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Journal articles on the topic 'Orally Disintegrating Tablets (ODTs)'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Eremin, V. A., E. V. Blynskaya, and V. V. Bueva. "Orally disintegrating tablets: mechanisms, preparation methods, problems and achievements." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 6 (December 19, 2023): 25–32. http://dx.doi.org/10.33920/med-13-2306-03.

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The oral route of drug administration is considered one of the preferred delivery methods. In recent years, orally disintegrating tablets (ODTs) have become convenient pharmaceutical dosage forms, especially for specific patient populations such as pediatric, geriatric, and psychiatric patients with dysphagia. Rapid disintegration and increased bioavailability are some of the essential characteristics of ODTs that make them superior to other traditional pharmaceutical dosage forms. Orally disintegrating tablets are pills that disintegrate within a few seconds after being placed in the oral cav

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Bafail, Rawan SM. "Disintegration testing for orally disintegrating tablets (ODTs): An overview." Tropical Journal of Pharmaceutical Research 22, no. 11 (2024): 2399–406. http://dx.doi.org/10.4314/tjpr.v22i11.21.

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Prescribing orally disintegrating tablet (ODT) dosage form is a common practice. For several populations, including geriatrics and pediatrics, ODTs are one of the most desired dosage forms. They are solid dosage forms designed to disintegrate or dissolve very quickly in contact with saliva as soon as they are placed in oral cavity of a patient. According to United States Pharmacopeia (USP), every dosage form has to pass some quality control tests to ensure uniformity and performance of this dosage form. For ODTs, disintegration test is fundamental to ascertain time required for tablets to brea

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Shashank, Khailkhura, Singh Bhavana, Joshi Deepika, and Semwal Nidhi. "Orally disintegrating tablet: A review." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 018–25. https://doi.org/10.5281/zenodo.7180875.

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Orally dispersive tablets are solid dosage forms that dissolve in the mouth in within 10 to 30 seconds, enabling waterless ingestion. The tablet dissolves quickly due to its fast breakdown, which also causes the effects to start acting quickly. ODTs can help patients with a variety of conditions, including pediatrics, geriatrics, psychosis, dysphagia, bedridden discomfort, comatose patients, young patients with undeveloped muscular and nervous systems, patients with hand tremors, and patients who travel often. It provides high stability, precise dosage, efficient manufacture, and smaller packi

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Eremin, V. A., and E. V. Blynskaya. "Modern approaches to assessing the quality of orally disintegrating tablets." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 6 (December 19, 2023): 8–17. http://dx.doi.org/10.33920/med-13-2306-01.

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Orally disintegrating tablets (ODTs) are the preferred and accepted solid dosage forms by patients. These tablets disintegrate in the oral cavity within a short period, providing an advantage for individuals who have difficulty swallowing. Quality control of ODTs can be achieved through measures such as friability, porosity, hardness, wetting time, water absorption capacity, in vitro disintegration test, and dissolution test. This article summarizes the advantages and in vitro quality control tests of orally disintegrating tablets.

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Shashank Khailkhura, Bhavana Singh, Deepika Joshi, and Nidhi Semwal. "Orally disintegrating tablet: A review." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 018–25. http://dx.doi.org/10.30574/wjbphs.2022.11.3.0124.

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Orally dispersive tablets are solid dosage forms that dissolve in the mouth in within 10 to 30 seconds, enabling waterless ingestion. The tablet dissolves quickly due to its fast breakdown, which also causes the effects to start acting quickly. ODTs can help patients with a variety of conditions, including pediatrics, geriatrics, psychosis, dysphagia, bedridden discomfort, comatose patients, young patients with undeveloped muscular and nervous systems, patients with hand tremors, and patients who travel often. It provides high stability, precise dosage, efficient manufacture, and smaller packi

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Mahrous, Gamal Mohamed, Mohamed Gabr Kassem, Mohamed Abbas Ibrahim, and Sayed Hassan Auda. "Formulation and evaluation of orally disintegrating clopidogrel tablets." Brazilian Journal of Pharmaceutical Sciences 52, no. 2 (2016): 309–18. http://dx.doi.org/10.1590/s1984-82502016000200009.

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ABSTRACT Recent advances in drug delivery systems have aimed to achieve better patient compliance. One of these advances is the formulation of orally disintegrating tablets (ODTs) that dissolve instantaneously, releasing drugs within a few seconds without the need of water. The main objective of this paper was to prepare and develop ODTs of clopidogrel. The ODTs were prepared by direct compression. The effect of three superdisintegrants, namely crospovidone, croscarmellose sodium, and sodium starch glycolate, using three different disintegration times on the dissolution rate was investigated.

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Dang, Yen N. T., Phuong H. L. Tran, and Thao T. D. Tran. "Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets." Recent Patents on Drug Delivery & Formulation 14, no. 1 (2020): 40–47. http://dx.doi.org/10.2174/1872211313666191029144038.

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Background: Natural materials have been encouraged in controlled drug release and improved drug bioavailability. Objective: This study aimed to develop a modification process for the use of a natural material, Ocimum gratissimum seeds (OGS), in Orally Disintegrating Tablets (ODTs). Methods: The OGS was investigated with four different modification processes including only milling, swelling, swelling/milling, and swelling/milling/incubation. The ODTs containing the modified OGS as a disintegrant were prepared by the wet granulation method. Furthermore, an evaluation to assess parameters of tabl

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Swarupa, Arvapalli* D. Swamy Shyamala. "ORAL DISINTEGRATION TABLETS – AN UPDATED REVIEW." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 03 (2019): 6926–34. https://doi.org/10.5281/zenodo.2617331.

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<em>The purpose of writing this review is Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. It is leads to development of orally disintegrating tablets. This disintegrates in the mouth in seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. The prepared tablets were evaluated for hardness, friability, disintegration time

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Iancu, Valeriu, Florentina Roncea, Radu George Cazacincu, and Dumitru Lupuleasa. "Preparation and evaluation of diclofenac sodium orally disintegrating tablets." Ovidius University Annals of Chemistry 27, no. 1 (2016): 58–61. http://dx.doi.org/10.1515/auoc-2016-0004.

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Abstract Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can be attained by addition of different varieties of excipients. Pharmaburst™ 500 is a co-processed excipient system which allows rapid disintegration and low adhesion to punches. The aim of the present study was to develop and evaluate 25 mg diclofenac sodium ODTs (orodispersible tablets) batches by direct compression method at different compression forces 10 kN (F1) and 20 kN (F2) and directly compressible excipients used in dif

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Kashiwagura, Yasuharu, Shota Takusagawa, Yasuyuki Ikematsu, Shimako Tanaka, Noriyuki Namiki, and Shinya Uchida. "Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods." Acta Pharmaceutica 73, no. 1 (2023): 107–19. http://dx.doi.org/10.2478/acph-2023-0007.

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Abstract This study aimed to elucidate the characteristics and pharmacokinetics of orally disintegrating tablets (ODTs) containing coenzyme Q10 (CoQ10) granules prepared by spray drying, hot-melting, and wet granulation. The hardness and disintegration times of CoQ10-ODTs containing 5 % crospovidone were 61.6–81.8 N and < 30 s, respectively; these values indicate that the as-prepared ODTs were adequate for clinical use. The hardness and disintegration times of all ODTs did not change significantly after a 28-day storage period at 30 °C/10 % relative humidity (RH), but storage under high tem

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Badgujar, Bhatu, and Atish Mundada. "The technologies used for developing orally disintegrating tablets: A review." Acta Pharmaceutica 61, no. 2 (2011): 117–39. http://dx.doi.org/10.2478/v10007-011-0020-8.

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The technologies used for developing orally disintegrating tablets: A reviewOrally disintegrating tablets (ODTs), also known as fast melts, quick melts, fast disintegrating and orodispersible systems, have the unique property of disintegrating in the mouth in seconds without chewing and the need of water and are thus assumed to improve patient compliance. Conventional methods like direct compression, wet granulation, moulding, spray-drying, freeze-drying and sublimation were used to prepare ODTs. New advanced technologies like Orasolv®, Durasolv®, Wowtab®, Flashtab®, Zydis®, Flashdose®, Oraqui

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Mohamed, Asmaa. "Orally disintegrating tablets: formulation, preparation, and quality control assessment." European Journal of Scientific Research and Reviews 1, no. 4 (2024): 212. http://dx.doi.org/10.5455/ejsrr.20241003063230.

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Orally disintegrating tablets (ODTs) are a new formulation that dissolves in saliva within seconds, and there is no need to drink water. Due to its many benefits, this dosage form is an effective way to administer active pharmacological substances, especially for pediatric, geriatric, psychiatric, paralyzed, and bedridden patients. ODTs have been shown to have superior patient compatibility and drug solubility in numerous studies that have compared this tablet form with conventional forms in vitro and in vivo. There are many substances used to achieve enhanced characteristics, including super

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Comoglu, Tansel. "Orally disintegrating tablets (ODTs): An innovative approach to tablet formulations." Macedonian Pharmaceutical Bulletin 68, no. 03 (2022): 25–26. http://dx.doi.org/10.33320/maced.pharm.bull.2022.68.03.009.

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A., Deevan Paul* P. Nagaraj E. Reshma T. Mahesh Y. Divyasree. "CHALLENGES IN NANOTECHNOLOGY DRUG DELIVERY SYSTEMS - STATE OF ART TECHNOLOGIES." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1550–58. https://doi.org/10.5281/zenodo.816203.

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The potential challenges to solve the poor solubility, limited chemical stability in vitro and in vivo after administration (i.e. short half-life), poor bioavailability and potentially strong side effects requiring drug enrichment at the site of action (targeting). This review describes the use of nanoparticulate carriers, developed in our research group, as one solution to overcome the dosage forms. The performance of ODTs depends on the technology used in their manufacture. The orally disintegrating property of these tablets is attributable to the quick ingress of water into the tablet matri

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Yi, Tingting. "Development and evaluation of mosapride citrate orally disintegrating tablets for dogs." Ciência Rural 46, no. 11 (2016): 2064–69. http://dx.doi.org/10.1590/0103-8478cr20160402.

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ABSTRACT: The purpose of the study was to prepare orally disintegrating tablets (ODTs) of mosapride citrate for dogs with fast disintegration and low cost. The ODTs were developed by varying the components and the ratio of excipients. A direct compression method was used. The properties of the ODTs, including hardness, friability, active ingredient content, and in vitro disintegration time, were investigated, and an economic analysis of the formulations was performed. For all formulations, friability was less than 1%, and the hardness varied from 37.69±4.08 to 48.73±5.62 N, which indicated tha

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Limpongsa, Ekapol, Peera Tabboon, Thaned Pongjanyakul, and Napaphak Jaipakdee. "Preparation and Evaluation of Directly Compressible Orally Disintegrating Tablets of Cannabidiol Formulated Using Liquisolid Technique." Pharmaceutics 14, no. 11 (2022): 2407. http://dx.doi.org/10.3390/pharmaceutics14112407.

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This study demonstrated the implementation of a liquisolid technique to formulate directly compressible orally disintegrating tablets (ODTs). Cannabidiol (CBD), a hydrophobic cannabinoid, was prepared as a liquisolid powder using microcrystalline cellulose–colloidal silicon dioxide as a carrier–coating material. Different liquid vehicles differing in their volatility, hydrophilicity, and viscosity were investigated. Each of the CBD–ODTs comprised CBD liquisolid powder (10 mg CBD), superdisintegrant, flavors, lubricant, and filler. The physical mixture (PM) ODT was prepared as a control. Ethano

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Dai, Xiaorong, Jiamin Wang, Bo Yan, et al. "A Novel Lactose/MCC/L-HPC Triple-Based Co-Processed Excipients with Improved Tableting Performance Designed for Metoclopramide Orally Disintegrating Tablets." Pharmaceutics 16, no. 7 (2024): 959. http://dx.doi.org/10.3390/pharmaceutics16070959.

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New co-processed excipients comprising lactose (filler and sweetener), microcrystalline cellulose (MCC, filler), and low-substituted hydroxypropyl cellulose (L-HPC, disintegrant and binder) were developed via solvent evaporation for the preparation of metoclopramide orally disintegrating tablets (MCP ODTs). Single-factor and Box–Behnken experimental designs were employed to optimize the formulation. The optimized formulation ratios were water: MCC: lactose (g/g) = 17.26:2.79:4.54:1. The results demonstrated that particles formed by solvent evaporation had superior flowability and compressibili

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Sangnim, Tanikan, and Kampanart Huanbutta. "Development and Evaluation of Astaxanthin Orally Disintegrating Tablets Prepared from Coprocessed Excipients for Use in the Elderly." Key Engineering Materials 859 (August 2020): 295–300. http://dx.doi.org/10.4028/www.scientific.net/kem.859.295.

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The world’s population is aging; therefore, conventional pharmaceutical dosage forms designed for adult are not suitable. Orally disintegrating tablets (ODTs) are innovative dosage forms designed to overcome the problem of difficulty in swallowing or dysphagia, which is a common problem among all age groups, especially the elderly. This study aimed to develop and assess ODTs loaded with astaxanthin and manufactured by direct compression method using different coprocessed pharmaceutical excipients, including F-Melt® Type C, F-Melt® Type M, and Pearlitol Flash®. The results found that the ODTs p

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Siddheshwar, Suhas Shivaji, Asmita Bhausaheb Ghorpade, Someshwar Dattatraya Mankar, and Santosh Bhausaheb Dighe. "Formulation and Drug Release Study of Rivaroxaban Oral Disintegrating Tablets Using Various Super-Disintegrants." International Journal of Experimental Research and Review 36 (December 30, 2023): 147–55. http://dx.doi.org/10.52756/ijerr.2023.v36.014.

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This study aims to improve Rivaroxaban's solubility, dissolution, and bioavailability. Orally disintegrating tablets (ODTs) made with super-disintegrants like crospovidone, sodium starch glycolate, and cross-carmellose sodium will do this. Tablet preparation used direct compression and formulation optimization with design expert software. After a thorough factorial design and evaluation of pre- and post-compression parameters, the F3 batch, which contained Rivaroxaban (7.97%), Crospovidone (3.59%), Croscarmellose sodium (5.18%), Sodium Starch Glycolate (5.18%), Lactose Anhydrous (31.08%), Mann

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Teaima, Mahmoud, Sandra Hababeh, Mai Khanfar, Fares Alanazi, Doaa Alshora, and Mohammed El-Nabrawi. "Design and Optimization of Pioglitazone Hydrochloride Self-Nanoemulsifying Drug Delivery System (SNEDDS) Incorporated into an Orally Disintegrating Tablet." Pharmaceutics 14, no. 2 (2022): 425. http://dx.doi.org/10.3390/pharmaceutics14020425.

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Pioglitazone Hydrochloride (PGZ) suffers from poor aqueous solubility. The aim of this research was to design orally disintegrating tablets with self-nanoemulsifying properties (T-SNEDDS) to improve the Pioglitazone solubility and dissolution rate. Three liquid self-nanoemulsifying systems (L-SNEDDS) were formulated and evaluated for transmittance percentage, emulsification time, particle size, Poly dispersity index (PDI), percentage of content, solubility and stability. The optimum L-SNEDDS formula was converted to a solidified self-nanoemulsifying drug delivery system (S-SNEDDS) by adsorptio

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Chinwala, Maimoona. "Recent Formulation Advances and Therapeutic Usefulness of Orally Disintegrating Tablets (ODTs)." Pharmacy 8, no. 4 (2020): 186. http://dx.doi.org/10.3390/pharmacy8040186.

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This review highlights the recent formulation advances (different methods of preparation involving various novel approaches) that have been advancing the use of ODT as a popular dosage form. Furthermore, the important characteristics of ODTs that are required for patient compliance and appropriate therapeutic benefit are discussed. In addition to conventional ODTs, ODTs formulated for controlled release of pharmaceuticals and taste masking are also discussed.

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Kota, Ramesh Babu, and Saravanan Kaliyaperumal. "Superporous Hydrogels as Super Disintegrants in Formulating Oral Disintegrating Tablets of Clozapine for the Treatment of Schizophrenia." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1716–21. http://dx.doi.org/10.25258/ijddt.14.3.66.

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In this study, clozapine was formulated as orally disintegrating tablets (ODTs) using a direct compression method, incorporating super porous hydrogels as superdisintegrants. The disintegration time, hardness, friability, and stability of these ODT formulations were systematically evaluated, along with detailed dissolution profiles. Surprisingly, friability measurements revealed values below 1%. All tablet formulations disintegrated completely within 1 minute, meeting the 3-minute disintegration time criterion specified by the USP for ODTs. Moreover, over 85% of the labeled clozapine content w

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Tawfik, Essam A., Mariagiovanna Scarpa, Hend E. Abdelhakim, et al. "A Potential Alternative Orodispersible Formulation to Prednisolone Sodium Phosphate Orally Disintegrating Tablets." Pharmaceutics 13, no. 1 (2021): 120. http://dx.doi.org/10.3390/pharmaceutics13010120.

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The orally disintegrating tablet (ODT) has shown vast potential as an alternative oral dosage form to conventional tablets wherein they can disintegrate rapidly (≤30 s) upon contact with saliva fluid and should have an acceptable mouthfeel as long as their weight doesn’t exceed 500 mg. However, owing to the bitterness of several active ingredients, there is a need to find a suitable alternative to ODTs that maintains their features and can be taste-masked more simply and inexpensively. Therefore, electrospun nanofibers and solvent-cast oral dispersible films (ODFs) are used in this study as po

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Palugan, Luca, Saliha Moutaharrik, Alessandra Maroni, et al. "Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs." Pharmaceutics 14, no. 10 (2022): 2054. http://dx.doi.org/10.3390/pharmaceutics14102054.

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To overcome difficulties in splitting, uneven breaking and inconsistent dosing frequently reported with scored tablets, a novel punch was proposed for the manufacturing of easy breakable tablets (EBTs). In this work, the performance of the EBT punch was investigated vs. a ridged one for traditional breakable tablets (TBTs) using a furosemide powder formulation for orally disintegrating tablets (ODTs). A Face Centered Central Composite Design was applied to investigate the influence of punch type, compaction force, tablet weight and press rotation speed on the mechanical properties of ODTs, the

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Alejandro, Blasco, Torrado Guillermo, and Peña M. Ángeles. "Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets." Pharmaceuticals 13, no. 5 (2020): 100. http://dx.doi.org/10.3390/ph13050100.

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This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The res

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A., Manoj Kumar Patro* Ali Osman Sarikaya Emre Erol Aldeniz Udaya Dude. "A Review On Orodispersible Tablets." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 881–92. https://doi.org/10.5281/zenodo.13785912.

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Pharmaceutical scientists are learning more about the physicochemical and biological factors that affect drug delivery systems' efficacy, which leads to an advancement in their sophistication. Due to improved patient compliance, orally disintegrating tablets (ODTs) have drawn a lot of attention in the last thirty years as a preferable substitute for traditional tablets and capsules. When placed on the tongue, ODTs—solid dosage forms containing medication—disintegrate quickly, often within a few seconds. The 1980s saw the introduction of ODT technologies' products to the market, whi

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Ghourichay, Mohammadali Poursharifi, Seyed Hossein Kiaie, Ali Nokhodchi, and Yousef Javadzadeh. "Formulation and Quality Control of Orally Disintegrating Tablets (ODTs): Recent Advances and Perspectives." BioMed Research International 2021 (December 24, 2021): 1–12. http://dx.doi.org/10.1155/2021/6618934.

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Orally disintegrating tablets (ODTs) rapidly disintegrate or dissolve in the oral cavity without using water. Demand for ODTs has increased, and the field has overgrown in the pharmaceutical industry and academia. It is reported that ODTs have several advantages over other conventional tablets. Since some of them are absorbed from the mouth, pharynx, and esophagus as the saliva passes down into the stomach, in such cases, the bioavailability of the drug improves meaningfully. Furthermore, the immediate release property of ODTs makes them a popular oral dosage form in patients with swallowing c

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Sarecka-Hujar, Beata, Karol Łyczak, Radosław Balwierz, and Andrzej Jankowski. "Evaluation of orally disintegrating tablets (ODTs) containing microspheres with losartan potassium." Annales Academiae Medicae Silesiensis 73 (February 28, 2019): 36–42. http://dx.doi.org/10.18794/aams/85227.

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Commey, Kindness L., Airi Enaka, Ryota Nakamura та ін. "Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate". Pharmaceutics 16, № 1 (2024): 82. http://dx.doi.org/10.3390/pharmaceutics16010082.

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Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs). This study reports on the development of a cyclodextrin (CD)-based orally disintegrating tablet (ODT) formulation for PB as an alternative to existing formulations. This is based on previous reports of the PB taste-masking potential of CDs and the suitability of ODTs for improving compliance in pediatric and dysphagic populations. In preliminary

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Ono, Asami, Takumi Tomono, Takuo Ogihara, Katsuhide Terada, and Kiyohiko Sugano. "Investigation of biopharmaceutical drug properties suitable for orally disintegrating tablets." ADMET and DMPK 4, no. 4 (2016): 335. http://dx.doi.org/10.5599/admet.4.4.338.

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<span style="color: black; font-family: 'Calibri','sans-serif'; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-GB; mso-fareast-language: DE; mso-bidi-language: AR-SA;" lang="EN-GB">The purpose of this study was to evaluate the biopharmaceutical drug properties suitable for orally disintegrating tablets (ODTs). The net charge at pH 7.4, log D<sub>6.5</sub>, the highest dose strength, solubility in water, dose number, and elimination t<sub>1/2</sub> of 57 ODT drugs and 113 drugs of immediat

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Szlęk, Jakub, Mohammad Hassan Khalid, Adam Pacławski, Natalia Czub, and Aleksander Mendyk. "Puzzle out Machine Learning Model-Explaining Disintegration Process in ODTs." Pharmaceutics 14, no. 4 (2022): 859. http://dx.doi.org/10.3390/pharmaceutics14040859.

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Tablets are the most common dosage form of pharmaceutical products. While tablets represent the majority of marketed pharmaceutical products, there remain a significant number of patients who find it difficult to swallow conventional tablets. Such difficulties lead to reduced patient compliance. Orally disintegrating tablets (ODT), sometimes called oral dispersible tablets, are the dosage form of choice for patients with swallowing difficulties. ODTs are defined as a solid dosage form for rapid disintegration prior to swallowing. The disintegration time, therefore, is one of the most important

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Yamada, Mizuki, Agata Ishikawa, Shun Muramatsu, et al. "Study of Orally Disintegrating Tablets Using Erythritol as an Excipient Produced by Moisture-Activated Dry Granulation (MADG)." Pharmaceuticals 15, no. 8 (2022): 1004. http://dx.doi.org/10.3390/ph15081004.

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Moisture-activated dry granulation (MADG) is an eco-friendly granulation method that uses a small amount of water and insoluble excipients to absorb moisture. MADG is expected to improve productivity and reduce costs. Erythritol, an excipient used for preparing orally disintegrating tablets (ODTs), has poor tabletability and is difficult to form into tablets by conventional methods, such as high-shear granulation (HSG) and direct compression. In this study, we optimized the manufacturing conditions for ODTs to improve the tabletability of erythritol using MADG. The disintegration time of table

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Bhakare, Shweta, and Ajay G. Pise. "Deep Insights into the Developmental Progress of Orally Disintegrating Tablet Formulation, Techniques, and Products: A Comprehensive Review." International Journal of Medical & Pharmaceutical Sciences 12, no. 05 (2022): 17–22. http://dx.doi.org/10.31782/ijmps.2022.12503.

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When it comes to the design of dosage forms, the ease of medication administration and patient compliance are given significant consideration. Recently developed and emerging technologies may be used to make durable, multifunctional tablets that have exceptional flavor masking properties and controlled release. It is possible to consume orally disintegrating tablets (ODTs) without drinking water since they break down in the mouth in less than 60 seconds and dissolve completely in the mouth. Rapid disintegration of the tablet results in rapid dissolving and, as a result, rapid beginning of acti

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Roman, Vaishnavi* Gaikwad Rutuja. "Development And Characterization of Lornoxicam Tablets Incorporating Banana Starch as A Superdisintegrating for Enhanced Dissolution." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2058–63. https://doi.org/10.5281/zenodo.15232534.

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Orally disintegrating tablets (ODTs) are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. ODTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, in which disintegrants are the key adjuvant. In recent years, several newer agents have been developed known as super-disintegrants. Super-disintegrants are used to improve the efficacy of solid dosage form and influence the release rate

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Comoglu, Tansel. "Orally disintegrating tablets (ODTs): a new approach to solid dosage forms." Macedonian Pharmaceutical Bulletin 66, no. 03 (2020): 95–96. http://dx.doi.org/10.33320/maced.pharm.bull.2020.66.03.047.

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ÇOMOĞLU, Tansel. "FARKLI SÜPER DAĞITICILARIN KETOPROFEN İÇEREN AĞIZDA DAĞILAN TABLETLERİN İN VİTRO KARAKTERİZASYON PARAMETRELERİ ÜZERİNDEKİ ETKİSİNİN DEĞERLENDİRİLMESİ." Ankara Universitesi Eczacilik Fakultesi Dergisi 48, no. 2 (2024): 10. http://dx.doi.org/10.33483/jfpau.1425266.

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Objective: Orally Disintegrating Tablets (ODTs) have revolutionized pharmaceutical drug delivery, offering a patient-friendly alternative for those struggling with conventional tablet swallowing. This study delves into the impact of superdisintegrants (crospovidone, sodium starch glycolate, and croscarmellose sodium) on the in vitro characterization of Ketoprofen-containing ODTs. ODTs are designed to rapidly disintegrate in the oral cavity without water, enhancing patient compliance, ensuring faster therapeutic onset, and providing convenience. Material and Method: The micromeritic properties

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Hemant Agrawal. "To prepare and evaluate orodispersible tablet of anti-inflammatory drug." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 165–73. http://dx.doi.org/10.30574/wjbphs.2022.12.1.0161.

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Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop orally disintegrating tablets (ODTs) with improved patient compliance and convenience. Orodispersible tablets are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Orodispersible tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes the various formulation aspects, dis

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Hemant, Agrawal. "To prepare and evaluate orodispersible tablet of anti-inflammatory drug." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 165–73. https://doi.org/10.5281/zenodo.7602741.

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Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop orally disintegrating tablets (ODTs) with improved patient compliance and convenience. Orodispersible tablets are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Orodispersible tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes the various formulation aspects, dis

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DEMİRTÜRK, Esra, Deniz ONAN, and Tilbe ÇEVİKELLİ. "Evaluation of Orally Disintegrating Tablet Formulations in The Treatment of Oral Mucositis." Cukurova Anestezi ve Cerrahi Bilimler Dergisi 6, no. 3 (2023): 406–10. http://dx.doi.org/10.36516/jocass.1355644.

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Aim: Orally disintegrating tablets (ODT) are widely used dosage forms with high patient compliance, which preferred in the treatment of many diseases currently. In this study we aimed to develop an orally disintegrating tablet formulation can be preferred in the treatment of oral mucositis, which often occurs after chemotherapy during cancer treatment. Methods: Lidocaine hydrochloride, which is a local anesthetic substance, was used as active pharmaceutical ingredient to obtain ODT formulation for the treatment of oral mucositis. ODTs were prepared by direct compression technique and cro

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R, Yogaraj, Surinder Kaur, and Padmaa M. Paarakh. "A Brief Introduction on Oro Dispersible Tablets." April-May 2023, no. 33 (April 10, 2023): 9–16. http://dx.doi.org/10.55529/jcpp.33.9.16.

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Oro dispersible tablets (ODTs), which have improved solubility and stability over the past three decades, have drawn a lot of interest as a superior alternative to traditional tablets and capsules. ODTs—solid dosage forms with medications that dissolve on the tongue fast, usually in a few seconds. New ODT technologies answer a wide range of pharmaceutical preparations and patient needs, to enhance the lifecycle management to straightforward dosage regimen for dysphagic, children, old, and mentally imbalanced patients. Methods for administering orally dispersible drugs are frequently used to im

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Ahmed, Nusrat, Jesmin Akter, and Sabrina Rahman Archie. "Formulation and In-Vitro Evaluation of Orally Disintegrating Tablets (ODTs) of Tramadol Hydrochloride." Journal of Drug Delivery and Therapeutics 11, no. 3-S (2021): 1–6. http://dx.doi.org/10.22270/jddt.v11i3-s.4875.

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Since orally disintegrating tablets (ODTs) of tramadol hydrochloride are not available in the market, so an attempt has been taken to formulate and evaluate ODT preparation of tramadol hydrochloride. In this present work, direct compression was the technique used for preparing ODT using superdisintegrants like croscarmellose sodium, sodium starch glycolate and crospovidone at different concentrations. Prepared formulations were evaluated for various quality parameters- angle of repose, Carr’s index, Hausner ratio, weight variation, friability, hardness, drug content, dispersion time, wetting t

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Suhery, Wira Noviana, Armon Fernando, and Buddy Giovanni. "Perbandingan Metode Granulasi Basah dan Kempa Langsung Terhadap Sifat Fisik dan Waktu Hancur Orally Disintegrating Tablets (ODTs) Piroksikam." Jurnal Sains Farmasi & Klinis 2, no. 2 (2016): 138. http://dx.doi.org/10.29208/jsfk.2016.2.2.65.

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Telah dilakukan penelitian mengenai perbandingan penggunaan metode granulasi basah dan kempa langsung terhadap sifat fisik dan waktu hancur orally disintegrating tablets (ODTs) piroksikam. Penelitian ini bertujuan untuk membandingkan metode pembuatan ODTs piroksikam yang menghasilkan sifat fisik tablet dan waktu hancur yang paling baik. Komposisi formula pada metode granulasi basah dan cetak langsung sama tiap tabletnya yaitu Piroksikam 20 mg, Primellose® 5%, PVP K30 1%, Mg stearat 1%, Manitol 10%, dan Comprecel® ad 175 mg. Tablet ODTs kemudian dievaluasi sifat fisiknya yang meliputi keseragam

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Takagi, Toshihide, Takato Masada, Keiko Minami, Makoto Kataoka, and Shinji Yamashita. "Development of an In Vitro Methodology to Assess the Bioequivalence of Orally Disintegrating Tablets Taken without Water." Pharmaceutics 15, no. 9 (2023): 2192. http://dx.doi.org/10.3390/pharmaceutics15092192.

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To assess the probability of bioequivalence (BE) between orally disintegrating tablets (ODTs) taken without water and conventional tablets (CTs) taken with water, an in vitro biorelevant methodology was developed using the BE Checker, which reproduces fluid shifts in the gastrointestinal tract and drug permeation. In addition to the fluid shift from the stomach to the small intestine, the process of ODT disintegration in a small amount of fluid in the oral cavity and the difference in gastric emptying caused by differences in water intake were incorporated into the evaluation protocol. Assumin

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Chaity, Nusrat Islam, Sabrina Rahman Archie, and Nusrat Ahmed. "Preparation and In vitro Evaluation of Orally Disintegrating Tablets (ODTs) of Alprazolam." Dhaka University Journal of Pharmaceutical Sciences 18, no. 1 (2019): 129–33. http://dx.doi.org/10.3329/dujps.v18i1.41430.

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Joseph, Femi, and K. Premaletha. "Natural Superdisintegrants for the Formulation of Orally Disintegrating Tablets." International Journal of Research and Review 8, no. 11 (2021): 123–28. http://dx.doi.org/10.52403/ijrr.20211117.

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Oral route is the most favoured and preferred route for the administration for most of the dosage forms because it offers so many advantages over other routes of administration. Sometimes the oral route is associated with a problem called dysphagia. This condition can be seen in a population of paediatric, geriatric, patients with neurological problems, bedridden patients and so on. In order to overcome such a problem orodispersible tablets will be a better choice, because it will disintegrate within seconds when comes in contact with saliva. Natural agents offers so many advantages like nonto

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Fatima, Syeda Sara, Farya Zafar, Huma Ali, et al. "Development and characterisation of orally disintegrating flurbiprofen tablets using SeDeM-ODT tool." PLOS ONE 19, no. 10 (2024): e0309894. http://dx.doi.org/10.1371/journal.pone.0309894.

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In this study, SeDeM–ODT parametric tests were performed to determine the use of ludipress as a directly compressible tableting excipient for the development of a flurbiprofen orally disintegrating tablet. The preformulation features of different formulations (F1 –F9) were analyzed by the SeDeM–ODT tool which showed that all the powder blends were appropriate for direct compression since all the blends had index of good compressibility and bucodispersibility (IGCB) values above 5, signifying direct compression is the most appropriate method. The powder blend of the optimized formulation was as

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Krishna, Manju Pandey, and Amresh Gupta. "Fast dissolving tablets: Opportunity in herbal drug delivery system." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 102–13. http://dx.doi.org/10.30574/wjarr.2024.21.1.2657.

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The polyherbal preparation's pharmacological and phytochemical properties have been used all over the world. Single or multiple herbs (polyherbal) are utilized for treatment in Ayurveda. The Sarangdhar Samhita, a work of Ayurvedic literature, emphasized the idea of polyherbalism as a means of enhancing therapeutic efficacy. Individual plants' active phytochemical components are insufficient to produce the desired therapeutic effects. The medicinal effects and toxicity are improved when different herbs are combined in a specific ratio. Comforts of drug administration and patient compliance are

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Krishna, Pandey Manju, and Gupta Amresh. "Fast dissolving tablets: Opportunity in herbal drug delivery system." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 102–13. https://doi.org/10.5281/zenodo.13120020.

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The polyherbal preparation's pharmacological and phytochemical properties have been used all over the world. Single or multiple herbs (polyherbal) are utilized for treatment in Ayurveda. The Sarangdhar Samhita, a work of Ayurvedic literature, emphasized the idea of polyherbalism as a means of enhancing therapeutic efficacy. Individual plants' active phytochemical components are insufficient to produce the desired therapeutic effects. The medicinal effects and toxicity are improved when different herbs are combined in a specific ratio. Comforts of drug administration and patient compliance are

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Singh, Jatinderpal, Rajeev Garg, and Ghanshyam Das Gupta. "Enhancement of Solubility of Lamotrigine by Solid Dispersion and Development of Orally Disintegrating Tablets Using 32 Full Factorial Design." Journal of Pharmaceutics 2015 (October 27, 2015): 1–8. http://dx.doi.org/10.1155/2015/828453.

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Present investigation deals with the preparation and evaluation of orally disintegrating tablets (ODTs) of lamotrigine using β-cyclodextrin and PVP-K30 as polymers for the preparation of solid dispersion which help in enhancement of aqueous solubility of this BCS CLASS-II drug and sodium starch glycolate (SSG) and crospovidone as a superdisintegrating agent, to reduce disintegration time. The ODTs were prepared by direct compression method. Nine formulations were developed with different ratios of superdisintegrating agents. All the formulations were evaluated for disintegration time, weight v

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Refaat, Ahmed, Magda Sokar, Fatma Ismail, and Nabila Boraei. "A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets." Acta Pharmaceutica 66, no. 4 (2016): 515–32. http://dx.doi.org/10.1515/acph-2016-0041.

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Abstract Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylp

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