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Dissertations / Theses on the topic 'Orally disintegrating tablet'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Graben, Roger Dale Parsons Daniel L. "Promethazine orally disintegrating tablet." Auburn, Ala., 2006. http://hdl.handle.net/10415/1317.

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2

Iyire, Affiong. "Buccal transmucosal delivery of large molecule therapeutics using orally disintegrating tablet technology." Thesis, Aston University, 2016. http://publications.aston.ac.uk/30165/.

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Buccal drug delivery combines the advantage of enhanced patient acceptance/ compliance of oral delivery, with overcoming drug degradation and poor absorption in the gastro intestinal tract (GIT), especially for large molecule therapeutics, such as insulin. Orally disintegrating tablets (ODTs) that dissolve rapidly in the mouth, are gaining widespread popularity, especially with extreme populations, including children and the elderly. This project unifies the advantages of buccal drug delivery with that of ODTs, with the view to developing a non-invasive delivery system for proteins like insuli

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3

Alanezi, Abdulkareem Ali. "Development of an Orally Disintegrating Mini-Tablet (ODMTs) Containing Metoclopramide HCl to Enhance Patient Compliance." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1417861431.

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4

Koner, Jasdip. "Formulation strategies and engineering processes for orally disintegrating tablets : the importance of robustness and disintegration." Thesis, Aston University, 2017. http://publications.aston.ac.uk/33600/.

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Orally disintegrating tablets (ODTs) are a dosage form ideal for paediatric or geriatric patients as they disintegrate/disperse within the oral cavity. Direct compression manufacture of ODTs is increasing in popularity due to its cost effectiveness and use of traditional tableting equipment, however excipients are required to fulfil certain requirements to form robust, fast disintegrating tablets. Mannitol is a vital excipient for ODT manufacture due to its high palatability, however its fragmentation behaviour under compression leads to mechanically weak and friable tablets. The work in this

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5

Chillas, Stephanie M. "The Formulation and Evaluation of Orally Disintegrating Tablets: Diphenhydramine HCl." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1371774622.

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6

Jones, Rhys. "Formulation and process engineering of freeze-dried orally disintegrating tablets." Thesis, Aston University, 2013. http://publications.aston.ac.uk/19541/.

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Orally disintegrating tablets (ODTs) which are also referred to as orodispersible and fast disintegrating tablets, are solid oral dosage forms which upon placing on the tongue, disperse/disintegrate rapidly before being swallowed as a suspension or solution. ODTs are therefore easier and more convenient to administer than conventional tablets and are particularly beneficial for paediatric and geriatric patients, who generally have difficulty swallowing their medication. The work presented in this thesis involved the formulation and process development of ODTs, prepared using freeze-drying. Gel

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7

Al-Husban, A. K. "Novel formulation strategies for the fabrication of lyophilised orally disintegrating tablets." Thesis, Aston University, 2011. http://publications.aston.ac.uk/13369/.

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Orally disintegrating Tablets (ODTs), also known as fast-disintegrating, fast-melt or fast-dissolving tablets, are a relatively novel dosage technology that involves the rapid disintegration or dissolution of the dosage form into a solution or suspension in the mouth without the need for water. The solution containing the active ingredients is swallowed, and the active ingredients are then absorbed through the gastrointestinal epithelium to reach the target and produce the desired effect. Formulation of ODTs was originally developed to address swallowing difficulties of conventional solid oral

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8

Dennison, Thomas. "Orally disintegrating tablets : formulation development, novel engineering solutions and fixed dose combinations." Thesis, Aston University, 2017. http://publications.aston.ac.uk/30817/.

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Orally disintegrating tablets (ODTs) are an attractive solid dosage form for patients who suffer from dysphagia, a difficulty in swallowing, which is particularly prevalent in paediatric and geriatric populations. ODTs and fixed dose combination (FDC) formulations are popular as they improve patient compliance and combination of the two has not previously been explored. The requirement for ODTs to disintegrate rapidly whilst also being mechanically robust means that high drug loading is a significant challenge. An ODT formulation for the betalactam antibiotic flucloxacillin was developed at do

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9

Al-Khattawi, Ali. "Excipient characterization and particle engineering to develop directly compressed orally disintegrating tablets." Thesis, Aston University, 2015. http://publications.aston.ac.uk/25299/.

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ODTs have emerged as a novel oral dosage form with a potential to deliver a wide range of drug candidates to paediatric and geriatric patients. Compression of excipients offers a costeffective and translatable methodology for the manufacture of ODTs. Though, technical challenges prevail such as difficulty to achieve suitable tablet mechanical strength while ensuring rapid disintegration in the mouth, poor compressibility of preferred ODT diluent Dmannitol, and limited use for modified drug-release. The work investigates excipients’ functionality in ODTs and proposes new methodologies for enhan

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10

Alyami, Hamad. "Paediatric patient centric development of novel processes for the formulation of orally disintegrating tablets." Thesis, Aston University, 2016. http://publications.aston.ac.uk/33120/.

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Following the European regulation for paediatric formulations, the demand for the production of paediatric dosage forms has escalated. Managing the clinical needs of children is challenging, especially as this must often be accomplished using adult medicine formulations. For this reason, further paediatric dosage forms need to be developed to address their clinical needs. There are various formulations which can be administered via the oral route including tablets, capsules, liquids and chewable tablets. It is essential to mention orally disintegrating tablets (ODTs) which have been a popular

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11

Bürki, Kathrin Eva [Verfasser]. "Preparation of taste masked orally disintegrating tablets by compression of coated pellets / Kathrin E. Bürki." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1111558825/34.

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12

Adhikari, Saugat. "Development and Optimization of Dextromethorphan HBr-2-Hydroxy Propyl ß-Cyclodextrin Inclusion Complex Based Orally Disintegrating Tablets Using Response Surface Methodology." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1470340367.

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13

Lo, Wei-Hsin, and 羅維新. "Study of Orally Disintegrating Tablet." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/75346992624119165909.

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碩士<br>臺北醫學大學<br>藥學系<br>92<br>The purpose of this study is to develop a orally disintegrating tablet (ODT) , which disintegrating or dissolving in oral cavity within one minute without drinking water, then swallowing the suspension or dissolved liquid. The ODT dosage form provides convenience to reduce the difficult of swallowing tablets and hard gelatin capsules for the elderly and children, increasing the compliance and therapeutic effect. First, lactose granule、lactose monohydrate、 croscarmellose Na、low-substituted hydroxypropylcellulose(L-HPC) LH-11、magnesium stearate、talc、Sodium Dodecyl

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14

Teixeira, João Filipe Dias. "A quality by design approach on pharmaceutical development of orally disintegrating tablet of Diazepam." Master's thesis, 2014. http://hdl.handle.net/10316/30201.

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Dissertação de mestrado em Tecnologias do Medicamento, apresentada à Faculdade de Farmácia da Universidade de Coimbra<br>The purpose of this study was to develop an orally disintegrating tablet (ODT) of diazepam, taken Quality by Design (QbD) approach to achieve it. Pharmaceutical development of ODT of diazepam started with the definition of the target quality attributes that it was expected for the final product. These QTPP formed the basis of the CQAs, which were identified consequently and used for all experiments. The experimental part were divided in two parts: drug product development

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15

Penedo, Maria Simões. "Novel shape in scored orodispersible tablets applying Design of Experiments." Master's thesis, 2017. http://hdl.handle.net/10451/36072.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2017<br>Drug Delivery Systems (DDS) are a strategic tool that has become increasingly sophisticated over the years. Their main contributions involve expanding the life cycle of pharmaceutical products, by improving the administration process according to the patient’s needs. Since the drug delivery through oral route still represents the most common and preferred way of drug administration, our work of study relies on the development of orodispersible tablets (ODTs). This dosage form pr

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16

Uslu, Sibel. "Formulation development and characterization of liquisolid tablets containing clozapine." Thèse, 2014. http://hdl.handle.net/1866/11571.

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L’objectif de ce projet était de développer une formulation liquisolide (LS) de clozapine ayant des propriétés de dissolution améliorées et évaluer sa stabilité et ainsi que sa robustesse à la modification d’excipients. Le propylène glycol (PG), la cellulose microcrystalline (MCC) et le glycolate d’amidon sodique (SSG) ont été utilisés respectivement en tant que véhicule liquide non volatile, agent de masse et agent désintégrant pour la préparation de comprimés LS. Le dioxyde de silicium colloïdal (CSD), le silicate de calcium (CS) et l'aluminométasilicate de magnésium (MAMS) ont été choisis c

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17

Chen, Shu-Chuan, and 陳淑娟. "A Study on Formulation of Orally Rapidly Disintegrating Chlorzoxazone Tablets." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/84986907985990809475.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>95<br>Chlorzoxazone is a muscle relaxant of central nervous system. It is used in the treatment of lumbago, shoulder ache, nerve ache, reduction the symptom of muscle ache, muscle convulsion and muscle tetanus after sports. Orally rapidly disintegrating tablets are solid dosage forms that disintegrate in the oral cavity leaving an easy-to-swallow residue. A statistical factorial experimental design was used to optimize the formulation of orally rapidly disintegrating chlorzoxazone tablets. A 23 experimental design was employed to evaluate the disintegration of the o

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18

Hsu, Chu-Ping, and 徐珠萍. "A Study on Formulation of Orally Rapidly Disintegrating Gliclazide Tablets." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/84082990939962604152.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>93<br>Orally rapidly disintegrating tablets are solid dosage forms that disintegrate in the oral cavity leaving an easy-to-swallow residue. When such tablets are placed in the oral cavity, saliva quickly penetrates into the pore to cause rapidly tablet disintegration. A direct compression method was used to prepare the tablet containing gliclazide as an oral hypoglycemic drug. Gliclazide is an oral hypoglycemic drug, belonging to second-generation sulphonylureas, which is used in type 2 diabetes. It has been suggested that due to its short-term acting, gliclazide ma

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19

Chen, Ya-Chuan, and 陳雅娟. "A Study on Formulation of Orally Rapidly Disintegrating Ramipril Tablets." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/07709915904786679579.

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碩士<br>高雄醫學大學<br>藥學研究所碩士在職專班<br>94<br>Ramipril is a strong and longterm angiotensin converting enzyme inhibitor. It is used in the treatment of hypertension, heart failure, myocardial infarction, reduction the dangerous of stroke and death. Orally rapidly disintegrating tablets are solid dosage forms that disintegrate in the oral cavity leaving an easy-to-swallow residue. A statistical factorial experimental design was used to optimize the formulation of orally rapidly disintegrating ramipril tablets. A 32 experimental design was employed to evaluate the disintegration of the orally rapidly dis

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20

Weng, Ling-Lun, and 翁翎倫. "Formulation design of tamsulosin hydrochloride orally disintegrating sustained-release tablets." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/25599816557485335781.

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21

Joshi, Anjali. "Development and Evaluation of Fixed Dose Combination Orally Disintegrating Tablets of Antiretroviral Drugs for Pediatrics." 2012. http://digital.library.duq.edu/u?/etd,162264.

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The thesis work entails a bench-to-bedside translational research approach to the development of pediatric fixed dose combination of zidovudine/lamivudine/nevirapine (60/30/50mg) orally disintegrating tablets. A simple and cost-effective, direct compression method was used. Preformulation studies that included analytical and bio-analytical assay development, excipient selection and characterization of drug-excipient interaction for initial formulation were conducted. Response surface methodology was utilized to optimize the formulation in terms of disintegration time and crushing strength. Sta

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