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Relevant bibliographies by topics / Organotypic Brain Slice Co-Cultures

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Academic literature on the topic 'Organotypic Brain Slice Co-Cultures'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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Journal articles on the topic "Organotypic Brain Slice Co-Cultures"

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Humpel, Christian. "Organotypic Brain Slice Cultures." Current Protocols in Immunology 123, no. 1 (2018): e59. http://dx.doi.org/10.1002/cpim.59.

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Humpel, Christian. "Organotypic Brain Slices of ADULT Transgenic Mice: A Tool to Study Alzheimer’s Disease." Current Alzheimer Research 16, no. 2 (2019): 172–81. http://dx.doi.org/10.2174/1567205016666181212153138.

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Transgenic mice have been extensively used to study the Alzheimer pathology. In order to reduce, refine and replace (3Rs) the number of animals, ex vivo cultures are used and optimized. Organotypic brain slices are the most potent ex vivo slice culture models, keeping the 3-dimensional structure of the brain and being closest to the in vivo situation. Organotypic brain slice cultures have been used for many decades but were mainly prepared from postnatal (day 8-10) old rats or mice. More recent work (including our lab) now aims to culture organotypic brain slices from adult mice including tran

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Humpel, C. "Organotypic brain slice cultures: A review." Neuroscience 305 (October 2015): 86–98. http://dx.doi.org/10.1016/j.neuroscience.2015.07.086.

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Phillips, Wiktor S., Mikkel Herly, Christopher A. Del Negro, and Jens C. Rekling. "Organotypic slice cultures containing the preBötzinger complex generate respiratory-like rhythms." Journal of Neurophysiology 115, no. 2 (2016): 1063–70. http://dx.doi.org/10.1152/jn.00904.2015.

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Study of acute brain stem slice preparations in vitro has advanced our understanding of the cellular and synaptic mechanisms of respiratory rhythm generation, but their inherent limitations preclude long-term manipulation and recording experiments. In the current study, we have developed an organotypic slice culture preparation containing the preBötzinger complex (preBötC), the core inspiratory rhythm generator of the ventrolateral brain stem. We measured bilateral synchronous network oscillations, using calcium-sensitive fluorescent dyes, in both ventrolateral (presumably the preBötC) and dor

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Heine, Claudia, Katja Sygnecka, Nico Scherf, Marcus Grohmann, Annett Bräsigk, and Heike Franke. "P2Y1 receptor mediated neuronal fibre outgrowth in organotypic brain slice co-cultures." Neuropharmacology 93 (June 2015): 252–66. http://dx.doi.org/10.1016/j.neuropharm.2015.02.001.

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Joost, Sarah, Stefan Mikkat, Michael Wille, Antje Schümann, and Oliver Schmitt. "Membrane Protein Identification in Rodent Brain Tissue Samples and Acute Brain Slices." Cells 8, no. 5 (2019): 423. http://dx.doi.org/10.3390/cells8050423.

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Acute brain slices are a sample format for electrophysiology, disease modeling, and organotypic cultures. Proteome analyses based on mass spectrometric measurements are seldom used on acute slices, although they offer high-content protein analyses and explorative approaches. In neuroscience, membrane proteins are of special interest for proteome-based analysis as they are necessary for metabolic, electrical, and signaling functions, including myelin maintenance and regeneration. A previously published protocol for the enrichment of plasma membrane proteins based on aqueous two-phase polymer sy

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Ucar, Buket, Sedef Yusufogullari, and Christian Humpel. "Collagen hydrogels loaded with fibroblast growth factor-2 as a bridge to repair brain vessels in organotypic brain slices." Experimental Brain Research 238, no. 11 (2020): 2521–29. http://dx.doi.org/10.1007/s00221-020-05907-7.

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Abstract Vessel damage is a general pathological process in many neurodegenerative disorders, as well as spinal cord injury, stroke, or trauma. Biomaterials can present novel tools to repair and regenerate damaged vessels. The aim of the present study is to test collagen hydrogels loaded with different angiogenic factors to study vessel repair in organotypic brain slice cultures. In the experimental set up I, we made a cut on the organotypic brain slice and tested re-growth of laminin + vessels. In the experimental set up II, we cultured two half brain slices with a gap with a collagen hydroge

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GIANINAZZI, C., M. SCHILD, N. MÜLLER, et al. "Organotypic slice cultures from rat brain tissue: a new approach forNaegleria fowleriCNS infectionin vitro." Parasitology 132, no. 6 (2005): 797–804. http://dx.doi.org/10.1017/s0031182005008619.

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The free-living amoebaNaegleria fowleriis the aetiological agent of primary amoebic meningoencephalitis (PAM), a disease leading to death in the vast majority of cases. In patients suffering from PAM, and in corresponding animal models, the brain undergoes a massive inflammatory response, followed by haemorrhage and severe tissue necrosis. Both,in vivoandin vitromodels are currently being used to study PAM infection. However, animal models may pose ethical issues, are dependent upon availability of specific infrastructural facilities, and are time-consuming and costly. Conversely, cell culture

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Spahr-Schopfer, Isabelle, Lazlo Vutskits, Nicholas Toni, Pierre-Alain Buchs, Lorena Parisi, and Dominique Muller. "Differential Neurotoxic Effects of Propofol on Dissociated Cortical Cells and Organotypic Hippocampal Cultures." Anesthesiology 92, no. 5 (2000): 1408–17. http://dx.doi.org/10.1097/00000542-200005000-00032.

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Background Propofol is a widely used anesthetic agent for adults and children. Although extensive clinical use has demonstrated its safety, neurologic dysfunctions have been described after the use of this agent. A recent study on a model of aggregating cell cultures reported that propofol might cause irreversible lesions of gamma-aminobutyric acid-mediated (GABAergic) neurons when administered at a critical phase of brain development. We investigated this issue by comparing the effects of long-term propofol treatment on two models of brain cultures: dissociated neonatal cortical cell cultures

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Croft, Cara L., and Wendy Noble. "Preparation of organotypic brain slice cultures for the study of Alzheimer’s disease." F1000Research 7 (May 15, 2018): 592. http://dx.doi.org/10.12688/f1000research.14500.1.

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Alzheimer's disease, the most common cause of dementia, is a progressive neurodegenerative disorder characterised by amyloid-beta deposits in extracellular plaques, intracellular neurofibrillary tangles of aggregated tau, synaptic dysfunction and neuronal death. There are no cures for AD and current medications only alleviate some disease symptoms. Transgenic rodent models to study Alzheimer’s mimic features of human disease such as age-dependent accumulation of abnormal beta-amyloid and tau, synaptic dysfunction, cognitive deficits and neurodegeneration. These models have proven vital for imp

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Dissertations / Theses on the topic "Organotypic Brain Slice Co-Cultures"

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Sygnecka, Katja. "Organotypic brain slice co-cultures of the dopaminergic system - A model for the identification of neuroregenerative substances and cell populations." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-188897.

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The development of new therapeutical approaches, devised to foster the regeneration of neuronal circuits after injury and/or in neurodegenerative diseases, is of great importance. The impairment of dopaminergic projections is especially severe, because these projections are involved in crucial brain functions such as motor control, reward and cognition. In the work presented here, organotypic brain slice co-cultures of (a) the mesostriatal and (b) the mesocortical dopaminergic projection systems consisting of tissue sections of the ventral tegmental area/substantia nigra (VTA/SN), in combinati

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Rambani, Komal. "Thick brain slice cultures and a custom-fabricated multiphoton imaging system: progress towards development of a 3D hybrot model." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/22702.

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Development of a three dimensional (3D) HYBROT model with targeted in vivo like intact cellular circuitry in thick brain slices for multi-site stimulation and recording will provide a useful in vitro model to study neuronal dynamics at network level. In order to make this in vitro model feasible, we need to develop several associated technologies. These technologies include development of a thick organotypic brain slice culturing method, a three dimensional (3D) micro-fluidic multielectrode Neural Interface system (ÂµNIS) and the associated electronic interfaces for stimulation and recording

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Sygnecka, Katja [Verfasser], Andrea [Akademischer Betreuer] Robitzki, Andrea [Gutachter] Robitzki, and Bernd [Gutachter] Heimrich. "Organotypic brain slice co-cultures of the dopaminergic system - A model for the identification of neuroregenerative substances and cell populations / Katja Sygnecka ; Gutachter: Andrea Robitzki, Bernd Heimrich ; Betreuer: Andrea Robitzki." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1239740050/34.

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Henning, Karen [Verfasser]. "Adeno-associated viral gene transfer to prevent the cellular phenotype of cortical organotypic brain-slice cultures derived from Gaucher’s disease type II mice. / Karen Henning." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1050978242/34.

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Dias, Francisco Filipe Terra Silveira Schäller. "Organotypic brain slice cultures as a model to study supressors of amyloid-β toxicity relevant in Alzheimer’s disease". Master's thesis, 2020. http://hdl.handle.net/10451/48714.

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Tese de mestrado, Bioquímica (Bioquímica Médica) Universidade de Lisboa, Faculdade de Ciências, 2021<br>The accumulation of the amyloid-β peptide and its subsequent aggregation is followed by an initial neuroinflammatory response, thought as one of the driving processes leading to neurodegeneration in AD. Rising evidence describe this disease as an evolving two-stage inflammatory process, where early stages involve glial ability to regulate AD related mechanisms, maintaining an homeostatic environment prior to plaque formation, whilst late stages are characterized by an amyloid plaque-associat

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Book chapters on the topic "Organotypic Brain Slice Co-Cultures"

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Pringle, A. K., J. Self, and Fausto Iannotti. "Reducing Conditions Produce a Loss of Neuroprotective Efficacy of Competitive but not non-Competitive Antagonists in a Model of NMDA-Mediated Excitotoxicity in Organotypic Hippocampal Slice Cultures." In Brain Edema XI. Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6346-7_16.

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Kasri, Nael Nadif, Eve‐Ellen Govek, and Linda Van Aelst. "Characterization of Oligophrenin‐1, a RhoGAP Lost in Patients Affected with Mental Retardation: Lentiviral Injection in Organotypic Brain Slice Cultures." In Methods in Enzymology. Elsevier, 2008. http://dx.doi.org/10.1016/s0076-6879(07)00419-3.

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Conference papers on the topic "Organotypic Brain Slice Co-Cultures"

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Yu, Zhe, Woo Hyeun Kang, and Barclay Morrison. "Toward a Functional Tolerance Criterion for the Hippocampus Developed From Organotypic Slice Cultures." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19622.

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Approximately 1.5 million traumatic brain injuries (TBI) occur each year which result in 50,000 deaths, and about 80,000 people are left with a permanent disability. The annual cost associated with these injures is estimated to be $60 billion. Because there is no pharmacological treatment for TBI, engineering strategies to prevent these injuries enabled through an improved understanding of injury biomechanics is crucial. To this end, finite element models play a central role for predicting brain deformation induced by various loading scenarios such as falls or motor vehicle accidents. Novel pr

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