Relevant bibliographies by topics / Organotypic brain slice

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Organotypic brain slice'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Organotypic brain slice"

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Humpel, Christian. "Organotypic Brain Slices of ADULT Transgenic Mice: A Tool to Study Alzheimer’s Disease." Current Alzheimer Research 16, no. 2 (2019): 172–81. http://dx.doi.org/10.2174/1567205016666181212153138.

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Transgenic mice have been extensively used to study the Alzheimer pathology. In order to reduce, refine and replace (3Rs) the number of animals, ex vivo cultures are used and optimized. Organotypic brain slices are the most potent ex vivo slice culture models, keeping the 3-dimensional structure of the brain and being closest to the in vivo situation. Organotypic brain slice cultures have been used for many decades but were mainly prepared from postnatal (day 8-10) old rats or mice. More recent work (including our lab) now aims to culture organotypic brain slices from adult mice including tran
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Humpel, Christian. "Organotypic Brain Slice Cultures." Current Protocols in Immunology 123, no. 1 (2018): e59. http://dx.doi.org/10.1002/cpim.59.

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Tsupykov, O., I. Lushnikova, Y. Nikandrova, et al. "A novel model of periventricular leukomalacia on mouse organotypic brain slice culture." Cell and Organ Transplantology 4, no. 2 (2016): 188–93. http://dx.doi.org/10.22494/cot.v4i2.60.

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The creation of adequate in vitro and in vivo models of neural tissue injury is essential to assess the therapeutic effect of pharmacological agents and regenerative potential of various types of stem cells in diseases of the central nervous system. The aim of this work was to create a novel model of cerebral white matter lesions – periventricular leukomalacia (PVL) – on murine organotypic brain slice culture.Materials and methods. The PVL model was developed on cultured organotypic mice brain slices subjected to oxygen-glucose deprivation (OGD) followed by addition of endotoxin lipopolysaccha
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Humpel, C. "Organotypic brain slice cultures: A review." Neuroscience 305 (October 2015): 86–98. http://dx.doi.org/10.1016/j.neuroscience.2015.07.086.

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Joost, Sarah, Stefan Mikkat, Michael Wille, Antje Schümann, and Oliver Schmitt. "Membrane Protein Identification in Rodent Brain Tissue Samples and Acute Brain Slices." Cells 8, no. 5 (2019): 423. http://dx.doi.org/10.3390/cells8050423.

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Acute brain slices are a sample format for electrophysiology, disease modeling, and organotypic cultures. Proteome analyses based on mass spectrometric measurements are seldom used on acute slices, although they offer high-content protein analyses and explorative approaches. In neuroscience, membrane proteins are of special interest for proteome-based analysis as they are necessary for metabolic, electrical, and signaling functions, including myelin maintenance and regeneration. A previously published protocol for the enrichment of plasma membrane proteins based on aqueous two-phase polymer sy
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Phillips, Wiktor S., Mikkel Herly, Christopher A. Del Negro, and Jens C. Rekling. "Organotypic slice cultures containing the preBötzinger complex generate respiratory-like rhythms." Journal of Neurophysiology 115, no. 2 (2016): 1063–70. http://dx.doi.org/10.1152/jn.00904.2015.

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Study of acute brain stem slice preparations in vitro has advanced our understanding of the cellular and synaptic mechanisms of respiratory rhythm generation, but their inherent limitations preclude long-term manipulation and recording experiments. In the current study, we have developed an organotypic slice culture preparation containing the preBötzinger complex (preBötC), the core inspiratory rhythm generator of the ventrolateral brain stem. We measured bilateral synchronous network oscillations, using calcium-sensitive fluorescent dyes, in both ventrolateral (presumably the preBötC) and dor
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Daza, R. A. M., C. Englund, and R. F. Hevner. "Organotypic Slice Culture of Embryonic Brain Tissue." Cold Spring Harbor Protocols 2007, no. 24 (2007): pdb.prot4914. http://dx.doi.org/10.1101/pdb.prot4914.

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Ucar, Buket, Sedef Yusufogullari, and Christian Humpel. "Collagen hydrogels loaded with fibroblast growth factor-2 as a bridge to repair brain vessels in organotypic brain slices." Experimental Brain Research 238, no. 11 (2020): 2521–29. http://dx.doi.org/10.1007/s00221-020-05907-7.

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Abstract Vessel damage is a general pathological process in many neurodegenerative disorders, as well as spinal cord injury, stroke, or trauma. Biomaterials can present novel tools to repair and regenerate damaged vessels. The aim of the present study is to test collagen hydrogels loaded with different angiogenic factors to study vessel repair in organotypic brain slice cultures. In the experimental set up I, we made a cut on the organotypic brain slice and tested re-growth of laminin + vessels. In the experimental set up II, we cultured two half brain slices with a gap with a collagen hydroge
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GIANINAZZI, C., M. SCHILD, N. MÜLLER, et al. "Organotypic slice cultures from rat brain tissue: a new approach forNaegleria fowleriCNS infectionin vitro." Parasitology 132, no. 6 (2005): 797–804. http://dx.doi.org/10.1017/s0031182005008619.

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The free-living amoebaNaegleria fowleriis the aetiological agent of primary amoebic meningoencephalitis (PAM), a disease leading to death in the vast majority of cases. In patients suffering from PAM, and in corresponding animal models, the brain undergoes a massive inflammatory response, followed by haemorrhage and severe tissue necrosis. Both,in vivoandin vitromodels are currently being used to study PAM infection. However, animal models may pose ethical issues, are dependent upon availability of specific infrastructural facilities, and are time-consuming and costly. Conversely, cell culture
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Croft, Cara L., and Wendy Noble. "Preparation of organotypic brain slice cultures for the study of Alzheimer’s disease." F1000Research 7 (May 15, 2018): 592. http://dx.doi.org/10.12688/f1000research.14500.1.

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Alzheimer's disease, the most common cause of dementia, is a progressive neurodegenerative disorder characterised by amyloid-beta deposits in extracellular plaques, intracellular neurofibrillary tangles of aggregated tau, synaptic dysfunction and neuronal death. There are no cures for AD and current medications only alleviate some disease symptoms. Transgenic rodent models to study Alzheimer’s mimic features of human disease such as age-dependent accumulation of abnormal beta-amyloid and tau, synaptic dysfunction, cognitive deficits and neurodegeneration. These models have proven vital for imp
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Dissertations / Theses on the topic "Organotypic brain slice"

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Croft, Cara Louise. "Investigating the mechanisms underlying Alzheimer's disease using a novel organotypic brain slice culture model." Thesis, King's College London (University of London), 2016. http://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-mechanisms-underlying-alzheimers-disease-using-a-novel-organotypic-brain-slice-culture-model(321a7046-c8e8-4c42-9abf-01792be7870c).html.

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Alzheimer's disease is a devastating progressive neurodegenerative disorder characterised by deposits of amyloid-β in extracellular plaques, intracellular neurofibrillary tangles comprising highly phosphorylated and aggregated tau species, synaptic dysfunction and neuronal death. Although several transgenic mouse models of Alzheimer's disease have been developed, in vivo studies using transgenic mice are time- and cost- consuming, and it is imperative that more ethically sustainable alternatives, which allow faster translation to the clinic, are developed. This thesis aims to determine if orga
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Ireland, Kirsty Anne. "Development of whole brain organotypic slice culture to investigate in vitro seeding of amyloid plaques." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28707.

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A feature of prion disease and other protein misfolding neurodegenerative disease is the formation of amyloid plaques. Amyloid is commonly found in the brain of individuals who have died from prion disease and Alzheimer’s disease. The formation and purpose of amyloid in such diseases is poorly understood and it is not currently known whether the material is neurotoxic, neuroprotective or an artefact. Several methods are used to investigate the formation of amyloid both in vitro and in vivo. A cell free protein conversion assay has been optimised to gain insight into the protein misfolding path
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Rambani, Komal. "Thick brain slice cultures and a custom-fabricated multiphoton imaging system: progress towards development of a 3D hybrot model." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/22702.

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Development of a three dimensional (3D) HYBROT model with targeted in vivo like intact cellular circuitry in thick brain slices for multi-site stimulation and recording will provide a useful in vitro model to study neuronal dynamics at network level. In order to make this in vitro model feasible, we need to develop several associated technologies. These technologies include development of a thick organotypic brain slice culturing method, a three dimensional (3D) micro-fluidic multielectrode Neural Interface system (µNIS) and the associated electronic interfaces for stimulation and recording
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Sygnecka, Katja. "Organotypic brain slice co-cultures of the dopaminergic system - A model for the identification of neuroregenerative substances and cell populations." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-188897.

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The development of new therapeutical approaches, devised to foster the regeneration of neuronal circuits after injury and/or in neurodegenerative diseases, is of great importance. The impairment of dopaminergic projections is especially severe, because these projections are involved in crucial brain functions such as motor control, reward and cognition. In the work presented here, organotypic brain slice co-cultures of (a) the mesostriatal and (b) the mesocortical dopaminergic projection systems consisting of tissue sections of the ventral tegmental area/substantia nigra (VTA/SN), in combinati
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Henning, Karen [Verfasser]. "Adeno-associated viral gene transfer to prevent the cellular phenotype of cortical organotypic brain-slice cultures derived from Gaucher’s disease type II mice. / Karen Henning." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1050978242/34.

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Sygnecka, Katja [Verfasser], Andrea [Akademischer Betreuer] Robitzki, Andrea [Gutachter] Robitzki, and Bernd [Gutachter] Heimrich. "Organotypic brain slice co-cultures of the dopaminergic system - A model for the identification of neuroregenerative substances and cell populations / Katja Sygnecka ; Gutachter: Andrea Robitzki, Bernd Heimrich ; Betreuer: Andrea Robitzki." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1239740050/34.

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Dorand, Rodney Dixon Jr. "DEFINING THE ROLE OF IMMUNE THERAPY IN PEDIATRIC CNS MALIGNANCY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1465566883.

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Llufriu-Dabén, Gemma. "Nouvelle approche neuroprotectrice et remyélinisante par l’étazolate dans le système nerveux central : implication des α-sécrétases (ADAM10)". Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB021/document.

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La démyélinisation et la mort oligodendrocytaire sont bien connues dans la sclérose en plaques (SEP). Au cours de ces dernières années, plusieurs études ont également décrit ce type de lésion après un traumatisme crânien (TC), participant à l’aggravation des lésions de la substance blanche, responsables des dysfonctionnements cognitifs et moteurs. Malgré de nombreux efforts, aucune thérapie efficace n’est disponible à ce jour pour traiter les lésions de la substance blanche. Dans ce contexte, une stratégie thérapeutique prometteuse serait de freiner la neuro-inflammation et la démyélinisation,
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Dias, Francisco Filipe Terra Silveira Schäller. "Organotypic brain slice cultures as a model to study supressors of amyloid-β toxicity relevant in Alzheimer’s disease". Master's thesis, 2020. http://hdl.handle.net/10451/48714.

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Tese de mestrado, Bioquímica (Bioquímica Médica) Universidade de Lisboa, Faculdade de Ciências, 2021<br>The accumulation of the amyloid-β peptide and its subsequent aggregation is followed by an initial neuroinflammatory response, thought as one of the driving processes leading to neurodegeneration in AD. Rising evidence describe this disease as an evolving two-stage inflammatory process, where early stages involve glial ability to regulate AD related mechanisms, maintaining an homeostatic environment prior to plaque formation, whilst late stages are characterized by an amyloid plaque-associat
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Urban, Nicolai Thomas. "Nanoscopy inside living brain slices." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-0023-9921-1.

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Book chapters on the topic "Organotypic brain slice"

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Pringle, A. K., J. Self, and Fausto Iannotti. "Reducing Conditions Produce a Loss of Neuroprotective Efficacy of Competitive but not non-Competitive Antagonists in a Model of NMDA-Mediated Excitotoxicity in Organotypic Hippocampal Slice Cultures." In Brain Edema XI. Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6346-7_16.

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O’Brien, John A., and Sarah C. R. Lummis. "Biolistic Transfection of Neurons in Organotypic Brain Slices." In Biolistic DNA Delivery. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-110-3_13.

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Humpel, C., and C. Weis. "Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices." In Ageing and Dementia Current and Future Concepts. Springer Vienna, 2002. http://dx.doi.org/10.1007/978-3-7091-6139-5_23.

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Schulz, Ellina, Tim Hohmann, Urszula Hohmann, et al. "Preparation and Culture of Organotypic Hippocampal Slices for the Analysis of Brain Metastasis and Primary Brain Tumor Growth." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1350-4_5.

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Kasri, Nael Nadif, Eve‐Ellen Govek, and Linda Van Aelst. "Characterization of Oligophrenin‐1, a RhoGAP Lost in Patients Affected with Mental Retardation: Lentiviral Injection in Organotypic Brain Slice Cultures." In Methods in Enzymology. Elsevier, 2008. http://dx.doi.org/10.1016/s0076-6879(07)00419-3.

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OHNISHI, T., and H. HARADA. "Analysis of Tumor Cell Invasion in Organotypic Brain Slices Using Confocal Laser-Scanning Microscopy." In Cell Biology. Elsevier, 2006. http://dx.doi.org/10.1016/b978-012164730-8/50046-0.

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Conference papers on the topic "Organotypic brain slice"

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Yu, Zhe, Woo Hyeun Kang, and Barclay Morrison. "Toward a Functional Tolerance Criterion for the Hippocampus Developed From Organotypic Slice Cultures." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19622.

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Approximately 1.5 million traumatic brain injuries (TBI) occur each year which result in 50,000 deaths, and about 80,000 people are left with a permanent disability. The annual cost associated with these injures is estimated to be $60 billion. Because there is no pharmacological treatment for TBI, engineering strategies to prevent these injuries enabled through an improved understanding of injury biomechanics is crucial. To this end, finite element models play a central role for predicting brain deformation induced by various loading scenarios such as falls or motor vehicle accidents. Novel pr
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Liu, Chao J., Ghaidan Shamsan, Taner Akkin, and David J. Odde. "Multimodality imaging of glioma cells migration in organotypic brain slice culture (Conference Presentation)." In Multimodal Biomedical Imaging XIII, edited by Fred S. Azar and Xavier Intes. SPIE, 2018. http://dx.doi.org/10.1117/12.2289334.

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Rossi, Marco, Antonio Tarantino, Renza Roncarati, et al. "Abstract 530: Evaluation ofin vitroinvasion of primary vs recurrent glioblastoma multiforme cells using organotypic rodent brain slice culture." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-530.

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Kolnik, Sarah E., Kate Hildahl, Kylie Corry, et al. "Erythropoietin Mitigates Inflammatory and Oxidative Stress Responses to Oxygen-Glucose Deprivation (OGD) in a Ferret Organotypic Brain Slice Model." In AAP National Conference & Exhibition Meeting Abstracts. American Academy of Pediatrics, 2021. http://dx.doi.org/10.1542/peds.147.3_meetingabstract.701.

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Shull, Gabriella, Christiane Haffner, Wieland Huttner, Elena Taverna, and Suhasa B. Kodandaramaiah. "Robotic Platform for the Delivery of Gene Products Into Single Cells in Organotypic Slices of the Developing Mouse Brain." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6899.

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Microinjection of genetic components and dye into organotypic slices provides excellent single cell resolution for unraveling biological complexities, but is extremely difficult and time consuming to perform manually resulting in low yield and low use in the developmental biology field. We developed a computer vision guided platform to inject specimen with mRNA, and/or dye and investigated the efficiency of the process using organotypic slices of the mouse developing neocortex. We demonstrate that the system significantly increases yield of injection relative to manual use by an order of magni
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