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Journal articles on the topic 'Ornidazole'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Marcus, Yehouda, Noam Tal, Mordechai Ronen, Raanan Carmieli, and Michael Gurevitz. "The drug ornidazole inhibits photosynthesis in a different mechanism described for protozoa and anaerobic bacteria." Biochemical Journal 473, no. 23 (2016): 4413–26. http://dx.doi.org/10.1042/bcj20160433.

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Ornidazole of the 5-nitroimidazole drug family is used to treat protozoan and anaerobic bacterial infections via a mechanism that involves preactivation by reduction of the nitro group, and production of toxic derivatives and radicals. Metronidazole, another drug family member, has been suggested to affect photosynthesis by draining electrons from the electron carrier ferredoxin, thus inhibiting NADP+ reduction and stimulating radical and peroxide production. Here we show, however, that ornidazole inhibits photosynthesis via a different mechanism. While having a minute effect on the photosynth

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2

Dmytro, Leontiev, Bevz Olena, Volovyk Natalia, Gella Ivan, and Georgiyants Victoria. "The synthesis and study of profiles of the ornidazole impurities." ScienceRise: Pharmaceutical Science, no. 1(11) (February 28, 2018): 4–11. https://doi.org/10.15587/2519-4852.2018.123387.

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Pharmacopoeial reference standards (PhRSs) provide the comparability of the test results of generic drugs. PhRSs of ornidazole impurities are not described in pharmacopoeias. Therefore, the establishment of PhRSs of the State Pharmacopeia of Ukraine (SPhU RSs) of ornidazole impurities is an essential task, the integral part of which is synthesis and characterisation of ornidazole impurities. <strong>Aim:</strong> To synthesise impurities of ornidazole as candidate materials for certification as SPhU RSs and study their profiles in the substance and infusion solution of ornidazole. <strong

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1393 (2012): 32. http://dx.doi.org/10.2165/00128415-201213930-00112.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1186 (2008): 29. http://dx.doi.org/10.2165/00128415-200811860-00091.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1356 (2011): 28. http://dx.doi.org/10.2165/00128415-201113560-00097.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1369 (2011): 30. http://dx.doi.org/10.2165/00128415-201113690-00108.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1407 (2012): 32. http://dx.doi.org/10.2165/00128415-201214070-00114.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1411 (2012): 33. http://dx.doi.org/10.2165/00128415-201214110-00119.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1414 (2012): 40–41. http://dx.doi.org/10.2165/00128415-201214140-00138.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1086 (2006): 17. http://dx.doi.org/10.2165/00128415-200610860-00052.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 864 (2001): 10. http://dx.doi.org/10.2165/00128415-200108640-00025.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 906 (2002): 9. http://dx.doi.org/10.2165/00128415-200209060-00025.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 937 (2003): 12. http://dx.doi.org/10.2165/00128415-200309370-00055.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1311 (2010): 33. http://dx.doi.org/10.2165/00128415-201013110-00115.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 992 (2004): 11. http://dx.doi.org/10.2165/00128415-200409920-00030.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1300 (2010): 37. http://dx.doi.org/10.2165/00128415-201013000-00123.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1301 (2010): 39. http://dx.doi.org/10.2165/00128415-201013010-00139.

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&NA;. "Ornidazole." Reactions Weekly &NA;, no. 1336 (2011): 36. http://dx.doi.org/10.2165/00128415-201113360-00115.

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19

ZUHRI, ALI Z. ABU, WOLFGANG VOELTER, SULEIMAN AL-KHALIL, and IMAD SALAHAT. "Extractional - Spectrophotometric Determination of Fenbendazole and Ornidazole in Pharmaceutical Formulations." Scientia Pharmaceutica 68, no. 1 (2000): 109–22. http://dx.doi.org/10.3797/scipharm.aut-00-10.

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Methods for spectrophotometric determination of fenbendazole and ornidazde are described. The methods are based on the formation and extraction of the ion-pair complex formed between bromothymol blue and either fenbendazole (FBZ) or ornidazole (ORN). The extracted coloured complexes absorb at 416 and 446 nm, respectively. The effect of different factors, e.g. pH, organic solvent, reagent concentration, extraction time, shaking time and common interfering species have been investigated. Fenbendazole and ornidazole can be determined over the range 1.2 to 24.0 ppm and 5.5 to 77.0 ppm, respectivel

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20

Kant Gupta, Krishan, Abhay Bhardwaj, Anuj Pathak, N. G. Raghavendra Rao, and Surya Prakash. "A Review on Analytical and Pharmacological Description of Ornidazole." Journal of Neonatal Surgery 14, no. 7 (2025): 1138–45. https://doi.org/10.63682/jns.v14i7.7289.

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Ornidazole is a well-known Anti-bacterial drug associated with the Nitroimidazole class. It’s a class II BCS compound with poor solubility in inorganic solvents. Hoffmann-La-Roche synthesized orinidazole in 1966. Anaerobic bacteria are susceptible to the antibacterial and antiprotozoal effect of ornidazole. This review mainly focuses on various analytical estimations techniques of ornidazole and compares it with other drug compounds. This is a comprehensive review of previous research on the drug ornidazole

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21

&NA;. "Metronidazole/ornidazole." Reactions Weekly &NA;, no. 874 (2001): 10. http://dx.doi.org/10.2165/00128415-200108740-00032.

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22

&NA;. "Metronidazole/ornidazole." Reactions Weekly &NA;, no. 1258 (2009): 23. http://dx.doi.org/10.2165/00128415-200912580-00077.

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23

&NA;. "Doxycycline/ornidazole." Reactions Weekly &NA;, no. 1334 (2011): 22. http://dx.doi.org/10.2165/00128415-201113340-00078.

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24

Deng, Liping, Wei Wang, and Jianguo Lv. "Ornidazole hemihydrate." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (2007): o4204. http://dx.doi.org/10.1107/s1600536807045680.

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The asymmetric unit of the racemic title compound, C7H10ClN3O3·0.5H2O, has two independent molecules of ornidazole. The crystal structure is formed via intermolecular hydrogen bonds involving the water molecules.

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25

Li, Sichan, Ming Cao, Yan Zhou, Chang Shu, and Yang Wang. "Ornidazole Transfer into Colostrum and Assessment of Exposure Risk for Breastfeeding Infant: A Population Pharmacokinetic Analysis." Pharmaceutics 15, no. 11 (2023): 2524. http://dx.doi.org/10.3390/pharmaceutics15112524.

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Ornidazole is frequently used for the prevention and treatment of anaerobic infections after caesarean section. There is still a lack of data on the excretion of ornidazole in breast milk. Therefore, the aim of this study was to investigate the transfer of ornidazole into colostrum and to assess the risk of infant exposure to the drug via breast milk. Population pharmacokinetic analysis was conducted using datasets of plasma and milk concentrations obtained from 77 breastfeeding women to examine the excretion kinetics of ornidazole. Various factors that may affect the excretion of ornidazole w

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26

Apolikhina, I. A., and D. S. Makovskaya. "Infectious and Inflammatory Diseases of the Female Genital Organs: a Course Towards Rational Antimicrobial and Antiprotozoal Therapy." Doctor.Ru 22, no. 5 (2023): 101–4. http://dx.doi.org/10.31550/1727-2378-2023-22-5-101-104.

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Aim: to provide the key trends in the use of a modern combined medicinal product of ciprofloxacin and ornidazole. Key points. The product has a combined antimicrobial and antiprotozoal effect; its pharmacological action is a result of the properties of the active ingredients — ciprofloxacin and ornidazole. The article describes the efficacy of this combination against gynaecological infections. Conclusion. The use of the ciprofloxacin and ornidazole combination demonstrates therapeutic effect against a majority of urinogenital gynaecological conditions. The product is beneficial in case of con

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27

Kumar, Basant. "Analytical Method Development and Validation of Ornidazole in Bulk and Dosage Form." International Journal for Research in Applied Science and Engineering Technology 11, no. 6 (2023): 1754–59. http://dx.doi.org/10.22214/ijraset.2023.53934.

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Abstract: In the given study, of an For the purpose of estimating ornidazole in bulk and dose form, an correct, exact, and specific approach has been established. by ultraviolet spectroscopy. Ornidazole belongs to the categories of antibacterial medications ( nitroimidazoles) also used to treat infections caused by anaerobic bacteria and protozoa. The procedure includes calculation of the absorbance of Ornidazole blend in Methanol water 1:9. The calibration curve method shows wavelength maxima for Ornidazole at 315 nm with Methanol water 1:9 in the wavelength having a correlation value of 0.99

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28

Maltaş Çağıl, Esra. "Detection of interaction between ornidazole and albumin by using thermodynamic parameters." International Journal of Advanced Chemistry 9, no. 2 (2021): 161. http://dx.doi.org/10.14419/ijac.v9i2.31798.

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The binding of 1-chloro-3-(2-methyl-5-nitro-1H-imidazole-1-yl) propan-2-ol (Ornidazole) to human serum albumin (HSA) was studied by fluorescence and UV-visible spectroscopy. Interaction of ornidazole (OR) with HSA was identified by Stern-Volmer and Van’t Hoff equations. The binding constant, Kb and the thermodynamic parameters, ∆H, ∆S, and ∆G at different temperatures were calculated by several equations. Data shows that the fluorescence quenching mechanism of HSA with ornidazole may occur via static quenching. The thermodynamic parameters showed that van der Waals interactions and hydrogen bo

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29

Ambadas, Ranganath Rote, and Ravindranath Bhanudas Saudagar. "New Analytical Method Development and Validation of Ciprofloxacin and Ornidazole in Human Plasma by High Performance Thin Layer Chromatography." Pharmaceutical Methods 7, no. 2 (2016): 89–93. https://doi.org/10.5281/zenodo.14858032.

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Objective: The objective of the method was to develop a simple, rapid, sensitive, selective and economic high performance thin layer chromatographic method for simultaneous determination of ciprofloxacin and ornidazole in human plasma by using tinidazole as an internal standard. Method: The plasma sample was extracted using methanol: formic acid (5.5:0.5 v/v) and known amount of extract was spotted on precoated silica gel 60 F254 plates using Camag Linomat V auto sampler. A concentration range from 100–700 ng/spot for both drugs was used for calibration curve. The percent recoveries of C

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30

Barwa, Tara N., Daniele Alves, Yiran Luo, Eithne Dempsey, and Carmel B. Breslin. "A WS2/CNF Nanocomposite for Electrochemical Sensing Applications." ECS Transactions 113, no. 12 (2024): 11–18. http://dx.doi.org/10.1149/11312.0011ecst.

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It is well recognized that antimicrobials are central to society, but they have also entered the aquatic environment posing risks to public health and our essential ecosystems. Therefore, the detection of antimicrobial drugs at low concentration levels in aquatic environments is essential. In this study, a new composite comprising tannic acid modified carbon nanofibers (CNFs) and WS2 was formed to give CNF/WS2 and used in the electrochemical detection of ornidazole, an antimicrobial drug. Ornidazole is a well-known nitroimidazole and it has been detected in various water bodies. Using the CNF/

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31

Fonseca, J. M. López, M. C. Gómez Rivera, and J. C. García Monteagudo. "Electrochemistry of Ornidazole." Analytical Letters 26, no. 1 (1993): 109–24. http://dx.doi.org/10.1080/00032719308016799.

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32

Buxeraud, Jacques. "Tibéral® - ornidazole." Actualités Pharmaceutiques 47, no. 479 (2008): 53–54. http://dx.doi.org/10.1016/s0515-3700(08)70072-7.

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33

Murugesan, Sakthibalan, Gerard Marshall Raj, and Mangaiarkkarasi Adhimoolam. "Cefixime and ornidazole combination induced fixed drug eruption: a case report." International Journal of Basic & Clinical Pharmacology 9, no. 1 (2019): 211. http://dx.doi.org/10.18203/2319-2003.ijbcp20195789.

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Cefixime, a third generation cephalosporin and ornidazole, a nitroimidazole is used for a wide variety of conditions like urinary tract infections, otitis media, pharyngitis, uncomplicated gonorrhea and anaerobic infections. Fixed drug eruption (FDE) is commonly associated with anticonvulsants, antimicrobials and NSAIDs. Here we report a case of a rare cefixime and ornidazole combination induced fixed drug eruption. A 39 year old male developed hyper-pigmented patches over both forearms and left thigh after consuming fixed dose combination of cefixime and ornidazole tablet for the treatment of

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34

Menezes, Cylma, Varun G, Shyamkumar B, and Reema N. "Development of RP-HPLC Method for the Quantitative Estimation of Ofloxacin and Ornidazole in Combined Liquid Oral Dosage Forms." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 1 (2013): 1972–76. http://dx.doi.org/10.37285/ijpsn.2013.6.1.8.

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A simple, efficient and reproducible reversed phase high performance liquid chromatographic (RP-HPLC) method for the quantitative estimation of ofloxacin and ornidazole in bulk and in combined liquid oral dosage form has been developed and validated. The separation was carried out using thermohypersil phenyl column (250 mm × 4.6 mm, 5 μm) as stationary phase with isocratic flow and phosphate buffer (adjusted to pH 2.4 with ortho phosphoric acid): acetonitrile (87:13 v/v) as mobile phase. Mobile phase was maintained at a flow rate of 1.0 ml/min and UV detection was carried out at 294 nm. The re

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35

COOPER, TREVOR G., CHING‐HEI YEUNG, ROLF SKUPIN, and GÜNTER HAUFE. "Antifertility Potential of Ornidazole Analogues in Rats." Journal of Andrology 18, no. 4 (1997): 431–38. http://dx.doi.org/10.1002/j.1939-4640.1997.tb01949.x.

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ABSTRACT: In order to determine which part of the ornidazole molecule [1‐(3‐chloro‐2‐hydroxy)propyhl‐2‐methyl‐5‐nitroimidazole] is responsible for its antifertility action, structural analogues were fed to male rats of proven fertility at doses equivalent to the antifertility dose of ornidazole (1.82 mmol/kg/day). The fertility of the males was tested, before oral gavage (control mating) and after 10 and 14 days of feeding, by counting the number of fetuses and corpora lutea present in females 12 days after mating. The day after the last mating, the kinematic parameters of sperm from the cauda

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36

Pyka-Pająk, Alina. "TLC–Densitometric Analysis of Selected 5-Nitroimidazoles." Processes 11, no. 1 (2023): 170. http://dx.doi.org/10.3390/pr11010170.

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Metronidazole, ornidazole, tinidazole, and secnidazole are 5-nitroimidazoles. The purpose of this work was to propose a new economical TLC–densitometric method to evaluate the chemical stability of metronidazole, secnidazole, ornidazole, and tinidazole under stress conditions. A forced degradation study was performed on silica gel and aqueous solutions at various pH values; the metronidazole, secnidazole, ornidazole, and tinidazole solutions were prepared in saline and in hydrogen peroxide, respectively. The samples of the 5-nitroimidazoles were heated. TLC analyses were performed on silica ge

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37

Ramya Nagabathula, Devi Priya K, Pujitha A S D, Mohan Kumari B, Surendra P, and Jyothi T. "Development and Validation of a UV-Spectrophotometric Method for Simultaneous Quantification of Ofloxacin and Ornidazole in Pharmaceutical Formulations." Journal of Pharma Insights and Research 3, no. 2 (2025): 280–86. https://doi.org/10.69613/h4070n95.

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A simple, rapid, and cost-effective UV-spectrophotometric method was developed and validated for simultaneous determination of Ofloxacin and Ornidazole in combined tablet formulations. The method utilized maximum absorption wavelengths of 294 nm for Ofloxacin and 319 nm for Ornidazole in a solvent system consisting of 0.1N acetic acid and water (10:90 v/v). The developed method had excellent linearity in the concentration range of 10-50 µg/mL for both drugs, with correlation coefficients of 0.9998 and 0.9999 for Ofloxacin and Ornidazole, respectively. Method validation following ICH guidelines

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38

Du, Ruobing, Kai Ba, Yaxin Yang, Yueyue Zhao, and Yupeng Lin. "Efficacy of ornidazole for pericoronitis: a meta-analysis and systematic review." Archives of Medical Science 20, no. 1 (2024): 189–95. http://dx.doi.org/10.5114/aoms/171907.

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IntroductionTimely and effective treatments of pericoronitis are very important. We aimed to evaluate the role of ornidazole in the treatment of pericoronitis, to provide insights for clinical pericoronitis treatment.Material and methodsThe PubMed, Clinical trials, EMBASE, Science Direct, Cochrane Library, China National Knowledge Infrastructure (CNKI), Weipu and Wanfang databases were searched to find randomized controlled trials (RCTs) of ornidazole in the treatment of pericoronitis from the establishment of the database to March 15, 2023. Review Manager 5.3 software was used for meta-analys

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Balamurugan, R., Phulen Sarma, Prabhakaran Nagendran, Deepthi Slesser Nicodemus, and Sushil Sharma. "A simple patch test (empty tablet cover patch test) demonstrating ornidazole as offending agent in a patient of fixed drug eruption: Report of a clinical case, a new modified technique and systematic review of literature." Indian Journal of Pharmacology 57, no. 3 (2025): 179–86. https://doi.org/10.4103/ijp.ijp_708_22.

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A 49-year-old male presented with the complaints of sudden-onset redness and watering of both the eyes following the intake of fixed drug combination of ofloxacin–ornidazole for diarrhea. Following this, he developed redness of both the lips and blisters in the upper lip. He also developed erythematous macules in the medial aspects of the right lower thigh and ventral aspects of the right leg. Ocular examination showed conjunctival redness with diffuse corneal punctate epithelial erosions in both the eyes. The patient had a similar history affecting the same region 1 year back following the in

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40

Huang, Zhengmei, Shenchun Wang, Ningtao Wang, et al. "Preparation and evaluation of PCLA2575 membranes loaded ornidazole in vitro." Journal of Bioactive and Compatible Polymers 32, no. 6 (2017): 615–27. http://dx.doi.org/10.1177/0883911517693636.

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The aim of this study was to evaluate the properties of the sustained release and antibacterial activity of the ornidazole-drug-loaded membranes using poly[(ethylene glycol)-caprolactone-lactide] (PCLA2575) as membrane material. Ornidazole-loaded membranes were prepared by solvent casting method with the proportion of 5 wt%, 8 wt%, and 10 wt%, respectively. In vitro drug release properties were determined by ultraviolet spectrophotometric method. The antibacterial activities against Streptococcus mutans and Fusobacterium nucleatum in vitro were observed on solid culture medium. The membrane ha

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41

Huang, Jianquan, Guoying Cao, Xin Hu, Chunhua Sun, and Junren Zhang. "Chiral separation ofrac-Ornidazole and detection of the impurity of (R)-Ornidazole in (S)-Ornidazole injection and raw material." Chirality 18, no. 8 (2006): 587–91. http://dx.doi.org/10.1002/chir.20292.

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42

Panggabean, Amer, Adi Sutjipto, Dachrul Aldy, A. H. Sutanto, and Helena Siregar. "Tinidazole versus Ornidazole in Amebic Dysentery in Children (a double blind trial)." Paediatrica Indonesiana 20, no. 11-12 (2021): 229–35. http://dx.doi.org/10.14238/pi20.11-12.1980.229-35.

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Between January and June 1978, a double blind trial was conducted in 3.5 children, suffering from Amebic Dysentery in the OPD of the General Hospital Medan. The children were treated ambulatory, either with Tinidazole or Ornidazole, with a dose of 50 mg/kg body weight/day for 3 consecutive days, under close supervision. All the children, except on in the Tinidazole group (case no. 20), gave excellent responses. Disappearance of ameba's blood and mucus from the stools occurred in all of the patients after 2 days of treatment. There was no significant difference in the results of tre

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43

Jerubin Welsingh, M., R. Xavier Arulappa, and V. Shankarananth. "Analytical method development and validation of ornidazole by using uv spectroscopy." Current Trends in Pharmacy and Pharmaceutical Chemistry 6, no. 1 (2024): 18–22. http://dx.doi.org/10.18231/j.ctppc.2024.004.

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The present research work discusses the development and validation of a UV spectrophotometric method for ornidazole. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of ornidazole in pure drug form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λ max) was found to be 430 nm. Beers law was obeyed in the concentration range of 1μg/mL. Calibration curves shows a linear relationship between the absorbance and concentration. Validation was performed according to ICH guidelines for Linearity, accuracy,

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44

Jose, Preetha, Narayanan P. V., and Varghese Thomas. "A randomised double blind placebo controlled trial to assess the efficacy and tolerability of short course of ornidazole in diarrhoea predominant irritable bowel syndrome." International Journal of Basic & Clinical Pharmacology 7, no. 11 (2018): 2086. http://dx.doi.org/10.18203/2319-2003.ijbcp20184315.

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Background: Irritable bowel syndrome is a common disorder affecting the general population. At present the treatment is mainly symptomatic as the pathophysiology is not clear. Abnormal flora especially small bowel bacterial over growth is considered as one of the causes. A short course of ornidazole is compared with placebo to assess its efficacy and tolerability in diarrhoea predominant irritable bowel syndrome.Methods: This was a randomised double-blind placebo controlled trial done in the Departments of Gastroenterology and Pharmacology at Government Medical College, Calicut. Patients were

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45

ERSOZ, Galip, Rukiye VARDAR, Ulus Salih AKARCA, et al. "Ornidazole-induced autoimmune hepatitis." Turkish Journal of Gastroenterology 22, no. 5 (2011): 494–99. http://dx.doi.org/10.4318/tjg.2011.0245.

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Koşar, Y., N. Şaşmaz, P. Oguz, et al. "Ornidazole-induced autoimmune hepatitis." European Journal of Gastroenterology & Hepatology 13, no. 6 (2001): 737–39. http://dx.doi.org/10.1097/00042737-200106000-00022.

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47

B., H. M. Mruthyunjayaswamy, M. Mali Patil S., and Appala Raju S. "Spectrophotometric determination of ornidazole." Journal of Indian Chemical Society Vol. 81, Apr 2004 (2004): 346–48. https://doi.org/10.5281/zenodo.5832501.

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Department of Chemistry, Gulbarga University, Gulbarga-585 106, India <em>E-mail</em> : bhmmswamy@rediffmail.com H. K. E. S.'s College of Pharmacy, Gulbarga-585 105, India <em>Manuscript received 14 January 2003, revised 4 August 2003, accepted 29 September 2003</em> Three simple, sensitive, selective and economical methods (method A, B and C) for the determination of ornidazole have been described. Method A, B and C are based on the formation of yellow, blood red and blue coloured chromogens when reduced ornidazole <em>in situ</em> reacted with vanillin, 1,10-phenanthroline in presen

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48

V., Vane Vaishnavi, Prof Patil N., and Dr Megha T. Salve. "Formulation And Evaluation Of Ornidazole Topical." International Journal of Research Publication and Reviews 6, no. 5 (2025): 13499–503. https://doi.org/10.55248/gengpi.6.0525.1927.

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49

Özgöztaşı, Orhan. "Topical Ornidazole Therapy tor Rosacea." European Journal of Therapeutics 1, no. 1 (1990): 16–22. http://dx.doi.org/10.58600/eurjther.19900101-459.

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In this a double-blind study, 17 patients wıth rosacea were treated topically with% 1 ornidazole cream. The other group of 9 patients with rosacea received place-bo cream. Applications were performed twice daily and treatment results were evaluated after one month. The cream was locally well tolerated and no systemic symptoms were noted. Topical ornidazole cream therapy appears to be a safe and efficacious therapy in the treatment of rosacea.

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50

Babina, Yu M., O. A. Nazarchuk, and D. V. Dmytriiev. "Use of ornidazole in the treatment of anaerobic infection in surgery." Perioperaciina Medicina 3, no. 2 (2021): 17–23. http://dx.doi.org/10.31636/prmd.v3i2.3.

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One of the most complex problems of modern surgery is the treatment and prevention of anaerobic infection. Main place in overcoming of this infectious complication is devoted to urgent surgical intervention and correct early empiric antibacterial therapy. Special place in the combined empiric antibacterial treatment is devoted to 5-nitroimidazoles. Modern data about clinical efficacy of ornidazole in the treatment of surgical infectious complications is presented in the article. We performed a comparison of therapeutic activity and physical-chemical properties, pharmacokinetic and pharmacodyna

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