Relevant bibliographies by topics / Oropharyngeal squamous cell carcinoma

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Academic literature on the topic 'Oropharyngeal squamous cell carcinoma'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Oropharyngeal squamous cell carcinoma"

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Marur, Shanthi, and Barbara Burtness. "Oropharyngeal squamous cell carcinoma treatment." Current Opinion in Oncology 26, no. 3 (May 2014): 252–58. http://dx.doi.org/10.1097/cco.0000000000000072.

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McHugh, Jonathan B. "Association of Cystic Neck Metastases and Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma." Archives of Pathology & Laboratory Medicine 133, no. 11 (November 1, 2009): 1798–803. http://dx.doi.org/10.5858/133.11.1798.

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Abstract Human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. Similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. Human papillomavirus–associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. The histopathology of this subset of head and neck squamous cell carcinoma is unique and typically characterized by poorly differentiated, nonkeratinizing morphology with a basaloid appearance. These tumors occur in younger patients and are more often seen in nonsmokers compared with conventional oral cavity and oropharyngeal squamous cell carcinomas. The incidence of human papillomavirus–associated squamous cell carcinoma is increasing. Recognition of this unique clinicopathologic subset of head and neck carcinoma is important because these patients typically respond more favorably to organ-sparing treatment modalities and have an improved prognosis.
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Lehn, Carlos Neutzling, Ivo Marquis Beserra, Paulo Carvalho, Adriana Silva, Marcos Carvalho, and Viviane Santos. "FAS and FASL Polymorphisms in Oral / Oropharyngeal Cancer." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (August 2008): P37. http://dx.doi.org/10.1016/j.otohns.2008.05.122.

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Objective Examine the hypothesis if genetic polymorphisms in FAS and FASL genes, alone or in combination, are associated with oral and oropharyngeal squamous-cell carcinoma. Methods Prospective study based on 225 pacients with oral and oropharyngeal squamous-cell carcinoma and 215 controls, analyzed with PCR-RFLP. Results We observed a statistically significantly increased risk of oral and oropharyngeal squamous-cell carcinoma associated with the FASL -844 CT genotype (p=0,031). An increased risk of oral and oropharyngeal squamous-cell carcinoma was also associated with the FASL −844 T allele (p=0,04). Gene-gene interactions of FAS and FASL polymorphisms increased the risk of oral and oropharyngeal squamous-cell carcinoma in a multiplicative manner (p=0,04). Conclusions The results suggest that the presence of the allele T of FASL and its combination with G allele potentially increase the risk of cancer development.
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Smith, Timothy J., Anthony Mendez, Carrlene Donald, and Thomas Harold Nagel. "HPV-associated oropharyngeal squamous cell carcinoma." Journal of the American Academy of Physician Assistants 30, no. 1 (January 2017): 14–19. http://dx.doi.org/10.1097/01.jaa.0000510985.76167.ed.

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Polatova, D. Sh, and A. Yu Madaminov. "Molecular and clinical aspects of oropharyngeal squamous cell carcinoma associated with human papillomavirus." Head and Neck Tumors (HNT) 11, no. 2 (August 8, 2021): 31–40. http://dx.doi.org/10.17650/2313-805x-2021-11-2-31-40.

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Currently, the role of human papillomavirus (HPV) in carcinogenesis is well known: more than 90 % of HPV-positive oropharyngeal squamous cell carcinomas are caused by HPV type 16 (HPV-16). HPV E6 and E7 oncoproteins play a significant role in the development of this tumor. The E6- mediated degradation of suppressor protein p53 results in G2/M-phase checkpoint dysregulation and inhibition of apoptosis. HPV oncoprotein E7 binds to pRb, promoting its degradation and the release of E2F transcription factor. Diagnostic assays for HPV detection include immunohistochemical staining for p16, polymerase chain reaction, in situ hybridization, and next-generation sequencing. Immunohistochemical examination (determination of p16 protein expression) is an economical and very specific way to detect a viral infection. Patients with HPV-positive oropharyngeal squamous cell carcinoma demonstrate significantly better response to treatment and overall survival rates than those with HPV-negative oropharyngeal squamous cell carcinoma. Despite the fact that five-year overall survival rate in patients with HPV-positive oropharyngeal squamous cell carcinoma after treatment exceeds 80 %, some patients have poor survival. Unfortunately, currently available methods of risk stratification still do not endure their timely identification. Further research is needed to address these problems.
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Mohamed, Hesham, Jaana Hagström, Lauri Jouhi, Timo Atula, Alhadi Almangush, Antti Mäkitie, and Caj Haglund. "The expression and prognostic value of stem cell markers Bmi-1, HESC5:3, and HES77 in human papillomavirus–positive and –negative oropharyngeal squamous cell carcinoma." Tumor Biology 41, no. 3 (March 2019): 101042831984047. http://dx.doi.org/10.1177/1010428319840473.

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Human papillomavirus is detected in over 50% of oropharyngeal squamous cell carcinomas. Human papillomavirus–positive oropharyngeal squamous cell carcinomas differ from human papillomavirus–negative tumors, and both expression patterns are classified as distinct entities. The Bmi-1 oncogene is a well-known member of the mammalian polycomb-group family. HESC5:3 and HES77 are newly developed monoclonal antibodies produced against undifferentiated embryonic stem cells. Our aim was to explore their roles in both human papillomavirus–positive and –negative oropharyngeal squamous cell carcinomas. Our cohort comprised 202 consecutive oropharyngeal squamous cell carcinoma patients diagnosed and treated with curative intent. We used tissue microarray tumor blocks to study the immunohistochemical expression of Bmi-1, HESC5:3, and HES77. We compared the expressions of these stem cell markers with p16 immunoexpression and human papillomavirus status, as well as with other characteristics of the tumor, and with patients’ clinical data and follow-up data. Human papillomavirus– and p16-positive tumors expressed less Bmi-1 and more HESC5:3 than the negative tumors. HES77 expression was high in human papillomavirus–positive oropharyngeal squamous cell carcinoma, but it did not correlate with p16 positivity. In our multivariable model, Bmi-1 and HESC5:3 were still associated with human papillomavirus, but the association between human papillomavirus and HES77 remained absent. In conclusion, Bmi-1, HESC5:3, and HES77 may have a different role in human papillomavirus–positive and human papillomavirus–negative tumors. There was no correlation between Bmi-1, HESC5:3, and HES77 expression and survival.
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Milovanovic, Jovica, Ana Jotic, Dragoslava Andrejic, Aleksandar Trivic, Bojan Pavlovic, Katarina Savic-Vujovic, Ana Banko, Andjela Milovanovic, and Vojko Djukic. "Prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in Serbia." Srpski arhiv za celokupno lekarstvo 146, no. 5-6 (2018): 271–78. http://dx.doi.org/10.2298/sarh1806271m.

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Introduction/Objective. Oropharyngeal carcinoma makes up to 3% of all newly diagnosed carcinomas in the world. In Serbia, oropharyngeal carcinoma constitutes 1.8% of all malignancies. Studies have shown a growing role of infections with human papilloma viruses (HPV) in oropharyngeal cancer etiology. HPV positive patients have a more favorable prognosis and significantly higher rate of overall survival. The purpose of this paper was to establish how HPV status influenced Serbian patients? overall survival and the disease-free survival according to known risk factors (tobacco and alcohol consummation), clinical TNM stage of the disease, and modality of treatment. Methods. The study included 87 patients treated for oropharyngeal carcinoma in a one-year period with a five-year follow-up. Treatment modalities included surgery with or without postoperative radio- or chemoradiotherapy, only radiotherapy or chemoradiotherapy. Sex, common risk factors, TNM stage, and treatment method were considered, as well as the influence of HPV status on the overall survival and the disease-specific survival depending on the presence of risk factors. Results. HPV-positive patients with oropharyngeal carcinoma were more frequently men, smokers, and alcohol consumers. Considering clinical T, N, and M stage of the disease, the overall survival and the disease-specific survival rates were better in HPV-positive patients, who had better survival if they were treated with primary surgical therapy rather than primary radiotherapy. Conclusion. HPV status significantly influenced survival and locoregional control in Serbian patients with oropharyngeal carcinoma. This implies possible modifications of treatment strategies for these patients in order to further improve their prognosis and treatment outcomes.
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Kao, S. S., and E. H. Ooi. "Survival outcomes following salvage surgery for oropharyngeal squamous cell carcinoma: systematic review." Journal of Laryngology & Otology 132, no. 4 (May 15, 2017): 299–313. http://dx.doi.org/10.1017/s0022215117000998.

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AbstractBackground:Recurrent oropharyngeal squamous cell carcinoma causes great morbidity and mortality. This systematic review analyses survival outcomes following salvage surgery for recurrent oropharyngeal squamous cell carcinoma.Methods:A comprehensive search of various electronic databases was conducted. Studies included patients with recurrent or residual oropharyngeal squamous cell carcinoma treated with salvage surgery. Primary outcomes were survival rates following salvage surgery. Secondary outcomes included time to recurrence, staging at time of recurrence, post-operative complications, and factors associated with mortality and recurrence. Methodological appraisal and data extraction were conducted as per Joanna Briggs Institute methodology.Results:Eighteen articles were included. The two- and five-year survival rates of the patients were 52 per cent and 30 per cent respectively.Conclusion:Improvements in treatment modalities for recurrent oropharyngeal squamous cell carcinoma were associated with improvements in two-year overall survival rates, with minimal change to five-year overall survival rates. Various factors were identified as being associated with long-term overall survival, thus assisting clinicians in patient counselling and selection for salvage surgery.
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Lewis, James S., Beth Beadle, Justin A. Bishop, Rebecca D. Chernock, Carol Colasacco, Christina Lacchetti, Joel Todd Moncur, et al. "Human Papillomavirus Testing in Head and Neck Carcinomas: Guideline From the College of American Pathologists." Archives of Pathology & Laboratory Medicine 142, no. 5 (December 18, 2017): 559–97. http://dx.doi.org/10.5858/arpa.2017-0286-cp.

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Context Human papillomavirus (HPV) is a major cause of oropharyngeal squamous cell carcinomas, and HPV (and/or surrogate marker p16) status has emerged as a prognostic marker that significantly impacts clinical management. There is no current consensus on when to test oropharyngeal squamous cell carcinomas for HPV/p16 or on which tests to choose. Objective To develop evidence-based recommendations for the testing, application, interpretation, and reporting of HPV and surrogate marker tests in head and neck carcinomas. Design The College of American Pathologists convened a panel of experts in head and neck and molecular pathology, as well as surgical, medical, and radiation oncology, to develop recommendations. A systematic review of the literature was conducted to address 6 key questions. Final recommendations were derived from strength of evidence, open comment period feedback, and expert panel consensus. Results The major recommendations include (1) testing newly diagnosed oropharyngeal squamous cell carcinoma patients for high-risk HPV, either from the primary tumor or from cervical nodal metastases, using p16 immunohistochemistry with a 70% nuclear and cytoplasmic staining cutoff, and (2) not routinely testing nonsquamous oropharyngeal carcinomas or nonoropharyngeal carcinomas for HPV. Pathologists are to report tumors as HPV positive or p16 positive. Guidelines are provided for testing cytologic samples and handling of locoregional and distant recurrence specimens. Conclusions Based on the systematic review and on expert panel consensus, high-risk HPV testing is recommended for all new oropharyngeal squamous cell carcinoma patients, but not routinely recommended for other head and neck carcinomas.
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Dong, Jianfeng, Lijun Cheng, Minchao Zhao, Xiangfeng Pan, Zhiqiang Feng, and Dawei Wang. "Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression." Tumor Biology 39, no. 5 (May 2017): 101042831770165. http://dx.doi.org/10.1177/1010428317701651.

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Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development. Strong antitumor immune responses, especially CD8+ T cell responses, are thought to be essential to effective cancer treatment and are associated with better prognosis in oropharyngeal head and neck squamous cell carcinoma. In this study, we examined the role of the Tim-3/Gal-9 pathway in oropharyngeal head and neck squamous cell carcinoma patients. We found that Gal-9 expression by CD4+ T cells was increased in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients, but not in human papillomavirus-negative oropharyngeal head and neck squamous cell carcinoma patients. Increased Gal-9 secretion by CD4+ T cells presented multiple immunosuppressive effects. Coculturing monocytes with high Gal-9-expressing CD4+ T cells resulted in the expansion of Tim-3+ monocytes, which suppressed interferon gamma production by activated CD8+ T cells. Subsequently, total monocytes incubated with exogenous Gal-9, or high Gal-9-expressing CD4+ T cells, suppressed the expression of interferon gamma by CD8+ T cells. Exogenous Gal-9 and high Gal-9-expressing CD4+ T cells also suppressed the secretion of both interleukin 10 and interleukin 12 by monocytes. These effects are Tim-3/Gal-9-dependent because blocking Tim-3 and/or Gal-9 could enhance the support of CD8+ T cell interferon gamma production and the interleukin 10 and interleukin 12 secretion by monocytes. Together, these data suggest that the high Tim-3 expression in monocytes could be utilized by tumor-promoting Gal-9 expression on CD4+ T cells. Immunotherapy in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients therefore faces an additional challenge posed by Tim-3 and Gal-9 and likely requires the blockade of these molecules.
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Dissertations / Theses on the topic "Oropharyngeal squamous cell carcinoma"

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Schache, Andrew G. "The molecular and clinical implications of human papillomavirus-16 mediated oropharyngeal squamous cell carcinoma." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/13433/.

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The last three decades have seen a fundamental change in the profile of oropharyngeal squamous cell carcinoma (OPSCC) within the developed world. The incidence of OPSCC attributable to tobacco and alcohol exposure has been gradually declining whilst Human papillomavirus (HPV)-related OPSCC has seen a rapid increase. Detection of High Risk HPV has profound prognostic significance as it correlates with both a disease-specific and an overall survival advantage. The stringency of testing, both in terms of diagnostic and prognostic capacity is therefore of increasing importance. This study sought to define the relative abilities of the diagnostic tests presently available in clinical practice and to explore the potential of a novel test in reaching the improved stringency called for by the clinical community. Diagnostic biomarkers with prognostic capacity, such as those utilised in defining HPV status in this research have been well described, however, despite HPV positive OPSCC being biologically distinct from HPV negative malignancy, predictive biomarkers defining the transition from persistent to transforming infection are yet to be forthcoming. A lack of an apparent premalignant state, akin to that seen in HPV-mediated cervical malignancy has restricted biomarker recognition. This research aimed to better define the epigenetic state and clarify the impact of viral integration for the virus and host in HPV positive OPSCC. Although detectable epigenetic alterations, within the genome of the virus and that of the host, were capable of providing an improved description of this burgeoning disease state, they fell short of providing clinically relevant biomarkers. It was however demonstrated that the previously held concept of preferential E2 cleavage during viral integration as a means to disrupt gene expression, is overstated and the model persists to the exclusion of other viral and host genome disruptions. A paradigm shift may be necessary in HPV positive OPSCC to an understanding of obligatory viral integration, the significance of which however, is yet to be fully elucidated.
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Anand, Sumeet M. 1978. "The correlation between tumour volume and survival in oral cavity and oropharyngeal squamous cell carcinoma /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111587.

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The Tumour-Node-Metastasis (TNM) classification system of tumour stage does not always reflect the actual tumour mass present at diagnosis. Recent reports propose that volumetric analysis may allow improved stratification of disease recurrence and survival in head and neck squamous cell cancer (SCC). This study aims to assess the prognostic value of tumour volume on the outcome of patients with oral cavity and oropharyngeal SCC.
A retrospective review of 73 patients was completed. Tumours were outlined semi-automatically in digitized computed tomography scans, and volumes computed based on surface triangulations of three-dimensional reconstructions with novel software developed at McGill.
Results illustrate significant interstage variability within the current TNM model. Moreover, in oral cavity and oropharyngeal SCC, tumour volume as well as T-stage are significant and independent predictors of disease free survival and overall survival.
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Moran, Michael. "HPV-related oropharyngeal squamous cell carcinoma in Northern Ireland : a molecular and population based study." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678211.

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Oropharyngeal cancers are increasing in incidence worldwide, and many of these tumours are caused by the human papillomavirus. This is a DNA virus that integrates into the host's genetic information, and can cause cancer through suppression of important tumour suppressors such as p53. TP53 is a gene that codes for p53, and in many cancers of the head and neck this is thought to be mutated. In NI, limited emigration provides an excellent context for research that depends on long-term follow up of patients. This study assesses molecular and demographic characteristics of patients and their tumours, in order to build a comprehensive of the emerging disease of oropharyngeal cancer. Methods Retrospective review of head and neck pathology reports was conducted for a twelve-year period, and all primary oropharyngeal squamous cell carcinomas were included. Detailed clinical and pathological information was gathered about patients and their tumours, and tissue microarrays were created for analysis of protein markers. In addition, DNA and RNA were extracted from a cohort of tumours, to study the tumour suppressor p53, and its family member p63. Different HPV testing methods were compared with one another, in order to ascertain the most reliable test for diagnosing presence of active virus in the oropharynx. Outcomes It was determined that testing for HPV is necessary in tumours arising in the oropharynx, and the best testing method for this appears to be detection of HPV DNA using chromatin in situ hybridisation. p53 mutations were found at a rate comparable with other studies in the head and neck, however the mutation profile appeared to be slightly different to that of other anatomical subsites. Studies of TP63 gene expression revealed that high levels of delta-Np63 are associated with disease recurrence and decreased survival, suggesting a role for this in tumour invasion and metastasis.
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Chiriseri, Edina. "Human papilloma virus and oral cancers : sexual behaviour as a risk factor." Thesis, De Montfort University, 2017. http://hdl.handle.net/2086/16084.

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AIM & OBJECTIVES: Human papilloma virus (HPV) has been related to cervical infection, however, its part in Head and Neck Squamous Cell Carcinoma (HNSCC) is still debatable and is easy to refute. Suspicion of HPV causation is heightened when carcinomas arise in patients that are young and have never smoked. The present UK based study undertaken at Northampton NHS Trust endeavoured to determine the extent to which HPV is an entity in HNSCC in the UK. Furthermore, the study investigated whether sexual behaviour (as measured by sexual health clinic (SHC) attendance) is linked the acquisition of HPV associated HNSCC in young age groups. HNSCC incidences and sexual trends in the UK were collected from publicly available databases to identify if there were any changes at a national level in sexual behaviours and their influence on HNSCC in young age groups. MATERIALS & METHODS: PCR was used to evaluate the presence of HPV in biopsy samples from of 99 patients diagnosed with HNSCC at Northampton Hospital from 2006 to 2014. Patient demographics on age, sex, smoking, alcohol use and SHC attendance were also collected. All HPV PCR positive biopsies were further genotyped using an ABI 3130xl genetic analyser. Databases in the UK; including GLOBOCAN, NATSAL and PHE were searched for data on HNSCC prevalence, sexual behaviour trends and vaccine uptake. Multinomial regression explored the relationship between HPV positivity and sex, age, smoking, drinking, race and SHC attendance. RESULTS: PCR showed that 25.2% (25/99) of biopsies tested were positive for HPV and were all obtained from white participants. Most specimens (23, 92%) were high-risk (HR) HPV 16 positive with a mean age of 56 for HPV positivity and 72% of the cases 50-60 years old. Smokers were 11% in total (11/99) with most 88.9% participants (88/99) being non-smokers. HPV positivity was strongly linked with non-smoking history (p < 0.001); no alcohol abuse (p < 0.001); male gender (p < 0.001); young age less than 60 years (p < 0.001) and SHC attendance (p < 0.001). A Kruskal-Wallis post hoc test affirmed the impact of age on HPV positivity (p= < 0.05). GLOBOCAN and Cancer Research demonstrated a rising UK HNSCC pattern of over 200% for both sexes from 1975 to 2011. The three NATSAL surveys undertaken in 1990-1991, 1999-2001 and 2010-2012 demonstrated an overall increase in opposite and same sex partners. The UK average of individuals engaging in oral sex was in the younger age groups of between 16 and 54 with at least 70% of males and 63% females of that age engaging in oral sex. Finally, NASTAL 1, 2 and 3 surveys reported 20 vs 15; 25 vs 55; 55 vs 65 of males and females respectively with more than 10 sexual partners to have attended the SHC. The UK immunization take-up was over 90% countrywide. CONCLUSION: Few research studies have been conducted to date on HPV as a cause of HNSCC in the UK. The present research showed 25.2% of HNSCC to be caused by HPV, with the high risk (HR) genotype 16 (the leading cause of cervical cancer) accounting for 92% (23/25) of the cases. These outcomes affirmed the high prevalence of HR-HPV in HNSCC, with a rate of 25.2% similar to those reported previously. Routine HPV testing in those aged below 60 is therefore warranted. Smoking and drinking showed negative correlation; the young age of below 60 and attendance of the SHC for both sexes showed a positive correlation with HPV positive HNSCC. NATSAL data showed increased sexually risky behaviour coupled with attending the SHC in younger ages for both sexes. Increased sexually risky behaviour as shown in NASTAL surveys may be the reason why young age and SHC attendance is positively correlated with HPV HNSCC. The study highlights a conceivable relationship between HPV positive HNSCC in those under 60 years with no smoking history who attended the SHC. Smoking and drinking are known risks for HNSCC in those past 65 years of age; the negative association with HPV HNSCC in the young in the present research revealed smoking and drinking to have reduced association with HPV HNSCC. The reported HR-HPV positive HNSCC in young age groups inform future vaccination strategies and consequently decrease the quantity of HPV HNSCC's.
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Velinov, Nikolay. "Matrix metalloproteinase-19 is a predictive marker for tumour invasiveness in patients with oropharyngeal squamous-cell carcinoma /." Bern : [s.n.], 2007. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Qian, Xu [Verfasser]. "ALDH1-positive cancer stem-like cells enrich in nodal metastases of oropharyngeal squamous cell carcinoma independently of HPV-status / Xu Qian." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1043197427/34.

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Schroeder, Lea [Verfasser], and Michael [Akademischer Betreuer] Pawlita. "Human papillomavirus-driven neck lymph node metastases from oropharyngeal or unknown primary squamous cell carcinoma / Lea Schroeder ; Betreuer: Michael Pawlita." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1180986466/34.

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Smith, Eric A. B. S. "DEK is a Homologous Recombination DNA Repair Protein and Prognostic Marker for a Subset of Oropharyngeal Carcinomas." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480040523791.

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Dapaah, Gloria Fremah. "The prevalence of HPV-positive Oropharyngeal squamous cell carcinoma at one of the largest tertiary care centers in Sub-Saharan Africa Tygerberg Hospital." University of the Western Cape, 2004. http://hdl.handle.net/11394/8145.

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Magister Chirurgiae Dentium (MChD)
CONTEXT Limited data on the prevalence of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) in Sub-Saharan Africa exist. The aim of the current study was to determine the prevalence of HPV-positive OPSCC at one of the largest tertiary care centers in the region (Tygerberg Hospital, Cape Town, South Africa). METHODS Sequential surgical samples of 266 cases of OPSCC diagnosed over a 10-year period (2007-2017) were selected for evaluation and relevant patient characteristics were documented. p16 immunohistochemistry (IHC) was performed as a screening test. All p16 positive cases were further evaluated for HR-HPV using BD onclarity™ HPV assay (BD Diagnostics, Sparks, USA), a real-time PCR assay that detects type-specific E6 and E7 genomic DNA. RESULTS Of 266 OPSCC cases, 14% (n=36) were positive for p16. Of those p16-positive cases, 23 were negative and 13 (13/266=5%) were positive for HR-HPV when evaluated by PCR. P16 was found to have a positive predictive value (PPV) of only 36.1%. HPV subtypes were HPV-16 (n=10), HPV-18 (n=1), HPV-52 (n=1) and HPV-31 (n=1). One case was positive for HPV-16 and HPV-31. HPV-positive OPSCC occurred in 10 men and 3 women (male: female ratio 3.3:1) with a mean age of 51 years (range: 33 to 72 years). All HPV-positive OPSCC arose from the tonsil (n=10) and base of tongue (n=3). Most HPV-positive OPSCC were non-keratinizing (n=10) or partially keratinizing (n=1). In contrast, HPV-negative OPSCC were predominantly keratinizing (n=218). A positive history of smoking was significantly correlated with a negative HPV status (p=0.08) CONCLUSIONS The presence of HR-HPV in 5% of OPSCC cases, in one of the largest tertiary care centers in Sub-Saharan Africa (Tygerberg Hospital), suggests HR-HPV as a minor etiologic agent in OPSCC in this region. Due to its sub-optimal positive predictive value (36.1%), p16 IHC is a less reliable marker for HR-HPV infection due to high incidence of tobacco and alcohol related diseases in this region. When positive, HPV-specific testing should be performed by one of the available platforms. The identification of the less common HR-HPV types; HPV-52 and HPV-31, in our cohort of HPV-positive OPSCC cases, may have implications for in-situ hybridization (ISH) HPV cocktails and current local vaccination strategies.
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Dugoni, Meredith L. "Role of the Pediatric Dental Provider in Human Papillomavirus (HPV) Education." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4733.

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Purpose: This study investigates knowledge about HPV and examines if pediatric dental providers should include HPV education for guardians of patients 10-18 years. Methods: Legal guardians of 10-18 year-old patients of the Virginia Commonwealth University Pediatric Dental Clinic were enrolled in this prospective cohort study. Participants completed a baseline survey, were provided HPV education, completed an initial follow-up survey, and then completed a 6-month follow-up survey. Results: A total of 54 participants completed the baseline and initial follow-up surveys and 17 completed the 6-month follow-up survey. The average number of correct responses was 3.4 of 6 knowledge questions, which significantly improved to 5.4 at follow-up (P<.0001). The greatest increase in the percent responding correctly was regarding HPV and oropharyngeal cancer from 22% baseline to 91% at initial follow-up (P<.0001). Regarding Stage of Change, 14 (23%) of those not initially in the Action group had improved at least 1 stage. At the 6-month follow-up, 3 (43%) guardians reported completing the HPV vaccine series. Conclusions: These results demonstrate limited knowledge about HPV and highlight the pediatric dental provider’s ability to educate. Since the greatest knowledge gap pertained to HPV and oropharyngeal cancer, it is important for pediatric dental providers to increase their role in HPV education. As oral cancers are the purview of dentists, practitioners should be involved with their patients’ consideration of the HPV vaccine.
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Books on the topic "Oropharyngeal squamous cell carcinoma"

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Mortensen, Daniel V. Squamous cell carcinoma. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Warnakulasuriya, Saman, and Zakir Khan, eds. Squamous cell Carcinoma. Dordrecht: Springer Netherlands, 2017. http://dx.doi.org/10.1007/978-94-024-1084-6.

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Ando, Nobutoshi, ed. Esophageal Squamous Cell Carcinoma. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-4190-2.

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Ando, Nobutoshi, ed. Esophageal Squamous Cell Carcinoma. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-54977-2.

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Lam, Alfred K., ed. Esophageal Squamous Cell Carcinoma. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0377-2.

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Schmults, Chrysalyne D., ed. High-Risk Cutaneous Squamous Cell Carcinoma. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47081-7.

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de Manzoni, Giovanni, ed. Treatment of Esophageal and Hypopharyngeal Squamous Cell Carcinoma. Milano: Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2330-7.

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Thankappan, Krishnakumar. Per Oral Resection of Oral Tongue Squamous Cell Carcinoma. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6065-1.

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Society, American Cancer. Basal and squamous cell skin cancer: What you need to know-- now. Atlanta, Ga: American Cancer Society/Health Promotions, 2012.

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Waes, Carter Van, and Adam B. Glick. Signaling pathways in squamous cancer. New York: Springer, 2011.

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Book chapters on the topic "Oropharyngeal squamous cell carcinoma"

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Wein, Richard, and Randal S. Weber. "Oropharyngeal Squamous Cell Carcinoma." In Evidence-Based Otolaryngology, 643–59. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-49979-6_29.

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Agbetoba, Abib A., and Brett A. Miles. "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma." In ENT Board Prep, 235–46. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8354-0_21.

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Gollin, Susanne M. "Epidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma." In Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer, 1–23. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21100-8_1.

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Miller, Daniel Lee, and M. Sharon Stack. "MicroRNA Profiles of HPV-Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC)." In Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer, 133–52. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21100-8_6.

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Gkolfinopoulos, Stavros, Panagiota Economopoulou, and Amanda Psyrri. "Prognostic Role of p16/HPV in Non-oropharyngeal Head and Neck Squamous Cell Cancer (HNSCC)." In Critical Issues in Head and Neck Oncology, 181–92. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_12.

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AbstractTranscriptionally active HPV infection is recognized as a prognostic factor in oropharyngeal squamous cell carcinoma. Also, p16 positivity has been established as an effective surrogate biomarker for HPV and shares its prognostic significance in cancer of the oropharynx. Less clear is the prognostic role of p16/HPV status in non-oropharyngeal head and neck cancers since relevant studies have produced conflicting results. The existing evidence suggests that p16 is a poor surrogate marker for HPV infection in non-oropharyngeal cancers, while the prognostic impact of HPV positivity is reserved for the oropharynx. Consequently, routine HPV testing is not recommended for disease sites of the head and neck outside oropharynx.
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Epstein, Joel B., and Dena J. Fischer. "Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: Clinical Considerations." In HPV and Cancer, 183–92. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-5437-9_8.

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Anderson, Teresa A., and Aaron C. Ermel. "Behavioral Correlates of HPV-Associated Oropharyngeal Squamous Cell Carcinomas." In Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer, 25–42. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21100-8_2.

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Kurago, Zoya B., Aroonwan Lam-ubol, and Catherine M. Flaitz. "Role of Microorganisms in Oral and Oropharyngeal Squamous Cell Carcinoma." In Encyclopedia of Metagenomics, 564–76. Boston, MA: Springer US, 2015. http://dx.doi.org/10.1007/978-1-4899-7475-4_61.

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Kurago, Zoya B., Aroonwan Lam-ubol, and Catherine M. Flaitz. "Role of Microorganisms in Oral and Oropharyngeal Squamous Cell Carcinoma." In Encyclopedia of Metagenomics, 1–14. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-6418-1_61-11.

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Rischin, Danny. "Biomarkers for Immune Modulatory Treatment in Head and Neck Squamous Cell Carcinoma (HNSCC)." In Critical Issues in Head and Neck Oncology, 83–91. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_6.

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AbstractImmune checkpoint inhibitors have changed the standard of care for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, only a minority of patients respond, hence the search for predictive biomarkers. Potential predictive biomarkers for immune checkpoint inhibitors discussed in this chapter include (1) Immune checkpoint ligand expression e.g., PD-L1, (2) biomarkers of a T-cell inflamed tumour microenvironment (TME) such as gene expression profiles of activated T cells, (3) biomarkers of tumour neoepitope burden such as tumour mutation burden (TMB) and (4) multidimensional quantitative techniques. At present only PD-L1 expression has been shown to have clinical utility in head and neck cancer. It enriches for populations more likely to respond, but the false positive predictive value remains high. In the pivotal Keynote−048 trial that established a role for pembrolizumab (anti-PD1) monotherapy and pembrolizumab + chemotherapy as treatment options in first-line R/M HNSCC, primary endpoints included overall survival in defined subgroups based on PD-L1 expression. In this trial the combined positive score (CPS) was used which takes into account PD-L1 expression in tumour and immune cells. Based on this trial regulatory approvals for first-line pembrolizumab in R/M HNSCC require assessment of PD-L1 expression using the CPS. Finally we discuss emerging evidence that locoregionally advanced HPV-associated oropharyngeal cancers that have high expression of CD103 positive CD8 T cells have an excellent prognosis and features that suggest increased probability of responding to anti-PD1/PD-L1, raising the possibility of incorporating these immune therapies as part of a de-escalation trial strategy.
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Conference papers on the topic "Oropharyngeal squamous cell carcinoma"

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Lees, Katherine, Jamie Van Gompel, and Jeffrey Janus. "Metastatic Oropharyngeal Squamous Cell Carcinoma to the Cavernous Sinus." In 29th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1679681.

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Würdemann, N., K. Pütz, S. Wagner, HFS Reder, S. Gattenlöhner, SJ Sharma, C. Wittekindt, A. Quaas, and JP Klußmann. "HPV-driven immune modulation in oropharyngeal squamous cell carcinoma." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686099.

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Baumeister, P., M. Canis, and M. Reiter. "Preoperative risk stratification of patients with oropharyngeal squamous cell carcinoma." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1639976.

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Oprea-Ilies, Gabriela M., Charles Moore, Mylar Joseph Giri, Andrew J. Page, Shruti K. Rereddy, Bhagirath Majmudar, and Susan Muller. "Abstract A89: Racial disparity in p16 positive oropharyngeal squamous cell carcinoma." In Abstracts: Sixth AACR Conference: The Science of Cancer Health Disparities; December 6–9, 2013; Atlanta, GA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7755.disp13-a89.

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Chae, Jeesoo, Weon Seo Park, Dongwan Hong, Jong-Il Kim, and Yuh-Seog Jung. "Abstract 4371: Genomic characterization of oropharyngeal squamous cell carcinoma in Korean population." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4371.

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Ren, Shuling, Daria A. Gaykalova, Theresa Guo, Zubair Khan, Mizuo Ando, Sunny Haft, and Joseph A. Califano. "Abstract 3353: An epigenetic biomarker panel in HPV related oropharyngeal squamous cell carcinoma." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3353.

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Won, Hye Sung, Ji Hyung Hong, Eun Kyoung Jeon, Yoon Ho Ko, Sang Hoon Chun, Chan-Kwon Jung, and Jin-Hyoung Kang. "Abstract B21: The difference in the role of PI3K/Akt/mTOR pathway between oropharyngeal squamous cell carcinoma and oral cavity squamous cell carcinoma." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-b21.

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Reder, H., S. Wagner, U. Gamerdinger, S. Sandmann, N. Würdemann, A. Bräuninger, M. Dugas, S. Gattenlöhner, JP Klußmann, and C. Wittekindt. "Genetic Alterations in HPV-associated Oropharyngeal Squamous Cell Carcinoma of Patients with Treatment Failure." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686057.

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Weiss, BG, Mahalia Zoe Anczykowski, M. Canis, F. Ihler, J. Kitz, and M. Jakob. "Prognostic impact of additional HPV-typing in p16-stratified advanced oropharyngeal squamous cell carcinoma." In Abstract- und Posterband – 91. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Welche Qualität macht den Unterschied. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1711038.

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Hiles, Guadalupe Lorenzatti, Chun-I. Wang, Lisa M. Pinatti, Christine M. Goudsmit, Lila Peters, Hannah L. Briggs, Trey B. Thomas, et al. "Abstract B07: High-risk human papillomavirus association with oropharyngeal squamous cell carcinoma in Taiwan." In Abstracts: AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 29-30, 2019; Austin, TX. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3265.aacrahns19-b07.

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Reports on the topic "Oropharyngeal squamous cell carcinoma"

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Drucker, Aaron, Gaelen P. Adam, Valerie Langberg, Abhilash Gazula, Bryant Smith, Farah Moustafa, Martin A. Weinstock, and Thomas A. Trikalinos. Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin. Agency for Healthcare Research and Quality, 2017. http://dx.doi.org/10.23970/ahrqepccer199.

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Heaton, D., R. Mustafi, and J. L. Schwartz. 9-{beta}-arabinofuranosyladenine preferentially sensitizes radioresistant squamous cell carcinoma cell lines to x-rays. Office of Scientific and Technical Information (OSTI), June 1992. http://dx.doi.org/10.2172/10149645.

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Poindexter, Samuel E. Comparing Immunohistologic and Demographic Variables of Head and Neck Squamous Cell Carcinoma. Fort Belvoir, VA: Defense Technical Information Center, May 2015. http://dx.doi.org/10.21236/ad1012738.

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Tasso, Camilla Olga, Analú Barros de Oliveira, Túlio Morandin Ferrisse, and Janaina Habib Jorge Jorge. Association between Candida Albicans and Squamous Cell Carcinoma: A Systematic Literature Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2021. http://dx.doi.org/10.37766/inplasy2021.3.0005.

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Wang, Dong, XiaoJie Duan, Yuhui Zhang, Zhen Meng, and Jing Wang. Traditional Chinese medicine for oral squamous cell carcinoma: A Bayesian network meta-analysis protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2020. http://dx.doi.org/10.37766/inplasy2020.9.0082.

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Wang, Mingfei, Linfeng Zhang, Wenhao Ren, Shaoming Li, Keqian Zhi, Jingjing Zheng, and Ling Gao. Diagnostic Value of CircRNAs as Potential Biomarker in Oral Squamous Cell Carcinoma: A Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0037.

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Kloss-Brandstatter, A., G. Erhart, H. Weissensteiner, G. Schafer, L. Forer, S. Schonherr, D. Pacher, et al. Somatic mitochondrial DNA mutations are associated with progression, metastasis and death in oral squamous cell carcinoma. Cold Spring Harbor Laboratory, January 2014. http://dx.doi.org/10.1101/002055.

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Liang, Feixin. Effect of reactive oxygen species on the ligand-independent activation of EGFR in tongue squamous cell carcinoma. Science Repository, June 2018. http://dx.doi.org/10.31487/j.dobcr.2018.02.005.

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Iacobone, Anna Daniela. The impact of HPV infection on risk of progression and overall mortality in vulvar squamous cell carcinoma: a retrospective single-center analysis. Science Repository OÜ, February 2019. http://dx.doi.org/10.31487/j.jso.2019.01.003.

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Zhan, Ze-Jiang, Fang Zhang, Wen-Ze Qiu, Tai-Ze Yuan, and Rong-Hui Zheng. The optimal second-line treatment model for recurrent and/or metastatic head and neck squamous cell carcinoma: a Bayesian network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2020. http://dx.doi.org/10.37766/inplasy2020.11.0041.

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