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Dissertations / Theses on the topic 'Organic Synthessis'

Author: Grafiati

Published: 20 July 2024

Last updated: 31 July 2025

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1

Paradis, Michel 1976. "The design and synthessis of platinum-based DNA intercalators /." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31523.

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Over the past years, considerable attention has focused on the synthesis of small complexes that can bind and react at specific DNA sequences. This understanding of how to target DNA sites with specificity becomes important for nucleotide probing and novel chemotherapeutics.<br>Inert and stable transition-metal complexes are already being used for this purpose. Square planar platinum (II) complexes containing an aromatic heterocyclic ligand can insert and stack between the double helix base pairs. Two known ligands, DPPZ and phi, do intercalate DNA when chelating ruthenium, rhodium, or osmium.

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2

Phung, Bich Tuyen. "Etude de la sélectivité dans la réaction de Buchner." Electronic Thesis or Diss., Université Grenoble Alpes, 2024. https://theses.hal.science/tel-04651531.

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Le travail présenté dans ce manuscrit est divisé en deux grandes parties. Dans un premier temps, une étude sera présentée sur des problème de chimiosélectivité observés lors de la réaction de transfert de carbène. Des composés diazo différemment substitués ont été généré comme précurseur de carbène, et la réaction de transfert de carbène a été effectuée en présence de Rh2(OAc)4. Les résultats montrent une compétition entre la réaction de Buchner et l’insertion C‒H en position benzylique, dépendant de la substituant du diazo. Des calculs de DFT ont ensuite été réalisés pour compléter les inform

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3

Trupina, Snjezana. "Synthesis of Metalloporphyrins with Oligothiophenes as Probes for Amyloid Diseases." Thesis, Linköping University, Linköping University, Organic Chemistry, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-57989.

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<p>Abnormal aggregation of misfolded proteins is related to numerous neurodegenerative diseases, which include Alzheimer’s, Parkinson’s disease and prion diseases. Luminescent conjugated probes (LCPs) have been used as dyes for these supramolecular assemblies termed amyloid fibrils. To these probes, metalloporphyrin (MP) derivates have been attached to achieve new spectroscopic properties, which will allow for new ways to study protein aggregation diseases.</p><p>In this thesis the synthesis of two different LCPs anchored porphyrin derivates are described. The LCPs are synthesized from 3-thiop

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4

Tilliet, Mélanie. "Synthesis and study of new oxazoline-based ligands." Doctoral thesis, KTH, Organisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4858.

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This thesis deals with the study of oxazoline-based ligands in metal-catalyzed asymmetric reactions. The first part describes the synthesis of six new bifunctinal pyridine-bis(oxazoline) ligands and their applications in asymmetric metal-catalysis. These ligands, in addition to a Lewis acid coordination site, are equipped with a Lewis basic part in the 4-position of the oxazoline rings. Dual activation by means of this system was probed in cyanide addition to aldehydes. The second part is concerned with the synthesis of two pyridine-bis(oxazoline) ligands bearing bulky triazole groups in the 4

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5

Winberg, Karl Johan. "Carborane Derivatives for Nuclide Therapy and Imaging : Synthesis and Radio-labelling." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3561.

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6

Fyrner, Timmy. "Synthesis of Structures Related to Antifreeze Glycoproteins." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11941.

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<p>In this thesis, synthesis of structures related to antifreeze glycoproteins (AFGPs) are presented. Synthetic routes to a protected carbohydrate derivative, 2,3,4,6-tetra-O-benzyl-β-galactopyranosyl-(1→3)-2-deoxy-2-azido-4,6-di-O-benzyl-β-D-thio-1-galactopyranoside, and a tBu-Ala-Thr-Ala-Fmoc tripeptide, are described. These compounds are meant to be used in the assembly of AFGPs and analogues thereof. A Gal-GlcN disaccharide was synthesized via glycosylation between the donor, bromo-2-O-benzoyl-3,4,6-tri-O-benzyl-α-Dgalactopyranoside, and acceptor, ethyl 4,6-O-benzylidene-2-deoxy-2-N-phthal

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7

Larsson, Andreas. "Synthesis, structure and conformation of oligo- and polysaccharides." Doctoral thesis, Stockholm University, Department of Organic Chemistry, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-172.

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<p>Carbohydrates are a complex group of biomolecules with a high structural diversity. Their almost omnipresent occurrence has generated a broad field of research in both biology and chemistry. This thesis focuses on three different aspects of carbohydrate chemistry, synthesis, structure elucidation and the conformational analysis of carbohydrates.</p><p>The first paper describes the synthesis of a penta- and a tetrasaccharide related to the highly branched capsular polysaccharide from <i>Streptococcus pneumoniae </i>type 37. In the second paper, the structure of the O-antigenic repeating unit

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8

Esfandiarfard, Keyhan. "Novel Organophosphorus Compounds for Materials and Organic Synthesis." Doctoral thesis, Uppsala universitet, Molekylär biomimetik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328295.

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This thesis is devoted to the development of new organophosphorus compounds for potential uses in material science and as reagents in Organic Chemistry. Organophosphorus compounds in a single molecule or organic electronics context are appealing as the phosphorous centers perturb the electronic properties of the π-conjugated systems while at the same time provide synthetic handles for subsequent synthetic modifications. As such, new synthetic methodology to such compounds and the exploration of new building blocks is of considerable interest. In a different study, novel organophosphorus compou

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9

BERTON, GIACOMO. "SYNTHESIS OF TRIPHENYLENES FOR SUPRAMOLECULAR APPLICATIONS." Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2969361.

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In this Doctoral Thesis, through several examples of new chemical modifications characterized by high yields and selectivities and new supramolecular structures, held together by a wide range of intermolecular forces forming several new host systems, we reached our target to revamp triphenylene and derivatives as a new molecular scaffold in supramolecular chemistry. More specifically, the introduction in our triphenylenic scaffold of alkyl thiol chains allowed the formation of sulphide and disulphide covalent cages, while by insertion of pyridine moieties through Mannich reaction it was possib

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10

Hagberg, Daniel. "Synthesis of Organic Chromophores for Dye Sensitized Solar Cells." Licentiate thesis, Stockholm : Kemi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4600.

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11

Gemma, Emiliano. "Synthesis of Oligosaccharides for Interaction Studies with Various Lectins." Doctoral thesis, Stockholm : Department of Organic Chemistry, Stockholm University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-459.

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12

Eriksson, Tor. "Synthesis of 2-(ethoxy(hydroxy)phosphoryl)-3-phenylpropyl ethanethioate." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-386474.

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13

Velikyan, Irina. "Synthesis, Characterization and Application of 68Ga-labelled Peptides and Oligonucleotides." Licentiate thesis, Uppsala University, Department of Chemistry, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-86136.

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<p>The positron emitting 68Ga radionuclide (T1/2 = 68 min) has the potential of practical interest for clinical PET. The metallic cation, 68Ga3+, is suitable for complexation reactions with chelators either naked or conjugated with macromolecules such as peptides and oligonucleotides. Such labeling procedures require pure and concentrated radiometal preparations, which cannot be sufficiently fulfilled by the presently available 68Ge/68Ga generator eluate. This thesis presents a method to increase the concentration and purity of 68Ga obtained from a commercial 68Ge/68Ga generator. DOTATOC (DOTA

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14

Ayesa, Alvarez Susana. "Design and Synthesis of Amine Building Blocks and Protease Inhibitors." Doctoral thesis, Stockholm : Department of Organic Chemistry, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8038.

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15

Wallner, Olov. "Palladium-Catalyzed Synthesis and Transformations of Organometallic Compounds." Doctoral thesis, Stockholm : Dept. of Organic Chemistry, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-804.

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16

Torssell, Staffan. "Amino Aacohols : stereoselective synthesis and applications in diversity-oriented synthesis." Licentiate thesis, KTH, Chemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-315.

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<p>This thesis is divided into three separate parts with amino alcohols as the common feature. The first part describes the development of a novel three-component approach to the synthesis of α-hydroxy-β-amino esters. Utilizing a highly diastereoselective Rh(II)-catalyzed 1,3-dipolar cycloaddition of carbonyl ylides to various aldimines, syn-α-hydroxy-β-amino esters formed in high yields and excellent diastereoselectivities. This methodology was also applied in a short enantioselective synthesis of the C-13 side-chain of Taxol.</p><p>The second part of the thesis describes a total synthesis of

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17

Ahmed, Mustafe. "Synthesis of imidazopyridazine analogs aiming to improve antibacterial Gram-negative activity." Thesis, Uppsala universitet, Institutionen för läkemedelskemi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449572.

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18

Modin, Judit. "Synthesis and Evaluation of Photoactive Pyridine Complexes for Electron Transfer Studies and Photoelectrochemical Applications." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6146.

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19

O'Neill, Bridget. "Syntheses of novel 2-oxo esters : enzyme substrates designed for asymmetric synthesis." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261316.

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20

Lamprianidis, Panagiotis. "Photoredox catalysis with 10-phenyl-10H- phenothiazine and synthesis of a photocatalytic chiral proline-based organocatalyst." Thesis, KTH, Organisk kemi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-293510.

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Photoredox catalysis applications for the purpose of new synthetic routes in organic and sustainable chemistry are hot topics in organic synthesis today. In the present study, the synthesis of a chiral proline-based organocatalyst functionalized with 10-phenyl-10H phenothiazine (PTH) photocatalytic moietiesis investigated and attempted for the first time. PTH, an organic photocatalyst, isstudied for its photocatalytic activity in different organic reactions, such as dehalogenation of aromatic halides and the pinacol coupling reaction between aromatic aldehydes. These transformations are otherw

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21

Alfredsson, Maria. "Synthesis and Characterization of Acrylfentanyl Metabolites." Thesis, Linköpings universitet, Kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138142.

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Acrylfentanyl is a synthetic opioid that has been widely used in the last year. To help in the fight against synthetic drugs two potential metabolites of acrylfentanyl, one monohydroxy and one dihydroxy were synthesized. These metabolites will hopefully later be implemented in the analytical methods for metabolites of acrylfentanyl in urine by the Swedish National Board of Forensic Medicine. To have metabolites for analysis are very important as they are the main target in drug testing. The method used to synthesize the metabolites is a five-step synthesis with an additional 6th step for the d

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22

Erlandsson, Maria. "Imaging of Enzymes in the Steroid Biosynthetic Pathway : Synthesis of 18F-Labelled Tracers." Doctoral thesis, Uppsala universitet, Organisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89177.

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This thesis deals with the synthesis and development of 18F-labelled alkyl etomidate and vorozole analogues, and their use as positron emission tomography (PET) tracers for the imaging of the steroid enzymes 11β-hydroxylase and aromatase. Two synthetic 18F-labelling approaches to the etomidate and vorozole analogues were developed, and the analogues were evaluated in some biological assays. The two-step labelling method was used to synthesise many compounds for biological evaluation. In the first step, a 18F-labelled intermediate based on a ditosylate or a halogenated diethyl ether was synthes

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23

Santangelo, Ellen M. "Stereoselective syntheses of semichemicals : Applications in ecological chemistry." Doctoral thesis, KTH, Chemistry, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-74.

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<p>This thesis describes the syntheses of semiochemicals and their applications in the development of control methods for pest insects. The compounds synthesized are divided into three groups: 1) Lepidoptera pheromones; 2) methyl substituted chiral pheromones and 3) aphid pheromones. </p><p>Different purification techniques have been explored in order to provide > 99% pure semiochemicals for field tests. Examples of the techniques are uses of urea inclusion complexes, argentum chromatography, low temperature crystallization and what we call the Baeckström isolation technique.</p><p>Iridoids ha

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24

Karimi, Farhad. "[11C]Carbon Monoxide in Palladium- / Selenium-Promoted Carbonylation Reactions : Synthesis of 11C-Imides, Hydrazides, Amides, Carboxylic Acids, Carboxylic Esters, Carbothioates, Ketones and Carbamoyl Compounds." Doctoral thesis, Uppsala universitet, Avdelningen för organisk kemi, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2931.

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[11C]Carbon monoxide in low concentrations has been used in palladium- or seleniummediated carbonylation reactions such as the synthesis of 11C-imides, hydrazides, amides, carboxylic acids, esters, carbothioates, ketones and carbamoyl compounds. In these reactions aryl iodides have been used in most cases. However, less reactive aryl triflate, chloride and bromides were activated using tetrabutylammonium iodide. The reactivities of nucleophiles may have influence on the radiochemical yield of the 11Clabelled compounds. Carboxyamination of aryl halides using aniline derivatives yielded 10% of t

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25

Sjölin, Olof. "Synthesis of Substituted Pyrrolidines." Thesis, KTH, Skolan för kemivetenskap (CHE), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207056.

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The task of medicinal chemists in a drug discoveryproject is to synthesize/design analogues to the screening hits, simultaneouslyincreasing target potency and optimizing the pharmacological properties. This requires a wide selection of moleculesto be synthesized, where both synthetic feasibility and price of startingmaterials are of great importance. In this work, a synthetic pathway from cheapand readily available starting materials to highly modifiable 2,4-disubstitutedpyrrolidines is demonstrated. Previously reported procedures to similarpyrrolidines use expensive catalysts, requires harsh

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26

Sonesten, Victor. "Design and Synthesis of Macrocyclic Peptides as Potential Inhibitors of Lysine-Specific Demethylase 1." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397428.

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27

Toom, Lauri. "Bispidine Derivatives : Synthesis and Interactions with Lewis Acids." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6735.

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28

Thorstensson, Fredrik. "Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library." Doctoral thesis, Linköping : Linköpings universitet, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-4938.

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29

Teodorovic, Peter. "Synthesis of oligosaccharides related to the capsular polysaccharide of Neisseria meningitidis serotype A." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-545.

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In order to find suitable stable vaccine candidates against Neisseria meningitidis group A, several structures related to the capsular polysaccharide have been synthesised. The first part of the thesis describes the synthesis of C-phosphonate analogues starting from glucose. The key step is a Mitsunobu coupling of a methyl C-phosphonate monomer to the 6-hydroxyl group of a 2-acetamido mannose derivative. Contained within this work is a description of an improved synthesis of 2-azido-2-deoxy-D-mannopyranose. The second part outlines the synthesis of structural elements present in the native cap

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30

Adrian, Meredith Jenny. "Design and Synthesis of Inhibitors Targeting the Aspartic Proteases HIV-1 PR and BACE-1." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-29773.

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This thesis describes the synthesis of molecules designed for inhibition of two aspartic proteases, viral HIV-1 PR and human BACE-1. It also reports on the structure activity relationships of the targeted enzyme inhibitors. It is estimated that currently 33 million people are infected with HIV, the causative agent of AIDS. The virus targets T-lymphocytes and macrophages of the human immune system. The HIV-1 PR plays an important role in the viral replication, and by inhibiting the enzyme the disease progression can be slowed down or even halted. Herein is reported the design and synthesis of a

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31

Kalek, Marcin. "Synthesis of C(sp2)-P bonds by palladium-catalyzed reactions : Mechanistic investigations and synthetic studies." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56467.

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This thesis focuses on synthetic and mechanistic aspects of palladium-catalyzed C(sp2)-P bond-forming reactions, with the aim to develop mild and efficient methods for the synthesis of biologically active phosphorus compounds, e.g. DNA analogs. The first part of the thesis is devoted to detailed mechanistic investigations of the palladium-catalyzed C-P cross-coupling reaction, in order to fully understand the underlying chemistry and by rational design of the reaction conditions, improve the overall efficiency of the process and broaden its applicability. In particular influence of palladium c

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32

Tan, Changqing. "Photochemical Silaylide, Silylene and Silene Syntheses." Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc501256/.

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The synthesis of o-(N,N-dimethylamino)methylphenyl tris (trimethylsilyl) silane (II), a photochemical precursor of o- (N,N-dimethylamino) methylphenyl (trimethylsilyl) sila ammonium ylide (intramolecular silylene complex) and otolyl(trimethylsilyl)silylene is reported. Photolysis of II at room temperature in a cyclohexane solution of triethyl silane produced the silylene ylide and the presumably uncomplexed isomer, a silylene, which is trapped to afford the 2-(o-(N,N-dimethylamino)methylphenyl) -1,1,1-triethyl 3,3,3-trimethyltrisilane, 33% yield. A second decomposition pathway, a photodeaminat

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33

Ericsson, Cecilia. "Synthesis of Tetrahydrofuran and Pyrrolidine Derivatives Utilising Radical Reactions : Organochalcogenides in Reductive, Carbonylative and Group-Transfer Cyclisation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4018.

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34

Karimi, Farhad. "[¹¹C]Carbon Monoxide in Palladium- / Selenium-Promoted Carbonylation Reactions : Synthesis of ¹¹C-Imides, Hydrazides, Amides, Carboxylic Acids, Carboxylic Esters, Carbothioates, Ketones and Carbamoyl Compounds." Doctoral thesis, Uppsala University, Organic Chemistry, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2931.

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<p>[<sup>11</sup>C]Carbon monoxide in low concentrations has been used in palladium- or seleniummediated carbonylation reactions such as the synthesis of <sup>11</sup>C-imides, hydrazides, amides, carboxylic acids, esters, carbothioates, ketones and carbamoyl compounds.</p><p>In these reactions aryl iodides have been used in most cases. However, less reactive aryl triflate, chloride and bromides were activated using tetrabutylammonium iodide.</p><p>The reactivities of nucleophiles may have influence on the radiochemical yield of the <sup>11</sup>Clabelled compounds. Carboxyamination of aryl ha

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35

Larsson, Michael. "Natural products from nonracemie building blocks : synthesis of pine sawfly pheromones." Doctoral thesis, KTH, Kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128.

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This thesis describes a number of synthetic approaches for obtaining chiral, enantiomerically pure natural products, in particular some semiochemicals. This has been accomplished by using various strategies; by starting from compounds from the chiral pool, by using chiral auxiliaries, via enzymatic resolutions or by chemical asymmetric synthesis. Hence, the sexual pheromone of Microdiprion pallipes, a propanoate ester of one or several isomers of 3,7,11-trimethyltridecan-2-ol, was synthesised, both as a mixture of all isomers and as the sixteen pure, individual stereoisomers. These compounds w

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36

Sebelius, Sara. "Palladium-Catalyzed Synthesis and Transformation of Organoboranes." Doctoral thesis, Stockholm : Department of Organic Chemistry, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1198.

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Desai, Bimbisar. "Microwave assisted organic synthesis." Thesis, University of Surrey, 2002. http://epubs.surrey.ac.uk/842821/.

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The area of chemical research and synthesis increasingly recognises the need for improved technologies and methods, which involves chemical processes with less energy consumption, time savings, reduction and/or minimisation of waste, simple processes and an overall clean production. Microwave heating has been exploited in a variety of disciplines for many useful applications and organic synthesis is an area, which has benefited significantly over the past decade. The present study investigates organic reactions accelerated under microwave irradiations. In particular, the study involves use of

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Sarkar, Achintya Kumar. "Allylsilanes in organic synthesis." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292242.

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Hetherington, Peter. "Organic synthesis with bromonitromethane." Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317552.

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Short, Robert Paul 1951. "Organoboranes in organic synthesis." Thesis, Massachusetts Institute of Technology, 1989. http://hdl.handle.net/1721.1/14204.

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O'Rourke, Christopher. "Photocatalysis for organic synthesis." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675420.

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A wide range of commercially available self-cleaning materials/products are now available, from architectural materials, such as; glass, paint, plastics, and concrete, to water and air purification systems. These products exploit the destructive oxidative nature of SPC to purify air and water. In contrast, this thesis introduces the less well studied use of SPC to mediate the synthesis of a range of useful organic species, and aims to develop a fast screening process for monitoring such reactions to aid future developments in SPC mediated organic synthesis. It is demonstrated that NMR is a ver

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42

Wångsell, Fredrik. "Design and Synthesis of Serine and Aspartic Protease Inhibitors." Licentiate thesis, Linköping University, Linköping University, Organic Chemistry, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7372.

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<p>This thesis describes the design and synthesis of compounds that are</p><p>intended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. The NS3 protease, encoded by HCV, is essential for replication of the virus and has become one of the main targets when developing drugs to fight HCV. The inhibitors discussed here constitute surrogates for the widely used <em>N</em>-acyl-hydroxyproline isos

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Mitra, Soumya. "Total synthesis of gomisin O asymmetric total syntheses of eupomatilones 1, 2 and 5; and studies towards total synthesis of mayolide A /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189449580.

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Nimkar, Sandeep Krishnaji. "Studies in asymmetric synthesis: Development of new synthetic methods for syntheses of natural products." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186538.

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The research, to be discussed in three chapters, involves the development of new synthetic methods which are applicable to the total synthesis of many natural products. Chapter 1: As a part of a program to synthesize new auxiliary agents for asymmetric synthesis, we have prepared a structurally rigid acetal from norbornene in three chemical steps. This enantiomerically pure acetal has been used for resolution of racemic α-hydroxy esters and might be applied as a chiral auxiliary for diastereoselective reactions. Chapter 2: The Calicheamicin and Esperamicin antibiotics have shown remarkable bio

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Pirovano, V. "GOLD-CATALYZED SYNTHESIS AND FUNCTIONALIZATION OF HETEROARENES." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/232413.

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This work of thesis describes the results obtained from the study of gold-catalyzed synthesis or functionalization reactions or heteroarenes. The work is presented in four different chapters. The first chapter summarizes the most representative reactivity trends in the field of gold catalysis and serves as general introduction. The second chapter is focused on the cycloaddition reaction of 2-vinylindoles with enones towards the preparation of tetrahydrocarbazole derivatives. This process has been studies using classic Lewis acids and gold complexes as catalysts. According to the results, gol

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Saarinen, Gabrielle. "Development of Synthetic Routes for Preparation of 2,6-Disubstituted Spiro[3.3]heptanes." Thesis, Mälardalen University, School of Sustainable Development of Society and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-6027.

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<p>2,6-Disubstituted spiro[3.3]heptanes were synthesized to investigate and develop synthetic methods for preparation of these compounds. Possibilities for introducing different functionalities like nitriles and sulfonamides were also investigated.</p><p> </p><p>Synthetic routes presented describe successive [2+2] cycloadditions between dichloroketene and olefins to give the sought after spiro compounds with low to moderate yields throughout the multi-step synthesis. [2+2] Cycloadditions offered low turnovers and chromatography was required for purification.</p><p> </p><p>A synthetic route wit

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47

Modin, Stefan. "Developments in the Field of Aza-Diels-Alder Reactions, Catalytic Michael Additions and Automated Synthesis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, Univ.bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4640.

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48

Saito, Yu. "Synthesis of bioactive compounds: Synthetic study of D-Lac-terminated peptidoglycan fragment structures." Thesis, KTH, Kemiteknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-300085.

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Peptidoglycan (PGN) är en bakteriecellväggskomponent och känd för att känna igen olika receptorer eller enzymer för att leda aktiveringsimmunsystemet. Den allmänna strukturen för PGN består av sockerkedjor inklusive N-acetylglutamin (GlcNAc), N-acetylmuraminsyra (MurNAc) och tvärbundna peptidkedjor. PGN-fragment med D-Lac-ändpeptider har hittats från vankomycinresistenta enterokocker men ett kemiskt syntetiserat PGN-fragment med en D-Lac-ändpeptid har inte undersökts i detalj. Således fokuserade vi på syntesen av PGN-fragmentstrukturer som inkluderar en D-Ala-D-Lac-rest vid den terminala delen

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49

Alibhai, Najma. "Part A. The syntheses of dillapiol and its 4-thio derivatives, Part B. The synthesis of trichiliasterone B." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/MQ48124.pdf.

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50

Mojica, Mike. "Investigation of new synthetic reactions: the synthesis of hydrazines via the Aza-Lossen rearrangement, the synthesis of carbamoyl azides from amines, and deprotection reactions using water at elevated temperatures." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51791.

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This thesis explores three rare synthetic routes: the synthesis of hydrazines via the aza-Lossen rearrangement, the synthesis of carbamoyl azides from amines, and deprotection reactions using water at elevated temperatures. The aza-Lossen reaction was found to be ideal at “infinite dilution” conditions and could be performed with both aryl and alkyl example. Carbamoyl azides could be synthesized in high yields from both aryl and alkyl amines. The carbamoyl azide reaction was found to be much more efficient with Cs (+1) present. Lastly, water at elevated temperatures conditions was efficient at

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