Dissertations / Theses: 'Organization of production activity'

1

Акопян, Г. А. "Забезпечення ефективності господарської діяльності підприємства в умовах ринку (на прикладі ТОВ «Поліський хліб»)." Thesis, Чернігів, 2020. http://ir.stu.cn.ua/123456789/19960.

Full text

Abstract:

Акопян, Г. А. Забезпечення ефективності господарської діяльності підприємства в умовах ринку (на прикладі тов «Поліський хліб» : магістерська робота : 073 Менеджмент / Г. А. Акопян; керівник роботи Дука А. П. ; Національний університет «Чернігівська політехніка», кафедрапублічного управління та менеджменту організацій. – Чернігів, 2020. – 74 с.
Робота присвячена теоретичним та практичним аспектам розкриття сутності ефективності господарської діяльності підприємства, а також забезпечення досягнення такої ефективності в умовах ринку (на прикладі ТОВ «Поліський хліб»). Робота складається з трьох розділів, вступу та висновків. У вступі обґрунтовується актуальність теми, мета і завдання дипломної роботи. У першому розділі розкриті теоретичні основи поняття ефективності, висвітлені питання з підвищення ефективності виробничої діяльності підприємства. Розглянуто систему заходів планування для підвищення ефективності. У другому розділі розглянуто аналіз діяльності об’єкта досліджень, який базується на вивченні діяльності підприємства. У цьому розділі міститься техніко-економічна характеристика підприємства, аналіз асортименту продукції, розглядається стан активів підприємства. Для оцінки ефективності розраховано показники платоспроможності, рентабельності, ліквідності та фінансової стійкості підприємства. Третій розділ містить пропозиції щодо підвищення ефективності виробничої діяльності шляхом введення в експлуатацію нового обладнання. У висновках містяться узагальнення проблем підприємства, заходів щодо вирішення проблем діяльності підприємства.
The work is devoted to the theoretical and practical aspects of revealing the essence of the efficiency of economic activity of the enterprise, as well as ensuring the achievement of such efficiency in market conditions (for example, LLC "Polish bread"). The work consists of three sections, introduction and conclusions. The introduction substantiates the relevance of the topic, purpose and objectives of the thesis. The first section reveals the theoretical foundations of the concept of efficiency, highlights the issues of improving the efficiency of production activities of the enterprise. The system of planning measures for efficiency increase is considered. The second section discusses the analysis of the research object, which is based on the study of the enterprise. This section contains the technical and economic characteristics of the enterprise, analysis of the product range, considers the state of the assets of the enterprise. To assess the effectiveness of the indicators of solvency, profitability, liquidity and financial stability of the enterprise. The third section contains proposals for improving the efficiency of production activities by putting new equipment into operation. The conclusions contain generalizations of the problems of the enterprise, measures to solve the problems of the enterprise.

APA, Harvard, Vancouver, ISO, and other styles

2

Herashchenko, Irina Alekseevna. "Modern forms of production organization." Thesis, Національний технічний університет "Харківський політехнічний інститут", 2017. http://repository.kpi.kharkov.ua/handle/KhPI-Press/44531.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Spence, Frank W. "Activity-based costing in a service organization." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1993. http://handle.dtic.mil/100.2/ADA268706.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Hatcher, Melanie J. "Activity patterns and organization within ant nests." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332313.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Koivu, Timothy Grant. "Production activity control, the hierarchical production control policy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq21093.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Rønning, Marte. "Studies in Educational Production and Organization." Doctoral thesis, Norwegian University of Science and Technology, Department of Economics, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-1959.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Базик, Ю. О. "Удосконалення організації надання послуг у сфері лікувально-оздоровчого туризму (на прикладі санаторію «Куяльник»)." Thesis, Одеський національний економічний університет, 2021. http://local.lib/diploma/Bazyk.pdf.

Full text

Abstract:

У роботі розглянуто сутність та особливості розвитку лікувально-оздоровчого туризму; досліджено комплекс послуг, надаваних закладами санаторно-курортного профілю; вивчено світовий та вітчизняний досвід організації лікувально-оздоровчого туризму. В аналітичній частині розглянуто організаційно-економічну характеристику діяльності санаторію «Куяльник»; досліджено комплекс послуг, надаваних у цьому санаторії; зроблено аналіз динаміки виробничо-економічної діяльності санаторію «Куяльник». Внесені пропозиції, спрямовані на вдосконалення організації надання послуг в санаторії «Куяльник». Зроблено економічне обґрунтування впровадження пропонованих заходів.
The essence and features of development of medical and health tourism are considered in the work; the complex of services provided by establishments of sanatorium-resort profile is investigated; the world and domestic experience of the organization of medical and improving tourism is studied. In the analytical part the organizational and economic characteristic of activity of sanatorium «Kuyalnik» is considered; the complex of services provided in this sanatorium is investigated; the analysis of dynamics of production and economic activity of sanatorium «Kuyalnik» is made. Proposals were made to improve the organization of services in the sanatorium «Kuyalnik». The economic substantiation of implementation of the offered measures is made.

APA, Harvard, Vancouver, ISO, and other styles

8

Петрушенко, Юрій Миколайович, Юрий Николаевич Петрушенко, and Yurii Mykolaiovych Petrushenko. "Cultural embeddedness of production activity." Thesis, Видавництво СумДУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/8340.

Full text

Abstract:

Most scientists don’t doubt the accepted in social explorations hypothesis that business relations influence ideas and outlook of people. However much less people state the reverse is also true – various cultural aspects form industrial institutions and processes. To the point of view of Amitai Etzion, a founder of the Society for the Advancement of Socio-Economics (SASE), this direction of scientific research is quite promising in terms of findings to explain numerous globalization and transformation processes. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/8340

APA, Harvard, Vancouver, ISO, and other styles

9

Holliday, Ruth. "Small firms and the organization of production." Thesis, Staffordshire University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333605.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Clos, Clémence. "Des démarches de DD/RSE à la dégradation du rapport social de travail dans le secteur hôtelier." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC259.

Full text

Abstract:

Cette thèse s’intéresse à la manière dont des discours et des pratiques mis sous l’égide de la Responsabilité Sociale des Entreprises (RSE) et du Développement Durable (DD) se structurent dans le secteur hôtelier, en rendant compte de la façon dont ils participent à la dégradation du rapport social de travail. En proposant le concept intermédiaire de démarches DD/RSE pour qualifier l’ensemble de ces discours et pratiques, nous caractérisons ces démarches pour montrer qu’elles sont construites à partir d’une articulation avec les stratégies de profit de chacun des deux modèles productifs qui s’imposent, en l’occurrence les hôtels de luxe et les hôtels de chaînes intégrées. Incarnant de nouvelles stratégies de différenciation, elles participent au processus de sectorisation et renforcent les stratégies de domination intra-sectorielle. La construction de ces démarches dans les hôtels de luxe se fait par externalisation, quand elle se fait par intégration au processus de production dans les chaînes. Les démarches DD/RSE y sont standardisées à travers un modèle industriel de production. Il ressort de cette analyse que la manière dont ces hôtels intègrent les démarches participe de la dégradation du rapport social de travail. Telles qu’elles sont construites, les démarches de DD/RSE renforcent la division technique et genrée du travail, participant à l’intensification du travail et au renouvellement des stratégies de mobilisation et de mise au travail des salariés
This thesis analyses the practices built from the Corporate Social Responsibility (CSR) and the Sustainable Development (SD) and the way they transform the French hospitality industry. We propose an intermediate concept of SD/CSR efforts to qualify all these speeches and practices. This thesis first characterizes these efforts to show that they are the result of successful and powerful actors strategies in the industry, the luxe hotels and hotel which belong to chain. Embodying new differentiation strategies, it makes this two hotel type stronger and participates to the process of sectorization by strengthens the sectorial processus. The insertion of SD/CSR efforts in luxury hotels is made by outsourcing, whereas the hotels which belong to chains integrate it into their process of production. They standardize SD/CSR efforts through an industrial model of production. We prove that the way these hotels integrate the SD/CSR participates of the degradation of the wage labor nexus, particularly regarding the working conditions and the forms of mobilization of the employees. We also demonstrate that such as they are built, the SD/CSR efforts as instruments in the service of the corporate strategy, strengthen the technical division and gendered of labor, participate in the intensification labor, and they give to mobilization speeches a revival with the idea or nature protection

APA, Harvard, Vancouver, ISO, and other styles

11

Rhodes, Christopher. "Political Christianity: Internal Organization, Preferences and Church Political Activity." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226091.

Full text

Abstract:

This dissertation examines the role of internal structure of religious organizations in influencing these organizations’ interactions with incumbent governments and ultimately determining the political activities of religious groups. This dissertation fits within a body of literature known as the political economy of religion. I expand upon this literature by examining religious groups in terms of internal organization, focusing on Christian churches in Africa, with Kenya as my primary case country. The central argument of this dissertation is that churches (national-level denominations) with certain organizational features – centralized leadership, authoritarian decision-making procedures, and lack of internal accountability mechanisms – are more likely to have friendlier interactions with governments and therefore tend to adopt more pro-government political stances compared to churches that lack these features. This relationship operates through two mechanisms. First, centralized churches possess negotiation advantages over decentralized churches. Second, centralized, authoritarian churches can more easily be co-opted by incumbent governments. The dissertation also expand upon existing literature by offering a fuller and more nuanced understanding of the preferences of governments and churches vis-à-vis one another, proposing that churches seek to maximize number of church members, member faithfulness, and resources, while governments seek ideological support, citizen mobilization, and social service provision from churches. These arguments are examined by historical comparative case studies of five of the largest Christian denominations in Kenya over the course of the country’s first three post-independence presidents. Through qualitative historical analysis, combined with information gathered through fieldwork in Kenya, the dissertation demonstrates how the preferences of these churches and governments, mediated through the internal organizations of the churches, influenced church-state relations and ultimately determined the churches’ political stances. The impact of internal organization is greater than factors such as ethnicity or theological conservatism/liberalism. The dissertation tests these arguments through a quantitative analysis of church political orientation using national-level data on Christian churches and countries across Africa from independence through 2010. The results of the statistical analyses show significant effects of organizational features such as centralization, consistent with the arguments made concerning Kenya. The dissertation then gives brief qualitative analysis of church-state relations for several of the African churches included in the quantitative dataset.

APA, Harvard, Vancouver, ISO, and other styles

12

Carlsson, Anders, and Henrik Fredriksson. "Production Organization at Husqvarna AB : A Study of Chainsaw Production at Three Factories." Thesis, Jönköping University, JIBS, Economics, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-1520.

Full text

Abstract:

This bachelor thesis looks at the organization of the production of chainsaws in three different Husqvarna AB plants; one in Sweden, one in Brazil and one in the USA. The field of production organization carries the mark of men like Adam Smith, Frederick Taylor and Henry Ford, and it is with reference to the approaches of these men, and others, that we ask how Husqvarna AB organizes its production of chainsaws.

We found that production in the Swedish plant consisted of a worker philosophy influenced by the “group thinking” that was prominent in Sweden in the 1970s, coupled with a production philosophy sharing many traits with Ford’s mass production while incorporating elements of lean production. The production lines in Brazil are identical to the newer lines in the Swedish plant. The differences are fewer influences from “group” approaches such as the socio-technical view. The US plant provides a sharp contrast to the other two. It produces saws for the consumer market and not the professional market. Quality and longevity demands are radically different, which enables for another production approach to be used. With simple operations and very short times at each work station, the US plant is not many steps away from Ford’s mass production approach.

Denna kandidatuppsats studerar produktionsorganisationen inom Husqvarna AB:s motorsågstillverkning i tre olika fabriker; en i Sverige, en i Brasilien och en i USA. Området produktionsorganisation är influerat av män som Adam Smith, Frederick Taylor och Henry Ford, och det är i ljuset av bland annat dessas bidrag som vi frågar oss hur Huskvarna organiserar sin produktion.

Vi fann att den svenska fabriken var en kombination mellan ”grupptänkandet” som aktualiserades i Sverige på 1970-talet, särskilt med avseende på arbetarna, och ett produktionssätt som i många delar är massproduktion av Fordiskt snitt som allt mer går emot lean production. De brasilianska produktionsbanorna är identiska med de nyare svenska. Skillnaderna ligger i arbetarnas roller, då den brasilianska fabriken bär färre tecken på att vara inspirerat av grupptänkandet i till exempel det socio-tekniska synsättet. Den amerikanska fabriken står i skarp kontrast till de övriga två. Den producerar för konsumentmarknaden och inte för den professionella marknaden. Lägre kvalitets- och livslängdskrav tillåter ett annat produktionssätt. Den amerikanska fabriken har många likheter med Fordisk massproduktion, med enkla handgrepp och mycket korta tider vid varje station.

APA, Harvard, Vancouver, ISO, and other styles

13

Liu, Huizhong. "Essays on production and investment." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6980.

Full text

Abstract:

This dissertation contributes to the understanding of production and investment decisions under different circumstances. Specifically, it focuses on two aspects: (1) in a market with financial frictions, how entrepreneurs choose their production sectors and finance their business; (2) in a market with spillovers in research and development (R&D), how spillover effect influences firms' R&D investment and other market performances. In Chapter 1, I examine how financial frictions affect occupational shifts and structural transformations between the service sector and the manufacturing sector. I construct a general equilibrium occupational choice model with intermediation costs and contract enforcement, in which agents can choose to be entrepreneurs in the service or manufacturing sectors, or to be workers. The model is calibrated to match Chinese statistics and is used to conduct policy experiments that vary intermediation and enforcement costs. I find that high intermediation costs cause the contribution to output and the number of workers employed in the service sector to increase. They also decrease output per capita in the service sector. The service sector size and enforcement do not have a monotonic relationship; the association is positive when enforcement cost is sufficiently high and it is negative when enforcement cost is sufficiently low. Counterfactual experiments are performed for the U.S., Brazil and the Philippines. I find that intermediation costs and enforcement can explain almost half of the sector size gap with Brazil and the Philippines. In Chapter 2, we consider a one-stage Cournot duopoly of R&D. We characterize the Nash equilibrium of the one-stage game and provide a comparison with the two-stage version of the same Cournot model of R&D/product market competition. We look at R&D expenditures, profits, output, and welfare. Under perfect symmetry, the one-stage model always leads to higher profits when the spillover parameter is not equal to 1/2. Moreover, the one-stage model implies more R&D expenditure and higher welfare if and only if the spillover parameter is greater than 1/2. In Chapter 3, we consider a one-stage Cournot duopoly with R&D and spillovers in R&D inputs and makes a comparison with the two-stage game version where R&D levels are observed before the output choices. We focus on the possibility of a prisoner's dilemma in R&D. By adding an initial period to our one-stage model, wherein firms decide whether or not to conduct R&D, we find that there is no prisoner's dilemma in R&D regardless of the level of spillover effects.

APA, Harvard, Vancouver, ISO, and other styles

14

SHAVER, KAY A. "Activity-based Evaluation of Operations Management within Service Operations Organization." NCSU, 1998. http://www.lib.ncsu.edu/theses/available/etd-19980408-101235.

Full text

Abstract:

SHAVER, KAY ALBRIGHT. Activity-based Evaluation of Operations Management within Service Operations Organization. (Under the direction of John Dutton.) The purpose of this study is to use historical cross-sectional data including order characteristics to predict the time requirements of the indirect activity of managing. The subject of the study is the Operations Manager, who manages the supervision of engineering and installation of orders. Predictions of time estimates for the Operations Manager will provide information for staffing and workforce planning of the indirect activities required to manage the forecasted order workload. The research includes a pilot survey of Operations Managers in three regions and a final empirical study, which includes the entire Service Organization?s Operations Manager population. Using regression analysis, the study evaluates the factors noted in the pilot survey as important to the Operations Managers. Consideration is given to order characteristics, such as size, customer relationships, schedule changes, interval, Operations Manager assigned. Consideration is also given to general characteristics, such as seasonal effects, concurrent orders, experienced installers available, and inventory levels. The analysis reveals that category of work, size of the order as measured by number of frames, seasonal impacts, the Operations Manager assigned, customer relationships, and the effort required to underspend the budget are key predictors of the time required to manage the supervision of the engineering and installation of orders. The results indicate interval, inventory, schedule changes and experienced installers available are not significant indicators of this indirect order activity.

APA, Harvard, Vancouver, ISO, and other styles

15

Hsieh, David. "Organization and role of international collaboration in research production." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/281178.

Full text

Abstract:

A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
The prevalence of multi-national and cross-disciplinary collaborative in the production of knowledge defines modern science as a social enterprise that extends beyond political, social, and geographic boundaries. The purpose of this study was to assess global trends in the composition and impact of multinational research teams. By examining the bibliometric data of 3.7 million primary research articles published from 1975 to 2005, it was ascertained that the frequency and scale of international collaborations has increased globally. Of note, the publications of many countries associated with lower research output were more often consistently affiliated with other nations across the time frame studied. By analyzing the number of times a publication is cited, it was discovered that multinational research studies have a greater research impact than research without an international presence, although the number of affiliated nations does not strictly correlate with citations. Taken together, this study provides insight into the dynamics of research teams which may better inform us how scientific partnerships between countries may be fostered and which collaborations may be advantageous.

APA, Harvard, Vancouver, ISO, and other styles

16

Khouja, Ahmad Yassin. "Mechanisms of prostanoid production : regulation of phospholipase activity." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335838.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Kerr, Kirk W. "Competitive Effects of Vertical Restraints and Promotional Activity." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1211990754.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Ferreira, Bruno Domingos. "Self-organization and complexity theory to support evolvable production systems." Master's thesis, FCT - UNL, 2009. http://hdl.handle.net/10362/2056.

Full text

Abstract:

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Engenharia Electrotécnica e de Computadores
De forma a tornar os sistemas de produção evolutivos uma realidade, devem ser elaboradas formas de implementar capacidades de auto-organização. Os sistemas de produção evolutivos são compostos por módulos do sistema agentificados, os quais necessitam de interagir e colaborar entre eles. A aproximação de “Plug&Play” significa que a reprogramação desses módulos face às possíveis alterações deve ser evitada. Em vez disso os agentes organizar-se-ão entre eles de forma a conseguirem responder a todas as acções de montagem solicitadas. Para tal os agentes necessitam de conhecer informação sobre o módulo que representam: funcionalidades, geometrias, dimensões, interfaces, limitações, entre outras. Também as partes que irão compor o produto final, as instruções de montagem, e os processos, devem ser definidos de uma forma abstracta e genérica para que o sistema tenha o máximo de liberdade para se auto-reconfigurar em caso de necessidade. Esta tese visa mostrar como é que se pode definir as características sobre os módulos de uma forma genérica, e que possam facilmente ser interpretadas pelo computador ou pelo utilizador. Por fim serão mostradas e detalhadas as interacções que mostram como é que a auto-organização surge.

APA, Harvard, Vancouver, ISO, and other styles

19

Stain, Christopher John. "The vascular cambium : establishment, activity and woody biomass production." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397840.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Jaffe, Stephen R. P. "Metabolic engineering for increased electrogenic activity and bioenergy production." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/8069/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Chandregowda, Adithya. "Neurophysiological Activity Related to Speech Production: An ERP Investigation." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5919.

Full text

Abstract:

The event related potential (ERP) technique is enjoying widespread application in neurophysiological research due to its fine temporal resolution. Of relevance to this study are ERPs related to voluntary movements. The precision with which movement related processes could be recorded using the ERP technique was demonstrated by Gilden, Vaughan and Costa (1966) and Kutas and Donchin (1974, 1977, and 1980) who found that the readiness potential (RP) immediately preceding hand movement was larger over the hemisphere contralateral to the responding hand. Given that left hemisphere controls right hand movements and vice versa, their findings confirmed that the lateralized readiness potential (LRP) is an index of motor preparation. It has been well established that electrodes from the left precentral site (C3) and from the right precentral site (C4) can capture LRPs, and that the motor cortex is the major generator of this component. In the speech domain, researchers recording ERPs related to motor preparation have often considered pre-determined electrode sites (e.g., F3, F4, C3, C4, Cz) assuming that their proximity to motor areas on the cortex enables capturing of specific activity from those areas [F3 close to Broca’s area, Cz close to Supplementary motor area (SMA), C3 to left motor strip, C4 to right motor strip]. A consistent finding has been that the RP preceding speech is greatest at the central electrode sites, which has been attributed to SMA and motor cortex activity. Studying speech production related ERPs at predetermined set of electrodes might not suffice for two reasons: (1) unlike simple finger movement, speaking is a fine motor skill requiring coordination of multiple systems (e.g., respiratory system, phonatory system, articulatory system) and muscles, and (2) the far-field nature of the ERP recording technique often results in spatial and temporal overlap of components. To overcome these challenges, this study considered multichannel recordings and principal component analysis (PCA). Twenty three healthy participants completed a simple hand motor task (pressing a button with the right index finger and another button using the left index finger based on the color of a stimulus frame displayed on a computer screen), and a speech task (saying “pool” or withholding the response based on the color of the frame). The purpose of including a hand motor task was to verify that neural activity specific to motor preparation was detectable in participants when a well-established condition for the elicitation of LRPs was utilized. Both stimulus-locked and response-locked ERPs from 21 right handed participants (11 females and 10 males) were studied. Interhemispheric difference wave analysis and PCA revealed left hemisphere lateralization of the potential (i.e., the LRP) immediately preceding right hand movements, similar to previous studies. The LRP specific to left hand movements (non-dominant hand), however, showed bihemispheric distribution. Results from the speech motor task confirmed that overlapping components affect interpretation of ERPs related to speech production if just central electrode sites are considered. Two ERP components emerged from the multichannel PCA as distinguishing between the speaking and no speaking condition: a posterior negative component and a left lateralized positive component. The morphology of the posterior negative component and significant moderate correlation of its amplitude with the mean reaction time suggest that this component is a possible index of speech motor preparation. Further research is required to determine whether the left-lateralized component reflects a process mediated by the speech dominant hemisphere (left). In addition to demonstrating the usefulness of multichannel recordings and PCA in ERP investigations, the study provides several methodological guidelines for capturing ERPs related to speech production.

APA, Harvard, Vancouver, ISO, and other styles

22

Pérez, Arnaez Rafael. "DAISY book production at the National Organization of the Blind (ONCE)." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-68672.

Full text

Abstract:

DAISY book production at the ONCE, with the digitization and subsequent reformatting of our stacks to the DAISY standard, has pursued two key objectives: to digitize our collection as quickly and efficiently as possible and to lower the production costs of digital talking books in DAISY format. This discussion describes the highlights of that process.

APA, Harvard, Vancouver, ISO, and other styles

23

Harhoff, Dietmar. "Strategic spillover production, vertical organization, and incentives for research and development." Thesis, Massachusetts Institute of Technology, 1991. http://hdl.handle.net/1721.1/13950.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Pérez, Arnaez Rafael. "DAISY book production at the National Organization of the Blind (ONCE)." Deutsche Zentralbibliothek für Blinde Leipzig (DZB), 2010. https://slub.qucosa.de/id/qucosa%3A1144.

Full text

Abstract:

DAISY book production at the ONCE, with the digitization and subsequent reformatting of our stacks to the DAISY standard, has pursued two key objectives: to digitize our collection as quickly and efficiently as possible and to lower the production costs of digital talking books in DAISY format. This discussion describes the highlights of that process.

APA, Harvard, Vancouver, ISO, and other styles

25

Masai, Pierre. "Modeling the lean organization as a complex system." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAD029/document.

Full text

Abstract:

Dans cette thèse, après avoir expliqué l'historique et les concepts principaux de l’organisation lean dans différents contextes, le monde des systèmes complexes est exploré, puis il est montré pourquoi le lean est lui-même un système complexe. Un modèle novateur du lean est proposé sous forme d'ontologie, le Lean Organization Framework (LOF), qui peut être appliqué à toutes les formes d’organisations. Le LOF est testé avec celles qui ont déjà été explorées, proposant ainsi des pistes d’amélioration (lean pour la fabrication, pour l’IT, pour les soins de santé, pour la fonction publique, pour les organisations non gouvernementales, pour les start-ups et pour l’éducation). Il peut également être appliqué à de nouveaux domaines d’activités avec l’aide d’experts dans ces domaines, une approche montrée avec les exemples nouveaux d’une fondation lean et de l’architecture d’entreprise lean (Lean EA) mais aussi en comparant l’organisation lean au système immunitaire, un exemple bien connu de système complexe. Ensuite, un modèle de processus lean est proposé, présentant les propriétés émergentes d’un système complexe, le hoshin kanri (gestion des objectifs de l’organisation), y compris dans sa dimension culturelle. Les résultats de son expérimentation pratique avec l’application eHoshin sont discutés et un premier prototype en open source est présenté, déjà utilisé à ce jour par une centaine d’organisations dans le monde. Une seconde expérimentation plus robuste dans l’industrie (Toyota, dans plusieurs fonctions et entités juridiques) est exposée. Le modèle théorique est enfin amélioré sur base des résultats obtenus. En annexe, les concepts du lean sont expliqués avec leur application à six domaines de connaissance différents et les programmes de simulations sont listés
In this thesis, after explaining the history and main concepts of the lean organization in various contexts, the world of complex systems is explored, then it is shown why the lean organization is itself a Complex System. A novel model of lean is proposed as an ontology, the Lean Organization Framework (LOF), which can be applied to all forms of organizations. The LOF is tested with those already explored (Lean Manufacturing, Lean IT, Lean Healthcare, Lean Government, Lean NGO, Lean Start-Up, Lean Education) and proposes ways to enhance them. It can also be applied to new domains with the help of subject matter experts, an approach that is checked with the novel cases of a Lean Foundation and Lean Enterprise Architecture (Lean EA), but also with the comparison of the lean organization with the immune system, a well-known Complex System example. Then, a model of lean process presenting the emergent properties of a Complex System is proposed: the hoshin kanri, or management of the organization objectives, including in its cultural dimension. The results of its practical implementation with the eHoshin application are discussed and a first open source prototype already used by around one hundred organizations in the world is explained. A second, more robust implementation in the industry is presented (at Toyota, extended to several departments and legal entities). Finally, the theoretical model is improved based on the experimentation results. In the appendices, the lean concepts are explained together with their application to six domains of knowledge and the simulation programs are listed

APA, Harvard, Vancouver, ISO, and other styles

26

Ng, Wai-yun Louisa. "Production of variants of mitogillin with reduced IgE binding activity." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972093.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Jia, Wei. "The production of high specific activity radionuclides for radiotherapy application /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9720538.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Raley, Gabrielle. "Between art and advertising the production, organization, and culture of commercial art /." Diss., Restricted to subscribing institutions, 2010. http://proquest.umi.com/pqdweb?did=2023816031&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Fülle, Gunnar. "The organization of mass production of terra sigillata in the Roman Empire." Thesis, University of Oxford, 2000. http://ora.ox.ac.uk/objects/uuid:130e6711-89fe-4d1a-a63f-2660ed97ad75.

Full text

Abstract:

Results of research on the production and distribution of terra sigillata are frequently used as weighty arguments in the discussion of the character of the Roman economy as a whole. Still, many substantial problems remain under discussion, among them the important question of how the mass production of this ware was organized. By re-examining and combining evidence from various production centres, the present thesis aims to develop a comprehensive model for the organization of terra sigillata production. It employs comparative and complementary approaches to interpret the archaeological and epigraphical material, and also analyzes the underlying social and legal structures. Theoretical conceptions of the organization of pottery production are dealt with, and the role of terra sigillata production in models of ancient economy is discussed. The principal focus of the study is on some of the most important centres of terra sigillata production in Italy, Gaul, Germany, Spain, and Africa. Although each production centre has its own individual features, common ones prevail. The application of producers' signatures can be explained by the joint use of production facilities, especially drying sheds, and the exchange of moulds. Similarities in the use of signatures are interpreted as indicating similarities in the organization of production, whereas irregularities in their application are looked upon as the result of varying production conditions. The interpretation of the potters' graffiti enables us to postulate the existence of a leasehold system in which the lessor entered into contracts with lessee workshop managers to deliver set numbers of vessels. Firing masters, who were potters themselves and responsible for the operation of the kilns, acted as middlemen or directly on behalf of the lessor, approving and controlling the potters' work. The mode of production in all centres appears to have been a nucleated workshop industry rather than a manufactory, based on a leasehold system and regulated by large-scale traders, with the producers' social status being of little relevance. Thus all arguments founded upon the distinction of Italian slave manufactories and cooperative production of free men in the western provinces are no longer plausible.

APA, Harvard, Vancouver, ISO, and other styles

30

Loveman, G. (Gary). "Changes in the organization of production and the skill composition of employment." Thesis, Massachusetts Institute of Technology, 1989. http://hdl.handle.net/1721.1/37988.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

SoÃŒ?derquist, Klas Eric David. "Inside the tier model : product development organization and strategies in automotive supplier firms." Thesis, Henley Business School, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363521.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

DeLessio, Mark Philip. "Assessing the complex product design process planning activity." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610229.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Leung, Lai-yue Ciris, and 梁麗榆. "The social organization of a Cantonese opera performance." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B29751093.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

SEETHARAMAN, SUMATHI. "SELF-ORGANIZED SCHEDULING OF NODE ACTIVITY IN LARGE-SCALE SENSOR NETWORKS." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1092939502.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Schneider, Peter. "Source activity and tonotopic organization of the auditory cortex in musicians and non-musicians." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961907436.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Kolahi-Ahari, Ali. "A study of superoxide dismutase activity and superoxide production in kiwifruit." Thesis, University of Canterbury. Biological Sciences, 2006. http://hdl.handle.net/10092/1343.

Full text

Abstract:

The activity of superoxide dismutase (SOD) was determined in three kiwifruit (Actinidia) species including A. deliciosa, A. chinensis, and A. arguta. Among the species tested, the highest SOD activity was found in crude extracts prepared from fruit tissues of A. deliciosa. The highest enzyme activity was localized in seed, followed by locules, core and outer pericarp (OP). SOD activity in crude extract of whole fruit remained stable for at least one month when stored at -20℃. The effect of synthetic protease inhibitors (PI) on SOD activity was investigated. Supplementing crude kiwifruit extracts with PI improved SOD activity in freshly prepared extracts, and in extracts stored at 4℃, but had no effect on those stored at -20℃. Among the PI used, iodoacetamide (an inhibitor of cysteine proteases, for example, actinidin which is a principal protease found in kiwifruit) and PMSF (an inhibitor of serine proteases), had the most and least influence on SOD activity in crude kiwifruit extracts, respectively. There was a significant increase in SOD activity in kiwifruit (that were relatively firm) when the fruits were stored at low temperature (4℃). An increase in SOD activity was also correlated with a decrease in fruit firmness. Staining fruit tissues with nitroblue tetrazolium (NBT) provided evidence for stress-induced superoxide generation in kiwifruit tissues. Taken together, the changes in SOD activity and the capacity for stress-inducible superoxide production in post-harvest kiwifruit suggest that SOD might play a fundamental role in the storage life/ripening of kiwifruit.

APA, Harvard, Vancouver, ISO, and other styles

37

Tulah, Asif. "The genetics of LTB4 production and activity in asthma and COPD." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546523.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Kwakye-Awuah, Bright. "Production of silver-loaded zeolites and investigation of their antimicrobial activity." Thesis, University of Wolverhampton, 2008. http://hdl.handle.net/2436/57733.

Full text

Abstract:

The production of silver-loaded zeolites either by ion exchange method or by isomorphous substitution of silver ions into zeolites frameworks and their antimicrobial activity is presented. Silver-loaded zeolites produced by ion-exchange in this work include silver-exchanged zeolite X, silver-exchanged zeolite A and silver-exchanged high-alumina Phillipsite. Silver-doped Analcime was produced by isomorphous substitution of silver ions into the Analcime framework. The silver-loaded zeolites were characterized by X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, particle size analysis and Fourier transformed infrared (FTIR) spectroscopy. Studies showed that the amount of silver ions loaded into the zeolites frameworks differed for each zeolite. XRD analysis showed little or no changes in the phase purity of all zeolites before and after ion exchange or before and after substitution of silver ions. SEM analysis and particle size analysis showed that the morphology of each zeolite particles was closely related before and after ion exchanged or before and after substitution of silver ions. The antimicrobial activity of these silver-loaded zeolites was investigated by exposing Escherichia coli K12W-T, Staphylococcus aureus NCIMB6571 and Pseudomonas aeruginosa NCIMB8295 suspended in tryptone soya broth (TSB) to the silver-loaded zeolites. The first stage of the investigation involved the exposure of the strains to silver-loaded zeolites in TSB for a duration of 24 hours at different concentration of silver-loaded zeolites. The second stage involved the exposure of the strains to silver-loaded zeolites in TSB over a period of two hours. The persistency of antimicrobial activity of silver-loaded zeolites was investigated by retrieving each silver-loaded zeolite from the first exposure cultures, washed copiously with de-ionised water and adding to fresh bacterial suspensions. To understand the mode of antimicrobial activity of the silver-loaded zeolites, the uptake of silver ions by the strains, composition of fatty acid, as well as the DNA content of Escherichia coli K12W-T was studied. The results obtained showed silver ions appeared to elute from the zeolites frameworks into the TSB in anomalous trend. All three microorganisms were completely inhibited within one hour with the silver-loaded zeolites retaining their antimicrobial activity. The release of silver ions from the zeolites frameworks followed first-order kinetics with varying rate constants and half-lives. The fatty acid composition of all strains as well as the DNA content of Escherichia coli K12W-T were affected by the action of silver ions.

APA, Harvard, Vancouver, ISO, and other styles

39

Gordon, Jacques Nicholas. "Hidden housing production--residential conversion activity in the City of Boston." Thesis, Massachusetts Institute of Technology, 1987. http://hdl.handle.net/1721.1/74333.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Urban Studies, 1987.
M.I.T. copy lacks leaf 223. Title as it appeared in M.I.T. Graduate List June 1987: Hidden housing production : conversion activity in the city of Boston.
Bibliography: v. 2, leaves 257-263.
by Jacques Nicholas Gordon.
Ph.D.

APA, Harvard, Vancouver, ISO, and other styles

40

Abadi, Giso. "The economical production of bryostatin & Et-743 with biological activity." Thesis, University of Sunderland, 2009. http://sure.sunderland.ac.uk/3697/.

Full text

Abstract:

Within the past fifty years, drugs from the sea have become an increasing industry for the identification and isolation of new medicinal agents. Bryozoa, sea squirts and corals are examples of many organisms that have been collected and tested for medicinal activity. Clinical testing’s of drugs such as bryostatin 1 and Et-743 have shown much success against various cancers such as kidney, prostate, and leukemia, etc. However, there are many problems affecting the economical availability of such drugs such as: 1. the potential endangerment of marine organisms due to massive quantities required for clinical use; 2. seasonal availability of the organisms and 3. numerous synthetic steps resulting in low percent yields to name a few. Detailed analyses conducted of the environment of these marine organisms resulted in the composition of chemicals that were used as an artificial property to mimic the host organisms and their environments, resulting in the cultivation of the bacteria suggestively responsible for the production of these active compounds. Other experiments conducted, involved the esterification of bryostatin 1 under various conditions, in order to show that such compounds produced, are more environmentally obtainable as opposed to being specie dependent. Computational studies binding Fe3+ to different marine natural products was also conducted in order to determine any siderophore properties that each may have. From this study cell line tests were conducted in order to determine the efficacy of a bryostatin-Fe3+ complex in comparison to bryostatin 1. Preliminary results from all the artificial media used to isolate and produce the bryostatins and Et-743 showed prominence; however, results were inconclusive due low detection values and marginal errors.

APA, Harvard, Vancouver, ISO, and other styles

41

Swan, Lorraine. "Minerals and Managers: : production contexts as evidence for social organization in Zimbabwean prehistory." Doctoral thesis, Uppsala University, African and Comparative Archaeology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8588.

Full text

Abstract:

In the Zimbabwean past, farming societies utilized mineral resources for their own use and for exchange to local and regional populations, as well as to markets beyond African borders. Successful agriculture was constrained by environmental hazards, principally unpredictable and often inadequate rainfall. Farming communities managed this predicament in various ways. It is likely that some groups used mineral resources found in the vicinity of their settlements to produce materials or items to exchange. The social contexts that defined the nature of mineral production and exchange altered between the mid-first and mid-second millennium AD, as social ranks emerged and political and economic systems became increasingly complex. The thesis is a commentary on how the motivation of society to broaden its resource base, to improve the benefits to households and to society in general, contributed to the emergence of leaders and, ultimately, of an elite class. The focus of the research is on iron and copper production because the author has examined gold production thoroughly in a previous study. Four published papers outline the history of iron and copper production in Zimbabwe. The papers provide case studies of the scale and social context of iron and copper production and exchange.

APA, Harvard, Vancouver, ISO, and other styles

42

Lantz, Jenny. "Taste at work : on taste and organization in the field of cultural production." Doctoral thesis, Handelshögskolan i Stockholm, Institutionen för Företagande och Ledning, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:hhs:diva-1549.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Swan, Lorraine M. "Minerals and managers : production contexts as evidence for social organization in Zimbabwean prehistory /." Uppsala : Department of Archaeology and Ancient History, African and Comparative Archaeology, Uppsala University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8588.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Godinho, Irina Sofia Marques. "Production of fish protein hydrolysates by a marine proteolytic strain." Master's thesis, ISA, 2013. http://hdl.handle.net/10400.5/6475.

Full text

Abstract:

Mestrado em Engenharia Alimentar - Instituto Superior de Agronomia
The preparation of fish protein hydrolysates by a fermentative process is an alternative to classical preparation using added proteolytic enzymes, taking advantage of the wide spectrum of proteolytic enzymes produced by microorganisms and increasing the complexity of the peptide mixture obtained. Thus, the objective of this work was to prepare fermentative protein hydrolysates (FPH) from a commercial cod protein hydrolysate (CPH) using an indigenous marine proteolytic strain. The bacterial growth was performed in liquid culture media, containing three concentrations of CPH (1, 2 and 4%), yeast extract (0.5%) and sucrose (0.5%), with continuous shaking, at 30 ºC for 24, 50 and 72 hours. The parameters evaluated were the culture growth, enzymatic activity, protein content and recovery, peptide profile, degree of hydrolysis and antioxidant activity, measured by DPPH and ABTS radical scavenging activity, reducing power and metal chelating activity. Bacterial growth and enzymatic activity reached their maximums after 24 hours of fermentation, and all FPH showed the disappearance of peptides in the range of 200 – 400 Da. In the set of samples, 4 % FPH recorded the highest values of protein content and recovery, but 1 % and 2 % FPH were the samples that presented improved antioxidant activity.

APA, Harvard, Vancouver, ISO, and other styles

45

Говорун, С. А. "Удосконалення організації маркетингової діяльності зовнішньоорієнтованого підприємства." Master's thesis, Українська академія банківської справи Національного банку України, 2010. http://essuir.sumdu.edu.ua/handle/123456789/49653.

Full text

Abstract:

Формування ринкової економіки зумовило необхідність переорієнтації виробництва та реалізації товарів на задоволення потреб і запитів споживачів. Нова система господарювання в Україні викликала великий інтерес з боку українських підприємців та економістів до маркетингової концепції управління на рівні підприємства, об’єднання. Закордонний досвід переконує в тому, що маркетингова концепція сприяє і вдосконаленню системи внутрішньофірмового управління, і успіху підприємства у конкурентній боротьбі.
Formation of a market economy has necessitated reorientation of production and sale of goods to meet the needs and demands of consumers. The new system of management in Ukraine attracted great interest from Ukrainian businessmen and economists to the marketing concept of enterprise-level organizations. Overseas experience shows that the marketing concept facilitates intracompany and improve management, and enterprise success in the competition.

APA, Harvard, Vancouver, ISO, and other styles

46

Sommer, Marius. "Effect of timing training in golf and soccer players : skill, movement organization, and brain activity." Doctoral thesis, Umeå universitet, Institutionen för psykologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-86664.

Full text

Abstract:

Background Although trainers and athletes consider ‘good timing skills’ to be critical for optimal sport performance, little is known in regard to how sport-specific skills may benefit from timing training. Thus, assuming that all motor performances are mediated by an internal timing mechanism, enhanced motor timing is expected to have positive effects on both planning and execution of movement performance, and consequently on complex sports actions as golf or soccer. Accordingly, in order to increase our knowledge of the importance of motor timing and possible effects of timing training, this thesis examines the effects of synchronized metronome training (SMT), thought to improve the execution of motor programs and to enhance motor skills in golf and soccer players. Methods Study I examined the effects of SMT on motor timing abilities and its potential effect on golf shot accuracy and consistency in 25 experienced male golfers. Additionally, Study II examined the effects of SMT on the spatiotemporal movement organisation and dynamics of the golf swing performance, as captured by kinematic measurements and analyses in thirteen male golfers. Study III examined the effect of SMT on accuracy and variability in a soccer specific, cross-pass task in elite and sub-elite female soccer players. Moreover, the underlying brain activity was assessed by means of functional magnetic resonance imaging (fMRI) to investigate the corresponding neural activity when passively observing the cross-pass task, and the possible pre- to post training effects. Results SMT was shown to improve motor timing ability, by means of less timing asynchrony and with associated changes in timing variability, in both golf- and soccer-players. Additionally, significant improvements in golf shot and soccer cross-pass performance, by means of significant increase in outcome accuracy combined with a decrease in outcome variability was found. From the kinematic investigation in Study II, results indicate that improved motor timing, as an effect of SMT, lead to a more coordinated and dynamic swing performance, and with decreased variability in the temporal structure of the swing motion. Finally, it was found that SMT induces changes in the activity of the action observation network (AON), underpinning action observation and action prediction, by means of decreased activation within bilateral cerebellum, fusiform gyrus and superior temporal gyrus. These findings hint at a more efficient pattern of neural recruitment during action observation, after SMT. Conclusion In summary, this thesis provides evidence that four weeks of SMT improved the participant’s motor timing and synchronization abilities, and showed influence on both behavioral and neurophysiological motor programs and skill performance in golf and soccer players. Thus, by improved outcome accuracy and decreased variability, affecting the coordinated movement pattern and organisation, as well as affecting the associated underlying brain activation.

APA, Harvard, Vancouver, ISO, and other styles

47

Wilson, William Curtis. "You are what you do : the self-organization of daily activity in the urban environment." Thesis, University of Cambridge, 1985. https://www.repository.cam.ac.uk/handle/1810/273095.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Ismail, Safwan. "Production of fatty acid alcohol esters by esterase activity from Pseudomonas fragi." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21574.

Full text

Abstract:

Pseudomonas fragi CRDA 037 was used as source of intracellular esterase, which remained attached to the cell membrane, and characterized. Several mechanical methods of disruption were used including glass beads (MSK), sonication, French press and combinations of these methods. The cellular debris were also treated with detergents such as CHAPS and Triton X-100 in the presence of chelating agent ethylenediaminetetra acetic acid (EDTA). The esterase activity remained in the cellular debris which was therefore use as a source of enzyme for kinetic studies. In the case of glass beads homogenization, the activity was found to decrease as a function of time of disruption. The results of chemical treatment showed that the esterase was characterized in terms of detergent and EDA action as well as substrate specificity. Triton X-100 and EDTA had no effect on the esterase activity and did not denature the enzyme. The substrate specificity with cells and cellular debris were carried out. The valeric acid was the best in term of esterase activity among fatty acids used in the study. (Abstract shortened by UMI.)

APA, Harvard, Vancouver, ISO, and other styles

49

Ismail, Safwan. "Production of fatty acid alcohol esters by esterase activity from Pseudomonas fragi." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ50798.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Link, J. M., M. J. O'Hara, S. C. Shoner, J. O. Armstrong, and K. A. Krohn. "A practical high current 11 MeV production of high specific activity 89Zr." Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-166445.

Full text

Abstract:

Introduction Zr-89 is a useful radionuclide for radiolabeling proteins and other molecules.1,2 There are many reports of cyclotron production of 89Zr by the 89Y (p,n) reaction. Most irradiations use thin metal backed deposits of Y and irradiation currents up to 100 µA or thicker amounts of Y or Y2O3 with ~ 20 µA irradiations.3,4 We are working to develop high specific activity 89Zr using a low energy 11 MeV cyclotron. We have found that target Y metal contains carrier Zr and higher specific activities are achieved with less Y. The goal of this work was to optimize yield while minimizing the amount of Y that was irradiated. Material and Methods All irradiations were done using a Siemens Eclipse 11 MeV proton cyclotron. Y foils were used for the experiments described here. Y2O3 was tried and abandoned due to lower yield and poor heat transfer. Yttrium metal foils from Alfa Aesar, ESPI Metals and Sigma Aldrich, 0.1 to 1 mm in thickness, were tested. Each foil was irradiated for 10 to 15 minutes. The targets to hold the Y foils were made of aluminum and were designed to fit within the “paper burn” unit of the Siemen’s Eclipse target station, allowing the Y target body to be easily inserted and removed from the system. Several Al targets of 2 cm diam. and 7.6 cm long were tested with the face of the targets from 11, 26 or 90o relative to the beam to vary watts cm−2 on the foil. The front of the foils was cooled by He convection and the foil backs by conduction to the Al target body. The target body was cooled by conduction to the water cooled Al sleeve of the target holder. Results and Conclusion The best target was two stacked, 0.25 mm thick, foils to stop beam. 92% of the 89Zr activity was in the front 0.25 mm Y foil. With the greatest slant we could irradiate up to 30 µA of beam on tar-get. However, the 13×30 mm dimensions of the foil was more mass (0.41 g) and lower specific activity than was desired. Redesign of the target gave a target 90o to the beam with 12×12 mm foils (0.15 g/foil) that were undamaged with up to 30 µA irradiation when two foils were used. This design has a reduction in beam at the edges of ~10%. With this design, a single Y foil, 0.25 mm thick sustained over 31 µA of beam and a peak power on target of 270 watts cm−2. The product was radionuclidically pure 89Zr after all 89mZr and small amounts of 13N produced from oxygen at the surface had decayed (TABLE 1). Our conclusion is that the optimum target is a single 0.25 mm thick Y foil to obtain the greatest specific activity at this proton energy. This produces 167 MBq of 89Zr at EOB with a 15 minute and 31 µA irradiation. We are continuing to redesign the clamp design to reduce losses at the edge of the beam.

APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic 'Organization of production activity'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles