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Journal articles on the topic 'Oromucosal'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Garnock-Jones, Karly P. "Oromucosal Midazolam." Pediatric Drugs 14, no. 4 (2012): 251–61. http://dx.doi.org/10.2165/11209320-000000000-00000.

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2

Szymańska, Emilia, Joanna Potaś, Marcin Baranowski, et al. "Evaluation of Oromucosal Natural Gum-Based Emulgels as Novel Strategy for Photodynamic Therapy of Oral Premalignant Lesions." Pharmaceutics 15, no. 10 (2023): 2512. http://dx.doi.org/10.3390/pharmaceutics15102512.

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Photodynamic therapy (PDT) recently has been shown as a promising option in the treatment of premalignant lesions of the soft oral tissues. Effective delivery of photosensitizer is challenging due to poor drug adherence to the oromucosal epithelium. In the present work, emulgels composed of natural polysaccharide gums (tragacanth, xanthan and gellan) were evaluated as novel oromucosal platforms of delta-aminolevulinic acid (ALA) for PDT. Apart from mucoadhesive and textural analysis, the specific steps involved studies on drug penetration behavior and safety profile using a three-dimensional h

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Xu, Dan, Chunmei Lan, Juan Kou, Shuxia Yao, Weihua Zhao, and Keith M. Kendrick. "Oromucosal Administration of Oxytocin: The Development of ‘Oxipops’." Pharmaceutics 16, no. 3 (2024): 333. http://dx.doi.org/10.3390/pharmaceutics16030333.

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The role of the hypothalamic neuropeptide oxytocin in influencing the brain and behavior has been the subject of widespread research over the last few decades due, most notably, to its reported involvement in promoting social cognition and motivation, reducing anxiety, and relieving pain. It is also increasingly being considered as an important therapeutic intervention in a variety of disorders with social dysfunction as a symptom. While, in recent years, studies in humans have administered oxytocin primarily via an intranasal route, since it may partly enter the brain directly this way via th

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4

Suragimath, Girish, Satish R. Patil, Manoj Patil, S. R. Ashwinirani, and Disha Suragimath. "Oromucosal Changes in Patients Receiving Radiotherapy for Head and Neck Cancers." Journal of Datta Meghe Institute of Medical Sciences University 19, no. 3 (2024): 555–61. http://dx.doi.org/10.4103/jdmimsu.jdmimsu_221_24.

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Abstract Background: Head-and-neck cancers (HNCs) rank as the seventh malignancies on a global scale. Radiotherapy is a modality for treating these cancers, causing unwanted harmful effects on the surrounding tissues. Aims and Objectives: The objective of this study was to evaluate the oromucosal changes during radiotherapy in HNC patients and correlate with radiation dosages. Materials and Methods: A total 90 HNC patients between 25 and 75 years of age, receiving radiotherapy were included. Two groups of patients were created depending on the radiation dosage, Group 1 (n = 62; 50–60 Gray [Gy]

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Dmytriieva, O. O., I. F. Bielenichev та B. S. Burlaka. "Optimisation of the composition of safe dental gel with IL-1β antagonist for the treatment of inflammatory periodontal diseases". Zaporozhye Medical Journal 26, № 2 (2024): 134–43. http://dx.doi.org/10.14739/2310-1210.2024.2.292521.

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Aim. The study aims to develop the composition of the oromucosal gel with the IL-1β interleukin antagonist for complex treatment of inflammatory periodontal diseases. Materials and methods. Experimental studies were conducted based on the Department of Medicines Technology of Zaporizhzhia State Medical and Pharmaceutical University and the Training Medical and Laboratory Center of Zaporizhzhia State Medical and Pharmaceutical University of the Ministry of Health of Ukraine. As an active component, in the recipe of oromucosal gel, used antagonist of the interleukin IL-1B. Excipients: D-pantheno

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Dubashynskaya, Natallia, Valentina Petrova, and Yury Skorik. "Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R & D." International Journal of Molecular Sciences 25, no. 10 (2024): 5359. http://dx.doi.org/10.3390/ijms25105359.

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Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral and parenteral dosage forms because it increases drug bioavailability and reduces systemic drug toxicity. The oral mucosa has a good blood supply, which ensures that drug molecules enter the systemic circulation directly, avoiding drug metabolism during the first passage through the liver. At the same time, the mucosa has a number of barriers, including mucus, epithelium, enzymes, and immunocompetent cells, that are designed to prevent the entry of foreign substances into the body, w

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7

Kumar, Sandeep, Prashant Mishra, Shilpa Warhekar, Bhuvnesh Airen, Deepika Jain, and Shaijal Godha. "Oral Health Status and Oromucosal Lesions in Patients Living with HIV/AIDS in India: A Comparative Study." AIDS Research and Treatment 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/480247.

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Oral health status of HIV positive individuals is in poor condition which may be a sequela of variety of factors. This study was aimed at assessing and comparing the oral health status and oromucosal lesions between HIV positive and negative individuals in India. A total of 126 HIV positive and 532 HIV negative individuals were recruited for the study. Oral health status and oromucosal lesions were recorded using WHO oral health assessment form (1997). Data was analyzed using chi-square and independent sample student’sttest. Majority (85.7%) of people suffering from HIV belonged to lower socio

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8

Beilharz, Manfred W., Martin J. Cummins, Alayne L. Bennett, and Joseph M. Cummins. "Oromucosal Administration of Interferon to Humans." Pharmaceuticals 3, no. 2 (2010): 323–44. http://dx.doi.org/10.3390/ph3020323.

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9

Eid, Pierre, Jean-Francois Meritet, Chantal Maury, Ahmed Lasfar, Dominique Weill, and Michael G. Tovey. "Oromucosal Interferon Therapy: Pharmacokinetics and Pharmacodynamics." Journal of Interferon & Cytokine Research 19, no. 2 (1999): 157–69. http://dx.doi.org/10.1089/107999099314306.

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10

Haddad, Fatma, Ghadeer Dokmak, and Rafik Karaman. "The Efficacy of Cannabis on Multiple Sclerosis-Related Symptoms." Life 12, no. 5 (2022): 682. http://dx.doi.org/10.3390/life12050682.

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Multiple sclerosis (MS) is known as an autoimmune disease that damages the neurons in the central nervous system. MS is characterized by its most common symptoms of spasticity, muscle spasms, neuropathic pain, tremors, bladder dysfunction, dysarthria, and some intellectual problems, including memory disturbances. Several clinical studies have been conducted to investigate the effects of cannabis on the relief of these symptoms in MS patients. The efficacy of Cannabis sativa (C. Sativa) in the management of MS outcomes such as spasticity, pain, tremors, ataxia, bladder functions, sleep, quality

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11

Szymańska, Emilia, Joanna Potaś, Mateusz Maciejczyk, et al. "Preliminary Assessment of Polysaccharide-Based Emulgels Containing Delta-Aminolevulinic Acid for Oral Lichen planus Treatment." Pharmaceuticals 16, no. 11 (2023): 1534. http://dx.doi.org/10.3390/ph16111534.

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Photodynamic therapy using delta-aminolevulinic acid is considered a promising option in the treatment of oral lichen planus. In the present work, three emulgel compositions prepared from natural polysaccharide gums, tragacanth, xanthan and gellan, were preliminarily tested for oromucosal delivery of delta-aminolevulinic acid. Apart from cytotoxicity studies in two gingival cell lines, the precise goal was to investigate whether the presence of the drug altered the rheological and mucoadhesive behavior of applied gelling agents and to examine how dilution with saliva fluid influenced the reten

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12

Pérez, J. "Combined cannabinoid therapy via an oromucosal spray." Drugs of Today 42, no. 8 (2006): 495. http://dx.doi.org/10.1358/dot.2006.42.8.1021517.

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Scully, C. "Cannabis; adverse effects from an oromucosal spray." British Dental Journal 203, no. 6 (2007): E12. http://dx.doi.org/10.1038/bdj.2007.749.

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14

Molska, G. Rigueira, C. Friedman, and D. Lam. "Novel preclinical model of postsurgical oromucosal pain." Journal of Pain 19, no. 3 (2018): S13. http://dx.doi.org/10.1016/j.jpain.2017.12.061.

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15

Mengesha, Mahilet, Anteneh Belete, and Tsige Gebre-Mariam. "Formulation and optimization of clotrimazole oromucosal emulgels." Ethiopian Pharmaceutical Journal 33, no. 2 (2018): 107. http://dx.doi.org/10.4314/epj.v33i2.4.

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Preis, Maren, Christina Woertz, Peter Kleinebudde, and Jörg Breitkreutz. "Oromucosal film preparations: classification and characterization methods." Expert Opinion on Drug Delivery 10, no. 9 (2013): 1303–17. http://dx.doi.org/10.1517/17425247.2013.804058.

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17

Swarnakar, Nitin K., Vikas Jain, Vaibhav Dubey, Dinesh Mishra, and N. K. Jain. "Enhanced Oromucosal Delivery of Progesterone Via Hexosomes." Pharmaceutical Research 24, no. 12 (2007): 2223–30. http://dx.doi.org/10.1007/s11095-007-9409-y.

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18

Flachenecker, Peter, Francesco Saccà, and Carlos Vila. "Variability of Multiple Sclerosis Spasticity Symptoms in Response to THC:CBD Oromucosal Spray: Tracking Cases through Clinical Scales and Video Recordings." Case Reports in Neurology 10, no. 2 (2018): 169–76. http://dx.doi.org/10.1159/000490376.

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Multiple sclerosis (MS) is an inflammatory and neurodegenerative autoimmune demyelinating disease of the central nervous system. Patients exhibit heterogeneous patterns of disabling symptoms, including spasticity. In the majority of patients with MS spasticity, it and its associated symptoms contribute to disability, interfere with performance of everyday activities, and impair quality of life. Even under treatment with oral antispasticity drugs, about a third of patients continue to experience spasticity of moderate to severe intensity, underscoring the need for additional treatment options.

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19

Maslii, Yuliia, Nataliia Herbina, Lina Dene, Liudas Ivanauskas, and Jurga Bernatoniene. "Development and Evaluation of Oromucosal Spray Formulation Containing Plant-Derived Compounds for the Treatment of Infectious and Inflammatory Diseases of the Oral Cavity." Polymers 16, no. 18 (2024): 2649. http://dx.doi.org/10.3390/polym16182649.

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According to data in the literature, natural products and essential oils are often used in dental practice. To develop a new oromucosal spray for the treatment of infectious and inflammatory diseases of the oral cavity, clove CO2 extract and essential oils of lavender and grapefruit were used as active pharmaceutical ingredients. Clove extract was obtained by the method of subcritical extraction from various raw materials, the choice of which was based on the yield of the CO2 extract and the study of its phytochemical and microbiological properties. Based on the results of microscopic and diff

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20

Dubashynskaya, Natallia V., and Yury A. Skorik. "Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives." International Journal of Molecular Sciences 23, no. 21 (2022): 12980. http://dx.doi.org/10.3390/ijms232112980.

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Mucoadhesive polymer patches are a promising alternative for prolonged and controlled delivery of topical corticosteroids (CS) to improve their biopharmaceutical properties (mainly increasing local bioavailability and reducing systemic toxicity). The main biopharmaceutical advantages of patches compared to traditional oral dosage forms are their excellent bioadhesive properties and their increased drug residence time, modified and unidirectional drug release, improved local bioavailability and safety profile, additional pain receptor protection, and patient friendliness. This review describes

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21

Wade, D. T., P. M. Makela, H. House, C. Bateman, and P. Robson. "Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis." Multiple Sclerosis Journal 12, no. 5 (2006): 639–45. http://dx.doi.org/10.1177/1352458505070618.

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The object of this study was to monitor the safety and efficacy of long-term use of an oromucosal cannabis-based medicine (CBM) in patients with multiple sclerosis (MS). A total of 137 MS patients with symptoms not controlled satisfactorily using standard drugs entered this open-label trial following a 10-week, placebo-controlled study. Patients were assessed every eight weeks using visual analogue scales and diary scores of main symptoms, and were followed for an average of 434 days (range: 21- 814). A total of 58 patients (42.3%) withdrew due to lack of efficacy (24); adverse events (17); wi

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22

Shende, Vaishali Waghmare, Shruti Kaushik, and Indu Nagpal. "Oromucosal lesions in women smokers: an Indian perspective." International Journal Of Community Medicine And Public Health 8, no. 5 (2021): 2619. http://dx.doi.org/10.18203/2394-6040.ijcmph20211800.

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Women smoking is looked down upon by Indian society. However, a young woman smoking is not a rare sight on college campuses in metro cities. Substantial body of literature indicates that nicotine is the major component which leads to addiction. The habit which starts to look cool and fashionable in no time becomes an addiction. Indian society, which doesn’t acknowledge that women are indulging in smoking, makes the whole fight about tobacco addiction a turbulent journey. As society doesn’t accept that women smoke, there is no need to create awareness about its gendered impact. The study was un

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23

Brown, Joanna L., and Anthony J. Frew. "The efficacy of oromucosal immunotherapy in respiratory allergy." Clinical & Experimental Allergy 31, no. 1 (2001): 8–10. http://dx.doi.org/10.1111/j.1365-2222.2001.01009.x.

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24

Tovey, Michael G., and Chantal Maury. "Oromucosal Interferon Therapy: Marked Antiviral and Antitumor Activity." Journal of Interferon & Cytokine Research 19, no. 2 (1999): 145–55. http://dx.doi.org/10.1089/107999099314298.

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25

Chaplin, Steve, and Ruth Dobson. "Sativex: oromucosal cannabinoid spray for spasticity in MS." Prescriber 21, no. 20 (2010): 34–37. http://dx.doi.org/10.1002/psb.684.

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26

Muhammad Talha, Syed, Pakeeza Zainab, Mamoona Khalid, and Areej Javed. "Enhancing Bioavailability with Oromucosal Products: Opportunities and Challenges." Fall 2023 VIII, no. IV (2023): 37–48. http://dx.doi.org/10.31703/gpsr.2023(viii-iv).04.

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The oral mucosa offers an attractive route for the systemic delivery of drugs. The bioavailability and effectiveness of many drugs can be increased by administering them through the oral mucosa which bypasses the first-pass metabolism effect. This article will discuss principles, application areas, benefits & drawbacks as well as possible future perspectives for the study and development of oromucosal drug delivery systems. Among the critical benefits of administering drugs via the mouth is that it starts acting fast, is easily absorbed into the bloodstream, makes it easier for patients to

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27

Dmytriieva, O. O., I. F. Bielenichev, I. B. Samura та V. I. Salnykov. "Some aspects of the therapeutic effect of dental gel with IL-1β antagonist in experimental chronic generalized periodontitis". Modern medical technology 17, № 2 (2025): 124–31. https://doi.org/10.14739/mmt.2025.2.322333.

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The aim of the current study was to evaluate the therapeutic efficacy of 1 % IL-1β antagonist dental gel by its effect on biomarkers of inflammation and cytoprotection under conditions of modelling chronic generalized periodontitis in rats. Materials and methods. Chronic generalized periodontitis (CGP) was reproduced in Wistar rats weighing 180–210 g by 8-week administration of the prooxidant Delagil (chloroquine phosphate, 30 mg/kg) and addition of EDTA (2 %) to drinking water using a calcium-deficient peroxide diet with reduced chewing function. The studied pharmacological medications were a

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28

Berillo, Dmitriy, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, and Arman Saparov. "Stimuli-Responsive Polymers for Transdermal, Transmucosal and Ocular Drug Delivery." Pharmaceutics 13, no. 12 (2021): 2050. http://dx.doi.org/10.3390/pharmaceutics13122050.

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Despite their conventional and widespread use, oral and intravenous routes of drug administration face several limitations. In particular, orally administered drugs undergo enzymatic degradation in the gastrointestinal tract and first-pass metabolism in the liver, which tend to decrease their bioavailability. Intravenous infusions of medications are invasive, painful and stressful for patients and carry the risk of infections, tissue damage and other adverse reactions. In order to account for these disadvantages, alternative routes of drug delivery, such as transdermal, nasal, oromucosal, ocul

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Liu, Ting, Xiang Gong, Yang Cai, Hao-Ying Li, and Ben Forbes. "Pullulan-Based Spray-Dried Mucoadhesive Microparticles for Sustained Oromucosal Drug Delivery." Pharmaceutics 16, no. 4 (2024): 460. http://dx.doi.org/10.3390/pharmaceutics16040460.

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Mucoadhesive microparticles for oromucosal drug delivery offer several advantages, including intimate contact with the mucosa, delivery to less accessible regions, extended residence time, sustained drug release, reduced irritation, and improved patient compliance. In this study, pullulan was used to prepare mucoadhesive spray-dried microparticles for delivering benzydamine hydrochloride (BZH) to oral mucosa. The BZH-pullulan spray-dried microparticles had a mean size of <25 μm with an angle of repose values between 25.8–36.6°. Pullulan markedly extended drug-release time to >180 min, ~9

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30

Mali, Bhushan, P. B. Patil, and R. S. Bachhav. "Medicated Chewing Gum- A Patient Friendly Oromucosal Drug Delivery." International Journal of Pharmaceutical Sciences and Medicine 6, no. 7 (2021): 128–52. http://dx.doi.org/10.47760/ijpsm.2021.v06i07.009.

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Over the years, simplification of patients and patient-centered research in the field of drug delivery has led to the emergence of new drug delivery options. In them, chewing gum (MCG) had the means to give the simplest medicine, not only to special groups with problems of swallowing like children and the elderly, but also to all people, including the younger generation. The chewing gum contains a thin layer of masticatory gum coating that can be a film of polymers, waxes, sugar, flavors, or colors. A chemical ingredient can be present in the core, in the coating, or in both. The level of orom

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31

Bastos, Francisca, Ana Catarina Pinto, António Nunes, and Sérgio Simões. "Oromucosal products – Market landscape and innovative technologies: A review." Journal of Controlled Release 348 (August 2022): 305–20. http://dx.doi.org/10.1016/j.jconrel.2022.05.053.

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32

Lindert, Sandra, and Jörg Breitkreutz. "Oromucosal multilayer films for tailor-made, controlled drug delivery." Expert Opinion on Drug Delivery 14, no. 11 (2017): 1265–79. http://dx.doi.org/10.1080/17425247.2017.1276899.

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33

Contin, Manuela, Luca Mancinelli, Alessandro Perrone, et al. "Tetrahydrocannabinol/Cannabidiol Oromucosal Spray in Patients With Multiple Sclerosis." Clinical Neuropharmacology 41, no. 5 (2018): 171–76. http://dx.doi.org/10.1097/wnf.0000000000000294.

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34

Lindert, S., M. Pein-Hackelbusch, and J. Breitkreutz. "Mucoadhesive oromucosal films of desmopressin acetate for paediatric use." International Journal of Pharmaceutics 511, no. 2 (2016): 1130–31. http://dx.doi.org/10.1016/j.ijpharm.2016.06.069.

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35

You, Jae Bem, Ah Young Choi, Jieung Baek, et al. "Application of Monodirectional Janus Patch to Oromucosal Delivery System." Advanced Healthcare Materials 4, no. 15 (2015): 2229–36. http://dx.doi.org/10.1002/adhm.201500416.

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36

Bastos, Francisca, Andreia Tabanez, Maria Aquino, António Nunes, and Sérgio Simões. "Oromucosal spray products – Viscosity impact on spray performance evaluation." Journal of Drug Delivery Science and Technology 94 (April 2024): 105480. http://dx.doi.org/10.1016/j.jddst.2024.105480.

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37

Wadetwar, Rita N., and Tejaswini Charde. "DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF OROMUCOSAL WAFER OF TRAMADOL HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 116. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.25709.

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Objective: The objective of the present work was the preparation of fast-dissolving film of tramadol HCl (TMH) using water-soluble polymer, to achieve faster onset of action, to improve patient compliance, ease of dosing, and bypass the first-pass metabolism. Methods: TMH oromucosal wafers were prepared using pullulan as natural, biodegradable polymer, and propylene glycol as plasticizer by solvent casting method. Formulation batches were prepared using 32 full-factorial designs. The prepared TMH oromucosal wafers were characterized for morphology, uniformity of weight, drug content, folding e

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38

Conte, Antonella, and Carlos Vila Silván. "Review of Available Data for the Efficacy and Effectiveness of Nabiximols Oromucosal Spray (Sativex®) in Multiple Sclerosis Patients with Moderate to Severe Spasticity." Neurodegenerative Diseases 21, no. 3-4 (2021): 55–62. http://dx.doi.org/10.1159/000520560.

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<b><i>Background:</i></b> Sativex (USAN: nabiximols [NAB]) oromucosal spray is indicated for treatment of multiple sclerosis (MS) patients with moderate to severe spasticity and inadequate response to other antispasticity medications who demonstrate clinically significant improvement during an initial trial of therapy. This narrative review investigated the efficacy and effectiveness of NAB oromucosal spray for moderate to severe MS spasticity by examining spasticity 0–10 numerical rating scale (NRS) data from interventional and observational studies which featured a 4-

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39

Patti, Francesco. "Newest evidence for tetrahydrocannabinol:cannabidiol oromucosal spray from postapproval pragmatic studies." Neurodegenerative Disease Management 9, no. 2s (2019): 3–7. http://dx.doi.org/10.2217/nmt-2018-0049.

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Marková, Jolana. "Newest evidence for tetrahydrocannabinol:cannabidiol oromucosal spray from randomized clinical trials." Neurodegenerative Disease Management 9, no. 2s (2019): 9–13. http://dx.doi.org/10.2217/nmt-2018-0050.

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41

Tittensor, Phil, Sarah Tittensor, Erica Chisanga, Manny Bagary, Caryn Jory, and Rohit Shankar. "UK framework for basic epilepsy training and oromucosal midazolam administration." Epilepsy & Behavior 122 (September 2021): 108180. http://dx.doi.org/10.1016/j.yebeh.2021.108180.

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Tian, Yu, Mine Orlu, Herman J. Woerdenbag, et al. "Oromucosal films: from patient centricity to production by printing techniques." Expert Opinion on Drug Delivery 16, no. 9 (2019): 981–93. http://dx.doi.org/10.1080/17425247.2019.1652595.

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43

Schellekens, Huub, Gerard Geelen, Jean-François Meritet, Chantal Maury, and Michael G. Tovey. "Oromucosal Interferon Therapy: Relationship Between Antiviral Activity and Viral Load." Journal of Interferon & Cytokine Research 21, no. 8 (2001): 575–81. http://dx.doi.org/10.1089/10799900152547830.

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44

Sander, Camilla, Katrine Dragsbæk Madsen, Birgitte Hyrup, Hanne Mørck Nielsen, Jukka Rantanen, and Jette Jacobsen. "Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration." European Journal of Pharmaceutics and Biopharmaceutics 85, no. 3 (2013): 682–88. http://dx.doi.org/10.1016/j.ejpb.2013.05.017.

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45

Mauro, Marcella, Matteo Crosera, Carlotta Bianco, et al. "In vitro permeability of silver nanoparticles through porcine oromucosal membrane." Colloids and Surfaces B: Biointerfaces 132 (August 2015): 10–16. http://dx.doi.org/10.1016/j.colsurfb.2015.04.061.

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46

Krchňák, Daniel, Ľudmila Balážová, Michal Hanko, Dominika Žigrayová, and Miroslava Špaglová. "In Situ Gelling Dexamethasone Oromucosal Formulation: Physical Characteristics Influencing Drug Delivery." Gels 11, no. 1 (2025): 26. https://doi.org/10.3390/gels11010026.

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The study focuses on the development of an in situ gelling dexamethasone (DEX) oromucosal formulation designed for the treatment of aphthous stomatitis. Three series of formulations were prepared; a first series containing DEX suspended, a second series containing DEX and, in addition, mint essential oil (EO), and a third series containing EO and DEX solubilized in propylene glycol (PG). In the composition, polymers in the role of mucoadhesive agent were interchanged (hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), methyl cellulose (MC), carbo

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El-Salamouni, Noha S., and Amira Sayed Hanafy. "Hyaluronic-benzydamine oromucosal films outperform conventional mouth rinse in ulcer healing." Journal of Drug Delivery Science and Technology 65 (October 2021): 102690. http://dx.doi.org/10.1016/j.jddst.2021.102690.

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48

KAUKINEN, H., J. ASPEGRÉN, S. HYYPPÄ, L. TAMM, and J. S. SALONEN. "Bioavailability of detomidine administered sublingually to horses as an oromucosal gel." Journal of Veterinary Pharmacology and Therapeutics 34, no. 1 (2011): 76–81. http://dx.doi.org/10.1111/j.1365-2885.2010.01193.x.

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49

Patti, F., S. Messina, C. Solaro, et al. "Efficacy and safety of cannabinoid oromucosal spray for multiple sclerosis spasticity." Journal of Neurology, Neurosurgery & Psychiatry 87, no. 9 (2016): 944–51. http://dx.doi.org/10.1136/jnnp-2015-312591.

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Jiang, Wang-Zhan, Yang Cai, and Hao-Ying Li. "Chitosan-based spray-dried mucoadhesive microspheres for sustained oromucosal drug delivery." Powder Technology 312 (May 2017): 124–32. http://dx.doi.org/10.1016/j.powtec.2017.02.021.

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