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Relevant bibliographies by topics / Orally disintegrating tablet

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Academic literature on the topic 'Orally disintegrating tablet'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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Journal articles on the topic "Orally disintegrating tablet"

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Chue, Pierre, Barry Jones, Cindy C. Taylor, and Ruth Dickson. "Dissolution Profile, Tolerability, and Acceptability of the Orally Disintegrating Olanzapine Tablet in Patients with Schizophrenia." Canadian Journal of Psychiatry 47, no. 8 (2002): 771–74. http://dx.doi.org/10.1177/070674370204700809.

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Objectives: This pilot study investigates the dissolution profile, tolerability, and acceptability of an orally disintegrating olanzapine tablet in patients with schizophrenia. Method: Eleven patients with schizophrenia stabilized on oral olanzapine (mean dosage 12.7 mg daily [SD5.2]) were given an orally disintegrating olanzapine tablet, rather than their usual tablet, daily for 7 days. At each visit, visual assessments were made for elapsed time to initial disintegration (every 15 seconds) and complete disintegration (every 1 minute). At the end of the study, patients completed a drug-accept

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Draksiene, Gailute, Brigita Venclovaite, Lauryna Pudziuvelyte, Liudas Ivanauskas, Mindaugas Marksa, and Jurga Bernatoniene. "Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation." Pharmaceutics 13, no. 6 (2021): 879. http://dx.doi.org/10.3390/pharmaceutics13060879.

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The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical and disintegration properties and good dissolution rate when prepared in tablet press using 10.8 kN and 11.0 kN compression force. Chitosan is a suitable biopolymer to moderate the disintegration process in orally disintegrating tablets.

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Eremin, V. A., E. V. Blynskaya, and V. V. Bueva. "Orally disintegrating tablets: mechanisms, preparation methods, problems and achievements." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 6 (December 19, 2023): 25–32. http://dx.doi.org/10.33920/med-13-2306-03.

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The oral route of drug administration is considered one of the preferred delivery methods. In recent years, orally disintegrating tablets (ODTs) have become convenient pharmaceutical dosage forms, especially for specific patient populations such as pediatric, geriatric, and psychiatric patients with dysphagia. Rapid disintegration and increased bioavailability are some of the essential characteristics of ODTs that make them superior to other traditional pharmaceutical dosage forms. Orally disintegrating tablets are pills that disintegrate within a few seconds after being placed in the oral cav

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Shashank Khailkhura, Bhavana Singh, Deepika Joshi, and Nidhi Semwal. "Orally disintegrating tablet: A review." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 018–25. http://dx.doi.org/10.30574/wjbphs.2022.11.3.0124.

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Orally dispersive tablets are solid dosage forms that dissolve in the mouth in within 10 to 30 seconds, enabling waterless ingestion. The tablet dissolves quickly due to its fast breakdown, which also causes the effects to start acting quickly. ODTs can help patients with a variety of conditions, including pediatrics, geriatrics, psychosis, dysphagia, bedridden discomfort, comatose patients, young patients with undeveloped muscular and nervous systems, patients with hand tremors, and patients who travel often. It provides high stability, precise dosage, efficient manufacture, and smaller packi

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Shashank, Khailkhura, Singh Bhavana, Joshi Deepika, and Semwal Nidhi. "Orally disintegrating tablet: A review." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 018–25. https://doi.org/10.5281/zenodo.7180875.

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Orally dispersive tablets are solid dosage forms that dissolve in the mouth in within 10 to 30 seconds, enabling waterless ingestion. The tablet dissolves quickly due to its fast breakdown, which also causes the effects to start acting quickly. ODTs can help patients with a variety of conditions, including pediatrics, geriatrics, psychosis, dysphagia, bedridden discomfort, comatose patients, young patients with undeveloped muscular and nervous systems, patients with hand tremors, and patients who travel often. It provides high stability, precise dosage, efficient manufacture, and smaller packi

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Nestorovska-Gjosevska, Biljana Nestorovska-Gjosevska, Marija Glavas-Dodov, and Katerina Goracinova. "Orally disintegrating tablet: formulation design and optimisation using Response Surface Methodology." Macedonian Pharmaceutical Bulletin 51 (2005): 15–22. http://dx.doi.org/10.33320/maced.pharm.bull.2005.51.003.

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The objective of this study was to develop diazepam orally disintegrating tablets and to optimize tablets characteristics using response surface methodology (RSM). Tablets were prepared by direct compression of mixture containing mannitol, copovidone, crosspovidone flavor and lubricant. A full factorial design for 2 factors at 3 levels each was applied to investigate the influence of 2 formulation variables on the mechanical strength/hardness, the percent of friability, disintegration time and dissolution of the poorly soluble active ingredient. The amounts of copovidone and crosspovidone were

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Alami-Milani, Mitra, Sara Salatin, Elaheh Nasiri, and Mitra Jelvehgari. "Preparation and optimization of fast disintegrating tablets of isosorbide dinitrate using lyophilization method for oral drug delivery." Therapeutic Delivery 12, no. 7 (2021): 523–38. http://dx.doi.org/10.4155/tde-2020-0127.

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Background: Orally disintegrating tablets rapidly disintegrate in saliva and then swallowed without the need for water. Materials & methods: The orally disintegrating tablets were prepared by freeze-drying of an aqueous dispersion of isosorbide dinitrate containing a matrix former (gelatin), a cryoprotectant (mannitol), a plasticizer (glycerin) and a dissolution enhancer (Tween/polyethylene glycol). Results: Results demonstrated that the selected formulation, Ft9, disintegrated within 1 min and showed faster dissolution rate compared with the commercial tablet. Conclusion: Having a fast di

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Dowson, AJ, EA MacGregor, RA Purdy, WJ Becker, J. Green, and SL Levy. "Zolmitriptan Orally Disintegrating Tablet is Effective in the Acute Treatment of Migraine." Cephalalgia 22, no. 2 (2002): 101–6. http://dx.doi.org/10.1046/j.1468-2982.2002.00319.x.

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A new formulation of zolmitriptan has been developed that dissolves on the tongue without the need for additional fluid intake. In this double-blind, parallel study, 471 patients were randomized to receive the zolmitriptan orally disintegrating tablet 2.5 mg( n=231) or matching placebo ( n=240) to treat a single moderate or severe migraine. Headache relief following zolmitriptan 2.5 mg (63%) was significantly greater than with placebo (22%) at 2 h post-dose (primary endpoint; P < 0.0001). The zolmitriptan orally disintegrating tablet was also significantly more effective than placebo for 1-

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Kumar Bhasin, Rakesh, Nirika Bhasin, and Pradip Kumar Ghosh. "Advances in Formulation of Orally Disintegrating Dosage Forms: A Review Article." Indo Global Journal of Pharmaceutical Sciences 01, no. 04 (2011): 328–53. http://dx.doi.org/10.35652/igjps.2011.33.

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Oral disintegrating tablets are solid dosage form containing medicinal substances which disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue The products are designed to disintegrate or dissolve rapidly on contact with saliva, thus eliminating the need for chewing the tablet, swallowing an intact tablet, or taking the tablet with water. ODT is general form of nomenclature for tablets that disintegrate rapidly or instantly in the oral cavity. Other alias are Quick Dissolve, Rapid Dissolve, Rapid Disintegrating, Fast Disintegrating, Fast Melt, Flash Melt and Mou

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Chono, Sumio, Katsuki Nakamura, and Megumi Matsui. "Physical properties of lansoprazole orally disintegrating tablets." Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector 13, no. 1 (2016): 5–8. http://dx.doi.org/10.1177/1741134316673226.

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Here we examined the physical properties of one branded and five generic lansoprazole orally disintegrating tablets (formulations A and B, C, D, E, and F, respectively), including their hydrophilia and tablet strength and the strength required to push the tablets out of a press through package. The wetting time of formulation F (38 ± 4 s) was approximately 1.5–2.7 fold of that of formulations A, B, C, D, and E (25 ± 2, 14 ± 1, 14 ± 1, 16 ± 1, and 22 ± 1 s, respectively). Formulations B, C, D, E, and F had hardness (>3 kgf) and friability (<1%) that could endure impact and vibration of th

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Dissertations / Theses on the topic "Orally disintegrating tablet"

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Graben, Roger Dale Parsons Daniel L. "Promethazine orally disintegrating tablet." Auburn, Ala., 2006. http://hdl.handle.net/10415/1317.

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Iyire, Affiong. "Buccal transmucosal delivery of large molecule therapeutics using orally disintegrating tablet technology." Thesis, Aston University, 2016. http://publications.aston.ac.uk/30165/.

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Buccal drug delivery combines the advantage of enhanced patient acceptance/ compliance of oral delivery, with overcoming drug degradation and poor absorption in the gastro intestinal tract (GIT), especially for large molecule therapeutics, such as insulin. Orally disintegrating tablets (ODTs) that dissolve rapidly in the mouth, are gaining widespread popularity, especially with extreme populations, including children and the elderly. This project unifies the advantages of buccal drug delivery with that of ODTs, with the view to developing a non-invasive delivery system for proteins like insuli

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Alanezi, Abdulkareem Ali. "Development of an Orally Disintegrating Mini-Tablet (ODMTs) Containing Metoclopramide HCl to Enhance Patient Compliance." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1417861431.

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Koner, Jasdip. "Formulation strategies and engineering processes for orally disintegrating tablets : the importance of robustness and disintegration." Thesis, Aston University, 2017. http://publications.aston.ac.uk/33600/.

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Orally disintegrating tablets (ODTs) are a dosage form ideal for paediatric or geriatric patients as they disintegrate/disperse within the oral cavity. Direct compression manufacture of ODTs is increasing in popularity due to its cost effectiveness and use of traditional tableting equipment, however excipients are required to fulfil certain requirements to form robust, fast disintegrating tablets. Mannitol is a vital excipient for ODT manufacture due to its high palatability, however its fragmentation behaviour under compression leads to mechanically weak and friable tablets. The work in this

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Chillas, Stephanie M. "The Formulation and Evaluation of Orally Disintegrating Tablets: Diphenhydramine HCl." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1371774622.

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Jones, Rhys. "Formulation and process engineering of freeze-dried orally disintegrating tablets." Thesis, Aston University, 2013. http://publications.aston.ac.uk/19541/.

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Orally disintegrating tablets (ODTs) which are also referred to as orodispersible and fast disintegrating tablets, are solid oral dosage forms which upon placing on the tongue, disperse/disintegrate rapidly before being swallowed as a suspension or solution. ODTs are therefore easier and more convenient to administer than conventional tablets and are particularly beneficial for paediatric and geriatric patients, who generally have difficulty swallowing their medication. The work presented in this thesis involved the formulation and process development of ODTs, prepared using freeze-drying. Gel

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Al-Husban, A. K. "Novel formulation strategies for the fabrication of lyophilised orally disintegrating tablets." Thesis, Aston University, 2011. http://publications.aston.ac.uk/13369/.

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Orally disintegrating Tablets (ODTs), also known as fast-disintegrating, fast-melt or fast-dissolving tablets, are a relatively novel dosage technology that involves the rapid disintegration or dissolution of the dosage form into a solution or suspension in the mouth without the need for water. The solution containing the active ingredients is swallowed, and the active ingredients are then absorbed through the gastrointestinal epithelium to reach the target and produce the desired effect. Formulation of ODTs was originally developed to address swallowing difficulties of conventional solid oral

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Dennison, Thomas. "Orally disintegrating tablets : formulation development, novel engineering solutions and fixed dose combinations." Thesis, Aston University, 2017. http://publications.aston.ac.uk/30817/.

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Orally disintegrating tablets (ODTs) are an attractive solid dosage form for patients who suffer from dysphagia, a difficulty in swallowing, which is particularly prevalent in paediatric and geriatric populations. ODTs and fixed dose combination (FDC) formulations are popular as they improve patient compliance and combination of the two has not previously been explored. The requirement for ODTs to disintegrate rapidly whilst also being mechanically robust means that high drug loading is a significant challenge. An ODT formulation for the betalactam antibiotic flucloxacillin was developed at do

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Al-Khattawi, Ali. "Excipient characterization and particle engineering to develop directly compressed orally disintegrating tablets." Thesis, Aston University, 2015. http://publications.aston.ac.uk/25299/.

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ODTs have emerged as a novel oral dosage form with a potential to deliver a wide range of drug candidates to paediatric and geriatric patients. Compression of excipients offers a costeffective and translatable methodology for the manufacture of ODTs. Though, technical challenges prevail such as difficulty to achieve suitable tablet mechanical strength while ensuring rapid disintegration in the mouth, poor compressibility of preferred ODT diluent Dmannitol, and limited use for modified drug-release. The work investigates excipients’ functionality in ODTs and proposes new methodologies for enhan

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Alyami, Hamad. "Paediatric patient centric development of novel processes for the formulation of orally disintegrating tablets." Thesis, Aston University, 2016. http://publications.aston.ac.uk/33120/.

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Following the European regulation for paediatric formulations, the demand for the production of paediatric dosage forms has escalated. Managing the clinical needs of children is challenging, especially as this must often be accomplished using adult medicine formulations. For this reason, further paediatric dosage forms need to be developed to address their clinical needs. There are various formulations which can be administered via the oral route including tablets, capsules, liquids and chewable tablets. It is essential to mention orally disintegrating tablets (ODTs) which have been a popular

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Book chapters on the topic "Orally disintegrating tablet"

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Jeong, Seong Hoon, Jaehwi Lee, and Jong Soo Woo. "Fast Disintegrating Tablets." In Oral Controlled Release Formulation Design and Drug Delivery. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470640487.ch10.

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Comoglu, Tansel, and Fatemeh Bahadori. "Granulation and Production Approaches of Orally Disintegrating Tablets." In Handbook of Pharmaceutical Granulation Technology, 4th ed. CRC Press, 2021. http://dx.doi.org/10.1201/9780429320057-18-21.

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"Orally Disintegrating Tablets and Related Tablet Formulations." In Pharmaceutical Dosage Forms - Tablets. CRC Press, 2016. http://dx.doi.org/10.1201/b15115-36.

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"Orally Disintegrating Tablets and Related Tablet Formulations." In Pharmaceutical Dosage Forms - Tablets. CRC Press, 2008. http://dx.doi.org/10.3109/9781420020298-13.

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Sowmyasree, Golla Venkata. "Tablets." In A Text Book of Pharmaceutics for I Year Diploma in Pharmacy. THINKPLUS PHARMA PUBLICATIONS, 2024. http://dx.doi.org/10.69613/736rs621.

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Tablets are the most widely used solid dosage form in pharmaceutical practice, offering advantages such as precise dosing, stability, and patient convenience. This section explores the various types of tablets, including immediate-release, modified-release, and orally disintegrating tablets, each designed to meet specific therapeutic needs. The composition of tablets, including active ingredients and excipients such as diluents, binders, disintegrants, and lubricants, is discussed in detail. Tablet manufacturing processes, from wet granulation and dry granulation to direct compression, are exa

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Ejeta, Fikadu. "Orally Disintegrating Tablets." In Dosage Forms - Innovation and Future Perspectives [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.109892.

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Research and development costs for a single new pharmaceutical that is introduced to the market are estimated to cost between $1 billion and $2 billion. Due to the high cost of development and the need to quickly access various technologies, it is more cost-effective (clinically and financially) to enhance current pharmaceuticals for potency, selectivity, drug metabolism, and dosing convenience before they reach the market. Orally dissolving tablets have been developed as a result. Pharmaceutical companies have created oral disintegrating tablets that dissolve or disintegrate in the mouth with

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"Orally Disintegrating Tablets." In Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition. CRC Press, 2013. http://dx.doi.org/10.1081/e-ept4-120050313.

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Noothi, Sadhana, Narender Malothu, and P. Vishnu. "Formulation and Characterization of Bilastine Oral Disintegrated Tablets Using Natural and Synthetic Super Disintegrants." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00361.

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Bilastine (BLS) is a second-generation H1- antihistamine that is approved recently for the symptomatic treatment of chronic urticaria. The present investigation was to develop oral disintegrating tablets of BLS to produce a fast onset of action. In this study, an attempt was made to compare the effect of different natural and synthetic super disintegrants on the release profile of the formulation. The formulations (BF1-BF15) of BLS oral disintegrating tablets were prepared by direct compression technique using synthetic and natural super disintegrants (Chitosan, Fenugreek mucilage, Sodium star

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MANSUR, Dr RANI, and Dr MUKESH KUMAR KUMAWAT. "ORAL DISINTEGRATING TABLET." In NOVEL DRUG DELIVERY SYSTEM. GRF BOOKS, 2022. http://dx.doi.org/10.52458/9789391842871.2022.eb.grf.asu.ch.12.

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Kumar, Amit, Londhe Sachin Bhimrao, Abha Sharma, and Awesh K. Yadav. "Polymers in orally disintegrating tablets and orally dissolving films." In Polymers for Oral Drug Delivery Technologies. Elsevier, 2025. http://dx.doi.org/10.1016/b978-0-443-13774-7.00016-5.

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Conference papers on the topic "Orally disintegrating tablet"

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Szlęk, Jakub, Adam Pacławski, Natalia Czub, and Aleksander Mendyk. "Computational Intelligence Model of Orally Disintegrating Tablets: An Attempt to Explain Disintegration Process." In International Electronic Conference on Applied Sciences. MDPI, 2021. http://dx.doi.org/10.3390/asec2021-11163.

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