Saif Khan. "Comparative study for safety and efficacy of a novel folic acid formulation gel with 0.1% triamcinolone acetonide paste in experimentally induced oral ulcer." Indian Journal of Physiology and Pharmacology 65 (June 2, 2021): 39–44. http://dx.doi.org/10.25259/ijpp_11_2021.

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Objectives: The objective of the present study was to evaluate the efficacy and safety of 0.1% novel folic acid gel in blunt dental instrument-induced oral ulcer in animal models (both rats and rabbits). Materials and Methods: The study was conducted in the Experimental Laboratory, Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University. Animals were randomly divided into three interventional groups, namely Group 1 (folic acid gel), Group 2 (triamcinolone oromucosal paste) and Group 3 (control). We created a linear oral ulcer of 5 mm with the blunt dental instru

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Wu, Weiliang, Jianyong Ruan, Daxu Li, et al. "Effect of dexamethasone on levels of inflammatory factors and EGF mRNA in rabbits suffering from oral ulcers." Tropical Journal of Pharmaceutical Research 20, no. 2 (2022): 351–57. http://dx.doi.org/10.4314/tjpr.v20i2.19.

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    Purpose: To investigate the therapeutic effect of dexamethasone on rabbits suffering from oral ulcers, and the underlying mechanism(s) of action. Methods: A rabbit model of oral ulcer was established by applying 40 % glacial acetic acid solution to the oral buccal membranes of the animals. Three groups of rabbits were used. Changes in area of the oral ulcer were recorded after dexamethasone administration. Levels of epidermal growth factor (EGF) were assayed using reverse transcription PCR (RT-PCR), while MDA levels and expression levels of IL- 6, IL-8 and TNF

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Freitas, Cristina Setim, Cristiane Hatsuko Baggio, Samanta Luiza Araújo, and Maria Consuelo Andrade Marques. "Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers." Brazilian Archives of Biology and Technology 51, no. 4 (2008): 479–83. http://dx.doi.org/10.1590/s1516-89132008000400005.

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The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral rou

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Murkute, Vishal* Dr. Datkhile S. V. "Formulation And Evaluation of Antiulcer Gel Using Extract of Spathodea Campanulata P. BEAUV." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 1077–80. https://doi.org/10.5281/zenodo.15605571.

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Spathodea Campanulata is a medicinal plant known for its potent antioxidant, anti-inflammatory, and gastroprotective properties. The present study focuses on the formulation and evaluation of an herbal antiulcer gel using extract for the treatment of oral ulcers. The bioactive compounds, including flavonoids, tannins, and alkaloids, contribute to its ulcer-healing potential by promoting tissue regeneration and reducing inflammation. The gel was formulated using a suitable polymer base, ensuring optimal viscosity, spreadability, and adherence to the oral mucosa. Various concentrations of extrac

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Stehlikova, Zuzana, Vojtech Tlaskal, Natalie Galanova, et al. "Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis." Microorganisms 7, no. 12 (2019): 636. http://dx.doi.org/10.3390/microorganisms7120636.

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Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa, and it has been recently associated with bacterial and fungal dysbiosis. To study this link further, we investigated microbial shifts during RAS manifestation at an ulcer site, in its surroundings, and at an unaffected site, compared with healed mucosa in RAS patients and healthy controls. We sampled microbes from five distinct sites in the oral cavity. The one site with the most pronounced differences in microbial alpha and beta diversity between RAS patients and healthy controls was the lower labial mucosa. De

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Sari, Rina Kartika, Diah Savitri Ernawati, and Bagus Soebadi. "RECURRENT APHTHOUS STOMATITIS RELATED TO PSYCHOLOGICAL STRESS, FOOD ALLERGY AND GERD." ODONTO : Dental Journal 6 (July 11, 2019): 45. http://dx.doi.org/10.30659/odj.6.0.45-51.

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Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress an

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Kuswandani, Faisal, Felisha Febriane Balafif, Nuroh Najmi, and Anggun Rafisa. "Understanding the Role of Sirtuins in the Pathogenesis and Treatment of Oral Ulcers: A Rapid Review." European Journal of Theoretical and Applied Sciences 3, no. 1 (2025): 210–14. https://doi.org/10.59324/ejtas.2025.3(1).20.

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Oral ulcers are a prevalent clinical condition with multifactorial etiologies, including trauma, infections, systemic diseases, and immune dysregulation. Sirtuins, particularly SIRT1, play an important role in regulating oxidative stress, inflammation, and cellular repair pathways. This rapid review, conducted using the PRISMA protocol, synthesizes current evidence on the role of sirtuins in oral ulcer pathophysiology and their potential as therapeutic targets. A comprehensive search identified 140 articles in PubMed, 41 in ScienceDirect, and 4 in the Cochrane Library, of which 1 study met the

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Faisal, Kuswandani, Febriane Balafif Felisha, Najmi Nuroh, and Rafisa Anggun. "Understanding the Role of Sirtuins in the Pathogenesis and Treatment of Oral Ulcers: A Rapid Review." European Journal of Theoretical and Applied Sciences 3, no. 1 (2025): 21 0–214. https://doi.org/10.59324/ejtas.2025.3(1).20.

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Oral ulcers are a prevalent clinical condition with multifactorial etiologies, including trauma, infections, systemic diseases, and immune dysregulation. Sirtuins, particularly SIRT1, play an important role in regulating oxidative stress, inflammation, and cellular repair pathways. This rapid review, conducted using the PRISMA protocol, synthesizes current evidence on the role of sirtuins in oral ulcer pathophysiology and their potential as therapeutic targets. A comprehensive search identified 140 articles in PubMed, 41 in ScienceDirect, and 4 in the Cochrane Library, of which 1 study met the

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Mailiza, Fitria, and Rifani Rifani. "Chronic Ulcer Mimicking Oral Squamous Cell Carcinoma (A Case Report)." B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah 6, no. 1 (2019): 49–55. http://dx.doi.org/10.33854/jbd.v6i1.211.

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Introduction: Chronic ulcers are considered as the most common ulcerations and can be differentiated with oral squamous cell carcinoma (OSCC) by the presentation of its features. OSCC define as a malignant epithelial neoplasm and the most common neoplasm of the oral cavity. OSCC appears as a mixed white or reddish proliferative growth-like lesion from chronic trauma. Case and management: A 50 years old female came with a painful non-healing ulcer on the lateral right side of the tongue which had been exist since 6 months prior. There had been a gradual increase in the size of the ulcer over th

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OSSA, Yuli Fatzia, Khairiyah ULFAH, and Rizki Rachmayani SITINJAK. "Treatment of traumatic ulcer induced by fixed orthodontic appliance: a case report." Journal of Syiah Kuala Dentistry Society 7, no. 1 (2022): 69–72. http://dx.doi.org/10.24815/jds.v7i1.27259.

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Orthodontic treatment aims to improve the oral health of the patient. Still, orthodontic treatment canalso cause problems in the oral cavity, such as the appearance of traumatic ulcers caused by the use of orthodonticappliances. The following describes a chronic traumatic ulcer in a patient using fixed orthodontic appliances. CaseReport: A female patient aged 22 years complained of thrush after using braces. Clinical examination revealed asingle ulcerated lesion on the right buccal mucosa of the upper molar region adjacent to the buccal tube of theorthodontic appliance. The patient was then tr

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Nelonda, Revi, and Riani Setiadhi. "Management of chronic traumatic ulcer mimicking oral squamous cell carcinoma on the tongue." Dental Journal (Majalah Kedokteran Gigi) 51, no. 2 (2018): 76. http://dx.doi.org/10.20473/j.djmkg.v51.i2.p76-80.

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Background: Traumatic ulcers represent the most common oral mucosal lesions that can be differentiated from oral squamous cell carcinoma (OSCC) by their clinical appearance. From a clinical perspective, OSCC may resemble a chronic traumatic ulcer (CTU) because the base of the CTU that is healing is filled with reddish-pink granulated tissue, similar to that in OSCC. Purpose: The aim of this case report is to provide information about the oral management of a CTU case that imitates OSCC. Case: A 30-year old female presented with a major, painful, non-healing ulcer located on the right lateral o

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Gondkar, Sanika Sanjay. "Therapeutic Potential of Jasmine Herbal Lozenges in the Treatment of Recurrent Aphthous Stomatitis." International Journal for Research in Applied Science and Engineering Technology 13, no. 5 (2025): 5170–79. https://doi.org/10.22214/ijraset.2025.71397.

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Mouth ulcers, also known as aphthous ulcers, are common inflammatory lesions that affect the mucous membranes of the oral cavity. They can cause significant discomfort, pain, and difficulty in eating, drinking, and speaking. Conventional treatments, such as topical corticosteroids and antiseptic gels, often provide temporary relief and may have undesirable side effects. In response to the growing demand for safe and effective natural remedies, this study focuses on the formulation and evaluation of herbal lozenges containing Jasminum sambac (jasmine) extract for the treatment of mouth ulcers.

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Khalid, Basil, Aeeza Malik, Sharina Naz, Marium Aftab, Sidra Akram, and Malik Saleem Shaukat. "Efficacy of Coconut Milk on Healing of Oral Ulcers in Experimental Model; A Comparative Study." Journal of the Pakistan Dental Association 29, no. 04 (2020): 211–16. http://dx.doi.org/10.25301/jpda.294.211.

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OBJECTIVE: This study was carried out to observe the morphological changes in healing of oral mucosal ulcers in experimental animals by applying coconut milk. METHODOLOGY: This experimental study was spanned over one month. It was carried out at animal experimental lab of University of Health Sciences Lahore, Pakistan. A total of 30 rabbits were divided into 2 groups (Group A & B, control & experimental respectively). Oral ulcers were induced in all the rabbits by using 4mm diameter punch biopsy apparatus through standard protocol. Normal healing in Control group was compared with the

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Revianti, Syamsulina, Puguh Bayu Prabowo, Lita Agustia, and Isidora Karsini. "Innovative Treatment Using Salmon Skin Extract as Topical Application for Traumatic Oral Ulcer Healing: Animal Models." Archives of Orofacial Sciences 16, Supp. 1 (2021): 37–42. http://dx.doi.org/10.21315/aos2021.16.s1.7.

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Salmon skin extract contains high proline and hydroxyproline, and has been suggested as a potential topical agent for traumatic oral ulcer healing. The aim of this study was to evaluate the effect of salmon skin extract as traumatic oral ulcer healing. A total of 32 Wistar rats (200 g to 250 g) were distributed into four groups. Group 1 served as the control group (no treatment), Group 2 was topically treated with salmon skin extract agent 4%, Group 3 was topically treated with salmon skin extract agent 5%, and Group 4 was topically treated with salmon skin extract agent 6%. Traumatic ulcers a

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