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Dissertations / Theses on the topic 'Organic compounds Heterocyclic compounds'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Armugam, S. "Studies on N-Heterocyclic Compounds." Thesis, Indian Institute of Science, 1994. http://hdl.handle.net/2005/108.

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The thesis entitled "Studies on N-Hetero cyclic Compounds: (a) Reaction of 5,6,7,8-Tetrahydroisoquinolines with Vilsmeier Reagent and (b) Amide Induced in situ Alkylation of 5,6-Dihydroisoquinolines" is presented in two parts. Part I involves a study of the Vilsmeier reaction of 4-cyano-1,3-dihydroxy-5,6,7,8 tetrahydroisoquinoline derivatives, while Part II concerns the in situ alkylation of l-alkyl-4-cyano-3-methoxy-5,6- dihydroisoquinolines in presence of KNH2/liq.NH3.

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2

Crockett, Rowena. "Generation of free radicals from heterocyclic compounds." Thesis, University of Aberdeen, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290239.

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Tetrazolinones, thiatriazole 1-oxides and meso-ionic oxatriazoles were investigated as sources of free radicals. Mono-substituted tetrazolinones decomposed at their melting points. Nitrosation and nitration of the tetrazolinone ring was unsuccessful, although alkoxyalkylation of the ring took place in ether in the presence of nitrosomium and nitronium tetrafluoroborate. The tetrazolinone ring was photolytically unstable, and both eliminated nitrogen and cycloreverted. γ-irradiation of the naphthyl deivative caused cleavage of the nitrogen-hydrogen bond to give a radical which was identified by

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3

Lee, On-yi. "Synthesis of heterocycles via phenylseleno group transfer radical cyclization and chemoselective reductive amination promoted by InCl3." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B3955756X.

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4

Fallah, Asadollah. "Stereochemistry and reactivity of some 1,3-heterocyclic compounds." Thesis, University of Portsmouth, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328185.

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5

Berlin, Stefan. "Construction of Five-Membered Heterocyclic Compounds via Radical Cyclization." Doctoral thesis, Uppsala University, Department of Chemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3429.

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<p>This thesis describes how radical cyclization chemistry can be applied for the construction of heterocyclic compounds.</p><p>In the first part, a series of electron deficient α-phenylselenenylalkenes were prepared <i>via</i> a PhSeCl-addition/HCl-elimination sequence. Allyl- and propargylamines readily underwent conjugate addition to these species to produce pyrrolidines or dihydropyrrol derivatives, after triethylborane initiated reductive radical cyclization in the presence of tris(trimethylsilyl)silane.</p><p>The second part describes a convergent synthesis of the pineal hormone melatoni

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6

Shirtcliff, Laura Donnell. "'Coarctate' cyclizations : applications to heterocycle synthesis /." view abstract or download file of text, 2006. http://proquest.umi.com/pqdweb?did=1188876631&sid=1&Fmt=2&clientId=11238&RQT=309&VName=PQD.

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Thesis (Ph. D.)--University of Oregon, 2006.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 336-357). Also available for download via the World Wide Web; free to University of Oregon users.

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7

Hales, Ivan Daniel Cashman. "Flash vacuum pyrolysis of selected heterocyclic and unsaturated compounds." Thesis, London Metropolitan University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321720.

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8

Ho, Yee-Ping. "Some studies in nitrogen heterocyclic chemistry using Reissert compounds." Thesis, Loughborough University, 1986. https://dspace.lboro.ac.uk/2134/33250.

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The thesis reports the first examples of Reissert compounds prepared from five-membered ring heterocycles. The method utilises trimethylsilyl cyanide as the key reagent in a single phase non-aqueous medium. Previous attempts to synthesise such compounds have failed because, under the conventional two phase conditions, the reaction either does not proceed or ring opening of the heterocycle occurs. Reaction of benzothiazole with an acid chloride (aliphatic, aromatic or chloroformate) and trimethylsilyl cyanide in dichloromethane has been shown to give rise to 3-acyl-2-cyano-2,3-dihydrobenzothiaz

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9

Yuen, Yue Tai. "Trithiazyl trichloride in the synthesis of sulfur-nitrogen heterocyclic compounds." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362732.

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10

Roxburgh, C. J. "The synthesis of heterocyclic compounds from Indan-1, 3-diones." Thesis, University of Portsmouth, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234430.

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ABSTRACT 2-Phenyl-indan-1,3-dione reacts via a Michael addition with 2-vinylpyridine to yield 2-phenyl-2-(2-(2-pyridyl) ethyl) indan- 1,3-dione, which on catalytic hydrogenation of the pyridine ring yields, via a ring cyclization/expansion reaction, rel(12S,14aR) 12- phenyl-1~3,4,12,13,14,l4a-octahydropyrido[l,2-£] [2]benzazonin- 6,ll-dione. A lithium aluminium hydride reduction of rel(12S,14aR) 12- phenyl-l,2,3,4,12,l3,14,14a-octahydropyrido[l,2-£] [2]benzazonin- 6,ll-dione yielded rel(llS,12S,l4aR) ll-hydroxy l2-phenyl-substituted derivative as the only isomer~ Various derivatives of this sy

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11

Worakun, Tanachat. "Palladium and rhodium catalysed construction of carbocyclic and heterocyclic compounds." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317069.

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12

李安怡 and On-yi Lee. "Synthesis of heterocycles via phenylseleno group transfer radical cyclization and chemoselective reductive amination promoted by InCl3." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3955756X.

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13

Chowdhury, M. L. A. "Oxidation of peptides : synthesis of heterocyclic compounds related to the penicillins." Thesis, Oxford Brookes University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370498.

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14

Sokmen, Munevver. "Studies of the metal ion-catalysed oxidation of heterocyclic sulfur compounds." Thesis, Sheffield Hallam University, 1997. http://shura.shu.ac.uk/20384/.

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Chemical oxidation by hydrogen peroxide is used for the treatment of hazardous organic materials present at low concentrations in contaminated soil and water. A knowledge of the oxidation of thiophene and its derivatives, with particular reference to oxidative destruction and the identification of intermediate oxidation products would be useful for a deeper understanding of reaction mechanisms in waste treatment and the optimization of conditions. In this thesis, the oxidation of thiophenes, namely thiophene and 2- and 3-methylthiophene, with hydrogen peroxide and catalyst systems, e.g. Fenton

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15

McErlean, Christopher Stephen Paschal. "Synthesis and biosynthesis of some naturally occuring oxygen heterocycles /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17082.pdf.

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16

Ramaite, Ipfani David Isaiah. "Synthetic and physical organic studies of chromone derivatives." Thesis, Rhodes University, 1997. http://hdl.handle.net/10962/d1005045.

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A range of chromone-2-carboxylic acids has been prepared by condensing suitably substituted 2-hydroxyacetophenones with diethyl oxalate. pK₂ Studies of these acids revealed that 6- or 7-methoxy substituents decreased acidity while the 6-nitro group enhanced acidity; the strongest acid was the 3-chloro derivative, the increase in acidity being attributed to steric inhibition of acid-weakening delocalisation between the carboxyl group and the chromone system. Various chromone-2-carboxamides, derived from acid chloride precursors, were converted to polysubstituted acrylamides by nucleophilic ring

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17

Lombard, M. J. "Aspects of the use of N-O heterocyclic compounds in organic synthesis." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370281.

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18

Creeke, Paul Ivan. "Electrophilic additions to functionalised alkenes : the chemistry and synthesis of heterocyclic compounds." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.255650.

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19

陳淑妤 and Suk-yu Florence Chan. "Novel synthesis and chemistry of 1, 4, 2-dithiazolium salts." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1988. http://hub.hku.hk/bib/B30426352.

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20

Kleinhans, Dewald Johannes. "Studies in the synthesis of benzoxazole compounds." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97900.

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Thesis (PhD)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Benzoxazoles are an important class of π-electron-excessive, benzene-fused heterocyclic compounds found in natural products and display a wide range of pharmacological applications. It is therefore a widely used starting scaffold for drug and agrochemical discovery programs. Other applications include: chiral auxiliaries in asymmetric reactions, chiral receptors for the resolution of racemic mixtures, fluorescent whitening dyes, various photochromic materials and as ligands for a wide range of catalytic reactions. Due to ou

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21

Simpson, Bryan Garth. "Reactions of heterocycles with phosphorus compounds." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329647.

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22

Ducept, Pascal. "Synthesis of heterocycles using silyldiazocarbonyl compounds." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271307.

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23

Abedelrasoul, Abuelgasim Abbaker. "Studies on the chemistry of some sulphides and of some sulphur-containing heterocyclic compounds." Thesis, University of Hull, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333763.

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24

Wang, Ming De. "Metal catalyzed ring expansion carbonylation, rearrangement, cyclization and oxidation reactions of nitrogen containing heterocyclic compounds." Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/6851.

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An important class of carbonylation reactions to construct lactams are those that involve the direct "stitching" of carbon monoxide into a nitrogen heterocycle resulting in ring expansion. Cobalt carbonyl catalyzed the carbonylation of a series of 2-substituted pyrrolidines to form piperidinones. The reaction is regiospecific in most cases and the yield of product is increased when ruthenium carbonyl is present as a second catalyst. Chapter 2 of this thesis describes this piece of work. During the investigation of the ring expansion carbonylation reactions of pyrrolidines, a new rearrangement

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25

Rogers, Bruce. "Approaches to cyclobutane containing cage compounds." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299584.

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26

Brown, S. M. "The chemistry and conformational analysis of some normal and medium ring alicyclic and heterocyclic compounds." Thesis, University of Huddersfield, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354322.

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27

Lizano, Gispert Enric. "Design and synthesis of heterocyclic compounds potentially antitumor by enzymatic inhibition." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671158.

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This doctoral thesis is focused on the investigation and development of new compounds directed to different cancer and tropical diseases targets. Drug resistance, as well in cancer as in tropical diseases, is a hurdle which in the latest years it is driving the scientific community to investigate in new diagnostic techniques, to improve in genomic sequencing, as well as to develop new treatments through the synthesis of new small molecules, for example. The physiologic framework, that drives to resistance, is complex and for this reason, personalized treatments is an increasing concept and ne

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28

Sriramulu, Phenahas Gandu. "On-Metal Synthesis of Some Aryl Substituted Rhenium &#951⁵ Cyclopenta[C] Pyridazyl Complexes." TopSCHOLAR®, 2010. http://digitalcommons.wku.edu/theses/197.

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Heterocyclic organic and organometallic compounds (e.g. polypyrrole) and their derivatives have been of great interest for conductive polymers due to their novel properties and environmental stability as compared to non-aromatic analogs (e.g. polyacetylene). We are interested in synthesizing organometallic pyridazines and rhenium pyridazyl complexes for polymer research. SeveraI5,6-fused ring pyridazines (1,2-CsH3(CRNH)(CRN) have been synthesized and characterized. Additionally, pyridazyl complexes of rhenium were synthesized in three steps beginning from fulvenes 1,2-CsH3(COHR)(COR). On-Metal

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29

Shah, Sana. "Synthesis and Characterization of Manganese Pyridazyl Complexes." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1298.

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Heterocyclic’s and their fused-ring derivatives have been of interest for their use in electronic materials due to their ease of production, synthetic versatility, and low cost compared to traditional inorganic materials like silicon. Pyridazines have been found to be useful in catalysis gas storage, polymeric sensors and biological mimetics. When a transition-metal is fused into a synthesized pyridazine, unique properties such as conductivity and optics are allowed. In this work, synthesized pyridazine complexes will be analyzed by mass spectroscopy, elemental analysis, nuclear magnetic reson

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30

Delsorbo, Carter A., Annie B. McCullough, Pau Peiro'Vila, et al. "Ruthenium Compounds for Photodynamic Chemotherapeutics and Solar Fuel Generation." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/156.

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Ruthenium polypyridyl complexes have long been studied due to their unique photophysical characteristics and their synthetic accessibility. We report here the use of new ruthenium polypyridyl’s in photodynamic chemotherapeutic and solar fuel applications. Nearly half of all chemotherapeutics administered today are derived from platinum-based drugs (platins) which lack specificity and can cause sever side-effects. Photodynamic chemotherapeutics (PDT) circumvent these issues utilizing light activation at the site of cancerous cells to generate a cytotoxic Ru(II) center and eventually trigger cel

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31

Shan, Jingning. "Synthesis of organic and inorganic compounds for OLED application: Physico-chemical characterization of new diamines, heterocycles and group 13 compounds." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/29163.

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This thesis is focused on the synthesis and characterization of organic and inorganic electroluminescent materials for organic light-emitting diodes (OLED). The synthetic work was aimed at several of the key components of multilayer OLEDs and followed the latest developments in this area. Three types of OLED materials, namely hole-transport (HT), electron-transport (ET) and emission (EM) materials in four groups were successfully synthesized. The characterization of these materials focuses on the physical and chemical features that are important in defining performance parameters. This chemist

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32

Yue, Congyong. "Palladium complexes of aromatic amide-derived phosphines and application for synthesis of biaryls, nitrogen heterocycles, and benzo[b]furans /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202009%20YUE.

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33

Hassan, Mohammad Rokib, and University of Lethbridge Faculty of Arts and Science. "Self-assembled molecular rods and squares with chalcogenadiazole framework ligands." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, c2010, 2010. http://hdl.handle.net/10133/2639.

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During the attempts to carry out Suzuki coupling reactions, the σ-bonded Pd−Caryl benzochalcogenadiazolyl complexes trans-[ClPd(PPh3)2(C6H2BrN2E)] (E = S, Se) were isolated. The corresponding bromo derivatives were also synthesized on purpose to investigate their activity in Stille coupling reactions. A head-to-tail dimer trans- [{ClPd(PPh3)(μ-C6H2BrN2Se)}2] was synthesized from the thermolysis of trans- [ClPd(PPh3)2(C6H2BrN2Se)] in the presence of SeO2. The reduction potentials of the mononuclear and dinuclear complexes were measured by cyclic voltammetry (CV) and square wave voltammetry (SWV

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34

Jalali, Elnaz. "Regiospecific P-Bromination of Activated Aromatic Systems – Greener Approach." TopSCHOLAR®, 2017. http://digitalcommons.wku.edu/theses/1950.

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The halogenated derivatives of heterocyclic compounds (haloarenes) are highly utilized in many fields of chemistry, including drug discovery, medicinal, and material chemistry. There are a variety of ways to functionalize an aromatic system and introduce halogen substituent into the ring. However, electrophilic aromatic substitution (EAS) has been the focus of growing attention, particularly for electronrich substrates. Electrophilic aromatic bromination protocols are one of the most important electrophilic aromatic substitution reactions. However, preparation of bromoarenes classically recomm

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35

Rhee, Jong Uk. "Part I. Synthesis of n-heterocyclic furanosides and pyranosides via 5- or 6-exo-trig-radical cyclization. Part II. (a) Palladium catalyzed silystannylative cyclization of diynes and allenynes. (b) Regioselective Diels-Alder reaction of vinylsilane and its application to Papulacandin D core structure." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1078850581.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xx, 456 p.; also includes graphics Includes bibliographical references (p. 449-456). Available online via OhioLINK's ETD Center

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36

Tatton, Matthew R. "New methods for the synthesis of aromatic compounds." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:52a95189-d8ea-432f-aefd-4f9ae7ef996a.

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<strong>Introduction</strong> The introduction describes the importance of arylamine compounds to society and provides a brief overview of the methods available for their synthesis. The application of metathesis catalysis to the de novo synthesis of heteroaromatic compounds is also described. <strong>Results and discussion</strong> The first section describes efforts towards the de novo synthesis of arylamines using a cross metathesis/oxidation protocol to form a 1,5-unsaturated dicarbonyl followed by an amine mediated cyclisation. The scope with respect to the 1,5-unsaturated dicarbonyl and a

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37

Fischer, Kristapher Edward, and University of Lethbridge Faculty of Arts and Science. "Synthesis and characterization of novel cyclophanes from 5,5'-bi(isobenzofuran)." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005, 2005. http://hdl.handle.net/10133/255.

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Isobenzofuran has since its discovery proven an important intermediate in the synthesis of novel organic compounds, due to its high reactivity in Diels-Alder reactions. This thesis details the synthesis, purification and characterization of cyclophane compounds derived from a novel analogue of isobenzofuran, 5,5'-bi(isobenzofuran). Because of the relative rarity of molecules containing multiple isobenzofuran units, 5.5'-bi(isobenzofuran) is an excellent candidate for study. Prelminary analysis of an additional novel analogue of isobenzofuran, 5.5'-bis(isobenzofuranyl) acetylene, is also presen

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38

Mortimer, Claire. "New transformations of azacycles." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:1fe27dc8-6525-4d45-a398-b3e6531e7b99.

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The work presented in this thesis involves new transformations of azacycles, focusing on the introduction of functionality α-to N. α-C-H functionalisation on an azetidine has been a long-standing challenge, with N-protecting/activating groups that work well in the higher and lower azacyclic systems not viable. A recent breakthrough in the Hodgson group showed the rarely used N-thiopivaloyl group was effective for α-deprotonationâ electrophile trapping on azetidines, but was not without limitations concerning harsh removal conditions and scope for further substitutions. This

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39

Di, Pietro Ornella. "Exploring heterocyclic scaffolds in the development of multi-target anti-Alzheimer and multi-trypanosomatid compounds." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/318585.

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The aim of this PhD thesis consists of the synergistic combination of both highly efficient synthetic approaches and molecular modelling tools for the structure-based drug design and synthesis of novel bioactive heterocyclic compounds. The work carried out has followed two main research lines, namely the development of novel disease-modifying anti-Alzheimer agents and still unexplored chemical entities for the treatment of Neglected Tropical Diseases (NTDs). The results obtained have been presented as a compendium of publications and draft manuscripts. In the framework of the anti-Alzheimer re

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40

Morawa, Eblagon Katarzyna Anna. "On the recyclability of liquid organic hydrides : hydrogenation of 9-ethylcarbazole and other heterocyclic compounds for application in hydrogen storage." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:eca70cd1-68cb-48c2-b505-852b11876774.

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The main focus of the present work is the recovery process for spent fuels based on catalytic hydrogenation of liquid organic hydrides (LOH). To gain the knowledge about the possible hurdles of hydrogen loading process, the hydrogenation of 9-ethylcarbazole as a model compound was elected to be studied in more detail. The structures of the intermediates and products of this reaction were characterized for the first time using combined GC-MS and NMR analysis with reference to DFT calculations. The fully saturated product was found to be a mixture of stereoisomers. A reaction model was developed

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Larksarp, Chitchamai. "Palladium-catalyzed cycloaddition reaction of 2-vinyloxiranes, 2-vinyloxetanes, o-iodophenols and o-iodoanilines with heterocumulenes, the efficient methods for the preparation of heterocyclic compounds." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0021/NQ57052.pdf.

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42

Campbell, Craig D. "Lewis base-promoted organocatalysis : O- to C-carboxyl transfer reactions." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/2609.

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This work describes the application of a variety of Lewis bases, encompassing predominantly N-heterocyclic carbenes (NHCs), but also the use of imidazoles, aminopyridines, amidines and isothioureas, as effective catalysts in the dearomatisation of heterocyclic carbonates, predominantly the rearrangement of oxazolyl carbonates to their C-carboxyazlactone isomers by means of the Steglich rearrangement. This rearrangement reaction has been investigated extensively, with the development of simplified reaction procedures and the invention of domino cascade protocols incorporating this transformatio

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43

Diac, Andreea Petronela. "Design, synthesis and supramolecular architectures of new heterocyclic compounds with potential applications in material chemistry and photovoltaic conversion." Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0019/document.

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La thèse intitulée «Design, Synthesis and SupramolecularArchitectures of New Heterocyclic Compounds with PotentialApplications in Material Chemistry and Photovoltaic Conversion” eststructurée en cinq chapitres traitant de nouveaux: a)cyclopenta[c]pyrannes hétérocyclique; b)des propriétés fluorescentes; d) potentiels dispositifs de l'électroniquemoléculaire; d) donneurs moléculaires pour les photovoltaïquesorganiques et e) carbon‘quantum’dots électroluminescents.Le premier chapitre présente une étude des dérivéspseudoazulenique ayant une unité cyclopenta[porte sur leur synthèse, l'analyse struc

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44

Byrichetti, Kiranmai. "Synthesis and Structure of a Substituted Pyridazine." TopSCHOLAR®, 2011. http://digitalcommons.wku.edu/theses/1080.

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Pyridazines are heterocyclic compounds with an N-N bond in their ring structure. Heterocyclic aromatic compounds are of great interest as a result of their novel properties and commercial applications. Our current research is focused on the potential role of pyridazines in next generation electronic devices that utilize organics as the semiconducting material. The synthesis of 5, 6-fused ring pyridazines beginning from fulvenes (Scheme 1) is described herein. These fused heterocycles will serve as synthetic models and building blocks for potential organic or organometallic conducting polymers.

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45

Arnaout, Abdulkarim al. "Synthese regioselective de dihydropyridines et de pyridines 2- ou 4-fonctionnalisees : applications." Poitiers, 1987. http://www.theses.fr/1987POIT2254.

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46

Sherwood, Alexander M. "Design, Synthesis and Biological Evaluation of Novel Compounds with CNS-Activity Targeting Cannabinoid and Biogenic Amine Receptors." ScholarWorks@UNO, 2014. http://scholarworks.uno.edu/td/1831.

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This work seeks to contribute to the discipline of neuropharmacology by way of structure activity relationship from the standpoint of an organic chemist. More specifically, we sought to develop robust synthetic methodology able to efficiently produce an array of compounds for the purpose of systematic evaluation of their interaction with specific sights within the central nervous system (CNS) in order to better understand the mind and to develop drugs that may have beneficial effects on neurological function. The focus of these studies has been toward the development of novel molecules, using

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47

Collett, Christopher J. "Mechanistic studies of azolium ions and their role in organocatalysis." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/3868.

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This thesis describes our physical organic and mechanistic investigations into N Heterocyclic Carbene (NHC) mediated organocatalytic transformations, through a collaboration with the research group of Dr AnnMarie O'Donoghue and PhD student Richard Massey at Durham University. Initial research focused upon the determination of kinetic acidities and associated pKₐ values for a range of triazolium salts using C(3) H/D exchange, monitored by ¹H NMR spectroscopy. Estimates for pKₐ values in the range 16.6 17.4 were obtained, which are some ~2 and ~3 5 pK units lower than analogous imidazolium and t

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Kulkarni, Abhishek S. "Design, Synthesis and Pharmacological Characterization of Potential Mu Opioid Receptor Selective Ligands." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5787.

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Selective Mu Opioid Receptor (MOR) antagonists possess immense potential in the treatment of opioid abuse/addiction. Utilizing the “message-address” concept, our laboratory reported a novel, reversible, non-peptide MOR selective antagonist 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4՛-pyridyl)carboxamido]morphinan (NAP). Molecular modeling studies revealed that the selectivity of NAP for the MOR is because of a π-π stacking interaction of its pyridine ring with the Trp318residue in theMOR. Pharmacological characterization showed that NAP is a P-glycoprotein substrate, thereby limitin

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San, Juan Ocete Alexis. "Nuevos materiales macromoleculares formados por la unión de moléculas con estado birradical triplete asequible térmicamente." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/587192.

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Estudios previos de nuestro grupo de investigación describieron moléculas orgánicas heterocíclicas, aparentemente de capas cerradas que presentan carácter birradical triplete asequible térmicamente. La formación de esta especie birradicalaria proviene de la rotura de un doble enlace exocíclico por rotación de dicho enlace. Un factor de estabilización del biradical formado es la conjugación de uno de los electrones desapareados con un ciclo aromático aceptor de electrones y el otro con otro ciclo dador de electrones, con la consiguiente deslocalización de los mismos, de manera independiente, e

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Argade, Malaika. "Galantamine's Deconstruction in the Quest of a PAM Pharmacophore." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5461.

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Alzheimer’s disease is a progressive neurodegenerative disorder generally affecting people above the age of 65 years. Even though the pathophysiological hallmarks of AD were established more than a hundred years ago, there is yet to be a drug that can stop its characteristic neuronal damage. Of the five currently FDA-approved drugs, galantamine has a unique mechanism of action. Apart from being an AChE inhibitor, galantamine can effectively potentiate (positive allosteric modulator) the effect of agonists at nAChRs at concentrations lower than those required for its action as an AChE inhibitor

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