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Journal articles on the topic 'Organic hydrazide'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Gera, Ankur, Chander Mohan, and Sandeep Arora. "Synthesis of Phthaloylglycyl Hydrazide Derivatives: Selective Protection of Phthalimide Group from Hydrazinolysis." Current Organic Synthesis 15, no. 6 (2018): 839–45. http://dx.doi.org/10.2174/1570179415666180601083256.

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Background: N-phthalimide amino acid hydrazide is a class of compounds that have the potential therapeutic use. In general, hydrazinolysis of N-substituted amino acid(s) ester removes the ester group and yields the corresponding hydrazide. However, in case if N-substitution group is phthalimide, phthalimide group is cleaved and not the ester group. The resulted compound, therefore, is amino acid ester rather than Nphthalimide amino acid hydrazide. The above class of compounds, because of susceptibility of phthalimide group to hydrazinolysis, has previously been synthesized by a lengthy three-s

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2

Wu, Shouting, Xi Liang, Fang Luo, et al. "Synthesis, Crystal Structure and Bioactivity of Phenazine-1-carboxylic Acylhydrazone Derivatives." Molecules 26, no. 17 (2021): 5320. http://dx.doi.org/10.3390/molecules26175320.

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A phenazine-1-carboxylic acid intermediate was synthesized from the reaction of aniline and 2-bromo-3-nitro-benzoic acid. It was then esterified and reacted with hydrazine hydrate to afford phenazine-1-carboxylic hydrazine. Finally, 10 new hydrazone compounds 3a–3j were obtained by the condensation reaction of phenazine-1-carboxylic acid hydrazide and the respective aldehyde-containing compound. The structures were characterized by 1H and 13C NMR spectroscopy, MS and single crystal X-ray diffraction. The antitumor activity of the target compounds in vitro (HeLa and A549) was determined by thia

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3

Zhang, Xiaolai. "Oxidations of Benzhydrazide and Phenylacetic Hydrazide by Hexachloroiridate(IV): Reaction Mechanism and Structure–Reactivity Relationship." Molecules 25, no. 2 (2020): 308. http://dx.doi.org/10.3390/molecules25020308.

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Benz(o)hydrazide (BH) is the basic aryl hydrazide; aryl hydrazides have been pursued in the course of drug discovery. Oxidations of BH and phenylacetic hydrazide (PAH) by hexachloroiridate(IV) ([IrCl6]2−) were investigated by use of stopped-flow spectral, rapid spectral scan, RP-HPLC and NMR spectroscopic techniques. The oxidation reactions followed well-defined second-order kinetics and the observed second-order rate constant k′ versus pH profiles were established over a wide pH range. Product analysis revealed that BH and PAH were cleanly oxidized to benzoic acid and phenylacetic acid, respe

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4

Johnson, Andrew L., Nathan Hollingsworth, Andrew Kingsley, Gabriele Kociok-Köhn, and Kieran C. Molloy. "Organocadmium Hydrazide and Hydrazine Complexes." Organometallics 28, no. 8 (2009): 2650–53. http://dx.doi.org/10.1021/om900121z.

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5

Yehye, Wageeh, and Amit Nath. "Acid Hydrazide: A Potential Reagent for the Synthesis of Semicarbazones." Synthesis 50, no. 21 (2018): 4301–12. http://dx.doi.org/10.1055/s-0037-1609557.

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Complex semicarbazone derivatives were successfully synthesized from substituted semicarbazides in acidic ethanol upon heating in the presence of aldehyde. The reaction is functional group tolerant and chemoselective because no terminal hydrazine moiety is present in the substituted semicarbazides. Thus, functional groups such as esters and acetyls, which are prone to reaction with hydrazine, can also be used in this reaction because the terminal hydrazine moiety of the acid hydrazide was protected by aryl isocyanates in order to prepare substituted semicarbazides. In addition, neither of the

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6

Chauhan, Pradeep S., Skye Brettell, Mulamreddy Ramakotaiah, et al. "Hydrazine derivative synthesis by trifluoroacetyl hydrazide alkylation." Canadian Journal of Chemistry 98, no. 9 (2020): 485–94. http://dx.doi.org/10.1139/cjc-2020-0052.

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N′-Alkyl hydrazides were effectively synthesized by routes featuring installation, alkylation, and removal of a trifluoroacetyl group. A set of amino acid derived hydrazides were acylated using trifluoroacetic anhydride, and the resulting trifluoroacetyl hydrazides were alkylated with alcohols in Mitsunobu reactions and with alkyl halides under alkaline conditions. Removal of the trifluoroacetyl group was affected under reductive and hydrolytic conditions to provide the respective N′-alkyl hydrazides. This three-step process may be performed without isolation of intermediates to yield N′-alkyl

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7

Tokumaru, Kazuyuki, Kalisankar Bera, and Jeffrey Johnston. "1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis Using Diverted Umpolung Amide Synthesis." Synthesis 49, no. 20 (2017): 4670–75. http://dx.doi.org/10.1055/s-0036-1590802.

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Umpolung Amide Synthesis (UmAS) has emerged as a superior alternative to conventional amide synthesis methods based on carbonyl electrophiles in a range of situations, particularly when epimerization-prone couplings are prescribed. In an unanticipated development during our most recent studies, we discovered that diacyl hydrazide products from UmAS were not formed as intermediates when using an acyl hydrazide as the amine acceptor. This resulted in a new preparation of 1,3,4-oxadiazoles from α-bromonitroalkane donors. We hypothesized that a key tetrahedral intermediate in UmAS was diverted tow

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8

Suzuki, Ichiro, Ai Hirata та Kei Takeda. "Development of Cyclic Hydrazine and Hydrazide Type Organocatalyst ⎯ Mechanistic Aspects of Cyclic Hydrazine/Hydrazide-Catalyzed Diels-Αlder Reactions". HETEROCYCLES 79, № 1 (2009): 851. http://dx.doi.org/10.3987/com-08-s(d)54.

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9

Love, Dillon, Kangmin Kim, Dylan W. Domaille та ін. "Catalyst-free, aza-Michael polymerization of hydrazides: polymerizability, kinetics, and mechanistic origin of an α-effect". Polymer Chemistry 10, № 42 (2019): 5790–804. http://dx.doi.org/10.1039/c9py01199d.

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10

Shabeeb, Ihsan, Luay Al-Essa, Majed Shtaiwi, et al. "New Hydrazide-hydrazone Derivatives of Quinoline 3-Carboxylic Acid Hydrazide: Synthesis, Theoretical Modeling and Antibacterial Evaluation." Letters in Organic Chemistry 16, no. 5 (2019): 430–36. http://dx.doi.org/10.2174/1570178616666181227122326.

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A series of biologically active 3-quinoline carboxylic acid hydrazide-hydrazones has been synthesized from 3-quinoline carboxylic acid hydrazide and a variety of aldehydes, with moderate to good yields. The chemical structures of the new products were confirmed by elemental analysis, IR, and 1H NMR, 13C NMR spectral data. The structural and frontier molecular orbital (FMO) properties and the density functional theory (DFT) calculations were conducted for the new compounds. The new hydrazide-hydrazones exhibited low to moderate antibacterial activity against Staphylococcus aureus and Esherichia

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11

Josephrajan, T., and V. T. Ramakrishnan. "Thermal and microwave assisted synthesis of N-aroylamino acridinediones." Canadian Journal of Chemistry 85, no. 9 (2007): 572–75. http://dx.doi.org/10.1139/v07-075.

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A series of N-aroylamino acridinediones (3a–3d and6a–6e) have been synthesized from tetraketones (1 and 4) and benzoic hydrazides (2a–2d and 5a–5e) under thermal and microwave irradiation conditions with solid supports.Key words: acridine, hydrazide, microwave irradiation.

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12

Timperio, Anna Maria, Sara Rinalducci, and Lello Zolla. "Hydrazide derivatives produce active oxygen species as hydrazine." Bioorganic Chemistry 33, no. 6 (2005): 459–69. http://dx.doi.org/10.1016/j.bioorg.2005.09.001.

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13

Popiołek, Łukasz. "Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones." International Journal of Molecular Sciences 22, no. 17 (2021): 9389. http://dx.doi.org/10.3390/ijms22179389.

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Hydrazide–hydrazones possess a wide spectrum of bioactivity, including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antidepressant, antiviral, and antiprotozoal properties. This review is focused on the latest scientific reports regarding antibacterial, antimycobacterial, and antifungal activities of hydrazide–hydrazones published between 2017 and 2021. The molecules and their chemical structures presented in this article are the most active derivatives, with discussed activities having a hydrazide–hydrazone moiety as the main scaffold or as a side

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14

Patel, G. R., J. J. Maru, and Rakesh Yadav. "Antimicrobial Screening of Synthesized some Novel Azomethines via Organic Base." International Letters of Chemistry, Physics and Astronomy 43 (January 2015): 26–33. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.43.26.

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The author has synthesized azomethines in which carbonyl group is replaced by amine of acid hydrazides. The intermediates were prepared by using 2-mercapto benzimidazole with N-(4-Acetyl-phenyl)-2-chloro-acetamide in the presence of K2CO3. The Resulted product was further treated with different substituted of acid hydrazide in ethanol to yield the titled compounds using a catalytic amount of acetic acid. New products were examined for their antibacterial effects against Gram-positive and Gram-negative strains and antifungal were highly potent with lowest MIC Values. The structural assignments

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15

Morpurgo, L., O. Befani, S. Sabatini, et al. "Spectroscopic studies of the reaction between bovine serum amine oxidase (copper-containing) and some hydrazides and hydrazines." Biochemical Journal 256, no. 2 (1988): 565–70. http://dx.doi.org/10.1042/bj2560565.

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The carbonyl cofactor of bovine serum amine oxidase, recently identified as pyrroloquinoline quinone [Ameyama, Hayashi, Matsushita, Shinagawa & Adachi (1984) Agric. Biol. Chem. 48, 561-565; Lobenstein-Verbeek, Jongejan, Frank & Duine (1984) FEBS Lett. 170, 305-309], reacts stoichiometrically and irreversibly with hydrazides of phenylacetic acid and of benzoic acid. With the phenylacetic hydrazides a reversible intermediate step was detected by competition with substrate, carbonylic reagents or phenylhydrazine, a typical inhibitor of the enzyme. All hydrazides form an intense broad band

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16

Wang, Wei Wei, Zhong Xiao Li, Yu Guang Feng, and Jun Jie Gong. "Preparation of an In Situ Crosslinked Polymer Coating and a Double-Layered Thermal CTP Plate." Advanced Materials Research 781-784 (September 2013): 458–62. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.458.

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The research relates to a method for preparing an in-situ crosslinked polymer coating. It has excellent solubility in aqueous alkaline solution, but didnt dissolve in general organic solvents and water. The crosslinked polymer coating was made through the reaction of a copolymer derived from diacetone acrylamide (DAAM) and ethacryloyloxyethyl-carbazochrome-p-toluenesulfonamide (MCTS) with a crosslinking agent, isonicotinyl hydrazide. The two components were dissolved in 3-methoxypropanol to prepare the coating solution, which was then coated to a grained and anodized aluminum substrate and dri

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17

Silva-Caldeira, Priscila Pereira, Antônio Carlos Almendagna de Oliveira Junior, and Elene Cristina Pereira-Maia. "Photocytotoxic Activity of Ruthenium(II) Complexes with Phenanthroline-Hydrazone Ligands." Molecules 26, no. 7 (2021): 2084. http://dx.doi.org/10.3390/molecules26072084.

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This paper reports on the synthesis and characterization of two new polypyridyl-hydrazone Schiff bases, (E)-N′-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)thiophene-2-carbohydrazide (L1) and (E)-N′-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)furan-2-carbohydrazide (L2), and their two Ru(II) complexes of the general formula [RuCl(DMSO)(phen)(Ln)](PF6). Considering that hydrazides are a structural part of severa l drugs and metal complexes containing phenanthroline derivatives are known to interact with DNA and to exhibit antitumor activity, more potent anticancer agents can be obtained by covalently li

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18

Garifullin, Bulat F., Olga V. Andreeva, Irina Yu Strobykina, Vasiliy M. Babaev, and Vladimir E. Kataev. "Macrocyclic Derivatives of Diterpenoid Isosteviol with Hydrazide and Hydrazone Moieties." Macroheterocycles 6, no. 2 (2013): 184–91. http://dx.doi.org/10.6060/mhc130334k.

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19

Youssef, A. SA, M. I. Marzouk, H. MF Madkour, A. MA El-Soll, and M. A. El-Hashash. "Synthesis of some heterocyclic systems of anticipated biological activities via 6-aryl-4-pyrazol-1-yl-pyridazin-3-one." Canadian Journal of Chemistry 83, no. 3 (2005): 251–59. http://dx.doi.org/10.1139/v05-045.

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6-Aryl-4-pyrazol-1-yl-pyridazin-3-one (1) reacted with a PCl5POCl3 mixture to give the 3-chloropyridazine derivative 3. Reaction of 3 with 2-hydroxybenzoylhydrazide and semicarbazide hydrochloride afforded 4 and 5. Reaction of 1 with ethyl chloroacetate gave 8. Reaction of 8 with hydrazine hydrate yielded the hydrazide 9. The hydrazide 9 condensed with the acetylenic ketones and esters 10a10d and acetylacetone to give the adducts 11a, 11b, 12, 13, and 14. Reacting 1 with formaldehyde and piperidine, morpholine, or piperazine, 3-bromopropanoic acid, acetic anhydride, p-toluenesulphonyl chlori

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20

Nasr, Tamer, Samir Bondock, and Mahmoud Youns. "Anticancer activity of new coumarin substituted hydrazide–hydrazone derivatives." European Journal of Medicinal Chemistry 76 (April 2014): 539–48. http://dx.doi.org/10.1016/j.ejmech.2014.02.026.

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21

Šedová, Petra, Radovan Buffa, Peter Šilhár, et al. "The effect of hydrazide linkers on hyaluronan hydrazone hydrogels." Carbohydrate Polymers 216 (July 2019): 63–71. http://dx.doi.org/10.1016/j.carbpol.2019.04.011.

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22

Tian, Xiaobo, Jie Li, and Wei Huang. "Optimal peptide hydrazide ligation with C-terminus Asp, Asn, and Gln hydrazides." Tetrahedron Letters 57, no. 38 (2016): 4264–67. http://dx.doi.org/10.1016/j.tetlet.2016.07.101.

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23

Bordei Telehoiu, Alexandra T., Diana C. Nuță, Miron T. Căproiu, et al. "Design, Synthesis and In Vitro Characterization of Novel Antimicrobial Agents Based on 6-Chloro-9H-carbazol Derivatives and 1,3,4-Oxadiazole Scaffolds." Molecules 25, no. 2 (2020): 266. http://dx.doi.org/10.3390/molecules25020266.

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In this paper, we aimed to exploit and combine in the same molecule the carbazole and the 1,3,4-oxadiazole pharmacophores, to obtain novel carprofen derivatives, by using two synthesis pathways. For the first route, the following steps have been followed: (i) (RS)-2-(6-chloro-9H-carbazol-2-yl)propanonic acid (carprofen) treatment with methanol, yielding methyl (RS)-2-(6-chloro-9H-carbazol-2-yl)propanoate; (ii) the resulted methylic ester was converted to (RS)-2-(6-chloro-9H-carbazol-2-yl)propane hydrazide (carprofen hydrazide) by treatment with hydrazine hydrate; (iii) reaction of the hydrazid

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24

Chelushkin, Pavel S., Ksenia V. Polyanichko, Maria V. Leko, Marina Yu Dorosh, Thomas Bruckdorfer, and Sergey V. Burov. "Convenient method of peptide hydrazide synthesis using a new hydrazone resin." Tetrahedron Letters 56, no. 4 (2015): 619–22. http://dx.doi.org/10.1016/j.tetlet.2014.12.056.

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25

Lemay, Mathieu, Livia Aumand, and William W Ogilvie. "Design of a Conformationally Rigid Hydrazide Organic Catalyst." Advanced Synthesis & Catalysis 349, no. 3 (2007): 441–47. http://dx.doi.org/10.1002/adsc.200600268.

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26

Ikizler, A. Aykut, Aysun Lkizler, and Neslihan Uzunismail. "A STUDY ON CYANOACETIC ACID HYDRAZIDE." Organic Preparations and Procedures International 24, no. 3 (1992): 365–68. http://dx.doi.org/10.1080/00304949209355905.

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27

Krátký, Martin, Katarína Svrčková, Quynh Anh Vu, Šárka Štěpánková, and Jarmila Vinšová. "Hydrazones of 4-(Trifluoromethyl)benzohydrazide as New Inhibitors of Acetyl- and Butyrylcholinesterase." Molecules 26, no. 4 (2021): 989. http://dx.doi.org/10.3390/molecules26040989.

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Based on the broad spectrum of biological activity of hydrazide–hydrazones, trifluoromethyl compounds, and clinical usage of cholinesterase inhibitors, we investigated hydrazones obtained from 4-(trifluoromethyl)benzohydrazide and various benzaldehydes or aliphatic ketones as potential inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). They were evaluated using Ellman’s spectrophotometric method. The hydrazide–hydrazones produced a dual inhibition of both cholinesterase enzymes with IC50 values of 46.8–137.7 µM and 19.1–881.1 µM for AChE and BuChE, respectively. The m

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28

Morsi, Rania E., Moataz Elsawy, Ilse Manet, and Barbara Ventura. "Cellulose Acetate Fabrics Loaded with Rhodamine B Hydrazide for Optical Detection of Cu(II)." Molecules 25, no. 16 (2020): 3751. http://dx.doi.org/10.3390/molecules25163751.

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In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor. We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure. Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials. Absorption and emission

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29

Chan, Clifford M. "An Improved Synthesis of A Chemiluminescent Cyclic Hydrazide: N-(7-Aminobutyl)-N-Ethyl-Naphthalene-1,2-Dicarboxylic Hydrazide." Synthetic Communications 19, no. 11-12 (1989): 1981–85. http://dx.doi.org/10.1080/00397918908052590.

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30

Gomes, Dominique, José Carlos Pinto, and Cristiano Borges. "Determination of hydrazide content in poly(oxadiazole-hydrazide) copolymers by NMR and thermal analysis." Polymer 44, no. 20 (2003): 6223–33. http://dx.doi.org/10.1016/s0032-3861(03)00638-4.

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31

Kim, Yeojin, Kwang Ho Song, and Sunwoo Lee. "Synthesis of S-aryl thioesters via palladium-catalyzed thiocarbonylation of aryl iodides and aryl sulfonyl hydrazides." Organic Chemistry Frontiers 7, no. 19 (2020): 2938–43. http://dx.doi.org/10.1039/d0qo00748j.

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32

Zhang, Jie, Tianhua Shen, Lijuan Xu, et al. "Synthesis and Bioactivities of Clopyralid Hydrazide-Hydrazones." Synthetic Communications 40, no. 6 (2010): 814–20. http://dx.doi.org/10.1080/00397910903013762.

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33

Khattab, Sherine. "Synthesis and Biological Activity of Novel Amino Acid-(N'-Benzoyl) Hydrazide and Amino Acid-(N'-Nicotinoyl) Hydrazide Derivatives." Molecules 10, no. 9 (2005): 1218–28. http://dx.doi.org/10.3390/10091218.

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34

Chandrasekhar, Vadapalli, Venkatasubbaiah Krishnan, Arunachalampillai Athimoolam, and Gurusamy Thangavelu Senthil Andavan. "New hybrid inorganic-organic polymers containing cyclophosphazenes as pendant groups: Cyclophosphazene ligands containing hydrazone linkages and their conversion to polymers." Canadian Journal of Chemistry 80, no. 11 (2002): 1415–20. http://dx.doi.org/10.1139/v02-099.

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The reaction of the cyclotriphosphazene N3P3Cl5[O-C6H4-p-C6H4-p-CH=CH2] (2) with 10 equiv of N-methylhydrazine proceeds in a regio-specific manner to afford the multi-functional hydrazide N3P3[N(Me)NH2]5[O- C6H4-p-C6H4-p-CH=CH2] (3). Condensation of 3 with o-hydroxy benzaldehyde or pyridine-2-carboxaldehyde affords the corresponding hydrazones N3P3[N(Me)N=CH-C6H4-o-OH]5[O-C6H4-p-C6H4-p-CH=CH2] (4) and N3P3[N(Me)N=CH-C6H4N]5[O-C6H4-p-C6H4-p-CH=CH2] (5), respectively. These hydrazones can be homopolymerized to afford polymers 6 and 7 containing multi-site coordinating cyclophosphazenes as pendan

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35

Gad, Emad M., Mohamed S. Nafie, Elsayed H. Eltamany, Magdy S. A. G. Hammad, Assem Barakat, and Ahmed T. A. Boraei. "Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation." Molecules 25, no. 11 (2020): 2523. http://dx.doi.org/10.3390/molecules25112523.

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A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1. An interesting cyclization was obtained when the amino-ester 1 reacted with ethyl isothiocyanate to give the benzo[4,5]thieno[2,3-d][1,3]thiazin-4-one 3. Acylation of the amino-ester 1 with chloroacetyl chloride in DCM and Et3N afforded the acylated ester 4. The amino-ester 1 was cyclized to benzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 8, which was reacted with some alkylating agents leading to alkylation at nitrogen 9–13. Hydrazide 14 was utilized as a synthon for the

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36

Dyniewicz, Jolanta, Piotr F. J. Lipiński, Piotr Kosson, Marta Bochyńska-Czyż, Joanna Matalińska, and Aleksandra Misicka. "Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus." Molecules 25, no. 15 (2020): 3429. http://dx.doi.org/10.3390/molecules25153429.

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In the present contribution, we analyze the influence that C-terminal extension of short opioid peptide sequences by organic fragments has on receptor affinity, in vivo analgesic activity, and antimelanoma properties. The considered fragments were based on either N-acylhydrazone (NAH) or N′-acylhydrazide motifs combined with the 3,5-bis(trifluoromethyl)phenyl moiety. Eleven novel compounds were synthesized and subject to biological evaluation. The analyzed compounds exhibit a diversified range of affinities for the µ opioid receptor (MOR), rather low δ opioid receptor (DOR) affinities, and no

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37

Abu Ali, Ola A., Hosam A. Saad, and Bodor M. A. Al Malki. "Synthesis of Some New Folic Acid-Based Heterocycles of Anticipated Biological Activity." Molecules 26, no. 2 (2021): 368. http://dx.doi.org/10.3390/molecules26020368.

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To date, no fused heterocycles have been formed on folic acid molecules; for this reason, and others, our target is to synthesize new derivatives of folic acid as isolated or fused systems. Folic acid 1 reacted with ethyl pyruvate, triethyl orthoformate, ethyl chloroformate, thioformic acid hydrazide, and aldehydes to give new derivatives of folic acid 2–6a,b. Moreover, It reacted with benzylidene malononitrile, acetylacetone, ninhydrin, ethyl acetoacetate, ethyl cyanoacetate, and ethyl chloroacetate to give the pteridine fused systems 10–15, respectively. Ethoxycarbonylamino derivate 5 reacte

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38

Horchani, Mabrouk, Gerardo Della Sala, Alessia Caso, et al. "Molecular Docking and Biophysical Studies for Antiproliferative Assessment of Synthetic Pyrazolo-Pyrimidinones Tethered with Hydrazide-Hydrazones." International Journal of Molecular Sciences 22, no. 5 (2021): 2742. http://dx.doi.org/10.3390/ijms22052742.

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Chemotherapy represents the most applied approach to cancer treatment. Owing to the frequent onset of chemoresistance and tumor relapses, there is an urgent need to discover novel and more effective anticancer drugs. In the search for therapeutic alternatives to treat the cancer disease, a series of hybrid pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered with hydrazide-hydrazones, 5a–h, was synthesized from condensation reaction of pyrazolopyrimidinone-hydrazide 4 with a series of arylaldehydes in ethanol, in acid catalysis. In vitro assessment of antiproliferative effects against MCF-7 breast can

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39

Nacer, Salah Neghmouche, and Touhami Lanez. "The Effect of Hydrazide Group on the Oxydation of Ferrocene at Two Different Electrodes Using Rotating Disk Electrode (RDE) in Organic Medium." International Letters of Chemistry, Physics and Astronomy 12 (September 2013): 1–7. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.12.1.

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Through this work we adopted Rotating Disk Electrode (RDE) Voltammetry to study the kinetics of oxidation and the effect of hydrazide group on ferrocene in organic medium. Thus, two different electrodes (Pt and Ge) were used in order to determine this latter. According to the ferrocene taken as a witness the hydrazide group related to the ferrocene made oxidation more difficult. This ferrocenic derivative showed an electrochemical stability, a reversible electrochemical system and an electronic attractor effect of these substitutional ferrocene groups. Finally, we calculated some electrochemic

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40

Lemay, Mathieu, John Trant, and William W. Ogilvie. "Hydrazide-catalyzed 1,3-dipolar nitrone cycloadditions." Tetrahedron 63, no. 47 (2007): 11644–55. http://dx.doi.org/10.1016/j.tet.2007.08.110.

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41

Gao, Shi-Chang, Kang Wan, Xu Fang, Yong-Xue Li, Min Xue, and Yong Yang. "Determination of association constants and FRET in hydrazide-based molecular duplex strands." Organic Chemistry Frontiers 7, no. 17 (2020): 2419–25. http://dx.doi.org/10.1039/d0qo00746c.

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The association constants for the hydrazide-based molecular duplex strands can be determined via monitoring the pyrene excimer emission. By mixing pyrene and perylene labelled oligomers, supramolecular substitution reactions induced efficient FRET.

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42

Bondock, Samir, Abd El-Gaber El-Tarhoni, and Ahmed A. Fadda. "Utility of cyanoacetic acid hydrazide in heterocyclic synthesis." Arkivoc 2006, no. 9 (2006): 113–56. http://dx.doi.org/10.3998/ark.5550190.0007.905.

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43

Chen, Chenchen, Sijian Li, Yiqun Chen, Huajian Xu, and Yiming Li. "Synthesis of Nesiritide via Ligation of Peptide Hydrazide." Chinese Journal of Organic Chemistry 34, no. 7 (2014): 1452. http://dx.doi.org/10.6023/cjoc201401039.

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44

Ibrahim, Tarek S., Ehab S. Taher, Ebtihal Samir, et al. "In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors." Molecules 25, no. 14 (2020): 3125. http://dx.doi.org/10.3390/molecules25143125.

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Two sets of diphenyl ether derivatives incorporating five-membered 1,3,4-oxadiazoles, and their open-chain aryl hydrazone analogs were synthesized in good yields. Most of the synthesized compounds showed promising in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv. Three diphenyl ether derivatives, namely hydrazide 3, oxadiazole 4 and naphthylarylidene 8g exhibited pronounced activity with minimum inhibitory concentrations (MICs) of 0.61, 0.86 and 0.99 μg/mL, respectively compared to triclosan (10 μg/mL) and isoniazid (INH) (0.2 μg/mL). Compounds 3, 4, and 8g showed t

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45

Maniak, Halina, Michał Talma, Konrad Matyja, Anna Trusek, and Mirosław Giurg. "Synthesis and Structure-Activity Relationship Studies of Hydrazide-Hydrazones as Inhibitors of Laccase from Trametes versicolor." Molecules 25, no. 5 (2020): 1255. http://dx.doi.org/10.3390/molecules25051255.

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A series of hydrazide-hydrazones 1–3, the imine derivatives of hydrazides and aldehydes bearing benzene rings, were screened as inhibitors of laccase from Trametes versicolor. Laccase is a copper-containing enzyme which inhibition might prevent or reduce the activity of the plant pathogens that produce it in various biochemical processes. The kinetic and molecular modeling studies were performed and for selected compounds, the docking results were discussed. Seven 4-hydroxybenzhydrazide (4-HBAH) derivatives exhibited micromolar activity Ki = 24–674 µM with the predicted and desirable competiti

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46

Zaki, Remon M., Adel M. Kamal El Dean, Maisa I. Abd El Monem, and Mohamed A. Seddik. "Novel synthesis and reactions of pyrazolyl-substituted tetrahydrothieno[2,3-c]isoquinoline derivatives." Heterocyclic Communications 22, no. 2 (2016): 103–9. http://dx.doi.org/10.1515/hc-2015-0204.

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AbstractTreatment of isoquinolinecarboxamide 4a with triethyl orthoformate, chloroacetyl chloride or carbon disulfide afforded the pyrimidinone 7, oxopyrimidinethione 12 and chloromethylpyrimidinone 18, respectively. These products were used as versatile starting materials for synthesis of other heterocyclic compounds. The heterocyclic hydrazide 6 was also obtained.

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Sanad, Sherif M. H., Azza M. Abdel-Fattah, Fawzy A. Attaby, and Mohamed A. A. Elneairy. "Synthesis and characterization of novel bis(pyridine-2(1H)-thiones) and their bis(2-methylsulfanylpyridines) incorporating 2,6-dibromophenoxy moiety." Canadian Journal of Chemistry 97, no. 1 (2019): 53–60. http://dx.doi.org/10.1139/cjc-2017-0721.

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The novel 1,4-bis(2,6-dibromo-4-formylphenoxy)butane (3), prepared from 3,5-dibromobenzaldehyde (1), reacted with different hydrazines 4a–4d and active methylene containing compounds 9a–9d to give the corresponding bis(hydrazones) 5a–5d and bis(cinnamonitriles) 11a–11d, respectively. Both bis(2-cyanoacetic acid hydrazide) derivative 5d and bis(thioacrylamide) derivative 11a were taken as synthetic precursors for the synthesis of the target molecules bis(pyridine-2(1H)-thione) derivative 10 and 13a–13c and their bis(2-methylsulfanylpyridine) derivative 14 and 17a–17c. Another synthetic route wa

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Katrusiak, Andrzej, and Anna Katrusiak. "Polymorph-specific chlorination of maleic-hydrazide." Journal of Molecular Structure 647, no. 1-3 (2003): 203–10. http://dx.doi.org/10.1016/s0022-2860(02)00525-2.

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Bordoloi, Manobjyoti, Rumi Kotoky, Jiban J. Mahanta, Tarun C. Sarma, and Purnendu B. Kanjilal. "Anti-genotoxic hydrazide from Crinum defixum." European Journal of Medicinal Chemistry 44, no. 6 (2009): 2754–57. http://dx.doi.org/10.1016/j.ejmech.2008.09.041.

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Liu, Zhongshan, Junjie Ou, Hongwei Wang, Xin You, and Mingliang Ye. "Synthesis and Characterization of Hydrazide-Linked and Amide-Linked Organic Polymers." ACS Applied Materials & Interfaces 8, no. 46 (2016): 32060–67. http://dx.doi.org/10.1021/acsami.6b11572.

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