Relevant bibliographies by topics / Organotypic

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  1. Dissertations / Theses

Academic literature on the topic 'Organotypic'

Author: Grafiati
Published: 1 April 2023

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Dissertations / Theses on the topic "Organotypic"

1

Li, Daqing. "Entorhino-hippocampal projections in organotypic cultures." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315340.

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2

Mbobo, Buchule. "Modelling neuroimmune interactions using organotypic slice cultures." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/24907.

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Tuberculosis predominantly manifests in the form of a pulmonary infection, but may spread out into other parts of the body and is then referred to as extrapulmonary tuberculosis (EPTB). One form of EPTB is an infection of the central nervous system (brain & spinal cord), CNS-TB. Although CNS-TB is relatively rare, accounting for about 5% of EPTB, it is characterised by high morbidity and mortality, particularly for children and immunosuppressed individuals. To examine the effects of a Mycobacterium tuberculosis infection of neural tissue, researchers have hitherto relied on two animal models n
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Steinmeyer, Joseph D. (Joseph Daly). "Rapid single-cell electroporation for labeling organotypic cultures." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/60188.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.<br>Vita.<br>Includes bibliographical references (p. 37-39).<br>Single-cell electroporation is a technique for transfecting individual cells in tissue culture at relatively high efficiencies, however it is both time-consuming and low-throughput and this limits the number of different labeling agents that can be effectively introduced into a region of tissue in reasonable periods of time. A novel system that will rapidly load, clean, and accurately position a glass micropipette elect
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Vu, Lucas Trung. "Proteomic Analysis of Three Dimensional Organotypic Liver Models." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/77033.

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In vitro liver models that closely mimic the in vivo microenvironment are central for understanding hepatic functions and intercellular communication processes. Bottom-up shotgun proteomic analysis of the hepatic cells can lend insight into such processes. This technique employs liquid chromatography-tandem mass spectrometry (LC-MS/MS) for relative quantification of protein abundances by measuring intensities of their corresponding peptides. Organotypic 3D liver models have been developed in our laboratory that consist of hepatocytes and liver sinusoidal endothelial cells (LSECs) separated by
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Kazmi, B. "Oral and dermal fibroblasts in 3D organotypic co-culture." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17485/.

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It is widely observed that dermal wound healing results in the re-establishment of skin continuity through the formation of a scar. In comparison oral wounds heal more rapidly, with less visible scarring. The diverse nature of sub-epithelial fibroblasts has targeted them as mediators for such a distinction in phenotype. Fibroblasts and their differentiated form, the myofibroblast (characterised by the expression of α-SMA), are chief synthesisers of the ECM during wound healing. Myofibroblasts in particular play an important role in wound contracture, ECM synthesis and remodelling during normal
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Frantseva, Marina. "H¦2O¦2 induced toxicity in rat organotypic hippocampal cultures." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0028/MQ51596.pdf.

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7

Phillips, Wiktor Samuel. "Studies of Respiratory Rhythm Generation Maintained in Organotypic Slice Cultures." W&M ScholarWorks, 2016. https://scholarworks.wm.edu/etd/1499449864.

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Breathing is an important rhythmic motor behavior whose underlying neural mechanisms can be studied in vitro. The study of breathing rhythms in vitro has depended upon reduced preparations of the brainstem that both retain respiratory-active neuronal populations and spontaneously generate respiratory-related motor output from cranial and spinal motor nerves. Brainstem-spinal cord en bloc preparations and transverse medullary slices of the brainstem have greatly improved the ability of researchers to experimentally access and thus characterize interneurons important in respiratory rhythmogenesi
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Jussila, T. (Tommi). "Modelling cancer: recapitulation of tumor growth in experimental systems in vivo and in vitro." Doctoral thesis, University of Oulu, 2000. http://urn.fi/urn:isbn:9514256433.

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Abstract The purpose of the study was to evaluate model systems of cancer development and compare some of their critical features with cancer development in vivo. Ovarian and endometrial cancers in man were used as correlates. Tumor development in experimental animals, exposed to carcinogens and UV irradiation, showed the entire spectrum of tumor development as compared to spontaneous carcinomas: hyperplasia, dysplasia, benign papillomas and malignant squamous cell carcinomas. For short-term analysis of differentiated homogenous cell populations, the transplant model proved most useful
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Acheva, Anna Rumenova. "Mechanisms of response to targeted irradiation in organotypic 3D skin cultures." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579565.

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Low linear energy transfer (LET) ionizing radiation as gamma and X-rays is widely used in the modem medicine for diagnostic and treatment purposes. Despite all the advantages that it gives for the early diagnosis and in the radiotherapy treatment of cancer, there are still unclear aspects about the mechanisms of the radiation effects in human tissue. Of particular interest is the detailed pathway which the directly irradiated cells use to communicate to their neighbours and its possible implications for radiotherapy applications. The aim of this project is to study the spatio-temporal signalli
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10

Froeling, Fieke E. M. "Tumour–stroma interactions in an organotypic culture model of pancreatic cancer." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/705.

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Pancreatic cancer is characterised by an intense fibrotic, or desmoplastic, stroma, which contributes to tumour progression. Three-dimensional in vitro culture models incorporating this non-tumour component may more closely recapitulate the complex in vivo situation. The aim of my project was to develop a physiologically relevant, three-dimensional organotypic culture model of pancreatic cancer to study the tumour-stroma interactions and its modulation by novel therapeutic agents. Cancer cells cultured on top of collagen/Matrigel gels, embedded with or without stromal cells (hTERT immortalised
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