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Dissertations / Theses on the topic 'ORF2 protein'

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Published: 15 June 2024

Last updated: 31 July 2025

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1

Guo, Hailong. "Antigenic epitope composition and protectivity of avian hepatitis E virus (avian HEV) ORF2 protein and vertical transmission of avian HEV." [Ames, Iowa : Iowa State University], 2006.

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2

Ankavay, Maliki. "Étude des modifications post-traductionnelles de la protéine de capside ORF2 du virus de l'hépatite E (HEV)." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S013.

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L’infection par le virus de l’hépatite E (HEV) est un problème majeur de santé publiquequi touche plus de 20 millions de personnes et tue environ 70 000 chaque année à travers lemonde. Le HEV est la cause majeure d’hépatite virale aiguë dans le monde. En France, laséroprévalence du HEV est de 22,4% dans la population générale. Ce virus se transmet parvoie féco-orale ou par consommation de viande contaminée mal cuite. Très récemment, nousavons décrit un système de culture cellulaire permettant d’amplifier efficacement le HEV. Cesystème représente un outil unique pour caractériser les différente

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3

Ferrié, Martin. "Étude de la maturation protéolytique et du trafic intracellulaire de la protéine de capside ORF2 du virus de l'hépatite E (HEV)." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS067.

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L'infection par le virus de l'Hépatite E (HEV) est un problème majeur de santé publique qui toucherait 100 millions de personnes et tuerait 100 000 personnes chaque année dans le monde. Le HEV est la première cause d'hépatite aigüe dans le monde. En France, la séroprévalence s'élève à 22,4%. Ce virus se transmet par voie féco-orale ou par la consommation de viande contaminée mal cuite. Au cours de ma thèse, je me suis intéressé plus particulièrement à la protéine de capside ORF2, qui est l'unité structurale des particules virales et un acteur central du cycle infectieux du HEV. La protéine ORF

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4

Horridge, Jackie J. "RNA-protein interactions of the adenovirus proteins E1B 55K and E4 Orf6." Thesis, University of Warwick, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322435.

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5

Baghbadorani, G. Ahmadian. "Analysis of the utilisation of second ORFs in pneumovirus mRNA." Thesis, University of Warwick, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323416.

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6

Chand, Puran. "Molecular and immunological characterisation of a major envelope protein of capripoxvirus." Thesis, University of Surrey, 1992. http://epubs.surrey.ac.uk/2774/.

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Analysis of the proteins of capripoxvirus (KS-1) revealed a 32kd protein that is one of the major structural proteins of the virus and is localised in the virus envelope. Monospecific serum prepared against the 32kd envelope protein neutralised the virus indicating that this protein contains neutralising epitopes. Lymphocyte proliferation studies, using the 32kd protein and peripheral blood mononuclear cells from capripoxvirus (KS-i) vaccinated sheep, showed that this protein strongly induced cellmediated immune responses. The 32kd protein is capripoxvirus specific and induced antibodies in ea

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7

Koyuncu, Emre. "Expression, Purification, And Functional Analysis Of Adenovirus Type 5 E4 Orf3 Protein." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605415/index.pdf.

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In this study, structural and functional aspects of adenovirus type 5 (Ad5) E4orf3 protein were analyzed by biophysical and biochemical methods. Ad5 is one of the mostly used gene therapy vectors to date. However, some of its proteins possess oncogenic potential and their presence comprises safety risks. E4orf3 is one of the oncoproteins of Ad5. It also takes important roles in viral infection, and is beneficial for therapy vectors. Therefore, understanding the functions of E4orf3 is very important for developing efficient and safe adenovirus vectors. Most of the present knowledge about the f

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8

Bowers, Laura Yvonne. "Orf protein modulates phage and bacterial pathways of genetic recombination." Thesis, Durham University, 2008. http://etheses.dur.ac.uk/2345/.

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The emergence of novel pathogenic organisms due to the acquisition of virulence determinants from bacteriophages has generated significant interest in the pathways responsible for genomic rearrangements. Phageλ encodes its own recombination system, the Red system, comprising Exo, β and γ proteins. In addition,λ encodes another recombinase, Orf, which participates in the initial stages of genetic exchange and supplies a frmction equivalent to that of the Escherichia coli RecFOR proteins. This thesis focuses on determining the function of Orf in phage and bacterial recombination pathways by anal

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9

Liedeman, Kerwin. "Transient transgene expression of human Coronavirus nl63 orf3 protein in a baculovirus system." University of the Western Cape, 2020. http://hdl.handle.net/11394/8042.

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>Magister Scientiae - MSc<br>Insect-derived baculoviruses have been used extensively as a safe and versatile research model for transgenic protein expression. Preclinical studies have revealed the promising potential of Baculoviruses as a delivery vector for a variety of therapeutic applications, including vaccination, tissue engineering and cancer treatments. Coronaviruses are enveloped viruses containing linear, non-segmented ribonucleic acid. Human coronavirus NL63 was first discovered in the Netherlands in January 2004, where a 7-month-old girl presented with an acute respiratory tract inf

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10

Yadav, Kush Kumar. "Genotype 1 hepatitis E virus (HEV) ORF4 protein enhances genotype 3 HEV replication." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574781581580768.

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11

Ali, Ahmed Said. "Investigation of epoxide hydrolase activity in Saccharomyces cerevisiae ORF YNR064c protein." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203473.

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12

Dickinson, Victoria Jane. "The cloning and subcellular localisation of maize streak virus ORF V1." Thesis, University of Hull, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321050.

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13

Mo, Min, and n/a. "Characterization of an Orf virus RING-H2 protein, B5L : a mimic of cellular anaphase promoting complex subunit 11." University of Otago. Department of Microbiology & Immunology, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090220.085825.

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The anaphase promoting complex (APC/C) is an ubiquitin ligase that is an essential regulator of multiple steps in the cell cycle. The complex consists of at least 12 subunits with a catalytic core formed by a scaffold protein, APC2, and a RING-H2 protein, APC11. The Parapoxvirus, Orf virus (OV), encodes a RING-H2 protein, B5L, with clear sequence similarities to APC11. The disruption of APC/C function leads to pre-mature entry into S phase and a delayed M phase exit and, potentially, apoptosis. This investigation explored the functional significance of the similarity between B5L and APC11 and

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14

Butarbutar, Nunut. "Analysis of yeast codon usage patterns using the movable ORF collection /." Online version of thesis, 2007. http://hdl.handle.net/1850/5700.

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15

Laitinen, Saara. "Family of human oxysterol binding protein homologues : ORP2 is a new regulator of cellular lipid metabolism." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kansa/vk/laitinen/.

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16

Öhrmalm, Christina. "Functional Characterization of the Cellular Protein p32 : A Protein Regulating Adenovirus Transcription and Splicing Through Targeting of Phosphorylation." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6794.

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<p>Cellular processes involved in the conversion of the genetic information from DNA into a protein are often regulated by reversible phosphorylation reactions. By modulating the phosphorylated status of key proteins their activity can either be enhanced or repressed. In this thesis I have studied the significance of phosphorylation in the regulation of transcription and splicing using human adenovirus as a model system.</p><p>The results show that the activity of the cellular SR family of splicing enhancer or repressor proteins are reduced in adenovirus infected nuclear extracts by a virus-in

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17

D'Angelillo, Anna. "Studio dell'attività biologica della proteina ORF-A del virus dell'immunodeficienza felina." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423592.

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Feline Immunodeficiency Virus (FIV), a non-primate lentivirus, causes an immunodeficiency syndrome in domestic cats that is strikingly similar to AIDS in humans. Although diverse in term of evolution, FIV is similar to Human Immunodeficiency Virus Type-1 (HIV-1) in many respects including genome organization, target cells infected in vivo, course of infection and disease state. Thus, for these reasons, FIV represents an attractive model for AIDS research. Similarly to HIV-1 and other lentivirus, the FIV genome encodes three large open reading frame gag, pol, env that encode for the structural

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18

Tan, Joanne Li-Ching, and n/a. "Development of Orf virus as a vaccine vector : manipulation of structural proteins for surface display of immunogenic peptides." University of Otago. Department of Microbiology & Immunology, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090427.144304.

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Orf virus (ORFV) has the potential to be developed as a vaccine vector. Its ability to stimulate non-specific as well as specific immune responses in permissive and non-permissive hosts stands it in good stead to be utilised as such a tool. The fusion of immunogenic peptides to vaccinia virus (VACV) structural proteins have been shown to improve their immunogenicity due to presentation of the foreign antigens in a particulate form that can stimulate both B and T cells. The aims of this study were to fuse foreign antigens to ORFV structural proteins to demonstrate proof-of-concept that such sur

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19

Diekmann, Ulrike Verfasser], and Lothar [Akademischer Betreuer] [Jänsch. "Characterisation of the KSHV protein ORF20 and its role in innate immunity / Ulrike Diekmann ; Betreuer: Lothar Jänsch." Braunschweig : Technische Universität Braunschweig, 2019. http://d-nb.info/1179909984/34.

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20

Diekmann, Ulrike [Verfasser], and Lothar [Akademischer Betreuer] Jänsch. "Characterisation of the KSHV protein ORF20 and its role in innate immunity / Ulrike Diekmann ; Betreuer: Lothar Jänsch." Braunschweig : Technische Universität Braunschweig, 2019. http://d-nb.info/1179909984/34.

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21

Estmer, Nilsson Camilla. "Viral Control of SR Protein Activity." Doctoral thesis, Uppsala : Acta Universatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5124-1/.

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22

White, Ian Alexander. "Hematopoietic stem cell expansion : under serum free and cytokine-limited conditions using primary endothelial cells transfected with the adenoviral E4-ORF1 gene /." Access full-text from WCMC, 2009. http://proquest.umi.com/pqdweb?did=1692100331&sid=5&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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23

Mardegan, Catarina. "Caracterização funcional da ORF XAC0239 de Xanthomonas citri subsp. citri /." Jaboticabal, 2018. http://hdl.handle.net/11449/155873.

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Orientador: Maria Inês Tiraboschi Ferro<br>Coorientador: Helen Alves Penha<br>Banca: José Belasque Júnior<br>Banca: Daniel Guariz Pinheiro<br>A Xanthomonas citri subsp. citri (Xac) é a bactéria causadora da doença cancro cítrico. A doença atinge todas as variedades comerciais de citros e, o entendimento da relação fitopatogênica permitirá conhecer formas mais eficientes de controle da bactéria. Com o sequenciamento e análise do genoma e transcriptoma da Xac, foram identificadas ORFs que, provavelmente, estão envolvidas em processos de ataque e colonização da bactéria. Para iniciar a caracteriz

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24

Deane, David Leslie. "The characterisation of a GM-CSF and IL-2 inhibitory protein encoded by Orf virus." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23323.

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In this study, the gene encoding the GM-CSF inhibitory factor (GIF) was isolated and mapped to the right terminal quarter of the orf virus genome. The orf virus GIF cDNA was expressed as a secreted protein in Chinese hamster ovarian cells as detected by GM-CSF inhibition ELISA. Recombinant GIF was purified by ovine GM-CSF affinity chromatography and gel filtration. Sequence analysis of the 20 N-terminal amino acids was performed on the purified GIF. The GIF gene encodes a 28 kDa protein that exhibits 32% amino acid sequence similarity to the predicted sequence of the A41L gene product encoded

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25

Melling, Michael [Verfasser], and Thomas [Akademischer Betreuer] Dobner. "The influence of SUMOylation on the adenoviral early region 4 protein Orf6/7 / Michael Melling ; Betreuer: Thomas Dobner." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2018. http://d-nb.info/1163013692/34.

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26

Craft, Jennifer Leigh. "Generating an expression construct and soluble protein for characterization studies of a putative RNA m5C methyltransferase, yeast ORF YNLO22c." Virtual Press, 2005. http://liblink.bsu.edu/uhtbin/catkey/1319220.

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RNA m5C methyltransferases are a group of enzymes that catalyze the transfer of a methyl group to a cytosine nucleotide of RNA. Only two of these enzymes have been well characterized: Fmu from E. coli and Trm4p from S. cerevisiae. YNLO22c is one of three ORFs identified in S. cerevisiae that have homology with both known and putative RNA m5C methyltransferases, but its encoded protein, YNLO22p, has not been confirmed to have enzyme activity. Verifying that YNLO22c encodes an RNA m5C methyltransferase will require adequate amounts of soluble YNLO22p for enzyme assays. A bacterial expression pla

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27

Scholz, Kai. "Immunmodulation durch Parapocken-Viren: Identifikation und Analyse funktionaler Viruskomponenten." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1061969873968-07930.

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Fusionspeptid-, Redox-, Viruscore- und sonstige Proteine. Alle analysierten Single ORF (SO)-VVOV Rekombinanten vermittelten einen signifikanten Schutz vor einer tödlichen Belastung mit Aujeszky-Virus. Zwei der Rekombinanten (SO 93-, SO 94-VVOV) enthalten ORFs, die für ATI/Fusionspeptid-Proteine kodieren. In SO 19- und SO 70-VVOV sind dagegen für Redoxproteine kodierende ORFs integriert. Weiterführende Untersuchungen zeigten, dass SO 94- und SO 19-VVOV in zwei weiteren Modellsystemen immunstimulatorisch aktiv sind. Im Baculo-Virussystem exprimierte Proteine waren nur in Kombination mit Vaccinia

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28

Key, Kijona Farthing. "Molecular characterization of the major envelope protein of porcine reproductive and respiratory syndrome virus (PRRSV) and evaluation of its use for a diagnostic assay, vaccine development, and the examination of quasispecies evolution." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/27282.

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Porcine reproductive and respiratory syndrome (PRRS) is a viral disease that has devastated the global swine industry since the mid 1980s. Although modified live vaccines (MLVs) are typically used for the prevention of clinical disease, they are not always fully effective. Additionally, acute PRRS outbreaks, characterized by more severe clinical signs, have appeared in herds that were previously vaccinated. In this dissertation, we further analyzed the pathogenesis of PRRSV through genetic characterization, assay development, and quasispecies evaluation using the PRRSV ORF5 gene while also

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29

Chi, Xiuling. "BIOSYNTHETIC PATHWAY OF THE AMINORIBOSYL COMPONENT OF LIPOPEPTIDYL NUCLEOSIDE ANTIBIOTICS." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/23.

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Several lipopeptidyl nucleoside antibiotics that inhibit bacterial translocase I (MraY) involved in peptidoglycan cell wall biosynthesis contain an aminoribosyl moiety, an unusual sugar appendage in natural products. A-90289 and muraminomicin are the two representative antibiotics that belong to this family. Bioinformatic analysis of the biosynthetic A-90289 gene clusters revealed that five enzymes are likely involved in the assembly and attachment of the aminoribosyl unit. These enzymes of A-90289 are functionally assigned by in vitro characterization. The results reveal a unique ribosylation

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30

Huang, Yu-Liang, and 黃有良. "Immuno-protection of porcine circovirus type 2 ORF1 and ORF2 recombinant protein." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/12062489232254298987.

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碩士<br>國立屏東科技大學<br>獸醫學系<br>92<br>Porcine circovirus type 2 (PCV2) has been reported to be associated with the development of porcine multisystemic wasting syndrome (PMWS), which often results in the death of pigs due to secondary infection. The genome of PCV2 might contain eleven open reading frames (ORFs). ORF 1 and ORF 2 encode the replication-associated proteins and capsid protein, respectively. In this study, the immunogenicity of E. coli-expressed PCV2 ORF 1 and PCV2 ORF 2 and baculovirus-expressed PCV2 ORF 2 were compared in mice and pigs. In addition, ORF 2 gene with Pseudomonas aerugino

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31

Chen, Yu-San, and 陳裕森. "Cloning, Expression, and Antigenesity Analysis of the PCV2 Coat Protein Gene (ORF2)." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/99558729710906776501.

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碩士<br>國立宜蘭大學<br>生物技術研究所碩士班<br>94<br>Porcine circovirus type 2 belongs to the Circoviridae family. PCV2 is a small, nonenveloped virus with a single-stranded circular DNA genome of about 1.76 kb. The open reading frame ORF2 of the PCV2 genome encodes the immunogenic structural capsid protein. The expression for this immunogenic protein using full length ORF2 DNA was difficult to obtain in large quantity in prokaryotic expression system. Therefore, an alternative approach was to divide ORF2 DNA into three segments for expression, F1, F2, and F3. It was discovered that expression in E.coli w

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32

"Analysis Of The Line-1 Orf2 Protein Using An Evolutionarily-informed Genetic Approach." Tulane University Digital Library, 2016.

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Long Interspersed Element 1(LINE1 or L1), along with the parasitic Short Interspersed Element (SINE), are the only two currently active retrotransposons in the human genome. These genetic elements are capable of causing DNA damage through their mobilization and the enzymatic activities of the L1-encoded Open Reading Frame 2 (ORF2) protein (ORF2p). The L1 ORF2p contains four annotated domains important to retrotransposition. These include the endonuclease (EN) and reverse transcriptase (RT) domains, as well as the Z domain and the cysteine rich domain (Cys). While much is known about the enzyma

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33

Chowdhury, Soumya Roy. "Molecular Characterization Of Movement Protein Encoded By ORF-1 Of Sesbania Mosaic Virus (SeMV)." Thesis, 2010. https://etd.iisc.ac.in/handle/2005/1465.

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34

Chowdhury, Soumya Roy. "Molecular Characterization Of Movement Protein Encoded By ORF-1 Of Sesbania Mosaic Virus (SeMV)." Thesis, 2010. http://hdl.handle.net/2005/1465.

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35

Tseng, Yeu-Yang, and 曾宇揚. "Functional analysis of orf virus OV20.0 protein isoforms." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/19898262310985605669.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>103<br>Orf virus (ORFV) infection causes pustule and ulceration around muzzle of small ruminants. Although it often occurs with low mobility and mortality, orf may be fatal in juvenile hosts. ORFV, belonging to genus parapoxvirus of the family Poxviridae, is an enveloped virus with double-stranded DNA genome. OV20.0 protein is produced from OV20.0L gene, an E3L ortholog, which is conserved in the genome of most members in Poxviridae. Vaccinia E3 (VV E3) has been studied extensively in these days; however sequences of VV E3 shares low identity with those of OV20.

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36

Cilloniz, Cristian. "Role of the varicella zoster virus ORF9 protein in viral replication." 2007. http://proquest.umi.com/pqdweb?did=1331418241&sid=10&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (Ph.D.)--State University of New York at Buffalo, 2007.<br>Title from PDF title page (viewed on Nov. 27, 2007) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Ruyechan, William T. Includes bibliographical references.

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37

Huang, Yu-Yuan, and 黃俞淵. "Characterization of SARS-CoV encoded accessory proteins ORF8a and ORF8." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/74372663873642985655.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>97<br>SARS-CoV, a coronavirus, was identified as the etiologic agent for severe acute respiratory syndrome. It is established that human SARS-CoV originated from animals, such as palm civets and raccoon dogs. SARS-CoV genome shares about 99.8% homology with its animal counterpart. The major difference of the two viruses is the 29 nucleotide deletion found in the corresponding open reading frame (ORF) 8 of human SARS-CoV, given rise to ORF8a and ORF8b. Our previous data had shown that ORF8a localizes to mitochondria. Using yeast two-hybrid screening, ORF8a, but not OR

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Li, ChiWei, and 李誌偉. "A novel mechanism to regulate IS1550 putative transposase production by ORF1 protein." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/22403527173198471760.

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碩士<br>國立陽明大學<br>醫學生物技術研究所<br>90<br>We have previously identified a transposable element, IS1550 from Mycoplasma fermentans. This element encodes two open reading frames, ORF1 and ORF2. Two proteins were detected with the molecular weight of 16 kDa and 50 kDa, respectively, when expression of the IS1550 genes was examined in E. coli T7 expression system. The 16-kDa protein was determined to be encoded by ORF1, whereas the 50-kDa protein was produced by forming a fusion of ORF1 and ORF2, ORF12’, through an efficient —1 translational frameshift mechanism. Our previous studies have confirmed a fra

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39

Wu, Ting-Yun, and 吳亭昀. "Monoclonal Antibody Preparation and Cellular Distribution Analysis of Koi Herpesvirus ORF72 Protein." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8a7b5r.

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40

Ou, Chi-Ming, and 歐啟明. "Expression and Purification of the Major Envelope Protein of Orf Virus." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/50383988977441905067.

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碩士<br>中興大學<br>獸醫學系暨研究所<br>95<br>Abstract Orf is also known as contagious ecthyma, contagiou pustular dermatitis, Scabby mouth and sore mouth. Orf occurs worldwide in sheep and goats, especially in young animal. The disease is characterized by proliferative lesion on the lips, around the nostrils and in the oral mucosa. Orf virus is a member of the Parapoxvirus genus of Poxviridae. The virus particles are ovoid and the viral genome is a linear double-stranded DNA. The viral B2L gene encodes for the highly immunogenic major envelope protein , which is the homologue of vaccinia virus envelope pr

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LEE, Tzu-Ying, and 李姿穎. "Molecular Mechanism of the type I interferon antagonist function by SARS Coronavirus ORF6 protein." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/75653793395898183769.

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碩士<br>中國醫藥大學<br>醫學檢驗生物技術學系<br>96<br>Abstract Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease. The causative agent of SARS has been identified to be a new type of coronavirus, namely SARS coronavirus (SARS-CoV).SARS-CoV proteins including the ORF6 protein have been reported to inhibit interferon signaling response. The goal of this study is to identify human SARS-CoV ORF6-interacting proteins using the phage displayed human lung cDNA libraries and to investigate their interaction on the type I interferon antagonist function. At first, the recombinant ORF6 protein

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42

Chao, I.-Chi, and 趙譯棋. "Establishment of Recombinant Orf Virus Expressing Goatpox virus P32 Proteins." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/30630163851365322611.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>103<br>Orf virus (ORFV), belonging to parapoxvirus, causes skin lesions in infected sheep and goats. Due to the restricted host range, the skin tropism, the absence of systemic virus spread, and the short-lived ORFV vector-specific immunity allowing repeated immunizations, it has been successfully used as a novel viral vector system for expressing foreign antigens to prevent infectious diseases of swine, rabbit, and avian. Hence, study herein aimed to establish ORFV as a bivalent vaccine platform for goat. In 2008, goatpox (GP) outbreaks caused substantial loss

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43

Chorghade, Sandip Gulab. "Studies on Interactions between ARE Binding Proteins and Splicing Factors and their Role in Altered Splicing of PDGF-B ORF." Thesis, 2012. http://etd.iisc.ac.in/handle/2005/3227.

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Pre-mRNA splicing is an important level in posttranscriptional gene regulation that is essential for accurate protein synthesis and generating protein diversity. The abundance of cryptic splice sites and long intronic DNA sequences makes their splicing a complex one. The identification of correct exons and introns needs additional information in the form of splicing regulatory elements (SREs) along with canonical splice signals. The interplay among these SREs and the trans factors (which bind to SREs) gives the identity to introns and exons which in turn leads to precise pre-mRNA splicing. Pr

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Chorghade, Sandip Gulab. "Studies on Interactions between ARE Binding Proteins and Splicing Factors and their Role in Altered Splicing of PDGF-B ORF." Thesis, 2012. http://hdl.handle.net/2005/3227.

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Pre-mRNA splicing is an important level in posttranscriptional gene regulation that is essential for accurate protein synthesis and generating protein diversity. The abundance of cryptic splice sites and long intronic DNA sequences makes their splicing a complex one. The identification of correct exons and introns needs additional information in the form of splicing regulatory elements (SREs) along with canonical splice signals. The interplay among these SREs and the trans factors (which bind to SREs) gives the identity to introns and exons which in turn leads to precise pre-mRNA splicing. Pr

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Lin, Wei Li, and 林維莉. "Expression and functional analysis of the porcine circovirus type 2 Rep and ORF3 proteins." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/04865829915580224077.

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博士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>100<br>Porcine circovirus type 2 (PCV2) is a member belongs to the genus Circovirus of the Circoviridae family, and closely associated with a disease syndrome in pigs described as “postweaning multisystemic wasting syndrome” (PMWS) now known as porcine circovirus diseases (PCVD). The genome of PCV2 is a single-stranded circular DNA, and contains three major open reading frames (ORFs). They are ORF1, the rep gene, which encodes the Rep proteins responsible for virus replication; and ORF2, the cap gene, which encodes the immunogenic capsid (Cap) protein; and ORF3

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Starck, Holger [Verfasser]. "Das RNA-bindende Protein Orb2 und seine regulatorische Funktion in der Spermatogenese von Drosophila melanogaster / vorgelegt von Holger Starck." 2008. http://d-nb.info/988337436/34.

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Tanner, Tricia Lynn. "Analysis of the function of two varicella-zoster virus proteins involved in gene regulation IE63 and ORF29 /." 2007. http://proquest.umi.com/pqdweb?did=1240709031&sid=6&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (Ph.D.)--State University of New York at Buffalo, 2007.<br>Title from PDF title page (viewed on July 18, 2007) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Ruyechan, William T. Includes bibliographical references.

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Dan, Tran Quang, and 陳光瑩. "Studies on the Expression of Recombinant ORF3 Fusion Proteins of Porcine Circovirus Type 2 in Transgenic Tobacco." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/xwceag.

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碩士<br>中國文化大學<br>生物科技研究所<br>102<br>Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome in pigs and has impact on swine-producing industry worldwide. The open reading frame 3 (ORF3) of PCV2 which encodes an 11.9 kDa ORF3 protein has been found to be involved in the pathogenesis of PCV2 infection by its apoptotic activity. The ORF3–based antigens thus represent a traditional approach to develop efficacious oral vaccines for immunization against PCV2. In this study, various ORF3-containing expression vectors, namely pGKF/U-ORF3, pGKF/U-L-ORF3, pGK

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Lee, Chia-Chun, and 李佳俊. "Expression of modified ORF 5 protein of PRRSV in the baculovirus system and cell surface display system." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/pefp2t.

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Fabrizio, Jacqueline Alba. "Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH." Thesis, 2017. https://hdl.handle.net/2440/132758.

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Factor Inhibiting the Hypoxia Inducible Factor (FIH) is an oxygen-dependent asparaginyl hydroxylase that plays a role in the cellular response to changes in oxygen concentrations. It was first found to catalyse the post translational hydroxylation of a family of transcription factors known as Hypoxia Inducible Factors (HIFs), and thus acts as a cellular sensor of hypoxia. Subsequently, other protein substrates were discovered containing ankyrin (ANK) repeat domains, although their activities were not affected by hydroxylation. FIH null mice display a metabolic phenotype which is not obviously

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