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Relevant bibliographies by topics / Organotypic cell culture / Dissertations / Theses

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Dissertations / Theses on the topic 'Organotypic cell culture'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Barnhart, Kirstin Faye. "In vitro and in vivo analysis of differential gene expression between normal norfolk terrier dogs and those with an autosomal recessive mutation in KRT10." Texas A&M University, 2004. http://hdl.handle.net/1969.1/2671.

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Natural diseases caused by keratin mutations are rare and have only been reported in humans. We have recently identified a heritable skin disorder in Norfolk terriers caused by a mutation in KRT10. Affected dogs have a tendency to form shallow erosions or blisters following mild trauma, which is first noted after the birthing process. As the dogs age, they display generalized hyperpigmentation and scaling that is most severe in the axillary and inguinal regions. The main histologic and ultrastructural features include: marked hyperkeratosis, epidermal hyperplasia, prominent vacuolation of the

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2

Arunachalam, Sasi. "The Role of store operated calcium channels in human carcinoid cell lines." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1279216983.

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3

LACROIX, BORGEY BRIGITTE. "Cytodifferenciation de l'intestin humain." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13009.

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Definition du role des facteurs hormonaux, nutritionnels et des interactions epithelio-mesenchymateuses dans la maturation intestinale au cours du developpement et le long de l'axe crypto-villositaire

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4

Nurmenniemi, S. (Sini). "Analysis of cancer cell invasion with novel in vitro methods based on human tissues." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295799.

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Abstract Cancer progression is a multistep process dependent on tumour-stroma interactions. Various cell types, such as fibroblasts, endothelial, inflammatory and stem cells, as well as extracellular matrix (ECM) proteins, such as collagens, contribute to the tumour outcome. Tumour growth and invasion is accompanied by the proteolysis of ECM components mediated by various enzymes, such as matrix metalloproteases (MMPs). Proteolytic fragments released into the circulation may reflect cancer progression. The aim of this study was to develop novel in vitro methods for investigating cell invasion

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5

Steinmeyer, Joseph D. (Joseph Daly). "Rapid single-cell electroporation for labeling organotypic cultures." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/60188.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.<br>Vita.<br>Includes bibliographical references (p. 37-39).<br>Single-cell electroporation is a technique for transfecting individual cells in tissue culture at relatively high efficiencies, however it is both time-consuming and low-throughput and this limits the number of different labeling agents that can be effectively introduced into a region of tissue in reasonable periods of time. A novel system that will rapidly load, clean, and accurately position a glass micropipette elect

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6

N'tumba-Byn, Thierry. "Mécanismes d’action des perturbateurs endocriniens bisphénol A et phtalates sur le développement du testicule fœtal." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T006/document.

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Depuis plusieurs années, un nombre conséquent d’études décrivent une augmentation de l’incidence de pathologies liées à la fonction de reproduction masculine. Ces anomalies ont été regroupées sous le terme de « syndrome de dysgénésie testiculaire ». Ce syndrome aurait pour origine les effets délétères de polluants environnementaux sur le développement du testicule en période fœtale. Parmi ces polluants environnementaux, les phtalates et le bisphénol A (BPA) sont les plastifiants les plus produits et les plus répandus dans les objets de consommation courante. De nombreuses études leur sont cons

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7

Alahuhta, I. (Ilkka). "The microenvironment is essential for OTSCC progression." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526213583.

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Abstract The tumor microenvironment (TME) is critically important for tumor development. The microenvironment consists of fibroblasts, endothelial and immune cells as well as extracellular matrix (ECM), proteases and various other soluble factors produced by the cells. It is challenging to develop methods that appropriately mimic the human microenvironment, but this effort is essential in order to reliably elucidate the properties of potential anti-tumor drugs. The aim of this study was to create new 3D organotypic invasion models based on human tissue that would be used to study the effects o

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8

Sundquist, E. (Elias). "The role of tumor microenvironment on oral tongue cancer invasion and prognosis." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526217659.

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Abstract Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity. The 5-year mortality of OTSCC remains at about 50%. The tumor microenvironment (TME) is now recognized as an important factor in cancer progression and metastasis, as well as a tool for prognostication. The aim of this study was to elucidate the roles of TME hypoxia and soluble factors on cancer cell migration and invasion, and the prognostic value of two extracellular matrix (ECM) molecules: tenascin-C (TNC) and fibronectin (FN). Hypoxia was studied using oral squamous cell carcinoma cells in mi

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9

Kalaani, Joanna. "Molecular guidance of dopaminergic cells transplanted in a mouse model of Parkinson's disease." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT2252/document.

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La maladie de Parkinson (MP) est caractérisée par une dégénérescence des neurones dopaminergiques de la voie nigrostriée. La thérapie cellulaire, par transplantation intranigrale de cellules fœtales issues de mésencéphale ventral (MV), assure un rétablissement anatomique et fonctionnel de cette voie. Des molécules de guidage axonal (MGA) joueraient ainsi un rôle dans la reconnexion axonale des cellules transplantées. Pour tester cette hypothèse, nous avons étudié l'expression de MGA dans le cerveau adulte intact et dans des cellules destinées à la transplantation, ainsi que dans le cerveau adu

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10

Väyrynen, O. (Otto). "Factors affecting aggressive oral tongue cancer invasion and development of in vitro models for chemoradiotherapy assay." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526222813.

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Abstract Tumor associated macrophages (TAMs) are linked to the invasion of oral tongue squamous cell carcinoma (OTSCC). We modified THP-1 leukemia cells to M1 (inflammatory), M2 (TAM-like) and R848 (imidazoquinoline-treated) type macrophages in order to examine their interactions with OTSCC-cells (HSC-3) by using different kinds of in vitro migration and invasion models. We observed that interaction of TAM-resembling M2-type macrophages with HSC-3 cells induced invasion and migration, whereas the influence of M1 macrophages reduced them. Patient response to chemoradiotherapy is highly reliant

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11

Dinis, Tony Mickael. "Prothèse nerveuse artificielle à partir de fibroïne de soie pour la réparation et la régénération de nerfs périphériques." Thesis, Compiègne, 2014. http://www.theses.fr/2014COMP2152/document.

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La lésion de nerfs périphériques peut engendrer des déficits moteurs et/ou sensoriels permanents. En dépit des progrès techniques réalisés au cours de ces 25 dernières années, une récupération complète suite à ces lésions n’est pas encore possible aujourd'hui. L’autogreffe nerveuse, toujours considérée comme le standard clinique, est la seule technique capable d’offrir les meilleurs résultats en termes de récupération fonctionnelle. Cependant, la survenue de complications post-opératoires lors d’autogreffes d’un nerf et la quantité limitée de nerfs disponibles conduisent à mettre au point d’au

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12

Meng, Weina. "Evaluation of a nanoparticle drug delivery vehicle in medulloblastoma and organotypic brain cell cultures." Thesis, University of Nottingham, 2006. http://eprints.nottingham.ac.uk/13933/.

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It has been widely reported that cell culture dimension and microenvironment influence cell proliferation, differentiation, and gene expression, which lead to different interactions between drug delivery systems and cells. The development in evaluation of drug delivery systems has reached the stage where investigations are now concentrating on intracellular uptake and subcellular localization of drug delivery systems.This thesis investigates the use of three-dimensional (3-D) tissue culture models to study how nanoparticles (NPs) may behave in vivo. Poly (glycerol-adipate) (PGA) NPs can degrad

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13

Patel, Leena Suman. "Functional changes in pyramidal neurons surviving an excitotoxic challenge in mouse organotypic slice cultures /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/10658.

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14

Charpentier, Gilles. "Etude d'un facteur testiculaire qui perturbe le developpement de l'ovaire du foetus de rat, in vitro." Paris 7, 1988. http://www.theses.fr/1988PA077032.

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15

Sygnecka, Katja. "Organotypic brain slice co-cultures of the dopaminergic system - A model for the identification of neuroregenerative substances and cell populations." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-188897.

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The development of new therapeutical approaches, devised to foster the regeneration of neuronal circuits after injury and/or in neurodegenerative diseases, is of great importance. The impairment of dopaminergic projections is especially severe, because these projections are involved in crucial brain functions such as motor control, reward and cognition. In the work presented here, organotypic brain slice co-cultures of (a) the mesostriatal and (b) the mesocortical dopaminergic projection systems consisting of tissue sections of the ventral tegmental area/substantia nigra (VTA/SN), in combinati

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16

Hopes, Marina. "Human Organotypic Retinal Cultures as a model of human retinal ganglion cell degeneration in glaucoma : effects of epigenetic regulation and mesenchymal stem cell derived growth factors." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/56815/.

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Purpose: Human Organotypic Retinal Cultures (HORCs) have been shown to be a useful experimental model to investigate retinal ganglion cell (RGC) fate in short term models of glaucomatous stress. The aim of the current work was to investigate the long-term fate of RGCs in HORCs and to develop culture conditions to promote the RGC survival. The potential neurotrophic effect of mesenchymal stem cell derived growth factors on the RGC survival was studied and the role of epigenetic regulation of retinal cell gene expression was examined. Methods: Quantitative real-time polymerase chain reaction (QR

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17

Aldarwesh, Amal. "Oxygen and glucose deprivation on human Müller cells (MIO-M1) and human organotypic retinal cultures (HORCs) in relation to glaucoma." Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/58555/.

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Purpose: The purpose of this research was to investigate the effect of glaucoma-related insults, specifically oxygen and/or glucose deprivation (OGD) on the survival and genes expression of human Müller cells (MIO-M1), and retinal ganglion cells (RGCs) using the human organotypic retinal culture (HORC) model. Methods: MIO-M1 cells and HORCs were exposed to different levels of OGD using a custom-built chamber to control oxygen levels. Cell survival was evaluated using MTS and LDH assays while RGC death in HORCs was investigated using NeuN immunohistochemistry and TUNEL-labelling. Expression of

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18

Zielinski, Catharina [Verfasser]. "Establishment of a cell-based anti-prion compound screen and analysis of host response to prion infection in cerebellar organotypic slice cultures / Catharina Zielinski." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1206246251/34.

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19

Niyadurupola, Nuwan. "The development of human organotypic retinal cultures for glaucoma research : P2X7 receptor stimulation and interleukin 1B regulation in relation to retinal ganglion cell death." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514354.

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20

Radic, Tijana Verfasser], Amparo [Gutachter] [Acker-Palmer, and Stephan Wolfgang [Gutachter] Schwarzacher. "Structural development of postnatally generated dentate granule cells in organotypic entorhino-hippocampal slice cultures / Tijana Radić ; Gutachter: Amparo Acker-Palmer, Stephan Wolfgang Schwarzacher." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2017. http://d-nb.info/1138705330/34.

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21

Müller, Daniel [Verfasser], and Elmar [Akademischer Betreuer] Heinzle. "Organotypic functional cultures of human liver cells for long-term maintenance and assessment of drug-induced metabolome effects / Daniel Müller. Betreuer: Elmar Heinzle." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052338445/34.

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22

Sygnecka, Katja [Verfasser], Andrea [Akademischer Betreuer] Robitzki, Andrea [Gutachter] Robitzki, and Bernd [Gutachter] Heimrich. "Organotypic brain slice co-cultures of the dopaminergic system - A model for the identification of neuroregenerative substances and cell populations / Katja Sygnecka ; Gutachter: Andrea Robitzki, Bernd Heimrich ; Betreuer: Andrea Robitzki." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1239740050/34.

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23

Morel, Frédéric. "Etude experimentale du controle d'une famille de proteines de secretion d'un organe androgeno-dependant : l'epididyme de lezard." Clermont-Ferrand 2, 1987. http://www.theses.fr/1987CLF21074.

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24

Vidović, Natascha [Verfasser], and Richard [Akademischer Betreuer] Dodel. "Investigating the role of glial cells in neurodegenerative disorders by depleting astrocytes and oligodendrocytes in a model of amyloid-beta induced cytotoxicity in organotypic hippocampal slice cultures / Natascha Vidovic ; Betreuer: Richard Dodel." Marburg : Philipps-Universität Marburg, 2021. http://d-nb.info/1235139328/34.

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25

Couteaudier, Mathilde. "Réplication, dissémination et morphogénèse du virus de la maladie de Marek en cellules différenciées vers le lignage peau." Thesis, Tours, 2015. http://www.theses.fr/2015TOUR4018/document.

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Le virus de la maladie de Marek (MDV) est un alpha-herpesvirus responsable de lymphomes T mortels chez la poule. La peau et en particulier le follicule plumeux est considéré comme le seul site de production de particules virales extracellulaires et est à l'origine de la dissémination horizontale du virus et de la contamination de l'environnement. Cependant, aucun système cellulaire ne permet de reproduire ce qui se passe dans ce tissu. Le but de ma thèse a donc été de développer de nouveaux systèmes de culture permettant de reproduire la réplication, la morphogenèse et l’excrétion décrites in

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26

Chou, Ying-Tsen, and 周映岑. "Cell proliferation and differentiation of cervical epithelium in organotypic culture." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/36752981443168647659.

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碩士<br>國立成功大學<br>生理學研究所<br>97<br>The exocervix is composed of squamous epithelium and stroma. It has been shown that rat cervical epithelium undergo cyclic proliferation, differentiation and stratification during estrous cycle. Ectocervical epithelial cells cultured with fibroblast feeder cells or supplemented with specific growth medium proliferate and differentiate to some extent. In organotypic culture, the tissue fragments are cultured on sponge in air-liquid surface. Previous studies show that the stratified structure of exocervix in organotypic culture with 10 % fetal calf serum resembled

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27

"Investigations into Mechanisms of Tumor Cell Morphogenesis using a Three-Dimensional Organotypic Culture Model." Tulane University, 2018.

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28

Tran, Tuyet Thi Bach. "Studies of cell death in Parkinson’s disease using organotypic cell cultures." 2008. http://hdl.handle.net/2440/50424.

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In this study we aimed to investigate the effects of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) and rotenone neurotoxins on dopaminergic (DAergic) neuronal survival using ventral mesencephalic (VM) organotypic cell culture derived from postnatal rat pups (P4-5) and immunocytochemistry for tyrosine hydroxylase (TH) as a marker of DAergic cells. In addition, we examined the neuroprotective effects of glial cell line-derived neurotrophic factor (GDNF) on TH-ir cells exposed to MPTP and rotenone as a possible treatment for PD. The TH-ir cells in co-cultures with striatum (ST) as a target

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29

"Neuronal reorganization and glial neuroimmune responses to injury in organotypic slice cultures of neonatal mouse hippocampus." Tulane University, 1996.

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The hippocampal organotypic slice culture was used to study injury in the CNS. Studies characterized factors that influenced regenerative events in the hippocampal dentate gyrus, concomitant changes in glial cell populations, and examined the role of neuroglia in repair of damaged neural tissues Deafferentation of the hippocampus causes dentate granule cell axons, known as the mossy fibers, to initiate collateral neurite sprouting. Following axonal degeneration, mossy fibers form collaterals that invade the dental molecular layer, which contains denervated granule cell dendrites (Zimmer and Ga

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30

Morais, Hermes Manuel Medina. "Development of secretome-based therapy by motor neuron modulation of miRNA-124 in ALS mouse models." Master's thesis, 2020. http://hdl.handle.net/10362/111128.

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Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by the degeneration of upper (cortical) and lower (spinal cord, SC) motor neurons (MNs) and aberrancy of glial cells. Results from our group point to a close connection between increased levels of miRNA-124 and the acquisition of pathological characteristics in MNs, astrocytes and microglia in ALS. Our main aim was to validate if the downregulation of the elevated levels of miR-124 in hSOD1G93A (mSOD1) MNs toward normal levels was preventive over neurodegeneration, astrocyte aberrancies and microglia activation in the mSOD1

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