Relevant bibliographies by topics / Organic synthesis ; Natural products ; Synthetic organic chemistry

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Organic synthesis ; Natural products ; Synthetic organic chemistry'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Organic synthesis ; Natural products ; Synthetic organic chemistry"

1

Ramachandran, P. Veeraraghavan, M. Venkat Ram Reddy, and Herbert C. Brown. "Tandem allylboration-ring-closing metathesis reactions for the preparation of biologically active molecules." Pure and Applied Chemistry 75, no. 9 (2003): 1263–75. http://dx.doi.org/10.1351/pac200375091263.

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The development of asymmetric synthesis during the past two decades aided organic chemists considerably in the synthesis of complex natural products. Organoborane chemistry continues to play an important role in asymmetric synthesis. One of the important reactions that has become very common in the arsenal of synthetic chemists is allylboration and related reactions. Another important reaction that has recently attained enormous importance in organic chemistry is the ring-closing metathesis (RCM) reaction. Indeed, a combination of allylboration and RCM reactions provides an excellent route to
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Speck, Klaus, and Thomas Magauer. "The chemistry of isoindole natural products." Beilstein Journal of Organic Chemistry 9 (October 10, 2013): 2048–78. http://dx.doi.org/10.3762/bjoc.9.243.

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This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type alkaloids. Concerning their biological activity, molecular structure and synthesis, we have limited this review to the most inspiring examples. Within different congeners, we have selected a few members and discussed the synthetic routes in more detail.
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Petrovčič, Jan, Chad Nicholas Ungarean, and David Sarlah. "Recent Chemical Methodology Advances in the Total Synthesis of Meroterpenoids." Acta Chimica Slovenica 68, no. 2 (2021): 247–67. http://dx.doi.org/10.17344/acsi.2021.6921.

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Heterogeneity of meroterpenoids arising from their dual biosynthetic origins is constantly provoking synthetic chemists to utilize their ingenuity and revise their retrosynthetic logic. By studying recent publications on meroterpenoid synthesis,tremendous advances in the field of synthetic organic chemistry can be witnessed. This feature article covers some of the most intriguing total syntheses and synthetic studies towards the meroterpenoid class of natural products from the last five years.
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Ortiz, Aurelio, Miriam Castro, and Estibaliz Sansinenea. "3,4-Dihydroisocoumarins, Interesting Natural Products: Isolation, Organic Syntheses and Biological Activities." Current Organic Synthesis 16, no. 1 (2019): 112–29. http://dx.doi.org/10.2174/1570179415666180924123439.

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Background:3,4-dihydroisocoumarins are an important small group belonging to the class of naturally occurring lactones isolated from different bacterial strains, molds, lichens, and plants. The structures of these natural compounds show various types of substitution in their basic skeleton and this variability influences deeply their biological activities. These lactones are structural subunits of several natural products and serve as useful intermediates in the synthesis of different heterocyclic molecules, which exhibit a wide range of biological activities, such as anti-inflammatory, antipl
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Fang, Xianhe, and Xiangdong Hu. "Advances in the Synthesis of Lignan Natural Products." Molecules 23, no. 12 (2018): 3385. http://dx.doi.org/10.3390/molecules23123385.

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Lignans comprise a family of secondary metabolites existing widely in plants and also in human food sources. As important components, these compounds play remarkable roles in plants' ecological functions as protection against herbivores and microorganisms. Meanwhile, foods rich in lignans have revealed potential to decrease of risk of cancers. To date, a number of promising bioactivities have been found for lignan natural products and their unnatural analogues, including antibacterial, antiviral, antitumor, antiplatelet, phosphodiesterase inhibition, 5-lipoxygenase inhibition, HIV reverse tran
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Nasir, Shah Bakhtiar, Noorsaadah Abd Rahman, and Chin Fei Chee. "Enantioselective Syntheses of Flavonoid Diels-Alder Natural Products: A Review." Current Organic Synthesis 15, no. 2 (2018): 221–29. http://dx.doi.org/10.2174/1570179414666170821120234.

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Background: The Diels-Alder reaction has been widely utilised in the syntheses of biologically important natural products over the years and continues to greatly impact modern synthetic methodology. Recent discovery of chiral organocatalysts, auxiliaries and ligands in organic synthesis has paved the way for their application in Diels-Alder chemistry with the goal to improve efficiency as well as stereochemistry. Objective: The review focuses on asymmetric syntheses of flavonoid Diels-Alder natural products that utilize chiral ligand-Lewis acid complexes through various illustrative examples.
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Ball, Philip. "Synthetic organic chemistry in China: building on an ancient tradition—an interview with Qi-Lin Zhou and Xiaoming Feng." National Science Review 4, no. 3 (2017): 437–40. http://dx.doi.org/10.1093/nsr/nwx035.

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Abstract If the core of chemistry is making molecules, then the construction of those found in nature—natural products—has long been regarded as one of the highest forms of the art in synthesis. These molecules, produced by living organisms for a variety of purposes, are a key source of pharmaceuticals such as antibiotics and anticancer agents. The medicinal value of natural products has been known for centuries via herbal treatments, and such compounds are still collected, refined and screened for potential drugs today, sometimes being identified from local ‘folk medicine’ practices. By ident
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Thorat, Sagar S., and Ravindar Kontham. "Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products." Organic Chemistry Frontiers 8, no. 9 (2021): 2110–62. http://dx.doi.org/10.1039/d0qo01421d.

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The furo-pyranone framework is widely present in the molecular structure of various biologically potent natural products and un-natural small molecules, and it represents a valuable target in synthetic organic chemistry and medicinal chemistry.
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Beemelmanns, Christine, Dávid Roman, and Maria Sauer. "Applications of the Horner–Wadsworth–Emmons Olefination in Modern Natural Product Synthesis." Synthesis 53, no. 16 (2021): 2713–39. http://dx.doi.org/10.1055/a-1493-6331.

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AbstractThe Horner–Wadsworth–Emmons (HWE) reaction is one of the most reliable olefination reaction and can be broadly applied in organic chemistry and natural product synthesis with excellent selectivity. Within the last few years HWE reaction conditions have been optimized and new reagents developed to overcome challenges in the total syntheses of natural products. This review highlights the application of HWE olefinations in total syntheses of structurally different natural products covering 2015 to 2020. Applied HWE reagents and reactions conditions are highlighted to support future synthe
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Eggert, Alina, Christoph Etling, Dennis Lübken, Marius Saxarra, and Markus Kalesse. "Contiguous Quaternary Carbons: A Selection of Total Syntheses." Molecules 25, no. 17 (2020): 3841. http://dx.doi.org/10.3390/molecules25173841.

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Contiguous quaternary carbons in terpene natural products remain a major challenge in total synthesis. Synthetic strategies to overcome this challenge will be a pivotal prerequisite to the medicinal application of natural products and their analogs or derivatives. In this review, we cover syntheses of natural products that exhibit a dense assembly of quaternary carbons and whose syntheses were uncompleted until recently. While discussing their syntheses, we not only cover the most recent total syntheses but also provide an update on the status quo of modern syntheses of complex natural product
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Dissertations / Theses on the topic "Organic synthesis ; Natural products ; Synthetic organic chemistry"

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Wu, Boshen. "Synthesis of taurospongin A and other biologically active natural products." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:37a34bc4-efb4-4a6b-9d44-a3ad1c8ae0be.

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This thesis firstly describes a synthesis of the natural product taurospongin A, a potent DNA polymerase beta inhibitor. Sharpless asymmetric dihydroxylation on olefin <b>E-1.60</b> followed by selective deoxygenation at C(2) via Barton‒McCombie reaction delivers the desired C(1)–C(10) carboxylic acid core. Subsequent esterification of the C(1)–C(10) fragment with C(1′)–C(25′) fatty acid furnishes the natural product in 13.5% yield. The structure of an unnamed natural product <b>2.14</b> isolated in 1974 is proven to be misassigned by previous studies within the Robertson group. As described i
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Nimkar, Sandeep Krishnaji. "Studies in asymmetric synthesis: Development of new synthetic methods for syntheses of natural products." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186538.

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The research, to be discussed in three chapters, involves the development of new synthetic methods which are applicable to the total synthesis of many natural products. Chapter 1: As a part of a program to synthesize new auxiliary agents for asymmetric synthesis, we have prepared a structurally rigid acetal from norbornene in three chemical steps. This enantiomerically pure acetal has been used for resolution of racemic α-hydroxy esters and might be applied as a chiral auxiliary for diastereoselective reactions. Chapter 2: The Calicheamicin and Esperamicin antibiotics have shown remarkable bio
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Källström, Jan Eddy Adolf. "Synthesis studies towards daphlongeranine B." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:638685a8-da64-488b-b65d-ba9a2111d4fb.

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This thesis describes the development of a synthetic route towards daphlongeranine B, an alkaloid isolated from the fruits of Daphniphyllum longeracemosum, by utilising an intramolecular Michael addition to form its unique tricyclic core. <strong>Chapter 1</strong> gives a general introduction to the family of Daphniphyllum alkaloids together with some recent examples, from the literature, illustrating some synthetic attempts towards structurally similar alkaloids. This chapter also features our retrosynthetic analysis of daphlongeranine B. <strong>Chapter 2</strong> details the synthesis of t
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Leslie, Pauline. "Studies towards the synthesis of chlorinated natural products." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268989.

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Welch, Rosemary. "The development of new synthetic methods towards the synthesis of biologically active natural products." Thesis, University of Portsmouth, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292089.

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Shah, Rushabh Surendra. "Total syntheses of the nakinadine alkaloids." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:c022e538-9ff8-4914-8c17-dc0b3ed1fbae.

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This thesis is concerned with the development of methodology for the asymmetric syntheses of the nakinadine family of marine alkaloids and through these synthetic endeavours, seeks to confirm the structure and assign the relative and absolute configurations of these alkaloids for the first time.
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Dyson, Bryony Sara. "Determining the structures of halogenated marine natural products by total synthesis." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:31737a99-a13c-4110-b36d-1c043b66565b.

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Elatenyne, a brominated C<sub>15</sub> acetogenin isolated from the red Laurencia elata marine algae, was originally assigned a pyranopyran structure. Previous total synthesis of the pyranopyran structure has found this assignment to be incorrect. During this work the revised 2,2’-bifuranyl skeleton of elatenyne was suggested, but this skeleton has 32 possible diastereomers. The most likely diastereomer of elatenyne was predicted using computational <sup>13</sup>C NMR chemical shift calculation in combination with the possible stereochemical outcomes from the proposed biosynthesis. Chapter 1 i
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O'Riordan, Timothy Jeremiah Cornelius. "Synthesis of the pyrrolidinone core of oxazolomycin A." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:298746d3-69df-47b9-8a83-7949df1c94dc.

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This thesis describes the development of synthetic strategies towards the densely functionalised pyrrolidinone core of the polyene &beta;-lactone-&gamma;-lactam antibiotic oxazolomycin A. <strong>Chapter 1 The oxazolomycins</strong> The oxazolomycins, a unique class of biologically active molecules containing a spiro-fused β-lactone-γ-lactam ring system are introduced. The isolation, structural elucidation and biological properties of the oxazolomycins as well as those of the structurally related inthomycins are reviewed. <strong>Chapter 2 Previous syntheses</strong> The two total syntheses of
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Phillips, Andrew. "Studies towards the total synthesis of patellazole B." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269364.

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The patellazoles are a family of marine polyketide natural products first isolated from Lissoclinum patella in 1988 by both the Moore and Ireland groups. They exhibit significant cytotoxicity against the HCT 116 human colon tumour cells. To date however, their full 3D stereostructure have yet to be elucidated, which has hindered their development as potential drugs, and hampered full investigation into their biological mechanism of action and has deterred total synthesis efforts. This thesis describes synthetic efforts towards Patellazole B, which exhibits the highest potency of the three main
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Elbert, Bryony L. "The synthesis and applications of cyclic alkenylsiloxanes." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a332365e-22f2-4449-b517-3fd8a62ea8a3.

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This thesis describes the development of robust methodology to access cyclic alkenylsiloxanes, and their subsequent application in Hiyama-Denmark cross couplings. An early chapter shows the identification of Lindlar reduction conditions capable of generating cyclic alkenylsiloxanes from alkynylsiloxanes in high yields. The use of such species in Hiyama-Denmark cross coupling is then examined, with particular emphasis on the development of fluoride-free conditions, previously unreported for this class of organosilane. A ring-size dependent orthogonality is revealed, where 5-membered cyclic alke
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Books on the topic "Organic synthesis ; Natural products ; Synthetic organic chemistry"

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Asymmetric synthesis of natural products. Wiley, 2012.

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Koskinen, Ari. Asymmetric synthesis of natural products. Wiley, 2012.

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Li, Jie Jack. Total Synthesis of Natural Products: At the Frontiers of Organic Chemistry. Springer Berlin Heidelberg, 2012.

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Rahman, Atta-ur. Stereoselective synthesis. Elsevier, 1996.

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Tian ran chan wu zi yuan hua xue: Resources chemistry of natural products. Ke xue chu ban she, 2008.

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Summer School "A. Corbella" (23rd 1998 Università di Milano). Seminars in organic synthesis: XXIII Summer School "A. Corbella", June 15-19, 1998, Palazzo Feltrinelli, Università degli Studi di Milano, Gargnano (BS). Polo Editoriale Chimico, 1998.

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The way of synthesis: Evolution of design and methods for natural products. Wiley-VCH, 2007.

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Guide to the LEED AP homes exam. Wiley, 2012.

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ApSimon, John. Total Synthesis of Natural Products. Wiley & Sons, Incorporated, John, 2009.

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ApSimon, John. Total Synthesis of Natural Products. Wiley & Sons, Incorporated, John, 2009.

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Book chapters on the topic "Organic synthesis ; Natural products ; Synthetic organic chemistry"

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Wang, Qian, Jie-Ping Zhu, Kyriacos C. Nicolaou, Henry N. C. Wong, and Wei-Dong Li. "Total Synthesis of Natural Products and the Synergy with Synthetic Methodology." In Organic Chemistry - Breakthroughs and Perspectives. Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527664801.ch2.

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Paquette, Leo A., and Annette M. Doherty. "Synthesis of Diquinane Natural Products." In Reactivity and Structure Concepts in Organic Chemistry. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72598-2_8.

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Paquette, Leo A., and Annette M. Doherty. "Synthesis of Triquinane Natural Products." In Reactivity and Structure Concepts in Organic Chemistry. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72598-2_9.

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Schafroth, Michael A., and Erick M. Carreira. "Synthesis of Phytocannabinoids." In Progress in the Chemistry of Organic Natural Products. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45541-9_2.

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Lackner, Gregory L., Kyle W. Quasdorf, and Larry E. Overman. "Visible-Light Photocatalysis in the Synthesis of Natural Products." In Visible Light Photocatalysis in Organic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2018. http://dx.doi.org/10.1002/9783527674145.ch9.

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Flessner, Timo, Rolf Jautelat, Ulrich Scholz, and Ekkehard Winterfeldt. "Cephalostatin Analogues — Synthesis and Biological Activity." In Progress in the Chemistry of Organic Natural Products. Springer Vienna, 2004. http://dx.doi.org/10.1007/978-3-7091-0581-8_1.

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Paquette, Leo A., and Annette M. Doherty. "Synthesis of Nonpolycyclopentanoid Natural Products by Way of Diquinane Intermediates." In Reactivity and Structure Concepts in Organic Chemistry. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72598-2_7.

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Franzyk, H. "Synthetic Aspects of Iridoid Chemistry." In Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6341-2_1.

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León, Alejandra, Mayela Del-Ángel, José Luis Ávila, and Guillermo Delgado. "Phthalides: Distribution in Nature, Chemical Reactivity, Synthesis, and Biological Activity." In Progress in the Chemistry of Organic Natural Products 104. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45618-8_2.

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Bernardi, Darlon Irineu, Fernanda Oliveira das Chagas, Afif Felix Monteiro, Gabriel Franco dos Santos, and Roberto Gomes de Souza Berlinck. "Secondary Metabolites of Endophytic Actinomycetes: Isolation, Synthesis, Biosynthesis, and Biological Activities." In Progress in the Chemistry of Organic Natural Products 108. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-01099-7_3.

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Conference papers on the topic "Organic synthesis ; Natural products ; Synthetic organic chemistry"

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Pachlatko, J. "Natural Products in Crop Protection." In The 2nd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1998. http://dx.doi.org/10.3390/ecsoc-2-01701.

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Couture, Axel, Marc Lamblin, Anne Moreau, Eric Deniau, Stéphane Lebrun, and Pierre Grandclaudon. "New Developments of the Parham Cyclization Process. Applications in Natural Products Synthesis." In The 9th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2005. http://dx.doi.org/10.3390/ecsoc-9-01479.

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Fonseca, André, Maria Matos, Saleta Vazquez-Rodriguez, et al. "Structural Modifications on Natural-based Products: Synthetic Strategies and Biological Applications." In The 18th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-b023.

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Thiericke, Ralf, Yuan-Qing Tang, Isabel Sattler, Susanne Grabley, and Xiao-Zhang Feng. "Parallel Chromatography in Natural Products Chemistry: Isolation of New Secondary Metabolites from Streptomyces sp." In The 4th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01914.

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Cortés, Iván, Andrea Bracca, and Teodoro Kaufman. "Short and efficient first total synthesis of the natural product chromanone A, a chromone derivative from the algicolous marine fungus <em>Penicillium</em> sp." In The 24th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2020. http://dx.doi.org/10.3390/ecsoc-24-08300.

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Bulavka, Vladimir, and Vasiliy Aristov. "Synthesis of 1,2,4,5-benzenetetracarboxylic dianhydride – 4,4’-diaminodiphenyl ether 1 : 2 and 2 : 1 condensation products." In The 12th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2008. http://dx.doi.org/10.3390/ecsoc-12-01234.

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Ramírez Sánchez, David, Danilo Gonzalez Forero, Luis Garcia Sánchez, and Pablo Ramos. "Theoretical And Experimental Exploration Of Organic Synthesis Routes To Obtain Natural Rubber Analogues." In The 17th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-d007.

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Castro, María Julia, Ana Paula Murray, María Belén Faraoni, Angel G. Ravelo, and Ana Estévez Braun. "Synthesis of 3,16,30-trioxolup-20(29)-ene, a selective butyrylcholinesterase inhibitor, from a natural triterpene." In The 17th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-b009.

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Cantrel, Laurent, Thierry Albiol, Loïc Bosland, et al. "IRSN R&D Actions on FP Behaviour for RCS, Containment and FCVS in Severe Accident Conditions." In 2016 24th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/icone24-61104.

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This paper deals with near past, ongoing and planned R&amp;D works on fission products (FPs) behaviour in Reactor Cooling System (RCS), containment building and in Filtered Containment Venting Systems (FCVS) for severe accident (SA) conditions. For the last topic, in link with the Fukushima post-accident management and possible improvement of mitigation actions for such SA, the FCVS topic is again on the agenda (see Status Report on Filtered Containment Venting, OECD/NEA/CSNI, Report NEA/CSNI/R(2014)7, 2014.) with a large interest at the international scale. All the researches are collaborativ
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