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Dissertations / Theses on the topic 'Ornithine Ornithine decarboxylase'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Lövkvist, Wallström Eva. "On the regulation of ornithine decarboxylase." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945009.html.

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2

Kern, Andrew David. "Structure of ornithine decarboxylase from mouse /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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3

De, Villiers Jandré. "Attempted routes towards the synthesis of fluorinated analogues of ornithine as potential inhibitors of ornithine decarboxylase /." Link to the online version, 2007. http://hdl.handle.net/10019/417.

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4

Parsanejad, Reza. "Phosphoenolpyruvate carboxykinase and ornithine decarboxylase genes : allelic variations and associations with traits in poultry." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84307.

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The objectives of this study were to identify genetic variants, develop the respective haplotypes (combination of alleles) and investigate the association of identified variants with economically important traits in two candidate genes. The first gene was Phosphoenolpyruvate carboxykinase (PEPCK) which is a key regulatory enzyme of gluconeogenesis. The second candidate gene, Ornithine decarboxylase (ODC), is a rate-limiting enzyme in polyamine biosynthesis. It has a significant role in DNA synthesis and cell proliferation. We first analyzed the genetic variability of PEPCK-C, the gene w

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5

Chu, Yi-wen 1962. "Amino acid sequence requirements for ornithine decarboxylase activity." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276838.

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ODC activity of the altered proteins was measured and compared to that of the full length 461 amino acid containing ODC. Mouse ODC cDNA sequences were deleted from either 5' or 3' ends using exonuclease III and Mung Bean nuclease treatments. An internal deletion was obtained by Hinc II and Bcl I restriction endonuclease digestion of the full length ODC cDNA. Capped mRNAs were synthesized in vitro using the resulting deleted DNA as templates, and the protein was translated in vitro. The results indicate that the protein in which translation initiates at internal AUG start codons does not have a

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6

Tome, Margaret Ellen. "Cellular and biochemical consequences of ornithine decarboxylase regulation." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/282137.

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The polyamines are abundant polycations necessary for eucaryotic cell growth. Ornithine decarboxylase (ODC), the first and often rate-limiting enzyme in polyamine biosynthesis, is responsible for the formation of putrescine, the precursor for polyamine synthesis. ODC is normally very tightly regulated by a complex interaction of control of both synthesis and degradation. Regulation of ODC synthesis allows cells to increase ODC in response to various stimuli; however, the importance of the rapid degradation of ODC in cellular metabolism is less well understood. The studies presented here have c

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7

De, Villiers Jandre. "Attempted routes towards the synthesis of fluorinated analogues of ornithine as potential inhibitors of ornithine decarboxylase." Thesis, Stellenbosch : University of Stellenbosch, 2007. http://hdl.handle.net/10019.1/3096.

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Thesis (MSc (Chemistry and Polymer Science))--University of Stellenbosch, 2007.<br>Human African Trypanosomiasis (HAT) is a disease that threatens more then 60 million men, woman and children in Africa. It is known that the inhibition of the enzyme, ornithine decarboxylase (ODC) leads to cell arrest and subsequent death of Trypanosoma brucei, the parasite that causes the disease. The fluorinated ornithine analogue, DFMO (difluoromethylornithine or eflornithine) is a known inhibitor of ODC. Although various syntheses for DFMO exist they have some practical drawbacks which prevent the cost

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8

Nancarrow, Michelle Jane. "The role of polyamines in cellular and molecular events in the wool follicle." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phn1756.pdf.

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Bibliography: leaves 255-280. In vivo and in vitro investigations of the hypothesis that polyamines and their synthetic enzymes have a role in regulation of cellular and molecular processes in the follicle. The activity of ornithine decarboxylase (ODC), the rate limiting polyamine biosynthetic enzyme, is demonstrated in wool follicle homogenates.

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9

Laitinen, Päivi. "Antizyme in the regulation of mouse brain ornithine decarboxylase." Oulu : University of Oulu, 1986. http://catalog.hathitrust.org/api/volumes/oclc/16882622.html.

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10

Zhang, Ling 1962. "Molecular cloning and characterization of the chicken ornithine decarboxylase gene." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22831.

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Ornithine decarboxylase (ODC) is the rate determining enzyme in the biosynthesis of polyamines which are essential for cell growth. In chickens, significantly higher bioactivity is reported in broiler than in egg layer strains of chickens (Bulfield et al., 1988). To characterize the genetic differences in growth rates and ODC levels in chickens, an ODC cDNA and genomic gene were cloned and sequenced. Sequencing of ODC cDNA revealed that this clone (pODZ3: 2,052 bp) was not a full length of ODC cDNA and contained 2 putative introns. The open reading frame (introns deleted) coded for a protein o

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11

Mueller, Elisabeth. "Cloning and functional characterisation of ornithine decarboxylase of Tapesia yallundae." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311344.

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12

Johnson, Ruth. "The biochemical and molecular genetics of ornithine decarboxylase in chickens." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/15106.

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The role of ornithine decarboxylase (ODC) was investigated in muscle and embryos of different chicken lines selected and unselected for increased growth and weight-for-age. Both lines showed a peak in muscle ODC activity at 5-6 days post hatch which can be up to 4-fold higher in the selected line. Use of α-difluoromethylornithine (DFMO) to try to inhibit this activity in the selected line produced birds which had significantly lower body weight, but not muscle weight or muscle ODC activity, than control birds. It seems that treatment may have been started too late (4 days post-hatch) to have a

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13

Yao, Jianbo. "Molecular cloning of the bovine ornithine decarboxylase gene and the detection of trait-associated DNA polymorphisms in the bovine ornithine decarboxylase and growth hormone genes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq30422.pdf.

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14

Nilsson, Tatjana. "Amyloid precursor protein: cellular studies and animal models /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-832-0/.

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15

O'Sullivan, Dan. "The catabolism of arginine and ornithine in the liver." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0017/NQ54840.pdf.

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16

GLASS, JAMES RUSSELL. "POLYAMINE-MEDIATED DEGRADATION OF ORNITHINE DECARBOXYLASE IN CHINESE HAMSTER OVARY CELLS." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184002.

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The objective of this research was to identify specific mechanisms involved in the regulation of ornithine decarboxylase, the first enzyme in the polyamine biosynthetic pathway. Immunochemical techniques were used to study post-translational modifications of the ODC protein in relation to activity alterations. Initial experimentation showed that Chinese hamster cells maintained in a defined medium express an ODC protein stable to intracellular degradation. Treatment of these cells with exogenous ornithine or polyamines resulted in a rapid loss of enzyme activity, without detectable changes in

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17

Reynolds, Jonathan James. "Structure-based drug discovery against a novel antimalarial drug target, S-adenosylmethionine decarboxylase/ornithine decarboxylase." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/27172.

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Malaria is one of the most life-threatening diseases affecting mankind, with over 3 billion people being at risk of infection, with most of these people living in Africa, South America and Asia. As the malaria parasite is rapidly becoming resistant to many of the possible treatments on the market, it is of upmost importance to identify new possible drug targets and describe drugs against these that are inexpensive, easy to manufacture and have a long shelf-life in order to combat malaria. One such target is the polyamine pathway. The polyamines putrescine, spermidine, and spermine are crucial

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18

Pong, Nga Hin. "The role of calcium in control of animal cell proliferation : ornithine decarboxylase induction by L-asparagine in Reuber H-35 hepatoma cell." HKBU Institutional Repository, 1991. https://repository.hkbu.edu.hk/etd_ra/1.

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19

Niemand, Jandeli. "A phage display study of interacting peptide binding partners of malarial S-Adenosylmethionine decarboxylase/Ornithine decarboxylase." Diss., University of Pretoria, 2007. http://hdl.handle.net/2263/24105.

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Due to the increasing resistance against the currently used antimalarial drugs, novel chemotherapeutic agents that target new metabolic pathways for the treatment of malarial infections are urgently needed. One approach to the drug discovery process is to use interaction analysis to find proteins that are involved in a specific metabolic pathway that has been identified as a drug target. Protein-protein interactions in such a pathway can be preferential targets since a) there is often greater structural variability in protein-protein interfaces, which can lead to more effective differentiation

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20

Almrud, Jeffrey James. "Structural investigations of E. coli biosynthetic arginine decarboxylase, and crystal structure of human ornithine decarboxylase ar 2.1Å resolution /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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21

Van, Brummelen Anna Catharina. "Functional genomics analysis of the effects of co-inhibition of the malarial S-adenosylmethionine decarboxylase/ornithine decarboxylase." Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-05302009-124548.

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22

Van, Brummelen Anna Catharina. "Functional genomics analysis of the effects of co-inhibition of the malarial S-adenosylmethionine decarboxylase/ornithine decarboxylase." Thesis, University of Pretoria, 2008. http://hdl.handle.net/2263/25135.

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Polyamines are ubiquitous components of all living cells and their depletion usually causes growth arrest or cytostasis, a strategy employed for treatment of West-African trypanosomiasis. In the malaria parasite, Plasmodium falciparum, polyamine biosynthesis is regulated by the uniquely bifunctional protein, Sadenosylmethionine decarboxylase/ornithine decarboxylase (PfAdoMetDC/ODC). The unique nature of this protein could provide a selective mechanism for antimalarial treatment. To validate polyamine depletion and specifically PfAdoMetDC/ODC, as drug target for antimalarial therapeutic interve

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23

Zhao, Biwei. "A core promoter element mediates the induction of rat ornithine decarboxylase by TPA /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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24

Birkholtz, Lyn-Marie. "Molecular characterisation of the ornithine decarboxylase gene of the human malaria parasite, plasmidium falciparum." Diss., University of Pretoria, 1998. http://hdl.handle.net/2263/37299.

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Malaria is one of the most serious tropical infectious diseases affecting mankind. The prevention of the disease is hampered by the increasing resistance of the parasite to existing chemotherapy and -prophylaxis drugs. The need for novel therapeutic targets and drugs is therefore enormous and the understanding of the biochemistry of the parasite is imperative. The aim of this study was the identification and molecular characterisation of the eDNA of one such metabolic target protein, ornithine decarboxylase (ODC), in the human malaria parasite P. falciparum. The P. falciparum ODC eDNA w

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25

Hau, Kwok-po. "The role of calcium in the induction of ornithine decarboxylase by L-asparagine in Reuber H-35 rat hepatoma cells /." [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13458942.

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26

Lavergne, Christopher Leon Joseph. "Peri-Ovulatory Supplementation of L-Ornithine to Increase Reproductive Success in Aged Mice." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38341.

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In all mammalian species examined thus far, the ovaries produce a burst of ornithine decarboxylase (ODC) and putrescine during ovulation or after application of a bolus of human chorionic gonadotropin (hCG). Aged mice are deficient in this peri-ovulatory ODC and putrescine burst. Moreover, peri-ovulatory putrescine supplementation in aged mice increases egg quality and reduces miscarriage rates. These studies suggest that peri-ovulatory putrescine supplementation may be a simple and effective therapy for reproductive aging for women. However, putrescine has never been used in humans and, curr

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27

Beenukumar, Renukadevi Roshini [Verfasser], Jürgen [Akademischer Betreuer] Dohmen, and Kay [Akademischer Betreuer] Hofmann. "Ubiquitin-Independent Proteolytic Targeting of Ornithine Decarboxylase / Roshini Beenukumar Renukadevi. Gutachter: Jürgen Dohmen ; Kay Hofmann." Köln : Universitäts- und Stadtbibliothek Köln, 2015. http://d-nb.info/1078997810/34.

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28

Prieto, Jenaro Garcia-Huidobro. "Molecular and Functional Consequences of Genetic Variability in the Ornithine Decarboxylase Gene in Colorectal Cancer." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/312735.

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Dysregulation of cellular metabolism is associated with multiple diseases including cancer. Polyamines are organic cations shown to control gene expression at the transcriptional, post-transcriptional, and translational level. The activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is associated with normal and neoplastic growth. A single nucleotide polymorphism (SNP, rs2302615, SNP +316 nucleotides 3' of the transcriptional start site) in the ODC1 gene has been found to be both functional and prognostic for risk of colorectal carcinogenesis. A comprehensive inv

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29

Peters-Weigel, Sandra M. "Regulation of the speC gene encoding ornithine decarboxylase in Escherichia coli by putrescine, spermidine and cAMP." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-08182009-040534/.

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30

侯國寶 and Kwok-po Hau. "The role of calcium in the induction of ornithine decarboxylase by L-asparagine in Reuber H-35 rat hepatoma cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B3121079X.

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31

Fairclough, Valerie Marie. "The role of ornithine decarboxylase in the transformation of skeletal muscle from fast-twitch to slow-twitch type." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333715.

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32

Zhao, Jianzhou. "¹H NMR study of ornithine and the development of Yb(EDDS), an aqueous chiral chemical shift reagent." Scholarly Commons, 1997. https://scholarlycommons.pacific.edu/uop_etds/2322.

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Ornithine is an amino acid of which the side chain contains three pairs of diastereotopic protons. The diastereotopic protons are chemically nonequivalent. The NOEDIF spectra of ornithine were obtained in an acid solution to assign the individual chemical shifts of the β diastereotopic protons with the aid of the theoretical calculation of conformation distribution. The β Pro-S resonance was found to be at a higher field than β pro-R proton. (S,S)-Ethylenediamine-N,N'-disuccinic acid (EDDS) was found to be a good chiral chemical shift reagent ligand in water solution. The Ytterbium complex of

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33

Smithson, David C. "Discovery of novel inhibitors of ornithine decarboxylase in Trypanosoma brucei: Development and application of a targeted high-throughput screening program." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390103.

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34

Searles, Lynne E. (Lynne Elizabeth). "Effects of orally administered spermidine on absorptive enzyme and nutrient transporter gene expression in the rat small intestine during postnatal development." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23298.

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The developmental profiles of mRNA and protein expression for ornithine decarboxylase (ODC), the Na$ sp+$-dependent glucose co-transporter (SGLT1), sucrase isomaltase (SI), and the Na$ rm sp+K sp+$ ATPase $ alpha sb1$ and $ beta sb1$ subunit isoforms in the postnatal rat small intestine, as well as the effects of exogenous spermidine on their precocious development, were examined. Postnatal age had a significant effect with all enzymes and the nutrient transporter maturing around weaning. Consecutive exposure to exogenous spermidine during suckling precociously induced ODC mRNA, SI protein, an

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35

Dhalluin, Stéphane. "Dysrégulations de l'ornithine décarboxylase et du processus d'apoptose dans les cellules embryonnaires de hamster syrien par des cancerogènes de l'environnement : relation avec la transformation phénotypique." Rouen, 1997. http://www.theses.fr/1997ROUE02NR.

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We have conducted a study to determine the carcinogenic potential of 2-methoxyethanol (ME), a member of the glycol ether family as compared to its reactive metabolite 2-methoxyacetaldehyde (MALD). Since disruption of equilibrium between cell prolifération and cell death is though to play a key role in multistage carcinogenesis, we investigated in Syrian hamster embryo (SHE) cells exposed to various doses of ME and MALD, early changes in apoptosis rate and in ornithine decarboxylase (ODC) metabolism. ODC is a key enzyme closely related to cell prolifération and cell transformation. As end-point

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36

Pyronnet, Stéphane. "Regulation de l'activite ornithine decarboxylase par la gastrine. Importance du controle de l'initiation de la traduction dans les cellules tumorales pancreatiques ar4-2j." Paris 7, 1997. http://www.theses.fr/1997PA077069.

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Les effats trophiques de la gastrine sont transmisapres occupation de son sous-type b de recepteur. Ce recepteur n'est pas detecte dans les cellules acineuses pancreatiques normales mais est fortement exprime dans les cellules tumorales ar4-2j. L'ornithine decarboxylase (odc), participant au phenotype tumoral, y est aussi surexprimee. Les travaux realises a l'aide de ce modele ont permi d'elucider d'une part, les mecanismes de l'activation constitutive de l'odc et, d'autre part, les voies de signalisation empruntees par la gastrine pour reguler l'enzyme. Un epissage alternatif de la region 5'

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37

Emmerson, Derek Alan. "Developmental patterns of tissue ornithine decarboxylase activity and nucleic acid concentrations in lines of turkeys differing in body weight and breast muscle development /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487694389394128.

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38

羅志良 and Che-leung Law. "Induction of ornithine decarboxylase activity in reuber H-35 hepatoma cells by systems A and N amino acids and the possible involvement ofthe Na+/H+ antiporter." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B31207315.

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39

Law, Che-leung. "Induction of ornithine decarboxylase activity in reuber H-35 hepatoma cells by systems A and N amino acids and the possible involvement of the Na+/H+ antiporter /." [Hong Kong : University of Hong Kong], 1986. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12323986.

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40

Goto, Yasuyuki, Kazuko Nishio, Yoshiko Ishida, et al. "No Association Between Helicobacter Pylori Seropositivity and Ornithine Decarboxylase (ODC) A317G Polymorphism, and No Modification by NAD(P)H : Qinone Oxidoreductase 1 (NQO1) C609T." Nagoya University School of Medicine, 2007. http://hdl.handle.net/2237/7474.

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41

Chintalapati, Chakravarthi [Verfasser], and Hermann [Akademischer Betreuer] Koepsell. "Ornithine decarboxylase is the receptor of regulatory protein RS1 (RSC1A1) mediating RS1 dependent shortterm regulation of glucose transporter SGLT1 / Chakravarthi Chintalapati. Betreuer: Hermann Koepsell." Würzburg : Universität Würzburg, 2013. http://d-nb.info/1111124620/34.

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42

Kutil, Brandi Lynn. "The evolution of LOL, the secondary metabolite gene cluster for insecticidal loline alkaloids in fungal endophytes of grasses." Thesis, [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1122.

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43

Busse, Leigh Anne. "Characterization of the interaction of putrescine and the adenosine-3' ,5'-cyclic monophosphate-cAMP receptor protein complex in the regulation of the speC gene encoding ornithine decarboxylase in Escherichia coli." Thesis, This resource online, 1988. http://scholar.lib.vt.edu/theses/available/etd-04122010-083645/.

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44

SCHMITT-HOFFMANN, ANNE. "Pharmacocinetique et metabolisme des enantiomeres de l'eflornithine (alpha-difluoromethyl-ornithine), un inhibiteur irreversible de l'ornithine decarboxylase et de la vigabatrine (acide gamma-vinyl-gamma-aminobutyrique), un inhibiteur irreversible de l'oxoglutarate aminotransferase." Université Louis Pasteur (Strasbourg) (1971-2008), 1990. http://www.theses.fr/1990STR13154.

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L'alpha-difluororomethylornithine (dfmo) ainsi que l'acide gamma-vinyl-gamma-aminobutyrique (gvg) sont deux inhibiteurs irreversibles d'enzymes. Le premier par inhibition irreversible de l'ornithine decarboxylase, permet une application therapeutique dans la trypanosomiase africaine. Le gvg inhibe la gaba-t et est commercialise sous le nom de sabril#r dans le traitement de l'epilepsie. Tous deux sont un melange racemique de deux enantiomeres, le distomere n'exercant que peu ou pas d'activite propre. La methode d'analyse des enantiomeres dans les fluides biologiques est une technique de chromat

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45

Williams, Marni. "Biochemical and structural characterization of novel drug targets regulating polyamine biosynthesis in the human malaria parasite, Plasmodium falciparum." Thesis, University of Pretoria, 2011. http://hdl.handle.net/2263/26237.

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Malaria is prevalent in over 100 countries which is populated by half of the world’s population and culminates in approximately one million deaths per annum, 85% of which occurs in sub-Saharan Africa. The combined resistance of the mosquitoes and parasites to the currently available pesticides and antimalarial chemotherapeutic agents requires the concerted effort of scientists in the malaria field to identify and develop novel mechanisms to curb this deadly disease. In this study, a thorough understanding of the role players in the polyamine pathway of the parasite was obtained, which could ai

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46

Wackenaer-Descleves, Estelle. "Les β-lactamases chromosomiques des Raoultella spp : support pour la résistance aux antibiotiques et outils de diagnostic étiologique". Paris 5, 2008. http://www.theses.fr/2008PA05T037.

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Les espèces de Raoultella (anciennement Klebsiella). R. Planticola (Rp), R. Ornithinolytica (Ro) et R. Terrigena (Rt) sont difficilement différentiables phénotypiquement des espèces de Klebsiella en routine. Après avoir (i) clone les p-Iactamases des Raoultella (PLA, ORN et TER), (ii) déterminé le niveau d'identité entre elles (94% entre PLA et ORN et 78 % avec TER) et avec les autres p-lactamases de la classe A (70% avec TEM-1, 68% avec SHV-1 et 38% avec KOXY) et (iii) démontré des différences notables entre les activités enzymatiques de PLA et de TER tant entre elles qu'avec TEM-1, la place

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47

丘國明 and Kwok-ming Yao. "Purification and characterization of ornithine decarbozylase fromtetrahymena thermophila." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B31207480.

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48

Yao, Kwok-ming. "Purification and characterization of ornithine decarbozylase fromtetrahymena thermophila /." Hong Kong : [University of Hong Kong], 1986. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12322829.

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49

López, Contreras Andrés Joaquín. "Caracterización de ODCp como una nueva proteína inhibidora de antizimias (AZIN2). Aspectos estructurales y funcionales." Doctoral thesis, Universidad de Murcia, 2008. http://hdl.handle.net/10803/10735.

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Las poliaminas regulan procesos de crecimiento y diferenciación celular, y su desregulación está relacionada con diferentes patologías incluyendo el cáncer. Las antizimas (AZs) de ornitina descarboxilasa (ODC) inhiben tanto su biosíntesis, como su captación, regulando los niveles intracelulares de poliaminas. En esta tesis se ha caracterizado una nueva proteína inhibidora de antizimas (AZIN2) que posee alta homología con ODC y el inhibidor de antizimas previamente conocido (AZIN1). Esta nueva proteína está desprovista de actividad enzimática, pero es capaz de revertir la acción que las tres an

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Costa, Fabiano de Vargas da. "ENVOLVIMENTO DAS POLIAMINAS NO ATAQUE AGUDO DE GOTA EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/9029.

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Abstract:

Fundação de Amparo a Pesquisa no Estado do Rio Grande do Sul<br>Gout attack is characterized severe joint pain and inflammation with concomitant accumulation of monosodium urate (MSU) crystals. However, gout and the mechanisms responsible for the acute attacks are poorly understood, leading to improper treatment of the patient and reducing the quality of life. Polyamines (putrescine, spermidine and spermine) are involved in inflammatory nociceptive processes and have not been investigated to date. Therefore, the aim of the present study was to investigate the involvement of polyamines in the d

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