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Journal articles on the topic 'ORGANO ARSENICALS'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Hanaoka, Ken’ichi, Walter Goessler, Toshikazu Kaise, et al. "Occurrence of a few organo-arsenicals in jellyfish." Applied Organometallic Chemistry 13, no. 2 (1999): 95–99. http://dx.doi.org/10.1002/(sici)1099-0739(199902)13:2<95::aid-aoc804>3.0.co;2-t.

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2

Hanaoka, Ken'ichi, Hirokazu Ohno, Namiko Wada, et al. "Occurrence of organo-arsenicals in jellyfishes and their mucus." Chemosphere 44, no. 4 (2001): 743–49. http://dx.doi.org/10.1016/s0045-6535(00)00291-5.

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3

Shi, Xue-Min, Wen-Yan She, Ting-Ting Liu, Lian-Xun Gao, Yu-Jiao Liu, and Yi Liu. "1,3-Benzodioxole Derivatives Improve the Anti-Tumor Efficiency of Arsenicals." International Journal of Molecular Sciences 23, no. 13 (2022): 6930. http://dx.doi.org/10.3390/ijms23136930.

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Arsenicals have been widely used in the treatment of cancers such as leukemia and other tumors. However, their side effects limit their clinical application. Stiripentol, a second-line adjunctive treatment for epilepsy with a good safety profile, inhibits microsomal cytochrome-P450-family enzymes to extend the retention time of co-administration. Inspired by the metabolism of stiripentol, the 1,3-benzodioxole responsible for the inhibition and its metabolic derivatives were conjugated with arsenical precursors. The fabricated arsenicals were eliminated much slower in mice and maintained an eff

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4

Majumdar, Kunal Kanti. "Chronic arsenic poisoning and Hepatotoxicity." Journal of Comprehensive Health 5, no. 1 (2020): 24–33. http://dx.doi.org/10.53553/jch.v05i01.003.

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Arsenic (As) is a toxic and carcinogenic metalloid. Arsenic toxicity is a global health problem affecting many millions of people. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Chronic arsenic poisoning, or arsenicosis, is typically defined by the classical skin manifestations, together with involvement of internal organs, such as liver injury, in the presence of known arsenic exposure. Probably, the most important concern with arsenic exposure is its carcino

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5

Adeyi, Olubisi E., Oluwatobi T. Somade, Emmanuel I. Ugwor, Olayinka A. Oladimeji, Happiness O. Ozoemena, and Akindele O. Adeyi. "Assessments of the Safety of Arsenicals on Dyslipidaemia and Reproductive Organ Morphology of Albino Rats." Nigerian Journal of Biochemistry and Molecular Biology 39, no. 2 (2024): 49–56. http://dx.doi.org/10.4314/njbmb.v39i2.3.

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Epidemiological studies have implicated Arsenic (As) an environmental toxicant in the etiology of many diseases which have been associated with dyslipidaemia and cardiovascular abnormalities. This study investigated the comparative effect of sub-chronic exposure to two arsenicals on the lipid profiles and morphology of the reproductive organs. Fifty albino rats were divided into five groups of 10 animals each (5 male and 5 female) were exposed to different doses of arsenic (As) either as sodium arsenite or sodium arsenate for 5 weeks. Lipids [triacylglycerol (TAG), cholesterol (CHOL) and phosp

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6

Liu, Dan, Xiaoxu Duan, Dandan Dong, et al. "Activation of the Nrf2 Pathway by Inorganic Arsenic in Human Hepatocytes and the Role of Transcriptional Repressor Bach1." Oxidative Medicine and Cellular Longevity 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/984546.

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Previous studies have proved that the environmental toxicant, inorganic arsenic, activates nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in many different cell types. This study tried to explore the hepatic Nrf2 pathway upon arsenic treatment comprehensively, since liver is one of the major target organs of arsenical toxicity. Our results showed that inorganic arsenic significantly induced Nrf2 protein and mRNA expression in Chang human hepatocytes. We also observed a dose-dependent increase of antioxidant response element- (ARE-) luciferase activity. Both the mRNA and protein lev

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7

Poon, Louis, Shaguftah Younus, and Lee D. Wilson. "Adsorption study of an organo-arsenical with chitosan-based sorbents." Journal of Colloid and Interface Science 420 (April 2014): 136–44. http://dx.doi.org/10.1016/j.jcis.2014.01.003.

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8

Sarkar, Dibyendu, Rupali Datta, and Saurabh Sharma. "Fate and bioavailability of arsenic in organo-arsenical pesticide-applied soils." Chemosphere 60, no. 2 (2005): 188–95. http://dx.doi.org/10.1016/j.chemosphere.2004.11.060.

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9

Tanaka, Joji, Seiji Tani, Raoul Peltier, et al. "Synthesis, aggregation and responsivity of block copolymers containing organic arsenicals." Polymer Chemistry 9, no. 13 (2018): 1551–56. http://dx.doi.org/10.1039/c7py01852e.

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10

Tanaka, Joji, Alexander Evans, Pratik Gurnani, Andrew Kerr, and Paul Wilson. "Functionalisation and stabilisation of polymeric arsenical nanoparticles prepared by sequential reductive and radical cross-linking." Polymer Chemistry 11, no. 14 (2020): 2519–31. http://dx.doi.org/10.1039/d0py00229a.

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11

Chowdhury, A. Z. M. Shaifullah, Yasuyuki Shibata, Masatoshi Morita, and Kunimitsu Kaya. "Synthesis of Arsenical Adduct: Synthesis and Transformation of Dimercapto Compound to Arsenical Adduct." Phosphorus, Sulfur, and Silicon and the Related Elements 177, no. 2 (2002): 497–509. http://dx.doi.org/10.1080/10426500210241.

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12

Liu, Yu-Jiao, Xiao-Yang Fan, An-Dong Wang, et al. "LDHA Suppression Altering Metabolism Inhibits Tumor Progress by an Organic Arsenical." International Journal of Molecular Sciences 20, no. 24 (2019): 6239. http://dx.doi.org/10.3390/ijms20246239.

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Based on the potential therapeutic value in targeting metabolism for the treatment of cancer, an organic arsenical PDT-BIPA was fabricated, which exerted selective anti-cancer activity in vitro and in vivo via targeting lactate dehydrogenase A (LDHA) to remodel the metabolic pathway. In details, the precursor PDT-BIPA directly inhibited the function of LDHA and converted the glycolysis to oxidative phosphorylation causing ROS burst and mitochondrial dysfunction. PDT-BIPA also altered several gene expression, such as HIF-1α and C-myc, to support the metabolic remodeling. All these changes lead

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13

Tanaka, Joji, Thomas P. Davis, and Paul Wilson. "Organic Arsenicals as Functional Motifs in Polymer and Biomaterials Science." Macromolecular Rapid Communications 39, no. 19 (2018): 1800205. http://dx.doi.org/10.1002/marc.201800205.

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14

Datta, Rupali, Dibyendu Sarkar, Saurabh Sharma, and Kumarswamy Sand. "Arsenic biogeochemistry and human health risk assessment in organo-arsenical pesticide-applied acidic and alkaline soils: An incubation study." Science of The Total Environment 372, no. 1 (2006): 39–48. http://dx.doi.org/10.1016/j.scitotenv.2006.08.003.

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15

Quazi, Shahida, Dibyendu Sarkar, and Rupali Datta. "Changes in arsenic fractionation, bioaccessibility and speciation in organo-arsenical pesticide amended soils as a function of soil aging." Chemosphere 84, no. 11 (2011): 1563–71. http://dx.doi.org/10.1016/j.chemosphere.2011.05.047.

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16

Liu, Ting, Bin Wang, Ru He, et al. "A novel hydrogen-bonded organic framework for the sensing of two representative organic arsenics." Canadian Journal of Chemistry 98, no. 7 (2020): 352–57. http://dx.doi.org/10.1139/cjc-2019-0417.

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A novel fluorescent hydrogen-bonded organic framework with a double fold interpenetrated structure, HOF-22, has been successfully constructed and structurally characterized. HOF-22 is capable of sensitive detection of two representative organic arsenics from aqueous solution.

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17

Wang, Zhongwen, Hongquan Zhang, Xing-Fang Li, and X. Chris Le. "Study of interactions between arsenicals and thioredoxins (human andE. coli) using mass spectrometry." Rapid Communications in Mass Spectrometry 21, no. 22 (2007): 3658–66. http://dx.doi.org/10.1002/rcm.3263.

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18

Huang, Hsin-Wei, Chih-Hung Lee, and Hsin-Su Yu. "Arsenic-Induced Carcinogenesis and Immune Dysregulation." International Journal of Environmental Research and Public Health 16, no. 15 (2019): 2746. http://dx.doi.org/10.3390/ijerph16152746.

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Arsenic, a metal ubiquitously distributed in the environment, remains an important global health threat. Drinking arsenic-contaminated water is the major route of human exposure. Exposure to arsenic contributes to several malignancies, in the integumentary, respiratory, hepatobiliary, and urinary systems. Cutaneous lesions are important manifestations after long-term arsenic exposure. Arsenical skin cancers usually herald the development of other internal cancers, making the arsenic-induced skin carcinogenesis a good model to investigate the progression of chemical carcinogenesis. In fact, onl

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19

Yatchang, Marina Fosso, Bini Mathew, Ritesh K. Srivastava, et al. "Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals." Bioorganic & Medicinal Chemistry Letters 64 (May 2022): 128696. http://dx.doi.org/10.1016/j.bmcl.2022.128696.

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20

Tobin, Hayden, Evelina Liarou, Ji-Inn Song, Alexandros Magiakos, and Paul Wilson. "Synthesis and self-assembly of corona-functionalised polymeric arsenical nanoparticles." European Polymer Journal 144 (February 2021): 110235. http://dx.doi.org/10.1016/j.eurpolymj.2020.110235.

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21

Nurchi, Valeria M., Aleksandra Buha Djordjevic, Guido Crisponi, Jan Alexander, Geir Bjørklund, and Jan Aaseth. "Arsenic Toxicity: Molecular Targets and Therapeutic Agents." Biomolecules 10, no. 2 (2020): 235. http://dx.doi.org/10.3390/biom10020235.

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High arsenic (As) levels in food and drinking water, or under some occupational conditions, can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to unacceptable amounts of As through drinking water and food. Highly exposed individuals may develop acute, subacute, or chronic signs of poisoning, characterized by skin lesions, cardiovascular symptoms, and in some cases, multi-organ failure. Inorganic arsenite(III) and organic arsenicals with the general formula R-As2+ are bound tightly to thiol groups, particularly to vicinal dithiols such as dihydrolipoic aci

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22

Fan, Xiao-Yang, Yu-Jiao Liu, Kai Chen, et al. "Organic arsenicals target thioredoxin reductase followed by oxidative stress and mitochondrial dysfunction resulting in apoptosis." European Journal of Medicinal Chemistry 143 (January 2018): 1090–102. http://dx.doi.org/10.1016/j.ejmech.2017.05.022.

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23

Francesconi, Kevin A., and John S. Edmonds. "A novel arsenical in clam kidney identified by liquid chromatography/electrospray ionisation mass spectrometry." Rapid Communications in Mass Spectrometry 15, no. 17 (2001): 1641–46. http://dx.doi.org/10.1002/rcm.420.

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24

BURRI, CHRISTIAN. "Chemotherapy against human African trypanosomiasis: Is there a road to success?" Parasitology 137, no. 14 (2010): 1987–94. http://dx.doi.org/10.1017/s0031182010001137.

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SUMMARYFor over fifty years, human African trypanosomiasis (HAT, sleeping sickness) has been treated with suramin, pentamidine and the very toxic organo-arsenical melarsoprol that was the only drug available for effective treatment of the second stage of the disease. Recently there have been significant efforts using molecular and biochemical approaches to drug design, including high-throughput screening, but the number of lead compounds with promising activity againstT. bruceispp. and an acceptable toxicity index has remained astonishingly small. Clinical research continues to be difficult du

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25

Hansen, Frantz, and Knud O. Møller. "Arsenic Contents of Human Organs after Fatal Poisoning with Arsenic Trioxide and other Arsenical Compounds, with some Remarks on the Manifestations of Arsenic Poisoning." Acta Pharmacologica et Toxicologica 5, no. 2 (2009): 135–52. http://dx.doi.org/10.1111/j.1600-0773.1949.tb03380.x.

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26

Franco, A. Haiver E., Crispín Celis, Sandra Forero, Luis M. Pombo, and A. Oscar E. Rodríguez. "Phytoremediating Activity of Baccharis Latifolia in Soils Contaminated with Heavy Metals." International Journal of Current Pharmaceutical Review and Research 9, no. 4 (2018): 38–43. https://doi.org/10.5281/zenodo.12674178.

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Phytoremediation as an economic alternative with less impact on the environment uses species that accumulate heavymetals in their organs during their development; in this research, the ability of the species Baccharis latifolia (Ruiz & Pav.)Pers. - Chilca (Asteraceae) to absorb and accumulate heavy metals such as cadmium, chromium, lead, cobalt and arsenicwas evaluated to determine if it is a species potential for phytoremediation processes; the species was collected inVillapinzón (upper basin of the Bogotá River), a sector with a high degree of contamination by heavy metals

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27

Yuan, Bo, Hidetomo Kikuchi, Jingmei Li, et al. "Cytotoxic Effects of Darinaparsin, a Novel Organic Arsenical, against Human Leukemia Cells." International Journal of Molecular Sciences 24, no. 3 (2023): 2282. http://dx.doi.org/10.3390/ijms24032282.

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To explore the molecular mechanisms of action underlying the antileukemia activities of darinaparsin, an organic arsenical approved for the treatment of peripheral T–cell lymphoma in Japan, cytotoxicity of darinaparsin was evaluated in leukemia cell lines NB4, U-937, MOLT-4 and HL-60. Darinaparsin was a more potent cytotoxic than sodium arsenite, and induced apoptosis/necrosis in NB4 and HL-60 cells. In NB4 cells exhibiting the highest susceptibility to darinaparsin, apoptosis induction was accompanied by the activation of caspase-8/-9/-3, a substantial decrease in Bid expression, and was supp

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28

Tanaka, Joji, Guillaume Moriceau, Alexander Cook, et al. "Tuning the Structure, Stability, and Responsivity of Polymeric Arsenical Nanoparticles Using Polythiol Cross-Linkers." Macromolecules 52, no. 3 (2019): 992–1003. http://dx.doi.org/10.1021/acs.macromol.8b02459.

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29

Anushree, Md Zeeshan Ali, Anwar L. Bilgrami, and Jawaid Ahsan. "Acute Exposure to Arsenic Affects Pupal Development and Neurological Functions in Drosophila melanogaster." Toxics 11, no. 4 (2023): 327. http://dx.doi.org/10.3390/toxics11040327.

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Millions of people in developing countries are affected by arsenic (As) toxicity and its prevalence. Arsenic’s detrimental effects on humans have been amplified by an unacceptable level of exposure to food and drinking water, the ongoing rise in industrial usage, and several other occupational conditions. Due to increased cellular absorption and the ability to cross the blood–brain barrier (BBB), inorganic arsenic (iAs) is extremely hazardous to living organisms in its trivalent form. Arsenic toxicity damages an organism’s tissues and organs, resulting in skin cancer, circulatory system abnorm

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30

Bhunia, Anjan K., and Stephen C. Miller. "Labeling Tetracysteine-Tagged Proteins with a SplAsH of Color: A Modular Approach to Bis-Arsenical Fluorophores." ChemBioChem 8, no. 14 (2007): 1642–45. http://dx.doi.org/10.1002/cbic.200700192.

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31

Alotaibi, Adullah, Godwin U. Ebiloma, Roderick Williams, et al. "Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana." Molecules 26, no. 13 (2021): 3912. http://dx.doi.org/10.3390/molecules26133912.

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Ethanolic extracts of samples of temperate zone propolis, four from the UK and one from Poland, were tested against three Trypanosoma brucei strains and displayed EC50 values < 20 µg/mL. The extracts were fractionated, from which 12 compounds and one two-component mixture were isolated, and characterized by NMR and high-resolution mass spectrometry, as 3-acetoxypinobanksin, tectochrysin, kaempferol, pinocembrin, 4′-methoxykaempferol, galangin, chrysin, apigenin, pinostrobin, cinnamic acid, coumaric acid, cinnamyl ester/coumaric acid benzyl ester (mixture), 4′,7-dimethoxykaempferol, and nari

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32

Lee, Eun Jeong, Jee Young Sung, Kyung Hee Koo, et al. "Anti-Tumor Effects of Sodium Meta-Arsenite in Glioblastoma Cells with Higher Akt Activities." International Journal of Molecular Sciences 21, no. 23 (2020): 8982. http://dx.doi.org/10.3390/ijms21238982.

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Glioblastoma is a type of aggressive brain tumor that grows very fast and evades surrounding normal brain, lead to treatment failure. Glioblastomas are associated with Akt activation due to somatic alterations in PI3 kinase/Akt pathway and/or PTEN tumor suppressor. Sodium meta-arsenite, KML001 is an orally bioavailable, water-soluble, and trivalent arsenical and it shows antitumoral effects in several solid tumor cells via inhibiting oncogenic signaling, including Akt and MAPK. Here, we evaluated the effect of sodium meta-arsenite, KML001, on the growth of human glioblastoma cell lines with di

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33

Schlegel, Irina, Claire M. F. De Goüyon Matignon de Pontourade, Joel-Benjamin Lincke, Irene Keller, Martin S. Zinkernagel, and Denise C. Zysset-Burri. "The Human Ocular Surface Microbiome and Its Associations with the Tear Proteome in Dry Eye Disease." International Journal of Molecular Sciences 24, no. 18 (2023): 14091. http://dx.doi.org/10.3390/ijms241814091.

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Although dry eye disease (DED) is one of the most common ocular surface diseases worldwide, its pathogenesis is incompletely understood, and treatment options are limited. There is growing evidence that complex interactions between the ocular surface microbiome (OSM) and tear fluid constituents, potentially leading to inflammatory processes, are associated with ocular surface diseases such as DED. In this study, we aimed to find unique compositional and functional features of the OSM associated with human and microbial tear proteins in patients with DED. Applying whole-metagenome shotgun seque

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34

Qu, Gaoyang, Zi Liu, Jiaxin Zhang, et al. "PINK1/Parkin-Mediated Mitophagy Partially Protects against Inorganic Arsenic-Induced Hepatic Macrophage Polarization in Acute Arsenic-Exposed Mice." Molecules 27, no. 24 (2022): 8862. http://dx.doi.org/10.3390/molecules27248862.

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Inorganic arsenic is a well-known environmental toxicant and carcinogen, and there is overwhelming evidence for an association between this metalloid poisoning and hepatic diseases. However, the biological mechanism involved is not well characterized. In the present study, we probed how inorganic arsenic modulates the hepatic polarization of macrophages, as well as roles of PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy participates in regulating the metalloid-mediated macrophage polarization. Our results indicate that acute arsenic exposure induced macrophage polarization with up-reg

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35

Liu, Yu‐Jiao, Xiao‐Yang Fan, Dong‐Dong Zhang, et al. "Dual Inhibition of Pyruvate Dehydrogenase Complex and Respiratory Chain Complex Induces Apoptosis by a Mitochondria‐Targeted Fluorescent Organic Arsenical in vitro and in vivo." ChemMedChem 15, no. 6 (2020): 552–58. http://dx.doi.org/10.1002/cmdc.201900686.

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36

Yamanaka, Kenzo, Fumiyo Takabayashi, Mutsumi Mizoi, Yan An, Akira Hasegawa, and Shoji Okada. "Oral Exposure of Dimethylarsinic Acid, a Main Metabolite of Inorganic Arsenics, in Mice Leads to an Increase in 8-Oxo-2′-deoxyguanosine Level, Specifically in the Target Organs for Arsenic Carcinogenesis." Biochemical and Biophysical Research Communications 287, no. 1 (2001): 66–70. http://dx.doi.org/10.1006/bbrc.2001.5551.

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37

Ungogo, Marzuq A., Gustavo D. Campagnaro, Ali H. Alghamdi, Manal J. Natto, and Harry P. de Koning. "Differences in Transporters Rather than Drug Targets Are the Principal Determinants of the Different Innate Sensitivities of Trypanosoma congolense and Trypanozoon Subgenus Trypanosomes to Diamidines and Melaminophenyl Arsenicals." International Journal of Molecular Sciences 23, no. 5 (2022): 2844. http://dx.doi.org/10.3390/ijms23052844.

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The animal trypanosomiases are infections in a wide range of (domesticated) animals with any species of African trypanosome, such as Trypanosoma brucei, T. evansi, T. congolense, T. equiperdum and T. vivax. Symptoms differ between host and infective species and stage of infection and are treated with a small set of decades-old trypanocides. A complication is that not all trypanosome species are equally sensitive to all drugs and the reasons are at best partially understood. Here, we investigate whether drug transporters, mostly identified in T. b. brucei, determine the different drug sensitivi

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38

Chowdhury, Uttam. "Arsenic Biotransformation: It is a complex process." International Journal of Biochemistry and Peptides 1, no. 1 (2021): 38–40. http://dx.doi.org/10.55124/ijbp.v1i1.142.

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Introduction  The IARC (1987)1 has classified arsenic as a group 1 human carcinogen. Chronic exposure to inorganic arsenic can cause cancerous1-4 and non-cancerous health hazards5,6 in humans. Arsenic can get entry into the human body via drinking water, eating food, inhaling dust, and/or ingesting soil. An important limitation on the scientific understanding of arsenic toxicity is the complexity of arsenic metabolism. Differences in susceptibility to arsenic toxicity might be manifested by differences in arsenic metabolism or in the prevalence of arsenic-associated diseases

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39

Chowdhury, Uttam. "Arsenic and Protein Expression: It might help to know the mechanism of As toxicity." International Journal of Biochemistry and Peptides 1, no. 1 (2021): 34–37. http://dx.doi.org/10.55124/ijbp.v1i1.124.

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Arsenic and Protein Expression: It might help to know the mechanism of As toxicity is described Introduction  One of the largest public health problems at present is the drinking of water containing levels of Inorg-As that are known to be carcinogenic. The chronic ingestion of Inorg-As can results in skin cancer, urinary bladder cancer, lungs cancer, kidneys cancer, liver cancer, and cancer of other human organs 1-6. The molecular mechanisms of the carcinogenicity and toxicity of inorganic arsenic are not well understood 7–9. Many mechanisms of arsenic toxicity and carc

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40

García-Sevillano, Miguel, Macarena González-Fernández, Rocío Jara-Biedma, et al. "Speciation of arsenic metabolites in the free-living mouse Mus spretus from Doñana National Park used as a bio-indicator for environmental pollution monitoring." Chemical Papers 66, no. 10 (2012). http://dx.doi.org/10.2478/s11696-012-0207-6.

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AbstractA speciation approach based on orthogonal chromatographic systems coupled to inductively coupled plasma mass spectrometry (ICP-MS) was used to characterise the biological response of free-living mice Mus spretus to environmental pollution caused by arsenic in different areas of the Doñana National Park (south-west Spain). The relative presence of inorganic and organic forms of arsenic was studied in cytosolic extracts from high metabolic activity organs of Mus spretus mice: kidneys, liver, and brain. An instrumental coupling of size-exclusion chromatography with UV and collision/reacti

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41

Alkhaldi, Abdulsalam A. M., Harry P. de Koning, and Syed Nasir Abbas Bukhari. "Antileishmanial and Antitrypanosomal Trends of Synthetic Tetralone Derivatives." Drug Development Research 86, no. 1 (2025). https://doi.org/10.1002/ddr.70055.

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ABSTRACTLeishmaniasis and trypanosomiasis are parasitic diseases that are closely linked to poverty, pose significant local burdens, and are common in tropical and subtropical regions. Various synthetic tetralone derivatives were studied as potential scaffolds for antileishmanial and antitrypanosomal activities. The compounds were studied for their effectiveness against multiple kinetoplastid protozoan pathogens: Leishmania major, Leishmania mexicana, and bloodstream trypomastigotes of Trypanosoma brucei brucei. Two different strains of T. b. brucei were used. The first strain was the wild‐typ

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42

Jakovljević, Ksenija, Tomica Mišljenović, Katerina Bačeva Andonovska та ін. "Thallium hyperaccumulation status of the violets of the Allchar arsenic-thallium deposit (North Macedonia) confirmed through synchrotron μXRF imaging". Metallomics, 17 жовтня 2023. http://dx.doi.org/10.1093/mtomcs/mfad063.

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Abstract The abandoned Allchar Mine in the Republic of North Macedonia is a globally unique deposit with the highest known grades of thallium (Tl) and arsenic (As) mineralisation. We aimed to determine the distribution of As and Tl in whole dehydrated shoots of the three Viola taxa using synchrotron μXRF analysis. Additionally, soil and plant organ samples were collected from all three Viola taxa at the Allchar site and analysed using ICP-AES. Concentrations of Tl were extremely high in all three Viola taxa (up to 58,900 mg kg−1), but concentrations of As were highly variable with V. tricolor

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43

Abhishek jain, Roshni jain, Swati jain, Subodh kumar jain, and Swati singh thakur. "Gut Microbiome and Health Assessment Due To Arsenic Toxicity: A Review." International Journal of Life Science and Pharma Research, July 9, 2022, 52–60. http://dx.doi.org/10.22376/ijpbs/lpr.2021.11.6.l52-60.

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Arsenic is considered as a class 1 carcinogen and first among toxicants ranked by the Environmental Protection Agency. Arsenic toxicity includes deleterious effect on gut microbiota, gastrointestinal disorder, immunological disturbances, disrupting metabolism and compromising the host health. Over 103–104 microorganisms with possibly 500 to 1,000 different species inhabit within the gut with 150 times more genes than the human genome. They help to digest food and play an essential role in our well- being. Gut microbiota affects our whole metabolism as well as the immune system of the host. Ars

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44

Gomila, Rosa M., and Antonio Frontera. "On the Existence of Pnicotgen Bonding Interactions in As(III) S‐Adenosylmethionine Methyltransferase Enzymes." Chemistry – An Asian Journal, February 26, 2024. http://dx.doi.org/10.1002/asia.202400081.

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As(III) S‐adenosylmethionine methyltransferases, pivotal enzymes in arsenic metabolism, facilitate the methylation of arsenic up to three times. This process predominantly yields trivalent mono‐ and dimethylarsenite, with trimethylarsine forming in smaller amounts. The strong affinity of As(III) for cysteine residues, forming As(III)‐thiolate bonds, is exploited in medical treatments. In this study, we extend the understanding of As(III)'s binding mechanisms, showing that, in addition to As(III)–S covalent bonds, noncovalent O···As pnictogen bonding plays a vital role. This interaction signifi

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Kitchin, Kirk T. "Recent Advances in Arsenic Carcinogenesis: Modes of Action, Animal Model Systems and Methylated Arsenic Metabolites." May 1, 2001. https://doi.org/10.1006/taap.2001.9157.

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Abstract:

Recent advances in our knowledge of arsenic carcinogenesis include the development of rat or mouse models for all human organs in which inorganic arsenic is known to cause cancer -skin, lung, urinary bladder, liver and kidney. Tumors can be produced from either promotion of carcinogenesis protocols (mouse skin and lungs, rat bladder, kidney, liver and thyroid) or from complete carcinogenesis protocols (rat bladder and mouse lung). Experiments with p53 +1- and K610DC transgenic mice administered dimethylarsinic acid (DMA) or arsenite have shown some degree of carcinogenic, cocarcinogenic or pro

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